Q97VU0 - SULSO - GREMLIN Contacts

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Q97VU0 - Cyclase/dehydrase, putative

UniProt:	Q97VU0	Sequences: MEVQYKFERISDNVYAFIQPNGDWFLSNAGVIIGKNYAVVVDSLTNEKMARQFISEIKKITDKPIKYLINTHEHEDHLWTNHLFPNAITICHKNCREKVVEGAKRRINPYENLFNAIDFSGYQYTPQEVVIKDEMRIFIDNDEEIKIAYVGYAHTTSDIYVYIPDQKVVFTGDLLFSPPCTPFALMGYIQGYINALENLANLDAEIFIPGHGEVSYGRNALYESRDYLIFVRDEARKIMRTISDPIRAAYEINLGKYDEWISKERIVGNLVRAYSELKGNPPASKLENIDKVLLEMIRYREKKGGGKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	308 (267)
Sequences:	5644 (4259)
Seq/√Len:	260.6

ECOLI - YJCS YCBL GLO2
BACSU - YQJP YFLN YOBT YYBB YQGX PKSB
HALSA - Q9HNJ9 Q9HRG5 Q9HSD1 Q9HSH2
SULSO - Q97VU0 Q97VU4 Q97UV2 Q97WC2 Q7LYK3 Q97U88 Q97UR2 Q97XZ1 Q97YZ2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
197_E	225_R	4.246	1.00
200_A	222_Y	3.794	1.00
146_K	164_P	3.771	1.00
167_K	205_E	3.235	1.00
70_N	81_N	3.209	1.00
41_V	71_T	3.171	1.00
9_R	12_D	2.863	1.00
244_D	247_R	2.732	1.00
136_R	144_E	2.720	1.00
37_Y	66_K	2.624	1.00
200_A	225_R	2.598	1.00
236_R	278_K	2.584	1.00
93_K	132_K	2.555	1.00
163_I	166_Q	2.555	1.00
69_I	161_V	2.537	1.00
138_F	144_E	2.481	1.00
133_D	198_N	2.435	1.00
144_E	165_D	2.344	1.00
136_R	146_K	2.296	1.00
168_V	208_I	2.293	1.00
88_I	129_V	2.286	1.00
158_D	172_G	2.222	1.00
67_Y	90_I	2.132	1.00
67_Y	88_I	2.125	1.00
143_E	166_Q	2.079	1.00
41_V	170_F	2.025	1.00
71_T	172_G	1.994	1.00
39_V	67_Y	1.985	1.00
30_G	170_F	1.925	1.00
151_G	160_Y	1.894	1.00
239_M	279_G	1.890	1.00
147_I	159_I	1.887	1.00
92_H	149_Y	1.797	1.00
222_Y	226_D	1.791	1.00
9_R	13_N	1.789	1.00
90_I	129_V	1.760	1.00
188_Y	191_G	1.748	1.00
197_E	229_I	1.735	1.00
43_S	68_L	1.682	1.00
272_R	276_E	1.675	1.00
257_Y	260_W	1.654	1.00
92_H	159_I	1.653	1.00
198_N	201_N	1.640	1.00
54_I	58_K	1.629	1.00
51_R	55_S	1.597	1.00
55_S	59_K	1.595	1.00
197_E	201_N	1.593	1.00
56_E	59_K	1.580	1.00
147_I	161_V	1.578	1.00
206_I	216_Y	1.554	1.00
193_I	225_R	1.535	1.00
131_I	159_I	1.503	1.00
151_G	195_A	1.503	1.00
171_T	207_F	1.496	1.00
145_I	163_I	1.492	1.00
200_A	218_R	1.485	1.00
50_A	83_L	1.482	1.00
229_I	233_D	1.474	1.00
196_L	221_L	1.467	1.00
33_I	63_K	1.456	1.00
31_V	38_A	1.439	1.00
33_I	38_A	1.439	1.00
167_K	203_D	1.431	1.00
193_I	229_I	1.413	1.00
169_V	202_L	1.381	1.00
203_D	218_R	1.378	1.00
168_V	206_I	1.376	1.00
32_I	41_V	1.373	1.00
162_Y	169_V	1.370	1.00
13_N	166_Q	1.370	1.00
91_C	95_C	1.365	1.00
146_K	202_L	1.360	1.00
243_S	251_E	1.359	1.00
245_P	249_A	1.353	1.00
41_V	161_V	1.342	1.00
132_K	135_M	1.328	1.00
39_V	69_I	1.316	1.00
129_V	135_M	1.314	1.00
261_I	264_E	1.308	1.00
