Q97VU6 - SULSO - GREMLIN Contacts

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Q97VU6 - Acyl-CoA dehydrogenase (Acd-4)

UniProt:	Q97VU6	Sequences: MSKNEDELEEYRIKVREWIRNNVPEEIRAKGDMAPPDVLREWQRRIYEAGYLGVSWPKEYGGWGENPIKEIIVREEFAKAGVPYATVGLGVSVVGPAIILNGTEEQKKKHIRRILTAEDVWCQGFSEPQAGSDLAGIKTKAEDKGEYFLVNGQKIWSSYAHLANYCLLLTRTGDVSERHKGLTMLIVDMKSEGIRVSPIKQITGRSEFNTVYFNNVKVPKENVVGKIGEGWKVAMSTLNYERLNIGTILFTVERLIRELSINNDQLFNTAEEIVALKSFYKRILERLKKGYIAGPEAAVIKLVASEAIQRVYENAMANMGIEGLVMEREPGFRPEIAYGFLASRSITIAGGTSEILRNLLGEVVLGLPKG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	370 (347)
Sequences:	33352 (18668)
Seq/√Len:	1002.1

ECOLI - CAIA YDIO AIDB FADE
BACSU - ACDC ACDA ACDB FADE YDBM
HALSA - Q9HS75 Q9HRI6 Q9HPT2 Q9HRB3 Q9HQF0 Q9HMK7
SULSO - Q97VU6 Q97U78 Q97UW6 Q97V73 Q97YZ6 Q97WQ8 Q97XW3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_Y	217_K	4.200	1.00
151_N	215_N	3.716	1.00
272_E	310_R	3.454	1.00
22_N	45_R	3.131	1.00
143_D	220_K	2.928	1.00
113_R	118_E	2.890	1.00
104_E	108_K	2.865	1.00
195_R	214_N	2.829	1.00
66_N	69_K	2.729	1.00
16_R	76_E	2.632	1.00
265_Q	314_N	2.484	1.00
113_R	119_D	2.469	1.00
183_T	223_V	2.431	1.00
144_K	217_K	2.427	1.00
153_Q	212_Y	2.313	1.00
29_A	35_P	2.290	1.00
254_R	277_K	2.159	1.00
285_E	289_K	2.109	1.00
226_K	229_E	2.088	1.00
17_E	21_N	1.990	1.00
104_E	107_K	1.989	1.00
170_T	185_L	1.988	1.00
326_M	337_A	1.970	1.00
337_A	341_L	1.936	1.00
144_K	147_Y	1.932	1.00
57_P	99_I	1.904	1.00
103_T	106_Q	1.887	1.00
229_E	232_K	1.873	1.00
153_Q	210_T	1.866	1.00
8_L	69_K	1.833	1.00
166_C	189_M	1.808	1.00
75_E	277_K	1.803	1.00
306_E	353_S	1.794	1.00
44_R	48_E	1.783	1.00
45_R	48_E	1.756	1.00
148_F	185_L	1.747	1.00
257_R	273_I	1.719	1.00
122_C	166_C	1.709	1.00
160_A	209_N	1.706	1.00
79_K	258_E	1.705	1.00
76_E	79_K	1.691	1.00
286_R	296_E	1.687	1.00
149_L	217_K	1.664	1.00
142_E	151_N	1.650	1.00
254_R	258_E	1.612	1.00
219_P	222_N	1.599	1.00
282_R	286_R	1.598	1.00
195_R	212_Y	1.590	1.00
259_L	335_E	1.584	1.00
148_F	220_K	1.579	1.00
149_L	215_N	1.569	1.00
188_D	222_N	1.560	1.00
58_K	64_G	1.554	1.00
322_E	328_R	1.552	1.00
109_K	221_E	1.537	1.00
9_E	12_R	1.531	1.00
269_T	311_V	1.527	1.00
191_S	216_V	1.525	1.00
161_H	209_N	1.520	1.00
