GREMLIN Database
Q97VV8 - Acyl-CoA dehydrogenase related protein (Acd-like2)
UniProt: Q97VV8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (281)
Sequences: 31263 (18099)
Seq/√Len: 1079.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_D252_K3.5131.00
112_I160_G3.1981.00
27_R50_E3.1391.00
214_R256_S2.9891.00
64_S67_D2.8541.00
102_R107_E2.8101.00
140_T159_I2.7401.00
21_N74_V2.6991.00
102_R108_I2.6621.00
36_V40_N2.4861.00
114_D157_D2.3971.00
193_K197_E2.3651.00
185_E226_R2.1971.00
89_V92_R2.1551.00
110_I162_H2.1381.00
210_A213_H2.1221.00
22_E26_S2.1101.00
13_L67_D2.1021.00
268_D273_H2.0181.00
114_D155_K2.0151.00
195_S260_V1.9951.00
203_K207_S1.9611.00
50_E53_K1.9451.00
188_V222_V1.9401.00
225_A246_A1.9001.00
199_V204_P1.8961.00
127_I134_I1.8791.00
273_H277_R1.8311.00
251_P283_S1.7911.00
162_H165_I1.7871.00
49_K53_K1.7751.00
252_K256_S1.7671.00
204_P207_S1.7381.00
121_A154_S1.7331.00
264_I270_L1.7101.00
74_V77_R1.6981.00
89_V93_G1.6981.00
190_M271_D1.6901.00
185_E189_S1.6821.00
140_T157_D1.6571.00
15_L19_S1.6511.00
77_R189_S1.6331.00
97_K101_N1.6271.00
98_D102_R1.6241.00
186_E190_M1.6231.00
133_L136_R1.6191.00
136_R161_N1.6161.00
73_E226_R1.6151.00
57_L60_L1.5831.00
122_D154_S1.5801.00
218_D253_A1.5631.00
15_L18_S1.5561.00
89_V94_I1.5471.00
248_K290_V1.5441.00
224_L245_L1.5281.00
200_A208_Y1.5261.00
195_S211_I1.5261.00
14_K17_L1.5211.00
18_S22_E1.5181.00
45_E49_K1.5101.00
13_L64_S1.5091.00
49_K52_I1.5071.00
192_I196_K1.4871.00
190_M261_H1.4811.00
190_M193_K1.4761.00
101_N105_A1.4721.00
203_K208_Y1.4421.00
24_L78_K1.4401.00
102_R105_A1.4381.00
17_L74_V1.4361.00
211_I260_V1.4301.00
184_G222_V1.4281.00
77_R185_E1.4091.00
144_F147_L1.4071.00
13_L70_I1.4031.00
219_A223_E1.3911.00
218_D256_S1.3821.00
50_E54_L1.3821.00
221_D249_K1.3821.00
145_N268_D1.3721.00
188_V192_I1.3601.00
59_Y62_T1.3591.00
223_E231_E1.3411.00
63_L67_D1.3361.00
187_V254_I1.3301.00
11_E15_L1.3241.00
17_L70_I1.3151.00
110_I160_G1.3101.00
250_I279_A1.3071.00
191_S257_G1.3061.00
255_L280_L1.3051.00
251_P255_L1.2971.00
142_R155_K1.2901.00
19_S54_L1.2841.00
112_I159_I1.2701.00
69_V233_A1.2671.00
244_D290_V1.2641.00
21_N25_E1.2551.00
99_I126_Y1.2551.00
184_G253_A1.2501.00
257_G272_I1.2441.00
178_S229_I1.2351.00
195_S206_G1.2331.00
217_N294_E1.2291.00
214_R291_N1.2281.00
225_A249_K1.2281.00
227_S231_E1.2231.00
14_K18_S1.2121.00
31_K37_M1.2101.00
20_L56_I1.2081.00
134_I139_C1.2001.00
96_N100_L1.1941.00
73_E185_E1.1891.00
255_L283_S1.1881.00
251_P276_L1.1881.00
280_L283_S1.1851.00
95_K99_I1.1631.00
35_A39_G1.1551.00
181_V222_V1.1441.00
134_I141_I1.1411.00
249_K252_K1.1341.00
248_K252_K1.1321.00
183_S250_I1.1231.00
73_E230_L1.1211.00
69_V178_S1.1181.00
222_V253_A1.1171.00
137_S162_H1.1171.00
23_L50_E1.1151.00
232_A242_A1.1121.00
217_N221_D1.1111.00
196_K206_G1.1021.00
139_C161_N1.1001.00
212_K295_F1.0941.00
221_D256_S1.0921.00
11_E14_K1.0871.00
106_G109_R1.0641.00
46_E50_E1.0521.00
20_L71_I1.0491.00
258_I276_L1.0491.00
19_S56_I1.0391.00
57_L104_Y1.0321.00
