GREMLIN Database
PHP - Aryldialkylphosphatase
UniProt: Q97VT7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (299)
Sequences: 936 (656)
Seq/√Len: 37.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_A61_V3.8581.00
292_K298_E3.6701.00
182_Q217_S3.4541.00
297_N300_V3.1851.00
160_N190_V3.0921.00
81_K85_A2.9471.00
119_I159_A2.9411.00
80_E84_K2.9001.00
183_R215_K2.8781.00
5_L10_S2.8111.00
120_H124_E2.7971.00
169_T181_Q2.7771.00
210_K245_D2.6721.00
133_A165_V2.6571.00
298_E302_A2.6351.00
302_A306_K2.6011.00
248_S303_T2.5311.00
154_R188_E2.5271.00
122_I165_V2.4471.00
224_Y287_T2.4301.00
137_K140_A2.4231.00
288_I292_K2.3971.00
249_D303_T2.3921.00
57_M62_K2.3891.00
150_E154_R2.3711.00
302_A307_E2.2200.99
147_K150_E2.1850.99
50_V86_T2.1770.99
186_T215_K2.1410.99
119_I163_T2.1270.99
91_V134_G2.1210.99
59_F285_E2.0830.99
136_V156_A2.0650.99
115_A119_I2.0350.99
46_F81_K2.0350.99
168_I198_G2.0300.99
63_T89_N2.0290.99
211_K214_D1.9740.99
253_I304_I1.9610.98
170_H256_D1.8870.98
186_T192_P1.8790.98
16_I63_T1.8770.98
119_I162_E1.8730.98
241_R244_K1.8660.98
115_A158_I1.7880.97
8_K89_N1.7850.97
307_E310_K1.7640.97
243_I296_V1.7530.97
158_I188_E1.7510.97
192_P195_I1.7360.97
240_L244_K1.7350.97
196_L312_F1.7020.96
218_F252_M1.6900.96
140_A181_Q1.6900.96
237_E294_N1.6730.96
199_H256_D1.6560.96
54_K57_M1.6360.95
241_R245_D1.6010.95
53_V82_V1.6010.95
4_P63_T1.5950.95
248_S300_V1.5710.94
114_I155_A1.5680.94
170_H199_H1.5620.94
50_V85_A1.5540.94
288_I305_F1.5240.93
54_K58_Q1.5170.93
178_G212_I1.4960.92
179_L211_K1.4900.92
135_F168_I1.4770.92
303_T307_E1.4670.92
214_D247_Y1.4240.90
160_N167_I1.4230.90
179_L215_K1.4120.90
157_A185_L1.4020.90
276_P279_S1.3780.89
154_R158_I1.3720.89
183_R187_E1.3630.88
99_Y146_T1.3610.88
25_L90_L1.3610.88
4_P11_I1.3540.88
291_L296_V1.3400.88
12_E15_D1.3200.87
243_I251_I1.3120.86
47_R85_A1.3120.86
139_A142_E1.3070.86
281_T285_E1.3000.86
182_Q197_I1.3000.86
182_Q215_K1.2950.86
243_I248_S1.2940.86
61_V284_F1.2900.85
296_V300_V1.2880.85
18_F284_F1.2820.85
218_F311_K1.2740.85
67_P93_G1.2570.84
52_E276_P1.2510.84
21_I252_M1.2420.83
169_T197_I1.2360.83
116_D120_H1.2320.83
59_F284_F1.2000.81
127_Q130_L1.1970.81
236_N290_F1.1850.80
181_Q197_I1.1830.80
121_D133_A1.1830.80
19_T63_T1.1770.80
111_I158_I1.1770.80
92_A126_I1.1750.80
67_P168_I1.1710.79
19_T109_R1.1550.78
225_G232_V1.1550.78