275_A	303_V	1.519	1.00
146_E	220_K	1.518	1.00
109_K	113_R	1.517	1.00
108_K	112_R	1.515	1.00
13_I	17_E	1.504	1.00
276_L	304_A	1.499	1.00
127_E	154_K	1.497	1.00
10_E	13_I	1.485	1.00
197_S	212_Y	1.485	1.00
197_S	210_T	1.461	1.00
19_I	80_A	1.460	1.00
113_R	116_T	1.450	1.00
81_G	84_Y	1.447	1.00
68_I	285_E	1.438	1.00
10_E	14_K	1.435	1.00
146_E	217_K	1.432	1.00
223_V	227_I	1.432	1.00
310_R	314_N	1.429	1.00
8_L	66_N	1.426	1.00
188_D	191_S	1.424	1.00
151_N	214_N	1.424	1.00
309_Q	347_T	1.423	1.00
255_L	259_L	1.415	1.00
220_K	223_V	1.411	1.00
274_V	282_R	1.404	1.00
8_L	72_I	1.401	1.00
144_K	149_L	1.391	1.00
101_N	236_S	1.370	1.00
126_S	156_W	1.369	1.00
256_I	312_Y	1.366	1.00
105_E	109_K	1.365	1.00
60_Y	107_K	1.363	1.00
143_D	227_I	1.362	1.00
269_T	314_N	1.358	1.00
40_R	44_R	1.351	1.00
106_Q	110_H	1.349	1.00
313_E	344_R	1.346	1.00
259_L	262_N	1.333	1.00
54_V	73_V	1.327	1.00
75_E	281_K	1.326	1.00
75_E	254_R	1.326	1.00
79_K	254_R	1.323	1.00
67_P	288_K	1.318	1.00
15_V	51_Y	1.308	1.00
302_L	353_S	1.308	1.00
189_M	194_I	1.304	1.00
141_A	185_L	1.293	1.00
143_D	147_Y	1.287	1.00
124_G	157_S	1.285	1.00
12_R	76_E	1.284	1.00
26_E	30_K	1.284	1.00
44_R	47_Y	1.281	1.00
201_Q	326_M	1.278	1.00
143_D	146_E	1.267	1.00
257_R	261_I	1.265	1.00
114_I	121_W	1.265	1.00
150_V	185_L	1.265	1.00
129_Q	138_K	1.256	1.00
112_R	116_T	1.248	1.00
270_A	274_V	1.247	1.00
147_Y	220_K	1.247	1.00
218_V	222_N	1.245	1.00
282_R	285_E	1.225	1.00
9_E	13_I	1.222	1.00
268_N	357_R	1.215	1.00
286_R	291_Y	1.212	1.00
105_E	221_E	1.206	1.00
109_K	222_N	1.206	1.00
45_R	49_A	1.202	1.00
65_E	69_K	1.200	1.00
313_E	347_T	1.199	1.00
71_I	284_L	1.196	1.00
172_T	183_T	1.193	1.00
191_S	222_N	1.192	1.00
119_D	164_N	1.189	1.00
26_E	29_A	1.187	1.00
253_E	273_I	1.185	1.00
194_I	216_V	1.182	1.00
308_I	343_S	1.177	1.00
309_Q	313_E	1.175	1.00
260_S	315_A	1.172	1.00
14_K	49_A	1.171	1.00
239_N	294_G	1.171	1.00
56_W	115_L	1.166	1.00
12_R	72_I	1.159	1.00
259_L	319_M	1.155	1.00
142_E	149_L	1.153	1.00
110_H	165_Y	1.152	1.00
78_A	85_A	1.147	1.00
66_N	288_K	1.147	1.00
265_Q	354_E	1.146	1.00
255_L	339_G	1.136	1.00
169_L	184_M	1.132	1.00
107_K	111_I	1.132	1.00
273_I	311_V	1.128	1.00
47_Y	52_L	1.128	1.00
276_L	307_A	1.123	1.00