108_I125_D1.0241.00
24_L75_I1.0171.00
79_L82_G1.0171.00
186_E275_H1.0151.00
136_R139_C1.0131.00
129_I158_N1.0081.00
23_L54_L1.0071.00
46_E49_K1.0061.00
116_N155_K1.0051.00
213_H295_F0.9981.00
254_I279_A0.9941.00
90_A93_G0.9941.00
142_R147_L0.9931.00
19_S22_E0.9921.00
138_N161_N0.9831.00
240_W293_S0.9831.00
221_D245_L0.9651.00
139_C156_V0.9571.00
244_D294_E0.9571.00
283_S290_V0.9551.00
217_N256_S0.9541.00
187_V257_G0.9521.00
111_A130_G0.9511.00
172_I287_N0.9491.00
45_E123_E0.9491.00
192_I215_V0.9481.00
219_A241_I0.9461.00
181_V229_I0.9461.00
132_R136_R0.9431.00
195_S215_V0.9391.00
20_L24_L0.9371.00
223_E226_R0.9311.00
220_I241_I0.9311.00
180_M282_L0.9301.00
214_R217_N0.9291.00
220_I244_D0.9261.00
39_G145_N0.9251.00
127_I139_C0.9251.00
49_K107_E0.9251.00
31_K36_V0.9241.00
66_R230_L0.9141.00
287_N293_S0.9131.00
245_L249_K0.9111.00
17_L21_N0.9101.00
214_R259_Q0.9071.00
91_S94_I0.9051.00
255_L276_L0.9031.00
43_Y46_E0.9001.00
213_H217_N0.8951.00
181_V225_A0.8931.00
37_M150_S0.8891.00
228_L241_I0.8851.00
252_K255_L0.8821.00
188_V219_A0.8811.00
25_E29_S0.8791.00
217_N252_K0.8711.00
281_T286_Y0.8681.00
126_Y133_L0.8681.00
23_L27_R0.8671.00
254_I275_H0.8641.00
189_S193_K0.8641.00
247_N290_V0.8561.00
125_D135_K0.8551.00
111_A129_I0.8551.00
223_E227_S0.8521.00
141_I156_V0.8511.00
290_V294_E0.8511.00
117_L267_T0.8481.00
76_G83_I0.8431.00
13_L66_R0.8421.00
248_K283_S0.8381.00
231_E238_Y0.8331.00
183_S275_H0.8321.00
127_I156_V0.8321.00
25_E78_K0.8281.00
66_R70_I0.8261.00
177_A242_A0.8251.00
142_R157_D0.8251.00
276_L280_L0.8221.00
60_L97_K0.8211.00
95_K98_D0.8191.00
214_R260_V0.8161.00
282_L286_Y0.8151.00
209_Q213_H0.8131.00
184_G249_K0.8121.00
187_V275_H0.8091.00
129_I132_R0.8061.00
37_M42_D0.8021.00
190_M275_H0.8021.00
24_L28_W0.8011.00
191_S260_V0.8011.00
21_N78_K0.8011.00
39_G268_D0.8001.00
191_S195_S0.7971.00
177_A229_I0.7951.00
108_I126_Y0.7891.00
180_M247_N0.7881.00
158_N161_N0.7851.00
16_I67_D0.7851.00
191_S261_H0.7841.00
22_E25_E0.7821.00
21_N77_R0.7811.00
90_A94_I0.7811.00
193_K196_K0.7791.00
258_I265_G0.7791.00
186_E189_S0.7751.00
141_I154_S0.7721.00
45_E125_D0.7661.00
228_L242_A0.7651.00
29_S32_K0.7601.00
169_N172_I0.7571.00
221_D248_K0.7571.00
185_E219_A0.7531.00
117_L264_I0.7511.00
228_L245_L0.7501.00
177_A246_A0.7501.00
122_D152_K0.7491.00
221_D224_L0.7471.00
195_S205_I0.7471.00
184_G225_A0.7441.00
251_P280_L0.7441.00
25_E77_R0.7431.00
261_H272_I0.7421.00
166_E170_A0.7401.00
95_K101_N0.7381.00
220_I245_L0.7371.00
229_I246_A0.7341.00
258_I272_I0.7331.00
121_A141_I0.7301.00
12_D15_L0.7271.00
225_A245_L0.7271.00
98_D101_N0.7261.00
254_I276_L0.7241.00
123_E152_K0.7231.00
288_S293_S0.7211.00
36_V39_G0.7201.00
248_K294_E0.7171.00
194_Y264_I0.7151.00
224_L228_L0.7121.00
111_A163_E0.7121.00
167_V170_A0.7091.00
70_I74_V0.7081.00
183_S279_A0.7081.00
149_S268_D0.7061.00
17_L73_E0.7011.00
142_R145_N0.6961.00
211_I214_R0.6941.00
226_R230_L0.6931.00
70_I230_L0.6911.00
191_S218_D0.6911.00
218_D257_G0.6891.00
77_R186_E0.6891.00
103_V126_Y0.6861.00
