PHP - SULSO - GREMLIN Contacts

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PHP - Aryldialkylphosphatase

UniProt:	Q97VT7	Sequences: MRIPLVGKDSIESKDIGFTLIHEHLRVFSEAVRQQWPHLYNEDEEFRNAVNEVKRAMQFGVKTIVDPTVMGLGRDIRFMEKVVKATGINLVAGTGIYIYIDLPFYFLNRSIDEIADLFIHDIKEGIQGTLNKAGFVKIAADEPGITKDVEKVIRAAAIANKETKVPIITHSNAHNNTGLEQQRILTEEGVDPGKILIGHLGDTDNIDYIKKIADKGSFIGLDRYGLDLFLPVDKRNETTLRLIKDGYSDKIMISHDYCCTIDWGTAKPEYKPKLAPRWSITLIFEDTIPFLKRNGVNEEVIATIFKENPKKFFS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	314 (299)
Sequences:	936 (656)
Seq/√Len:	37.9

ECOLI - PHP
SULSO - PHP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_A	61_V	3.858	1.00
292_K	298_E	3.670	1.00
182_Q	217_S	3.454	1.00
297_N	300_V	3.185	1.00
160_N	190_V	3.092	1.00
81_K	85_A	2.947	1.00
119_I	159_A	2.941	1.00
80_E	84_K	2.900	1.00
183_R	215_K	2.878	1.00
5_L	10_S	2.811	1.00
120_H	124_E	2.797	1.00
169_T	181_Q	2.777	1.00
210_K	245_D	2.672	1.00
133_A	165_V	2.657	1.00
298_E	302_A	2.635	1.00
302_A	306_K	2.601	1.00
248_S	303_T	2.531	1.00
154_R	188_E	2.527	1.00
122_I	165_V	2.447	1.00
224_Y	287_T	2.430	1.00
137_K	140_A	2.423	1.00
288_I	292_K	2.397	1.00
249_D	303_T	2.392	1.00
57_M	62_K	2.389	1.00
150_E	154_R	2.371	1.00
302_A	307_E	2.220	0.99
147_K	150_E	2.185	0.99
50_V	86_T	2.177	0.99
186_T	215_K	2.141	0.99
119_I	163_T	2.127	0.99
91_V	134_G	2.121	0.99
59_F	285_E	2.083	0.99
136_V	156_A	2.065	0.99
115_A	119_I	2.035	0.99
46_F	81_K	2.035	0.99
168_I	198_G	2.030	0.99
63_T	89_N	2.029	0.99
211_K	214_D	1.974	0.99
253_I	304_I	1.961	0.98
170_H	256_D	1.887	0.98
186_T	192_P	1.879	0.98
16_I	63_T	1.877	0.98
119_I	162_E	1.873	0.98
241_R	244_K	1.866	0.98
115_A	158_I	1.788	0.97
8_K	89_N	1.785	0.97
307_E	310_K	1.764	0.97
243_I	296_V	1.753	0.97
158_I	188_E	1.751	0.97
192_P	195_I	1.736	0.97
240_L	244_K	1.735	0.97
196_L	312_F	1.702	0.96
218_F	252_M	1.690	0.96
140_A	181_Q	1.690	0.96
237_E	294_N	1.673	0.96
199_H	256_D	1.656	0.96
54_K	57_M	1.636	0.95
241_R	245_D	1.601	0.95
53_V	82_V	1.601	0.95
4_P	63_T	1.595	0.95
248_S	300_V	1.571	0.94
114_I	155_A	1.568	0.94
170_H	199_H	1.562	0.94
50_V	85_A	1.554	0.94
288_I	305_F	1.524	0.93
54_K	58_Q	1.517	0.93
178_G	212_I	1.496	0.92
179_L	211_K	1.490	0.92
135_F	168_I	1.477	0.92
303_T	307_E	1.467	0.92
214_D	247_Y	1.424	0.90