162_Y	167_K	1.307	1.00
145_I	161_V	1.300	1.00
57_I	61_T	1.299	1.00
151_G	158_D	1.294	1.00
39_V	145_I	1.282	1.00
37_Y	64_P	1.269	1.00
238_I	243_S	1.269	1.00
175_L	221_L	1.256	1.00
134_E	146_K	1.252	1.00
225_R	229_I	1.240	1.00
52_Q	56_E	1.238	1.00
153_A	195_A	1.230	1.00
133_D	149_Y	1.229	1.00
162_Y	204_A	1.222	1.00
209_P	212_G	1.221	1.00
197_E	200_A	1.220	1.00
31_V	40_V	1.217	1.00
199_L	202_L	1.210	1.00
71_T	161_V	1.203	1.00
31_V	57_I	1.194	1.00
36_N	66_K	1.186	1.00
13_N	143_E	1.184	1.00
58_K	62_D	1.176	1.00
143_E	163_I	1.148	1.00
160_Y	174_L	1.140	1.00
38_A	61_T	1.138	1.00
38_A	65_I	1.136	1.00
14_V	32_I	1.135	1.00
238_I	251_E	1.133	1.00
238_I	248_A	1.129	1.00
219_N	223_E	1.127	1.00
30_G	208_I	1.126	1.00
218_R	222_Y	1.125	1.00
14_V	168_V	1.121	1.00
190_Q	194_N	1.118	1.00
93_K	130_V	1.115	1.00
136_R	164_P	1.101	1.00
181_T	184_A	1.090	1.00
14_V	163_I	1.088	1.00
271_V	274_Y	1.086	1.00
29_A	40_V	1.080	1.00
11_S	166_Q	1.079	1.00
220_A	224_S	1.075	1.00
237_K	241_T	1.072	1.00
193_I	197_E	1.067	1.00
37_Y	67_Y	1.066	1.00
90_I	131_I	1.055	1.00
146_K	162_Y	1.044	1.00
15_Y	33_I	1.038	1.00
233_D	237_K	1.038	1.00
149_Y	159_I	1.034	1.00
42_D	72_H	1.032	1.00
200_A	221_L	1.028	1.00
131_I	147_I	1.021	1.00
55_S	58_K	1.017	1.00
77_H	173_D	1.009	1.00
226_D	230_F	1.007	1.00
14_V	170_F	1.004	1.00
143_E	165_D	1.003	1.00
227_Y	231_V	1.001	1.00
138_F	141_N	1.000	1.00
47_E	50_A	0.995	1.00
204_A	207_F	0.993	1.00
56_E	60_I	0.993	1.00
72_H	173_D	0.988	1.00
170_F	208_I	0.985	1.00
17_F	53_F	0.982	1.00
180_C	184_A	0.980	1.00
144_E	164_P	0.951	1.00
236_R	240_R	0.947	1.00
164_P	167_K	0.943	1.00
125_T	128_E	0.938	1.00
180_C	183_F	0.935	1.00
10_I	208_I	0.920	1.00
76_D	211_H	0.918	1.00
77_H	211_H	0.917	1.00
96_R	130_V	0.916	1.00
88_I	128_E	0.904	1.00
29_A	44_L	0.902	1.00
234_E	237_K	0.902	1.00
109_P	113_L	0.898	1.00
192_Y	196_L	0.897	1.00
70_N	78_L	0.893	1.00
92_H	95_C	0.885	1.00
71_T	170_F	0.883	1.00
220_A	223_E	0.881	1.00
38_A	57_I	0.874	1.00
15_Y	60_I	0.873	1.00
96_R	100_V	0.871	1.00
246_I	250_Y	0.870	1.00
148_A	162_Y	0.870	1.00
65_I	84_F	0.869	1.00
181_T	224_S	0.868	1.00
53_F	57_I	0.868	1.00
68_L	84_F	0.867	1.00
195_A	198_N	0.863	1.00
52_Q	55_S	0.862	1.00
173_D	176_F	0.861	1.00
72_H	77_H	0.860	1.00
30_G	210_G	0.851	0.99
39_V	139_I	0.847	0.99
148_A	160_Y	0.842	0.99
47_E	51_R	0.841	0.99
226_D	229_I	0.837	0.99
17_F	31_V	0.831	0.99
32_I	163_I	0.830	0.99
160_Y	169_V	0.828	0.99
110_Y	113_L	0.827	0.99
194_N	197_E	0.820	0.99
207_F	215_S	0.818	0.99
50_A	54_I	0.818	0.99
11_S	14_V	0.817	0.99
140_D	143_E	0.814	0.99
243_S	247_R	0.812	0.99
