GREMLIN Database
Q97VV3 - 4-hydroxybutyryl-CoA dehydratase (AbfD-1)
UniProt: Q97VV3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (455)
Sequences: 803 (510)
Seq/√Len: 23.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
175_R251_D7.9661.00
129_R133_E5.6381.00
8_L37_A5.2901.00
392_G396_V4.9761.00
22_K30_H4.6111.00
10_S188_D4.4971.00
338_P345_A4.4571.00
174_V209_F4.4341.00
26_D29_T4.1881.00
12_K26_D3.7291.00
172_I259_V3.7201.00
168_K253_F3.6921.00
387_L409_A3.6511.00
53_D56_M3.5481.00
164_V262_F3.4931.00
4_K45_E3.4741.00
256_W259_V3.4721.00
303_Q455_E3.4501.00
189_E258_R3.3541.00
168_K173_V3.2021.00
125_K128_E3.1421.00
170_D253_F3.0961.00
302_S317_I3.0771.00
167_V263_K3.0281.00
12_K28_T3.0051.00
172_I207_V2.9861.00
221_Y248_V2.9811.00
52_E58_K2.9401.00
210_A260_F2.9171.00
387_L395_I2.8720.99
167_V262_F2.8320.99
313_V373_I2.6380.99
298_S320_I2.6230.99
365_D368_R2.5470.99
319_D365_D2.5000.99
61_K74_D2.4640.98
173_V253_F2.4530.98
53_D59_M2.4300.98
300_V459_K2.4220.98
6_D9_K2.4170.98
162_V174_V2.4140.98
16_N219_K2.3860.98
166_D170_D2.3280.98
54_N59_M2.3240.98
182_T223_R2.2870.97
166_D251_D2.1920.97
22_K385_E2.1530.96
248_V394_N2.1000.96
162_V249_F2.0830.95
2_R10_S2.0740.95
3_S6_D2.0650.95
292_N328_R2.0250.95
121_K125_K2.0200.95
126_Y189_E2.0040.94
404_D407_E1.9830.94
307_I313_V1.9810.94
5_E9_K1.9790.94
2_R188_D1.9730.94
166_D173_V1.9700.94
339_V348_N1.8910.92
68_T345_A1.8750.92
70_Q74_D1.8260.91
204_D263_K1.7900.90
86_C90_F1.7840.90
297_A418_L1.7660.89
222_I243_L1.7630.89
67_W71_D1.7610.89
145_K377_I1.7560.89
172_I253_F1.7300.88
316_D372_D1.7070.88
143_D178_K1.7030.88
16_N23_L1.6470.86
84_M289_A1.6310.85
80_Y84_M1.6200.85
112_D117_T1.6080.84
164_V207_V1.5530.82
96_I139_T1.5500.82
224_P234_S1.5200.81
51_Y54_N1.5170.81
165_V173_V1.5090.80
76_H335_A1.5030.80
452_K456_N1.5000.80
4_K41_A1.4900.79
291_M366_V1.4900.79
125_K129_R1.4810.79
113_R341_M1.4710.78
312_H316_D1.4670.78
221_Y394_N1.4620.78
256_W262_F1.4350.77
47_A60_S1.4350.77
126_Y129_R1.4260.76
43_L82_L1.4140.76
126_Y210_A1.3910.74
200_D265_Y1.3760.74
192_V249_F1.3730.73
371_I432_I1.3730.73
348_N351_F1.3690.73
211_V254_V1.3610.73
150_K154_E1.3490.72
126_Y258_R1.3420.72
50_V56_M1.3390.71
121_K124_E1.3230.71
406_E410_K1.3150.70
303_Q308_E1.3000.69
375_G378_I1.2950.69
281_F335_A1.2920.69
450_N453_E1.2810.68
365_D369_D1.2800.68
69_S345_A1.2780.68
