GREMLIN Database
Q97VU6 - Acyl-CoA dehydrogenase (Acd-4)
UniProt: Q97VU6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (347)
Sequences: 33352 (18668)
Seq/√Len: 1002.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_Y217_K4.2001.00
151_N215_N3.7161.00
272_E310_R3.4541.00
22_N45_R3.1311.00
143_D220_K2.9281.00
113_R118_E2.8901.00
104_E108_K2.8651.00
195_R214_N2.8291.00
66_N69_K2.7291.00
16_R76_E2.6321.00
265_Q314_N2.4841.00
113_R119_D2.4691.00
183_T223_V2.4311.00
144_K217_K2.4271.00
153_Q212_Y2.3131.00
29_A35_P2.2901.00
254_R277_K2.1591.00
285_E289_K2.1091.00
226_K229_E2.0881.00
17_E21_N1.9901.00
104_E107_K1.9891.00
170_T185_L1.9881.00
326_M337_A1.9701.00
337_A341_L1.9361.00
144_K147_Y1.9321.00
57_P99_I1.9041.00
103_T106_Q1.8871.00
229_E232_K1.8731.00
153_Q210_T1.8661.00
8_L69_K1.8331.00
166_C189_M1.8081.00
75_E277_K1.8031.00
306_E353_S1.7941.00
44_R48_E1.7831.00
45_R48_E1.7561.00
148_F185_L1.7471.00
257_R273_I1.7191.00
122_C166_C1.7091.00
160_A209_N1.7061.00
79_K258_E1.7051.00
76_E79_K1.6911.00
286_R296_E1.6871.00
149_L217_K1.6641.00
142_E151_N1.6501.00
254_R258_E1.6121.00
219_P222_N1.5991.00
282_R286_R1.5981.00
195_R212_Y1.5901.00
259_L335_E1.5841.00
148_F220_K1.5791.00
149_L215_N1.5691.00
188_D222_N1.5601.00
58_K64_G1.5541.00
322_E328_R1.5521.00
109_K221_E1.5371.00
9_E12_R1.5311.00
269_T311_V1.5271.00
191_S216_V1.5251.00
161_H209_N1.5201.00
275_A303_V1.5191.00
146_E220_K1.5181.00
109_K113_R1.5171.00
108_K112_R1.5151.00
13_I17_E1.5041.00
276_L304_A1.4991.00
127_E154_K1.4971.00
10_E13_I1.4851.00
197_S212_Y1.4851.00
197_S210_T1.4611.00
19_I80_A1.4601.00
113_R116_T1.4501.00
81_G84_Y1.4471.00
68_I285_E1.4381.00
10_E14_K1.4351.00
146_E217_K1.4321.00
223_V227_I1.4321.00
310_R314_N1.4291.00
8_L66_N1.4261.00
188_D191_S1.4241.00
151_N214_N1.4241.00
309_Q347_T1.4231.00
255_L259_L1.4151.00
220_K223_V1.4111.00
274_V282_R1.4041.00
8_L72_I1.4011.00
144_K149_L1.3911.00
101_N236_S1.3701.00
126_S156_W1.3691.00
256_I312_Y1.3661.00
105_E109_K1.3651.00
60_Y107_K1.3631.00
143_D227_I1.3621.00
269_T314_N1.3581.00
40_R44_R1.3511.00
106_Q110_H1.3491.00
313_E344_R1.3461.00
259_L262_N1.3331.00
54_V73_V1.3271.00
75_E281_K1.3261.00
75_E254_R1.3261.00
79_K254_R1.3231.00
67_P288_K1.3181.00
15_V51_Y1.3081.00
302_L353_S1.3081.00
189_M194_I1.3041.00
141_A185_L1.2931.00
143_D147_Y1.2871.00
124_G157_S1.2851.00
12_R76_E1.2841.00
26_E30_K1.2841.00
44_R47_Y1.2811.00
201_Q326_M1.2781.00
143_D146_E1.2671.00
257_R261_I1.2651.00
114_I121_W1.2651.00
150_V185_L1.2651.00
129_Q138_K1.2561.00
112_R116_T1.2481.00
270_A274_V1.2471.00
147_Y220_K1.2471.00
218_V222_N1.2451.00
282_R285_E1.2251.00
9_E13_I1.2221.00
268_N357_R1.2151.00
286_R291_Y1.2121.00
105_E221_E1.2061.00
109_K222_N1.2061.00
45_R49_A1.2021.00
