GREMLIN Database
Q97VV1 - Transcriptional regulator, putative
UniProt: Q97VV1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 198 (181)
Sequences: 45075 (35637)
Seq/√Len: 2648.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_S49_Y4.1511.00
31_K40_D4.0461.00
26_D44_K3.6901.00
57_K61_D2.7451.00
28_I36_T2.3941.00
58_S61_D2.3241.00
42_T52_F2.1331.00
27_L40_D2.1221.00
27_L44_K2.1021.00
17_L65_E2.0591.00
30_E44_K2.0061.00
18_N69_K1.9911.00
27_L36_T1.9681.00
27_L31_K1.9271.00
23_A44_K1.9211.00
136_K154_E1.8751.00
19_K23_A1.8631.00
39_S43_N1.8631.00
87_N90_E1.8511.00
16_S19_K1.8491.00
23_A26_D1.7581.00
136_K140_K1.7411.00
140_K144_D1.6941.00
48_A51_L1.6861.00
91_M141_E1.6361.00
38_I53_Y1.6251.00
18_N22_N1.6221.00
21_I65_E1.5981.00
25_L69_K1.5811.00
24_S28_I1.5731.00
26_D30_E1.5731.00
17_L55_Y1.5461.00
140_K143_M1.5401.00
37_S40_D1.5271.00
25_L70_F1.5211.00
140_K153_P1.5031.00
40_D44_K1.4881.00
38_I49_Y1.4861.00
36_T41_I1.4501.00
155_L186_D1.4251.00
143_M150_K1.4241.00
141_E145_R1.4181.00
159_V163_I1.4101.00
40_D43_N1.4071.00
97_A184_Y1.3871.00
15_E19_K1.3841.00
65_E68_R1.3831.00
24_S62_I1.3771.00
120_R123_M1.3751.00
25_L66_L1.3501.00
32_G36_T1.3381.00
93_K188_A1.3301.00
69_K73_D1.3201.00
56_F65_E1.3141.00
31_K35_N1.2971.00
93_K185_N1.2821.00
142_A148_I1.2811.00
51_L54_F1.2751.00
23_A27_L1.2721.00
64_D68_R1.2651.00
22_N69_K1.2641.00
38_I52_F1.2331.00
89_I93_K1.2091.00
90_E94_E1.1861.00
32_G35_N1.1811.00
116_A120_R1.1801.00
49_Y53_Y1.1781.00
28_I33_F1.1631.00
132_A136_K1.1601.00
143_M151_V1.1601.00
77_Y98_K1.1561.00
142_A147_E1.1501.00
15_E18_N1.1391.00
47_V51_L1.1391.00
138_G142_A1.1341.00
50_G54_F1.1291.00
93_K97_A1.1281.00
23_A45_A1.1231.00
51_L55_Y1.1101.00
152_D155_L1.1051.00
109_Y112_V1.1011.00
97_A181_K1.0971.00
52_F62_I1.0841.00
60_H64_D1.0731.00
97_A185_N1.0681.00
16_S55_Y1.0641.00
41_I62_I1.0621.00
48_A54_F1.0571.00
61_D65_E1.0561.00
94_E97_A1.0551.00
22_N26_D1.0381.00
21_I66_L1.0381.00
179_L182_K1.0331.00
162_G166_M1.0311.00
108_K111_K1.0221.00
81_N98_K1.0211.00
21_I56_F1.0211.00
24_S66_L1.0191.00
79_K134_R1.0181.00
33_F63_L1.0101.00
31_K44_K0.9971.00
25_L29_S0.9881.00
171_Y174_W0.9821.00
53_Y58_S0.9801.00
77_Y80_V0.9761.00
155_L182_K0.9741.00
86_R94_E0.9681.00
102_W106_N0.9671.00
110_Y113_F0.9581.00
61_D64_D0.9561.00
13_G54_F0.9551.00
42_T49_Y0.9311.00
14_K18_N0.9311.00
134_R137_I0.9301.00
108_K112_V0.9181.00
70_F73_D0.9181.00
90_E93_K0.9171.00
68_R72_T0.9141.00
137_I141_E0.9131.00
182_K186_D0.9051.00
133_E137_I0.9031.00
94_E98_K0.9011.00
97_A188_A0.9011.00
85_I91_M0.8981.00
16_S47_V0.8901.00
116_A119_H0.8761.00
151_V156_L0.8751.00
141_E144_D0.8741.00
69_K72_T0.8711.00
76_Y80_V0.8701.00
49_Y54_F0.8671.00
115_E119_H0.8621.00
185_N189_I0.8611.00
186_D189_I0.8611.00
81_N94_E0.8601.00
12_K15_E0.8541.00
97_A101_E0.8491.00
19_K45_A0.8461.00
26_D108_K0.8401.00
27_L30_E0.8371.00
154_E158_Y0.8361.00
130_K134_R0.8351.00
137_I140_K0.8341.00
87_N147_E0.8331.00
143_M148_I0.8321.00