71_I	247_T	1.122	1.00
315_A	336_I	1.115	1.00
32_D	201_Q	1.110	1.00
241_E	350_G	1.108	1.00
253_E	311_V	1.102	1.00
247_T	280_Y	1.097	1.00
141_A	170_T	1.091	1.00
231_W	235_M	1.090	1.00
344_R	347_T	1.086	1.00
168_L	187_V	1.084	1.00
105_E	108_K	1.077	1.00
121_W	165_Y	1.075	1.00
148_F	172_T	1.070	1.00
272_E	314_N	1.067	1.00
28_R	32_D	1.065	1.00
272_E	307_A	1.065	1.00
298_A	356_L	1.064	1.00
102_G	106_Q	1.057	1.00
189_M	196_V	1.056	1.00
140_K	151_N	1.054	1.00
193_G	216_V	1.044	1.00
169_L	182_L	1.042	1.00
306_E	310_R	1.040	1.00
124_G	166_C	1.040	1.00
100_L	236_S	1.038	1.00
44_R	118_E	1.036	1.00
94_V	121_W	1.036	1.00
139_T	150_V	1.033	1.00
106_Q	186_I	1.032	1.00
32_D	35_P	1.028	1.00
143_D	148_F	1.024	1.00
150_V	168_L	1.024	1.00
271_E	299_V	1.020	1.00
260_S	318_N	1.019	1.00
302_L	357_R	1.017	1.00
14_K	51_Y	1.016	1.00
59_E	108_K	1.013	1.00
309_Q	340_F	1.005	1.00
347_T	353_S	1.001	1.00
278_S	282_R	1.001	1.00
133_D	136_G	0.995	1.00
16_R	20_R	0.991	1.00
168_L	213_F	0.988	1.00
142_E	173_G	0.986	1.00
185_L	223_V	0.980	1.00
307_A	310_R	0.979	1.00
15_V	19_I	0.979	1.00
142_E	215_N	0.971	1.00
18_W	45_R	0.967	1.00
194_I	211_V	0.966	1.00
106_Q	222_N	0.965	1.00
166_C	194_I	0.963	1.00
217_K	220_K	0.962	1.00
56_W	95_G	0.960	1.00
312_Y	343_S	0.956	1.00
268_N	272_E	0.954	1.00
148_F	227_I	0.952	1.00
124_G	213_F	0.952	1.00
156_W	322_E	0.951	1.00
183_T	227_I	0.944	1.00
293_A	296_E	0.944	1.00
249_L	346_I	0.942	1.00
101_N	233_V	0.941	1.00
250_F	273_I	0.939	1.00
173_G	177_E	0.938	1.00
41_E	44_R	0.935	1.00
155_I	210_T	0.935	1.00
250_F	280_Y	0.927	1.00
15_V	73_V	0.926	1.00
353_S	357_R	0.926	1.00
109_K	188_D	0.924	1.00
150_V	170_T	0.917	1.00
68_I	288_K	0.917	1.00
166_C	211_V	0.915	1.00
316_M	340_F	0.909	1.00
264_D	268_N	0.909	1.00
283_I	300_I	0.907	1.00
165_Y	188_D	0.907	1.00
306_E	347_T	0.906	1.00
272_E	303_V	0.903	1.00
305_S	353_S	0.903	1.00
160_A	196_V	0.902	1.00
59_E	104_E	0.898	1.00
94_V	167_L	0.894	1.00
270_A	299_V	0.893	1.00
122_C	163_A	0.891	1.00
261_I	266_L	0.891	1.00
256_I	339_G	0.889	1.00
18_W	49_A	0.885	1.00
173_G	181_G	0.885	1.00
205_R	345_S	0.883	1.00
31_G	341_L	0.883	1.00
306_E	357_R	0.882	1.00
264_D	358_N	0.875	1.00
192_E	217_K	0.871	1.00
203_T	340_F	0.870	1.00
