Q97VW0 - SULSO - GREMLIN Contacts

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Q97VW0 - Alcohol dehydrogenase (Zn containing) (Adh-8)

UniProt:	Q97VW0	Sequences: MKAVILPAHKQGYRIEEVPDPKPGKDEAIIKVNKAALCYRDLLQIKGFYPRSKYPLILGHEVVGTVEEVGEDVKDFKKGDRVTSMLFVPDWSCEYCKSGEEVYCKNRVVYAQELDGFFAEKAKVKASSLVKVPESVSDEGAVIVPCVAAMVYRGLKKAGIKKGEIVLVTGASGGVGIHAIQVAKALGAKVIGVTSGESKAKIVSKYADYVIVGEKFSEEAKKIGDVSIVIENVGPYTLEESMKSLRSGGKIIQIGNLDPSVTFNLRLGYIILKDISLMGHIGANKNDIIKTLNLVKEGKIKPVIGSEVSLENFGKALDLLNDSKNRYGKILISNSF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	336 (299)
Sequences:	52778 (36249)
Seq/√Len:	2096.3

ECOLI - YBDR AHR ADHP YAHK RSPB YDJL YPHC FRMA TDH GATD YGGP YJJN YDJJ IDND QOR1 ACUI YCJQ CURA
BACSU - ADHB YJMD ADHA YOGA YYCR DHSO BDHA TDH YHFP YFMJ
HALSA - Q9HP38 Q9HMB6 GLCDH Q9HR85 Q9HQS8
SULSO - Q97VW0 Q7LXK1 ADH Q97YT7 Q97ZV3 Q97VV5 Q97WA1 Q97XR4 Q97V32 Q97YM2 GLCD2 GLCD3 GLCD1 Q97TZ4 Q97W06 Q97UW5 Q97VB8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_N	138_D	3.058	1.00
31_K	67_E	2.989	1.00
33_N	65_T	2.894	1.00
312_N	315_K	2.780	1.00
165_I	189_K	2.664	1.00
7_P	16_E	2.593	1.00
29_I	67_E	2.527	1.00
77_K	80_D	2.487	1.00
81_R	132_V	2.399	1.00
80_D	131_K	2.394	1.00
171_A	192_G	2.357	1.00
28_A	129_L	2.324	1.00
20_D	121_K	2.302	1.00
7_P	14_R	2.286	1.00
137_S	140_G	2.276	1.00
308_V	319_L	2.276	1.00
161_K	164_E	2.264	1.00
184_K	208_D	2.236	1.00
31_K	121_K	2.210	1.00
31_K	65_T	2.196	1.00
166_V	183_A	2.169	1.00
139_E	307_E	2.136	1.00
306_S	319_L	2.109	1.00
219_E	222_K	2.088	1.00
5_I	16_E	2.082	1.00
189_K	209_Y	2.075	1.00
24_G	27_E	2.069	1.00
62_V	84_S	2.063	1.00
200_A	204_S	2.043	1.00
25_K	71_E	2.033	1.00
25_K	72_D	1.998	1.00
75_D	126_A	1.994	1.00
29_I	123_K	1.973	1.00
309_S	312_N	1.969	1.00
135_S	296_K	1.961	1.00
67_E	121_K	1.947	1.00
201_K	205_K	1.946	1.00
62_V	117_F	1.914	1.00
46_K	321_N	1.908	1.00
293_N	297_E	1.895	1.00
26_D	72_D	1.888	1.00
201_K	204_S	1.856	1.00
318_D	322_D	1.849	1.00
180_I	207_A	1.838	1.00
200_A	210_V	1.836	1.00
63_V	138_D	1.808	1.00
81_R	138_D	1.806	1.00
250_K	276_S	1.795	1.00
185_A	299_K	1.789	1.00
167_L	193_V	1.762	1.00
319_L	324_K	1.723	1.00
227_S	246_R	1.712	1.00
132_V	138_D	1.677	1.00
250_K	278_M	1.675	1.00
197_E	201_K	1.672	1.00
167_L	226_V	1.669	1.00
191_I	226_V	1.654	1.00
315_K	318_D	1.627	1.00
315_K	319_L	1.604	1.00
