Q97VX0 - SULSO - GREMLIN Contacts

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Q97VX0 - DNA endonuclease III (NtH-2)

UniProt:	Q97VX0	Sequences: MVRKILDTLLKIFENNKSILKEKGWIVSSETSYEWWDGLKSAEEIIISAILVQMSRWEIVKSKVEEMRSKGLTDFYKLCNTTEQELYDVLKGINFYKTKVKRLINLSKIIINLGSVEKFYNRNLLLSIDGIGEETADSILLFAGHKPNFPPSEYGKRVLSRVLGISIKKKNEVKRLVEENLERNVYEYKLLHAGIVTVGRAFCFIENPKCEDCILKKVCKYYRENSS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	227 (200)
Sequences:	8288 (5252)
Seq/√Len:	371.3

ECOLI - END3 MUTY
BACSU - END3 YFHQ
HALSA - Q9HRQ5 Q9HPQ6 Q9HS56
SULSO - Q97VX0 Q7LXY0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
121_N	124_L	3.853	1.00
74_D	77_K	3.482	1.00
209_K	212_D	3.299	1.00
109_I	113_L	3.128	1.00
120_Y	146_K	2.779	1.00
204_F	209_K	2.768	1.00
109_I	129_D	2.635	1.00
70_K	85_E	2.619	1.00
86_L	104_I	2.492	1.00
87_Y	97_K	2.467	1.00
104_I	108_K	2.308	1.00
27_V	187_E	2.291	1.00
122_R	126_L	2.287	1.00
171_N	175_R	2.268	1.00
70_K	89_V	2.262	1.00
114_G	127_S	2.218	1.00
88_D	91_K	2.188	1.00
41_S	44_E	2.081	1.00
76_Y	111_I	2.005	1.00
50_I	106_L	2.002	1.00
108_K	112_N	1.959	1.00
102_R	105_N	1.957	1.00
73_T	77_K	1.952	1.00
216_K	222_Y	1.912	1.00
83_E	87_Y	1.887	1.00
82_T	85_E	1.876	1.00
83_E	104_I	1.823	1.00
47_I	103_L	1.814	1.00
105_N	129_D	1.802	1.00
76_Y	80_N	1.772	1.00
113_L	127_S	1.747	1.00
32_S	37_D	1.706	1.00
43_E	75_F	1.700	1.00
27_V	190_L	1.700	1.00
72_L	81_T	1.674	1.00
156_K	173_V	1.641	1.00
65_E	69_S	1.601	1.00
124_L	127_S	1.561	1.00
111_I	116_V	1.558	1.00
122_R	148_N	1.538	1.00
165_I	176_L	1.516	1.00
55_S	59_I	1.515	1.00
43_E	107_S	1.515	1.00
66_E	69_S	1.509	1.00
40_K	44_E	1.509	1.00
122_R	140_L	1.441	1.00
44_E	68_R	1.436	1.00
105_N	108_K	1.416	1.00
66_E	89_V	1.404	1.00
25_W	217_K	1.399	1.00
21_K	218_V	1.380	1.00
164_G	220_K	1.374	1.00
162_V	215_L	1.372	1.00
181_L	191_L	1.362	1.00
72_L	89_V	1.353	1.00
187_E	190_L	1.343	1.00
140_L	146_K	1.334	1.00
117_E	120_Y	1.334	1.00
120_Y	144_G	1.325	1.00
197_T	201_A	1.320	1.00
55_S	93_I	1.315	1.00
81_T	86_L	1.315	1.00
109_I	127_S	1.260	1.00
126_L	133_E	1.249	1.00
59_I	62_S	1.242	1.00
162_V	218_V	1.225	1.00
87_Y	96_Y	1.200	1.00
109_I	114_G	1.185	1.00
46_I	50_I	1.163	1.00
83_E	101_K	1.163	1.00
106_L	128_I	1.162	1.00
184_N	187_E	1.160	1.00
42_A	143_A	1.157	1.00
84_Q	87_Y	1.156	1.00
52_V	57_W	1.153	1.00
62_S	65_E	1.153	1.00
110_I	118_K	1.153	1.00
190_L	194_G	1.144	1.00
26_I	30_E	1.134	1.00
171_N	174_K	1.133	1.00
23_K	27_V	1.131	1.00
145_H	189_K	1.130	1.00
114_G	124_L	1.128	1.00
113_L	124_L	1.123	1.00
105_N	109_I	1.119	1.00
202_F	214_I	1.115	1.00
82_T	104_I	1.106	1.00
47_I	68_R	1.101	1.00
125_L	140_L	1.089	1.00