86_C360_N1.2700.67
165_V175_R1.2640.67
118_D121_K1.2620.67
55_K128_E1.2620.67
129_R135_L1.2570.67
379_A382_P1.2490.66
276_A279_H1.2470.66
395_I409_A1.2470.66
264_E267_Y1.2460.66
219_K394_N1.2440.66
259_V262_F1.2420.66
299_K451_F1.2390.65
173_V207_V1.2290.65
211_V215_T1.2190.64
87_N461_V1.2130.64
321_I451_F1.2110.64
377_I382_P1.2080.63
295_L320_I1.2080.63
212_P254_V1.2080.63
136_T183_Q1.2060.63
304_V403_V1.2010.63
302_S307_I1.2010.63
285_S331_A1.1990.63
167_V256_W1.1990.63
159_D163_R1.1920.62
21_G386_D1.1870.62
294_Y415_A1.1860.62
368_R432_I1.1860.62
301_A415_A1.1840.62
41_A390_D1.1790.61
190_I213_A1.1750.61
244_E290_T1.1720.61
14_G214_N1.1680.61
275_F279_H1.1610.60
248_V398_Y1.1610.60
173_V251_D1.1590.60
426_Y430_G1.1580.60
157_D205_Y1.1540.60
191_I324_K1.1440.59
52_E56_M1.1430.59
209_F254_V1.1360.58
194_P205_Y1.1290.58
12_K29_T1.1260.58
254_V258_R1.1250.58
153_S202_D1.1240.58
54_N57_G1.1230.58
35_T38_L1.1140.57
223_R242_E1.1130.57
301_A373_I1.1130.57
53_D57_G1.1100.57
122_R259_V1.1080.57
122_R257_D1.1070.56
163_R204_D1.1030.56
140_A181_T1.1010.56
375_G437_S1.0970.56
426_Y431_M1.0920.55
235_V417_E1.0920.55
129_R189_E1.0880.55
416_K420_A1.0850.55
53_D132_K1.0840.55
192_V209_F1.0830.55
126_Y137_L1.0800.55
135_L189_E1.0760.54
242_E426_Y1.0750.54
184_S220_M1.0730.54
17_L169_S1.0690.54
52_E57_G1.0660.54
12_K27_I1.0620.53
290_T431_M1.0610.53
452_K455_E1.0590.53
117_T120_S1.0520.53
69_S336_V1.0510.53
291_M359_S1.0410.52
59_M131_A1.0380.52
39_H87_N1.0320.51
364_H368_R1.0320.51
319_D369_D1.0270.51
337_Y348_N1.0240.51
316_D369_D1.0200.50
147_D150_K1.0120.50
111_V115_Y1.0110.50
50_V58_K1.0100.50
157_D397_K1.0090.50
121_K259_V1.0080.49
437_S440_A1.0070.49
219_K391_E0.9990.49
12_K214_N0.9930.48
128_E172_I0.9900.48
66_P75_R0.9870.48
170_D173_V0.9850.48
123_V127_F0.9810.48
413_K434_A0.9600.46
88_G242_E0.9520.46
332_I337_Y0.9520.46
190_I247_T0.9520.46
456_N460_R0.9500.45
329_S333_A0.9470.45
9_K12_K0.9450.45
164_V452_K0.9430.45
23_L390_D0.9410.45
326_I358_Y0.9400.45
109_K124_E0.9400.45
393_K396_V0.9340.44
261_L268_A0.9340.44
18_Y432_I0.9320.44
218_L252_V0.9310.44
178_K359_S0.9310.44
129_R137_L0.9290.44
246_L399_L0.9220.43
17_L268_A0.9200.43
129_R132_K0.9190.43
454_A457_L0.9180.43
18_Y408_R0.9160.43
16_N391_E0.9090.43
122_R174_V0.9060.42
311_K439_E0.9030.42
178_K461_V0.9030.42
69_S338_P0.9000.42
67_W125_K0.8980.42
