GREMLIN Database
Q97VW1 - Lipase (LipP-1)
UniProt: Q97VW1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (256)
Sequences: 12671 (9757)
Seq/√Len: 609.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
111_R124_D4.3921.00
77_L125_S3.6491.00
146_A172_Y3.3021.00
267_V292_L2.9071.00
74_L148_A2.8611.00
251_E268_R2.5711.00
116_Y120_S2.5051.00
135_N138_K2.4851.00
129_T170_L2.4171.00
254_A264_V2.4061.00
176_I293_I2.3501.00
82_F155_N2.3491.00
257_L262_V2.2681.00
75_I128_A2.2501.00
161_A173_Q2.1891.00
254_A266_S2.1531.00
131_W135_N2.1101.00
87_V109_D2.1081.00
269_F292_L2.0601.00
106_V132_V2.0221.00
240_T250_G2.0111.00
236_A257_L2.0081.00
238_I254_A1.9701.00
173_Q236_A1.9581.00
174_I293_I1.9391.00
141_G144_G1.9191.00
108_V128_A1.9171.00
251_E266_S1.9001.00
175_L178_P1.8841.00
126_F163_L1.8831.00
62_V106_V1.8771.00
172_Y296_V1.8731.00
90_Y150_D1.8491.00
158_A253_Y1.8391.00
76_Y148_A1.8241.00
100_A291_G1.7951.00
64_L104_V1.7661.00
255_N259_Q1.7361.00
73_V106_V1.7351.00
125_S160_V1.7341.00
73_V132_V1.7171.00
61_R87_V1.6911.00
91_D95_R1.6891.00
254_A258_L1.6851.00
110_Y152_A1.6181.00
242_E270_N1.6121.00
94_C105_V1.6071.00
240_T268_R1.5961.00
75_I129_T1.5921.00
126_F164_S1.5801.00
122_V159_V1.5781.00
123_I163_L1.5651.00
146_A297_L1.5611.00
74_L103_C1.5551.00
71_Y104_V1.5531.00
163_L167_K1.5481.00
158_A175_L1.5421.00
147_I157_A1.5391.00
148_A174_I1.5391.00
163_L221_R1.5331.00
96_A100_A1.4991.00
165_K232_G1.4921.00
238_I250_G1.4891.00
258_L264_V1.4681.00
237_L267_V1.4621.00
173_Q253_Y1.4341.00
188_S248_D1.4221.00
100_A294_G1.4201.00
205_W209_Q1.4131.00
237_L296_V1.4041.00
60_A106_V1.3831.00
177_Y275_G1.3781.00
126_F130_N1.3641.00
77_L108_V1.3631.00
82_F179_A1.3531.00
172_Y237_L1.3521.00
240_T266_S1.3371.00
75_I132_V1.3181.00
256_R260_A1.3091.00
255_N258_L1.3061.00
256_R259_Q1.3041.00
283_I286_G1.2981.00
98_T105_V1.2911.00
54_S127_D1.2861.00
62_V104_V1.2831.00
291_G295_S1.2801.00
129_T160_V1.2771.00
49_I60_A1.2711.00
120_S124_D1.2541.00
265_T292_L1.2341.00
76_Y90_Y1.2241.00
60_A128_A1.2101.00
191_E247_R1.2051.00
252_A255_N1.2011.00
73_V104_V1.2001.00
50_K57_N1.1991.00
53_G56_A1.1941.00
247_R251_E1.1931.00
61_R91_D1.1821.00
94_C107_S1.1751.00
235_P263_P1.1721.00
129_T133_Y1.1641.00
130_N134_N1.1611.00
59_N109_D1.1241.00
223_S226_L1.1221.00
177_Y244_D1.1181.00
211_L222_F1.1021.00
269_F276_F1.0931.00
248_D251_E1.0891.00
118_F222_F1.0851.00
118_F210_Y1.0841.00
200_R204_E1.0801.00
78_H112_L1.0771.00
76_Y94_C1.0761.00
136_L139_F1.0731.00
288_D292_L1.0711.00
177_Y277_L1.0701.00
276_F289_A1.0521.00
285_Q288_D1.0501.00
111_R116_Y1.0501.00
71_Y102_N1.0391.00
183_D226_L1.0391.00
65_P71_Y1.0341.00
230_L233_L1.0291.00
182_F223_S1.0161.00
239_I289_A1.0161.00
272_V285_Q1.0161.00
70_P141_G1.0151.00
155_N159_V1.0111.00
