GREMLIN Database
Q97VT8 - Lipase (LipP-2)
UniProt: Q97VT8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (263)
Sequences: 11755 (9187)
Seq/√Len: 566.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_R128_D4.0391.00
81_Y129_A3.6741.00
151_A179_Y3.2751.00
78_V153_A2.8561.00
273_L298_H2.8381.00
77_A145_I2.6661.00
257_E274_R2.5901.00
120_H124_T2.5691.00
139_N142_K2.4721.00
260_A270_T2.3491.00
133_V177_V2.3311.00
183_I299_I2.2921.00
260_A272_S2.2101.00
79_V132_V2.1671.00
86_F160_N2.1631.00
275_Y298_H2.1281.00
166_S180_Q2.1091.00
91_L113_D2.1051.00
135_W139_N2.0691.00
263_L268_V2.0601.00
246_T256_G2.0491.00
181_I299_I1.9771.00
179_Y302_S1.9641.00
110_V136_L1.9631.00
244_I260_A1.9491.00
257_E272_S1.9131.00
112_V132_V1.8831.00
66_V110_V1.8811.00
130_Y168_L1.8711.00
180_Q242_A1.8651.00
168_L172_N1.8511.00
242_A263_L1.8231.00
146_D149_K1.7881.00
104_L297_H1.7861.00
108_I145_I1.7601.00
80_Y153_A1.7581.00
163_T259_Y1.7511.00
129_A165_V1.7181.00
94_H155_D1.7041.00
95_D99_R1.7021.00
261_H265_V1.6981.00
182_M185_P1.6961.00
65_R91_L1.6681.00
246_T274_R1.6401.00
260_A264_K1.6341.00
248_E276_N1.6211.00
163_T182_M1.6081.00
68_F108_I1.6021.00
104_L300_A1.5941.00
77_A136_L1.5941.00
98_C109_I1.5781.00
151_A303_I1.5741.00
127_Y168_L1.5731.00
195_S254_D1.5641.00
100_L104_L1.5611.00
79_V133_V1.5511.00
168_L228_L1.5441.00
78_V107_T1.5401.00
170_R238_N1.5361.00
244_I256_G1.5331.00
264_K270_T1.5321.00
126_V164_V1.5301.00
153_A181_I1.5101.00
77_A110_V1.5051.00
75_L108_I1.4941.00
130_Y169_D1.4861.00
243_L273_L1.4461.00
152_V162_S1.4331.00
86_F186_V1.4181.00
212_W216_Q1.4131.00
114_Y157_A1.3911.00
246_T272_S1.3781.00
243_L302_S1.3771.00
64_V110_V1.3731.00
58_R131_D1.3681.00
189_M230_S1.3671.00
54_T61_D1.3411.00
179_Y243_L1.3361.00
262_K265_V1.3351.00
102_S109_I1.3351.00
184_Y281_G1.3321.00
262_K266_S1.3181.00
130_Y134_K1.3051.00
180_Q259_Y1.3021.00
53_M64_V1.2961.00
81_Y112_V1.2911.00
65_R95_D1.2891.00
241_P269_K1.2741.00
261_H264_K1.2621.00
79_V136_L1.2551.00
133_V165_V1.2451.00
66_V108_I1.2401.00
64_V132_V1.2211.00
253_R257_E1.2031.00
80_Y94_H1.2011.00
297_H301_S1.1981.00
167_I234_A1.1951.00
271_I298_H1.1921.00
63_K113_D1.1891.00
122_F229_A1.1871.00
289_L292_G1.1781.00
98_C111_S1.1771.00
271_I305_K1.1761.00
184_Y283_V1.1751.00
258_M261_H1.1671.00
134_K138_N1.1641.00
77_A108_I1.1531.00
53_M66_V1.1491.00
218_V229_A1.1461.00
52_D65_R1.1271.00
124_T128_D1.1221.00
278_M291_T1.1101.00
291_T294_E1.0921.00
134_K172_N1.0851.00
198_N253_R1.0851.00
171_D228_L1.0841.00
275_Y282_F1.0781.00
230_S233_L1.0781.00
133_V137_A1.0751.00
207_Y211_L1.0731.00
162_S182_M1.0671.00
254_D257_E1.0661.00
184_Y250_D1.0651.00
282_F295_A1.0581.00
245_I295_A1.0581.00
122_F226_N1.0581.00
163_T187_V1.0491.00
294_E298_H1.0491.00
253_R274_R1.0421.00
105_S300_A1.0411.00
115_R120_H1.0401.00
189_M214_N1.0231.00