64_K74_D0.8950.42
175_R192_V0.8950.42
8_L395_I0.8940.41
261_L264_E0.8930.41
70_Q248_V0.8930.41
146_G400_R0.8910.41
329_S351_F0.8910.41
159_D175_R0.8900.41
305_N375_G0.8860.41
377_I381_M0.8860.41
83_T282_T0.8860.41
22_K25_E0.8840.41
70_Q73_L0.8810.41
5_E218_L0.8800.41
36_A186_V0.8790.40
134_D209_F0.8770.40
248_V411_V0.8770.40
174_V343_G0.8770.40
49_R58_K0.8730.40
205_Y375_G0.8720.40
50_V53_D0.8700.40
364_H432_I0.8690.40
233_S417_E0.8690.40
33_L222_I0.8640.39
137_L210_A0.8640.39
155_Q205_Y0.8630.39
184_S213_A0.8610.39
112_D116_G0.8610.39
375_G382_P0.8590.39
276_A280_R0.8590.39
299_K317_I0.8560.39
130_V137_L0.8550.39
301_A412_L0.8540.39
24_V34_K0.8520.39
151_R154_E0.8470.38
414_L458_V0.8440.38
170_D257_D0.8400.38
433_H437_S0.8360.38
7_F129_R0.8360.38
53_D131_A0.8340.37
64_K281_F0.8340.37
203_K265_Y0.8320.37
39_H42_K0.8320.37
68_T323_Y0.8310.37
427_L434_A0.8280.37
390_D393_K0.8280.37
101_I132_K0.8270.37
61_K64_K0.8240.37
80_Y289_A0.8230.37
154_E201_S0.8200.37
56_M128_E0.8190.36
375_G379_A0.8180.36
234_S237_S0.8160.36
49_R266_D0.8160.36
242_E431_M0.8140.36
101_I130_V0.8130.36
142_T186_V0.8130.36
6_D263_K0.8120.36
192_V215_T0.8110.36
206_A376_G0.8110.36
336_V393_K0.8090.36
200_D266_D0.8090.36
20_R386_D0.8090.36
215_T252_V0.8070.36
297_A306_G0.8040.35
51_Y64_K0.8030.35
386_D414_L0.8010.35
13_D26_D0.7990.35
253_F256_W0.7980.35
242_E290_T0.7970.35
17_L164_V0.7930.35
111_V261_L0.7920.35
8_L28_T0.7910.35
216_K460_R0.7900.35
119_Y122_R0.7900.35
152_P155_Q0.7900.35
316_D438_M0.7900.35
35_T227_E0.7870.34
146_G152_P0.7860.34
103_A189_E0.7850.34
34_K38_L0.7830.34
22_K251_D0.7830.34
172_I262_F0.7820.34
71_D206_A0.7770.34
416_K426_Y0.7760.34
95_A286_Y0.7750.34
244_E430_G0.7730.33
39_H240_D0.7720.33
166_D253_F0.7700.33
60_S134_D0.7700.33
326_I330_S0.7690.33
324_K424_T0.7680.33
144_V223_R0.7680.33
177_A398_Y0.7670.33
396_V404_D0.7670.33
83_T290_T0.7640.33
244_E426_Y0.7640.33
108_A117_T0.7610.33
55_K59_M0.7570.32
172_I263_K0.7560.32
297_A415_A0.7540.32
401_G408_R0.7540.32
148_R306_G0.7520.32
7_F133_E0.7500.32
247_T260_F0.7490.32
59_M132_K0.7480.32
304_V411_V0.7470.32
94_Q416_K0.7450.32
170_D398_Y0.7430.32
23_L164_V0.7430.32
165_V251_D0.7420.32
175_R205_Y0.7380.31
153_S168_K0.7370.31
410_K458_V0.7360.31
250_N334_A0.7340.31
351_F368_R0.7340.31
183_Q427_L0.7330.31
94_Q98_S0.7330.31
5_E308_E0.7330.31
88_G223_R0.7310.31
