Q97VW1 - SULSO - GREMLIN Contacts

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Q97VW1 - Lipase (LipP-1)

UniProt:	Q97VW1	Sequences: MPLDPRIKELLESGFIVPIGKASVDEVRKIFRQLASAAPKVEVGKVEDIKIPGSEANINARVYLPKANGPYGVLIYLHGGGFVIGDVESYDPLCRAITNACNCVVVSVDYRLAPEYKFPSAVIDSFDATNWVYNNLDKFDGKMGVAIAGDSAGGNLAAVVALLSKGKLNLKYQILIYPAVGFDSVSRSMIEYSDGFFLTREHIEWFGSQYLRSPADLLDFRFSPILVQDLSGLPPALIITAEYDPLRDQGEAYANRLLQAGVPVTSVRFNNVIHGFLSFFPLIEQGRDAIGLIGSVLRRAFYDKS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	305 (256)
Sequences:	12671 (9757)
Seq/√Len:	609.8

ECOLI - AES
BACSU - YTMA
SULSO - Q97VW1 Q97VT8 Q97VU2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
111_R	124_D	4.392	1.00
77_L	125_S	3.649	1.00
146_A	172_Y	3.302	1.00
267_V	292_L	2.907	1.00
74_L	148_A	2.861	1.00
251_E	268_R	2.571	1.00
116_Y	120_S	2.505	1.00
135_N	138_K	2.485	1.00
129_T	170_L	2.417	1.00
254_A	264_V	2.406	1.00
176_I	293_I	2.350	1.00
82_F	155_N	2.349	1.00
257_L	262_V	2.268	1.00
75_I	128_A	2.250	1.00
161_A	173_Q	2.189	1.00
254_A	266_S	2.153	1.00
131_W	135_N	2.110	1.00
87_V	109_D	2.108	1.00
269_F	292_L	2.060	1.00
106_V	132_V	2.022	1.00
240_T	250_G	2.011	1.00
236_A	257_L	2.008	1.00
238_I	254_A	1.970	1.00
173_Q	236_A	1.958	1.00
174_I	293_I	1.939	1.00
141_G	144_G	1.919	1.00
108_V	128_A	1.917	1.00
251_E	266_S	1.900	1.00
175_L	178_P	1.884	1.00
126_F	163_L	1.883	1.00
62_V	106_V	1.877	1.00
172_Y	296_V	1.873	1.00
90_Y	150_D	1.849	1.00
158_A	253_Y	1.839	1.00
76_Y	148_A	1.824	1.00
100_A	291_G	1.795	1.00
64_L	104_V	1.766	1.00
255_N	259_Q	1.736	1.00
73_V	106_V	1.735	1.00
125_S	160_V	1.734	1.00
73_V	132_V	1.717	1.00
61_R	87_V	1.691	1.00
91_D	95_R	1.689	1.00
254_A	258_L	1.685	1.00
110_Y	152_A	1.618	1.00
242_E	270_N	1.612	1.00
94_C	105_V	1.607	1.00
240_T	268_R	1.596	1.00
75_I	129_T	1.592	1.00
126_F	164_S	1.580	1.00
122_V	159_V	1.578	1.00
123_I	163_L	1.565	1.00
146_A	297_L	1.561	1.00
74_L	103_C	1.555	1.00
71_Y	104_V	1.553	1.00
163_L	167_K	1.548	1.00
158_A	175_L	1.542	1.00
147_I	157_A	1.539	1.00
148_A	174_I	1.539	1.00
163_L	221_R	1.533	1.00
96_A	100_A	1.499	1.00
165_K	232_G	1.492	1.00
238_I	250_G	1.489	1.00
258_L	264_V	1.468	1.00
237_L	267_V	1.462	1.00
173_Q	253_Y	1.434	1.00
188_S	248_D	1.422	1.00
100_A	294_G	1.420	1.00
205_W	209_Q	1.413	1.00
237_L	296_V	1.404	1.00
60_A	106_V	1.383	1.00
177_Y	275_G	1.378	1.00
126_F	130_N	1.364	1.00
77_L	108_V	1.363	1.00
82_F	179_A	1.353	1.00
172_Y	237_L	1.352	1.00
240_T	266_S	1.337	1.00
75_I	132_V	1.318	1.00
256_R	260_A	1.309	1.00
