Q97VU4 - SULSO - GREMLIN Contacts

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Q97VU4 - Uncharacterized protein

UniProt:	Q97VU4	Sequences: MTIFTLKLPMQGPLKYINSYLVKGNEESVLIDTGLPTQEDVTTLSNYLKAYGYPNFVVITHYHPDHMGLVRLFKDKSIILISDRELEYVTYLLSEEYEKEMRKYLLANGFPEEFIQRMFRNRSRFSEIIDGVNFNTVKDGDVIKLGQEQMRVLLTPGHTMGHICLVYEKVVFCGDHILQDITPNISLLRLEDNPLKAYLESLDKVQKLDIELLYPAHGEVLKDVSKRVEEIKEHHKRRLEEIMNIIRTLGKTSGFNIASRISWYKKWDELSAFDKQLAMGETLAHIKYLVEEGFIREVNASGSIYYTMSS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	310 (251)
Sequences:	4344 (3284)
Seq/√Len:	207.3

ECOLI - GLO2 YCBL
BACSU - YQJP PKSB YYBB YQGX YOBT YFLN
HALSA - Q9HRG5 Q9HNJ9 Q9HSD1 Q9HNJ2 Q9HQ50 Q9HSH2
SULSO - Q97VU4 Q97WC2 Q97VU0 Q97UV2 Q7LYK3 Q97U88 Q97XZ1 Q97YZ2 Q97UR2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
155_T	164_C	4.572	1.00
206_Q	229_E	4.078	1.00
203_D	232_K	4.059	1.00
243_M	294_F	3.946	1.00
139_D	204_K	3.767	1.00
58_V	165_L	3.368	1.00
253_S	256_N	3.242	1.00
31_I	60_T	3.103	1.00
59_I	70_V	3.071	1.00
27_E	55_N	2.948	1.00
31_I	172_F	2.906	1.00
152_V	163_I	2.774	1.00
144_K	149_Q	2.744	1.00
29_V	56_F	2.725	1.00
142_V	151_R	2.699	1.00
162_H	174_G	2.615	1.00
246_I	295_I	2.593	1.00
142_V	149_Q	2.510	1.00
229_E	233_E	2.506	1.00
288_Y	292_E	2.489	1.00
223_D	226_K	2.434	1.00
60_T	174_G	2.408	1.00
206_Q	232_K	2.405	1.00
43_T	47_Y	2.236	1.00
152_V	165_L	2.196	1.00
56_F	82_S	2.133	1.00
56_F	80_L	2.029	1.00
84_R	154_L	1.914	1.00
82_S	135_N	1.869	1.00
85_E	138_K	1.856	1.00
155_T	201_S	1.836	1.00
45_S	76_K	1.725	1.00
170_V	214_Y	1.694	1.00
194_P	197_A	1.688	1.00
84_R	163_I	1.670	1.00
80_L	135_N	1.666	1.00
22_V	31_I	1.656	1.00
240_E	244_N	1.639	1.00
169_K	211_E	1.608	1.00
33_T	57_V	1.587	1.00
41_V	72_L	1.555	1.00
203_D	207_K	1.550	1.00
138_K	141_D	1.547	1.00
176_H	205_V	1.543	1.00
236_K	240_E	1.540	1.00
139_D	154_L	1.538	1.00
203_D	236_K	1.535	1.00
155_T	162_H	1.532	1.00
47_Y	50_A	1.520	1.00
212_L	222_K	1.481	1.00
82_S	137_V	1.467	1.00
227_R	231_I	1.463	1.00
74_K	134_F	1.454	1.00
151_R	208_L	1.453	1.00
173_C	213_L	1.451	1.00
21_L	30_L	1.426	1.00
166_V	171_V	1.413	1.00
182_T	231_I	1.405	1.00
46_N	50_A	1.401	1.00
150_M	167_Y	1.396	1.00
20_Y	214_Y	1.395	1.00
171_V	208_L	1.393	1.00
72_L	76_K	1.386	1.00
252_T	260_R	1.379	1.00
204_K	207_K	1.376	1.00
20_Y	216_A	1.368	1.00
199_L	232_K	1.339	1.00
177_I	228_V	1.324	1.00
45_S	49_K	1.323	1.00
42_T	46_N	1.315	1.00
209_D	225_S	1.292	1.00
213_L	224_V	1.280	1.00
20_Y	172_F	1.280	1.00