363_F371_I0.7310.31
270_T274_L0.7310.31
23_L170_D0.7280.31
16_N128_E0.7260.31
360_N441_S0.7250.31
80_Y285_S0.7220.30
6_D70_Q0.7200.30
134_D189_E0.7200.30
56_M59_M0.7190.30
254_V304_V0.7160.30
112_D275_F0.7150.30
430_G434_A0.7150.30
381_M409_A0.7150.30
84_M457_L0.7140.30
19_Y296_G0.7140.30
242_E430_G0.7130.30
60_S78_L0.7110.30
71_D404_D0.7110.30
310_E437_S0.7100.30
331_A335_A0.7080.29
155_Q161_Y0.7070.29
50_V54_N0.7050.29
138_A181_T0.7040.29
126_Y185_A0.7020.29
284_L355_G0.7020.29
33_L36_A0.7020.29
373_I383_S0.7010.29
211_V252_V0.6990.29
8_L38_L0.6990.29
3_S10_S0.6980.29
359_S427_L0.6960.29
108_A120_S0.6920.29
118_D168_K0.6920.29
219_K248_V0.6920.29
15_R48_D0.6910.29
321_I449_Y0.6900.28
182_T242_E0.6890.28
13_D214_N0.6880.28
63_F66_P0.6870.28
215_T390_D0.6850.28
18_Y389_S0.6840.28
63_F127_F0.6830.28
202_D218_L0.6800.28
179_A413_K0.6800.28
223_R431_M0.6780.28
10_S14_G0.6760.28
16_N27_I0.6740.28
307_I400_R0.6740.28
132_K248_V0.6740.28
11_L419_G0.6730.27
6_D16_N0.6730.27
142_T441_S0.6730.27
192_V412_L0.6730.27
300_V318_V0.6730.27
301_A374_A0.6720.27
67_W166_D0.6710.27
189_E254_V0.6710.27
30_H41_A0.6710.27
416_K431_M0.6700.27
358_Y362_H0.6700.27
356_K360_N0.6700.27
244_E431_M0.6700.27
282_T290_T0.6690.27
233_S290_T0.6690.27
98_S139_T0.6690.27
388_E406_E0.6680.27
17_L395_I0.6680.27
305_N412_L0.6670.27
10_S13_D0.6670.27
413_K427_L0.6650.27
179_A182_T0.6650.27
41_A222_I0.6650.27
179_A395_I0.6640.27
109_K113_R0.6640.27
314_R443_I0.6620.27
33_L68_T0.6620.27
55_K132_K0.6620.27
220_M245_T0.6610.27
290_T426_Y0.6580.27
374_A378_I0.6570.27
259_V454_A0.6540.26
239_K410_K0.6540.26
185_A245_T0.6520.26
244_E417_E0.6520.26
227_E413_K0.6510.26
144_V426_Y0.6510.26
97_G139_T0.6510.26
172_I251_D0.6490.26
129_R450_N0.6490.26
301_A411_V0.6480.26
129_R258_R0.6480.26
150_K163_R0.6480.26
320_I366_V0.6480.26
342_E348_N0.6470.26
3_S28_T0.6470.26
42_K85_Y0.6470.26
8_L41_A0.6470.26
290_T430_G0.6470.26
17_L251_D0.6450.26
188_D343_G0.6440.26
315_D361_M0.6430.26
457_L460_R0.6420.26
300_V455_E0.6420.26
223_R430_G0.6400.26
12_K34_K0.6390.26
218_L247_T0.6390.26
282_T426_Y0.6360.25
321_I378_I0.6350.25
17_L73_L0.6350.25
19_Y39_H0.6340.25
179_A246_L0.6340.25
371_I428_L0.6330.25
94_Q143_D0.6330.25
49_R57_G0.6330.25
174_V254_V0.6320.25
218_L249_F0.6300.25
144_V177_A0.6280.25
382_P408_R0.6270.25
243_L418_L0.6270.25
420_A425_G0.6240.25
