GREMLIN Database
Q97VV9 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-5)
UniProt: Q97VV9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 395 (375)
Sequences: 15230 (8312)
Seq/√Len: 429.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_D264_K3.4061.00
184_R188_L3.3801.00
266_A270_Y3.3011.00
177_E331_K3.2991.00
115_A118_V2.9601.00
183_L228_I2.8361.00
103_V361_V2.8091.00
43_R46_E2.7541.00
191_K195_E2.6821.00
3_E265_N2.6621.00
266_A269_K2.6421.00
264_K268_K2.6411.00
184_R187_Q2.6241.00
178_M243_T2.6031.00
194_Q224_P2.5441.00
364_L376_G2.5331.00
10_Y362_G2.3641.00
41_I119_L2.3441.00
6_Y267_L2.3401.00
110_I261_L2.3391.00
302_A306_A2.3351.00
302_A391_V2.3051.00
11_A47_K2.2781.00
44_L260_L2.1941.00
199_K217_N2.1941.00
174_K177_E2.1061.00
117_I262_M2.1031.00
206_E215_V2.0991.00
276_A365_A2.0691.00
193_I222_V2.0551.00
106_G118_V2.0501.00
280_S306_A2.0111.00
315_L342_K2.0051.00
51_K54_E1.9831.00
368_L373_K1.9711.00
37_A60_T1.9661.00
8_V262_M1.9621.00
110_I263_S1.9411.00
39_M205_I1.9321.00
277_K393_E1.9181.00
221_S251_P1.9091.00
4_D277_K1.8921.00
308_L375_Y1.8861.00
275_M369_I1.8811.00
176_E180_R1.8511.00
184_R337_E1.8161.00
190_W222_V1.7851.00
257_S358_A1.7781.00
54_E270_Y1.7651.00
190_W194_Q1.7631.00
27_P216_V1.7531.00
330_I337_E1.7511.00
167_L173_I1.7481.00
231_L247_G1.7421.00
280_S302_A1.7391.00
262_M266_A1.7151.00
116_D263_S1.6981.00
199_K218_V1.6951.00
193_I202_I1.6831.00
314_D373_K1.6721.00
262_M267_L1.6601.00
170_E290_V1.6551.00
300_K304_E1.6471.00
367_Q371_E1.6401.00
193_I218_V1.6381.00
330_I340_V1.6361.00
343_K367_Q1.6211.00
116_D266_A1.6171.00
308_L313_I1.6091.00
310_T316_W1.6061.00
197_Y343_K1.6031.00
299_S379_T1.5961.00
108_M114_M1.5921.00
39_M203_L1.5861.00
109_E115_A1.5831.00
90_M105_I1.5811.00
60_T121_G1.5811.00
200_D369_I1.5731.00
161_G238_F1.5701.00
230_K233_Q1.5671.00
183_L187_Q1.5651.00
313_I391_V1.5601.00
313_I316_W1.5521.00
263_S266_A1.5511.00
35_E80_A1.5471.00
43_R203_L1.5431.00
259_V358_A1.5361.00
297_P300_K1.5291.00
180_R228_I1.5001.00
315_L367_Q1.4871.00
106_G261_L1.4841.00
41_I77_E1.4821.00
125_K128_R1.4721.00
44_L48_N1.4641.00
37_A77_E1.4581.00
6_Y277_K1.4581.00
42_N46_E1.4561.00
180_R184_R1.4461.00
336_D339_T1.4441.00
117_I266_A1.4371.00
308_L391_V1.4261.00
367_Q370_I1.4191.00
28_F216_V1.4191.00
197_Y367_Q1.4161.00
361_V392_L1.4071.00
187_Q191_K1.4061.00
