Q97VV8 - SULSO - GREMLIN Contacts

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Q97VV8 - Acyl-CoA dehydrogenase related protein (Acd-like2)

UniProt:	Q97VV8	Sequences: MLLDLNFEISEDLKLILSSLNELLESRWSTKKLRAVMEGNKDYIEEIWKEIIKLDILPYLSTLSLRDNVIINEVIGRKLLPGIVVSSIVASRGIKNKDILNRVYAGEIRIAISDSNLVPSADEADYIIIGNRLIKRSNCTIRTFNSLDSSMKISKVDNIGNHEDIEVNNAEIALSLASQMVGSGEEVVSMSIKYSKERVAFGKPIGSYQAIKHRVVNDAIDVELARSLILEAAENIKYAWIAKDLANKKIPKAILSGIQVHGGIGFTDDLDIHLHLRRALTLSKLYNSKVNISEFLQPI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	299 (281)
Sequences:	31263 (18099)
Seq/√Len:	1079.7

ECOLI - CAIA YDIO AIDB
BACSU - ACDC ACDA FADE YDBM ACDB
HALSA - Q9HS75 Q9HRB3 Q9HRI6 Q9HPT2 Q9HMK7 Q9HQF0
SULSO - Q97VV8 Q97UW6 Q97V73 Q97WQ8 Q97YZ3 Q97U78 Q97XW3 Q97VU6 Q97YZ6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
221_D	252_K	3.513	1.00
112_I	160_G	3.198	1.00
27_R	50_E	3.139	1.00
214_R	256_S	2.989	1.00
64_S	67_D	2.854	1.00
102_R	107_E	2.810	1.00
140_T	159_I	2.740	1.00
21_N	74_V	2.699	1.00
102_R	108_I	2.662	1.00
36_V	40_N	2.486	1.00
114_D	157_D	2.397	1.00
193_K	197_E	2.365	1.00
185_E	226_R	2.197	1.00
89_V	92_R	2.155	1.00
110_I	162_H	2.138	1.00
210_A	213_H	2.122	1.00
22_E	26_S	2.110	1.00
13_L	67_D	2.102	1.00
268_D	273_H	2.018	1.00
114_D	155_K	2.015	1.00
195_S	260_V	1.995	1.00
203_K	207_S	1.961	1.00
50_E	53_K	1.945	1.00
188_V	222_V	1.940	1.00
225_A	246_A	1.900	1.00
199_V	204_P	1.896	1.00
127_I	134_I	1.879	1.00
273_H	277_R	1.831	1.00
251_P	283_S	1.791	1.00
162_H	165_I	1.787	1.00
49_K	53_K	1.775	1.00
252_K	256_S	1.767	1.00
204_P	207_S	1.738	1.00
121_A	154_S	1.733	1.00
264_I	270_L	1.710	1.00
74_V	77_R	1.698	1.00
89_V	93_G	1.698	1.00
190_M	271_D	1.690	1.00
185_E	189_S	1.682	1.00
140_T	157_D	1.657	1.00
15_L	19_S	1.651	1.00
77_R	189_S	1.633	1.00
97_K	101_N	1.627	1.00
98_D	102_R	1.624	1.00
186_E	190_M	1.623	1.00
133_L	136_R	1.619	1.00
136_R	161_N	1.616	1.00
73_E	226_R	1.615	1.00
57_L	60_L	1.583	1.00
122_D	154_S	1.580	1.00
218_D	253_A	1.563	1.00
15_L	18_S	1.556	1.00
89_V	94_I	1.547	1.00
248_K	290_V	1.544	1.00
224_L	245_L	1.528	1.00
200_A	208_Y	1.526	1.00
195_S	211_I	1.526	1.00
14_K	17_L	1.521	1.00
18_S	22_E	1.518	1.00
45_E	49_K	1.510	1.00
13_L	64_S	1.509	1.00
49_K	52_I	1.507	1.00
192_I	196_K	1.487	1.00
190_M	261_H	1.481	1.00
190_M	193_K	1.476	1.00
101_N	105_A	1.472	1.00
203_K	208_Y	1.442	1.00
24_L	78_K	1.440	1.00
102_R	105_A	1.438	1.00
17_L	74_V	1.436	1.00
211_I	260_V	1.430	1.00
184_G	222_V	1.428	1.00
77_R	185_E	1.409	1.00
144_F	147_L	1.407	1.00
13_L	70_I	1.403	1.00
219_A	223_E	1.391	1.00
218_D	256_S	1.382	1.00
50_E	54_L	1.382	1.00
221_D	249_K	1.382	1.00
145_N	268_D	1.372	1.00
188_V	192_I	1.360	1.00
59_Y	62_T	1.359	1.00
223_E	231_E	1.341	1.00
63_L	67_D	1.336	1.00