150_V	218_V	0.869	1.00
14_K	17_E	0.864	1.00
265_Q	318_N	0.863	1.00
57_P	60_Y	0.861	1.00
26_E	41_E	0.858	1.00
156_W	325_V	0.858	1.00
19_I	77_F	0.857	1.00
164_N	190_K	0.855	1.00
258_E	262_N	0.853	1.00
171_R	182_L	0.845	1.00
125_F	238_L	0.841	1.00
32_D	326_M	0.841	1.00
147_Y	219_P	0.837	1.00
345_S	349_A	0.836	1.00
119_D	165_Y	0.835	1.00
309_Q	344_R	0.829	1.00
274_V	277_K	0.827	1.00
40_R	164_N	0.825	1.00
55_S	70_E	0.824	1.00
132_S	355_I	0.824	1.00
68_I	72_I	0.824	1.00
252_V	339_G	0.823	1.00
196_V	211_V	0.821	1.00
68_I	281_K	0.820	1.00
252_V	308_I	0.819	1.00
145_G	217_K	0.819	1.00
263_N	358_N	0.818	1.00
18_W	22_N	0.817	1.00
148_F	223_V	0.808	1.00
346_I	349_A	0.808	1.00
268_N	314_N	0.801	1.00
103_T	107_K	0.800	1.00
171_R	174_D	0.798	1.00
59_E	62_G	0.796	1.00
213_F	216_V	0.796	1.00
122_C	189_M	0.796	1.00
167_L	184_M	0.795	1.00
316_M	336_I	0.794	1.00
340_F	344_R	0.793	1.00
124_G	168_L	0.793	1.00
165_Y	186_I	0.792	1.00
8_L	68_I	0.791	1.00
183_T	228_G	0.789	1.00
253_E	307_A	0.788	1.00
191_S	194_I	0.786	1.00
312_Y	339_G	0.784	1.00
41_E	45_R	0.784	1.00
12_R	16_R	0.782	1.00
20_R	79_K	0.781	1.00
313_E	340_F	0.779	1.00
60_Y	104_E	0.778	1.00
42_W	84_Y	0.778	1.00
72_I	281_K	0.778	1.00
124_G	211_V	0.776	1.00
137_I	169_L	0.776	1.00
303_V	307_A	0.771	1.00
141_A	148_F	0.771	1.00
245_I	350_G	0.768	1.00
185_L	218_V	0.767	1.00
250_F	276_L	0.767	1.00
139_T	154_K	0.765	1.00
127_E	139_T	0.764	1.00
268_N	310_R	0.763	1.00
177_E	180_K	0.762	1.00
72_I	76_E	0.762	1.00
274_V	278_S	0.761	1.00
20_R	24_P	0.758	1.00
254_R	270_A	0.757	1.00
59_E	107_K	0.757	1.00
141_A	172_T	0.753	1.00
137_I	182_L	0.750	1.00
18_W	46_I	0.750	1.00
256_I	315_A	0.749	1.00
312_Y	340_F	0.749	1.00
88_G	91_V	0.745	1.00
223_V	226_K	0.745	1.00
110_H	186_I	0.744	1.00
271_E	302_L	0.743	1.00
147_Y	221_E	0.743	1.00
190_K	194_I	0.743	1.00
28_R	338_Y	0.742	1.00
95_G	114_I	0.739	1.00
338_Y	342_A	0.739	1.00
19_I	23_V	0.738	1.00
307_A	311_V	0.736	1.00
20_R	80_A	0.736	1.00
310_R	313_E	0.735	1.00
269_T	315_A	0.732	1.00
173_G	228_G	0.731	1.00
271_E	303_V	0.730	1.00
279_F	299_V	0.727	1.00
255_L	258_E	0.726	1.00
257_R	270_A	0.725	1.00
203_T	337_A	0.724	1.00
259_L	339_G	0.724	1.00
38_V	41_E	0.723	1.00
279_F	300_I	0.722	1.00