65_E69_K1.2001.00
313_E347_T1.1991.00
71_I284_L1.1961.00
172_T183_T1.1931.00
191_S222_N1.1921.00
119_D164_N1.1891.00
26_E29_A1.1871.00
253_E273_I1.1851.00
194_I216_V1.1821.00
308_I343_S1.1771.00
309_Q313_E1.1751.00
260_S315_A1.1721.00
14_K49_A1.1711.00
239_N294_G1.1711.00
56_W115_L1.1661.00
12_R72_I1.1591.00
259_L319_M1.1551.00
142_E149_L1.1531.00
110_H165_Y1.1521.00
78_A85_A1.1471.00
66_N288_K1.1471.00
265_Q354_E1.1461.00
255_L339_G1.1361.00
169_L184_M1.1321.00
107_K111_I1.1321.00
273_I311_V1.1281.00
47_Y52_L1.1281.00
276_L307_A1.1231.00
71_I247_T1.1221.00
315_A336_I1.1151.00
32_D201_Q1.1101.00
241_E350_G1.1081.00
253_E311_V1.1021.00
247_T280_Y1.0971.00
141_A170_T1.0911.00
231_W235_M1.0901.00
344_R347_T1.0861.00
168_L187_V1.0841.00
105_E108_K1.0771.00
121_W165_Y1.0751.00
148_F172_T1.0701.00
272_E314_N1.0671.00
28_R32_D1.0651.00
272_E307_A1.0651.00
298_A356_L1.0641.00
102_G106_Q1.0571.00
189_M196_V1.0561.00
140_K151_N1.0541.00
193_G216_V1.0441.00
169_L182_L1.0421.00
306_E310_R1.0401.00
124_G166_C1.0401.00
100_L236_S1.0381.00
44_R118_E1.0361.00
94_V121_W1.0361.00
139_T150_V1.0331.00
106_Q186_I1.0321.00
32_D35_P1.0281.00
143_D148_F1.0241.00
150_V168_L1.0241.00
271_E299_V1.0201.00
260_S318_N1.0191.00
302_L357_R1.0171.00
14_K51_Y1.0161.00
59_E108_K1.0131.00
309_Q340_F1.0051.00
347_T353_S1.0011.00
278_S282_R1.0011.00
133_D136_G0.9951.00
16_R20_R0.9911.00
168_L213_F0.9881.00
142_E173_G0.9861.00
185_L223_V0.9801.00
307_A310_R0.9791.00
15_V19_I0.9791.00
142_E215_N0.9711.00
18_W45_R0.9671.00
194_I211_V0.9661.00
106_Q222_N0.9651.00
166_C194_I0.9631.00
217_K220_K0.9621.00
56_W95_G0.9601.00
312_Y343_S0.9561.00
268_N272_E0.9541.00
148_F227_I0.9521.00
124_G213_F0.9521.00
156_W322_E0.9511.00
183_T227_I0.9441.00
293_A296_E0.9441.00
249_L346_I0.9421.00
101_N233_V0.9411.00
250_F273_I0.9391.00
173_G177_E0.9381.00
41_E44_R0.9351.00
155_I210_T0.9351.00
250_F280_Y0.9271.00
15_V73_V0.9261.00
353_S357_R0.9261.00
109_K188_D0.9241.00
150_V170_T0.9171.00
68_I288_K0.9171.00
166_C211_V0.9151.00
316_M340_F0.9091.00
264_D268_N0.9091.00
283_I300_I0.9071.00
165_Y188_D0.9071.00
306_E347_T0.9061.00
272_E303_V0.9031.00
305_S353_S0.9031.00
160_A196_V0.9021.00
59_E104_E0.8981.00
94_V167_L0.8941.00
270_A299_V0.8931.00
122_C163_A0.8911.00
261_I266_L0.8911.00
256_I339_G0.8891.00
18_W49_A0.8851.00
173_G181_G0.8851.00
205_R345_S0.8831.00
31_G341_L0.8831.00
306_E357_R0.8821.00
264_D358_N0.8751.00
192_E217_K0.8711.00
203_T340_F0.8701.00
150_V218_V0.8691.00
14_K17_E0.8641.00
265_Q318_N0.8631.00
57_P60_Y0.8611.00
26_E41_E0.8581.00
156_W325_V0.8581.00
19_I77_F0.8571.00
164_N190_K0.8551.00
258_E262_N0.8531.00
171_R182_L0.8451.00
125_F238_L0.8411.00
32_D326_M0.8411.00
147_Y219_P0.8371.00
345_S349_A0.8361.00
119_D165_Y0.8351.00