251_I304_I1.1450.78
243_I304_I1.1440.78
56_A88_I1.1350.77
140_A169_T1.1310.77
50_V82_V1.1190.76
154_R187_E1.1140.76
74_R121_D1.1040.75
5_L132_K1.0980.75
218_F308_N1.0970.75
236_N294_N1.0900.74
178_G208_Y1.0860.74
155_A159_A1.0760.73
25_L53_V1.0710.73
138_I142_E1.0670.73
126_I129_T1.0600.72
250_K311_K1.0560.72
106_F151_K1.0550.72
213_A247_Y1.0480.71
80_E130_L1.0470.71
30_E33_R1.0380.70
159_A165_V1.0280.70
126_I130_L1.0270.70
248_S296_V1.0200.69
296_V304_I1.0200.69
222_D256_D1.0190.69
75_D78_F1.0170.69
252_M308_N1.0150.69
137_K142_E1.0150.69
122_I133_A1.0130.69
76_I79_M1.0100.68
20_L284_F1.0050.68
171_S181_Q1.0030.68
210_K214_D1.0000.68
21_I305_F0.9970.67
11_I19_T0.9940.67
53_V86_T0.9930.67
109_R113_E0.9910.67
211_K215_K0.9910.67
8_K84_K0.9900.67
16_I310_K0.9840.66
150_E188_E0.9820.66
47_R50_V0.9780.66
169_T185_L0.9710.65
20_L254_S0.9560.64
185_L190_V0.9560.64
138_I156_A0.9540.64
252_M312_F0.9530.64
204_D234_K0.9510.64
52_E279_S0.9510.64
120_H123_K0.9510.64
33_R39_L0.9410.63
79_M92_A0.9380.63
199_H222_D0.9330.62
218_F312_F0.9330.62
70_M96_I0.9280.62
145_I180_E0.9220.61
80_E131_N0.9150.61
209_I221_L0.9100.60
81_K132_K0.9040.60
69_V137_K0.9030.60
7_G134_G0.9020.59
22_H256_D0.9000.59
221_L242_L0.8990.59
96_I105_Y0.8990.59
23_E254_S0.8980.59
182_Q192_P0.8980.59
150_E184_I0.8950.59
94_T118_F0.8940.59
212_I217_S0.8900.58
97_Y255_H0.8890.58
41_N44_E0.8880.58
202_D223_R0.8860.58
170_H222_D0.8860.58
32_V39_L0.8860.58
184_I188_E0.8830.58
134_G165_V0.8800.58
110_S113_E0.8790.57
53_V88_I0.8740.57
76_I126_I0.8740.57
13_S313_F0.8720.57
167_I198_G0.8720.57
161_K188_E0.8710.57
182_Q186_T0.8660.56
258_C262_D0.8560.55
18_F61_V0.8560.55
76_I128_G0.8500.55
284_F288_I0.8490.55
137_K141_D0.8450.54
223_R258_C0.8450.54
282_L287_T0.8430.54
158_I161_K0.8400.54
76_I92_A0.8350.54
55_R59_F0.8350.54
19_T89_N0.8340.53
201_G223_R0.8320.53
124_E133_A0.8310.53
93_G137_K0.8280.53
203_T209_I0.8220.52
29_S32_V0.8170.52
167_I185_L0.8140.52
58_Q116_D0.8140.52
69_V253_I0.8080.51
94_T121_D0.8040.51
21_I65_V0.8030.51
201_G235_R0.8020.51
161_K190_V0.7970.50
46_F82_V0.7960.50
200_L212_I0.7950.50
96_I114_I0.7920.50
3_I10_S0.7880.49
34_Q39_L0.7870.49
91_V191_D0.7860.49
66_D195_I0.7840.49
29_S72_L0.7840.49
299_E307_E0.7790.49
26_R78_F0.7790.49
177_T180_E0.7780.48
61_V88_I0.7780.48
123_K162_E0.7780.48
11_I16_I0.7750.48
74_R125_G0.7730.48
