GREMLIN Database
Q97VU9 - Acetyl-CoA c-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-6)
UniProt: Q97VU9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (344)
Sequences: 15285 (8574)
Seq/√Len: 462.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_I174_N3.6211.00
224_S228_L3.5921.00
163_Q288_E3.4961.00
101_A104_I3.1661.00
169_V189_V3.0931.00
339_A351_Q3.0601.00
89_I336_L2.9751.00
222_R226_S2.9611.00
27_E30_D2.9481.00
170_I173_Y2.8501.00
224_S227_A2.7801.00
177_Y181_A2.7621.00
155_K200_Y2.6851.00
259_S263_A2.6471.00
96_I219_V2.5931.00
25_T105_L2.5531.00
28_A218_V2.4611.00
103_T220_S2.3941.00
96_I221_K2.2551.00
233_I340_L2.2011.00
259_S366_W2.1971.00
160_T163_Q2.1881.00
92_A104_I2.1581.00
21_L44_A2.1351.00
237_G263_A2.1311.00
6_A9_L2.1271.00
343_L348_N2.1201.00
180_K185_N2.1031.00
272_A317_T2.0851.00
35_N38_D2.0601.00
220_S225_K2.0131.00
232_D344_N1.9931.00
162_E166_R1.9761.00
215_H333_G1.9181.00
318_G342_Q1.8961.00
179_P183_F1.8941.00
153_H159_T1.8921.00
192_V205_L1.8791.00
234_L368_R1.8721.00
220_S224_S1.8521.00
237_G259_S1.8421.00
28_A32_A1.8401.00
38_D228_L1.8261.00
265_F350_H1.8241.00
176_S183_F1.8241.00
287_M315_I1.8081.00
344_N369_R1.7751.00
342_Q346_M1.7421.00
257_T261_K1.7411.00
102_E221_K1.7341.00
287_M294_E1.7341.00
270_V273_F1.7241.00
256_T354_G1.7141.00
191_D194_K1.7121.00
271_D348_N1.6791.00
102_E224_S1.6751.00
217_F333_G1.6651.00
147_A199_S1.6581.00
92_A219_V1.6541.00
221_K224_S1.6401.00
44_A107_I1.6391.00
156_L247_E1.6261.00
265_F270_V1.6221.00
267_L273_F1.6131.00
76_E91_R1.6101.00
95_A101_A1.6071.00
21_L64_I1.6041.00
169_V173_Y1.5911.00
94_K100_D1.5871.00
176_S180_K1.5731.00
27_E31_I1.5611.00
25_T64_I1.5581.00
166_R170_I1.5381.00
26_D30_D1.5351.00
272_A342_Q1.5301.00
111_K114_H1.5171.00
166_R189_V1.5151.00
19_E67_Y1.5151.00
170_I294_E1.5131.00
173_Y186_P1.5121.00
254_T257_T1.5011.00
131_D134_I1.4931.00
103_T224_S1.4871.00
273_F352_V1.4781.00
342_Q345_D1.4571.00
24_V216_V1.4551.00
265_F366_W1.4181.00
270_V366_W1.4181.00
173_Y177_Y1.4071.00
90_Y365_W1.3991.00
258_E261_K1.3921.00
24_V214_F1.3821.00
260_A267_L1.3721.00
239_A259_S1.3691.00
15_K23_E1.3551.00
337_E341_L1.3321.00
7_G11_K1.3321.00
293_V314_P1.3291.00
239_A258_E1.3081.00
151_Y200_Y1.3071.00
336_L367_S1.3061.00
22_K67_Y1.3021.00
176_S186_P1.2861.00
255_P364_G1.2791.00
159_T164_R1.2741.00
6_A11_K1.2721.00
163_Q166_R1.2711.00
60_P109_G1.2701.00
223_S227_A1.2641.00
257_T289_D1.2581.00
72_P244_P1.2581.00
89_I217_F1.2551.00
352_V366_W1.2541.00
40_D101_A1.2511.00
83_P363_I1.2491.00
44_A216_V1.2471.00
340_L344_N1.2411.00
317_T342_Q1.2391.00
4_G337_E1.2351.00
105_L218_V1.2311.00
90_Y238_E1.2301.00
349_G368_R1.2291.00
23_E27_E1.2191.00
9_L330_M1.2101.00
39_V103_T1.2041.00
