GREMLIN Database
Q97VT9 - 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HpcE-1)
UniProt: Q97VT9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 318 (253)
Sequences: 3816 (2537)
Seq/√Len: 159.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_R247_D3.6211.00
175_D178_R3.6181.00
189_F277_G3.6041.00
171_G174_I3.1231.00
164_A189_F3.1031.00
241_N297_S3.0741.00
239_K244_I2.9471.00
174_I182_Y2.8951.00
176_K262_A2.8461.00
256_S259_D2.7101.00
239_K300_E2.7061.00
237_Y302_Y2.6931.00
161_L238_A2.6291.00
178_R181_D2.6111.00
180_R183_I2.6091.00
244_I247_D2.5791.00
186_F225_K2.4791.00
176_K259_D2.4561.00
237_Y247_D2.4551.00
161_L301_L2.3961.00
240_V293_L2.2551.00
159_I245_W2.1641.00
176_K256_S2.1511.00
60_L184_L2.1491.00
189_F216_N2.1141.00
142_Y146_E2.1001.00
213_D269_Y2.0811.00
248_T252_D2.0631.00
171_G182_Y2.0341.00
239_K302_Y2.0211.00
218_L275_V1.9631.00
170_R271_R1.9261.00
170_R272_P1.9111.00
180_R258_E1.8801.00
167_I261_I1.8641.00
55_D58_G1.8481.00
140_I269_Y1.8191.00
164_A187_T1.8131.00
224_T227_E1.8121.00
165_A257_F1.8011.00
187_T218_L1.7961.00
184_L222_I1.7821.00
161_L236_V1.7811.00
86_N89_Q1.7551.00
163_I303_V1.6911.00
240_V245_W1.6671.00
164_A275_V1.6611.00
235_R304_E1.6281.00
237_Y244_I1.6181.00
143_G146_E1.6151.00
154_S196_D1.5891.00
235_R249_K1.5831.00
188_I303_V1.5741.00
91_K146_E1.5641.00
166_I222_I1.5611.00
170_R182_Y1.5361.00
133_Y264_V1.5351.00
245_W291_K1.5321.00
164_A277_G1.5281.00
87_I92_L1.5071.00
187_T306_I1.4951.00
92_L144_H1.4871.00
192_F217_G1.4571.00
228_L234_L1.4431.00
163_I250_A1.4231.00
232_K258_E1.4221.00
148_V192_F1.4181.00
149_P214_F1.3991.00
197_I212_K1.3691.00
104_D133_Y1.3581.00
109_R113_E1.3571.00
59_V70_V1.3491.00
94_A144_H1.3491.00
94_A141_F1.3421.00
85_Y90_V1.3231.00
107_A260_M1.3131.00
53_P58_G1.3121.00
150_W157_V1.2881.00
110_G252_D1.2811.00
135_K207_G1.2781.00
238_A301_L1.2661.00
169_K272_P1.2621.00
165_A276_F1.2501.00
71_K75_E1.2491.00
57_L61_Q1.2461.00
233_G251_E1.2341.00
98_R271_R1.2331.00
139_A271_R1.2221.00
62_A65_K1.2171.00
63_G66_G1.2151.00
63_G67_F1.2121.00
216_N277_G1.2091.00
236_V240_V1.2071.00
77_S81_N1.1921.00
104_D260_M1.1791.00
137_D211_G1.1761.00
152_K173_D1.1521.00
68_E226_D1.1401.00
180_R232_K1.1361.00
172_K213_D1.1331.00
148_V299_I1.1251.00
270_I276_F1.1231.00
287_L291_K1.1231.00
170_R174_I1.0941.00
110_G282_S1.0930.99
154_S157_V1.0930.99
140_I216_N1.0820.99
234_L240_V1.0720.99
131_P260_M1.0680.99
77_S80_R1.0570.99
148_V215_A1.0570.99
183_I257_F1.0560.99
115_T118_R1.0440.99
153_Y173_D1.0440.99
156_L196_D1.0390.99
69_V72_E1.0370.99
103_R209_A1.0330.99
169_K182_Y1.0300.99
188_I301_L1.0280.99
242_N298_S1.0260.99
169_K181_D1.0220.99
229_S305_K1.0130.99
166_I187_T0.9970.99
223_V306_I0.9920.99
168_Y184_L0.9890.99