130_Y172_N1.0151.00
117_A120_H1.0111.00
248_E277_G1.0061.00
248_E274_R1.0051.00
190_L233_L1.0021.00
115_R124_T0.9991.00
82_H116_L0.9981.00
74_N146_D0.9891.00
160_N164_V0.9851.00
80_Y98_C0.9831.00
47_L103_K0.9821.00
75_L106_N0.9711.00
246_T257_E0.9661.00
223_D226_N0.9631.00
78_V151_A0.9601.00
167_I228_L0.9511.00
182_M244_I0.9501.00
134_K174_E0.9481.00
69_P75_L0.9451.00
163_T242_A0.9391.00
140_G145_I0.9381.00
166_S177_V0.9331.00
54_T63_K0.9321.00
162_S180_Q0.9291.00
122_F217_Y0.9281.00
163_T180_Q0.9201.00
51_R68_F0.9171.00
258_M262_K0.9161.00
188_N233_L0.9151.00
194_P198_N0.9141.00
152_V165_V0.9131.00
76_P107_T0.9121.00
67_Y95_D0.9111.00
188_N230_S0.9101.00
122_F125_Q0.9071.00
86_F157_A0.9041.00
122_F228_L0.9021.00
133_V169_D0.8971.00
125_Q161_L0.8941.00
121_K125_Q0.8921.00
55_I62_I0.8871.00
67_Y111_S0.8851.00
72_R75_L0.8811.00
155_D184_Y0.8791.00
244_I259_Y0.8771.00
219_K223_D0.8771.00
159_G185_P0.8761.00
76_P149_K0.8761.00
156_S280_H0.8751.00
126_V168_L0.8731.00
52_D55_I0.8701.00
125_Q217_Y0.8701.00
187_V259_Y0.8691.00
281_G284_S0.8681.00
140_G147_T0.8651.00
160_N217_Y0.8611.00
130_Y165_V0.8601.00
168_L171_D0.8531.00
81_Y152_V0.8511.00
87_V117_A0.8501.00
81_Y165_V0.8501.00
181_I303_I0.8491.00
263_L270_T0.8481.00
243_L298_H0.8451.00
197_Y207_Y0.8441.00
245_I273_L0.8431.00
149_K178_K0.8391.00
56_P61_D0.8361.00
220_E223_D0.8341.00
56_P60_G0.8341.00
137_A150_I0.8331.00
275_Y295_A0.8291.00
81_Y162_S0.8281.00
44_K47_L0.8281.00
129_A161_L0.8281.00
49_N68_F0.8261.00
246_T253_R0.8181.00
166_S242_A0.7931.00
271_I302_S0.7911.00
186_V210_I0.7901.00
186_V214_N0.7901.00
45_V103_K0.7871.00
197_Y200_G0.7841.00
225_Y233_L0.7831.00
98_C102_S0.7811.00
97_V283_V0.7811.00
64_V135_W0.7781.00
121_K124_T0.7731.00
236_S262_K0.7671.00
117_A125_Q0.7631.00
74_N141_G0.7611.00
180_Q239_L0.7601.00
76_P146_D0.7581.00
298_H301_S0.7581.00
140_G143_L0.7511.00
90_N116_L0.7491.00
247_A282_F0.7471.00
206_T209_R0.7471.00
236_S266_S0.7471.00
278_M282_F0.7461.00
77_A150_I0.7451.00
84_G89_G0.7441.00
293_K297_H0.7431.00
209_R213_Y0.7351.00
56_P131_D0.7321.00
275_Y278_M0.7301.00
203_Y206_T0.7301.00
202_G206_T0.7291.00
48_Y102_S0.7191.00
195_S198_N0.7171.00
302_S305_K0.7141.00
219_K224_Y0.7111.00
87_V216_Q0.7101.00
52_D91_L0.7101.00
188_N191_D0.7091.00
245_I275_Y0.7071.00
90_N113_D0.7071.00
81_Y133_V0.7061.00
130_Y174_E0.7051.00
221_D224_Y0.7041.00
157_A161_L0.7031.00
183_I283_V0.7031.00
68_F75_L0.7031.00
139_N143_L0.7001.00
80_Y155_D0.7001.00
69_P108_I0.6951.00
113_D116_L0.6941.00
152_V180_Q0.6881.00
164_V228_L0.6831.00
80_Y111_S0.6831.00
147_T150_I0.6821.00
167_I239_L0.6821.00
121_K219_K0.6811.00
214_N229_A0.6771.00
64_V112_V0.6761.00
185_P256_G0.6721.00
90_N93_T0.6661.00
91_L98_C0.6651.00
166_S239_L0.6651.00
259_Y263_L0.6631.00
135_W143_L0.6601.00
301_S305_K0.6581.00
47_L70_N0.6571.00