287_K	290_V	1.279	1.00
252_T	256_N	1.278	1.00
135_N	141_D	1.271	1.00
137_V	152_V	1.257	1.00
215_P	218_G	1.255	1.00
226_K	230_E	1.208	1.00
206_Q	225_S	1.198	1.00
202_L	228_V	1.195	1.00
23_K	28_S	1.181	1.00
148_E	167_Y	1.178	1.00
46_N	49_K	1.169	1.00
198_Y	202_L	1.162	1.00
203_D	206_Q	1.152	1.00
28_S	53_Y	1.152	1.00
29_V	58_V	1.152	1.00
166_V	210_I	1.140	1.00
199_L	203_D	1.135	1.00
22_V	167_Y	1.131	1.00
242_I	282_T	1.129	1.00
153_L	166_V	1.126	1.00
200_E	204_K	1.124	1.00
193_N	288_Y	1.113	1.00
193_N	196_K	1.106	1.00
83_D	87_E	1.097	1.00
154_L	163_I	1.096	1.00
157_G	201_S	1.091	1.00
70_V	81_I	1.085	1.00
151_R	166_V	1.083	1.00
274_D	277_L	1.078	1.00
87_E	161_G	1.076	1.00
243_M	247_R	1.076	1.00
67_M	70_V	1.075	1.00
227_R	230_E	1.072	1.00
233_E	237_R	1.066	1.00
206_Q	228_V	1.046	1.00
41_V	69_L	1.040	1.00
58_V	163_I	1.036	1.00
57_V	79_I	1.029	1.00
27_E	56_F	1.028	1.00
47_Y	51_Y	1.019	1.00
177_I	224_V	1.016	1.00
245_I	261_I	1.004	1.00
194_P	291_E	1.001	1.00
21_L	28_S	1.000	1.00
145_L	148_E	0.999	1.00
256_N	259_S	0.998	1.00
66_H	175_D	0.994	1.00
170_V	212_L	0.990	1.00
176_H	201_S	0.988	1.00
19_S	30_L	0.986	1.00
196_K	200_E	0.975	1.00
10_M	13_P	0.969	1.00
232_K	236_K	0.969	1.00
90_T	93_L	0.966	1.00
22_V	150_M	0.963	1.00
181_I	185_I	0.963	1.00
49_K	76_K	0.959	1.00
244_N	247_R	0.952	0.99
85_E	136_T	0.942	0.99
87_E	159_T	0.940	0.99
150_M	165_L	0.938	0.99
19_S	33_T	0.932	0.99
144_K	147_Q	0.930	0.99
30_L	33_T	0.929	0.99
8_L	19_S	0.923	0.99
255_F	259_S	0.923	0.99
29_V	150_M	0.911	0.99
88_Y	92_L	0.910	0.99
80_L	134_F	0.907	0.99
32_D	61_H	0.904	0.99
19_S	34_G	0.902	0.99
137_V	143_I	0.897	0.99
36_P	69_L	0.894	0.99
72_L	75_D	0.890	0.99
261_I	282_T	0.884	0.99
62_Y	87_E	0.883	0.99
169_K	209_D	0.882	0.99
255_F	279_M	0.882	0.99
40_D	43_T	0.875	0.99
26_E	55_N	0.874	0.99
240_E	243_M	0.854	0.99
140_G	151_R	0.852	0.99
150_M	172_F	0.846	0.99
213_L	221_L	0.837	0.99
30_L	73_F	0.831	0.99
23_K	53_Y	0.831	0.99
164_C	171_V	0.830	0.99
167_Y	172_F	0.830	0.99
58_V	150_M	0.829	0.99
84_R	87_E	0.827	0.99
244_N	248_T	0.825	0.99
166_V	208_L	0.825	0.99
124_R	127_E	0.824	0.98
70_V	74_K	0.819	0.98
270_L	275_K	0.812	0.98
200_E	203_D	0.811	0.98
38_Q	72_L	0.811	0.98
22_V	148_E	0.806	0.98
68_G	71_R	0.803	0.98
210_I	213_L	0.802	0.98
257_I	282_T	0.799	0.98
27_E	54_P	0.798	0.98
173_C	177_I	0.791	0.98
18_N	218_G	0.789	0.98
42_T	45_S	0.789	0.98
164_C	205_V	0.788	0.98
233_E	236_K	0.787	0.98
29_V	55_N	0.786	0.98
195_L	198_Y	0.786	0.98
