GREMLIN Database
Q97VU0 - Cyclase/dehydrase, putative
UniProt: Q97VU0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (267)
Sequences: 5644 (4259)
Seq/√Len: 260.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
197_E225_R4.2461.00
200_A222_Y3.7941.00
146_K164_P3.7711.00
167_K205_E3.2351.00
70_N81_N3.2091.00
41_V71_T3.1711.00
9_R12_D2.8631.00
244_D247_R2.7321.00
136_R144_E2.7201.00
37_Y66_K2.6241.00
200_A225_R2.5981.00
236_R278_K2.5841.00
93_K132_K2.5551.00
163_I166_Q2.5551.00
69_I161_V2.5371.00
138_F144_E2.4811.00
133_D198_N2.4351.00
144_E165_D2.3441.00
136_R146_K2.2961.00
168_V208_I2.2931.00
88_I129_V2.2861.00
158_D172_G2.2221.00
67_Y90_I2.1321.00
67_Y88_I2.1251.00
143_E166_Q2.0791.00
41_V170_F2.0251.00
71_T172_G1.9941.00
39_V67_Y1.9851.00
30_G170_F1.9251.00
151_G160_Y1.8941.00
239_M279_G1.8901.00
147_I159_I1.8871.00
92_H149_Y1.7971.00
222_Y226_D1.7911.00
9_R13_N1.7891.00
90_I129_V1.7601.00
188_Y191_G1.7481.00
197_E229_I1.7351.00
43_S68_L1.6821.00
272_R276_E1.6751.00
257_Y260_W1.6541.00
92_H159_I1.6531.00
198_N201_N1.6401.00
54_I58_K1.6291.00
51_R55_S1.5971.00
55_S59_K1.5951.00
197_E201_N1.5931.00
56_E59_K1.5801.00
147_I161_V1.5781.00
206_I216_Y1.5541.00
193_I225_R1.5351.00
131_I159_I1.5031.00
151_G195_A1.5031.00
171_T207_F1.4961.00
145_I163_I1.4921.00
200_A218_R1.4851.00
50_A83_L1.4821.00
229_I233_D1.4741.00
196_L221_L1.4671.00
33_I63_K1.4561.00
31_V38_A1.4391.00
33_I38_A1.4391.00
167_K203_D1.4311.00
193_I229_I1.4131.00
169_V202_L1.3811.00
203_D218_R1.3781.00
168_V206_I1.3761.00
32_I41_V1.3731.00
162_Y169_V1.3701.00
13_N166_Q1.3701.00
91_C95_C1.3651.00
146_K202_L1.3601.00
243_S251_E1.3591.00
245_P249_A1.3531.00
41_V161_V1.3421.00
132_K135_M1.3281.00
39_V69_I1.3161.00
129_V135_M1.3141.00
261_I264_E1.3081.00
162_Y167_K1.3071.00
145_I161_V1.3001.00
57_I61_T1.2991.00
151_G158_D1.2941.00
39_V145_I1.2821.00
37_Y64_P1.2691.00
238_I243_S1.2691.00
175_L221_L1.2561.00
134_E146_K1.2521.00
225_R229_I1.2401.00
52_Q56_E1.2381.00
153_A195_A1.2301.00
133_D149_Y1.2291.00
162_Y204_A1.2221.00
209_P212_G1.2211.00
197_E200_A1.2201.00
31_V40_V1.2171.00
199_L202_L1.2101.00
71_T161_V1.2031.00
31_V57_I1.1941.00
36_N66_K1.1861.00
13_N143_E1.1841.00
58_K62_D1.1761.00
143_E163_I1.1481.00
160_Y174_L1.1401.00
38_A61_T1.1381.00
38_A65_I1.1361.00
14_V32_I1.1351.00
238_I251_E1.1331.00
238_I248_A1.1291.00
219_N223_E1.1271.00
30_G208_I1.1261.00
218_R222_Y1.1251.00
14_V168_V1.1211.00
190_Q194_N1.1181.00
93_K130_V1.1151.00
136_R164_P1.1011.00
181_T184_A1.0901.00
14_V163_I1.0881.00
271_V274_Y1.0861.00
29_A40_V1.0801.00
11_S166_Q1.0791.00
220_A224_S1.0751.00
237_K241_T1.0721.00
193_I197_E1.0671.00
37_Y67_Y1.0661.00
90_I131_I1.0551.00
146_K162_Y1.0441.00
15_Y33_I1.0381.00
233_D237_K1.0381.00
149_Y159_I1.0341.00
42_D72_H1.0321.00
200_A221_L1.0281.00
131_I147_I1.0211.00
55_S58_K1.0171.00