236_Y368_R1.1921.00
148_M200_Y1.1911.00
46_I49_G1.1861.00
250_D253_Y1.1841.00
38_D224_S1.1781.00
256_T352_V1.1771.00
161_D203_H1.1771.00
123_T127_D1.1711.00
43_M104_I1.1561.00
152_R156_L1.1421.00
266_D269_R1.1401.00
222_R225_K1.1381.00
167_I283_V1.1371.00
241_W254_T1.1361.00
334_V338_E1.1291.00
270_V350_H1.1091.00
147_A198_V1.1081.00
86_L336_L1.1071.00
8_K11_K1.1061.00
130_F135_K1.1041.00
122_K126_I1.1041.00
83_P357_V1.1021.00
271_D314_P1.1001.00
40_D102_E1.0961.00
92_A106_C1.0951.00
167_I284_M1.0911.00
267_L270_V1.0861.00
169_V192_V1.0861.00
133_Y138_D1.0831.00
87_S91_R1.0781.00
272_A346_M1.0741.00
235_A365_W1.0711.00
237_G262_R1.0711.00
176_S185_N1.0681.00
243_N250_D1.0651.00
187_I192_V1.0641.00
97_K100_D1.0631.00
121_Q126_I1.0621.00
100_D262_R1.0601.00
25_T70_I1.0591.00
347_A369_R1.0551.00
45_N84_S1.0541.00
89_I219_V1.0511.00
157_F250_D1.0491.00
172_R183_F1.0351.00
189_V193_L1.0291.00
159_T284_M1.0271.00
339_A353_K1.0181.00
42_I65_S1.0151.00
263_A366_W1.0131.00
271_D343_L1.0041.00
253_Y257_T1.0031.00
136_I139_Q0.9981.00
222_R234_L0.9971.00
195_S205_L0.9911.00
94_K98_A0.9901.00
38_D227_A0.9871.00
317_T346_M0.9811.00
292_L315_I0.9761.00
241_W258_E0.9751.00
24_V27_E0.9701.00
188_T191_D0.9681.00
29_L70_I0.9621.00
151_Y155_K0.9581.00
122_K127_D0.9561.00
169_V186_P0.9511.00
118_N131_D0.9501.00
250_D289_D0.9461.00
156_L246_A0.9411.00
236_Y350_H0.9401.00
22_K26_D0.9401.00
215_H330_M0.9341.00
176_S184_R0.9331.00
162_E193_L0.9301.00
93_Y235_A0.9251.00
4_G28_A0.9241.00
5_F337_E0.9241.00
196_R204_L0.9221.00
195_S203_H0.9201.00
247_E250_D0.9191.00
258_E262_R0.9171.00
173_Y176_S0.9151.00
70_I73_K0.9141.00
270_V352_V0.9101.00
270_V357_V0.9101.00
181_A345_D0.9091.00
318_G345_D0.9081.00
28_A105_L0.9031.00
24_V28_A0.9021.00
339_A358_I0.9021.00
153_H250_D0.9011.00
273_F292_L0.8971.00
16_D19_E0.8961.00
131_D135_K0.8951.00
130_F134_I0.8921.00
237_G366_W0.8921.00
232_D340_L0.8901.00
29_L34_L0.8881.00
275_L354_G0.8861.00
93_Y97_K0.8801.00
215_H337_E0.8771.00
43_M88_M0.8691.00
335_I353_K0.8631.00
106_C217_F0.8621.00
272_A339_A0.8621.00
4_G32_A0.8581.00
256_T290_I0.8581.00
220_S230_N0.8571.00
280_T322_L0.8491.00
43_M76_E0.8471.00
80_Y87_S0.8471.00
265_F357_V0.8461.00
250_D285_L0.8441.00
321_S331_S0.8391.00
154_S281_I0.8371.00
170_I295_K0.8371.00
235_A238_E0.8351.00
157_F289_D0.8341.00
66_E72_P0.8341.00
165_A206_E0.8331.00
9_L324_T0.8301.00
152_R155_K0.8271.00
287_M292_L0.8261.00
43_M92_A0.8161.00
135_K139_Q0.8151.00
350_H368_R0.8141.00
153_H285_L0.8121.00
88_M333_G0.8111.00
175_A183_F0.8081.00
42_I73_K0.8071.00
44_A61_P0.8071.00
336_L365_W0.8041.00
132_E135_K0.8031.00
5_F341_L0.8031.00
40_D258_E0.8021.00
21_L107_I0.8001.00
17_G109_G0.7961.00
187_I191_D0.7941.00
243_N251_I0.7921.00