246_G	300_I	0.721	1.00
164_N	189_M	0.716	1.00
46_I	51_Y	0.715	1.00
37_D	40_R	0.712	1.00
252_V	343_S	0.711	1.00
275_A	279_F	0.707	1.00
260_S	319_M	0.705	1.00
257_R	364_V	0.704	1.00
246_G	280_Y	0.704	1.00
79_K	255_L	0.703	1.00
54_V	65_E	0.702	1.00
316_M	323_G	0.699	1.00
183_T	225_G	0.697	1.00
277_K	281_K	0.695	1.00
284_L	288_K	0.690	1.00
229_E	233_V	0.689	1.00
123_Q	234_A	0.685	1.00
143_D	149_L	0.685	1.00
317_A	344_R	0.685	1.00
295_P	363_V	0.685	1.00
37_D	41_E	0.682	1.00
29_A	32_D	0.682	1.00
290_G	293_A	0.681	1.00
272_E	275_A	0.681	1.00
17_E	20_R	0.681	1.00
265_Q	268_N	0.678	1.00
358_N	362_E	0.677	1.00
263_N	361_G	0.675	1.00
312_Y	336_I	0.674	1.00
204_G	342_A	0.673	1.00
23_V	42_W	0.671	1.00
161_H	207_E	0.670	1.00
110_H	222_N	0.670	1.00
356_L	359_L	0.669	1.00
265_Q	317_A	0.668	1.00
146_E	221_E	0.667	1.00
205_R	349_A	0.664	1.00
260_S	269_T	0.663	1.00
352_T	355_I	0.661	1.00
40_R	162_L	0.661	1.00
171_R	181_G	0.661	1.00
178_R	181_G	0.659	1.00
153_Q	197_S	0.658	1.00
308_I	312_Y	0.657	1.00
145_G	149_L	0.657	1.00
167_L	224_V	0.656	1.00
172_T	181_G	0.656	1.00
11_Y	69_K	0.653	1.00
319_M	336_I	0.652	1.00
279_F	303_V	0.652	1.00
59_E	64_G	0.650	1.00
280_Y	304_A	0.644	1.00
169_L	234_A	0.641	1.00
125_F	134_L	0.641	1.00
12_R	75_E	0.640	1.00
16_R	79_K	0.638	1.00
321_I	324_L	0.638	1.00
246_G	304_A	0.636	1.00
162_L	207_E	0.636	1.00
42_W	45_R	0.636	1.00
56_W	60_Y	0.635	1.00
253_E	276_L	0.635	1.00
137_I	171_R	0.635	1.00
247_T	251_T	0.634	1.00
24_P	27_I	0.633	1.00
220_K	227_I	0.633	1.00
150_V	187_V	0.631	1.00
114_I	165_Y	0.630	1.00
157_S	211_V	0.629	1.00
249_L	305_S	0.627	1.00
328_R	335_E	0.627	1.00
279_F	283_I	0.626	1.00
143_D	217_K	0.624	1.00
106_Q	109_K	0.622	1.00
299_V	360_L	0.620	1.00
139_T	213_F	0.619	1.00
282_R	296_E	0.616	1.00
70_E	244_N	0.615	1.00
40_R	120_V	0.615	1.00
110_H	119_D	0.614	1.00
276_L	303_V	0.612	1.00
11_Y	73_V	0.612	1.00
102_G	107_K	0.606	1.00
140_K	174_D	0.603	1.00
255_L	335_E	0.598	1.00
309_Q	343_S	0.597	1.00
128_P	153_Q	0.596	1.00
269_T	318_N	0.595	1.00
272_E	306_E	0.595	1.00
172_T	227_I	0.594	1.00
274_V	279_F	0.591	1.00
97_A	101_N	0.587	1.00
139_T	152_G	0.586	1.00
97_A	237_T	0.584	1.00
194_I	213_F	0.583	1.00
99_I	107_K	0.581	1.00