187_V	254_I	1.330	1.00
11_E	15_L	1.324	1.00
17_L	70_I	1.315	1.00
110_I	160_G	1.310	1.00
250_I	279_A	1.307	1.00
191_S	257_G	1.306	1.00
255_L	280_L	1.305	1.00
251_P	255_L	1.297	1.00
142_R	155_K	1.290	1.00
19_S	54_L	1.284	1.00
112_I	159_I	1.270	1.00
69_V	233_A	1.267	1.00
244_D	290_V	1.264	1.00
21_N	25_E	1.255	1.00
99_I	126_Y	1.255	1.00
184_G	253_A	1.250	1.00
257_G	272_I	1.244	1.00
178_S	229_I	1.235	1.00
195_S	206_G	1.233	1.00
217_N	294_E	1.229	1.00
214_R	291_N	1.228	1.00
225_A	249_K	1.228	1.00
227_S	231_E	1.223	1.00
14_K	18_S	1.212	1.00
31_K	37_M	1.210	1.00
20_L	56_I	1.208	1.00
134_I	139_C	1.200	1.00
96_N	100_L	1.194	1.00
73_E	185_E	1.189	1.00
255_L	283_S	1.188	1.00
251_P	276_L	1.188	1.00
280_L	283_S	1.185	1.00
95_K	99_I	1.163	1.00
35_A	39_G	1.155	1.00
181_V	222_V	1.144	1.00
134_I	141_I	1.141	1.00
249_K	252_K	1.134	1.00
248_K	252_K	1.132	1.00
183_S	250_I	1.123	1.00
73_E	230_L	1.121	1.00
69_V	178_S	1.118	1.00
222_V	253_A	1.117	1.00
137_S	162_H	1.117	1.00
23_L	50_E	1.115	1.00
232_A	242_A	1.112	1.00
217_N	221_D	1.111	1.00
196_K	206_G	1.102	1.00
139_C	161_N	1.100	1.00
212_K	295_F	1.094	1.00
221_D	256_S	1.092	1.00
11_E	14_K	1.087	1.00
106_G	109_R	1.064	1.00
46_E	50_E	1.052	1.00
20_L	71_I	1.049	1.00
258_I	276_L	1.049	1.00
19_S	56_I	1.039	1.00
57_L	104_Y	1.032	1.00
108_I	125_D	1.024	1.00
24_L	75_I	1.017	1.00
79_L	82_G	1.017	1.00
186_E	275_H	1.015	1.00
136_R	139_C	1.013	1.00
129_I	158_N	1.008	1.00
23_L	54_L	1.007	1.00
46_E	49_K	1.006	1.00
116_N	155_K	1.005	1.00
213_H	295_F	0.998	1.00
254_I	279_A	0.994	1.00
90_A	93_G	0.994	1.00
142_R	147_L	0.993	1.00
19_S	22_E	0.992	1.00
138_N	161_N	0.983	1.00
240_W	293_S	0.983	1.00
221_D	245_L	0.965	1.00
139_C	156_V	0.957	1.00
244_D	294_E	0.957	1.00
283_S	290_V	0.955	1.00
217_N	256_S	0.954	1.00
187_V	257_G	0.952	1.00
111_A	130_G	0.951	1.00
172_I	287_N	0.949	1.00
45_E	123_E	0.949	1.00
192_I	215_V	0.948	1.00
219_A	241_I	0.946	1.00
181_V	229_I	0.946	1.00
132_R	136_R	0.943	1.00
195_S	215_V	0.939	1.00
20_L	24_L	0.937	1.00
223_E	226_R	0.931	1.00
220_I	241_I	0.931	1.00
180_M	282_L	0.930	1.00
214_R	217_N	0.929	1.00
220_I	244_D	0.926	1.00
39_G	145_N	0.925	1.00
127_I	139_C	0.925	1.00
49_K	107_E	0.925	1.00
31_K	36_V	0.924	1.00
66_R	230_L	0.914	1.00
287_N	293_S	0.913	1.00
245_L	249_K	0.911	1.00
17_L	21_N	0.910	1.00
214_R	259_Q	0.907	1.00
91_S	94_I	0.905	1.00
255_L	276_L	0.903	1.00
43_Y	46_E	0.900	1.00
213_H	217_N	0.895	1.00
181_V	225_A	0.893	1.00
37_M	150_S	0.889	1.00
228_L	241_I	0.885	1.00
252_K	255_L	0.882	1.00
188_V	219_A	0.881	1.00
25_E	29_S	0.879	1.00
217_N	252_K	0.871	1.00
281_T	286_Y	0.868	1.00
126_Y	133_L	0.868	1.00
23_L	27_R	0.867	1.00
254_I	275_H	0.864	1.00
189_S	193_K	0.864	1.00
247_N	290_V	0.856	1.00
125_D	135_K	0.855	1.00