77_H173_D1.0091.00
226_D230_F1.0071.00
14_V170_F1.0041.00
143_E165_D1.0031.00
227_Y231_V1.0011.00
138_F141_N1.0001.00
47_E50_A0.9951.00
204_A207_F0.9931.00
56_E60_I0.9931.00
72_H173_D0.9881.00
170_F208_I0.9851.00
17_F53_F0.9821.00
180_C184_A0.9801.00
144_E164_P0.9511.00
236_R240_R0.9471.00
164_P167_K0.9431.00
125_T128_E0.9381.00
180_C183_F0.9351.00
10_I208_I0.9201.00
76_D211_H0.9181.00
77_H211_H0.9171.00
96_R130_V0.9161.00
88_I128_E0.9041.00
29_A44_L0.9021.00
234_E237_K0.9021.00
109_P113_L0.8981.00
192_Y196_L0.8971.00
70_N78_L0.8931.00
92_H95_C0.8851.00
71_T170_F0.8831.00
220_A223_E0.8811.00
38_A57_I0.8741.00
15_Y60_I0.8731.00
96_R100_V0.8711.00
246_I250_Y0.8701.00
148_A162_Y0.8701.00
65_I84_F0.8691.00
181_T224_S0.8681.00
53_F57_I0.8681.00
68_L84_F0.8671.00
195_A198_N0.8631.00
52_Q55_S0.8621.00
173_D176_F0.8611.00
72_H77_H0.8601.00
30_G210_G0.8510.99
39_V139_I0.8470.99
148_A160_Y0.8420.99
47_E51_R0.8410.99
226_D229_I0.8370.99
17_F31_V0.8310.99
32_I163_I0.8300.99
160_Y169_V0.8280.99
110_Y113_L0.8270.99
194_N197_E0.8200.99
207_F215_S0.8180.99
50_A54_I0.8180.99
11_S14_V0.8170.99
140_D143_E0.8140.99
243_S247_R0.8120.99
9_R15_Y0.8110.99
43_S81_N0.8100.99
53_F58_K0.8090.99
174_L199_L0.8080.99
31_V60_I0.8080.99
68_L87_A0.8060.99
247_R250_Y0.8030.99
67_Y129_V0.8020.99
13_N33_I0.7980.99
131_I135_M0.7960.99
95_C157_S0.7920.99
241_T251_E0.7910.99
148_A198_N0.7890.99
149_Y152_Y0.7880.99
234_E238_I0.7860.99
162_Y202_L0.7840.99
29_A53_F0.7830.99
68_L81_N0.7810.99
232_R236_R0.7810.99
174_L195_A0.7750.99
50_A53_F0.7750.99
53_F56_E0.7720.99
36_N140_D0.7720.99
247_R251_E0.7700.99
124_Y127_Q0.7680.99
135_M147_I0.7610.99
69_I159_I0.7600.99
95_C99_V0.7590.99
206_I214_V0.7540.99
74_H77_H0.7440.99
233_D236_R0.7400.99
258_D261_I0.7380.99
154_H173_D0.7370.99
32_I145_I0.7360.99
238_I252_I0.7360.99
51_R54_I0.7360.99
237_K240_R0.7330.98
127_Q130_V0.7320.98
267_V271_V0.7320.98
10_I14_V0.7280.98
85_P125_T0.7250.98
215_S220_A0.7240.98
228_L269_N0.7220.98
158_D210_G0.7210.98
28_N212_G0.7200.98
53_F60_I0.7200.98
85_P128_E0.7190.98
183_F265_R0.7180.98
152_Y195_A0.7160.98
153_A158_D0.7140.98
81_N89_T0.7090.98
46_N49_M0.7070.98
153_A191_G0.7060.98
53_F61_T0.7040.98
234_E252_I0.7030.98
97_E100_V0.6970.98
169_V207_F0.6940.98
34_G37_Y0.6900.98
145_I170_F0.6870.98
203_D206_I0.6860.98
189_I192_Y0.6850.98
169_V204_A0.6840.98
171_T175_L0.6810.98
221_L225_R0.6810.98
28_N210_G0.6790.98
73_E155_T0.6760.97
68_L89_T0.6750.97
235_A248_A0.6750.97
162_Y203_D0.6720.97
41_V145_I0.6690.97
27_S210_G0.6680.97
171_T209_P0.6660.97
265_R268_G0.6630.97
94_N97_E0.6620.97
260_W263_K0.6610.97
139_I143_E0.6600.97
8_E16_A0.6600.97
40_V43_S0.6590.97
80_T83_L0.6590.97
163_I168_V0.6560.97
58_K61_T0.6560.97
120_S127_Q0.6510.97
95_C155_T0.6480.97
102_G105_R0.6430.97
34_G139_I0.6420.97
160_Y199_L0.6420.97
189_I232_R0.6380.96
