GREMLIN Database
Q97VW0 - Alcohol dehydrogenase (Zn containing) (Adh-8)
UniProt: Q97VW0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 336 (299)
Sequences: 52778 (36249)
Seq/√Len: 2096.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_N138_D3.0581.00
31_K67_E2.9891.00
33_N65_T2.8941.00
312_N315_K2.7801.00
165_I189_K2.6641.00
7_P16_E2.5931.00
29_I67_E2.5271.00
77_K80_D2.4871.00
81_R132_V2.3991.00
80_D131_K2.3941.00
171_A192_G2.3571.00
28_A129_L2.3241.00
20_D121_K2.3021.00
7_P14_R2.2861.00
137_S140_G2.2761.00
308_V319_L2.2761.00
161_K164_E2.2641.00
184_K208_D2.2361.00
31_K121_K2.2101.00
31_K65_T2.1961.00
166_V183_A2.1691.00
139_E307_E2.1361.00
306_S319_L2.1091.00
219_E222_K2.0881.00
5_I16_E2.0821.00
189_K209_Y2.0751.00
24_G27_E2.0691.00
62_V84_S2.0631.00
200_A204_S2.0431.00
25_K71_E2.0331.00
25_K72_D1.9981.00
75_D126_A1.9941.00
29_I123_K1.9731.00
309_S312_N1.9691.00
135_S296_K1.9611.00
67_E121_K1.9471.00
201_K205_K1.9461.00
62_V117_F1.9141.00
46_K321_N1.9081.00
293_N297_E1.8951.00
26_D72_D1.8881.00
201_K204_S1.8561.00
318_D322_D1.8491.00
180_I207_A1.8381.00
200_A210_V1.8361.00
63_V138_D1.8081.00
81_R138_D1.8061.00
250_K276_S1.7951.00
185_A299_K1.7891.00
167_L193_V1.7621.00
319_L324_K1.7231.00
227_S246_R1.7121.00
132_V138_D1.6771.00
250_K278_M1.6751.00
197_E201_K1.6721.00
167_L226_V1.6691.00
191_I226_V1.6541.00
315_K318_D1.6271.00
315_K319_L1.6041.00
202_I205_K1.6041.00
148_A178_H1.6011.00
194_T200_A1.6011.00
132_V141_A1.5871.00
29_I121_K1.5781.00
4_V313_F1.5761.00
308_V316_A1.5651.00
305_G319_L1.5621.00
22_K68_E1.5551.00
65_T81_R1.5491.00
209_Y223_I1.5091.00
169_T241_S1.5041.00
245_L251_I1.5011.00
68_E78_K1.4991.00
195_S213_G1.4991.00
140_G301_K1.4971.00
314_G318_D1.4791.00
69_V78_K1.4741.00
229_V245_L1.4681.00
158_A228_I1.4651.00
29_I68_E1.4651.00
245_L275_I1.4571.00
26_D125_K1.4541.00
27_E125_K1.4411.00
76_F131_K1.4351.00
76_F80_D1.4301.00
32_V62_V1.4231.00
189_K208_D1.4161.00
118_F317_L1.4051.00
27_E123_K1.4031.00
245_L249_G1.3911.00
70_G73_V1.3801.00
164_E250_K1.3711.00
197_E212_V1.3631.00
81_R134_E1.3611.00
3_A18_V1.3571.00
34_K139_E1.3491.00
229_V241_S1.3391.00
212_V215_K1.3381.00
293_N296_K1.3281.00
185_A294_L1.3251.00
65_T138_D1.3181.00
23_P123_K1.3161.00
165_I191_I1.3141.00
23_P29_I1.3011.00
28_A76_F1.3001.00
4_V15_I1.2951.00
197_E215_K1.2851.00
66_V76_F1.2751.00
169_T193_V1.2711.00
179_A230_I1.2701.00
