GREMLIN Database
Q97VV7 - Ribonuleotide reductase small subunit, probable (NrdB)
UniProt: Q97VV7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (274)
Sequences: 2324 (979)
Seq/√Len: 59.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_M272_V4.5911.00
58_D61_K3.9331.00
280_N293_K3.6611.00
44_I114_A3.4821.00
252_S276_K3.3801.00
62_M66_N3.2211.00
237_M289_A3.1431.00
165_R239_H2.9831.00
241_N291_R2.8411.00
57_N60_E2.7811.00
245_P291_R2.7591.00
297_L300_K2.6021.00
173_I244_A2.4851.00
168_V240_I2.4681.00
248_I292_M2.4451.00
241_N289_A2.4441.00
241_N283_I2.4091.00
238_D242_Y2.3631.00
242_Y246_Y2.2951.00
234_K238_D2.2321.00
167_V220_L2.0951.00
248_I279_L2.0651.00
175_E210_E2.0551.00
140_K143_F2.0331.00
241_N288_R2.0191.00
102_E105_V2.0071.00
249_G253_E1.9881.00
252_S272_V1.9721.00
150_A154_L1.9511.00
108_E175_E1.8731.00
65_I123_N1.8431.00
35_K40_D1.8411.00
127_D130_A1.8281.00
75_E115_F1.8171.00
245_P292_M1.8120.99
50_A54_K1.7750.99
241_N245_P1.7720.99
139_Y142_I1.7690.99
46_L117_R1.7550.99
148_P151_M1.7180.99
52_D55_K1.7160.99
210_E213_H1.7110.99
298_L301_D1.7080.99
190_T196_L1.6830.99
130_A134_D1.6120.99
240_I288_R1.6090.99
128_L131_Y1.6020.99
100_Y216_F1.5940.99
53_W61_K1.5930.99
276_K294_L1.5900.99
221_I288_R1.5820.99
114_A202_M1.5720.99
284_D290_R1.5670.99
237_M241_N1.5510.98
234_K237_M1.5460.98
148_P253_E1.5420.98
145_E149_K1.5390.98
256_M268_N1.5270.98
34_G107_E1.5170.98
205_L208_T1.5140.98
168_V286_I1.5120.98
296_M300_K1.5080.98
139_Y143_F1.4980.98
102_E109_S1.4960.98
138_N143_F1.4930.98
108_E210_E1.4800.98
161_E239_H1.4740.98
32_Q42_A1.4740.98
24_S94_R1.4630.98
65_I127_D1.4560.98
41_P114_A1.4190.97
239_H242_Y1.4180.97
26_F223_R1.4070.97
53_W65_I1.4000.97
297_L301_D1.3930.97
60_E195_I1.3920.97
35_K41_P1.3710.96
253_E256_M1.3410.96
79_A109_S1.3360.96
179_A183_Y1.3230.96
34_G104_F1.3170.96
297_L302_L1.3140.96
269_I273_D1.3110.95
56_L196_L1.2860.95
155_S158_P1.2860.95
179_A210_E1.2730.95
270_E273_D1.2660.95
111_H213_H1.2600.94
223_R227_E1.2430.94
149_K246_Y1.2430.94
152_W156_R1.2230.93
179_A206_I1.2210.93
103_Q107_E1.2210.93
30_L98_V1.2170.93
184_N255_T1.2160.93
245_P249_G1.2040.93
262_L269_I1.1910.92
273_D294_L1.1850.92
103_Q106_Y1.1810.92
225_V237_M1.1720.92
241_N290_R1.1650.92
84_P87_V1.1560.91
32_Q40_D1.1380.91
118_F199_L1.1360.91
260_E267_T1.1360.91
164_V221_I1.1250.90
149_K153_N1.1200.90
71_F78_V1.1190.90
146_E151_M1.1110.90
61_K127_D1.1040.89
51_E54_K1.1030.89
50_A121_I1.1000.89
41_P44_I1.0980.89
272_V276_K1.0980.89
177_V244_A1.0960.89
242_Y249_G1.0950.89
229_G232_V1.0840.88
184_N300_K1.0770.88
201_K205_L1.0770.88
158_P161_E1.0680.88
230_E233_Y1.0540.87
224_L227_E1.0530.87
111_H209_D1.0490.87
237_M288_R1.0430.86
255_T275_A1.0370.86
70_K254_P1.0250.85
98_V102_E1.0180.85
25_L29_K1.0100.85
63_F258_Q1.0080.84
108_E179_A1.0020.84
228_Y232_V1.0000.84
191_N200_A0.9980.84
141_K253_E0.9980.84
151_M158_P0.9910.83
214_I281_T0.9850.83
153_N165_R0.9810.83
171_N214_I0.9810.83