165_A186_F0.9750.99
234_L303_V0.9740.99
101_M135_K0.9620.99
189_F218_L0.9620.99
234_L238_A0.9610.99
239_K242_N0.9580.99
106_L115_T0.9570.99
56_M222_I0.9550.99
233_G249_K0.9530.99
194_A215_A0.9480.99
62_A66_G0.9450.99
108_F278_S0.9390.98
176_K258_E0.9340.98
67_F71_K0.9230.98
57_L98_R0.9200.98
159_I293_L0.9200.98
193_S198_Q0.9120.98
245_W287_L0.9120.98
165_A261_I0.9080.98
208_P267_D0.9070.98
107_A281_V0.9050.98
243_E291_K0.9040.98
157_V215_A0.8960.98
210_K266_Q0.8950.98
59_V66_G0.8940.98
132_I206_L0.8930.98
158_D195_R0.8890.98
168_Y272_P0.8870.98
111_H158_D0.8870.98
179_A183_I0.8850.98
220_P223_V0.8840.98
174_I265_S0.8780.98
285_T289_I0.8750.98
73_I76_W0.8670.97
64_D67_F0.8460.97
166_I275_V0.8460.97
96_L166_I0.8460.97
238_A299_I0.8390.97
228_L306_I0.8380.97
175_D262_A0.8340.97
156_L292_S0.8220.96
148_V214_F0.8210.96
58_G62_A0.8200.96
157_V214_F0.8120.96
230_D233_G0.8110.96
102_L135_K0.8020.96
137_D207_G0.8000.96
242_N300_E0.7990.96
287_L290_G0.7980.96
285_T292_S0.7960.96
261_I270_I0.7950.96
154_S194_A0.7930.96
66_G70_V0.7900.96
55_D98_R0.7900.96
150_W295_P0.7880.95
232_K256_S0.7880.95
232_K253_M0.7860.95
293_L299_I0.7840.95
116_Y119_R0.7820.95
167_I270_I0.7810.95
66_G69_V0.7800.95
112_V282_S0.7800.95
80_R83_I0.7780.95
250_A257_F0.7760.95
237_Y304_E0.7710.95
240_V299_I0.7660.95
164_A218_L0.7650.95
157_V295_P0.7630.95
106_L112_V0.7630.95
231_I250_A0.7630.95
213_D266_Q0.7590.94
185_G222_I0.7580.94
130_I200_A0.7540.94
69_V73_I0.7510.94
159_I301_L0.7470.94
60_L96_L0.7470.94
236_V242_N0.7440.94
163_I186_F0.7440.94
246_C283_G0.7400.94
234_L242_N0.7360.94
111_H198_Q0.7320.93
87_I221_W0.7290.93
187_T219_G0.7270.93
115_T193_S0.7270.93
63_G68_E0.7260.93
183_I186_F0.7200.93
112_V123_I0.7200.93
255_W259_D0.7190.93
109_R254_Q0.7180.93
164_A216_N0.7150.93
142_Y214_F0.7140.92
201_E208_P0.7120.92
221_W306_I0.7100.92
141_F218_L0.7070.92
151_P212_K0.7060.92
54_P58_G0.7050.92
170_R269_Y0.7040.92
77_S84_L0.7040.92
207_G212_K0.7030.92
201_E207_G0.7020.92
172_K269_Y0.7020.92
64_D226_D0.7000.92
151_P215_A0.6960.92
229_S232_K0.6950.91
94_A143_G0.6950.91
110_G284_C0.6930.91
186_F231_I0.6870.91
61_Q272_P0.6850.91
60_L67_F0.6850.91
187_T222_I0.6850.91
114_A283_G0.6840.91
124_P255_W0.6790.90
111_H195_R0.6770.90
106_L193_S0.6760.90
234_L250_A0.6740.90
181_D225_K0.6720.90
218_L277_G0.6710.90
250_A304_E0.6680.90
175_D182_Y0.6670.90
56_M59_V0.6650.90
194_A197_I0.6650.90
106_L132_I0.6640.90
104_D264_V0.6620.89
178_R182_Y0.6580.89
153_Y194_A0.6550.89
109_R123_I0.6550.89
237_Y240_V0.6540.89
107_A250_A0.6540.89
180_R225_K0.6540.89
141_F144_H0.6430.88
60_L166_I0.6410.88
258_E262_A0.6410.88
262_A265_S0.6380.88
250_A253_M0.6380.88
65_K68_E0.6370.88
186_F257_F0.6360.87
142_Y215_A0.6360.87
72_E76_W0.6350.87
259_D262_A0.6340.87
