Q97VT8 - SULSO - GREMLIN Contacts

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Q97VT8 - Lipase (LipP-2)

UniProt:	Q97VT8	Sequences: MPLDPQVKELLTKINLLLPTTPLTPQEFRKVRNELFIKMFNNEKVGLYNIRDMTIPVRNGDIKVRVYFPNQRENLPAVVYYHGGGFVYGNLDTHDSVCRLISKLSNTIIVSVDYRLAPEHKFPTQVYDAYDVVKWLANNGGKLSIDTSKIAVAGDSAGGNLSTVVSILDRDNGENVVKYQIMIYPVVNMLDSSPSMYNYGDGYFLTYERILWYNKQYVKEDSDYYNPLASPILAESHNLPPALIITAEYDPLRDQGEMYAHKLKVSGVKTISLRYNGMIHGFVSFYEYLDTGKEAIHHIASSIRKMFNVFY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (263)
Sequences:	11755 (9187)
Seq/√Len:	566.5

ECOLI - AES
BACSU - YTMA
SULSO - Q97VT8 Q97VW1 Q97VU2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
115_R	128_D	4.039	1.00
81_Y	129_A	3.674	1.00
151_A	179_Y	3.275	1.00
78_V	153_A	2.856	1.00
273_L	298_H	2.838	1.00
77_A	145_I	2.666	1.00
257_E	274_R	2.590	1.00
120_H	124_T	2.569	1.00
139_N	142_K	2.472	1.00
260_A	270_T	2.349	1.00
133_V	177_V	2.331	1.00
183_I	299_I	2.292	1.00
260_A	272_S	2.210	1.00
79_V	132_V	2.167	1.00
86_F	160_N	2.163	1.00
275_Y	298_H	2.128	1.00
166_S	180_Q	2.109	1.00
91_L	113_D	2.105	1.00
135_W	139_N	2.069	1.00
263_L	268_V	2.060	1.00
246_T	256_G	2.049	1.00
181_I	299_I	1.977	1.00
179_Y	302_S	1.964	1.00
110_V	136_L	1.963	1.00
244_I	260_A	1.949	1.00
257_E	272_S	1.913	1.00
112_V	132_V	1.883	1.00
66_V	110_V	1.881	1.00
130_Y	168_L	1.871	1.00
180_Q	242_A	1.865	1.00
168_L	172_N	1.851	1.00
242_A	263_L	1.823	1.00
146_D	149_K	1.788	1.00
104_L	297_H	1.786	1.00
108_I	145_I	1.760	1.00
80_Y	153_A	1.758	1.00
163_T	259_Y	1.751	1.00
129_A	165_V	1.718	1.00
94_H	155_D	1.704	1.00
95_D	99_R	1.702	1.00
261_H	265_V	1.698	1.00
182_M	185_P	1.696	1.00
65_R	91_L	1.668	1.00
246_T	274_R	1.640	1.00
260_A	264_K	1.634	1.00
248_E	276_N	1.621	1.00
163_T	182_M	1.608	1.00
68_F	108_I	1.602	1.00
104_L	300_A	1.594	1.00
77_A	136_L	1.594	1.00
98_C	109_I	1.578	1.00
151_A	303_I	1.574	1.00
127_Y	168_L	1.573	1.00
195_S	254_D	1.564	1.00
100_L	104_L	1.561	1.00
79_V	133_V	1.551	1.00
168_L	228_L	1.544	1.00
78_V	107_T	1.540	1.00
170_R	238_N	1.536	1.00
244_I	256_G	1.533	1.00
264_K	270_T	1.532	1.00
126_V	164_V	1.530	1.00
153_A	181_I	1.510	1.00
77_A	110_V	1.505	1.00
75_L	108_I	1.494	1.00
130_Y	169_D	1.486	1.00
243_L	273_L	1.446	1.00
152_V	162_S	1.433	1.00
86_F	186_V	1.418	1.00
212_W	216_Q	1.413	1.00
114_Y	157_A	1.391	1.00
246_T	272_S	1.378	1.00
243_L	302_S	1.377	1.00
64_V	110_V	1.373	1.00
58_R	131_D	1.368	1.00
189_M	230_S	1.367	1.00
54_T	61_D	1.341	1.00
179_Y	243_L	1.336	1.00
262_K	265_V	1.335	1.00
102_S	109_I	1.335	1.00
184_Y	281_G	1.332	1.00
262_K	266_S	1.318	1.00