160_N	167_I	1.423	0.90
179_L	215_K	1.412	0.90
157_A	185_L	1.402	0.90
276_P	279_S	1.378	0.89
154_R	158_I	1.372	0.89
183_R	187_E	1.363	0.88
99_Y	146_T	1.361	0.88
25_L	90_L	1.361	0.88
4_P	11_I	1.354	0.88
291_L	296_V	1.340	0.88
12_E	15_D	1.320	0.87
243_I	251_I	1.312	0.86
47_R	85_A	1.312	0.86
139_A	142_E	1.307	0.86
281_T	285_E	1.300	0.86
182_Q	197_I	1.300	0.86
182_Q	215_K	1.295	0.86
243_I	248_S	1.294	0.86
61_V	284_F	1.290	0.85
296_V	300_V	1.288	0.85
18_F	284_F	1.282	0.85
218_F	311_K	1.274	0.85
67_P	93_G	1.257	0.84
52_E	276_P	1.251	0.84
21_I	252_M	1.242	0.83
169_T	197_I	1.236	0.83
116_D	120_H	1.232	0.83
59_F	284_F	1.200	0.81
127_Q	130_L	1.197	0.81
236_N	290_F	1.185	0.80
181_Q	197_I	1.183	0.80
121_D	133_A	1.183	0.80
19_T	63_T	1.177	0.80
111_I	158_I	1.177	0.80
92_A	126_I	1.175	0.80
67_P	168_I	1.171	0.79
19_T	109_R	1.155	0.78
225_G	232_V	1.155	0.78
251_I	304_I	1.145	0.78
243_I	304_I	1.144	0.78
56_A	88_I	1.135	0.77
140_A	169_T	1.131	0.77
50_V	82_V	1.119	0.76
154_R	187_E	1.114	0.76
74_R	121_D	1.104	0.75
5_L	132_K	1.098	0.75
218_F	308_N	1.097	0.75
236_N	294_N	1.090	0.74
178_G	208_Y	1.086	0.74
155_A	159_A	1.076	0.73
25_L	53_V	1.071	0.73
138_I	142_E	1.067	0.73
126_I	129_T	1.060	0.72
250_K	311_K	1.056	0.72
106_F	151_K	1.055	0.72
213_A	247_Y	1.048	0.71
80_E	130_L	1.047	0.71
30_E	33_R	1.038	0.70
159_A	165_V	1.028	0.70
126_I	130_L	1.027	0.70
248_S	296_V	1.020	0.69
296_V	304_I	1.020	0.69
222_D	256_D	1.019	0.69
75_D	78_F	1.017	0.69
252_M	308_N	1.015	0.69
137_K	142_E	1.015	0.69
122_I	133_A	1.013	0.69
76_I	79_M	1.010	0.68
20_L	284_F	1.005	0.68
171_S	181_Q	1.003	0.68
210_K	214_D	1.000	0.68
21_I	305_F	0.997	0.67
11_I	19_T	0.994	0.67
53_V	86_T	0.993	0.67
109_R	113_E	0.991	0.67
211_K	215_K	0.991	0.67
8_K	84_K	0.990	0.67
16_I	310_K	0.984	0.66
150_E	188_E	0.982	0.66
47_R	50_V	0.978	0.66
169_T	185_L	0.971	0.65
20_L	254_S	0.956	0.64
185_L	190_V	0.956	0.64
138_I	156_A	0.954	0.64
252_M	312_F	0.953	0.64
204_D	234_K	0.951	0.64
52_E	279_S	0.951	0.64
120_H	123_K	0.951	0.64
33_R	39_L	0.941	0.63
79_M	92_A	0.938	0.63
199_H	222_D	0.933	0.62
218_F	312_F	0.933	0.62
70_M	96_I	0.928	0.62
145_I	180_E	0.922	0.61
80_E	131_N	0.915	0.61
209_I	221_L	0.910	0.60
81_K	132_K	0.904	0.60
69_V	137_K	0.903	0.60
7_G	134_G	0.902	0.59
22_H	256_D	0.900	0.59