176_L287_N0.6801.00
271_D274_L0.6801.00
125_D134_I0.6791.00
132_R138_N0.6781.00
148_D151_M0.6711.00
144_F155_K0.6701.00
51_I56_I0.6691.00
211_I215_V0.6651.00
132_R135_K0.6631.00
45_E109_R0.6631.00
205_I208_Y0.6621.00
84_V88_I0.6591.00
70_I73_E0.6541.00
208_Y212_K0.6541.00
28_W31_K0.6501.00
244_D248_K0.6501.00
134_I138_N0.6491.00
31_K46_E0.6491.00
249_K253_A0.6491.00
118_V156_V0.6491.00
250_I254_I0.6481.00
198_R201_F0.6481.00
23_L51_I0.6441.00
83_I87_S0.6421.00
223_E228_L0.6381.00
99_I108_I0.6351.00
210_A214_R0.6341.00
47_I82_G0.6281.00
143_T146_S0.6261.00
228_L232_A0.6241.00
274_L278_R0.6221.00
99_I102_R0.6201.00
251_P279_A0.6191.00
289_K292_I0.6171.00
71_I75_I0.6161.00
85_V88_I0.6151.00
41_K149_S0.6151.00
201_F208_Y0.6101.00
170_A239_A0.6081.00
221_D225_A0.6071.00
135_K139_C0.6051.00
185_E222_V0.6041.00
194_Y197_E0.6031.00
68_N175_S0.6031.00
254_I272_I0.6011.00
223_E241_I0.6011.00
200_A205_I0.5991.00
169_N173_A0.5971.00
12_D67_D0.5971.00
267_T270_L0.5951.00
264_I267_T0.5931.00
237_K241_I0.5921.00
220_I224_L0.5891.00
186_E271_D0.5881.00
232_A238_Y0.5871.00
146_S153_I0.5821.00
45_E48_W0.5801.00
122_D143_T0.5791.00
143_T147_L0.5771.00
208_Y211_I0.5711.00
259_Q291_N0.5711.00
174_L233_A0.5701.00
288_S292_I0.5691.00
292_I295_F0.5681.00
47_I50_E0.5681.00
145_N149_S0.5661.00
188_V218_D0.5651.00
58_P61_S0.5631.00
24_L27_R0.5611.00
44_I47_I0.5591.00
136_R162_H0.5541.00
217_N248_K0.5531.00
116_N144_F0.5531.00
261_H270_L0.5531.00
243_K247_N0.5531.00
136_R163_E0.5521.00
216_V220_I0.5511.00
57_L91_S0.5511.00
72_N76_G0.5501.00
135_K141_I0.5491.00
83_I86_S0.5491.00
35_A271_D0.5461.00
167_V171_E0.5421.00
36_V42_D0.5401.00
192_I195_S0.5401.00
121_A156_V0.5391.00
219_A237_K0.5381.00
168_N172_I0.5381.00
98_D133_L0.5361.00
199_V203_K0.5351.00
27_R54_L0.5341.00
84_V87_S0.5331.00
221_D253_A0.5321.00
69_V230_L0.5321.00
16_I20_L0.5311.00
199_V207_S0.5311.00
268_D277_R0.5311.00
222_V226_R0.5301.00
41_K143_T0.5291.00
218_D260_V0.5251.00
69_V229_I0.5251.00
127_I141_I0.5231.00
184_G187_V0.5231.00
42_D45_E0.5231.00
176_L286_Y0.5231.00
199_V202_G0.5231.00
38_E277_R0.5221.00
28_W47_I0.5221.00
96_N99_I0.5211.00
178_S182_G0.5191.00
37_M40_N0.5191.00
287_N292_I0.5181.00
181_V184_G0.5181.00
263_G266_F0.5171.00
41_K268_D0.5161.00
118_V121_A0.5151.00
133_L137_S0.5151.00
115_S243_K0.5131.00
18_S21_N0.5131.00
259_Q283_S0.5111.00
16_I71_I0.5111.00
174_L239_A0.5091.00
80_L183_S0.5071.00
142_R146_S0.5031.00
147_L276_L0.5031.00
205_I211_I0.5031.00
35_A274_L0.5031.00
74_V78_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ix5A 4 0.99 100 0.276 Contact Map
3pfdA 4 0.9532 100 0.277 Contact Map
4irnA 4 0.9666 100 0.278 Contact Map
3swoA 4 0.99 100 0.281 Contact Map
1bucA 4 0.9766 100 0.281 Contact Map
3sf6A 4 0.99 100 0.282 Contact Map
1ukwA 4 0.9766 100 0.282 Contact Map
3r7kA 4 0.9766 100 0.282 Contact Map
2d29A 4 0.9799 100 0.282 Contact Map
1siqA 4 0.99 100 0.283 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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