309_Q344_R0.8291.00
274_V277_K0.8271.00
40_R164_N0.8251.00
55_S70_E0.8241.00
132_S355_I0.8241.00
68_I72_I0.8241.00
252_V339_G0.8231.00
196_V211_V0.8211.00
68_I281_K0.8201.00
252_V308_I0.8191.00
145_G217_K0.8191.00
263_N358_N0.8181.00
18_W22_N0.8171.00
148_F223_V0.8081.00
346_I349_A0.8081.00
268_N314_N0.8011.00
103_T107_K0.8001.00
171_R174_D0.7981.00
59_E62_G0.7961.00
213_F216_V0.7961.00
122_C189_M0.7961.00
167_L184_M0.7951.00
316_M336_I0.7941.00
340_F344_R0.7931.00
124_G168_L0.7931.00
165_Y186_I0.7921.00
8_L68_I0.7911.00
183_T228_G0.7891.00
253_E307_A0.7881.00
191_S194_I0.7861.00
312_Y339_G0.7841.00
41_E45_R0.7841.00
12_R16_R0.7821.00
20_R79_K0.7811.00
313_E340_F0.7791.00
60_Y104_E0.7781.00
42_W84_Y0.7781.00
72_I281_K0.7781.00
124_G211_V0.7761.00
137_I169_L0.7761.00
303_V307_A0.7711.00
141_A148_F0.7711.00
245_I350_G0.7681.00
185_L218_V0.7671.00
250_F276_L0.7671.00
139_T154_K0.7651.00
127_E139_T0.7641.00
268_N310_R0.7631.00
177_E180_K0.7621.00
72_I76_E0.7621.00
274_V278_S0.7611.00
20_R24_P0.7581.00
254_R270_A0.7571.00
59_E107_K0.7571.00
141_A172_T0.7531.00
137_I182_L0.7501.00
18_W46_I0.7501.00
256_I315_A0.7491.00
312_Y340_F0.7491.00
88_G91_V0.7451.00
223_V226_K0.7451.00
110_H186_I0.7441.00
271_E302_L0.7431.00
147_Y221_E0.7431.00
190_K194_I0.7431.00
28_R338_Y0.7421.00
95_G114_I0.7391.00
338_Y342_A0.7391.00
19_I23_V0.7381.00
307_A311_V0.7361.00
20_R80_A0.7361.00
310_R313_E0.7351.00
269_T315_A0.7321.00
173_G228_G0.7311.00
271_E303_V0.7301.00
279_F299_V0.7271.00
255_L258_E0.7261.00
257_R270_A0.7251.00
203_T337_A0.7241.00
259_L339_G0.7241.00
38_V41_E0.7231.00
279_F300_I0.7221.00
246_G300_I0.7211.00
164_N189_M0.7161.00
46_I51_Y0.7151.00
37_D40_R0.7121.00
252_V343_S0.7111.00
275_A279_F0.7071.00
260_S319_M0.7051.00
257_R364_V0.7041.00
246_G280_Y0.7041.00
79_K255_L0.7031.00
54_V65_E0.7021.00
316_M323_G0.6991.00
183_T225_G0.6971.00
277_K281_K0.6951.00
284_L288_K0.6901.00
229_E233_V0.6891.00
123_Q234_A0.6851.00
143_D149_L0.6851.00
317_A344_R0.6851.00
295_P363_V0.6851.00
37_D41_E0.6821.00
29_A32_D0.6821.00
290_G293_A0.6811.00
272_E275_A0.6811.00
17_E20_R0.6811.00
265_Q268_N0.6781.00
358_N362_E0.6771.00
263_N361_G0.6751.00
312_Y336_I0.6741.00
204_G342_A0.6731.00
23_V42_W0.6711.00
161_H207_E0.6701.00
110_H222_N0.6701.00
356_L359_L0.6691.00
265_Q317_A0.6681.00
146_E221_E0.6671.00
205_R349_A0.6641.00
260_S269_T0.6631.00
352_T355_I0.6611.00
40_R162_L0.6611.00
171_R181_G0.6611.00
178_R181_G0.6591.00
153_Q197_S0.6581.00
308_I312_Y0.6571.00
145_G149_L0.6571.00
167_L224_V0.6561.00
172_T181_G0.6561.00
11_Y69_K0.6531.00
319_M336_I0.6521.00
279_F303_V0.6521.00
59_E64_G0.6501.00
280_Y304_A0.6441.00
169_L234_A0.6411.00
125_F134_L0.6411.00
12_R75_E0.6401.00
16_R79_K0.6381.00
321_I324_L0.6381.00