221_L	242_L	0.899	0.59
96_I	105_Y	0.899	0.59
23_E	254_S	0.898	0.59
182_Q	192_P	0.898	0.59
150_E	184_I	0.895	0.59
94_T	118_F	0.894	0.59
212_I	217_S	0.890	0.58
97_Y	255_H	0.889	0.58
41_N	44_E	0.888	0.58
202_D	223_R	0.886	0.58
170_H	222_D	0.886	0.58
32_V	39_L	0.886	0.58
184_I	188_E	0.883	0.58
134_G	165_V	0.880	0.58
110_S	113_E	0.879	0.57
53_V	88_I	0.874	0.57
76_I	126_I	0.874	0.57
13_S	313_F	0.872	0.57
167_I	198_G	0.872	0.57
161_K	188_E	0.871	0.57
182_Q	186_T	0.866	0.56
258_C	262_D	0.856	0.55
18_F	61_V	0.856	0.55
76_I	128_G	0.850	0.55
284_F	288_I	0.849	0.55
137_K	141_D	0.845	0.54
223_R	258_C	0.845	0.54
282_L	287_T	0.843	0.54
158_I	161_K	0.840	0.54
76_I	92_A	0.835	0.54
55_R	59_F	0.835	0.54
19_T	89_N	0.834	0.53
201_G	223_R	0.832	0.53
124_E	133_A	0.831	0.53
93_G	137_K	0.828	0.53
203_T	209_I	0.822	0.52
29_S	32_V	0.817	0.52
167_I	185_L	0.814	0.52
58_Q	116_D	0.814	0.52
69_V	253_I	0.808	0.51
94_T	121_D	0.804	0.51
21_I	65_V	0.803	0.51
201_G	235_R	0.802	0.51
161_K	190_V	0.797	0.50
46_F	82_V	0.796	0.50
200_L	212_I	0.795	0.50
96_I	114_I	0.792	0.50
3_I	10_S	0.788	0.49
34_Q	39_L	0.787	0.49
91_V	191_D	0.786	0.49
66_D	195_I	0.784	0.49
29_S	72_L	0.784	0.49
299_E	307_E	0.779	0.49
26_R	78_F	0.779	0.49
177_T	180_E	0.778	0.48
61_V	88_I	0.778	0.48
123_K	162_E	0.778	0.48
11_I	16_I	0.775	0.48
74_R	125_G	0.773	0.48
111_I	115_A	0.772	0.48
136_V	160_N	0.762	0.47
91_V	281_T	0.761	0.47
252_M	304_I	0.760	0.47
260_T	279_S	0.759	0.47
186_T	195_I	0.755	0.46
33_R	37_P	0.755	0.46
57_M	88_I	0.754	0.46
278_W	282_L	0.751	0.46
24_H	170_H	0.751	0.46
288_I	301_I	0.750	0.46
141_D	149_V	0.748	0.46
54_K	86_T	0.743	0.45
17_G	60_G	0.737	0.45
145_I	184_I	0.733	0.44
26_R	82_V	0.733	0.44
65_V	86_T	0.733	0.44
166_P	312_F	0.731	0.44
22_H	170_H	0.730	0.44
184_I	187_E	0.729	0.44
66_D	208_Y	0.729	0.44
97_Y	256_D	0.728	0.44
18_F	305_F	0.726	0.44
24_H	256_D	0.723	0.44
65_V	91_V	0.721	0.43
137_K	256_D	0.720	0.43
52_E	277_R	0.718	0.43
3_I	11_I	0.718	0.43
172_N	175_N	0.716	0.43
137_K	257_Y	0.715	0.43
242_L	251_I	0.715	0.43
201_G	276_P	0.715	0.43
118_F	156_A	0.714	0.43
24_H	199_H	0.713	0.43
67_P	135_F	0.711	0.43
169_T	195_I	0.710	0.42
150_E	180_E	0.709	0.42
209_I	238_T	0.709	0.42
4_P	16_I	0.708	0.42
52_E	280_I	0.702	0.42
4_P	13_S	0.702	0.42