215_L	218_V	1.070	1.00
203_C	210_C	1.065	1.00
64_V	68_R	1.064	1.00
174_K	178_E	1.055	1.00
78_L	86_L	1.054	1.00
56_R	59_I	1.054	1.00
46_I	139_I	1.045	1.00
44_E	64_V	1.040	1.00
133_E	174_K	1.038	1.00
83_E	100_V	1.037	1.00
159_L	177_V	1.029	1.00
169_K	172_E	1.016	1.00
24_G	28_S	1.015	1.00
36_W	201_A	1.012	1.00
21_K	24_G	1.005	1.00
43_E	78_L	0.986	1.00
198_V	202_F	0.971	1.00
173_V	177_V	0.968	1.00
140_L	148_N	0.968	1.00
78_L	107_S	0.959	1.00
83_E	108_K	0.951	1.00
58_E	62_S	0.948	1.00
101_K	105_N	0.945	1.00
167_I	173_V	0.933	1.00
106_L	109_I	0.927	1.00
198_V	214_I	0.922	1.00
106_L	110_I	0.921	1.00
61_K	65_E	0.921	1.00
85_E	89_V	0.917	1.00
49_A	139_I	0.913	1.00
170_K	173_V	0.911	1.00
46_I	106_L	0.906	1.00
141_L	150_P	0.900	1.00
203_C	213_C	0.893	1.00
38_G	41_S	0.890	1.00
25_W	29_S	0.886	1.00
159_L	195_I	0.886	1.00
191_L	195_I	0.884	1.00
79_C	107_S	0.880	1.00
30_E	197_T	0.877	1.00
38_G	65_E	0.875	1.00
53_Q	135_T	0.875	1.00
167_I	172_E	0.872	1.00
44_E	73_T	0.872	1.00
75_F	111_I	0.872	1.00
123_N	126_L	0.869	1.00
141_L	192_H	0.866	1.00
29_S	214_I	0.858	1.00
21_K	25_W	0.855	1.00
47_I	106_L	0.854	1.00
150_P	192_H	0.841	1.00
202_F	212_D	0.840	1.00
175_R	178_E	0.831	1.00
66_E	92_G	0.829	1.00
122_R	146_K	0.821	1.00
149_F	188_Y	0.816	1.00
172_E	176_L	0.813	1.00
79_C	111_I	0.813	1.00
81_T	85_E	0.809	1.00
59_I	92_G	0.807	1.00
122_R	137_D	0.807	1.00
141_L	189_K	0.807	1.00
72_L	85_E	0.803	1.00
140_L	144_G	0.801	1.00
63_K	66_E	0.800	1.00
20_L	24_G	0.799	1.00
176_L	180_N	0.798	1.00
22_E	215_L	0.793	1.00
76_Y	116_V	0.791	1.00
97_K	102_R	0.789	1.00
210_C	219_C	0.789	1.00
167_I	176_L	0.788	1.00
122_R	136_A	0.786	1.00
160_S	173_V	0.781	1.00
131_I	135_T	0.777	1.00
25_W	214_I	0.775	1.00
149_F	182_E	0.775	1.00
23_K	190_L	0.763	1.00
156_K	160_S	0.763	1.00
62_S	66_E	0.762	1.00
85_E	88_D	0.754	1.00
66_E	70_K	0.748	1.00
75_F	118_K	0.747	1.00
170_K	174_K	0.746	1.00
137_D	149_F	0.743	1.00
160_S	165_I	0.743	1.00
26_I	193_A	0.732	1.00
142_F	189_K	0.731	1.00
103_L	107_S	0.731	1.00
116_V	119_F	0.728	1.00
169_K	173_V	0.723	1.00
118_K	125_L	0.722	1.00
45_I	143_A	0.722	1.00
21_K	217_K	0.718	1.00
210_C	213_C	0.712	1.00
49_A	142_F	0.710	0.99
33_Y	57_W	0.707	0.99
183_R	188_Y	0.707	0.99
49_A	135_T	0.706	0.99
178_E	182_E	0.702	0.99
184_N	188_Y	0.700	0.99
111_I	114_G	0.699	0.99
79_C	104_I	0.698	0.99
110_I	116_V	0.694	0.99
59_I	93_I	0.690	0.99
100_V	104_I	0.686	0.99
51_L	60_V	0.682	0.99
161_R	203_C	0.682	0.99
100_V	103_L	0.676	0.99
24_G	27_V	0.673	0.99
158_V	198_V	0.671	0.99
139_I	143_A	0.665	0.99
79_C	108_K	0.665	0.99
33_Y	36_W	0.663	0.99
25_W	28_S	0.662	0.99
72_L	86_L	0.661	0.99
133_E	137_D	0.661	0.99
58_E	61_K	0.659	0.99