246_G304_A0.6361.00
162_L207_E0.6361.00
42_W45_R0.6361.00
56_W60_Y0.6351.00
253_E276_L0.6351.00
137_I171_R0.6351.00
247_T251_T0.6341.00
24_P27_I0.6331.00
220_K227_I0.6331.00
150_V187_V0.6311.00
114_I165_Y0.6301.00
157_S211_V0.6291.00
249_L305_S0.6271.00
328_R335_E0.6271.00
279_F283_I0.6261.00
143_D217_K0.6241.00
106_Q109_K0.6221.00
299_V360_L0.6201.00
139_T213_F0.6191.00
282_R296_E0.6161.00
70_E244_N0.6151.00
40_R120_V0.6151.00
110_H119_D0.6141.00
276_L303_V0.6121.00
11_Y73_V0.6121.00
102_G107_K0.6061.00
140_K174_D0.6031.00
255_L335_E0.5981.00
309_Q343_S0.5971.00
128_P153_Q0.5961.00
269_T318_N0.5951.00
272_E306_E0.5951.00
172_T227_I0.5941.00
274_V279_F0.5911.00
97_A101_N0.5871.00
139_T152_G0.5861.00
97_A237_T0.5841.00
194_I213_F0.5831.00
99_I107_K0.5811.00
168_L216_V0.5811.00
160_A211_V0.5791.00
140_K173_G0.5751.00
53_G115_L0.5741.00
243_L284_L0.5651.00
67_P287_L0.5631.00
302_L360_L0.5631.00
82_V252_V0.5621.00
305_S346_I0.5621.00
57_P62_G0.5611.00
335_E339_G0.5601.00
187_V213_F0.5581.00
239_N297_A0.5561.00
139_T170_T0.5551.00
335_E338_Y0.5511.00
158_S208_F0.5511.00
174_D177_E0.5511.00
165_Y222_N0.5511.00
196_V209_N0.5491.00
16_R80_A0.5481.00
199_I210_T0.5481.00
144_K220_K0.5481.00
95_G111_I0.5471.00
270_A364_V0.5461.00
243_L280_Y0.5431.00
27_I338_Y0.5431.00
86_T205_R0.5421.00
256_I260_S0.5411.00
125_F169_L0.5411.00
21_N25_E0.5401.00
268_N306_E0.5401.00
97_A233_V0.5401.00
46_I84_Y0.5391.00
185_L222_N0.5381.00
286_R289_K0.5361.00
23_V84_Y0.5361.00
89_L93_V0.5361.00
30_K81_G0.5351.00
139_T168_L0.5341.00
187_V216_V0.5341.00
302_L306_E0.5331.00
202_I208_F0.5321.00
30_K37_D0.5311.00
53_G63_W0.5301.00
254_R273_I0.5291.00
185_L220_K0.5281.00
271_E275_A0.5281.00
36_P39_L0.5251.00
26_E42_W0.5241.00
71_I281_K0.5231.00
130_A138_K0.5231.00
232_K236_S0.5231.00
238_L241_E0.5221.00
11_Y15_V0.5221.00
226_K233_V0.5221.00
173_G178_R0.5221.00
355_I358_N0.5221.00
14_K63_W0.5211.00
170_T183_T0.5211.00
60_Y112_R0.5191.00
28_R335_E0.5181.00
268_N271_E0.5171.00
276_L300_I0.5171.00
70_E92_S0.5151.00
328_R336_I0.5121.00
203_T341_L0.5121.00
94_V97_A0.5121.00
253_E308_I0.5111.00
269_T272_E0.5081.00
24_P80_A0.5071.00
190_K196_V0.5051.00
344_R348_I0.5051.00
36_P201_Q0.5041.00
120_V159_Y0.5031.00
266_L318_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jifA 4 0.9676 100 0.139 Contact Map
1ivhA 4 0.9703 100 0.14 Contact Map
4l1fA 4 0.9676 100 0.145 Contact Map
2d29A 4 0.973 100 0.145 Contact Map
4rm7A 4 0.9486 100 0.146 Contact Map
4p13A 4 0.9784 100 0.15 Contact Map
1rx0A 4 0.9649 100 0.151 Contact Map
3nf4A 4 0.9514 100 0.151 Contact Map
1ukwA 4 0.9676 100 0.151 Contact Map
4m9aA 4 0.9595 100 0.152 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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