113_A116_Y1.0091.00
247_R268_R1.0061.00
242_E268_R1.0011.00
157_A175_L0.9991.00
101_C294_G0.9971.00
158_A180_V0.9911.00
72_G144_G0.9901.00
74_L146_A0.9891.00
130_N167_K0.9891.00
212_R216_D0.9851.00
111_R120_S0.9851.00
49_I62_V0.9811.00
216_D219_D0.9691.00
158_A173_Q0.9641.00
121_A210_Y0.9641.00
125_S156_L0.9591.00
121_A156_L0.9471.00
77_L160_V0.9451.00
150_D177_Y0.9441.00
60_A131_W0.9431.00
48_D61_R0.9401.00
72_G103_C0.9381.00
136_L142_K0.9341.00
175_L238_I0.9231.00
239_I267_V0.9221.00
155_N210_Y0.9191.00
187_R191_E0.9161.00
154_G178_P0.9151.00
174_I297_L0.9121.00
252_A256_R0.9111.00
51_I58_I0.9061.00
129_T164_S0.9051.00
242_E271_N0.9041.00
158_A236_A0.9031.00
117_K121_A0.9031.00
180_V253_Y0.8951.00
161_A170_L0.8881.00
118_F219_D0.8851.00
82_F152_A0.8731.00
272_V276_F0.8691.00
157_A173_Q0.8651.00
77_L157_A0.8631.00
147_I160_V0.8591.00
80_G85_G0.8581.00
162_L221_R0.8581.00
45_K64_L0.8581.00
63_Y91_D0.8571.00
94_C98_T0.8561.00
162_L227_V0.8551.00
144_G171_K0.8511.00
166_G221_R0.8501.00
240_T247_R0.8331.00
196_F199_T0.8331.00
190_I200_R0.8311.00
68_N71_Y0.8301.00
77_L147_I0.8301.00
73_V145_V0.8281.00
218_L226_L0.8271.00
241_A276_F0.8251.00
275_G278_S0.8241.00
126_F160_V0.8241.00
118_F121_A0.8151.00
83_V113_A0.8121.00
269_F289_A0.8091.00
64_L71_Y0.8061.00
133_Y145_V0.8051.00
159_V221_R0.8041.00
113_A121_A0.8041.00
76_Y150_D0.7991.00
122_V163_L0.7981.00
179_A207_G0.7981.00
162_L233_L0.7981.00
175_L180_V0.7971.00
43_V99_N0.7971.00
181_G226_L0.7961.00
151_S274_H0.7941.00
230_L256_R0.7941.00
202_H206_F0.7921.00
113_A119_P0.7921.00
65_P104_V0.7891.00
126_F167_K0.7881.00
63_Y107_S0.7881.00
179_A203_I0.7851.00
237_L292_L0.7841.00
257_L264_V0.7831.00
269_F272_V0.7751.00
182_F207_G0.7741.00
190_I193_S0.7711.00
48_D87_V0.7681.00
238_I253_Y0.7591.00
240_T251_E0.7591.00
212_R217_L0.7581.00
292_L295_S0.7581.00
181_G223_S0.7571.00
229_D260_A0.7561.00
161_A236_A0.7511.00
48_D51_I0.7501.00
193_S196_F0.7411.00
53_G57_N0.7411.00
188_S191_E0.7391.00
195_G199_T0.7331.00
93_L277_L0.7301.00
152_A156_L0.7261.00
86_D89_S0.7261.00
51_I60_A0.7221.00
81_G206_F0.7161.00
129_T168_L0.7151.00
53_G58_I0.7151.00
118_F221_R0.7131.00
117_K120_S0.7121.00
178_P250_G0.7121.00
75_I160_V0.7041.00
133_Y168_L0.7041.00
51_I54_S0.7031.00
184_S204_E0.7031.00
265_T296_V0.7021.00
239_I277_L0.7001.00
76_Y107_S0.6961.00
188_S192_Y0.6921.00
187_R190_I0.6921.00
176_I277_L0.6911.00
198_L203_I0.6911.00
47_E64_L0.6891.00
241_A272_V0.6881.00
72_G141_G0.6881.00
173_Q233_L0.6851.00
86_D109_D0.6831.00
60_A108_V0.6801.00
239_I269_F0.6771.00
43_V66_K0.6761.00
150_D277_L0.6741.00
181_G249_Q0.6741.00
70_P137_D0.6731.00
84_I206_F0.6731.00
162_L230_L0.6721.00
179_A182_F0.6721.00
286_G290_I0.6711.00
86_D112_L0.6711.00
142_K145_V0.6701.00
211_L217_L0.6661.00