191_D211_L0.6551.00
186_V189_M0.6541.00
155_D283_V0.6511.00
287_E293_K0.6511.00
50_I53_M0.6491.00
242_A259_Y0.6491.00
301_S304_R0.6481.00
188_N255_Q0.6471.00
200_G203_Y0.6411.00
200_G207_Y0.6361.00
205_L210_I0.6351.00
117_A123_P0.6311.00
257_E261_H0.6301.00
126_V165_V0.6301.00
159_G187_V0.6261.00
120_H125_Q0.6251.00
62_I132_V0.6241.00
97_V101_I0.6221.00
195_S199_Y0.6191.00
140_G144_S0.6181.00
184_Y247_A0.6181.00
188_N232_I0.6171.00
65_R92_D0.6151.00
194_P197_Y0.6151.00
169_D174_E0.6141.00
300_A304_R0.6141.00
43_E46_G0.6131.00
97_V296_I0.6131.00
65_R111_S0.6121.00
243_L271_I0.6101.00
226_N229_A0.6091.00
88_Y213_Y0.6061.00
133_V150_I0.6061.00
193_S258_M0.6041.00
222_S225_Y0.6041.00
245_I283_V0.6041.00
264_K272_S0.6031.00
182_M187_V0.6021.00
101_I299_I0.5991.00
99_R103_K0.5991.00
179_Y303_I0.5981.00
56_P62_I0.5971.00
55_I64_V0.5971.00
141_G147_T0.5971.00
79_V165_V0.5961.00
166_S240_P0.5951.00
292_G296_I0.5921.00
112_V129_A0.5891.00
153_A183_I0.5881.00
75_L144_S0.5841.00
155_D183_I0.5821.00
62_I112_V0.5821.00
233_L236_S0.5811.00
53_M142_K0.5801.00
151_A178_K0.5791.00
294_E297_H0.5791.00
211_L215_K0.5781.00
71_Q75_L0.5771.00
67_Y91_L0.5751.00
247_A278_M0.5751.00
85_G213_Y0.5730.99
49_N70_N0.5730.99
167_I259_Y0.5720.99
176_V240_P0.5710.99
167_I170_R0.5700.99
131_D134_K0.5690.99
94_H97_V0.5680.99
53_M56_P0.5680.99
238_N268_V0.5670.99
239_L259_Y0.5670.99
245_I282_F0.5640.99
249_Y277_G0.5640.99
248_E253_R0.5630.99
137_A174_E0.5620.99
127_Y172_N0.5610.99
42_N45_V0.5600.99
106_N304_R0.5600.99
124_T127_Y0.5600.99
199_Y202_G0.5590.99
239_L242_A0.5580.99
89_G93_T0.5550.99
218_V224_Y0.5550.99
208_E211_L0.5530.99
203_Y249_Y0.5500.99
51_R54_T0.5470.99
180_Q240_P0.5470.99
275_Y283_V0.5450.99
170_R239_L0.5450.99
192_S197_Y0.5440.99
136_L145_I0.5410.99
47_L52_D0.5410.99
137_A147_T0.5390.99
191_D196_M0.5390.99
160_N186_V0.5360.99
139_N144_S0.5310.99
55_I132_V0.5310.99
74_N144_S0.5310.99
104_L304_R0.5300.99
227_P235_E0.5270.99
45_V49_N0.5260.99
169_D177_V0.5250.99
179_Y241_P0.5230.99
89_G116_L0.5230.99
100_L296_I0.5200.99
52_D63_K0.5180.99
55_I135_W0.5180.99
123_P127_Y0.5170.99
86_F161_L0.5150.99
201_D206_T0.5140.99
196_M255_Q0.5110.99
87_V212_W0.5100.99
137_A175_N0.5070.99
78_V109_I0.5070.99
100_L103_K0.5060.99
278_M289_L0.5040.99
230_S234_A0.5040.99
152_V177_V0.5030.99
188_N258_M0.5000.99
125_Q128_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwqA 4 0.9904 100 0.302 Contact Map
2hm7A 2 0.9711 100 0.305 Contact Map
4wy8A 2 0.9839 100 0.308 Contact Map
2c7bA 3 0.9325 100 0.311 Contact Map
1lzlA 1 0.9807 100 0.316 Contact Map
3wj1A 4 0.9743 100 0.33 Contact Map
4wy5A 2 0.9936 100 0.36 Contact Map
4ob7A 2 0.9904 100 0.362 Contact Map
4xvcA 1 0.9486 100 0.367 Contact Map
3wj2A 4 0.9614 100 0.384 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0201 seconds.