GREMLIN Database
Q97VW4 - Maleylacetate reductase (ClcE)
UniProt: Q97VW4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (291)
Sequences: 13644 (9549)
Seq/√Len: 559.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
248_K273_D3.3421.00
15_L140_R2.8341.00
44_E48_S2.7761.00
80_V92_I2.7471.00
191_D194_S2.5771.00
29_I79_V2.5691.00
147_K151_I2.5631.00
99_Y133_D2.5331.00
148_W237_V2.5311.00
26_G79_V2.5241.00
143_L195_I2.3311.00
16_N140_R2.3081.00
291_L294_A2.3041.00
47_L51_N2.2561.00
82_G92_I2.2211.00
188_C200_L2.2181.00
17_A20_W2.2081.00
274_K278_D2.1851.00
89_I102_A2.1461.00
70_L94_L2.0841.00
19_D45_Q2.0781.00
66_D69_N2.0561.00
44_E47_L2.0481.00
152_A237_V2.0401.00
57_G69_N2.0221.00
180_E183_K2.0211.00
36_S40_S2.0181.00
224_G238_T1.9871.00
194_S197_N1.9791.00
20_W23_S1.9091.00
59_R66_D1.8751.00
161_A181_G1.8731.00
196_E200_L1.8571.00
251_Y266_E1.8471.00
277_K283_R1.8401.00
137_L202_Q1.8341.00
284_R287_E1.8341.00
27_K78_D1.8171.00
74_L98_G1.8071.00
64_V68_N1.7881.00
38_L43_L1.7541.00
265_G268_L1.7521.00
247_I272_M1.7161.00
30_A73_R1.7011.00
32_V92_I1.6451.00
30_A74_L1.6441.00
270_E274_K1.6441.00
67_V91_G1.6421.00
29_I81_I1.6251.00
38_L56_E1.6251.00
297_Y301_F1.6091.00
150_L198_R1.5951.00
194_S198_R1.5811.00
294_A297_Y1.5771.00
266_E270_E1.5501.00
48_S52_A1.5361.00
101_I134_A1.5161.00
158_I182_Y1.5081.00
241_I288_F1.4931.00
15_L195_I1.4891.00
69_N72_E1.4751.00
140_R143_L1.4661.00
230_R297_Y1.4431.00
15_L143_L1.4421.00
82_G100_Y1.4361.00
155_V276_L1.4351.00
157_A185_L1.4351.00
67_V118_A1.4331.00
35_R39_K1.4321.00
176_S180_E1.4291.00
89_I110_A1.4121.00
204_G207_L1.4011.00
233_I238_T1.3961.00
203_I207_L1.3941.00
68_N72_E1.3771.00
273_D277_K1.3771.00
271_F274_K1.3731.00
48_S51_N1.3711.00
45_Q140_R1.3641.00
152_A234_P1.3521.00
67_V71_T1.3461.00
142_T198_R1.3371.00
74_L77_Y1.3361.00
297_Y300_T1.3251.00
223_F242_S1.3231.00
193_D196_E1.3191.00
154_G189_I1.3171.00
155_V281_A1.3151.00
59_R63_P1.3031.00
79_V101_I1.3031.00
65_G68_N1.3021.00
251_Y269_Y1.2991.00
18_L45_Q1.2881.00
46_I83_L1.2871.00
35_R56_E1.2851.00
35_R57_G1.2821.00
30_A77_Y1.2791.00
142_T202_Q1.2721.00
248_K251_Y1.2631.00
14_G20_W1.2561.00
71_T75_K1.2511.00
28_R78_D1.2481.00
180_E184_K1.2331.00
244_P273_D1.2281.00
192_L196_E1.2271.00
16_N19_D1.2141.00
146_P149_L1.2101.00
300_T304_I1.2041.00
213_R217_M1.2001.00
36_S39_K1.1831.00
14_G17_A1.1821.00
145_T149_L1.1791.00
82_G102_A1.1791.00
154_G201_C1.1741.00
251_Y265_G1.1721.00
213_R216_K1.1651.00
123_I126_S1.1611.00
233_I241_I1.1541.00
164_A167_S1.1481.00
19_D49_L1.1451.00
18_L141_A1.1241.00
21_L46_I1.1231.00
43_L47_L1.1141.00
195_I198_R1.1051.00
199_A203_I1.0951.00
45_Q49_L1.0901.00
38_L44_E1.0891.00
74_L80_V1.0871.00
17_A136_I1.0841.00
182_Y186_V1.0801.00
224_G228_G1.0801.00
15_L199_A1.0711.00
22_A49_L1.0691.00
72_E75_K1.0671.00
34_T37_L1.0661.00
177_L181_G1.0631.00
248_K266_E1.0621.00
64_V118_A1.0601.00
31_L47_L1.0581.00
69_N73_R1.0551.00
45_Q48_S1.0541.00
32_V58_P1.0541.00
173_F176_S1.0521.00
115_S128_I1.0491.00
12_I20_W1.0431.00
192_L198_R1.0401.00
122_G126_S1.0381.00
140_R195_I1.0331.00
