GREMLIN Database
Q97VU4 - Uncharacterized protein
UniProt: Q97VU4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (251)
Sequences: 4344 (3284)
Seq/√Len: 207.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_T164_C4.5721.00
206_Q229_E4.0781.00
203_D232_K4.0591.00
243_M294_F3.9461.00
139_D204_K3.7671.00
58_V165_L3.3681.00
253_S256_N3.2421.00
31_I60_T3.1031.00
59_I70_V3.0711.00
27_E55_N2.9481.00
31_I172_F2.9061.00
152_V163_I2.7741.00
144_K149_Q2.7441.00
29_V56_F2.7251.00
142_V151_R2.6991.00
162_H174_G2.6151.00
246_I295_I2.5931.00
142_V149_Q2.5101.00
229_E233_E2.5061.00
288_Y292_E2.4891.00
223_D226_K2.4341.00
60_T174_G2.4081.00
206_Q232_K2.4051.00
43_T47_Y2.2361.00
152_V165_L2.1961.00
56_F82_S2.1331.00
56_F80_L2.0291.00
84_R154_L1.9141.00
82_S135_N1.8691.00
85_E138_K1.8561.00
155_T201_S1.8361.00
45_S76_K1.7251.00
170_V214_Y1.6941.00
194_P197_A1.6881.00
84_R163_I1.6701.00
80_L135_N1.6661.00
22_V31_I1.6561.00
240_E244_N1.6391.00
169_K211_E1.6081.00
33_T57_V1.5871.00
41_V72_L1.5551.00
203_D207_K1.5501.00
138_K141_D1.5471.00
176_H205_V1.5431.00
236_K240_E1.5401.00
139_D154_L1.5381.00
203_D236_K1.5351.00
155_T162_H1.5321.00
47_Y50_A1.5201.00
212_L222_K1.4811.00
82_S137_V1.4671.00
227_R231_I1.4631.00
74_K134_F1.4541.00
151_R208_L1.4531.00
173_C213_L1.4511.00
21_L30_L1.4261.00
166_V171_V1.4131.00
182_T231_I1.4051.00
46_N50_A1.4011.00
150_M167_Y1.3961.00
20_Y214_Y1.3951.00
171_V208_L1.3931.00
72_L76_K1.3861.00
252_T260_R1.3791.00
204_K207_K1.3761.00
20_Y216_A1.3681.00
199_L232_K1.3391.00
177_I228_V1.3241.00
45_S49_K1.3231.00
42_T46_N1.3151.00
209_D225_S1.2921.00
213_L224_V1.2801.00
20_Y172_F1.2801.00
287_K290_V1.2791.00
252_T256_N1.2781.00
135_N141_D1.2711.00
137_V152_V1.2571.00
215_P218_G1.2551.00
226_K230_E1.2081.00
206_Q225_S1.1981.00
202_L228_V1.1951.00
23_K28_S1.1811.00
148_E167_Y1.1781.00
46_N49_K1.1691.00
198_Y202_L1.1621.00
203_D206_Q1.1521.00
28_S53_Y1.1521.00
29_V58_V1.1521.00
166_V210_I1.1401.00
199_L203_D1.1351.00
22_V167_Y1.1311.00
242_I282_T1.1291.00
153_L166_V1.1261.00
200_E204_K1.1241.00
193_N288_Y1.1131.00
193_N196_K1.1061.00
83_D87_E1.0971.00
154_L163_I1.0961.00
157_G201_S1.0911.00
70_V81_I1.0851.00
151_R166_V1.0831.00
274_D277_L1.0781.00
87_E161_G1.0761.00
243_M247_R1.0761.00
67_M70_V1.0751.00
227_R230_E1.0721.00
233_E237_R1.0661.00
206_Q228_V1.0461.00
41_V69_L1.0401.00
58_V163_I1.0361.00
57_V79_I1.0291.00
27_E56_F1.0281.00
47_Y51_Y1.0191.00
177_I224_V1.0161.00
245_I261_I1.0041.00
194_P291_E1.0011.00
21_L28_S1.0001.00
145_L148_E0.9991.00
256_N259_S0.9981.00
66_H175_D0.9941.00
170_V212_L0.9901.00
176_H201_S0.9881.00
19_S30_L0.9861.00
196_K200_E0.9751.00
10_M13_P0.9691.00
232_K236_K0.9691.00
