GREMLIN Database
Q97VU2 - Carboxylesterase (Est)
UniProt: Q97VU2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (231)
Sequences: 15818 (12282)
Seq/√Len: 808.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_R71_D4.8731.00
24_F72_C3.7131.00
94_A121_A3.1671.00
21_I96_F3.0821.00
29_W103_N2.7501.00
204_A214_T2.6941.00
82_N85_S2.5991.00
207_L212_V2.5611.00
201_E218_R2.5501.00
20_I88_G2.5461.00
109_S122_Q2.4771.00
63_H67_A2.4611.00
34_I56_N2.3491.00
22_L75_S2.3291.00
204_A216_S2.2791.00
76_I119_L2.2401.00
53_I79_T2.2131.00
78_W82_N2.1961.00
186_A207_L2.0131.00
55_V75_S2.0111.00
204_A208_M1.9781.00
188_I204_A1.9461.00
37_E98_I1.9291.00
72_C108_T1.9281.00
73_F111_L1.9191.00
20_I53_I1.8921.00
201_E216_S1.8871.00
124_L127_P1.8851.00
122_Q186_A1.8801.00
190_T200_G1.8621.00
23_H96_F1.8611.00
89_H92_R1.8481.00
106_A203_Y1.8431.00
111_L115_Q1.7741.00
57_Y100_A1.7591.00
205_K209_E1.7411.00
38_D42_R1.7251.00
9_I53_I1.7151.00
95_V105_A1.6881.00
208_M214_T1.6771.00
192_E220_N1.6531.00
11_Y51_I1.6421.00
51_I88_G1.6391.00
22_L76_I1.6361.00
187_I217_F1.6131.00
18_H51_I1.5821.00
20_I79_T1.5811.00
73_F112_S1.5471.00
43_I47_S1.5461.00
24_F55_V1.5001.00
69_V107_A1.4891.00
70_T111_L1.4831.00
22_L79_T1.4741.00
41_S52_V1.4601.00
111_L171_M1.4531.00
21_I50_C1.4461.00
96_F123_A1.4151.00
137_S198_D1.4101.00
206_R210_A1.3931.00
47_S241_G1.3921.00
45_A52_V1.3871.00
206_R209_E1.3781.00
122_Q203_Y1.3771.00
155_Y159_M1.3761.00
106_A124_L1.3751.00
190_T218_R1.3661.00
76_I108_T1.3631.00
72_C104_L1.3441.00
190_T216_S1.3201.00
73_F77_K1.3111.00
126_V225_G1.3001.00
29_W128_F1.2911.00
188_I200_G1.2881.00
19_P92_R1.2751.00
25_H59_L1.2731.00
20_I51_I1.2691.00
121_A187_I1.2671.00
113_R182_N1.2511.00
18_H49_N1.2251.00
41_S54_S1.1961.00
180_L183_L1.1941.00
202_A205_K1.1941.00
23_H37_E1.1891.00
67_A71_D1.1871.00
197_R201_E1.1861.00
145_Y148_D1.1791.00
192_E218_R1.1621.00
41_S45_A1.1611.00
83_A88_G1.1521.00
95_V108_T1.1501.00
173_V176_I1.1341.00
76_I80_Y1.1311.00
65_F160_Y1.1301.00
77_K81_E1.1271.00
58_R67_A1.1221.00
19_P50_C1.1141.00
198_D201_E1.1061.00
58_R63_H1.1051.00
207_L214_T1.1031.00
77_K117_I1.1021.00
219_V226_F1.1021.00
24_F105_A1.0941.00
103_N107_A1.0841.00
140_E197_R1.0761.00
9_I51_I1.0751.00
114_D171_M1.0741.00
205_K208_M1.0661.00
126_V227_L1.0651.00
185_Q213_L1.0601.00
27_G32_G1.0461.00
73_F115_Q1.0281.00
197_R218_R1.0261.00
144_G148_D1.0221.00
174_P177_A1.0181.00
235_L238_V1.0141.00
189_V217_F1.0081.00
83_A86_I1.0071.00
