GREMLIN Database
Q97VW9 - Uncharacterized protein
UniProt: Q97VW9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (301)
Sequences: 4287 (3081)
Seq/√Len: 177.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
260_A263_L3.6961.00
270_A277_F3.0841.00
267_K271_E3.0071.00
23_Y27_K2.8051.00
23_Y26_E2.7841.00
219_D222_K2.7481.00
15_G216_F2.7441.00
180_R280_D2.7171.00
230_V242_V2.6191.00
263_L279_S2.6131.00
300_P303_F2.5741.00
86_I101_Q2.5641.00
30_F81_K2.5471.00
78_A103_L2.5041.00
279_S282_I2.4271.00
22_Q48_N2.4171.00
289_V293_A2.4061.00
41_Q45_Q2.3111.00
109_Y135_F2.2511.00
135_F152_V2.1991.00
254_N257_W2.1701.00
267_K270_A2.0961.00
95_I123_A2.0091.00
98_S108_V1.9611.00
169_I231_I1.9551.00
58_E61_E1.9211.00
45_Q218_P1.9071.00
293_A296_N1.9001.00
32_I97_P1.8971.00
276_T293_A1.8871.00
133_G150_I1.8791.00
136_L151_V1.8571.00
168_Y193_R1.8471.00
197_Q217_D1.8241.00
300_P304_D1.8171.00
263_L267_K1.8021.00
303_F307_T1.7961.00
41_Q200_K1.7921.00
78_A104_K1.7821.00
304_D307_T1.7681.00
305_T309_N1.7631.00
300_P307_T1.7571.00
4_I32_I1.7271.00
113_S154_P1.7171.00
20_I87_I1.7161.00
36_D40_R1.6891.00
301_N304_D1.6861.00
269_Y275_A1.6841.00
102_F130_Y1.6661.00
55_K58_E1.6621.00
57_R60_D1.6591.00
74_I100_F1.6531.00
22_Q25_P1.6441.00
307_T310_L1.5951.00
306_G310_L1.5761.00
28_V49_K1.5561.00
108_V131_A1.5421.00
179_K202_D1.5251.00
285_S290_L1.5151.00
230_V247_K1.5151.00
120_K144_L1.5071.00
181_L252_V1.5041.00
40_R44_S1.4871.00
239_M251_M1.4871.00
166_E193_R1.4801.00
304_D308_P1.4631.00
306_G309_N1.4621.00
102_F105_G1.4571.00
14_T38_Y1.4551.00
4_I83_Y1.4541.00
200_K215_S1.4361.00
162_E193_R1.4111.00
169_I194_I1.3831.00
288_N292_E1.3821.00
50_I53_I1.3811.00
71_F75_V1.3791.00
122_K258_K1.3701.00
11_G15_G1.3641.00
242_V249_V1.3631.00
234_Q251_M1.3631.00
64_L67_F1.3581.00
20_I89_T1.3441.00
168_Y195_V1.3421.00
303_F306_G1.3401.00
301_N305_T1.3361.00
242_V251_M1.3301.00
302_V306_G1.3211.00
232_T238_A1.3181.00
298_N303_F1.2991.00
287_Y291_L1.2931.00
99_F103_L1.2911.00
5_L17_A1.2811.00
195_V226_N1.2751.00
184_A288_N1.2731.00
56_G60_D1.2671.00
136_L141_Q1.2611.00
183_D186_V1.2601.00
56_G59_P1.2561.00
22_Q46_Y1.2421.00
195_V214_F1.2321.00
296_N303_F1.2231.00
264_S267_K1.2231.00
276_T303_F1.2191.00
137_H154_P1.2161.00
72_S76_K1.2001.00
282_I289_V1.1771.00
293_A297_A1.1751.00
308_P311_V1.1741.00
85_L109_Y1.1731.00
157_E226_N1.1691.00
184_A291_L1.1671.00