111_A	129_I	0.855	1.00
223_E	227_S	0.852	1.00
141_I	156_V	0.851	1.00
290_V	294_E	0.851	1.00
117_L	267_T	0.848	1.00
76_G	83_I	0.843	1.00
13_L	66_R	0.842	1.00
248_K	283_S	0.838	1.00
231_E	238_Y	0.833	1.00
183_S	275_H	0.832	1.00
127_I	156_V	0.832	1.00
25_E	78_K	0.828	1.00
66_R	70_I	0.826	1.00
177_A	242_A	0.825	1.00
142_R	157_D	0.825	1.00
276_L	280_L	0.822	1.00
60_L	97_K	0.821	1.00
95_K	98_D	0.819	1.00
214_R	260_V	0.816	1.00
282_L	286_Y	0.815	1.00
209_Q	213_H	0.813	1.00
184_G	249_K	0.812	1.00
187_V	275_H	0.809	1.00
129_I	132_R	0.806	1.00
37_M	42_D	0.802	1.00
190_M	275_H	0.802	1.00
24_L	28_W	0.801	1.00
191_S	260_V	0.801	1.00
21_N	78_K	0.801	1.00
39_G	268_D	0.800	1.00
191_S	195_S	0.797	1.00
177_A	229_I	0.795	1.00
108_I	126_Y	0.789	1.00
180_M	247_N	0.788	1.00
158_N	161_N	0.785	1.00
16_I	67_D	0.785	1.00
191_S	261_H	0.784	1.00
22_E	25_E	0.782	1.00
21_N	77_R	0.781	1.00
90_A	94_I	0.781	1.00
193_K	196_K	0.779	1.00
258_I	265_G	0.779	1.00
186_E	189_S	0.775	1.00
141_I	154_S	0.772	1.00
45_E	125_D	0.766	1.00
228_L	242_A	0.765	1.00
29_S	32_K	0.760	1.00
169_N	172_I	0.757	1.00
221_D	248_K	0.757	1.00
185_E	219_A	0.753	1.00
117_L	264_I	0.751	1.00
228_L	245_L	0.750	1.00
177_A	246_A	0.750	1.00
122_D	152_K	0.749	1.00
221_D	224_L	0.747	1.00
195_S	205_I	0.747	1.00
184_G	225_A	0.744	1.00
251_P	280_L	0.744	1.00
25_E	77_R	0.743	1.00
261_H	272_I	0.742	1.00
166_E	170_A	0.740	1.00
95_K	101_N	0.738	1.00
220_I	245_L	0.737	1.00
229_I	246_A	0.734	1.00
258_I	272_I	0.733	1.00
121_A	141_I	0.730	1.00
12_D	15_L	0.727	1.00
225_A	245_L	0.727	1.00
98_D	101_N	0.726	1.00
254_I	276_L	0.724	1.00
123_E	152_K	0.723	1.00
288_S	293_S	0.721	1.00
36_V	39_G	0.720	1.00
248_K	294_E	0.717	1.00
194_Y	264_I	0.715	1.00
224_L	228_L	0.712	1.00
111_A	163_E	0.712	1.00
167_V	170_A	0.709	1.00
70_I	74_V	0.708	1.00
183_S	279_A	0.708	1.00
149_S	268_D	0.706	1.00
17_L	73_E	0.701	1.00
142_R	145_N	0.696	1.00
211_I	214_R	0.694	1.00
226_R	230_L	0.693	1.00
70_I	230_L	0.691	1.00
191_S	218_D	0.691	1.00
218_D	257_G	0.689	1.00
77_R	186_E	0.689	1.00
103_V	126_Y	0.686	1.00
176_L	287_N	0.680	1.00
271_D	274_L	0.680	1.00
125_D	134_I	0.679	1.00
132_R	138_N	0.678	1.00
148_D	151_M	0.671	1.00
144_F	155_K	0.670	1.00
51_I	56_I	0.669	1.00
211_I	215_V	0.665	1.00
132_R	135_K	0.663	1.00
45_E	109_R	0.663	1.00
205_I	208_Y	0.662	1.00
84_V	88_I	0.659	1.00
70_I	73_E	0.654	1.00
208_Y	212_K	0.654	1.00
28_W	31_K	0.650	1.00
244_D	248_K	0.650	1.00
134_I	138_N	0.649	1.00
31_K	46_E	0.649	1.00
249_K	253_A	0.649	1.00
118_V	156_V	0.649	1.00
250_I	254_I	0.648	1.00
198_R	201_F	0.648	1.00
23_L	51_I	0.644	1.00
83_I	87_S	0.642	1.00
223_E	228_L	0.638	1.00
99_I	108_I	0.635	1.00
210_A	214_R	0.634	1.00
47_I	82_G	0.628	1.00
143_T	146_S	0.626	1.00
228_L	232_A	0.624	1.00