194_P	287_K	0.782	0.98
131_G	134_F	0.782	0.98
257_I	261_I	0.780	0.98
245_I	260_R	0.777	0.98
173_C	215_P	0.774	0.98
155_T	176_H	0.771	0.98
61_H	175_D	0.770	0.98
254_G	258_A	0.767	0.98
231_I	235_H	0.764	0.98
57_V	73_F	0.764	0.98
256_N	260_R	0.763	0.98
199_L	236_K	0.758	0.97
196_K	292_E	0.754	0.97
83_D	91_Y	0.749	0.97
258_A	261_I	0.748	0.97
196_K	288_Y	0.743	0.97
8_L	16_Y	0.740	0.97
234_H	237_R	0.740	0.97
258_A	282_T	0.739	0.97
156_P	201_S	0.739	0.97
272_A	275_K	0.736	0.97
228_V	232_K	0.732	0.97
189_R	280_G	0.730	0.97
242_I	285_H	0.728	0.97
159_T	162_H	0.724	0.97
29_V	145_L	0.723	0.97
290_V	296_R	0.722	0.97
241_E	245_I	0.722	0.97
88_Y	136_T	0.720	0.96
140_G	154_L	0.717	0.96
234_H	238_R	0.716	0.96
229_E	232_K	0.716	0.96
198_Y	238_R	0.715	0.96
19_S	44_L	0.714	0.96
58_V	82_S	0.711	0.96
17_I	216_A	0.710	0.96
271_S	274_D	0.709	0.96
245_I	257_I	0.706	0.96
24_G	147_Q	0.705	0.96
183_P	231_I	0.703	0.96
182_T	185_I	0.700	0.96
141_D	152_V	0.699	0.96
137_V	140_G	0.698	0.96
239_L	288_Y	0.697	0.96
215_P	221_L	0.695	0.96
164_C	173_C	0.695	0.96
257_I	260_R	0.694	0.96
18_N	216_A	0.694	0.96
235_H	285_H	0.691	0.96
59_I	67_M	0.690	0.96
172_F	214_Y	0.686	0.95
281_E	284_A	0.685	0.95
221_L	227_R	0.684	0.95
290_V	295_I	0.684	0.95
171_V	213_L	0.683	0.95
259_S	275_K	0.681	0.95
209_D	212_L	0.680	0.95
8_L	13_P	0.679	0.95
85_E	88_Y	0.675	0.95
242_I	245_I	0.675	0.95
86_L	89_V	0.675	0.95
245_I	248_T	0.674	0.95
9_P	43_T	0.673	0.95
197_A	200_E	0.672	0.95
268_D	275_K	0.669	0.95
94_S	216_A	0.669	0.95
181_I	184_N	0.667	0.95
55_N	80_L	0.666	0.95
164_C	176_H	0.665	0.95
235_H	239_L	0.662	0.94
137_V	163_I	0.662	0.94
140_G	163_I	0.661	0.94
28_S	52_G	0.660	0.94
248_T	260_R	0.660	0.94
153_L	164_C	0.659	0.94
166_V	169_K	0.656	0.94
176_H	198_Y	0.646	0.94
254_G	283_L	0.643	0.94
270_L	273_F	0.642	0.93
255_F	258_A	0.640	0.93
210_I	261_I	0.640	0.93
285_H	288_Y	0.639	0.93
87_E	90_T	0.637	0.93
148_E	168_E	0.637	0.93
49_K	52_G	0.631	0.93
43_T	46_N	0.629	0.93
234_H	285_H	0.629	0.93
231_I	234_H	0.627	0.93
10_M	14_L	0.626	0.93
137_V	165_L	0.626	0.93
32_D	175_D	0.625	0.93
162_H	190_L	0.625	0.93
254_G	286_I	0.624	0.93
149_Q	168_E	0.623	0.92
44_L	69_L	0.621	0.92
248_T	251_K	0.621	0.92
13_P	16_Y	0.621	0.92
25_N	28_S	0.620	0.92
196_K	291_E	0.618	0.92
44_L	48_L	0.614	0.92
91_Y	94_S	0.614	0.92
275_K	279_M	0.613	0.92
201_S	204_K	0.611	0.92
185_I	284_A	0.607	0.91
212_L	220_V	0.607	0.91
290_V	293_G	0.607	0.91
71_R	75_D	0.606	0.91
273_F	277_L	0.606	0.91