269_Y274_G1.1641.00
3_R85_L1.1611.00
62_S65_V1.1521.00
140_E271_E1.1451.00
260_A279_S1.1451.00
30_F51_Y1.1441.00
55_K60_D1.1421.00
4_I81_K1.1401.00
276_T296_N1.1341.00
195_V223_W1.1321.00
65_V69_R1.1321.00
156_V244_M1.1311.00
5_L21_A1.1221.00
172_T238_A1.1151.00
251_M275_A1.1151.00
33_P39_S1.1141.00
198_T206_Y1.1091.00
167_G298_N1.1091.00
98_S127_I1.1051.00
157_E162_E1.0961.00
270_A276_T1.0951.00
94_S123_A1.0901.00
163_S193_R1.0851.00
139_Q151_V1.0831.00
197_Q216_F1.0811.00
287_Y290_L1.0771.00
195_V212_T1.0761.00
137_H240_E1.0761.00
170_L223_W1.0711.00
258_K261_T1.0711.00
51_Y76_K1.0701.00
57_R61_E1.0671.00
163_S166_E1.0651.00
302_V305_T1.0631.00
250_I276_T1.0611.00
34_T40_R1.0601.00
263_L277_F1.0591.00
203_P215_S1.0591.00
67_F71_F1.0521.00
298_N304_D1.0501.00
249_V275_A1.0461.00
217_D223_W1.0431.00
142_R149_G1.0330.99
74_I99_F1.0320.99
3_R24_L1.0300.99
297_A300_P1.0290.99
7_I89_T1.0270.99
243_V269_Y1.0260.99
168_Y226_N1.0230.99
276_T279_S1.0220.99
66_L70_L1.0200.99
292_E296_N1.0160.99
157_E161_Y1.0120.99
75_V78_A1.0100.99
100_F104_K1.0100.99
56_G61_E1.0070.99
238_A242_V1.0020.99
75_V103_L1.0000.99
123_A127_I0.9990.99
202_D205_I0.9990.99
54_P76_K0.9980.99
182_F188_S0.9950.99
278_L289_V0.9930.99
273_L310_L0.9920.99
60_D63_S0.9900.99
136_L142_R0.9880.99
304_D310_L0.9850.99
255_N280_D0.9800.99
139_Q142_R0.9760.99
172_T220_L0.9650.99
299_E302_V0.9620.99
193_R212_T0.9600.99
307_T311_V0.9520.99
164_K193_R0.9470.99
31_V48_N0.9450.99
196_I211_V0.9430.99
50_I54_P0.9400.99
99_F130_Y0.9370.99
32_I80_I0.9310.99
201_I215_S0.9300.99
252_V278_L0.9290.99
119_T264_S0.9260.99
184_A188_S0.9240.99
299_E310_L0.9220.99
44_S47_A0.9210.99
166_E210_N0.9210.99
267_K277_F0.9210.99
107_K132_K0.9160.99
37_P40_R0.9150.99
120_K141_Q0.9130.99
75_V79_S0.9090.99
14_T42_M0.9040.99
128_S134_V0.9040.99
221_E224_I0.9030.99
17_A89_T0.8980.99
140_E268_K0.8960.99
162_E168_Y0.8940.99
289_V292_E0.8940.99
300_P310_L0.8820.98
102_F131_A0.8810.98
296_N300_P0.8790.98
103_L130_Y0.8750.98
102_F108_V0.8750.98
154_P237_T0.8730.98
21_A48_N0.8730.98
254_N280_D0.8720.98
300_P306_G0.8720.98
198_T213_T0.8670.98
88_A98_S0.8660.98
240_E243_V0.8660.98
159_P219_D0.8650.98
110_G131_A0.8620.98
301_N308_P0.8610.98
137_H141_Q0.8600.98
229_L304_D0.8600.98
300_P308_P0.8510.98
136_L149_G0.8500.98
15_G42_M0.8480.98
182_F186_V0.8470.98
229_L250_I0.8460.98
278_L285_S0.8450.98
184_A187_K0.8410.98