274_L	278_R	0.622	1.00
99_I	102_R	0.620	1.00
251_P	279_A	0.619	1.00
289_K	292_I	0.617	1.00
71_I	75_I	0.616	1.00
85_V	88_I	0.615	1.00
41_K	149_S	0.615	1.00
201_F	208_Y	0.610	1.00
170_A	239_A	0.608	1.00
221_D	225_A	0.607	1.00
135_K	139_C	0.605	1.00
185_E	222_V	0.604	1.00
194_Y	197_E	0.603	1.00
68_N	175_S	0.603	1.00
254_I	272_I	0.601	1.00
223_E	241_I	0.601	1.00
200_A	205_I	0.599	1.00
169_N	173_A	0.597	1.00
12_D	67_D	0.597	1.00
267_T	270_L	0.595	1.00
264_I	267_T	0.593	1.00
237_K	241_I	0.592	1.00
220_I	224_L	0.589	1.00
186_E	271_D	0.588	1.00
232_A	238_Y	0.587	1.00
146_S	153_I	0.582	1.00
45_E	48_W	0.580	1.00
122_D	143_T	0.579	1.00
143_T	147_L	0.577	1.00
208_Y	211_I	0.571	1.00
259_Q	291_N	0.571	1.00
174_L	233_A	0.570	1.00
288_S	292_I	0.569	1.00
292_I	295_F	0.568	1.00
47_I	50_E	0.568	1.00
145_N	149_S	0.566	1.00
188_V	218_D	0.565	1.00
58_P	61_S	0.563	1.00
24_L	27_R	0.561	1.00
44_I	47_I	0.559	1.00
136_R	162_H	0.554	1.00
217_N	248_K	0.553	1.00
116_N	144_F	0.553	1.00
261_H	270_L	0.553	1.00
243_K	247_N	0.553	1.00
136_R	163_E	0.552	1.00
216_V	220_I	0.551	1.00
57_L	91_S	0.551	1.00
72_N	76_G	0.550	1.00
135_K	141_I	0.549	1.00
83_I	86_S	0.549	1.00
35_A	271_D	0.546	1.00
167_V	171_E	0.542	1.00
36_V	42_D	0.540	1.00
192_I	195_S	0.540	1.00
121_A	156_V	0.539	1.00
219_A	237_K	0.538	1.00
168_N	172_I	0.538	1.00
98_D	133_L	0.536	1.00
199_V	203_K	0.535	1.00
27_R	54_L	0.534	1.00
84_V	87_S	0.533	1.00
221_D	253_A	0.532	1.00
69_V	230_L	0.532	1.00
16_I	20_L	0.531	1.00
199_V	207_S	0.531	1.00
268_D	277_R	0.531	1.00
222_V	226_R	0.530	1.00
41_K	143_T	0.529	1.00
218_D	260_V	0.525	1.00
69_V	229_I	0.525	1.00
127_I	141_I	0.523	1.00
184_G	187_V	0.523	1.00
42_D	45_E	0.523	1.00
176_L	286_Y	0.523	1.00
199_V	202_G	0.523	1.00
38_E	277_R	0.522	1.00
28_W	47_I	0.522	1.00
96_N	99_I	0.521	1.00
178_S	182_G	0.519	1.00
37_M	40_N	0.519	1.00
287_N	292_I	0.518	1.00
181_V	184_G	0.518	1.00
263_G	266_F	0.517	1.00
41_K	268_D	0.516	1.00
118_V	121_A	0.515	1.00
133_L	137_S	0.515	1.00
115_S	243_K	0.513	1.00
18_S	21_N	0.513	1.00
259_Q	283_S	0.511	1.00
16_I	71_I	0.511	1.00
174_L	239_A	0.509	1.00
80_L	183_S	0.507	1.00
142_R	146_S	0.503	1.00
147_L	276_L	0.503	1.00
205_I	211_I	0.503	1.00
35_A	274_L	0.503	1.00
74_V	78_K	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ix5A	4	0.99	100	0.276	Contact Map
3pfdA	4	0.9532	100	0.277	Contact Map
4irnA	4	0.9666	100	0.278	Contact Map
3swoA	4	0.99	100	0.281	Contact Map
1bucA	4	0.9766	100	0.281	Contact Map
3sf6A	4	0.99	100	0.282	Contact Map
1ukwA	4	0.9766	100	0.282	Contact Map
3r7kA	4	0.9766	100	0.282	Contact Map
2d29A	4	0.9799	100	0.282	Contact Map
1siqA	4	0.99	100	0.283	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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