187_Q225_D1.4061.00
40_V258_Y1.4061.00
279_R393_E1.3951.00
40_V256_A1.3851.00
132_F147_S1.3781.00
316_W377_V1.3571.00
374_D393_E1.3531.00
104_S390_I1.3521.00
303_L310_T1.3441.00
3_E263_S1.3401.00
282_G301_K1.3341.00
43_R47_K1.3261.00
85_Y287_P1.3061.00
177_E180_R1.3031.00
9_D44_L1.2901.00
301_K304_E1.2871.00
190_W225_D1.2841.00
73_G123_V1.2801.00
15_F355_A1.2791.00
282_G302_A1.2691.00
31_I39_M1.2581.00
313_I375_Y1.2541.00
56_D115_A1.2521.00
377_V391_V1.2491.00
175_R245_T1.2421.00
265_N269_K1.2381.00
5_V261_L1.2331.00
11_A203_L1.2281.00
62_C65_Q1.2271.00
104_S281_F1.2221.00
119_L260_L1.2141.00
342_K367_Q1.2121.00
38_G80_A1.2101.00
200_D370_I1.2101.00
197_Y370_I1.2071.00
362_G366_R1.2031.00
55_I117_I1.2031.00
103_V259_V1.1991.00
298_A389_A1.1931.00
365_A369_I1.1861.00
300_K332_Q1.1851.00
60_T258_Y1.1831.00
299_S377_V1.1811.00
97_A388_G1.1671.00
296_V300_K1.1621.00
173_I178_M1.1611.00
165_E242_G1.1491.00
284_A297_P1.1451.00
15_F349_I1.1311.00
201_E363_T1.1281.00
309_S312_K1.1171.00
6_Y264_K1.1151.00
54_E266_A1.1131.00
306_A391_V1.1061.00
39_M43_R1.1031.00
286_V293_K1.1021.00
9_D48_N1.1021.00
228_I232_G1.1001.00
161_G237_A1.0951.00
56_D116_D1.0871.00
59_I118_V1.0851.00
181_W326_V1.0801.00
10_Y366_R1.0781.00
61_G98_S1.0781.00
101_T105_I1.0751.00
106_G120_A1.0701.00
166_K170_E1.0691.00
100_L361_V1.0661.00
200_D366_R1.0641.00
293_K296_V1.0621.00
97_A382_V1.0591.00
173_I327_L1.0581.00
114_M305_K1.0561.00
6_Y262_M1.0521.00
290_V293_K1.0461.00
41_I83_L1.0411.00
190_W224_P1.0371.00
111_S114_M1.0351.00
181_W327_L1.0301.00
280_S305_K1.0261.00
315_L371_E1.0251.00
184_R338_S1.0211.00
58_I78_I1.0211.00
278_I390_I1.0161.00
314_D368_L1.0141.00
342_K371_E1.0131.00
19_S135_P1.0111.00
314_D339_T1.0081.00
103_V261_L1.0081.00
14_A216_V1.0071.00
284_A301_K1.0061.00
108_M112_T1.0041.00
7_L392_L0.9991.00
11_A43_R0.9961.00
3_E116_D0.9921.00
226_T231_L0.9921.00
375_Y393_E0.9921.00
171_A293_K0.9821.00
264_K277_K0.9821.00
9_D47_K0.9781.00
279_R375_Y0.9771.00
10_Y365_A0.9681.00
234_L247_G0.9661.00
170_E289_A0.9621.00
54_E269_K0.9591.00
275_M365_A0.9541.00
38_G42_N0.9511.00
32_R35_E0.9491.00
343_K370_I0.9481.00
359_R363_T0.9471.00
280_S391_V0.9461.00
310_T313_I0.9451.00
183_L231_L0.9451.00
45_I83_L0.9401.00
187_Q190_W0.9351.00
165_E169_E0.9341.00
40_V43_R0.9341.00
227_S230_K0.9331.00
379_T382_V0.9301.00
335_L340_V0.9271.00