92_R120_R0.9951.00
17_D89_H0.9951.00
60_A63_H0.9921.00
29_W100_A0.9821.00
23_H41_S0.9691.00
106_A129_V0.9681.00
189_V239_M0.9651.00
219_V222_M0.9571.00
110_I177_A0.9551.00
12_P18_H0.9431.00
105_A124_L0.9421.00
21_I94_A0.9421.00
129_V203_Y0.9311.00
222_M235_L0.9261.00
191_A226_F0.9211.00
73_F108_T0.9171.00
136_T140_E0.9131.00
77_K115_Q0.9121.00
132_D176_I0.9101.00
15_K18_H0.9091.00
149_I154_D0.9061.00
226_F239_M0.9031.00
65_F172_F0.8911.00
68_A104_L0.8851.00
152_P156_G0.8821.00
80_Y93_I0.8801.00
74_D77_K0.8761.00
188_I203_Y0.8701.00
111_L114_D0.8681.00
233_S236_V0.8651.00
190_T197_R0.8641.00
106_A186_A0.8631.00
166_D169_N0.8631.00
222_M226_F0.8521.00
98_I126_V0.8521.00
131_L173_V0.8501.00
60_A68_A0.8501.00
24_F108_T0.8471.00
76_I112_S0.8431.00
37_E40_V0.8391.00
192_E221_G0.8351.00
202_A206_R0.8341.00
83_A90_P0.8331.00
64_K67_A0.8301.00
219_V239_M0.8261.00
23_H98_I0.8261.00
109_S119_L0.8241.00
68_A160_Y0.8221.00
69_V111_L0.8191.00
110_I171_M0.8181.00
124_L129_V0.8151.00
43_I46_N0.8131.00
124_L188_I0.8111.00
103_N160_Y0.8071.00
20_I93_I0.8041.00
11_Y18_H0.8041.00
78_W86_I0.7971.00
64_K68_A0.7961.00
189_V219_V0.7901.00
23_H54_S0.7861.00
82_N86_I0.7811.00
126_V194_D0.7781.00
106_A122_Q0.7751.00
137_S141_Y0.7681.00
110_I183_L0.7671.00
33_S36_T0.7631.00
161_I172_F0.7621.00
238_V241_G0.7611.00
19_P89_H0.7601.00
65_F68_A0.7591.00
189_V227_L0.7581.00
68_A71_D0.7541.00
60_A66_P0.7511.00
25_H32_G0.7501.00
66_P70_T0.7481.00
65_F169_N0.7471.00
168_L176_I0.7451.00
139_T142_R0.7441.00
173_V177_A0.7441.00
24_F95_V0.7431.00
17_D84_E0.7401.00
137_S140_E0.7391.00
203_Y207_L0.7381.00
231_N237_S0.7371.00
30_I60_A0.7361.00
125_V227_L0.7301.00
128_F131_L0.7211.00
75_S78_W0.7191.00
225_G228_G0.7171.00
186_A203_Y0.7091.00
22_L108_T0.7061.00
105_A122_Q0.7051.00
100_A104_L0.7031.00
179_D210_A0.7001.00
10_Y38_D0.6981.00
99_S224_H0.6961.00
42_R46_N0.6901.00
131_L157_I0.6901.00
183_L186_A0.6891.00
96_F125_V0.6881.00
90_P93_I0.6861.00
193_Y221_G0.6821.00
168_L173_V0.6821.00
53_I78_W0.6821.00
130_Y133_L0.6761.00
154_D158_M0.6731.00
40_V44_L0.6721.00
219_V227_L0.6711.00
67_A70_T0.6711.00
31_L156_G0.6711.00
176_I179_D0.6671.00
190_T201_E0.6641.00
236_V240_V0.6611.00
130_Y173_V0.6601.00
201_E205_K0.6601.00
55_V72_C0.6601.00
122_Q184_P0.6591.00
30_I159_M0.6581.00
64_K162_R0.6571.00
98_I227_L0.6571.00
80_Y90_P0.6571.00
138_M199_Q0.6561.00
84_E90_P0.6561.00
18_H87_G0.6551.00
69_V108_T0.6541.00
153_I156_G0.6521.00
130_Y176_I0.6521.00
128_F157_I0.6521.00