236_V239_K0.6310.87
212_K267_D0.6290.87
64_D68_E0.6290.87
59_V63_G0.6280.87
54_P73_I0.6250.87
198_Q205_L0.6240.86
108_F250_A0.6230.86
113_E117_K0.6230.86
143_G220_P0.6230.86
99_A141_F0.6220.86
72_E75_E0.6200.86
261_I276_F0.6200.86
241_N298_S0.6190.86
115_T199_M0.6190.86
162_E280_T0.6180.86
100_N137_D0.6150.86
139_A213_D0.6140.86
59_V67_F0.6130.85
138_P141_F0.6110.85
65_K69_V0.6100.85
240_V270_I0.6070.85
156_L199_M0.6060.85
161_L188_I0.6050.85
85_Y89_Q0.6030.85
112_V254_Q0.6020.84
262_A266_Q0.6010.84
60_L222_I0.5980.84
200_A263_Y0.5960.84
115_T121_Q0.5950.84
74_L77_S0.5930.84
155_K196_D0.5920.83
79_K83_I0.5920.83
180_R257_F0.5910.83
240_V297_S0.5900.83
260_M278_S0.5890.83
253_M260_M0.5870.83
174_I178_R0.5860.83
163_I281_V0.5830.83
188_I306_I0.5800.82
51_I73_I0.5770.82
151_P154_S0.5770.82
102_L268_E0.5760.82
257_F278_S0.5750.82
207_G211_G0.5740.82
250_A278_S0.5710.81
261_I265_S0.5710.81
193_S199_M0.5700.81
183_I225_K0.5700.81
51_I70_V0.5700.81
183_I261_I0.5690.81
58_G61_Q0.5680.81
68_E71_K0.5640.80
177_I262_A0.5640.80
52_V59_V0.5630.80
115_T292_S0.5620.80
133_Y260_M0.5610.80
160_E191_D0.5610.80
223_V228_L0.5600.80
157_V194_A0.5550.79
205_L290_G0.5510.79
239_K247_D0.5510.79
192_F299_I0.5510.79
133_Y263_Y0.5470.78
107_A246_C0.5450.78
160_E280_T0.5430.78
112_V121_Q0.5400.77
235_R240_V0.5380.77
149_P152_K0.5370.77
215_A269_Y0.5360.77
264_V270_I0.5360.77
208_P268_E0.5340.77
93_K143_G0.5330.77
174_I270_I0.5330.77
190_N299_I0.5320.76
195_R198_Q0.5320.76
206_L213_D0.5310.76
136_G216_N0.5300.76
112_V122_P0.5300.76
153_Y294_K0.5300.76
234_L249_K0.5280.76
78_K81_N0.5270.76
103_R211_G0.5270.76
238_A242_N0.5260.76
135_K213_D0.5260.76
70_V74_L0.5250.76
253_M258_E0.5230.75
201_E267_D0.5220.75
96_L272_P0.5220.75
114_A281_V0.5220.75
264_V276_F0.5210.75
92_L95_P0.5200.75
118_R124_P0.5200.75
218_L222_I0.5200.75
291_K294_K0.5190.75
80_R84_L0.5190.75
168_Y182_Y0.5180.75
52_V74_L0.5180.75
114_A284_C0.5180.75
271_R274_D0.5170.74
78_K82_D0.5170.74
286_G289_I0.5160.74
112_V115_T0.5160.74
62_A67_F0.5150.74
83_I86_N0.5130.74
102_L137_D0.5130.74
100_N213_D0.5120.74
111_H191_D0.5120.74
102_L133_Y0.5100.73
264_V268_E0.5090.73
184_L225_K0.5080.73
105_F111_H0.5070.73
225_K261_I0.5050.73
233_G238_A0.5050.73
87_I90_V0.5030.72
96_L99_A0.5020.72
103_R206_L0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r6oA 2 0.8176 100 0.242 Contact Map
3lzkA 2 0.9214 100 0.255 Contact Map
4qkuA 2 0.9654 100 0.275 Contact Map
4dbfA 2 0.7956 100 0.304 Contact Map
3rr6A 1 0.7925 100 0.309 Contact Map
1hyoA 2 0.9686 100 0.313 Contact Map
1wzoA 4 0.7547 100 0.319 Contact Map
2dfuA 2 0.7516 100 0.332 Contact Map
2q18X 3 0.8428 100 0.338 Contact Map
1gttA 1 0.8994 100 0.371 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.