90_T93_L0.9661.00
22_V150_M0.9631.00
181_I185_I0.9631.00
49_K76_K0.9591.00
244_N247_R0.9520.99
85_E136_T0.9420.99
87_E159_T0.9400.99
150_M165_L0.9380.99
19_S33_T0.9320.99
144_K147_Q0.9300.99
30_L33_T0.9290.99
8_L19_S0.9230.99
255_F259_S0.9230.99
29_V150_M0.9110.99
88_Y92_L0.9100.99
80_L134_F0.9070.99
32_D61_H0.9040.99
19_S34_G0.9020.99
137_V143_I0.8970.99
36_P69_L0.8940.99
72_L75_D0.8900.99
261_I282_T0.8840.99
62_Y87_E0.8830.99
169_K209_D0.8820.99
255_F279_M0.8820.99
40_D43_T0.8750.99
26_E55_N0.8740.99
240_E243_M0.8540.99
140_G151_R0.8520.99
150_M172_F0.8460.99
213_L221_L0.8370.99
30_L73_F0.8310.99
23_K53_Y0.8310.99
164_C171_V0.8300.99
167_Y172_F0.8300.99
58_V150_M0.8290.99
84_R87_E0.8270.99
244_N248_T0.8250.99
166_V208_L0.8250.99
124_R127_E0.8240.98
70_V74_K0.8190.98
270_L275_K0.8120.98
200_E203_D0.8110.98
38_Q72_L0.8110.98
22_V148_E0.8060.98
68_G71_R0.8030.98
210_I213_L0.8020.98
257_I282_T0.7990.98
27_E54_P0.7980.98
173_C177_I0.7910.98
18_N218_G0.7890.98
42_T45_S0.7890.98
164_C205_V0.7880.98
233_E236_K0.7870.98
29_V55_N0.7860.98
195_L198_Y0.7860.98
194_P287_K0.7820.98
131_G134_F0.7820.98
257_I261_I0.7800.98
245_I260_R0.7770.98
173_C215_P0.7740.98
155_T176_H0.7710.98
61_H175_D0.7700.98
254_G258_A0.7670.98
231_I235_H0.7640.98
57_V73_F0.7640.98
256_N260_R0.7630.98
199_L236_K0.7580.97
196_K292_E0.7540.97
83_D91_Y0.7490.97
258_A261_I0.7480.97
196_K288_Y0.7430.97
8_L16_Y0.7400.97
234_H237_R0.7400.97
258_A282_T0.7390.97
156_P201_S0.7390.97
272_A275_K0.7360.97
228_V232_K0.7320.97
189_R280_G0.7300.97
242_I285_H0.7280.97
159_T162_H0.7240.97
29_V145_L0.7230.97
290_V296_R0.7220.97
241_E245_I0.7220.97
88_Y136_T0.7200.96
140_G154_L0.7170.96
234_H238_R0.7160.96
229_E232_K0.7160.96
198_Y238_R0.7150.96
19_S44_L0.7140.96
58_V82_S0.7110.96
17_I216_A0.7100.96
271_S274_D0.7090.96
245_I257_I0.7060.96
24_G147_Q0.7050.96
183_P231_I0.7030.96
182_T185_I0.7000.96
141_D152_V0.6990.96
137_V140_G0.6980.96
239_L288_Y0.6970.96
215_P221_L0.6950.96
164_C173_C0.6950.96
257_I260_R0.6940.96
18_N216_A0.6940.96
235_H285_H0.6910.96
59_I67_M0.6900.96
172_F214_Y0.6860.95
281_E284_A0.6850.95
221_L227_R0.6840.95
290_V295_I0.6840.95
171_V213_L0.6830.95
259_S275_K0.6810.95
209_D212_L0.6800.95
8_L13_P0.6790.95
85_E88_Y0.6750.95
242_I245_I0.6750.95
86_L89_V0.6750.95
245_I248_T0.6740.95
9_P43_T0.6730.95
197_A200_E0.6720.95
268_D275_K0.6690.95
94_S216_A0.6690.95
181_I184_N0.6670.95
55_N80_L0.6660.95
164_C176_H0.6650.95
235_H239_L0.6620.94
137_V163_I0.6620.94
140_G163_I0.6610.94
28_S52_G0.6600.94
248_T260_R0.6600.94
153_L164_C0.6590.94
166_V169_K0.6560.94
176_H198_Y0.6460.94
254_G283_L0.6430.94
270_L273_F0.6420.93
255_F258_A0.6400.93