111_I115_A0.7720.48
136_V160_N0.7620.47
91_V281_T0.7610.47
252_M304_I0.7600.47
260_T279_S0.7590.47
186_T195_I0.7550.46
33_R37_P0.7550.46
57_M88_I0.7540.46
278_W282_L0.7510.46
24_H170_H0.7510.46
288_I301_I0.7500.46
141_D149_V0.7480.46
54_K86_T0.7430.45
17_G60_G0.7370.45
145_I184_I0.7330.44
26_R82_V0.7330.44
65_V86_T0.7330.44
166_P312_F0.7310.44
22_H170_H0.7300.44
184_I187_E0.7290.44
66_D208_Y0.7290.44
97_Y256_D0.7280.44
18_F305_F0.7260.44
24_H256_D0.7230.44
65_V91_V0.7210.43
137_K256_D0.7200.43
52_E277_R0.7180.43
3_I11_I0.7180.43
172_N175_N0.7160.43
137_K257_Y0.7150.43
242_L251_I0.7150.43
201_G276_P0.7150.43
118_F156_A0.7140.43
24_H199_H0.7130.43
67_P135_F0.7110.43
169_T195_I0.7100.42
150_E180_E0.7090.42
209_I238_T0.7090.42
4_P16_I0.7080.42
52_E280_I0.7020.42
4_P13_S0.7020.42
11_I75_D0.7010.42
201_G313_F0.6990.42
226_L229_F0.6960.41
153_I219_I0.6960.41
122_I159_A0.6960.41
62_K89_N0.6950.41
81_K251_I0.6940.41
9_D16_I0.6930.41
145_I177_T0.6910.41
206_I241_R0.6880.41
168_I220_G0.6870.40
113_E116_D0.6870.40
67_P198_G0.6870.40
257_Y276_P0.6870.40
27_V258_C0.6860.40
23_E225_G0.6860.40
240_L243_I0.6840.40
69_V97_Y0.6820.40
141_D172_N0.6810.40
289_P292_K0.6810.40
97_Y226_L0.6800.40
55_R264_G0.6760.40
112_D116_D0.6750.39
15_D304_I0.6750.39
46_F78_F0.6730.39
169_T213_A0.6710.39
6_V9_D0.6710.39
255_H283_I0.6690.39
243_I300_V0.6680.39
11_I15_D0.6640.39
87_G90_L0.6630.38
257_Y263_W0.6600.38
263_W276_P0.6590.38
205_N208_Y0.6590.38
45_E49_A0.6590.38
143_P177_T0.6580.38
119_I123_K0.6580.38
102_L114_I0.6570.38
102_L172_N0.6560.38
135_F169_T0.6560.38
22_H199_H0.6560.38
18_F302_A0.6540.38
292_K301_I0.6540.38
196_L220_G0.6530.38
93_G135_F0.6530.38
140_A200_L0.6480.37
190_V194_K0.6480.37
7_G131_N0.6460.37
68_T128_G0.6460.37
171_S197_I0.6450.37
28_F103_P0.6430.37
187_E194_K0.6420.37
16_I123_K0.6400.37
111_I154_R0.6390.36
226_L259_C0.6380.36
141_D153_I0.6360.36
153_I169_T0.6340.36
154_R184_I0.6340.36
71_G97_Y0.6340.36
152_V165_V0.6300.36
183_R197_I0.6300.36
77_R90_L0.6300.36
160_N217_S0.6290.36
118_F159_A0.6280.36
218_F250_K0.6270.35
83_V88_I0.6260.35
15_D89_N0.6210.35
219_I238_T0.6200.35
96_I117_L0.6190.35
224_Y282_L0.6180.35
61_V283_I0.6150.34
4_P34_Q0.6140.34
173_A282_L0.6140.34
306_K310_K0.6130.34
25_L79_M0.6120.34
20_L255_H0.6110.34
171_S313_F0.6090.34
239_T296_V0.6090.34
185_L195_I0.6080.34