202_I	205_K	1.604	1.00
148_A	178_H	1.601	1.00
194_T	200_A	1.601	1.00
132_V	141_A	1.587	1.00
29_I	121_K	1.578	1.00
4_V	313_F	1.576	1.00
308_V	316_A	1.565	1.00
305_G	319_L	1.562	1.00
22_K	68_E	1.555	1.00
65_T	81_R	1.549	1.00
209_Y	223_I	1.509	1.00
169_T	241_S	1.504	1.00
245_L	251_I	1.501	1.00
68_E	78_K	1.499	1.00
195_S	213_G	1.499	1.00
140_G	301_K	1.497	1.00
314_G	318_D	1.479	1.00
69_V	78_K	1.474	1.00
229_V	245_L	1.468	1.00
158_A	228_I	1.465	1.00
29_I	68_E	1.465	1.00
245_L	275_I	1.457	1.00
26_D	125_K	1.454	1.00
27_E	125_K	1.441	1.00
76_F	131_K	1.435	1.00
76_F	80_D	1.430	1.00
32_V	62_V	1.423	1.00
189_K	208_D	1.416	1.00
118_F	317_L	1.405	1.00
27_E	123_K	1.403	1.00
245_L	249_G	1.391	1.00
70_G	73_V	1.380	1.00
164_E	250_K	1.371	1.00
197_E	212_V	1.363	1.00
81_R	134_E	1.361	1.00
3_A	18_V	1.357	1.00
34_K	139_E	1.349	1.00
229_V	241_S	1.339	1.00
212_V	215_K	1.338	1.00
293_N	296_K	1.328	1.00
185_A	294_L	1.325	1.00
65_T	138_D	1.318	1.00
23_P	123_K	1.316	1.00
165_I	191_I	1.314	1.00
23_P	29_I	1.301	1.00
28_A	76_F	1.300	1.00
4_V	15_I	1.295	1.00
197_E	215_K	1.285	1.00
66_V	76_F	1.275	1.00
169_T	193_V	1.271	1.00
179_A	230_I	1.270	1.00
45_I	317_L	1.250	1.00
33_N	81_R	1.248	1.00
219_E	223_I	1.228	1.00
180_I	192_G	1.215	1.00
156_K	287_D	1.207	1.00
32_V	122_A	1.207	1.00
218_E	222_K	1.189	1.00
20_D	29_I	1.184	1.00
200_A	212_V	1.169	1.00
76_F	129_L	1.168	1.00
144_V	295_V	1.166	1.00
165_I	227_S	1.164	1.00
26_D	126_A	1.151	1.00
5_I	18_V	1.122	1.00
294_L	299_K	1.115	1.00
160_I	188_A	1.113	1.00
164_E	227_S	1.105	1.00
243_K	269_Y	1.096	1.00
217_S	221_K	1.085	1.00
197_E	200_A	1.077	1.00
290_K	293_N	1.074	1.00
204_S	210_V	1.072	1.00
202_I	327_Y	1.070	1.00
156_K	290_K	1.070	1.00
8_A	12_G	1.065	1.00
124_V	129_L	1.053	1.00
183_A	188_A	1.043	1.00
153_R	287_D	1.040	1.00
15_I	311_E	1.039	1.00
151_V	179_A	1.035	1.00
30_I	82_V	1.034	1.00
35_A	118_F	1.032	1.00
195_S	214_E	1.031	1.00
136_V	141_A	1.030	1.00
313_F	332_I	1.028	1.00
217_S	243_K	1.028	1.00
191_I	209_Y	1.027	1.00
45_I	321_N	1.024	1.00
160_I	164_E	1.016	1.00
34_K	138_D	1.013	1.00
158_A	252_I	1.006	1.00
73_V	126_A	0.998	1.00
4_V	310_L	0.996	1.00
30_I	64_G	0.996	1.00
233_V	237_T	0.992	1.00
37_L	316_A	0.991	1.00
157_K	276_S	0.989	1.00
67_E	78_K	0.986	1.00
318_D	321_N	0.984	1.00
204_S	209_Y	0.981	1.00
154_G	254_I	0.973	1.00
9_H	54_Y	0.971	1.00
205_K	302_P	0.963	1.00