115_Y268_A0.6240.25
286_Y426_Y0.6230.25
52_E266_D0.6230.25
149_S306_G0.6230.25
284_L395_I0.6220.25
316_D375_G0.6210.25
24_V29_T0.6210.25
396_V460_R0.6190.25
83_T86_C0.6190.25
167_V257_D0.6180.24
219_K389_S0.6160.24
307_I366_V0.6140.24
63_F398_Y0.6140.24
204_D364_H0.6140.24
18_Y23_L0.6140.24
245_T362_H0.6140.24
216_K344_I0.6130.24
55_K165_V0.6130.24
389_S392_G0.6120.24
241_Y286_Y0.6120.24
286_Y431_M0.6120.24
181_T247_T0.6120.24
215_T239_K0.6120.24
368_R374_A0.6110.24
18_Y219_K0.6110.24
318_V322_L0.6090.24
39_H395_I0.6070.24
197_V371_I0.6060.24
80_Y292_N0.6060.24
300_V411_V0.6060.24
60_S260_F0.6050.24
162_V207_V0.6030.24
137_L191_I0.6030.24
76_H329_S0.6030.24
299_K302_S0.6030.24
2_R133_E0.6020.24
3_S35_T0.6020.24
114_K266_D0.6010.24
223_R426_Y0.6010.24
257_D338_P0.6010.24
326_I354_V0.5990.23
46_Y81_D0.5980.23
394_N398_Y0.5980.23
249_F260_F0.5970.23
266_D452_K0.5970.23
128_E132_K0.5950.23
145_K149_S0.5940.23
144_V242_E0.5920.23
168_K256_W0.5920.23
19_Y24_V0.5920.23
40_A409_A0.5910.23
213_A220_M0.5890.23
233_S407_E0.5880.23
68_T71_D0.5870.23
65_V105_M0.5870.23
440_A444_E0.5870.23
73_L336_V0.5860.23
145_K148_R0.5860.23
36_A90_F0.5850.23
190_I220_M0.5850.23
11_L147_D0.5850.23
27_I37_A0.5850.23
314_R318_V0.5850.23
413_K420_A0.5840.23
182_T414_L0.5840.23
10_S183_Q0.5840.23
113_R124_E0.5840.23
26_D452_K0.5820.23
248_V405_G0.5820.23
113_R154_E0.5790.22
118_D122_R0.5770.22
12_K239_K0.5750.22
294_Y456_N0.5740.22
9_K17_L0.5730.22
374_A397_K0.5720.22
392_G405_G0.5720.22
339_V349_P0.5710.22
236_L417_E0.5680.22
280_R356_K0.5680.22
23_L166_D0.5680.22
241_Y431_M0.5660.22
119_Y128_E0.5660.22
89_V418_L0.5660.22
29_T396_V0.5650.22
12_K25_E0.5650.22
224_P458_V0.5640.22
56_M78_L0.5640.22
57_G132_K0.5630.22
169_S256_W0.5630.22
275_F278_F0.5620.22
73_L335_A0.5620.22
181_T184_S0.5610.22
212_P260_F0.5610.22
132_K370_L0.5590.22
211_V249_F0.5590.22
397_K459_K0.5590.22
16_N452_K0.5580.21
68_T309_N0.5580.21
277_T347_P0.5570.21
66_P366_V0.5570.21
65_V102_F0.5570.21
96_I435_E0.5560.21
44_Y136_T0.5550.21
250_N333_A0.5550.21
298_S317_I0.5540.21
9_K169_S0.5540.21
325_E328_R0.5530.21
141_Q441_S0.5520.21
211_V258_R0.5520.21
123_V276_A0.5520.21
88_G417_E0.5500.21
326_I329_S0.5500.21
135_L258_R0.5500.21
29_T173_V0.5490.21
211_V341_M0.5480.21
229_E234_S0.5480.21
291_M324_K0.5480.21
154_E350_L0.5480.21
75_R134_D0.5480.21
168_K393_K0.5480.21