45_I317_L1.2501.00
33_N81_R1.2481.00
219_E223_I1.2281.00
180_I192_G1.2151.00
156_K287_D1.2071.00
32_V122_A1.2071.00
218_E222_K1.1891.00
20_D29_I1.1841.00
200_A212_V1.1691.00
76_F129_L1.1681.00
144_V295_V1.1661.00
165_I227_S1.1641.00
26_D126_A1.1511.00
5_I18_V1.1221.00
294_L299_K1.1151.00
160_I188_A1.1131.00
164_E227_S1.1051.00
243_K269_Y1.0961.00
217_S221_K1.0851.00
197_E200_A1.0771.00
290_K293_N1.0741.00
204_S210_V1.0721.00
202_I327_Y1.0701.00
156_K290_K1.0701.00
8_A12_G1.0651.00
124_V129_L1.0531.00
183_A188_A1.0431.00
153_R287_D1.0401.00
15_I311_E1.0391.00
151_V179_A1.0351.00
30_I82_V1.0341.00
35_A118_F1.0321.00
195_S214_E1.0311.00
136_V141_A1.0301.00
313_F332_I1.0281.00
217_S243_K1.0281.00
191_I209_Y1.0271.00
45_I321_N1.0241.00
160_I164_E1.0161.00
34_K138_D1.0131.00
158_A252_I1.0061.00
73_V126_A0.9981.00
4_V310_L0.9961.00
30_I64_G0.9961.00
233_V237_T0.9921.00
37_L316_A0.9911.00
157_K276_S0.9891.00
67_E78_K0.9861.00
318_D321_N0.9841.00
204_S209_Y0.9811.00
154_G254_I0.9731.00
9_H54_Y0.9711.00
205_K302_P0.9631.00
240_E243_K0.9621.00
152_Y290_K0.9561.00
217_S240_E0.9511.00
289_I293_N0.9511.00
23_P27_E0.9501.00
290_K294_L0.9361.00
192_G207_A0.9341.00
308_V312_N0.9311.00
319_L330_I0.9291.00
215_K219_E0.9281.00
171_A194_T0.9271.00
154_G230_I0.9261.00
239_E243_K0.9231.00
192_G203_V0.9221.00
269_Y273_K0.9191.00
171_A180_I0.9121.00
83_T292_L0.9121.00
74_K126_A0.9121.00
171_A203_V0.9111.00
118_F313_F0.9111.00
248_G274_D0.9101.00
207_A210_V0.9071.00
157_K278_M0.9031.00
151_V182_V0.9021.00
42_L320_L0.9011.00
194_T210_V0.8981.00
164_E228_I0.8971.00
56_L115_D0.8961.00
34_K331_L0.8931.00
231_E234_G0.8931.00
7_P12_G0.8921.00
177_I202_I0.8791.00
193_V213_G0.8791.00
69_V77_K0.8741.00
180_I190_V0.8731.00
198_S201_K0.8711.00
199_K327_Y0.8701.00
33_N63_V0.8691.00
4_V13_Y0.8611.00
167_L244_S0.8551.00
196_G199_K0.8551.00
35_A117_F0.8551.00
169_T229_V0.8521.00
20_D68_E0.8511.00
38_C61_E0.8491.00
191_I211_I0.8491.00
5_I57_I0.8471.00
3_A57_I0.8461.00
286_N290_K0.8431.00
31_K120_E0.8411.00
236_Y240_E0.8371.00
8_A11_Q0.8351.00
196_G212_V0.8341.00
168_V183_A0.8341.00
69_V73_V0.8311.00
159_G250_K0.8301.00
306_S315_K0.8241.00
20_D67_E0.8161.00
183_A190_V0.8161.00
149_A287_D0.8151.00
195_S200_A0.8061.00
130_V289_I0.8031.00
62_V122_A0.7991.00
117_F122_A0.7931.00
286_N289_I0.7931.00
260_S264_N0.7901.00
38_C60_H0.7871.00
28_A126_A0.7841.00
168_V179_A0.7841.00
