GREMLIN Database
Q97VX0 - DNA endonuclease III (NtH-2)
UniProt: Q97VX0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (200)
Sequences: 8288 (5252)
Seq/√Len: 371.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_N124_L3.8531.00
74_D77_K3.4821.00
209_K212_D3.2991.00
109_I113_L3.1281.00
120_Y146_K2.7791.00
204_F209_K2.7681.00
109_I129_D2.6351.00
70_K85_E2.6191.00
86_L104_I2.4921.00
87_Y97_K2.4671.00
104_I108_K2.3081.00
27_V187_E2.2911.00
122_R126_L2.2871.00
171_N175_R2.2681.00
70_K89_V2.2621.00
114_G127_S2.2181.00
88_D91_K2.1881.00
41_S44_E2.0811.00
76_Y111_I2.0051.00
50_I106_L2.0021.00
108_K112_N1.9591.00
102_R105_N1.9571.00
73_T77_K1.9521.00
216_K222_Y1.9121.00
83_E87_Y1.8871.00
82_T85_E1.8761.00
83_E104_I1.8231.00
47_I103_L1.8141.00
105_N129_D1.8021.00
76_Y80_N1.7721.00
113_L127_S1.7471.00
32_S37_D1.7061.00
43_E75_F1.7001.00
27_V190_L1.7001.00
72_L81_T1.6741.00
156_K173_V1.6411.00
65_E69_S1.6011.00
124_L127_S1.5611.00
111_I116_V1.5581.00
122_R148_N1.5381.00
165_I176_L1.5161.00
55_S59_I1.5151.00
43_E107_S1.5151.00
66_E69_S1.5091.00
40_K44_E1.5091.00
122_R140_L1.4411.00
44_E68_R1.4361.00
105_N108_K1.4161.00
66_E89_V1.4041.00
25_W217_K1.3991.00
21_K218_V1.3801.00
164_G220_K1.3741.00
162_V215_L1.3721.00
181_L191_L1.3621.00
72_L89_V1.3531.00
187_E190_L1.3431.00
140_L146_K1.3341.00
117_E120_Y1.3341.00
120_Y144_G1.3251.00
197_T201_A1.3201.00
55_S93_I1.3151.00
81_T86_L1.3151.00
109_I127_S1.2601.00
126_L133_E1.2491.00
59_I62_S1.2421.00
162_V218_V1.2251.00
87_Y96_Y1.2001.00
109_I114_G1.1851.00
46_I50_I1.1631.00
83_E101_K1.1631.00
106_L128_I1.1621.00
184_N187_E1.1601.00
42_A143_A1.1571.00
84_Q87_Y1.1561.00
52_V57_W1.1531.00
62_S65_E1.1531.00
110_I118_K1.1531.00
190_L194_G1.1441.00
26_I30_E1.1341.00
171_N174_K1.1331.00
23_K27_V1.1311.00
145_H189_K1.1301.00
114_G124_L1.1281.00
113_L124_L1.1231.00
105_N109_I1.1191.00
202_F214_I1.1151.00
82_T104_I1.1061.00
47_I68_R1.1011.00
125_L140_L1.0891.00
215_L218_V1.0701.00
203_C210_C1.0651.00
64_V68_R1.0641.00
174_K178_E1.0551.00
78_L86_L1.0541.00
56_R59_I1.0541.00
46_I139_I1.0451.00
44_E64_V1.0401.00
133_E174_K1.0381.00
83_E100_V1.0371.00
159_L177_V1.0291.00
169_K172_E1.0161.00
24_G28_S1.0151.00
36_W201_A1.0121.00
21_K24_G1.0051.00
43_E78_L0.9861.00
198_V202_F0.9711.00
173_V177_V0.9681.00
140_L148_N0.9681.00
78_L107_S0.9591.00
83_E108_K0.9511.00
58_E62_S0.9481.00
101_K105_N0.9451.00
167_I173_V0.9331.00
106_L109_I0.9271.00
198_V214_I0.9221.00
106_L110_I0.9211.00
61_K65_E0.9211.00
85_E89_V0.9171.00
49_A139_I0.9131.00
170_K173_V0.9111.00
46_I106_L0.9061.00
141_L150_P0.9001.00
203_C213_C0.8931.00
38_G41_S0.8901.00
25_W29_S0.8861.00
159_L195_I0.8861.00
191_L195_I0.8841.00
79_C107_S0.8801.00
30_E197_T0.8771.00
38_G65_E0.8751.00
53_Q135_T0.8751.00
167_I172_E0.8721.00
44_E73_T0.8721.00
75_F111_I0.8721.00
123_N126_L0.8691.00
141_L192_H0.8661.00
29_S214_I0.8581.00
21_K25_W0.8551.00
47_I106_L0.8541.00
150_P192_H0.8411.00
202_F212_D0.8401.00
175_R178_E0.8311.00
66_E92_G0.8291.00
122_R146_K0.8211.00
149_F188_Y0.8161.00
172_E176_L0.8131.00
79_C111_I0.8131.00
81_T85_E0.8091.00
59_I92_G0.8071.00
122_R137_D0.8071.00
141_L189_K0.8071.00
72_L85_E0.8031.00
140_L144_G0.8011.00
63_K66_E0.8001.00
20_L24_G0.7991.00
176_L180_N0.7981.00
22_E215_L0.7931.00
76_Y116_V0.7911.00