9_R	15_Y	0.811	0.99
43_S	81_N	0.810	0.99
53_F	58_K	0.809	0.99
174_L	199_L	0.808	0.99
31_V	60_I	0.808	0.99
68_L	87_A	0.806	0.99
247_R	250_Y	0.803	0.99
67_Y	129_V	0.802	0.99
13_N	33_I	0.798	0.99
131_I	135_M	0.796	0.99
95_C	157_S	0.792	0.99
241_T	251_E	0.791	0.99
148_A	198_N	0.789	0.99
149_Y	152_Y	0.788	0.99
234_E	238_I	0.786	0.99
162_Y	202_L	0.784	0.99
29_A	53_F	0.783	0.99
68_L	81_N	0.781	0.99
232_R	236_R	0.781	0.99
174_L	195_A	0.775	0.99
50_A	53_F	0.775	0.99
53_F	56_E	0.772	0.99
36_N	140_D	0.772	0.99
247_R	251_E	0.770	0.99
124_Y	127_Q	0.768	0.99
135_M	147_I	0.761	0.99
69_I	159_I	0.760	0.99
95_C	99_V	0.759	0.99
206_I	214_V	0.754	0.99
74_H	77_H	0.744	0.99
233_D	236_R	0.740	0.99
258_D	261_I	0.738	0.99
154_H	173_D	0.737	0.99
32_I	145_I	0.736	0.99
238_I	252_I	0.736	0.99
51_R	54_I	0.736	0.99
237_K	240_R	0.733	0.98
127_Q	130_V	0.732	0.98
267_V	271_V	0.732	0.98
10_I	14_V	0.728	0.98
85_P	125_T	0.725	0.98
215_S	220_A	0.724	0.98
228_L	269_N	0.722	0.98
158_D	210_G	0.721	0.98
28_N	212_G	0.720	0.98
53_F	60_I	0.720	0.98
85_P	128_E	0.719	0.98
183_F	265_R	0.718	0.98
152_Y	195_A	0.716	0.98
153_A	158_D	0.714	0.98
81_N	89_T	0.709	0.98
46_N	49_M	0.707	0.98
153_A	191_G	0.706	0.98
53_F	61_T	0.704	0.98
234_E	252_I	0.703	0.98
97_E	100_V	0.697	0.98
169_V	207_F	0.694	0.98
34_G	37_Y	0.690	0.98
145_I	170_F	0.687	0.98
203_D	206_I	0.686	0.98
189_I	192_Y	0.685	0.98
169_V	204_A	0.684	0.98
171_T	175_L	0.681	0.98
221_L	225_R	0.681	0.98
28_N	210_G	0.679	0.98
73_E	155_T	0.676	0.97
68_L	89_T	0.675	0.97
235_A	248_A	0.675	0.97
162_Y	203_D	0.672	0.97
41_V	145_I	0.669	0.97
27_S	210_G	0.668	0.97
171_T	209_P	0.666	0.97
265_R	268_G	0.663	0.97
94_N	97_E	0.662	0.97
260_W	263_K	0.661	0.97
139_I	143_E	0.660	0.97
8_E	16_A	0.660	0.97
40_V	43_S	0.659	0.97
80_T	83_L	0.659	0.97
163_I	168_V	0.656	0.97
58_K	61_T	0.656	0.97
120_S	127_Q	0.651	0.97
95_C	155_T	0.648	0.97
102_G	105_R	0.643	0.97
34_G	139_I	0.642	0.97
160_Y	199_L	0.642	0.97
189_I	232_R	0.638	0.96
82_H	123_Q	0.638	0.96
177_S	215_S	0.637	0.96
178_P	213_E	0.635	0.96
119_F	122_Y	0.628	0.96
248_A	266_I	0.628	0.96
98_K	101_E	0.626	0.96
35_K	140_D	0.625	0.96
261_I	266_I	0.623	0.96
71_T	74_H	0.621	0.96
11_S	143_E	0.620	0.96
35_K	63_K	0.620	0.96
33_I	61_T	0.615	0.96
196_L	225_R	0.613	0.96
40_V	65_I	0.612	0.95
31_V	63_K	0.612	0.95
173_D	177_S	0.611	0.95
28_N	209_P	0.610	0.95
42_D	173_D	0.608	0.95
95_C	98_K	0.608	0.95
270_L	274_Y	0.607	0.95
194_N	198_N	0.606	0.95
29_A	43_S	0.605	0.95
127_Q	131_I	0.604	0.95
49_M	56_E	0.603	0.95
19_Q	29_A	0.602	0.95
134_E	149_Y	0.599	0.95
76_D	173_D	0.598	0.95
209_P	215_S	0.594	0.95
