GREMLIN Database
OGT - Methylated-DNA--protein-cysteine methyltransferase
UniProt: Q97VW7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (143)
Sequences: 6152 (4570)
Seq/√Len: 382.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_A129_G3.1841.00
51_L57_P3.0191.00
140_A144_L2.7671.00
74_S99_T2.7401.00
78_E81_K2.7321.00
88_M96_S2.5691.00
91_K125_E2.3971.00
88_M92_Q2.2891.00
68_T76_F2.2391.00
19_D65_N2.1951.00
139_R143_E2.1131.00
8_K13_Y2.0491.00
78_E96_S2.0411.00
91_K95_D1.9711.00
78_E93_I1.9291.00
66_L117_I1.9111.00
19_D22_G1.8601.00
88_M93_I1.8031.00
5_G46_F1.8011.00
18_K42_F1.7781.00
16_V23_F1.6911.00
51_L56_K1.6881.00
6_L13_Y1.6501.00
48_K60_L1.6161.00
69_Y72_R1.6021.00
79_V108_L1.5951.00
26_L116_I1.5551.00
92_Q95_D1.5411.00
77_K80_M1.5051.00
72_R110_K1.4991.00
7_Y50_D1.4821.00
44_E48_K1.4781.00
75_V93_I1.4321.00
91_K101_P1.4181.00
48_K62_E1.4131.00
68_T72_R1.3991.00
19_D24_I1.3701.00
82_I88_M1.3551.00
81_K96_S1.3491.00
130_G135_V1.3371.00
82_I122_V1.3301.00
22_G65_N1.3161.00
88_M122_V1.3041.00
101_P105_G1.3001.00
140_A143_E1.2931.00
128_I135_V1.2831.00
78_E97_L1.2661.00
44_E47_H1.2581.00
28_F137_L1.2501.00
16_V45_F1.2381.00
109_S129_G1.2381.00
143_E146_G1.2261.00
106_M109_S1.2161.00
73_L77_K1.2121.00
17_A25_M1.1891.00
106_M110_K1.1801.00
46_F50_D1.1731.00
114_L133_R1.1671.00
10_P53_F1.1581.00
28_F114_L1.1471.00
66_L73_L1.0971.00
45_F116_I1.0881.00
106_M129_G1.0751.00
80_M117_I1.0561.00
64_I113_I1.0531.00
77_K81_K1.0491.00
66_L112_P1.0401.00
9_S14_I1.0341.00
48_K57_P1.0271.00
48_K61_R1.0221.00
62_E116_I1.0201.00
18_K39_D1.0161.00
38_D43_T1.0141.00
18_K45_F1.0131.00
9_S12_G1.0121.00
30_D137_L1.0101.00
6_L15_T0.9971.00
47_H51_L0.9941.00
7_Y46_F0.9871.00
21_K65_N0.9771.00
87_V142_L0.9701.00
71_F103_A0.9601.00
23_F45_F0.9561.00
66_L113_I0.9541.00
15_T29_C0.9491.00
70_P73_L0.9491.00
17_A24_I0.9481.00
50_D54_E0.9461.00
39_D42_F0.9421.00
129_G135_V0.9291.00
49_L53_F0.9261.00
108_L123_I0.9231.00
109_S134_G0.9141.00
136_K139_R0.9091.00
13_Y29_C0.9071.00
48_K58_I0.9071.00
11_L140_A0.8961.00
11_L137_L0.8881.00
137_L140_A0.8881.00
58_I84_W0.8781.00
97_L104_V0.8761.00
83_P86_K0.8741.00
5_G42_F0.8701.00
78_E88_M0.8681.00
105_G109_S0.8611.00
41_S44_E0.8501.00
52_Y144_L0.8461.00
24_I67_K0.8431.00
14_I26_L0.8411.00
108_L131_Y0.8411.00
109_S132_S0.8301.00
26_L49_L0.8281.00
15_T27_D0.8021.00
93_I108_L0.7931.00