183_K187_K1.0301.00
112_H135_I1.0241.00
201_C204_G1.0211.00
49_L52_A1.0211.00
37_L40_S1.0101.00
201_C205_T1.0021.00
11_V206_W0.9951.00
18_L103_I0.9921.00
38_L54_V0.9901.00
63_P66_D0.9871.00
107_F150_L0.9861.00
220_S243_L0.9861.00
185_L189_I0.9851.00
267_P270_E0.9831.00
31_L43_L0.9761.00
196_E199_A0.9751.00
219_I243_L0.9601.00
192_L195_I0.9591.00
264_E268_L0.9571.00
185_L188_C0.9561.00
301_F304_I0.9561.00
154_G157_A0.9531.00
112_H206_W0.9521.00
283_R287_E0.9511.00
38_L47_L0.9471.00
181_G185_L0.9441.00
230_R301_F0.9411.00
12_I134_A0.9401.00
246_T250_N0.9351.00
179_I183_K0.9331.00
147_K280_G0.9331.00
247_I269_Y0.9321.00
214_Y217_M0.9321.00
202_Q205_T0.9311.00
220_S239_S0.9301.00
200_L203_I0.9291.00
82_G89_I0.9261.00
186_V189_I0.9251.00
79_V99_Y0.9231.00
192_L197_N0.9221.00
26_G99_Y0.9211.00
65_G69_N0.9191.00
190_R194_S0.9141.00
191_D195_I0.9131.00
296_K300_T0.9121.00
296_K299_Q0.9101.00
102_A132_A0.9091.00
175_D178_A0.9091.00
165_L168_K0.9031.00
58_P91_G0.9021.00
184_K188_C0.9011.00
197_N201_C0.9001.00
187_K200_L0.8991.00
143_L193_D0.8961.00
241_I244_P0.8921.00
92_I100_Y0.8911.00
89_I104_P0.8891.00
203_I206_W0.8871.00
274_K277_K0.8861.00
55_I61_H0.8861.00
150_L192_L0.8851.00
248_K269_Y0.8841.00
197_N200_L0.8821.00
155_V240_C0.8791.00
188_C197_N0.8791.00
32_V94_L0.8761.00
240_C276_L0.8741.00
166_Y170_S0.8731.00
244_P276_L0.8721.00
198_R205_T0.8681.00
172_P175_D0.8661.00
231_F294_A0.8631.00
72_E122_G0.8581.00
68_N71_T0.8521.00
16_N138_D0.8491.00
269_Y273_D0.8481.00
171_T174_T0.8461.00
166_Y169_D0.8451.00
164_A211_T0.8421.00
193_D197_N0.8391.00
33_T38_L0.8371.00
61_H232_N0.8351.00
234_P237_V0.8311.00
263_N267_P0.8301.00
67_V94_L0.8221.00
159_D243_L0.8151.00
15_L139_P0.8121.00
198_R202_Q0.8111.00
36_S57_G0.8101.00
193_D198_R0.8101.00
282_K287_E0.8091.00
148_W152_A0.8061.00
221_H235_H0.8041.00
178_A181_G0.8031.00
209_S212_M0.8001.00
18_L140_R0.8001.00
139_P199_A0.7961.00
19_D140_R0.7931.00
34_T57_G0.7911.00
145_T153_S0.7911.00
28_R76_G0.7871.00
182_Y185_L0.7861.00
226_V301_F0.7861.00
198_R201_C0.7831.00
33_T88_V0.7821.00
299_Q303_Q0.7741.00
108_S157_A0.7741.00
223_F245_S0.7731.00
32_V70_L0.7681.00
61_H87_S0.7671.00
270_E273_D0.7661.00
154_G279_I0.7651.00
170_S174_T0.7641.00
42_I83_L0.7631.00
114_R130_K0.7611.00
245_S248_K0.7601.00
224_G239_S0.7591.00
223_F298_V0.7571.00
37_L42_I0.7531.00
205_T209_S0.7531.00
195_I199_A0.7511.00
181_G188_C0.7491.00
55_I70_L0.7481.00
292_D295_L0.7481.00
18_L138_D0.7411.00
190_R278_D0.7391.00
35_R38_L0.7381.00
186_V271_F0.7361.00
177_L180_E0.7331.00
22_A53_E0.7311.00
185_L201_C0.7281.00
21_L103_I0.7261.00
162_V268_L0.7231.00
70_L91_G0.7211.00
219_I246_T0.7211.00
149_L152_A0.7201.00
147_K190_R0.7151.00
67_V117_G0.7141.00
102_A135_I0.7081.00
161_A208_S0.7061.00
80_V98_G0.7051.00
243_L276_L0.7051.00
29_I78_D0.7011.00
273_D283_R0.6991.00
158_I162_V0.6991.00
190_R197_N0.6981.00
200_L205_T0.6981.00
176_S183_K0.6961.00
174_T178_A0.6961.00
195_I202_Q0.6921.00
151_I280_G0.6911.00
293_E296_K0.6901.00
227_Y238_T0.6891.00
200_L204_G0.6881.00
122_G232_N0.6881.00
190_R193_D0.6851.00