240_E	243_K	0.962	1.00
152_Y	290_K	0.956	1.00
217_S	240_E	0.951	1.00
289_I	293_N	0.951	1.00
23_P	27_E	0.950	1.00
290_K	294_L	0.936	1.00
192_G	207_A	0.934	1.00
308_V	312_N	0.931	1.00
319_L	330_I	0.929	1.00
215_K	219_E	0.928	1.00
171_A	194_T	0.927	1.00
154_G	230_I	0.926	1.00
239_E	243_K	0.923	1.00
192_G	203_V	0.922	1.00
269_Y	273_K	0.919	1.00
171_A	180_I	0.912	1.00
83_T	292_L	0.912	1.00
74_K	126_A	0.912	1.00
171_A	203_V	0.911	1.00
118_F	313_F	0.911	1.00
248_G	274_D	0.910	1.00
207_A	210_V	0.907	1.00
157_K	278_M	0.903	1.00
151_V	182_V	0.902	1.00
42_L	320_L	0.901	1.00
194_T	210_V	0.898	1.00
164_E	228_I	0.897	1.00
56_L	115_D	0.896	1.00
34_K	331_L	0.893	1.00
231_E	234_G	0.893	1.00
7_P	12_G	0.892	1.00
177_I	202_I	0.879	1.00
193_V	213_G	0.879	1.00
69_V	77_K	0.874	1.00
180_I	190_V	0.873	1.00
198_S	201_K	0.871	1.00
199_K	327_Y	0.870	1.00
33_N	63_V	0.869	1.00
4_V	13_Y	0.861	1.00
167_L	244_S	0.855	1.00
196_G	199_K	0.855	1.00
35_A	117_F	0.855	1.00
169_T	229_V	0.852	1.00
20_D	68_E	0.851	1.00
38_C	61_E	0.849	1.00
191_I	211_I	0.849	1.00
5_I	57_I	0.847	1.00
3_A	57_I	0.846	1.00
286_N	290_K	0.843	1.00
31_K	120_E	0.841	1.00
236_Y	240_E	0.837	1.00
8_A	11_Q	0.835	1.00
196_G	212_V	0.834	1.00
168_V	183_A	0.834	1.00
69_V	73_V	0.831	1.00
159_G	250_K	0.830	1.00
306_S	315_K	0.824	1.00
20_D	67_E	0.816	1.00
183_A	190_V	0.816	1.00
149_A	287_D	0.815	1.00
195_S	200_A	0.806	1.00
130_V	289_I	0.803	1.00
62_V	122_A	0.799	1.00
117_F	122_A	0.793	1.00
286_N	289_I	0.793	1.00
260_S	264_N	0.790	1.00
38_C	60_H	0.787	1.00
28_A	126_A	0.784	1.00
168_V	179_A	0.784	1.00
22_K	29_I	0.782	1.00
166_V	188_A	0.780	1.00
229_V	251_I	0.780	1.00
18_V	115_D	0.780	1.00
220_A	226_V	0.773	1.00
182_V	291_T	0.772	1.00
77_K	131_K	0.770	1.00
218_E	221_K	0.769	1.00
84_S	124_V	0.767	1.00
190_V	208_D	0.763	1.00
232_N	254_I	0.762	1.00
241_S	251_I	0.761	1.00
294_L	297_E	0.761	1.00
37_L	320_L	0.760	1.00
36_A	61_E	0.760	1.00
133_P	296_K	0.756	1.00
270_I	277_L	0.756	1.00
239_E	269_Y	0.755	1.00
169_T	237_T	0.754	1.00
18_V	57_I	0.752	1.00
24_G	123_K	0.748	1.00
38_C	41_D	0.748	1.00
304_I	307_E	0.747	1.00
308_V	330_I	0.747	1.00
165_I	224_G	0.744	1.00
118_F	332_I	0.741	1.00
151_V	178_H	0.736	1.00
266_R	269_Y	0.735	1.00
203_V	207_A	0.734	1.00
216_F	240_E	0.733	1.00
134_E	296_K	0.731	1.00
165_I	226_V	0.731	1.00
186_L	290_K	0.729	1.00