22_K29_I0.7821.00
166_V188_A0.7801.00
229_V251_I0.7801.00
18_V115_D0.7801.00
220_A226_V0.7731.00
182_V291_T0.7721.00
77_K131_K0.7701.00
218_E221_K0.7691.00
84_S124_V0.7671.00
190_V208_D0.7631.00
232_N254_I0.7621.00
241_S251_I0.7611.00
294_L297_E0.7611.00
37_L320_L0.7601.00
36_A61_E0.7601.00
133_P296_K0.7561.00
270_I277_L0.7561.00
239_E269_Y0.7551.00
169_T237_T0.7541.00
18_V57_I0.7521.00
24_G123_K0.7481.00
38_C41_D0.7481.00
304_I307_E0.7471.00
308_V330_I0.7471.00
165_I224_G0.7441.00
118_F332_I0.7411.00
151_V178_H0.7361.00
266_R269_Y0.7351.00
203_V207_A0.7341.00
216_F240_E0.7331.00
134_E296_K0.7311.00
165_I226_V0.7311.00
186_L290_K0.7291.00
63_V142_V0.7261.00
40_R60_H0.7231.00
182_V294_L0.7221.00
155_L183_A0.7221.00
82_V129_L0.7201.00
319_L322_D0.7191.00
159_G276_S0.7111.00
83_T132_V0.7041.00
154_G179_A0.7021.00
194_T203_V0.7011.00
15_I310_L0.6981.00
177_I303_V0.6981.00
202_I303_V0.6961.00
4_V314_G0.6961.00
270_I275_I0.6941.00
136_V295_V0.6931.00
34_K307_E0.6921.00
26_D70_G0.6921.00
292_L296_K0.6911.00
159_G278_M0.6901.00
326_R330_I0.6881.00
26_D127_S0.6871.00
168_V192_G0.6861.00
204_S207_A0.6861.00
152_Y294_L0.6861.00
181_Q301_K0.6851.00
26_D71_E0.6831.00
253_Q277_L0.6831.00
320_L330_I0.6801.00
42_L321_N0.6761.00
188_A228_I0.6761.00
23_P68_E0.6751.00
160_I228_I0.6751.00
32_V35_A0.6731.00
191_I220_A0.6721.00
181_Q206_Y0.6711.00
270_I279_G0.6691.00
148_A291_T0.6681.00
191_I223_I0.6641.00
130_V288_I0.6621.00
156_K186_L0.6591.00
83_T145_P0.6591.00
153_R274_D0.6571.00
217_S244_S0.6571.00
52_S56_L0.6561.00
226_V229_V0.6551.00
151_V155_L0.6541.00
231_E251_I0.6531.00
21_P123_K0.6531.00
152_Y291_T0.6521.00
247_S273_K0.6501.00
238_L251_I0.6491.00
34_K63_V0.6491.00
228_I252_I0.6461.00
180_I206_Y0.6421.00
221_K225_D0.6421.00
308_V332_I0.6411.00
28_A66_V0.6371.00
294_L298_G0.6351.00
147_V178_H0.6321.00
43_L48_F0.6321.00
184_K190_V0.6301.00
152_Y287_D0.6291.00
202_I206_Y0.6291.00
23_P70_G0.6291.00
80_D134_E0.6231.00
224_G246_R0.6231.00
63_V132_V0.6231.00
220_A223_I0.6221.00
205_K303_V0.6201.00
269_Y272_L0.6181.00
53_K56_L0.6161.00
130_V292_L0.6161.00
182_V186_L0.6161.00
226_V244_S0.6151.00
151_V175_V0.6131.00
8_A14_R0.6131.00
145_P148_A0.6091.00
319_L326_R0.6091.00
30_I129_L0.6081.00
216_F219_E0.6081.00
63_V81_R0.6061.00
200_A203_V0.6051.00
306_S330_I0.6051.00
194_T199_K0.6041.00
228_I250_K0.6031.00
260_S266_R0.6031.00
143_I331_L0.6021.00