30_F49_K0.8390.98
120_K145_Y0.8360.98
178_F254_N0.8310.98
29_D48_N0.8310.98
286_D289_V0.8280.98
34_T37_P0.8240.97
303_F310_L0.8220.97
231_I252_V0.8140.97
16_F155_I0.8120.97
89_T111_I0.8070.97
137_H151_V0.8070.97
167_G301_N0.8060.97
180_R255_N0.8050.97
239_M269_Y0.8000.97
69_R72_S0.7950.97
178_F233_H0.7910.97
159_P222_K0.7900.97
53_I73_I0.7890.97
89_T113_S0.7870.97
3_R87_I0.7840.97
72_S78_A0.7830.97
35_N40_R0.7820.97
7_I31_V0.7810.97
54_P58_E0.7800.97
7_I93_H0.7730.96
179_K280_D0.7720.96
208_N211_V0.7720.96
186_V190_I0.7690.96
285_S289_V0.7670.96
55_K61_E0.7670.96
5_L87_I0.7660.96
232_T251_M0.7650.96
136_L152_V0.7650.96
257_W261_T0.7640.96
108_V132_K0.7600.96
185_I188_S0.7580.96
229_L294_I0.7580.96
291_L295_E0.7490.96
25_P29_D0.7450.95
257_W260_A0.7440.95
220_L224_I0.7380.95
51_Y81_K0.7370.95
178_F255_N0.7370.95
193_R210_N0.7360.95
139_Q268_K0.7330.95
156_V245_Y0.7320.95
113_S124_I0.7270.95
187_K190_I0.7250.95
186_V189_V0.7250.95
298_N306_G0.7250.95
5_L24_L0.7250.95
157_E168_Y0.7210.95
297_A304_D0.7150.94
298_N301_N0.7110.94
254_N258_K0.7100.94
252_V280_D0.7090.94
290_L297_A0.7080.94
59_P64_L0.7010.94
74_I103_L0.7000.94
41_Q218_P0.6980.94
137_H237_T0.6970.94
203_P213_T0.6950.93
38_Y42_M0.6950.93
139_Q272_I0.6920.93
246_R311_V0.6920.93
299_E306_G0.6900.93
24_L29_D0.6900.93
296_N299_E0.6880.93
172_T197_Q0.6880.93
133_G148_K0.6870.93
145_Y149_G0.6870.93
305_T308_P0.6850.93
4_I30_F0.6850.93
55_K59_P0.6820.93
170_L247_K0.6810.93
6_I31_V0.6800.93
53_I58_E0.6780.93
157_E160_K0.6760.93
28_V81_K0.6750.92
63_S66_L0.6740.92
70_L73_I0.6720.92
301_N307_T0.6680.92
35_N54_P0.6670.92
298_N307_T0.6660.92
304_D311_V0.6610.92
303_F308_P0.6600.92
246_R308_P0.6580.91
163_S168_Y0.6570.91
76_K79_S0.6540.91
158_K161_Y0.6530.91
202_D256_D0.6520.91
112_E121_G0.6510.91
68_K72_S0.6510.91
29_D33_P0.6490.91
180_R285_S0.6450.91
124_I145_Y0.6430.91
4_I80_I0.6430.91
43_I46_Y0.6390.90
53_I60_D0.6360.90
297_A307_T0.6360.90
173_T178_F0.6350.90
33_P36_D0.6350.90
300_P311_V0.6350.90
108_V127_I0.6340.90
5_L89_T0.6330.90
110_G134_V0.6320.90
21_A29_D0.6280.90
111_I114_Q0.6280.90
86_I106_G0.6270.89
297_A303_F0.6250.89
231_I290_L0.6210.89
167_G228_S0.6210.89
138_W240_E0.6210.89
222_K226_N0.6210.89
172_T232_T0.6200.89
188_S295_E0.6200.89
184_A287_Y0.6200.89
34_T92_N0.6180.89
176_M254_N0.6170.89
6_I98_S0.6160.89
31_V34_T0.6150.89
131_A134_V0.6100.88