63_V	142_V	0.726	1.00
40_R	60_H	0.723	1.00
182_V	294_L	0.722	1.00
155_L	183_A	0.722	1.00
82_V	129_L	0.720	1.00
319_L	322_D	0.719	1.00
159_G	276_S	0.711	1.00
83_T	132_V	0.704	1.00
154_G	179_A	0.702	1.00
194_T	203_V	0.701	1.00
15_I	310_L	0.698	1.00
177_I	303_V	0.698	1.00
202_I	303_V	0.696	1.00
4_V	314_G	0.696	1.00
270_I	275_I	0.694	1.00
136_V	295_V	0.693	1.00
34_K	307_E	0.692	1.00
26_D	70_G	0.692	1.00
292_L	296_K	0.691	1.00
159_G	278_M	0.690	1.00
326_R	330_I	0.688	1.00
26_D	127_S	0.687	1.00
168_V	192_G	0.686	1.00
204_S	207_A	0.686	1.00
152_Y	294_L	0.686	1.00
181_Q	301_K	0.685	1.00
26_D	71_E	0.683	1.00
253_Q	277_L	0.683	1.00
320_L	330_I	0.680	1.00
42_L	321_N	0.676	1.00
188_A	228_I	0.676	1.00
23_P	68_E	0.675	1.00
160_I	228_I	0.675	1.00
32_V	35_A	0.673	1.00
191_I	220_A	0.672	1.00
181_Q	206_Y	0.671	1.00
270_I	279_G	0.669	1.00
148_A	291_T	0.668	1.00
191_I	223_I	0.664	1.00
130_V	288_I	0.662	1.00
156_K	186_L	0.659	1.00
83_T	145_P	0.659	1.00
153_R	274_D	0.657	1.00
217_S	244_S	0.657	1.00
52_S	56_L	0.656	1.00
226_V	229_V	0.655	1.00
151_V	155_L	0.654	1.00
231_E	251_I	0.653	1.00
21_P	123_K	0.653	1.00
152_Y	291_T	0.652	1.00
247_S	273_K	0.650	1.00
238_L	251_I	0.649	1.00
34_K	63_V	0.649	1.00
228_I	252_I	0.646	1.00
180_I	206_Y	0.642	1.00
221_K	225_D	0.642	1.00
308_V	332_I	0.641	1.00
28_A	66_V	0.637	1.00
294_L	298_G	0.635	1.00
147_V	178_H	0.632	1.00
43_L	48_F	0.632	1.00
184_K	190_V	0.630	1.00
152_Y	287_D	0.629	1.00
202_I	206_Y	0.629	1.00
23_P	70_G	0.629	1.00
80_D	134_E	0.623	1.00
224_G	246_R	0.623	1.00
63_V	132_V	0.623	1.00
220_A	223_I	0.622	1.00
205_K	303_V	0.620	1.00
269_Y	272_L	0.618	1.00
53_K	56_L	0.616	1.00
130_V	292_L	0.616	1.00
182_V	186_L	0.616	1.00
226_V	244_S	0.615	1.00
151_V	175_V	0.613	1.00
8_A	14_R	0.613	1.00
145_P	148_A	0.609	1.00
319_L	326_R	0.609	1.00
30_I	129_L	0.608	1.00
216_F	219_E	0.608	1.00
63_V	81_R	0.606	1.00
200_A	203_V	0.605	1.00
306_S	330_I	0.605	1.00
194_T	199_K	0.604	1.00
228_I	250_K	0.603	1.00
260_S	266_R	0.603	1.00
143_I	331_L	0.602	1.00
30_I	84_S	0.602	1.00
162_K	187_G	0.601	1.00
275_I	279_G	0.600	1.00
274_D	284_N	0.600	1.00
37_L	118_F	0.599	1.00
209_Y	219_E	0.599	1.00
203_V	210_V	0.595	1.00
40_R	44_Q	0.595	1.00
60_H	146_C	0.595	1.00
154_G	252_I	0.594	1.00
85_M	130_V	0.592	1.00
81_R	135_S	0.592	1.00
144_V	291_T	0.591	1.00
158_A	250_K	0.589	1.00
179_A	254_I	0.588	1.00