130_F133_Y0.7881.00
39_V105_L0.7881.00
133_Y136_I0.7871.00
179_P185_N0.7871.00
29_L39_V0.7871.00
95_A100_D0.7851.00
52_H114_H0.7841.00
243_N254_T0.7831.00
223_S226_S0.7831.00
86_L365_W0.7821.00
38_D103_T0.7781.00
318_G346_M0.7761.00
197_I200_Y0.7751.00
206_E280_T0.7731.00
105_L216_V0.7731.00
100_D238_E0.7711.00
253_Y289_D0.7711.00
28_A216_V0.7701.00
150_A281_I0.7691.00
283_V287_M0.7641.00
123_T126_I0.7631.00
131_D138_D0.7621.00
339_A360_L0.7621.00
41_G95_A0.7591.00
174_N177_Y0.7581.00
175_A179_P0.7521.00
139_Q142_P0.7511.00
15_K19_E0.7501.00
257_T290_I0.7491.00
134_I138_D0.7471.00
256_T364_G0.7441.00
162_E189_V0.7441.00
91_R94_K0.7361.00
40_D104_I0.7301.00
138_D142_P0.7301.00
265_F269_R0.7291.00
130_F136_I0.7291.00
134_I140_M0.7291.00
350_H366_W0.7281.00
41_G240_H0.7281.00
163_Q284_M0.7271.00
135_K138_D0.7271.00
187_I205_L0.7221.00
183_F186_P0.7171.00
169_V187_I0.7171.00
94_K97_K0.7161.00
18_I52_H0.7141.00
268_N314_P0.7131.00
357_V363_I0.7101.00
347_A350_H0.7091.00
113_S212_D0.7071.00
232_D341_L0.7051.00
91_R95_A0.7051.00
275_L286_Q0.7051.00
169_V191_D0.7051.00
124_D127_D0.7041.00
220_S228_L0.7041.00
46_I52_H0.7031.00
23_E26_D0.7031.00
46_I60_P0.7021.00
149_V248_W0.6981.00
148_M152_R0.6961.00
177_Y180_K0.6961.00
267_L292_L0.6951.00
29_L36_Y0.6951.00
169_V188_T0.6941.00
260_A265_F0.6911.00
217_F337_E0.6891.00
175_A323_N0.6881.00
26_D36_Y0.6881.00
190_E194_K0.6881.00
16_D114_H0.6861.00
132_E136_I0.6851.00
259_S352_V0.6851.00
256_T275_L0.6811.00
231_I235_A0.6801.00
131_D136_I0.6771.00
135_K140_M0.6761.00
70_I105_L0.6691.00
172_R176_S0.6681.00
29_L33_G0.6671.00
232_D236_Y0.6671.00
134_I137_Y0.6661.00
47_G328_A0.6661.00
102_E262_R0.6651.00
285_L289_D0.6651.00
225_K228_L0.6601.00
132_E137_Y0.6601.00
343_L351_Q0.6591.00
102_E227_A0.6561.00
236_Y263_A0.6551.00
80_Y240_H0.6541.00
4_G31_I0.6531.00
122_K125_I0.6531.00
150_A154_S0.6521.00
95_A104_I0.6511.00
74_I240_H0.6501.00
340_L367_S0.6491.00
268_N291_G0.6491.00
172_R186_P0.6491.00
145_D148_M0.6471.00
138_D143_I0.6471.00
172_R322_L0.6471.00
32_A218_V0.6441.00
324_T334_V0.6441.00
7_G24_V0.6421.00
244_P247_E0.6421.00
221_K225_K0.6421.00
25_T68_F0.6411.00
123_T128_S0.6411.00
202_L207_I0.6391.00
25_T216_V0.6391.00
103_T228_L0.6361.00
44_A64_I0.6361.00
21_L109_G0.6320.99
19_E22_K0.6320.99
5_F9_L0.6320.99
183_F209_Y0.6310.99
36_Y71_K0.6310.99
43_M91_R0.6300.99
15_K114_H0.6280.99
9_L211_I0.6280.99
90_Y363_I0.6270.99
76_E87_S0.6260.99
159_T163_Q0.6260.99
137_Y140_M0.6230.99
25_T29_L0.6230.99
144_S246_A0.6230.99
198_V204_L0.6190.99
15_K111_K0.6180.99
22_K68_F0.6180.99
78_V91_R0.6170.99
86_L353_K0.6150.99
219_V235_A0.6140.99
236_Y265_F0.6140.99
92_A101_A0.6120.99
59_N361_N0.6110.99
130_F139_Q0.6100.99
112_I328_A0.6100.99