132_A158_Y0.8311.00
43_N49_Y0.8291.00
98_K101_E0.8261.00
29_S108_K0.8241.00
143_M153_P0.8221.00
65_E69_K0.8201.00
75_R79_K0.8161.00
125_I129_T0.8131.00
93_K189_I0.8031.00
21_I69_K0.7971.00
79_K83_M0.7951.00
11_E15_E0.7921.00
126_W130_K0.7891.00
181_K185_N0.7861.00
86_R90_E0.7861.00
117_Q121_P0.7801.00
72_T76_Y0.7801.00
12_K16_S0.7801.00
118_V121_P0.7791.00
184_Y187_L0.7731.00
13_G16_S0.7711.00
133_E136_K0.7701.00
111_K115_E0.7681.00
19_K22_N0.7641.00
125_I128_F0.7601.00
101_E184_Y0.7581.00
20_I52_F0.7571.00
104_S180_T0.7541.00
85_I90_E0.7531.00
129_T133_E0.7521.00
20_I45_A0.7521.00
128_F132_A0.7501.00
170_R174_W0.7491.00
88_R145_R0.7391.00
21_I25_L0.7321.00
184_Y188_A0.7311.00
16_S51_L0.7301.00
111_K114_V0.7191.00
88_R142_A0.7151.00
31_K36_T0.7131.00
11_E14_K0.7131.00
136_K153_P0.7051.00
96_L160_L0.7021.00
138_G141_E0.7011.00
139_L142_A0.6981.00
33_F59_K0.6911.00
162_G165_E0.6911.00
143_M146_G0.6911.00
170_R173_L0.6871.00
73_D76_Y0.6851.00
68_R127_H0.6851.00
153_P157_A0.6761.00
91_M138_G0.6591.00
75_R130_K0.6581.00
155_L158_Y0.6551.00
127_H130_K0.6491.00
30_E40_D0.6481.00
22_N25_L0.6481.00
110_Y114_V0.6441.00
38_I42_T0.6381.00
84_G94_E0.6311.00
124_Y127_H0.6301.00
181_K184_Y0.6191.00
75_R134_R0.6191.00
45_A48_A0.6151.00
80_V98_K0.6141.00
108_K116_A0.6041.00
33_F60_H0.6041.00
108_K114_V0.6001.00
20_I55_Y0.6001.00
101_E105_Q0.5961.00
155_L159_V0.5951.00
102_W105_Q0.5911.00
136_K157_A0.5901.00
185_N188_A0.5891.00
180_T184_Y0.5881.00
39_S53_Y0.5881.00
49_Y52_F0.5871.00
91_M142_A0.5851.00
117_Q120_R0.5831.00
186_D190_L0.5811.00
163_I166_M0.5801.00
93_K96_L0.5781.00
81_N84_G0.5771.00
183_Q187_L0.5761.00
152_D186_D0.5731.00
101_E181_K0.5731.00
159_V162_G0.5691.00
140_K154_E0.5671.00
85_I94_E0.5661.00
139_L143_M0.5661.00
34_L119_H0.5651.00
33_F36_T0.5641.00
169_R173_L0.5621.00
76_Y79_K0.5611.00
124_Y128_F0.5601.00
178_G181_K0.5591.00
101_E180_T0.5571.00
180_T183_Q0.5521.00
127_H131_L0.5511.00
38_I59_K0.5491.00
106_N109_Y0.5431.00
178_G182_K0.5411.00
112_V116_A0.5401.00
160_L191_I0.5401.00
16_S20_I0.5391.00
87_N91_M0.5381.00
156_L159_V0.5351.00
96_L99_F0.5321.00
132_A154_E0.5321.00
163_I187_L0.5271.00
128_F131_L0.5191.00
60_H120_R0.5191.00
11_E16_S0.5181.00
142_A145_R0.5171.00
150_K156_L0.5151.00
25_L73_D0.5151.00
135_Y142_A0.5141.00
39_S48_A0.5121.00
130_K133_E0.5091.00
14_K17_L0.5081.00
60_H121_P0.5051.00
17_L56_F0.5041.00
42_T47_V0.5031.00
34_L116_A0.5021.00
16_S48_A0.5011.00
152_D156_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ibdA 2 0.9394 100 0.202 Contact Map
4jykA 2 0.9545 100 0.214 Contact Map
3npiA 2 0.9394 100 0.215 Contact Map
3dcfA 2 0.904 100 0.223 Contact Map
2qtqA 2 0.9596 100 0.223 Contact Map
3on2A 1 0.9646 100 0.224 Contact Map
3ppbA 2 0.9293 100 0.226 Contact Map
3g1oA 2 0.9394 100 0.227 Contact Map
3bjbA 4 0.9444 100 0.227 Contact Map
3aqtA 2 0.9141 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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