135_S202_A0.6501.00
23_H52_V0.6471.00
28_A156_G0.6451.00
14_N18_H0.6451.00
237_S241_G0.6441.00
83_A87_G0.6431.00
102_G129_V0.6421.00
109_S186_A0.6391.00
107_A171_M0.6391.00
33_S59_L0.6341.00
22_L55_V0.6321.00
110_I180_L0.6321.00
162_R166_D0.6311.00
20_I83_A0.6301.00
110_I203_Y0.6291.00
17_D87_G0.6291.00
56_N59_L0.6271.00
34_I54_S0.6251.00
187_I215_L0.6241.00
32_G36_T0.6191.00
65_F171_M0.6191.00
170_P176_I0.6181.00
145_Y149_I0.6181.00
63_H68_A0.6141.00
133_L138_M0.6121.00
191_A222_M0.6101.00
50_C96_F0.6091.00
133_L154_D0.6081.00
33_S56_N0.6081.00
18_H92_R0.6061.00
139_T149_I0.6051.00
136_T139_T0.6041.00
110_I113_R0.6031.00
230_P233_S0.6021.00
161_I167_L0.6021.00
40_V227_L0.6001.00
130_Y199_Q0.5991.00
31_L36_T0.5981.00
12_P51_I0.5941.00
174_P178_E0.5941.00
44_L48_C0.5931.00
128_F153_I0.5931.00
24_F76_I0.5911.00
34_I41_S0.5891.00
95_V122_Q0.5851.00
195_P223_V0.5841.00
148_D152_P0.5841.00
125_V189_V0.5781.00
112_S117_I0.5761.00
29_W104_L0.5761.00
227_L239_M0.5751.00
174_P179_D0.5751.00
208_M216_S0.5741.00
180_L206_R0.5721.00
98_I125_V0.5711.00
158_M162_R0.5701.00
47_S240_V0.5681.00
10_Y34_I0.5661.00
162_R167_L0.5641.00
102_G127_P0.5631.00
119_L124_L0.5611.00
70_T74_D0.5611.00
188_I214_T0.5581.00
79_T88_G0.5581.00
141_Y144_G0.5581.00
145_Y193_Y0.5581.00
168_L171_M0.5561.00
105_A109_S0.5551.00
103_N128_F0.5531.00
153_I157_I0.5521.00
32_G59_L0.5511.00
98_I225_G0.5511.00
53_I75_S0.5501.00
142_R149_I0.5491.00
189_V226_F0.5481.00
194_D197_R0.5441.00
170_P177_A0.5421.00
198_D202_A0.5391.00
122_Q183_L0.5381.00
28_A99_S0.5371.00
29_W68_A0.5301.00
199_Q202_A0.5291.00
145_Y150_N0.5271.00
130_Y202_A0.5271.00
170_P178_E0.5231.00
200_G204_A0.5191.00
157_I162_R0.5181.00
21_I52_V0.5161.00
127_P200_G0.5161.00
135_S138_M0.5151.00
109_S183_L0.5131.00
165_K169_N0.5101.00
69_V104_L0.5101.00
80_Y120_R0.5071.00
121_A185_Q0.5071.00
28_A100_A0.5041.00
10_Y41_S0.5041.00
76_I93_I0.5021.00
164_E167_L0.5021.00
172_F176_I0.5021.00
226_F236_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wy8A 2 0.992 100 0.323 Contact Map
1lzlA 1 0.992 100 0.337 Contact Map
2hm7A 2 0.996 100 0.339 Contact Map
3wj1A 4 0.988 100 0.351 Contact Map
3zwqA 4 0.988 100 0.352 Contact Map
2c7bA 3 0.988 100 0.352 Contact Map
2o7rA 1 0.9681 100 0.36 Contact Map
4ob7A 2 0.996 100 0.38 Contact Map
4n5hX 3 0.9602 100 0.392 Contact Map
4wy5A 2 0.996 100 0.397 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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