256_T267_L0.6090.99
283_V315_I0.6090.99
130_F137_Y0.6090.99
153_H157_F0.6060.99
26_D68_F0.6020.99
331_S335_I0.6010.99
273_F354_G0.6000.99
278_S326_Q0.6000.99
64_I68_F0.6000.99
49_G77_H0.6000.99
18_I67_Y0.5970.99
261_K266_D0.5960.99
271_D350_H0.5960.99
41_G80_Y0.5950.99
7_G20_L0.5940.99
89_I106_C0.5940.99
134_I139_Q0.5930.99
133_Y137_Y0.5900.99
165_A193_L0.5900.99
336_L353_K0.5900.99
144_S148_M0.5890.99
165_A189_V0.5880.99
29_L32_A0.5860.99
150_A202_L0.5860.99
4_G8_K0.5850.99
271_D349_G0.5850.99
239_A262_R0.5830.99
166_R294_E0.5830.99
175_A324_T0.5820.99
257_T291_G0.5810.99
176_S179_P0.5780.99
8_K23_E0.5780.99
137_Y141_S0.5770.99
320_G323_N0.5770.99
245_P248_W0.5760.99
133_Y139_Q0.5760.99
330_M333_G0.5760.99
41_G101_A0.5760.99
282_T286_Q0.5760.99
89_I333_G0.5740.99
65_S75_I0.5720.99
231_I234_L0.5720.99
352_V355_A0.5710.99
97_K238_E0.5700.99
39_V70_I0.5700.99
107_I216_V0.5700.99
324_T338_E0.5680.99
121_Q124_D0.5680.99
168_A280_T0.5660.99
284_M288_E0.5650.99
119_H126_I0.5650.99
189_V192_V0.5620.99
357_V361_N0.5620.99
26_D69_G0.5610.99
65_S70_I0.5610.99
159_T288_E0.5610.99
136_I140_M0.5610.99
260_A263_A0.5590.99
88_M106_C0.5570.99
14_E114_H0.5530.99
147_A201_P0.5520.99
9_L334_V0.5510.99
43_M78_V0.5510.99
259_S270_V0.5500.99
233_I343_L0.5490.99
133_Y145_D0.5490.99
135_K141_S0.5480.99
337_E340_L0.5480.99
144_S152_R0.5470.99
131_D137_Y0.5460.98
256_T286_Q0.5460.98
351_Q367_S0.5450.98
40_D73_K0.5440.98
7_G23_E0.5430.98
42_I105_L0.5420.98
333_G337_E0.5400.98
240_H363_I0.5380.98
170_I283_V0.5350.98
168_A172_R0.5340.98
255_P259_S0.5330.98
132_E138_D0.5320.98
157_F285_L0.5320.98
287_M293_V0.5310.98
157_F247_E0.5300.98
43_M95_A0.5300.98
174_N294_E0.5290.98
87_S95_A0.5280.98
64_I109_G0.5280.98
87_S90_Y0.5270.98
281_I285_L0.5260.98
173_Y189_V0.5250.98
181_A318_G0.5230.98
95_A98_A0.5210.98
31_I341_L0.5210.98
12_N15_K0.5210.98
275_L283_V0.5200.98
133_Y140_M0.5200.98
25_T42_I0.5190.98
245_P249_D0.5160.98
117_D122_K0.5150.98
151_Y202_L0.5140.98
34_L218_V0.5140.98
177_Y349_G0.5140.98
167_I320_G0.5100.98
186_P191_D0.5100.98
278_S282_T0.5080.98
154_S159_T0.5060.98
161_D195_S0.5050.97
243_N247_E0.5050.97
164_R202_L0.5050.97
288_E291_G0.5040.97
84_S329_Y0.5020.97
157_F288_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9816 100 0.236 Contact Map
4u4eA 1 0.9 100 0.308 Contact Map
4e1lA 4 0.9053 100 0.344 Contact Map
2wu9A 2 0.9053 100 0.346 Contact Map
1ulqA 4 0.9237 100 0.346 Contact Map
1wdkC 2 0.9053 100 0.346 Contact Map
2vu1A 4 0.9132 100 0.349 Contact Map
4o9aA 4 0.9158 100 0.35 Contact Map
4nzsA 4 0.9158 100 0.352 Contact Map
1wl4A 4 0.9132 100 0.352 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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