42_L	46_K	0.587	1.00
84_S	129_L	0.585	1.00
194_T	213_G	0.584	1.00
162_K	186_L	0.584	1.00
156_K	159_G	0.578	1.00
35_A	332_I	0.576	1.00
146_C	150_M	0.573	1.00
305_G	328_G	0.572	1.00
317_L	321_N	0.570	1.00
196_G	200_A	0.569	1.00
184_K	207_A	0.568	1.00
236_Y	239_E	0.568	1.00
165_I	209_Y	0.567	1.00
38_C	146_C	0.566	1.00
76_F	126_A	0.564	1.00
69_V	80_D	0.564	1.00
75_D	78_K	0.563	1.00
239_E	264_N	0.563	1.00
59_G	118_F	0.562	1.00
177_I	206_Y	0.559	1.00
287_D	290_K	0.558	1.00
165_I	225_D	0.558	1.00
125_K	128_S	0.556	1.00
237_T	241_S	0.556	1.00
21_P	121_K	0.555	1.00
11_Q	318_D	0.553	1.00
74_K	77_K	0.553	1.00
166_V	228_I	0.552	1.00
38_C	147_V	0.552	1.00
167_L	229_V	0.552	1.00
39_Y	43_L	0.549	1.00
180_I	203_V	0.549	1.00
19_P	22_K	0.547	1.00
288_I	292_L	0.547	1.00
13_Y	317_L	0.546	1.00
63_V	141_A	0.545	1.00
153_R	157_K	0.545	1.00
147_V	329_K	0.542	1.00
216_F	220_A	0.541	1.00
168_V	180_I	0.539	1.00
21_P	27_E	0.539	1.00
281_I	284_N	0.538	1.00
155_L	182_V	0.538	1.00
306_S	312_N	0.535	1.00
229_V	244_S	0.534	1.00
44_Q	49_Y	0.533	1.00
61_E	146_C	0.533	1.00
235_P	239_E	0.532	1.00
178_H	182_V	0.531	1.00
37_L	332_I	0.529	1.00
306_S	327_Y	0.529	1.00
272_L	281_I	0.528	1.00
152_Y	186_L	0.527	1.00
316_A	332_I	0.526	1.00
308_V	315_K	0.526	1.00
57_I	116_G	0.524	1.00
156_K	286_N	0.524	1.00
178_H	300_I	0.523	1.00
193_V	211_I	0.521	1.00
40_R	43_L	0.520	1.00
260_S	263_F	0.520	1.00
220_A	244_S	0.520	1.00
197_E	204_S	0.519	1.00
225_D	246_R	0.518	1.00
154_G	280_H	0.517	1.00
32_V	84_S	0.516	1.00
75_D	131_K	0.512	1.00
84_S	117_F	0.512	1.00
152_Y	182_V	0.511	1.00
238_L	253_Q	0.511	1.00
69_V	76_F	0.510	1.00
199_K	324_K	0.506	1.00
289_I	292_L	0.505	1.00
36_A	142_V	0.505	1.00
211_I	219_E	0.503	1.00
231_E	255_G	0.503	1.00
9_H	12_G	0.503	1.00
155_L	179_A	0.502	1.00
305_G	327_Y	0.501	1.00
239_E	266_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gi2A	2	0.994	100	0.156	Contact Map
1rjwA	4	0.9851	100	0.164	Contact Map
2eihA	4	0.9911	100	0.169	Contact Map
1h2bA	4	0.9762	100	0.17	Contact Map
2dq4A	4	0.9792	100	0.171	Contact Map
4jbgA	4	0.9702	100	0.173	Contact Map
3ukoA	4	0.9881	100	0.174	Contact Map
2h6eA	4	0.9107	100	0.176	Contact Map
1cdoA	2	0.9792	100	0.176	Contact Map
4gkvA	4	0.9792	100	0.176	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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