191_D198_R0.6821.00
158_I279_I0.6741.00
121_D125_K0.6741.00
12_I17_A0.6731.00
80_V95_S0.6711.00
55_I66_D0.6691.00
202_Q206_W0.6681.00
19_D52_A0.6641.00
55_I88_V0.6631.00
172_P176_S0.6621.00
247_I268_L0.6601.00
177_L207_L0.6551.00
167_S170_S0.6551.00
225_Y305_V0.6511.00
218_G225_Y0.6491.00
61_H66_D0.6471.00
184_K189_I0.6461.00
142_T150_L0.6451.00
169_D216_K0.6411.00
171_T175_D0.6401.00
21_L136_I0.6391.00
192_L199_A0.6371.00
148_W234_P0.6361.00
82_G88_V0.6351.00
120_I127_R0.6341.00
37_L43_L0.6311.00
45_Q141_A0.6291.00
121_D126_S0.6291.00
159_D220_S0.6281.00
126_S129_G0.6241.00
181_G184_K0.6231.00
169_D173_F0.6211.00
240_C281_A0.6211.00
81_I101_I0.6201.00
151_I154_G0.6201.00
70_L73_R0.6181.00
151_I281_A0.6181.00
59_R69_N0.6131.00
219_I222_N0.6121.00
248_K252_S0.6121.00
166_Y247_I0.6111.00
107_F202_Q0.6111.00
162_V272_M0.6091.00
32_V88_V0.6071.00
188_C196_E0.6041.00
49_L53_E0.6021.00
264_E267_P0.6021.00
277_K287_E0.6021.00
298_V302_I0.5981.00
28_R77_Y0.5951.00
217_M225_Y0.5951.00
184_K200_L0.5941.00
55_I69_N0.5931.00
17_A21_L0.5921.00
13_Y199_A0.5911.00
199_A205_T0.5911.00
63_P232_N0.5891.00
120_I123_I0.5871.00
239_S242_S0.5861.00
254_A263_N0.5821.00
42_I141_A0.5821.00
182_Y188_C0.5801.00
26_G78_D0.5801.00
100_Y133_D0.5791.00
44_E51_N0.5771.00
244_P248_K0.5771.00
169_D172_P0.5760.99
276_L281_A0.5750.99
12_I23_S0.5740.99
164_A175_D0.5730.99
42_I45_Q0.5730.99
301_F305_V0.5720.99
18_L46_I0.5710.99
219_I272_M0.5710.99
295_L299_Q0.5690.99
290_T295_L0.5690.99
164_A178_A0.5680.99
272_M276_L0.5660.99
26_G29_I0.5630.99
267_P271_F0.5630.99
46_I49_L0.5610.99
175_D179_I0.5590.99
147_K150_L0.5590.99
34_T40_S0.5590.99
277_K280_G0.5580.99
181_G208_S0.5560.99
13_Y203_I0.5550.99
107_F142_T0.5540.99
66_D91_G0.5540.99
165_L169_D0.5540.99
237_V282_K0.5520.99
33_T56_E0.5520.99
158_I275_F0.5510.99
273_D284_R0.5490.99
299_Q302_I0.5480.99
268_L272_M0.5460.99
208_S212_M0.5450.99
223_F226_V0.5450.99
103_I136_I0.5440.99
206_W210_L0.5430.99
149_L234_P0.5420.99
14_G139_P0.5420.99
212_M217_M0.5380.99
156_R235_H0.5370.99
162_V243_L0.5360.99
200_L207_L0.5360.99
188_C201_C0.5340.99
31_L83_L0.5330.99
80_V96_F0.5280.99
161_A178_A0.5270.99
210_L216_K0.5250.99
24_V134_A0.5230.99
185_L204_G0.5210.99
230_R294_A0.5200.99
36_S61_H0.5190.99
33_T37_L0.5170.99
19_D48_S0.5160.99
194_S201_C0.5160.99
47_L54_V0.5110.99
169_D174_T0.5100.99
155_V243_L0.5090.99
199_A202_Q0.5070.99
159_D239_S0.5070.99
191_D197_N0.5070.99
127_R130_K0.5060.99
244_P247_I0.5050.99
294_A298_V0.5040.99
228_G238_T0.5040.99
40_S43_L0.5040.99
73_R77_Y0.5020.99
275_F279_I0.5010.99
156_R221_H0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bfjA 5 0.9969 100 0.169 Contact Map
3ox4A 2 0.9969 100 0.169 Contact Map
1rrmA 2 0.9969 100 0.175 Contact Map
3zdrA 2 1 100 0.182 Contact Map
1vljA 2 1 100 0.182 Contact Map
3iv7A 2 0.9939 100 0.184 Contact Map
4fr2A 2 0.9969 100 0.187 Contact Map
3w5sA 2 0.9908 100 0.195 Contact Map
4qgsA 2 0.9817 100 0.197 Contact Map
3jzdA 3 0.9908 100 0.199 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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