255_N	258_L	1.306	1.00
256_R	259_Q	1.304	1.00
283_I	286_G	1.298	1.00
98_T	105_V	1.291	1.00
54_S	127_D	1.286	1.00
62_V	104_V	1.283	1.00
291_G	295_S	1.280	1.00
129_T	160_V	1.277	1.00
49_I	60_A	1.271	1.00
120_S	124_D	1.254	1.00
265_T	292_L	1.234	1.00
76_Y	90_Y	1.224	1.00
60_A	128_A	1.210	1.00
191_E	247_R	1.205	1.00
252_A	255_N	1.201	1.00
73_V	104_V	1.200	1.00
50_K	57_N	1.199	1.00
53_G	56_A	1.194	1.00
247_R	251_E	1.193	1.00
61_R	91_D	1.182	1.00
94_C	107_S	1.175	1.00
235_P	263_P	1.172	1.00
129_T	133_Y	1.164	1.00
130_N	134_N	1.161	1.00
59_N	109_D	1.124	1.00
223_S	226_L	1.122	1.00
177_Y	244_D	1.118	1.00
211_L	222_F	1.102	1.00
269_F	276_F	1.093	1.00
248_D	251_E	1.089	1.00
118_F	222_F	1.085	1.00
118_F	210_Y	1.084	1.00
200_R	204_E	1.080	1.00
78_H	112_L	1.077	1.00
76_Y	94_C	1.076	1.00
136_L	139_F	1.073	1.00
288_D	292_L	1.071	1.00
177_Y	277_L	1.070	1.00
276_F	289_A	1.052	1.00
285_Q	288_D	1.050	1.00
111_R	116_Y	1.050	1.00
71_Y	102_N	1.039	1.00
183_D	226_L	1.039	1.00
65_P	71_Y	1.034	1.00
230_L	233_L	1.029	1.00
182_F	223_S	1.016	1.00
239_I	289_A	1.016	1.00
272_V	285_Q	1.016	1.00
70_P	141_G	1.015	1.00
155_N	159_V	1.011	1.00
113_A	116_Y	1.009	1.00
247_R	268_R	1.006	1.00
242_E	268_R	1.001	1.00
157_A	175_L	0.999	1.00
101_C	294_G	0.997	1.00
158_A	180_V	0.991	1.00
72_G	144_G	0.990	1.00
74_L	146_A	0.989	1.00
130_N	167_K	0.989	1.00
212_R	216_D	0.985	1.00
111_R	120_S	0.985	1.00
49_I	62_V	0.981	1.00
216_D	219_D	0.969	1.00
158_A	173_Q	0.964	1.00
121_A	210_Y	0.964	1.00
125_S	156_L	0.959	1.00
121_A	156_L	0.947	1.00
77_L	160_V	0.945	1.00
150_D	177_Y	0.944	1.00
60_A	131_W	0.943	1.00
48_D	61_R	0.940	1.00
72_G	103_C	0.938	1.00
136_L	142_K	0.934	1.00
175_L	238_I	0.923	1.00
239_I	267_V	0.922	1.00
155_N	210_Y	0.919	1.00
187_R	191_E	0.916	1.00
154_G	178_P	0.915	1.00
174_I	297_L	0.912	1.00
252_A	256_R	0.911	1.00
51_I	58_I	0.906	1.00
129_T	164_S	0.905	1.00
242_E	271_N	0.904	1.00
158_A	236_A	0.903	1.00
117_K	121_A	0.903	1.00
180_V	253_Y	0.895	1.00
161_A	170_L	0.888	1.00
118_F	219_D	0.885	1.00
82_F	152_A	0.873	1.00
272_V	276_F	0.869	1.00
157_A	173_Q	0.865	1.00
77_L	157_A	0.863	1.00
147_I	160_V	0.859	1.00
80_G	85_G	0.858	1.00
162_L	221_R	0.858	1.00
45_K	64_L	0.858	1.00
63_Y	91_D	0.857	1.00
94_C	98_T	0.856	1.00
162_L	227_V	0.855	1.00
144_G	171_K	0.851	1.00
166_G	221_R	0.850	1.00
240_T	247_R	0.833	1.00
196_F	199_T	0.833	1.00
190_I	200_R	0.831	1.00
68_N	71_Y	0.830	1.00
77_L	147_I	0.830	1.00
73_V	145_V	0.828	1.00
218_L	226_L	0.827	1.00
241_A	276_F	0.825	1.00