97_K102_R0.7891.00
210_C219_C0.7891.00
167_I176_L0.7881.00
122_R136_A0.7861.00
160_S173_V0.7811.00
131_I135_T0.7771.00
25_W214_I0.7751.00
149_F182_E0.7751.00
23_K190_L0.7631.00
156_K160_S0.7631.00
62_S66_E0.7621.00
85_E88_D0.7541.00
66_E70_K0.7481.00
75_F118_K0.7471.00
170_K174_K0.7461.00
137_D149_F0.7431.00
160_S165_I0.7431.00
26_I193_A0.7321.00
142_F189_K0.7311.00
103_L107_S0.7311.00
116_V119_F0.7281.00
169_K173_V0.7231.00
118_K125_L0.7221.00
45_I143_A0.7221.00
21_K217_K0.7181.00
210_C213_C0.7121.00
49_A142_F0.7100.99
33_Y57_W0.7070.99
183_R188_Y0.7070.99
49_A135_T0.7060.99
178_E182_E0.7020.99
184_N188_Y0.7000.99
111_I114_G0.6990.99
79_C104_I0.6980.99
110_I116_V0.6940.99
59_I93_I0.6900.99
100_V104_I0.6860.99
51_L60_V0.6820.99
161_R203_C0.6820.99
100_V103_L0.6760.99
24_G27_V0.6730.99
158_V198_V0.6710.99
139_I143_A0.6650.99
79_C108_K0.6650.99
33_Y36_W0.6630.99
25_W28_S0.6620.99
72_L86_L0.6610.99
133_E137_D0.6610.99
58_E61_K0.6590.99
75_F107_S0.6560.99
79_C82_T0.6550.99
51_L93_I0.6530.99
203_C219_C0.6520.99
141_L148_N0.6510.99
198_V201_A0.6510.99
218_V222_Y0.6510.99
176_L179_E0.6490.99
89_V92_G0.6470.99
81_T104_I0.6400.99
26_I36_W0.6360.99
155_G195_I0.6340.99
137_D174_K0.6320.99
161_R208_P0.6300.99
22_E194_G0.6300.99
126_L136_A0.6290.99
47_I50_I0.6290.99
60_V93_I0.6280.99
175_R179_E0.6230.99
131_I139_I0.6180.99
147_P184_N0.6170.99
147_P183_R0.6130.99
73_T78_L0.6110.98
135_T139_I0.6080.98
50_I103_L0.6070.98
122_R133_E0.6050.98
163_L180_N0.6050.98
148_N188_Y0.6020.98
125_L139_I0.6020.98
149_F191_L0.6000.98
86_L90_L0.5980.98
177_V181_L0.5970.98
131_I136_A0.5970.98
121_N140_L0.5960.98
142_F193_A0.5950.98
109_I128_I0.5950.98
133_E178_E0.5930.98
125_L131_I0.5930.98
33_Y197_T0.5930.98
174_K177_V0.5920.98
44_E78_L0.5890.98
108_K111_I0.5860.98
187_E194_G0.5850.98
204_F207_N0.5830.98
77_K80_N0.5780.98
120_Y124_L0.5740.98
46_I110_I0.5710.98
137_D150_P0.5700.98
151_P156_K0.5680.98
62_S92_G0.5680.98
127_S140_L0.5630.97
178_E188_Y0.5610.97
41_S73_T0.5610.97
48_S64_V0.5600.97
147_P189_K0.5590.97
156_K169_K0.5570.97
38_G45_I0.5550.97
63_K93_I0.5530.97
35_W142_F0.5510.97
160_S167_I0.5500.97
172_E175_R0.5500.97
149_F178_E0.5500.97
87_Y100_V0.5490.97
38_G44_E0.5450.97
213_C219_C0.5430.97
211_E216_K0.5400.97
22_E26_I0.5370.97
42_A144_G0.5360.97
137_D178_E0.5350.97
188_Y192_H0.5340.96
26_I31_T0.5320.96
149_F177_V0.5320.96
23_K187_E0.5290.96
31_T36_W0.5230.96
161_R204_F0.5200.96
51_L67_M0.5190.96
41_S45_I0.5190.96
134_E151_P0.5130.96
151_P155_G0.5110.96
101_K129_D0.5110.96
134_E154_Y0.5100.95
137_D148_N0.5090.95
162_V220_K0.5090.95
153_E205_I0.5090.95
55_S94_N0.5070.95
80_N111_I0.5070.95
117_E144_G0.5050.95
63_K92_G0.5050.95
50_I131_I0.5040.95
148_N182_E0.5030.95
118_K144_G0.5010.95
149_F192_H0.5010.95
46_I118_K0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fspA 1 0.9251 100 0.216 Contact Map
3n5nX 1 0.9559 100 0.227 Contact Map
1kg2A 1 0.9251 100 0.228 Contact Map
1ornA 1 0.9339 100 0.241 Contact Map
1keaA 2 0.9383 100 0.244 Contact Map
4unfA 1 0.9736 100 0.245 Contact Map
2abkA 1 0.9251 100 0.249 Contact Map
4uobA 1 0.9692 100 0.258 Contact Map
1pu6A 1 0.8502 100 0.363 Contact Map
3n0uA 1 0.8546 100 0.48 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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