193_I199_K0.9261.00
83_L87_I0.9241.00
316_W335_L0.9161.00
315_L364_L0.9141.00
257_S355_A0.9091.00
45_I50_I0.9061.00
171_A332_Q0.9021.00
299_S333_L0.8981.00
4_D111_S0.8951.00
364_L378_A0.8951.00
107_A278_I0.8941.00
183_L225_D0.8941.00
5_V263_S0.8901.00
301_K305_K0.8891.00
8_V272_L0.8861.00
59_I102_T0.8851.00
257_S362_G0.8851.00
176_E232_G0.8841.00
375_Y391_V0.8831.00
16_T220_Q0.8821.00
13_T40_V0.8801.00
234_L245_T0.8801.00
167_L293_K0.8741.00
79_F85_Y0.8721.00
318_I379_T0.8691.00
313_I377_V0.8671.00
168_A324_V0.8651.00
15_F253_N0.8611.00
360_L378_A0.8601.00
17_R221_S0.8591.00
167_L328_Y0.8591.00
330_I335_L0.8571.00
13_T36_L0.8541.00
293_K328_Y0.8521.00
293_K332_Q0.8501.00
59_I90_M0.8481.00
262_M272_L0.8461.00
44_L119_L0.8441.00
365_A392_L0.8411.00
59_I106_G0.8411.00
10_Y259_V0.8411.00
189_A222_V0.8361.00
14_A39_M0.8361.00
166_K169_E0.8361.00
193_I224_P0.8331.00
54_E117_I0.8251.00
5_V107_A0.8241.00
94_R101_T0.8231.00
107_A111_S0.8191.00
13_T39_M0.8181.00
195_E370_I0.8171.00
235_P246_A0.8171.00
278_I281_F0.8171.00
179_D248_N0.8141.00
273_T369_I0.8141.00
120_A259_V0.8131.00
361_V390_I0.8121.00
15_F359_R0.8081.00
326_V330_I0.8051.00
55_I119_L0.8051.00
264_K267_L0.8001.00
149_Y159_V0.7981.00
296_V332_Q0.7981.00
343_K371_E0.7971.00
286_V297_P0.7941.00
194_Q218_V0.7911.00
346_A356_T0.7891.00
31_I35_E0.7891.00
45_I55_I0.7851.00
323_A347_I0.7831.00
133_D137_I0.7831.00
191_K194_Q0.7831.00
176_E228_I0.7821.00
265_N268_K0.7821.00
191_K197_Y0.7801.00
102_T358_A0.7771.00
382_V388_G0.7751.00
127_S254_S0.7731.00
299_S389_A0.7731.00
300_K333_L0.7731.00
188_L191_K0.7721.00
382_V386_Q0.7721.00
381_C385_G0.7701.00
33_P123_V0.7631.00
56_D301_K0.7611.00
114_M281_F0.7601.00
226_T230_K0.7591.00
189_A193_I0.7561.00
105_I108_M0.7561.00
68_E128_R0.7551.00
58_I87_I0.7541.00
177_E327_L0.7531.00
62_C68_E0.7531.00
188_L337_E0.7521.00
57_E109_E0.7441.00
40_V44_L0.7441.00
308_L312_K0.7411.00
119_L258_Y0.7401.00
137_I142_K0.7391.00
248_N323_A0.7361.00
34_E68_E0.7361.00
311_R339_T0.7361.00
60_T74_G0.7351.00
44_L258_Y0.7351.00
164_A324_V0.7341.00
380_L383_G0.7341.00
152_Y157_G0.7321.00
183_L226_T0.7271.00
378_A382_V0.7231.00
13_T205_I0.7201.00
5_V111_S0.7181.00
149_Y152_Y0.7161.00
145_T150_I0.7131.00
141_T145_T0.7111.00
27_P220_Q0.7101.00
59_I105_I0.7081.00
37_A121_G0.7061.00
108_M111_S0.7031.00
109_E114_M0.7031.00
104_S388_G0.7021.00