82_H123_Q0.6380.96
177_S215_S0.6370.96
178_P213_E0.6350.96
119_F122_Y0.6280.96
248_A266_I0.6280.96
98_K101_E0.6260.96
35_K140_D0.6250.96
261_I266_I0.6230.96
71_T74_H0.6210.96
11_S143_E0.6200.96
35_K63_K0.6200.96
33_I61_T0.6150.96
196_L225_R0.6130.96
40_V65_I0.6120.95
31_V63_K0.6120.95
173_D177_S0.6110.95
28_N209_P0.6100.95
42_D173_D0.6080.95
95_C98_K0.6080.95
270_L274_Y0.6070.95
194_N198_N0.6060.95
29_A43_S0.6050.95
127_Q131_I0.6040.95
49_M56_E0.6030.95
19_Q29_A0.6020.95
134_E149_Y0.5990.95
76_D173_D0.5980.95
209_P215_S0.5940.95
41_V69_I0.5930.95
109_P112_N0.5930.95
91_C99_V0.5930.95
236_R279_G0.5920.95
57_I60_I0.5910.95
238_I241_T0.5900.95
235_A266_I0.5890.94
99_V126_P0.5890.94
273_A277_L0.5880.94
274_Y279_G0.5880.94
27_S45_T0.5870.94
34_G138_F0.5870.94
274_Y277_L0.5860.94
93_K97_E0.5850.94
204_A218_R0.5850.94
227_Y269_N0.5850.94
191_G194_N0.5840.94
11_S206_I0.5840.94
34_G39_V0.5840.94
41_V163_I0.5820.94
90_I95_C0.5810.94
32_I39_V0.5810.94
40_V68_L0.5800.94
174_L192_Y0.5800.94
231_V273_A0.5800.94
160_Y195_A0.5790.94
188_Y275_S0.5770.94
262_S265_R0.5770.94
37_Y63_K0.5740.94
40_V84_F0.5730.94
70_N89_T0.5730.94
17_F56_E0.5720.94
42_D77_H0.5700.93
38_A64_P0.5690.93
16_A30_G0.5690.93
46_N51_R0.5680.93
184_A268_G0.5660.93
224_S228_L0.5660.93
222_Y225_R0.5660.93
239_M278_K0.5660.93
49_M52_Q0.5630.93
73_E95_C0.5620.93
228_L231_V0.5620.93
193_I232_R0.5610.93
71_T77_H0.5600.93
13_N35_K0.5590.93
268_G271_V0.5590.93
73_E78_L0.5570.93
72_H76_D0.5570.93
160_Y171_T0.5560.93
208_I214_V0.5540.92
13_N165_D0.5530.92
78_L81_N0.5530.92
173_D211_H0.5530.92
73_E157_S0.5520.92
34_G140_D0.5520.92
39_V66_K0.5470.92
176_F209_P0.5460.92
97_E101_E0.5450.92
118_D121_G0.5450.92
192_Y228_L0.5440.92
26_L212_G0.5440.92
182_P224_S0.5430.92
269_N272_R0.5420.92
42_D71_T0.5410.92
228_L232_R0.5390.91
54_I61_T0.5340.91
49_M54_I0.5310.91
54_I65_I0.5300.91
155_T158_D0.5290.91
7_F15_Y0.5290.91
257_Y261_I0.5280.91
275_S278_K0.5280.91
205_E217_G0.5260.90
66_K88_I0.5240.90
54_I57_I0.5220.90
47_E83_L0.5190.90
40_V53_F0.5170.90
78_L99_V0.5150.89
224_S227_Y0.5150.89
229_I232_R0.5130.89
34_G143_E0.5120.89
175_L209_P0.5100.89
49_M53_F0.5090.89
239_M273_A0.5090.89
190_Q193_I0.5030.88
235_A270_L0.5030.88
69_I90_I0.5030.88
54_I83_L0.5030.88
256_K259_E0.5020.88
192_Y231_V0.5020.88
221_L224_S0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yheA 3 0.9773 100 0.295 Contact Map
2cfuA 2 0.9643 100 0.322 Contact Map
4pdxA 2 0.9675 100 0.327 Contact Map
4nurA 2 0.9805 100 0.334 Contact Map
2zo4A 1 0.8961 100 0.367 Contact Map
4ad9A 4 0.8701 100 0.436 Contact Map
2fhxA 2 0.7435 100 0.463 Contact Map
3q6vA 1 0.7143 100 0.476 Contact Map
2vw8A 2 0.8701 100 0.48 Contact Map
3iogA 1 0.724 100 0.481 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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