75_F	107_S	0.656	0.99
79_C	82_T	0.655	0.99
51_L	93_I	0.653	0.99
203_C	219_C	0.652	0.99
141_L	148_N	0.651	0.99
198_V	201_A	0.651	0.99
218_V	222_Y	0.651	0.99
176_L	179_E	0.649	0.99
89_V	92_G	0.647	0.99
81_T	104_I	0.640	0.99
26_I	36_W	0.636	0.99
155_G	195_I	0.634	0.99
137_D	174_K	0.632	0.99
161_R	208_P	0.630	0.99
22_E	194_G	0.630	0.99
126_L	136_A	0.629	0.99
47_I	50_I	0.629	0.99
60_V	93_I	0.628	0.99
175_R	179_E	0.623	0.99
131_I	139_I	0.618	0.99
147_P	184_N	0.617	0.99
147_P	183_R	0.613	0.99
73_T	78_L	0.611	0.98
135_T	139_I	0.608	0.98
50_I	103_L	0.607	0.98
122_R	133_E	0.605	0.98
163_L	180_N	0.605	0.98
148_N	188_Y	0.602	0.98
125_L	139_I	0.602	0.98
149_F	191_L	0.600	0.98
86_L	90_L	0.598	0.98
177_V	181_L	0.597	0.98
131_I	136_A	0.597	0.98
121_N	140_L	0.596	0.98
142_F	193_A	0.595	0.98
109_I	128_I	0.595	0.98
133_E	178_E	0.593	0.98
125_L	131_I	0.593	0.98
33_Y	197_T	0.593	0.98
174_K	177_V	0.592	0.98
44_E	78_L	0.589	0.98
108_K	111_I	0.586	0.98
187_E	194_G	0.585	0.98
204_F	207_N	0.583	0.98
77_K	80_N	0.578	0.98
120_Y	124_L	0.574	0.98
46_I	110_I	0.571	0.98
137_D	150_P	0.570	0.98
151_P	156_K	0.568	0.98
62_S	92_G	0.568	0.98
127_S	140_L	0.563	0.97
178_E	188_Y	0.561	0.97
41_S	73_T	0.561	0.97
48_S	64_V	0.560	0.97
147_P	189_K	0.559	0.97
156_K	169_K	0.557	0.97
38_G	45_I	0.555	0.97
63_K	93_I	0.553	0.97
35_W	142_F	0.551	0.97
160_S	167_I	0.550	0.97
172_E	175_R	0.550	0.97
149_F	178_E	0.550	0.97
87_Y	100_V	0.549	0.97
38_G	44_E	0.545	0.97
213_C	219_C	0.543	0.97
211_E	216_K	0.540	0.97
22_E	26_I	0.537	0.97
42_A	144_G	0.536	0.97
137_D	178_E	0.535	0.97
188_Y	192_H	0.534	0.96
26_I	31_T	0.532	0.96
149_F	177_V	0.532	0.96
23_K	187_E	0.529	0.96
31_T	36_W	0.523	0.96
161_R	204_F	0.520	0.96
51_L	67_M	0.519	0.96
41_S	45_I	0.519	0.96
134_E	151_P	0.513	0.96
151_P	155_G	0.511	0.96
101_K	129_D	0.511	0.96
134_E	154_Y	0.510	0.95
137_D	148_N	0.509	0.95
162_V	220_K	0.509	0.95
153_E	205_I	0.509	0.95
55_S	94_N	0.507	0.95
80_N	111_I	0.507	0.95
117_E	144_G	0.505	0.95
63_K	92_G	0.505	0.95
50_I	131_I	0.504	0.95
148_N	182_E	0.503	0.95
118_K	144_G	0.501	0.95
149_F	192_H	0.501	0.95
46_I	118_K	0.500	0.95

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fspA	1	0.9251	100	0.216	Contact Map
3n5nX	1	0.9559	100	0.227	Contact Map
1kg2A	1	0.9251	100	0.228	Contact Map
1ornA	1	0.9339	100	0.241	Contact Map
1keaA	2	0.9383	100	0.244	Contact Map
4unfA	1	0.9736	100	0.245	Contact Map
2abkA	1	0.9251	100	0.249	Contact Map
4uobA	1	0.9692	100	0.258	Contact Map
1pu6A	1	0.8502	100	0.363	Contact Map
3n0uA	1	0.8546	100	0.48	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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