11_I	75_D	0.701	0.42
201_G	313_F	0.699	0.42
226_L	229_F	0.696	0.41
153_I	219_I	0.696	0.41
122_I	159_A	0.696	0.41
62_K	89_N	0.695	0.41
81_K	251_I	0.694	0.41
9_D	16_I	0.693	0.41
145_I	177_T	0.691	0.41
206_I	241_R	0.688	0.41
168_I	220_G	0.687	0.40
113_E	116_D	0.687	0.40
67_P	198_G	0.687	0.40
257_Y	276_P	0.687	0.40
27_V	258_C	0.686	0.40
23_E	225_G	0.686	0.40
240_L	243_I	0.684	0.40
69_V	97_Y	0.682	0.40
141_D	172_N	0.681	0.40
289_P	292_K	0.681	0.40
97_Y	226_L	0.680	0.40
55_R	264_G	0.676	0.40
112_D	116_D	0.675	0.39
15_D	304_I	0.675	0.39
46_F	78_F	0.673	0.39
169_T	213_A	0.671	0.39
6_V	9_D	0.671	0.39
255_H	283_I	0.669	0.39
243_I	300_V	0.668	0.39
11_I	15_D	0.664	0.39
87_G	90_L	0.663	0.38
257_Y	263_W	0.660	0.38
263_W	276_P	0.659	0.38
205_N	208_Y	0.659	0.38
45_E	49_A	0.659	0.38
143_P	177_T	0.658	0.38
119_I	123_K	0.658	0.38
102_L	114_I	0.657	0.38
102_L	172_N	0.656	0.38
135_F	169_T	0.656	0.38
22_H	199_H	0.656	0.38
18_F	302_A	0.654	0.38
292_K	301_I	0.654	0.38
196_L	220_G	0.653	0.38
93_G	135_F	0.653	0.38
140_A	200_L	0.648	0.37
190_V	194_K	0.648	0.37
7_G	131_N	0.646	0.37
68_T	128_G	0.646	0.37
171_S	197_I	0.645	0.37
28_F	103_P	0.643	0.37
187_E	194_K	0.642	0.37
16_I	123_K	0.640	0.37
111_I	154_R	0.639	0.36
226_L	259_C	0.638	0.36
141_D	153_I	0.636	0.36
153_I	169_T	0.634	0.36
154_R	184_I	0.634	0.36
71_G	97_Y	0.634	0.36
152_V	165_V	0.630	0.36
183_R	197_I	0.630	0.36
77_R	90_L	0.630	0.36
160_N	217_S	0.629	0.36
118_F	159_A	0.628	0.36
218_F	250_K	0.627	0.35
83_V	88_I	0.626	0.35
15_D	89_N	0.621	0.35
219_I	238_T	0.620	0.35
96_I	117_L	0.619	0.35
224_Y	282_L	0.618	0.35
61_V	283_I	0.615	0.34
4_P	34_Q	0.614	0.34
173_A	282_L	0.614	0.34
306_K	310_K	0.613	0.34
25_L	79_M	0.612	0.34
20_L	255_H	0.611	0.34
171_S	313_F	0.609	0.34
239_T	296_V	0.609	0.34
185_L	195_I	0.608	0.34
240_L	296_V	0.605	0.34
128_G	185_L	0.605	0.34
6_V	11_I	0.603	0.33
121_D	184_I	0.599	0.33
192_P	217_S	0.598	0.33
172_N	202_D	0.597	0.33
259_C	262_D	0.596	0.33
75_D	311_K	0.595	0.33
176_N	211_K	0.595	0.33
111_I	151_K	0.594	0.33
50_V	54_K	0.594	0.33
94_T	126_I	0.593	0.33
260_T	270_Y	0.593	0.33
224_Y	227_D	0.591	0.33
94_T	133_A	0.591	0.33
234_K	237_E	0.589	0.32
26_R	49_A	0.589	0.32
249_D	311_K	0.584	0.32
112_D	162_E	0.584	0.32
185_L	192_P	0.583	0.32
109_R	117_L	0.582	0.32