210_I261_I0.6400.93
285_H288_Y0.6390.93
87_E90_T0.6370.93
148_E168_E0.6370.93
49_K52_G0.6310.93
43_T46_N0.6290.93
234_H285_H0.6290.93
231_I234_H0.6270.93
10_M14_L0.6260.93
137_V165_L0.6260.93
32_D175_D0.6250.93
162_H190_L0.6250.93
254_G286_I0.6240.93
149_Q168_E0.6230.92
44_L69_L0.6210.92
248_T251_K0.6210.92
13_P16_Y0.6210.92
25_N28_S0.6200.92
196_K291_E0.6180.92
44_L48_L0.6140.92
91_Y94_S0.6140.92
275_K279_M0.6130.92
201_S204_K0.6110.92
185_I284_A0.6070.91
212_L220_V0.6070.91
290_V293_G0.6070.91
71_R75_D0.6060.91
273_F277_L0.6060.91
31_I165_L0.6050.91
36_P41_V0.6030.91
178_L183_P0.6010.91
83_D86_L0.6010.91
62_Y67_M0.6000.91
246_I251_K0.5990.91
164_C201_S0.5980.91
8_L17_I0.5960.91
247_R296_R0.5960.91
184_N281_E0.5950.91
239_L243_M0.5950.91
85_E89_V0.5920.90
32_D216_A0.5900.90
33_T70_V0.5890.90
211_E223_D0.5890.90
227_R235_H0.5880.90
28_S48_L0.5880.90
41_V45_S0.5880.90
225_S229_E0.5870.90
90_T94_S0.5870.90
162_H176_H0.5870.90
278_A285_H0.5850.90
177_I231_I0.5820.90
89_V92_L0.5800.90
259_S272_A0.5800.90
182_T285_H0.5780.89
248_T252_T0.5770.89
238_R241_E0.5750.89
56_F135_N0.5750.89
38_Q42_T0.5740.89
198_Y235_H0.5740.89
179_Q221_L0.5730.89
63_H159_T0.5720.89
281_E285_H0.5680.89
35_L67_M0.5680.89
88_Y91_Y0.5640.88
224_V228_V0.5640.88
167_Y170_V0.5620.88
86_L91_Y0.5600.88
280_G284_A0.5600.88
267_W270_L0.5590.88
242_I257_I0.5580.88
57_V74_K0.5570.88
178_L181_I0.5560.87
182_T234_H0.5520.87
10_M17_I0.5480.87
21_L47_Y0.5480.87
74_K81_I0.5430.86
17_I174_G0.5430.86
252_T257_I0.5410.86
280_G283_L0.5410.86
157_G162_H0.5400.86
176_H183_P0.5380.86
8_L12_G0.5350.85
286_I295_I0.5340.85
32_D215_P0.5330.85
254_G279_M0.5290.85
37_T42_T0.5290.85
247_R250_G0.5260.84
277_L281_E0.5240.84
85_E91_Y0.5230.84
34_G198_Y0.5230.84
62_Y159_T0.5220.84
34_G157_G0.5210.84
10_M19_S0.5210.84
62_Y161_G0.5200.84
162_H216_A0.5190.84
157_G185_I0.5190.84
25_N147_Q0.5190.84
198_Y234_H0.5180.84
82_S87_E0.5170.83
288_Y291_E0.5160.83
178_L238_R0.5160.83
199_L288_Y0.5160.83
175_D217_H0.5140.83
75_D78_I0.5120.83
154_L204_K0.5100.83
193_N291_E0.5090.83
238_R242_I0.5060.82
185_I199_L0.5040.82
84_R89_V0.5030.82
23_K27_E0.5020.82
84_R90_T0.5020.82
199_L239_L0.5010.82
10_M16_Y0.5010.82
180_D219_E0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zo4A 1 0.9226 100 0.275 Contact Map
4ad9A 4 0.8516 100 0.376 Contact Map
2yheA 3 0.9903 100 0.452 Contact Map
2cfuA 2 0.9742 100 0.457 Contact Map
4pdxA 2 0.9774 100 0.466 Contact Map
4nurA 2 0.9871 100 0.475 Contact Map
2vw8A 2 0.8968 100 0.483 Contact Map
2p18A 1 0.7645 100 0.483 Contact Map
1qh5A 1 0.7774 100 0.492 Contact Map
2fhxA 2 0.7194 100 0.497 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.