72_R76_F0.7921.00
108_L114_L0.7871.00
70_P74_S0.7871.00
41_S63_P0.7831.00
18_K21_K0.7791.00
71_F107_A0.7791.00
42_F45_F0.7771.00
75_V97_L0.7761.00
31_C34_G0.7751.00
72_R106_M0.7751.00
11_L14_I0.7731.00
97_L100_S0.7721.00
100_S103_A0.7711.00
16_V42_F0.7671.00
124_A130_G0.7621.00
128_I139_R0.7581.00
114_L132_S0.7511.00
31_C35_N0.7451.00
5_G43_T0.7411.00
111_N119_C0.7391.00
16_V26_L0.7371.00
27_D114_L0.7341.00
143_E147_V0.7071.00
74_S77_K0.7071.00
93_I105_G0.6980.99
22_G41_S0.6970.99
71_F75_V0.6940.99
74_S97_L0.6900.99
26_L113_I0.6740.99
26_L114_L0.6730.99
18_K41_S0.6700.99
34_G37_R0.6690.99
41_S45_F0.6680.99
114_L137_L0.6680.99
115_L144_L0.6680.99
89_T125_E0.6550.99
57_P84_W0.6420.99
66_L76_F0.6420.99
50_D53_F0.6370.99
93_I104_V0.6370.99
67_K73_L0.6340.99
33_E37_R0.6300.99
75_V104_V0.6300.99
113_I117_I0.6260.99
6_L29_C0.6230.99
25_M114_L0.6220.99
45_F48_K0.6200.99
33_E36_S0.6120.99
22_G63_P0.6050.99
91_K105_G0.6040.99
24_I65_N0.6030.99
64_I80_M0.6030.99
135_V139_R0.6020.98
84_W144_L0.6020.98
76_F79_V0.6010.98
40_S43_T0.5990.98
7_Y14_I0.5980.98
14_I28_F0.5960.98
89_T92_Q0.5860.98
68_T73_L0.5840.98
49_L52_Y0.5830.98
87_V147_V0.5820.98
94_A104_V0.5800.98
79_V93_I0.5790.98
52_Y60_L0.5720.98
92_Q96_S0.5690.98
101_P106_M0.5680.98
49_L116_I0.5680.98
52_Y115_L0.5680.98
17_A27_D0.5670.98
82_I108_L0.5630.98
43_T47_H0.5630.98
115_L141_L0.5620.98
49_L115_L0.5610.98
55_G84_W0.5570.98
129_G132_S0.5550.97
47_H50_D0.5550.97
87_V123_I0.5510.97
113_I116_I0.5490.97
35_N38_D0.5470.97
124_A135_V0.5470.97
25_M105_G0.5450.97
53_F144_L0.5450.97
89_T124_A0.5430.97
7_Y16_V0.5430.97
51_L58_I0.5360.97
69_Y102_R0.5350.97
32_V36_S0.5340.97
32_V35_N0.5330.97
124_A128_I0.5270.97
9_S137_L0.5230.96
88_M108_L0.5230.96
66_L80_M0.5190.96
57_P61_R0.5170.96
48_K51_L0.5150.96
79_V122_V0.5140.96
131_Y137_L0.5130.96
71_F97_L0.5020.95
139_R146_G0.5020.95
93_I96_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wrjA 1 0.9868 100 0.117 Contact Map
1sfeA 1 0.9801 100 0.149 Contact Map
4bhbA 1 1 100 0.155 Contact Map
3l00A 1 0.9536 100 0.176 Contact Map
1eh6A 1 0.9536 100 0.178 Contact Map
1mgtA 1 0.9073 100 0.26 Contact Map
2g7hA 1 0.9603 100 0.263 Contact Map
2kifA 1 0.5563 100 0.413 Contact Map
3gvaA 1 0.5629 100 0.417 Contact Map
3ugoA 1 0.3841 81.1 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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