20_L	23_E	0.581	0.32
45_E	52_E	0.581	0.32
257_Y	313_F	0.578	0.32
225_G	254_S	0.578	0.32
76_I	127_Q	0.578	0.32
202_D	259_C	0.577	0.31
88_I	207_D	0.577	0.31
27_V	72_L	0.575	0.31
56_A	59_F	0.572	0.31
93_G	258_C	0.570	0.31
232_V	282_L	0.569	0.31
191_D	245_D	0.568	0.31
260_T	277_R	0.565	0.31
161_K	250_K	0.565	0.31
179_L	212_I	0.564	0.30
72_L	97_Y	0.564	0.30
140_A	145_I	0.560	0.30
14_K	237_E	0.560	0.30
194_K	292_K	0.559	0.30
249_D	293_R	0.559	0.30
237_E	298_E	0.559	0.30
4_P	91_V	0.557	0.30
168_I	196_L	0.556	0.30
239_T	284_F	0.555	0.30
195_I	198_G	0.554	0.30
221_L	287_T	0.553	0.30
136_V	159_A	0.551	0.29
20_L	56_A	0.549	0.29
93_G	152_V	0.548	0.29
8_K	133_A	0.547	0.29
137_K	170_H	0.547	0.29
73_G	205_N	0.546	0.29
150_E	158_I	0.546	0.29
116_D	147_K	0.541	0.29
252_M	290_F	0.541	0.29
221_L	251_I	0.538	0.29
11_I	62_K	0.538	0.29
213_A	217_S	0.536	0.28
84_K	130_L	0.534	0.28
64_I	280_I	0.533	0.28
115_A	159_A	0.532	0.28
121_D	166_P	0.531	0.28
8_K	87_G	0.530	0.28
251_I	303_T	0.525	0.28
70_M	117_L	0.522	0.27
224_Y	235_R	0.519	0.27
74_R	222_D	0.519	0.27
183_R	211_K	0.519	0.27
65_V	122_I	0.518	0.27
167_I	190_V	0.517	0.27
4_P	19_T	0.516	0.27
140_A	153_I	0.516	0.27
74_R	136_V	0.512	0.27
198_G	262_D	0.512	0.27
229_F	259_C	0.511	0.27
57_M	284_F	0.510	0.27
230_L	234_K	0.510	0.27
111_I	188_E	0.509	0.26
118_F	139_A	0.508	0.26
143_P	176_N	0.508	0.26
91_V	116_D	0.507	0.26
202_D	262_D	0.506	0.26
119_I	191_D	0.506	0.26
141_D	169_T	0.506	0.26
171_S	203_T	0.505	0.26
11_I	89_N	0.505	0.26
179_L	182_Q	0.505	0.26
35_Q	39_L	0.504	0.26
133_A	163_T	0.504	0.26
248_S	251_I	0.503	0.26
27_V	103_P	0.503	0.26
11_I	63_T	0.502	0.26
36_W	39_L	0.502	0.26
190_V	195_I	0.501	0.26
103_P	106_F	0.501	0.26
71_G	131_N	0.501	0.26
191_D	310_K	0.500	0.26

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3k2gA	3	0.9682	100	0.422	Contact Map
3rhgA	2	0.965	100	0.439	Contact Map
3pnzA	4	0.965	100	0.548	Contact Map
3gtxA	2	0.9936	100	0.571	Contact Map
4if2A	2	0.9904	100	0.573	Contact Map
3tn4A	2	0.9936	100	0.573	Contact Map
3ovgA	4	0.9745	100	0.583	Contact Map
2ob3A	2	0.9682	100	0.591	Contact Map
4kezA	2	1	100	0.604	Contact Map
1bf6A	1	0.9236	100	0.627	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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