30_I84_S0.6021.00
162_K187_G0.6011.00
275_I279_G0.6001.00
274_D284_N0.6001.00
37_L118_F0.5991.00
209_Y219_E0.5991.00
203_V210_V0.5951.00
40_R44_Q0.5951.00
60_H146_C0.5951.00
154_G252_I0.5941.00
85_M130_V0.5921.00
81_R135_S0.5921.00
144_V291_T0.5911.00
158_A250_K0.5891.00
179_A254_I0.5881.00
42_L46_K0.5871.00
84_S129_L0.5851.00
194_T213_G0.5841.00
162_K186_L0.5841.00
156_K159_G0.5781.00
35_A332_I0.5761.00
146_C150_M0.5731.00
305_G328_G0.5721.00
317_L321_N0.5701.00
196_G200_A0.5691.00
184_K207_A0.5681.00
236_Y239_E0.5681.00
165_I209_Y0.5671.00
38_C146_C0.5661.00
76_F126_A0.5641.00
69_V80_D0.5641.00
75_D78_K0.5631.00
239_E264_N0.5631.00
59_G118_F0.5621.00
177_I206_Y0.5591.00
287_D290_K0.5581.00
165_I225_D0.5581.00
125_K128_S0.5561.00
237_T241_S0.5561.00
21_P121_K0.5551.00
11_Q318_D0.5531.00
74_K77_K0.5531.00
166_V228_I0.5521.00
38_C147_V0.5521.00
167_L229_V0.5521.00
39_Y43_L0.5491.00
180_I203_V0.5491.00
19_P22_K0.5471.00
288_I292_L0.5471.00
13_Y317_L0.5461.00
63_V141_A0.5451.00
153_R157_K0.5451.00
147_V329_K0.5421.00
216_F220_A0.5411.00
168_V180_I0.5391.00
21_P27_E0.5391.00
281_I284_N0.5381.00
155_L182_V0.5381.00
306_S312_N0.5351.00
229_V244_S0.5341.00
44_Q49_Y0.5331.00
61_E146_C0.5331.00
235_P239_E0.5321.00
178_H182_V0.5311.00
37_L332_I0.5291.00
306_S327_Y0.5291.00
272_L281_I0.5281.00
152_Y186_L0.5271.00
316_A332_I0.5261.00
308_V315_K0.5261.00
57_I116_G0.5241.00
156_K286_N0.5241.00
178_H300_I0.5231.00
193_V211_I0.5211.00
40_R43_L0.5201.00
260_S263_F0.5201.00
220_A244_S0.5201.00
197_E204_S0.5191.00
225_D246_R0.5181.00
154_G280_H0.5171.00
32_V84_S0.5161.00
75_D131_K0.5121.00
84_S117_F0.5121.00
152_Y182_V0.5111.00
238_L253_Q0.5111.00
69_V76_F0.5101.00
199_K324_K0.5061.00
289_I292_L0.5051.00
36_A142_V0.5051.00
211_I219_E0.5031.00
231_E255_G0.5031.00
9_H12_G0.5031.00
155_L179_A0.5021.00
305_G327_Y0.5011.00
239_E266_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gi2A 2 0.994 100 0.156 Contact Map
1rjwA 4 0.9851 100 0.164 Contact Map
2eihA 4 0.9911 100 0.169 Contact Map
1h2bA 4 0.9762 100 0.17 Contact Map
2dq4A 4 0.9792 100 0.171 Contact Map
4jbgA 4 0.9702 100 0.173 Contact Map
3ukoA 4 0.9881 100 0.174 Contact Map
2h6eA 4 0.9107 100 0.176 Contact Map
1cdoA 2 0.9792 100 0.176 Contact Map
4gkvA 4 0.9792 100 0.176 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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