240_L296_V0.6050.34
128_G185_L0.6050.34
6_V11_I0.6030.33
121_D184_I0.5990.33
192_P217_S0.5980.33
172_N202_D0.5970.33
259_C262_D0.5960.33
75_D311_K0.5950.33
176_N211_K0.5950.33
111_I151_K0.5940.33
50_V54_K0.5940.33
94_T126_I0.5930.33
260_T270_Y0.5930.33
224_Y227_D0.5910.33
94_T133_A0.5910.33
234_K237_E0.5890.32
26_R49_A0.5890.32
249_D311_K0.5840.32
112_D162_E0.5840.32
185_L192_P0.5830.32
109_R117_L0.5820.32
20_L23_E0.5810.32
45_E52_E0.5810.32
257_Y313_F0.5780.32
225_G254_S0.5780.32
76_I127_Q0.5780.32
202_D259_C0.5770.31
88_I207_D0.5770.31
27_V72_L0.5750.31
56_A59_F0.5720.31
93_G258_C0.5700.31
232_V282_L0.5690.31
191_D245_D0.5680.31
260_T277_R0.5650.31
161_K250_K0.5650.31
179_L212_I0.5640.30
72_L97_Y0.5640.30
140_A145_I0.5600.30
14_K237_E0.5600.30
194_K292_K0.5590.30
249_D293_R0.5590.30
237_E298_E0.5590.30
4_P91_V0.5570.30
168_I196_L0.5560.30
239_T284_F0.5550.30
195_I198_G0.5540.30
221_L287_T0.5530.30
136_V159_A0.5510.29
20_L56_A0.5490.29
93_G152_V0.5480.29
8_K133_A0.5470.29
137_K170_H0.5470.29
73_G205_N0.5460.29
150_E158_I0.5460.29
116_D147_K0.5410.29
252_M290_F0.5410.29
221_L251_I0.5380.29
11_I62_K0.5380.29
213_A217_S0.5360.28
84_K130_L0.5340.28
64_I280_I0.5330.28
115_A159_A0.5320.28
121_D166_P0.5310.28
8_K87_G0.5300.28
251_I303_T0.5250.28
70_M117_L0.5220.27
224_Y235_R0.5190.27
74_R222_D0.5190.27
183_R211_K0.5190.27
65_V122_I0.5180.27
167_I190_V0.5170.27
4_P19_T0.5160.27
140_A153_I0.5160.27
74_R136_V0.5120.27
198_G262_D0.5120.27
229_F259_C0.5110.27
57_M284_F0.5100.27
230_L234_K0.5100.27
111_I188_E0.5090.26
118_F139_A0.5080.26
143_P176_N0.5080.26
91_V116_D0.5070.26
202_D262_D0.5060.26
119_I191_D0.5060.26
141_D169_T0.5060.26
171_S203_T0.5050.26
11_I89_N0.5050.26
179_L182_Q0.5050.26
35_Q39_L0.5040.26
133_A163_T0.5040.26
248_S251_I0.5030.26
27_V103_P0.5030.26
11_I63_T0.5020.26
36_W39_L0.5020.26
190_V195_I0.5010.26
103_P106_F0.5010.26
71_G131_N0.5010.26
191_D310_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k2gA 3 0.9682 100 0.422 Contact Map
3rhgA 2 0.965 100 0.439 Contact Map
3pnzA 4 0.965 100 0.548 Contact Map
3gtxA 2 0.9936 100 0.571 Contact Map
4if2A 2 0.9904 100 0.573 Contact Map
3tn4A 2 0.9936 100 0.573 Contact Map
3ovgA 4 0.9745 100 0.583 Contact Map
2ob3A 2 0.9682 100 0.591 Contact Map
4kezA 2 1 100 0.604 Contact Map
1bf6A 1 0.9236 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.