130_Y	134_K	1.305	1.00
180_Q	259_Y	1.302	1.00
53_M	64_V	1.296	1.00
81_Y	112_V	1.291	1.00
65_R	95_D	1.289	1.00
241_P	269_K	1.274	1.00
261_H	264_K	1.262	1.00
79_V	136_L	1.255	1.00
133_V	165_V	1.245	1.00
66_V	108_I	1.240	1.00
64_V	132_V	1.221	1.00
253_R	257_E	1.203	1.00
80_Y	94_H	1.201	1.00
297_H	301_S	1.198	1.00
167_I	234_A	1.195	1.00
271_I	298_H	1.192	1.00
63_K	113_D	1.189	1.00
122_F	229_A	1.187	1.00
289_L	292_G	1.178	1.00
98_C	111_S	1.177	1.00
271_I	305_K	1.176	1.00
184_Y	283_V	1.175	1.00
258_M	261_H	1.167	1.00
134_K	138_N	1.164	1.00
77_A	108_I	1.153	1.00
53_M	66_V	1.149	1.00
218_V	229_A	1.146	1.00
52_D	65_R	1.127	1.00
124_T	128_D	1.122	1.00
278_M	291_T	1.110	1.00
291_T	294_E	1.092	1.00
134_K	172_N	1.085	1.00
198_N	253_R	1.085	1.00
171_D	228_L	1.084	1.00
275_Y	282_F	1.078	1.00
230_S	233_L	1.078	1.00
133_V	137_A	1.075	1.00
207_Y	211_L	1.073	1.00
162_S	182_M	1.067	1.00
254_D	257_E	1.066	1.00
184_Y	250_D	1.065	1.00
282_F	295_A	1.058	1.00
245_I	295_A	1.058	1.00
122_F	226_N	1.058	1.00
163_T	187_V	1.049	1.00
294_E	298_H	1.049	1.00
253_R	274_R	1.042	1.00
105_S	300_A	1.041	1.00
115_R	120_H	1.040	1.00
189_M	214_N	1.023	1.00
130_Y	172_N	1.015	1.00
117_A	120_H	1.011	1.00
248_E	277_G	1.006	1.00
248_E	274_R	1.005	1.00
190_L	233_L	1.002	1.00
115_R	124_T	0.999	1.00
82_H	116_L	0.998	1.00
74_N	146_D	0.989	1.00
160_N	164_V	0.985	1.00
80_Y	98_C	0.983	1.00
47_L	103_K	0.982	1.00
75_L	106_N	0.971	1.00
246_T	257_E	0.966	1.00
223_D	226_N	0.963	1.00
78_V	151_A	0.960	1.00
167_I	228_L	0.951	1.00
182_M	244_I	0.950	1.00
134_K	174_E	0.948	1.00
69_P	75_L	0.945	1.00
163_T	242_A	0.939	1.00
140_G	145_I	0.938	1.00
166_S	177_V	0.933	1.00
54_T	63_K	0.932	1.00
162_S	180_Q	0.929	1.00
122_F	217_Y	0.928	1.00
163_T	180_Q	0.920	1.00
51_R	68_F	0.917	1.00
258_M	262_K	0.916	1.00
188_N	233_L	0.915	1.00
194_P	198_N	0.914	1.00
152_V	165_V	0.913	1.00
76_P	107_T	0.912	1.00
67_Y	95_D	0.911	1.00
188_N	230_S	0.910	1.00
122_F	125_Q	0.907	1.00
86_F	157_A	0.904	1.00
122_F	228_L	0.902	1.00
133_V	169_D	0.897	1.00
125_Q	161_L	0.894	1.00
121_K	125_Q	0.892	1.00
55_I	62_I	0.887	1.00
67_Y	111_S	0.885	1.00
72_R	75_L	0.881	1.00
155_D	184_Y	0.879	1.00
244_I	259_Y	0.877	1.00
219_K	223_D	0.877	1.00
159_G	185_P	0.876	1.00
76_P	149_K	0.876	1.00
156_S	280_H	0.875	1.00
126_V	168_L	0.873	1.00
52_D	55_I	0.870	1.00
125_Q	217_Y	0.870	1.00
187_V	259_Y	0.869	1.00
281_G	284_S	0.868	1.00
140_G	147_T	0.865	1.00
160_N	217_Y	0.861	1.00
130_Y	165_V	0.860	1.00
168_L	171_D	0.853	1.00
81_Y	152_V	0.851	1.00
87_V	117_A	0.850	1.00
81_Y	165_V	0.850	1.00