20_I135_F0.6080.88
6_I97_P0.6060.88
49_K81_K0.6030.88
203_P206_Y0.6020.87
278_L293_A0.6020.87
159_P165_D0.6010.87
239_M274_G0.6000.87
18_R46_Y0.5970.87
51_Y54_P0.5960.87
172_T230_V0.5950.87
43_I47_A0.5930.87
243_V311_V0.5930.87
4_I86_I0.5910.86
158_K164_K0.5910.86
160_K163_S0.5900.86
298_N310_L0.5890.86
233_H255_N0.5880.86
302_V307_T0.5880.86
82_K106_G0.5870.86
270_A273_L0.5850.86
102_F132_K0.5850.86
38_Y176_M0.5830.86
73_I77_S0.5830.86
251_M269_Y0.5820.86
202_D254_N0.5790.85
113_S137_H0.5790.85
78_A82_K0.5770.85
42_M216_F0.5750.85
254_N261_T0.5710.85
250_I293_A0.5690.84
33_P38_Y0.5680.84
183_D190_I0.5680.84
156_V196_I0.5670.84
6_I94_S0.5660.84
65_V79_S0.5650.84
198_T202_D0.5650.84
268_K272_I0.5620.84
171_V194_I0.5620.84
267_K279_S0.5610.84
176_M233_H0.5580.83
7_I37_P0.5580.83
157_E193_R0.5570.83
113_S236_K0.5550.83
224_I245_Y0.5550.83
57_R63_S0.5520.83
183_D188_S0.5470.82
160_K226_N0.5470.82
9_S92_N0.5470.82
29_D36_D0.5460.82
176_M200_K0.5460.82
5_L29_D0.5450.82
169_I229_L0.5450.82
77_S97_P0.5440.82
250_I278_L0.5430.82
190_I295_E0.5390.81
122_K125_G0.5390.81
185_I190_I0.5380.81
114_Q119_T0.5370.81
140_E143_K0.5370.81
54_P69_R0.5370.81
276_T297_A0.5360.81
33_P44_S0.5360.81
110_G113_S0.5350.81
189_V192_K0.5350.81
11_G216_F0.5330.80
202_D215_S0.5320.80
114_Q175_S0.5310.80
70_L126_I0.5310.80
253_Y262_T0.5300.80
66_L73_I0.5280.80
252_V285_S0.5270.80
18_R22_Q0.5240.79
260_A264_S0.5230.79
276_T307_T0.5220.79
266_A277_F0.5210.79
25_P48_N0.5190.79
66_L77_S0.5170.78
71_F79_S0.5170.78
192_K295_E0.5170.78
299_E303_F0.5150.78
306_G311_V0.5150.78
233_H254_N0.5140.78
206_Y213_T0.5130.78
99_F126_I0.5120.78
89_T93_H0.5100.77
72_S75_V0.5080.77
56_G63_S0.5060.77
126_I130_Y0.5060.77
248_P307_T0.5050.77
31_V35_N0.5030.76
302_V309_N0.5030.76
303_F311_V0.5020.76
295_E299_E0.5020.76
223_W227_A0.5010.76
234_Q239_M0.5000.76
299_E305_T0.5000.76
113_S237_T0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f0kA 2 0.9623 100 0.495 Contact Map
3s2uA 1 0.9214 100 0.5 Contact Map
2acvA 1 0.9528 100 0.526 Contact Map
2c1xA 1 0.956 100 0.533 Contact Map
2vchA 1 0.9591 100 0.537 Contact Map
3hbfA 1 0.9623 100 0.541 Contact Map
4relA 1 0.9497 100 0.553 Contact Map
3otgA 2 0.956 100 0.556 Contact Map
2iyaA 1 0.9434 100 0.556 Contact Map
3rscA 1 0.9623 100 0.56 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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