105_I109_E0.7021.00
311_R334_E0.7021.00
275_M366_R0.7001.00
45_I52_A0.6971.00
39_M42_N0.6941.00
310_T335_L0.6941.00
236_P242_G0.6901.00
279_R306_A0.6891.00
318_I329_A0.6871.00
183_L230_K0.6861.00
299_S318_I0.6841.00
368_L376_G0.6831.00
83_L119_L0.6811.00
32_R128_R0.6801.00
62_C73_G0.6801.00
229_E233_Q0.6791.00
11_A40_V0.6791.00
42_N52_A0.6761.00
259_V362_G0.6751.00
303_L308_L0.6731.00
3_E111_S0.6731.00
226_T247_G0.6731.00
56_D118_V0.6731.00
94_R283_F0.6711.00
100_L390_I0.6701.00
286_V294_G0.6701.00
35_E38_G0.6661.00
38_G81_A0.6651.00
60_T77_E0.6641.00
328_Y332_Q0.6621.00
52_A84_P0.6611.00
158_Y162_L0.6590.99
5_V110_I0.6590.99
221_S253_N0.6580.99
163_T291_M0.6570.99
159_V162_L0.6570.99
183_L227_S0.6560.99
117_I270_Y0.6540.99
162_L166_K0.6540.99
186_H221_S0.6530.99
55_I83_L0.6520.99
283_F388_G0.6510.99
63_A353_L0.6510.99
57_E283_F0.6510.99
109_E118_V0.6500.99
9_D275_M0.6490.99
186_H190_W0.6490.99
186_H222_V0.6490.99
382_V387_G0.6480.99
116_D305_K0.6470.99
92_V105_I0.6460.99
11_A44_L0.6450.99
196_G199_K0.6440.99
139_V148_K0.6430.99
7_L261_L0.6430.99
302_A377_V0.6430.99
42_N82_R0.6420.99
173_I177_E0.6380.99
78_I89_T0.6380.99
106_G115_A0.6360.99
373_K376_G0.6350.99
299_S310_T0.6340.99
356_T360_L0.6330.99
244_I249_S0.6330.99
261_L278_I0.6320.99
100_L378_A0.6310.99
45_I49_G0.6280.99
45_I48_N0.6260.99
173_I331_K0.6250.99
326_V340_V0.6250.99
7_L365_A0.6240.99
369_I372_G0.6220.99
88_P283_F0.6220.99
274_P277_K0.6220.99
314_D375_Y0.6220.99
77_E81_A0.6220.99
179_D228_I0.6220.99
197_Y371_E0.6220.99
381_C384_G0.6200.99
278_I392_L0.6200.99
282_G305_K0.6190.99
167_L171_A0.6180.99
189_A348_A0.6180.99
116_D269_K0.6170.99
190_W223_R0.6160.99
90_M101_T0.6150.99
378_A381_C0.6150.99
36_L205_I0.6120.99
72_F386_Q0.6120.99
6_Y263_S0.6110.99
53_E86_N0.6110.99
237_A246_A0.6100.99
41_I81_A0.6100.99
287_P290_V0.6100.99
148_K151_E0.6090.99
57_E94_R0.6090.99
31_I128_R0.6080.99
279_R308_L0.6070.99
77_E123_V0.6030.99
164_A244_I0.6010.99
133_D138_E0.6010.99
139_V149_Y0.6010.99
8_V267_L0.6000.99
126_L353_L0.6000.99
103_V120_A0.5990.99
48_N260_L0.5980.99
34_E80_A0.5970.99
164_A168_A0.5970.99
41_I45_I0.5960.99
186_H347_I0.5940.99
186_H225_D0.5940.99
372_G375_Y0.5930.99
204_P215_V0.5920.99
169_E241_N0.5880.99
262_M270_Y0.5880.99
321_A351_H0.5880.99
361_V378_A0.5870.99
316_W379_T0.5850.99
349_I359_R0.5850.99
204_P217_N0.5850.99