41_V	69_I	0.593	0.95
109_P	112_N	0.593	0.95
91_C	99_V	0.593	0.95
236_R	279_G	0.592	0.95
57_I	60_I	0.591	0.95
238_I	241_T	0.590	0.95
235_A	266_I	0.589	0.94
99_V	126_P	0.589	0.94
273_A	277_L	0.588	0.94
274_Y	279_G	0.588	0.94
27_S	45_T	0.587	0.94
34_G	138_F	0.587	0.94
274_Y	277_L	0.586	0.94
93_K	97_E	0.585	0.94
204_A	218_R	0.585	0.94
227_Y	269_N	0.585	0.94
191_G	194_N	0.584	0.94
11_S	206_I	0.584	0.94
34_G	39_V	0.584	0.94
41_V	163_I	0.582	0.94
90_I	95_C	0.581	0.94
32_I	39_V	0.581	0.94
40_V	68_L	0.580	0.94
174_L	192_Y	0.580	0.94
231_V	273_A	0.580	0.94
160_Y	195_A	0.579	0.94
188_Y	275_S	0.577	0.94
262_S	265_R	0.577	0.94
37_Y	63_K	0.574	0.94
40_V	84_F	0.573	0.94
70_N	89_T	0.573	0.94
17_F	56_E	0.572	0.94
42_D	77_H	0.570	0.93
38_A	64_P	0.569	0.93
16_A	30_G	0.569	0.93
46_N	51_R	0.568	0.93
184_A	268_G	0.566	0.93
224_S	228_L	0.566	0.93
222_Y	225_R	0.566	0.93
239_M	278_K	0.566	0.93
49_M	52_Q	0.563	0.93
73_E	95_C	0.562	0.93
228_L	231_V	0.562	0.93
193_I	232_R	0.561	0.93
71_T	77_H	0.560	0.93
13_N	35_K	0.559	0.93
268_G	271_V	0.559	0.93
73_E	78_L	0.557	0.93
72_H	76_D	0.557	0.93
160_Y	171_T	0.556	0.93
208_I	214_V	0.554	0.92
13_N	165_D	0.553	0.92
78_L	81_N	0.553	0.92
173_D	211_H	0.553	0.92
73_E	157_S	0.552	0.92
34_G	140_D	0.552	0.92
39_V	66_K	0.547	0.92
176_F	209_P	0.546	0.92
97_E	101_E	0.545	0.92
118_D	121_G	0.545	0.92
192_Y	228_L	0.544	0.92
26_L	212_G	0.544	0.92
182_P	224_S	0.543	0.92
269_N	272_R	0.542	0.92
42_D	71_T	0.541	0.92
228_L	232_R	0.539	0.91
54_I	61_T	0.534	0.91
49_M	54_I	0.531	0.91
54_I	65_I	0.530	0.91
155_T	158_D	0.529	0.91
7_F	15_Y	0.529	0.91
257_Y	261_I	0.528	0.91
275_S	278_K	0.528	0.91
205_E	217_G	0.526	0.90
66_K	88_I	0.524	0.90
54_I	57_I	0.522	0.90
47_E	83_L	0.519	0.90
40_V	53_F	0.517	0.90
78_L	99_V	0.515	0.89
224_S	227_Y	0.515	0.89
229_I	232_R	0.513	0.89
34_G	143_E	0.512	0.89
175_L	209_P	0.510	0.89
49_M	53_F	0.509	0.89
239_M	273_A	0.509	0.89
190_Q	193_I	0.503	0.88
235_A	270_L	0.503	0.88
69_I	90_I	0.503	0.88
54_I	83_L	0.503	0.88
256_K	259_E	0.502	0.88
192_Y	231_V	0.502	0.88
221_L	224_S	0.500	0.88

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yheA	3	0.9773	100	0.295	Contact Map
2cfuA	2	0.9643	100	0.322	Contact Map
4pdxA	2	0.9675	100	0.327	Contact Map
4nurA	2	0.9805	100	0.334	Contact Map
2zo4A	1	0.8961	100	0.367	Contact Map
4ad9A	4	0.8701	100	0.436	Contact Map
2fhxA	2	0.7435	100	0.463	Contact Map
3q6vA	1	0.7143	100	0.476	Contact Map
2vw8A	2	0.8701	100	0.48	Contact Map
3iogA	1	0.724	100	0.481	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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