275_G	278_S	0.824	1.00
126_F	160_V	0.824	1.00
118_F	121_A	0.815	1.00
83_V	113_A	0.812	1.00
269_F	289_A	0.809	1.00
64_L	71_Y	0.806	1.00
133_Y	145_V	0.805	1.00
159_V	221_R	0.804	1.00
113_A	121_A	0.804	1.00
76_Y	150_D	0.799	1.00
122_V	163_L	0.798	1.00
179_A	207_G	0.798	1.00
162_L	233_L	0.798	1.00
175_L	180_V	0.797	1.00
43_V	99_N	0.797	1.00
181_G	226_L	0.796	1.00
151_S	274_H	0.794	1.00
230_L	256_R	0.794	1.00
202_H	206_F	0.792	1.00
113_A	119_P	0.792	1.00
65_P	104_V	0.789	1.00
126_F	167_K	0.788	1.00
63_Y	107_S	0.788	1.00
179_A	203_I	0.785	1.00
237_L	292_L	0.784	1.00
257_L	264_V	0.783	1.00
269_F	272_V	0.775	1.00
182_F	207_G	0.774	1.00
190_I	193_S	0.771	1.00
48_D	87_V	0.768	1.00
238_I	253_Y	0.759	1.00
240_T	251_E	0.759	1.00
212_R	217_L	0.758	1.00
292_L	295_S	0.758	1.00
181_G	223_S	0.757	1.00
229_D	260_A	0.756	1.00
161_A	236_A	0.751	1.00
48_D	51_I	0.750	1.00
193_S	196_F	0.741	1.00
53_G	57_N	0.741	1.00
188_S	191_E	0.739	1.00
195_G	199_T	0.733	1.00
93_L	277_L	0.730	1.00
152_A	156_L	0.726	1.00
86_D	89_S	0.726	1.00
51_I	60_A	0.722	1.00
81_G	206_F	0.716	1.00
129_T	168_L	0.715	1.00
53_G	58_I	0.715	1.00
118_F	221_R	0.713	1.00
117_K	120_S	0.712	1.00
178_P	250_G	0.712	1.00
75_I	160_V	0.704	1.00
133_Y	168_L	0.704	1.00
51_I	54_S	0.703	1.00
184_S	204_E	0.703	1.00
265_T	296_V	0.702	1.00
239_I	277_L	0.700	1.00
76_Y	107_S	0.696	1.00
188_S	192_Y	0.692	1.00
187_R	190_I	0.692	1.00
176_I	277_L	0.691	1.00
198_L	203_I	0.691	1.00
47_E	64_L	0.689	1.00
241_A	272_V	0.688	1.00
72_G	141_G	0.688	1.00
173_Q	233_L	0.685	1.00
86_D	109_D	0.683	1.00
60_A	108_V	0.680	1.00
239_I	269_F	0.677	1.00
43_V	66_K	0.676	1.00
150_D	277_L	0.674	1.00
181_G	249_Q	0.674	1.00
70_P	137_D	0.673	1.00
84_I	206_F	0.673	1.00
162_L	230_L	0.672	1.00
179_A	182_F	0.672	1.00
286_G	290_I	0.671	1.00
86_D	112_L	0.671	1.00
142_K	145_V	0.670	1.00
211_L	217_L	0.666	1.00
147_I	173_Q	0.664	1.00
236_A	253_Y	0.663	1.00
77_L	129_T	0.659	1.00
117_K	212_R	0.659	1.00
287_R	291_G	0.655	1.00
295_S	298_R	0.654	1.00
204_E	208_S	0.652	1.00
154_G	180_V	0.651	1.00
121_A	124_D	0.647	1.00
61_R	107_S	0.646	1.00
131_W	139_F	0.646	1.00
50_K	59_N	0.645	1.00
58_I	128_A	0.644	1.00
87_V	94_C	0.644	1.00
109_D	112_L	0.640	1.00
258_L	266_S	0.629	1.00
108_V	125_S	0.629	1.00
148_A	176_I	0.628	1.00
83_V	209_Q	0.628	1.00
186_S	252_A	0.625	1.00
251_E	255_N	0.624	1.00
253_Y	257_L	0.624	1.00
116_Y	121_A	0.622	1.00
162_L	165_K	0.620	1.00
122_V	160_V	0.618	1.00
133_Y	169_N	0.617	1.00
61_R	88_E	0.616	1.00
93_L	290_I	0.616	1.00