201_E366_R0.5840.99
30_N128_R0.5820.99
182_S186_H0.5820.99
6_Y266_A0.5810.99
50_I260_L0.5800.99
31_I125_K0.5790.99
153_D156_T0.5790.99
158_Y289_A0.5770.99
41_I258_Y0.5770.99
179_D232_G0.5770.99
304_E309_S0.5760.99
101_T104_S0.5750.99
171_A328_Y0.5750.99
327_L331_K0.5750.99
103_V358_A0.5750.99
379_T385_G0.5740.99
138_E141_T0.5740.99
297_P301_K0.5720.99
121_G258_Y0.5710.99
8_V266_A0.5690.99
37_A123_V0.5670.98
78_I83_L0.5660.98
379_T383_G0.5650.98
303_L306_A0.5650.98
65_Q91_A0.5650.98
229_E232_G0.5620.98
271_G274_P0.5610.98
300_K334_E0.5610.98
218_V224_P0.5600.98
238_F242_G0.5580.98
314_D374_D0.5580.98
42_N81_A0.5580.98
102_T120_A0.5570.98
325_V329_A0.5570.98
158_Y166_K0.5570.98
100_L388_G0.5570.98
57_E115_A0.5560.98
228_I231_L0.5550.98
189_A349_I0.5550.98
111_S281_F0.5540.98
225_D230_K0.5540.98
41_I58_I0.5540.98
299_S329_A0.5530.98
63_A95_Q0.5530.98
14_A202_I0.5500.98
299_S303_L0.5490.98
101_T283_F0.5470.98
64_L129_T0.5470.98
182_S323_A0.5430.98
129_T147_S0.5410.98
330_I336_D0.5400.98
39_M206_E0.5400.98
318_I326_V0.5390.98
171_A290_V0.5390.98
180_R337_E0.5380.98
59_I92_V0.5380.98
302_A313_I0.5360.98
182_S231_L0.5350.98
324_V328_Y0.5350.98
288_P292_G0.5340.98
165_E244_I0.5320.98
355_A358_A0.5310.98
101_T109_E0.5300.98
331_K334_E0.5300.98
198_F349_I0.5260.98
133_D136_H0.5260.98
56_D87_I0.5250.98
289_A292_G0.5240.97
14_A217_N0.5230.97
58_I119_L0.5220.97
109_E112_T0.5210.97
368_L392_L0.5210.97
16_T28_F0.5200.97
168_A243_T0.5200.97
291_M294_G0.5190.97
31_I205_I0.5180.97
81_A84_P0.5180.97
167_L324_V0.5170.97
358_A362_G0.5150.97
379_T384_G0.5140.97
335_L339_T0.5100.97
57_E118_V0.5090.97
316_W339_T0.5080.97
279_R391_V0.5070.97
172_R331_K0.5070.97
288_P291_M0.5070.97
345_G348_A0.5070.97
376_G392_L0.5060.97
116_D265_N0.5050.97
29_Y135_P0.5040.97
6_Y270_Y0.5040.97
282_G306_A0.5030.97
321_A325_V0.5010.97
50_I117_I0.5010.97
267_L270_Y0.5010.97
98_S354_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ulqA 4 0.9797 100 0.27 Contact Map
2wu9A 2 0.9722 100 0.281 Contact Map
4n46A 4 0.9797 100 0.282 Contact Map
2vu1A 4 0.9823 100 0.283 Contact Map
3ss6A 4 0.9823 100 0.286 Contact Map
4e1lA 4 0.962 100 0.287 Contact Map
2ib8A 4 0.9772 100 0.291 Contact Map
4nzsA 4 0.9797 100 0.294 Contact Map
4c2jA 4 0.9696 100 0.297 Contact Map
1afwA 2 0.962 100 0.297 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.