181_I	303_I	0.849	1.00
263_L	270_T	0.848	1.00
243_L	298_H	0.845	1.00
197_Y	207_Y	0.844	1.00
245_I	273_L	0.843	1.00
149_K	178_K	0.839	1.00
56_P	61_D	0.836	1.00
220_E	223_D	0.834	1.00
56_P	60_G	0.834	1.00
137_A	150_I	0.833	1.00
275_Y	295_A	0.829	1.00
81_Y	162_S	0.828	1.00
44_K	47_L	0.828	1.00
129_A	161_L	0.828	1.00
49_N	68_F	0.826	1.00
246_T	253_R	0.818	1.00
166_S	242_A	0.793	1.00
271_I	302_S	0.791	1.00
186_V	210_I	0.790	1.00
186_V	214_N	0.790	1.00
45_V	103_K	0.787	1.00
197_Y	200_G	0.784	1.00
225_Y	233_L	0.783	1.00
98_C	102_S	0.781	1.00
97_V	283_V	0.781	1.00
64_V	135_W	0.778	1.00
121_K	124_T	0.773	1.00
236_S	262_K	0.767	1.00
117_A	125_Q	0.763	1.00
74_N	141_G	0.761	1.00
180_Q	239_L	0.760	1.00
76_P	146_D	0.758	1.00
298_H	301_S	0.758	1.00
140_G	143_L	0.751	1.00
90_N	116_L	0.749	1.00
247_A	282_F	0.747	1.00
206_T	209_R	0.747	1.00
236_S	266_S	0.747	1.00
278_M	282_F	0.746	1.00
77_A	150_I	0.745	1.00
84_G	89_G	0.744	1.00
293_K	297_H	0.743	1.00
209_R	213_Y	0.735	1.00
56_P	131_D	0.732	1.00
275_Y	278_M	0.730	1.00
203_Y	206_T	0.730	1.00
202_G	206_T	0.729	1.00
48_Y	102_S	0.719	1.00
195_S	198_N	0.717	1.00
302_S	305_K	0.714	1.00
219_K	224_Y	0.711	1.00
87_V	216_Q	0.710	1.00
52_D	91_L	0.710	1.00
188_N	191_D	0.709	1.00
245_I	275_Y	0.707	1.00
90_N	113_D	0.707	1.00
81_Y	133_V	0.706	1.00
130_Y	174_E	0.705	1.00
221_D	224_Y	0.704	1.00
157_A	161_L	0.703	1.00
183_I	283_V	0.703	1.00
68_F	75_L	0.703	1.00
139_N	143_L	0.700	1.00
80_Y	155_D	0.700	1.00
69_P	108_I	0.695	1.00
113_D	116_L	0.694	1.00
152_V	180_Q	0.688	1.00
164_V	228_L	0.683	1.00
80_Y	111_S	0.683	1.00
147_T	150_I	0.682	1.00
167_I	239_L	0.682	1.00
121_K	219_K	0.681	1.00
214_N	229_A	0.677	1.00
64_V	112_V	0.676	1.00
185_P	256_G	0.672	1.00
90_N	93_T	0.666	1.00
91_L	98_C	0.665	1.00
166_S	239_L	0.665	1.00
259_Y	263_L	0.663	1.00
135_W	143_L	0.660	1.00
301_S	305_K	0.658	1.00
47_L	70_N	0.657	1.00
191_D	211_L	0.655	1.00
186_V	189_M	0.654	1.00
155_D	283_V	0.651	1.00
287_E	293_K	0.651	1.00
50_I	53_M	0.649	1.00
242_A	259_Y	0.649	1.00
301_S	304_R	0.648	1.00
188_N	255_Q	0.647	1.00
200_G	203_Y	0.641	1.00
200_G	207_Y	0.636	1.00
205_L	210_I	0.635	1.00
117_A	123_P	0.631	1.00
257_E	261_H	0.630	1.00
126_V	165_V	0.630	1.00
159_G	187_V	0.626	1.00
120_H	125_Q	0.625	1.00
62_I	132_V	0.624	1.00
97_V	101_I	0.622	1.00
195_S	199_Y	0.619	1.00
140_G	144_S	0.618	1.00
184_Y	247_A	0.618	1.00
188_N	232_I	0.617	1.00
65_R	92_D	0.615	1.00
194_P	197_Y	0.615	1.00
169_D	174_E	0.614	1.00
300_A	304_R	0.614	1.00
43_E	46_G	0.613	1.00
97_V	296_I	0.613	1.00
65_R	111_S	0.612	1.00
243_L	271_I	0.610	1.00