135_N	139_F	0.615	1.00
177_Y	241_A	0.612	1.00
137_D	142_K	0.610	1.00
127_D	130_N	0.604	1.00
199_T	202_H	0.603	1.00
220_F	228_Q	0.602	1.00
196_F	243_Y	0.599	1.00
224_P	227_V	0.597	1.00
239_I	276_F	0.597	1.00
120_S	123_I	0.596	1.00
207_G	222_F	0.592	1.00
161_A	233_L	0.588	1.00
162_L	253_Y	0.584	1.00
237_L	265_T	0.583	1.00
44_G	98_T	0.581	1.00
288_D	291_G	0.581	1.00
71_Y	140_D	0.581	1.00
232_G	262_V	0.580	1.00
150_D	176_I	0.580	1.00
49_I	138_K	0.578	1.00
102_N	298_R	0.577	1.00
85_G	112_L	0.576	1.00
119_P	123_I	0.576	1.00
233_L	253_Y	0.575	1.00
67_A	71_Y	0.574	1.00
281_P	287_R	0.573	1.00
192_Y	195_G	0.571	1.00
284_E	288_D	0.571	1.00
201_E	205_W	0.571	1.00
135_N	140_D	0.571	1.00
181_G	184_S	0.570	1.00
56_A	127_D	0.569	1.00
96_A	99_N	0.565	1.00
82_F	156_L	0.559	1.00
146_A	171_K	0.556	1.00
97_I	293_I	0.555	1.00
294_G	298_R	0.554	1.00
171_K	235_P	0.554	1.00
184_S	189_M	0.554	1.00
77_L	156_L	0.553	1.00
155_N	179_A	0.549	0.99
180_V	225_I	0.549	0.99
233_L	236_A	0.548	0.99
129_T	145_V	0.547	0.99
85_G	89_S	0.546	0.99
63_Y	87_V	0.544	0.99
208_S	213_S	0.544	0.99
227_V	230_L	0.544	0.99
106_V	131_W	0.543	0.99
46_V	49_I	0.543	0.99
213_S	216_D	0.541	0.99
90_Y	93_L	0.539	0.99
243_Y	271_N	0.538	0.99
189_M	249_Q	0.538	0.99
128_A	131_W	0.537	0.99
55_E	58_I	0.537	0.99
96_A	290_I	0.535	0.99
150_D	275_G	0.534	0.99
74_L	97_I	0.534	0.99
104_V	136_L	0.534	0.99
173_Q	178_P	0.532	0.99
173_Q	234_P	0.532	0.99
161_A	234_P	0.529	0.99
249_Q	252_A	0.528	0.99
75_I	108_V	0.528	0.99
222_F	226_L	0.527	0.99
103_C	298_R	0.525	0.99
133_Y	142_K	0.525	0.99
122_V	156_L	0.521	0.99
130_N	164_S	0.519	0.99
123_I	127_D	0.519	0.99
289_A	293_I	0.519	0.99
201_E	204_E	0.517	0.99
93_L	97_I	0.516	0.99
122_V	221_R	0.515	0.99
168_L	171_K	0.514	0.99
74_L	105_V	0.512	0.99
165_K	229_D	0.507	0.99
242_E	247_R	0.506	0.99
82_F	125_S	0.506	0.99
49_I	53_G	0.502	0.99
193_S	200_R	0.502	0.99
154_G	179_A	0.501	0.99
240_T	244_D	0.501	0.99
284_E	287_R	0.501	0.99
58_I	108_V	0.500	0.99
51_I	128_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2hm7A	2	0.9803	100	0.288	Contact Map
4wy8A	2	0.9934	100	0.294	Contact Map
3wj1A	4	0.9967	100	0.295	Contact Map
1lzlA	1	0.9836	100	0.297	Contact Map
2c7bA	3	0.9311	100	0.297	Contact Map
3zwqA	4	0.9869	100	0.299	Contact Map
4wy5A	2	1	100	0.345	Contact Map
4ob7A	2	0.9967	100	0.346	Contact Map
4xvcA	1	0.9574	100	0.357	Contact Map
4c89A	2	0.9574	100	0.363	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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