189_E210_A0.5470.21
311_K437_S0.5460.21
214_N303_Q0.5450.21
2_R130_V0.5450.21
397_K458_V0.5450.21
76_H80_Y0.5440.21
87_N240_D0.5430.21
282_T431_M0.5410.21
24_V456_N0.5410.21
168_K175_R0.5400.21
389_S393_K0.5390.21
125_K219_K0.5380.21
223_R244_E0.5380.21
365_D397_K0.5370.20
95_A417_E0.5360.20
179_A376_G0.5350.20
20_R149_S0.5350.20
138_A185_A0.5350.20
210_A258_R0.5340.20
317_I341_M0.5340.20
112_D305_N0.5330.20
4_K144_V0.5330.20
112_D115_Y0.5330.20
254_V312_H0.5320.20
6_D174_V0.5310.20
420_A429_T0.5310.20
28_T35_T0.5300.20
108_A278_F0.5300.20
128_E452_K0.5280.20
171_G256_W0.5280.20
335_A338_P0.5280.20
113_R162_V0.5270.20
129_R452_K0.5270.20
88_G244_E0.5270.20
95_A181_T0.5270.20
235_V238_R0.5270.20
372_D375_G0.5260.20
22_K31_Q0.5260.20
192_V406_E0.5260.20
39_H85_Y0.5260.20
248_V389_S0.5250.20
419_G428_L0.5250.20
121_K214_N0.5240.20
182_T240_D0.5240.20
82_L369_D0.5240.20
24_V307_I0.5230.20
296_G458_V0.5230.20
46_Y85_Y0.5220.20
130_V210_A0.5220.20
242_E417_E0.5220.20
152_P159_D0.5220.20
24_V33_L0.5220.20
279_H353_N0.5210.20
66_P102_F0.5190.20
11_L29_T0.5180.20
113_R216_K0.5180.20
215_T249_F0.5180.20
427_L431_M0.5180.20
94_Q139_T0.5180.20
95_A426_Y0.5160.20
140_A192_V0.5160.20
17_L124_E0.5160.20
175_R219_K0.5150.19
317_I320_I0.5150.19
11_L93_S0.5140.19
124_E453_E0.5140.19
155_Q163_R0.5140.19
79_I185_A0.5130.19
7_F254_V0.5130.19
126_Y332_I0.5120.19
22_K70_Q0.5100.19
291_M434_A0.5100.19
23_L44_Y0.5100.19
292_N324_K0.5090.19
9_K77_K0.5090.19
76_H285_S0.5090.19
47_A189_E0.5090.19
373_I415_A0.5070.19
163_R404_D0.5060.19
60_S82_L0.5060.19
20_R177_A0.5050.19
145_K194_P0.5040.19
169_S257_D0.5040.19
186_V289_A0.5040.19
31_Q204_D0.5030.19
189_E260_F0.5030.19
216_K251_D0.5020.19
136_T327_M0.5020.19
202_D376_G0.5010.19
96_I434_A0.5010.19
337_Y351_F0.5010.19
180_H430_G0.5000.19
34_K227_E0.5000.19
312_H437_S0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hwcA 4 0.9849 100 0.494 Contact Map
4g5eA 4 0.9654 100 0.496 Contact Map
2yykA 3 0.9762 100 0.511 Contact Map
4oo2A 4 0.9827 100 0.513 Contact Map
1u8vA 3 0.9849 100 0.52 Contact Map
4l1fA 4 0.7559 99.7 0.892 Contact Map
1rx0A 4 0.7516 99.7 0.893 Contact Map
1ukwA 4 0.7559 99.7 0.893 Contact Map
5af7A 4 0.7689 99.7 0.893 Contact Map
1ivhA 4 0.7797 99.7 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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