226_N	229_A	0.609	1.00
88_Y	213_Y	0.606	1.00
133_V	150_I	0.606	1.00
193_S	258_M	0.604	1.00
222_S	225_Y	0.604	1.00
245_I	283_V	0.604	1.00
264_K	272_S	0.603	1.00
182_M	187_V	0.602	1.00
101_I	299_I	0.599	1.00
99_R	103_K	0.599	1.00
179_Y	303_I	0.598	1.00
56_P	62_I	0.597	1.00
55_I	64_V	0.597	1.00
141_G	147_T	0.597	1.00
79_V	165_V	0.596	1.00
166_S	240_P	0.595	1.00
292_G	296_I	0.592	1.00
112_V	129_A	0.589	1.00
153_A	183_I	0.588	1.00
75_L	144_S	0.584	1.00
155_D	183_I	0.582	1.00
62_I	112_V	0.582	1.00
233_L	236_S	0.581	1.00
53_M	142_K	0.580	1.00
151_A	178_K	0.579	1.00
294_E	297_H	0.579	1.00
211_L	215_K	0.578	1.00
71_Q	75_L	0.577	1.00
67_Y	91_L	0.575	1.00
247_A	278_M	0.575	1.00
85_G	213_Y	0.573	0.99
49_N	70_N	0.573	0.99
167_I	259_Y	0.572	0.99
176_V	240_P	0.571	0.99
167_I	170_R	0.570	0.99
131_D	134_K	0.569	0.99
94_H	97_V	0.568	0.99
53_M	56_P	0.568	0.99
238_N	268_V	0.567	0.99
239_L	259_Y	0.567	0.99
245_I	282_F	0.564	0.99
249_Y	277_G	0.564	0.99
248_E	253_R	0.563	0.99
137_A	174_E	0.562	0.99
127_Y	172_N	0.561	0.99
42_N	45_V	0.560	0.99
106_N	304_R	0.560	0.99
124_T	127_Y	0.560	0.99
199_Y	202_G	0.559	0.99
239_L	242_A	0.558	0.99
89_G	93_T	0.555	0.99
218_V	224_Y	0.555	0.99
208_E	211_L	0.553	0.99
203_Y	249_Y	0.550	0.99
51_R	54_T	0.547	0.99
180_Q	240_P	0.547	0.99
275_Y	283_V	0.545	0.99
170_R	239_L	0.545	0.99
192_S	197_Y	0.544	0.99
136_L	145_I	0.541	0.99
47_L	52_D	0.541	0.99
137_A	147_T	0.539	0.99
191_D	196_M	0.539	0.99
160_N	186_V	0.536	0.99
139_N	144_S	0.531	0.99
55_I	132_V	0.531	0.99
74_N	144_S	0.531	0.99
104_L	304_R	0.530	0.99
227_P	235_E	0.527	0.99
45_V	49_N	0.526	0.99
169_D	177_V	0.525	0.99
179_Y	241_P	0.523	0.99
89_G	116_L	0.523	0.99
100_L	296_I	0.520	0.99
52_D	63_K	0.518	0.99
55_I	135_W	0.518	0.99
123_P	127_Y	0.517	0.99
86_F	161_L	0.515	0.99
201_D	206_T	0.514	0.99
196_M	255_Q	0.511	0.99
87_V	212_W	0.510	0.99
137_A	175_N	0.507	0.99
78_V	109_I	0.507	0.99
100_L	103_K	0.506	0.99
278_M	289_L	0.504	0.99
230_S	234_A	0.504	0.99
152_V	177_V	0.503	0.99
188_N	258_M	0.500	0.99
125_Q	128_D	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zwqA	4	0.9904	100	0.302	Contact Map
2hm7A	2	0.9711	100	0.305	Contact Map
4wy8A	2	0.9839	100	0.308	Contact Map
2c7bA	3	0.9325	100	0.311	Contact Map
1lzlA	1	0.9807	100	0.316	Contact Map
3wj1A	4	0.9743	100	0.33	Contact Map
4wy5A	2	0.9936	100	0.36	Contact Map
4ob7A	2	0.9904	100	0.362	Contact Map
4xvcA	1	0.9486	100	0.367	Contact Map
3wj2A	4	0.9614	100	0.384	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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