31_I	165_L	0.605	0.91
36_P	41_V	0.603	0.91
178_L	183_P	0.601	0.91
83_D	86_L	0.601	0.91
62_Y	67_M	0.600	0.91
246_I	251_K	0.599	0.91
164_C	201_S	0.598	0.91
8_L	17_I	0.596	0.91
247_R	296_R	0.596	0.91
184_N	281_E	0.595	0.91
239_L	243_M	0.595	0.91
85_E	89_V	0.592	0.90
32_D	216_A	0.590	0.90
33_T	70_V	0.589	0.90
211_E	223_D	0.589	0.90
227_R	235_H	0.588	0.90
28_S	48_L	0.588	0.90
41_V	45_S	0.588	0.90
225_S	229_E	0.587	0.90
90_T	94_S	0.587	0.90
162_H	176_H	0.587	0.90
278_A	285_H	0.585	0.90
177_I	231_I	0.582	0.90
89_V	92_L	0.580	0.90
259_S	272_A	0.580	0.90
182_T	285_H	0.578	0.89
248_T	252_T	0.577	0.89
238_R	241_E	0.575	0.89
56_F	135_N	0.575	0.89
38_Q	42_T	0.574	0.89
198_Y	235_H	0.574	0.89
179_Q	221_L	0.573	0.89
63_H	159_T	0.572	0.89
281_E	285_H	0.568	0.89
35_L	67_M	0.568	0.89
88_Y	91_Y	0.564	0.88
224_V	228_V	0.564	0.88
167_Y	170_V	0.562	0.88
86_L	91_Y	0.560	0.88
280_G	284_A	0.560	0.88
267_W	270_L	0.559	0.88
242_I	257_I	0.558	0.88
57_V	74_K	0.557	0.88
178_L	181_I	0.556	0.87
182_T	234_H	0.552	0.87
10_M	17_I	0.548	0.87
21_L	47_Y	0.548	0.87
74_K	81_I	0.543	0.86
17_I	174_G	0.543	0.86
252_T	257_I	0.541	0.86
280_G	283_L	0.541	0.86
157_G	162_H	0.540	0.86
176_H	183_P	0.538	0.86
8_L	12_G	0.535	0.85
286_I	295_I	0.534	0.85
32_D	215_P	0.533	0.85
254_G	279_M	0.529	0.85
37_T	42_T	0.529	0.85
247_R	250_G	0.526	0.84
277_L	281_E	0.524	0.84
85_E	91_Y	0.523	0.84
34_G	198_Y	0.523	0.84
62_Y	159_T	0.522	0.84
34_G	157_G	0.521	0.84
10_M	19_S	0.521	0.84
62_Y	161_G	0.520	0.84
162_H	216_A	0.519	0.84
157_G	185_I	0.519	0.84
25_N	147_Q	0.519	0.84
198_Y	234_H	0.518	0.84
82_S	87_E	0.517	0.83
288_Y	291_E	0.516	0.83
178_L	238_R	0.516	0.83
199_L	288_Y	0.516	0.83
175_D	217_H	0.514	0.83
75_D	78_I	0.512	0.83
154_L	204_K	0.510	0.83
193_N	291_E	0.509	0.83
238_R	242_I	0.506	0.82
185_I	199_L	0.504	0.82
84_R	89_V	0.503	0.82
23_K	27_E	0.502	0.82
84_R	90_T	0.502	0.82
199_L	239_L	0.501	0.82
10_M	16_Y	0.501	0.82
180_D	219_E	0.500	0.81

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2zo4A	1	0.9226	100	0.275	Contact Map
4ad9A	4	0.8516	100	0.376	Contact Map
2yheA	3	0.9903	100	0.452	Contact Map
2cfuA	2	0.9742	100	0.457	Contact Map
4pdxA	2	0.9774	100	0.466	Contact Map
4nurA	2	0.9871	100	0.475	Contact Map
2vw8A	2	0.8968	100	0.483	Contact Map
2p18A	1	0.7645	100	0.483	Contact Map
1qh5A	1	0.7774	100	0.492	Contact Map
2fhxA	2	0.7194	100	0.497	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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