262_L268_N0.9800.83
222_T225_V0.9770.83
64_I199_L0.9760.83
44_I205_L0.9670.82
32_Q113_E0.9660.82
165_R236_A0.9630.82
54_K124_V0.9590.81
28_M32_Q0.9580.81
35_K110_K0.9530.81
162_N165_R0.9490.81
128_L132_T0.9460.80
59_L261_S0.9440.80
261_S264_F0.9420.80
249_G295_E0.9420.80
187_R207_A0.9360.80
26_F29_K0.9330.80
214_I282_R0.9300.79
48_K52_D0.9250.79
277_K281_T0.9220.79
218_I285_A0.9210.79
239_H243_L0.9200.79
225_V232_V0.9190.79
280_N290_R0.9180.78
273_D295_E0.9170.78
55_K153_N0.9170.78
171_N217_G0.9140.78
151_M154_L0.9110.78
296_M301_D0.9090.78
32_Q36_K0.9050.77
168_V244_A0.9040.77
142_I253_E0.9040.77
164_V224_L0.9020.77
58_D269_I0.8990.77
129_S133_K0.8960.77
155_S159_S0.8950.77
183_Y213_H0.8880.76
46_L202_M0.8880.76
149_K152_W0.8860.76
175_E179_A0.8850.76
41_P117_R0.8800.75
183_Y210_E0.8790.75
249_G252_S0.8680.74
221_I286_I0.8650.74
141_K144_Y0.8620.74
186_F203_V0.8580.74
276_K292_M0.8500.73
99_M109_S0.8460.73
176_G282_R0.8450.72
59_L262_L0.8410.72
181_G275_A0.8400.72
83_H86_I0.8390.72
48_K51_E0.8360.72
63_F185_I0.8340.71
116_R120_D0.8310.71
191_N204_N0.8290.71
175_E183_Y0.8290.71
57_N272_V0.8270.71
175_E213_H0.8250.71
54_K242_Y0.8220.70
61_K65_I0.8170.70
145_E148_P0.8160.70
75_E199_L0.8140.70
223_R226_K0.8100.69
290_R293_K0.8060.69
146_E154_L0.8050.69
41_P110_K0.8040.69
138_N142_I0.8030.69
276_K280_N0.8020.68
45_D48_K0.8010.68
231_G234_K0.8010.68
82_L104_F0.7990.68
150_A153_N0.7980.68
75_E209_D0.7970.68
27_P223_R0.7960.68
157_D161_E0.7940.68
225_V228_Y0.7900.67
26_F219_Y0.7880.67
30_L215_A0.7880.67
159_S162_N0.7880.67
224_L228_Y0.7860.67
142_I146_E0.7800.66
141_K145_E0.7760.66
38_F103_Q0.7740.66
152_W155_S0.7720.66
79_A105_V0.7710.65
55_K195_I0.7680.65
173_I247_A0.7660.65
40_D110_K0.7650.65
31_Y113_E0.7630.65
128_L133_K0.7560.64
102_E239_H0.7550.64
278_L282_R0.7540.64
75_E179_A0.7520.63
55_K58_D0.7490.63
126_E130_A0.7490.63
289_A293_K0.7490.63
269_I272_V0.7460.63
99_M102_E0.7450.63
163_Q167_V0.7410.62
75_E213_H0.7330.61
298_L302_L0.7310.61
252_S256_M0.7270.61
66_N131_Y0.7270.61
139_Y144_Y0.7270.61
71_F182_G0.7250.61
150_A158_P0.7240.61
272_V275_A0.7230.60
34_G216_F0.7220.60
182_G206_I0.7210.60
34_G100_Y0.7170.60
248_I276_K0.7170.60
230_E234_K0.7160.60
88_T166_A0.7120.59
173_I240_I0.7110.59
161_E165_R0.7110.59
47_S50_A0.7060.59
211_S215_A0.7040.58
157_D160_P0.7040.58
64_I71_F0.7020.58
56_L61_K0.7020.58
225_V288_R0.6970.58
221_I228_Y0.6920.57
131_Y134_D0.6910.57
89_L163_Q0.6890.57
34_G37_L0.6850.56
209_D213_H0.6830.56
219_Y223_R0.6830.56
129_S132_T0.6820.56
78_V82_L0.6800.56
284_D293_K0.6770.55
28_M31_Y0.6760.55
154_L158_P0.6720.55
260_E264_F0.6690.55
115_F183_Y0.6680.54
177_V181_G0.6670.54
158_P162_N0.6630.54
38_F106_Y0.6630.54
68_G119_F0.6600.54
111_H183_Y0.6570.53
44_I208_T0.6540.53
165_R243_L0.6530.53
140_K146_E0.6530.53
45_D198_G0.6530.53
104_F179_A0.6490.52
196_L202_M0.6490.52
161_E233_Y0.6490.52
106_Y110_K0.6480.52
93_G227_E0.6450.52
46_L198_G0.6450.52