168_L	216_V	0.581	1.00
160_A	211_V	0.579	1.00
140_K	173_G	0.575	1.00
53_G	115_L	0.574	1.00
243_L	284_L	0.565	1.00
67_P	287_L	0.563	1.00
302_L	360_L	0.563	1.00
82_V	252_V	0.562	1.00
305_S	346_I	0.562	1.00
57_P	62_G	0.561	1.00
335_E	339_G	0.560	1.00
187_V	213_F	0.558	1.00
239_N	297_A	0.556	1.00
139_T	170_T	0.555	1.00
335_E	338_Y	0.551	1.00
158_S	208_F	0.551	1.00
174_D	177_E	0.551	1.00
165_Y	222_N	0.551	1.00
196_V	209_N	0.549	1.00
16_R	80_A	0.548	1.00
199_I	210_T	0.548	1.00
144_K	220_K	0.548	1.00
95_G	111_I	0.547	1.00
270_A	364_V	0.546	1.00
243_L	280_Y	0.543	1.00
27_I	338_Y	0.543	1.00
86_T	205_R	0.542	1.00
256_I	260_S	0.541	1.00
125_F	169_L	0.541	1.00
21_N	25_E	0.540	1.00
268_N	306_E	0.540	1.00
97_A	233_V	0.540	1.00
46_I	84_Y	0.539	1.00
185_L	222_N	0.538	1.00
286_R	289_K	0.536	1.00
23_V	84_Y	0.536	1.00
89_L	93_V	0.536	1.00
30_K	81_G	0.535	1.00
139_T	168_L	0.534	1.00
187_V	216_V	0.534	1.00
302_L	306_E	0.533	1.00
202_I	208_F	0.532	1.00
30_K	37_D	0.531	1.00
53_G	63_W	0.530	1.00
254_R	273_I	0.529	1.00
185_L	220_K	0.528	1.00
271_E	275_A	0.528	1.00
36_P	39_L	0.525	1.00
26_E	42_W	0.524	1.00
71_I	281_K	0.523	1.00
130_A	138_K	0.523	1.00
232_K	236_S	0.523	1.00
238_L	241_E	0.522	1.00
11_Y	15_V	0.522	1.00
226_K	233_V	0.522	1.00
173_G	178_R	0.522	1.00
355_I	358_N	0.522	1.00
14_K	63_W	0.521	1.00
170_T	183_T	0.521	1.00
60_Y	112_R	0.519	1.00
28_R	335_E	0.518	1.00
268_N	271_E	0.517	1.00
276_L	300_I	0.517	1.00
70_E	92_S	0.515	1.00
328_R	336_I	0.512	1.00
203_T	341_L	0.512	1.00
94_V	97_A	0.512	1.00
253_E	308_I	0.511	1.00
269_T	272_E	0.508	1.00
24_P	80_A	0.507	1.00
190_K	196_V	0.505	1.00
344_R	348_I	0.505	1.00
36_P	201_Q	0.504	1.00
120_V	159_Y	0.503	1.00
266_L	318_N	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jifA	4	0.9676	100	0.139	Contact Map
1ivhA	4	0.9703	100	0.14	Contact Map
4l1fA	4	0.9676	100	0.145	Contact Map
2d29A	4	0.973	100	0.145	Contact Map
4rm7A	4	0.9486	100	0.146	Contact Map
4p13A	4	0.9784	100	0.15	Contact Map
1rx0A	4	0.9649	100	0.151	Contact Map
3nf4A	4	0.9514	100	0.151	Contact Map
1ukwA	4	0.9676	100	0.151	Contact Map
4m9aA	4	0.9595	100	0.152	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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