147_I173_Q0.6641.00
236_A253_Y0.6631.00
77_L129_T0.6591.00
117_K212_R0.6591.00
287_R291_G0.6551.00
295_S298_R0.6541.00
204_E208_S0.6521.00
154_G180_V0.6511.00
121_A124_D0.6471.00
61_R107_S0.6461.00
131_W139_F0.6461.00
50_K59_N0.6451.00
58_I128_A0.6441.00
87_V94_C0.6441.00
109_D112_L0.6401.00
258_L266_S0.6291.00
108_V125_S0.6291.00
148_A176_I0.6281.00
83_V209_Q0.6281.00
186_S252_A0.6251.00
251_E255_N0.6241.00
253_Y257_L0.6241.00
116_Y121_A0.6221.00
162_L165_K0.6201.00
122_V160_V0.6181.00
133_Y169_N0.6171.00
61_R88_E0.6161.00
93_L290_I0.6161.00
135_N139_F0.6151.00
177_Y241_A0.6121.00
137_D142_K0.6101.00
127_D130_N0.6041.00
199_T202_H0.6031.00
220_F228_Q0.6021.00
196_F243_Y0.5991.00
224_P227_V0.5971.00
239_I276_F0.5971.00
120_S123_I0.5961.00
207_G222_F0.5921.00
161_A233_L0.5881.00
162_L253_Y0.5841.00
237_L265_T0.5831.00
44_G98_T0.5811.00
288_D291_G0.5811.00
71_Y140_D0.5811.00
232_G262_V0.5801.00
150_D176_I0.5801.00
49_I138_K0.5781.00
102_N298_R0.5771.00
85_G112_L0.5761.00
119_P123_I0.5761.00
233_L253_Y0.5751.00
67_A71_Y0.5741.00
281_P287_R0.5731.00
192_Y195_G0.5711.00
284_E288_D0.5711.00
201_E205_W0.5711.00
135_N140_D0.5711.00
181_G184_S0.5701.00
56_A127_D0.5691.00
96_A99_N0.5651.00
82_F156_L0.5591.00
146_A171_K0.5561.00
97_I293_I0.5551.00
294_G298_R0.5541.00
171_K235_P0.5541.00
184_S189_M0.5541.00
77_L156_L0.5531.00
155_N179_A0.5490.99
180_V225_I0.5490.99
233_L236_A0.5480.99
129_T145_V0.5470.99
85_G89_S0.5460.99
63_Y87_V0.5440.99
208_S213_S0.5440.99
227_V230_L0.5440.99
106_V131_W0.5430.99
46_V49_I0.5430.99
213_S216_D0.5410.99
90_Y93_L0.5390.99
243_Y271_N0.5380.99
189_M249_Q0.5380.99
128_A131_W0.5370.99
55_E58_I0.5370.99
96_A290_I0.5350.99
150_D275_G0.5340.99
74_L97_I0.5340.99
104_V136_L0.5340.99
173_Q178_P0.5320.99
173_Q234_P0.5320.99
161_A234_P0.5290.99
249_Q252_A0.5280.99
75_I108_V0.5280.99
222_F226_L0.5270.99
103_C298_R0.5250.99
133_Y142_K0.5250.99
122_V156_L0.5210.99
130_N164_S0.5190.99
123_I127_D0.5190.99
289_A293_I0.5190.99
201_E204_E0.5170.99
93_L97_I0.5160.99
122_V221_R0.5150.99
168_L171_K0.5140.99
74_L105_V0.5120.99
165_K229_D0.5070.99
242_E247_R0.5060.99
82_F125_S0.5060.99
49_I53_G0.5020.99
193_S200_R0.5020.99
154_G179_A0.5010.99
240_T244_D0.5010.99
284_E287_R0.5010.99
58_I108_V0.5000.99
51_I128_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hm7A 2 0.9803 100 0.288 Contact Map
4wy8A 2 0.9934 100 0.294 Contact Map
3wj1A 4 0.9967 100 0.295 Contact Map
1lzlA 1 0.9836 100 0.297 Contact Map
2c7bA 3 0.9311 100 0.297 Contact Map
3zwqA 4 0.9869 100 0.299 Contact Map
4wy5A 2 1 100 0.345 Contact Map
4ob7A 2 0.9967 100 0.346 Contact Map
4xvcA 1 0.9574 100 0.357 Contact Map
4c89A 2 0.9574 100 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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