124_V127_D0.6440.52
130_A133_K0.6430.52
179_A213_H0.6400.51
264_F273_D0.6370.51
27_P219_Y0.6360.51
117_R120_D0.6360.51
248_I252_S0.6350.51
118_F180_E0.6330.51
149_K192_T0.6330.51
226_K242_Y0.6330.51
161_E235_A0.6320.50
237_M242_Y0.6310.50
111_H210_E0.6300.50
97_E220_L0.6280.50
174_V186_F0.6270.50
85_L166_A0.6270.50
26_F41_P0.6260.50
244_A279_L0.6260.50
34_G103_Q0.6250.50
145_E150_A0.6240.50
27_P97_E0.6220.49
75_E277_K0.6170.49
56_L263_P0.6150.49
176_G214_I0.6150.49
54_K59_L0.6150.49
51_E253_E0.6110.48
251_F254_P0.6090.48
173_I243_L0.6090.48
183_Y251_F0.6070.48
24_S27_P0.6040.47
57_N130_A0.6010.47
75_E217_G0.5990.47
61_K273_D0.5990.47
119_F177_V0.5980.47
58_D240_I0.5960.46
289_A294_L0.5950.46
39_W111_H0.5950.46
280_N283_I0.5940.46
216_F219_Y0.5920.46
140_K151_M0.5880.46
29_K33_L0.5870.45
148_P154_L0.5860.45
270_E298_L0.5850.45
168_V225_V0.5840.45
20_G129_S0.5820.45
216_F220_L0.5820.45
154_L159_S0.5800.45
69_S211_S0.5770.44
238_D241_N0.5760.44
72_A119_F0.5750.44
226_K288_R0.5740.44
30_L216_F0.5720.44
35_K103_Q0.5720.44
74_G114_A0.5700.44
75_E111_H0.5690.43
89_L167_V0.5690.43
24_S225_V0.5680.43
255_T272_V0.5680.43
59_L62_M0.5650.43
108_E213_H0.5640.43
34_G212_R0.5630.43
229_G233_Y0.5630.43
162_N252_S0.5630.43
283_I291_R0.5620.43
236_A288_R0.5610.43
151_M157_D0.5600.42
85_L88_T0.5590.42
140_K144_Y0.5570.42
102_E106_Y0.5570.42
28_M113_E0.5550.42
267_T270_E0.5530.42
97_E216_F0.5520.42
24_S223_R0.5520.42
55_K289_A0.5520.42
66_N275_A0.5510.41
161_E236_A0.5480.41
221_I289_A0.5460.41
74_G78_V0.5450.41
44_I198_G0.5450.41
64_I196_L0.5430.41
221_I236_A0.5420.41
103_Q109_S0.5410.40
55_K156_R0.5410.40
173_I274_Y0.5400.40
115_F213_H0.5390.40
26_F224_L0.5380.40
146_E155_S0.5370.40
38_F74_G0.5370.40
168_V236_A0.5370.40
248_I293_K0.5370.40
276_K296_M0.5350.40
249_G284_D0.5350.40
58_D256_M0.5350.40
249_G256_M0.5330.40
248_I275_A0.5330.40
54_K62_M0.5330.40
192_T201_K0.5330.40
75_E254_P0.5320.39
196_L245_P0.5310.39
214_I277_K0.5310.39
280_N292_M0.5300.39
73_A205_L0.5300.39
184_N275_A0.5290.39
52_D190_T0.5290.39
53_W204_N0.5280.39
153_N156_R0.5250.39
72_A259_V0.5250.39
149_K156_R0.5250.39
141_K146_E0.5250.39
118_F122_V0.5240.39
158_P238_D0.5230.38
58_D289_A0.5230.38
225_V287_N0.5210.38
79_A86_I0.5200.38
39_W49_D0.5190.38
78_V174_V0.5170.38
60_E193_R0.5110.37
103_Q110_K0.5110.37
153_N246_Y0.5100.37
256_M260_E0.5100.37
101_L217_G0.5050.37
185_I200_A0.5030.36
176_G213_H0.5010.36
81_D104_F0.5010.36
237_M269_I0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1mxrA 2 0.9643 100 0.174 Contact Map
2rccA 4 0.9545 100 0.174 Contact Map
1syyA 2 0.9545 100 0.174 Contact Map
3oljA 2 0.9188 100 0.192 Contact Map
2o1zA 2 0.9091 100 0.2 Contact Map
4bmoA 2 0.9156 100 0.203 Contact Map
3n37A 2 0.9123 100 0.203 Contact Map
1jk0B 1 0.8247 100 0.206 Contact Map
3dhzA 2 0.9351 100 0.209 Contact Map
1jk0A 1 0.9253 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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