Q97VT4 - SULSO - GREMLIN Contacts

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Q97VT4 - Glycerol-3-phosphate dehydrogenase chain A (GlpA)

UniProt:	Q97VT4	Sequences: MSTFLMLNPLHIIMEIKSTVTVIGGGVSGLFTALDLALRGIDVTLVDRGDIGYGTSGKFHGLLHSGARYAVTDPDSARECIQENKIISKIAPHTVKDTGGVFLGITDDDLQFSETFIKALNKVGIESKVIDVKEVLQKEPFINRDTKMAIWVPDKVVYGYDLLASVAITASLNGAKILTYNEVVEIIRENNNVKGVKVLDKINNNTNVIKSDIIVNTAGPWSFNIIKMAGLEEIPIMPTAGIIVVFDKRVNNMVINRLRPPSDGDIIVPYADSSILGTTATIIEDPDNFTISDEDIAMLVNEGAYLIPKLKNMRVVRSYASVRPLIKSEVSAREASRDFRIIDHEKENGLSGLVSVIGGKFTTGRLAGERVADLVSSKLGIKSASKTATTKLLSPNDINLLNYAEKIRLPKVIVRSILDRKGSLDEERYLSSLYILLSLISRGTM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	445 (348)
Sequences:	23422 (16748)
Seq/√Len:	897.8

ECOLI - GLPA GLPD PUUB LHGO MTOX MQO DADA
BACSU - GLPD YHFW YURR GLOX
HALSA - Q9HNS4 Q9HSD9
SULSO - Q97VT4 Q980U0 Q97ZD5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
170_A	175_A	4.666	1.00
18_S	44_T	4.070	1.00
48_R	182_E	3.413	1.00
21_T	196_V	3.222	1.00
185_E	197_K	3.029	1.00
19_T	212_D	2.781	1.00
19_T	42_D	2.692	1.00
21_T	211_S	2.665	1.00
187_I	197_K	2.635	1.00
44_T	178_L	2.619	1.00
131_D	134_E	2.555	1.00
197_K	208_V	2.495	1.00
195_G	208_V	2.471	1.00
187_I	195_G	2.443	1.00
182_E	205_N	2.321	1.00
135_V	149_A	2.320	1.00
46_V	209_I	2.318	1.00
42_D	176_K	2.284	1.00
20_V	36_L	2.259	1.00
37_A	173_N	2.245	1.00
41_I	376_S	2.207	1.00
134_E	137_Q	2.175	1.00
110_L	148_M	2.143	1.00
17_K	210_K	2.108	1.00
37_A	175_A	2.103	1.00
17_K	212_D	2.080	1.00
21_T	46_V	2.036	1.00
198_V	207_N	2.030	1.00
247_D	314_R	2.025	1.00
30_L	167_A	2.015	1.00
20_V	41_I	2.003	1.00
32_T	215_V	1.999	1.00
51_I	179_T	1.975	1.00
30_L	163_L	1.935	1.00
128_K	134_E	1.925	1.00
195_G	210_K	1.828	1.00
39_R	376_S	1.828	1.00
21_T	209_I	1.808	1.00
38_L	173_N	1.788	1.00
34_L	169_T	1.779	1.00
117_I	121_N	1.775	1.00
114_E	129_V	1.774	1.00
25_G	51_I	1.748	1.00
39_R	378_K	1.735	1.00
51_I	167_A	1.729	1.00
241_G	323_R	1.725	1.00
213_I	354_V	1.706	1.00
215_V	375_V	1.696	1.00
83_E	86_I	1.686	1.00
183_V	196_V	1.655	1.00
35_D	369_E	1.653	1.00
35_D	368_G	1.645	1.00
80_C	83_E	1.643	1.00
114_E	118_K	1.642	1.00
132_V	136_L	1.639	1.00
84_N	87_I	1.609	1.00
18_S	176_K	1.606	1.00
128_K	153_P	1.598	1.00
373_D	378_K	1.584	1.00
34_L	38_L	1.575	1.00
169_T	172_L	1.563	1.00
18_S	21_T	1.562	1.00
118_K	121_N	1.557	1.00
169_T	173_N	1.535	1.00
297_A	301_N	1.535	1.00
222_S	357_I	1.534	1.00
178_L	181_N	1.524	1.00
38_L	90_I	1.511	1.00
181_N	198_V	1.501	1.00
184_V	197_K	1.496	1.00
37_A	170_A	1.488	1.00
128_K	151_W	1.486	1.00
246_F	249_R	1.476	1.00
168_I	171_S	1.474	1.00
88_S	97_D	1.470	1.00
118_K	122_K	1.467	1.00
189_E	195_G	1.456	1.00
216_N	222_S	1.453	1.00
83_E	90_I	1.446	1.00
356_V	371_V	1.443	1.00
247_D	316_V	1.442	1.00
198_V	209_I	1.440	1.00
356_V	367_A	1.436	1.00
44_T	209_I	1.427	1.00
198_V	205_N	1.423	1.00
35_D	39_R	1.402	1.00
167_A	177_I	1.398	1.00
168_I	172_L	1.389	1.00
82_Q	86_I	1.388	1.00
354_V	375_V	1.386	1.00
158_Y	161_D	1.380	1.00
354_V	371_V	1.371	1.00
50_D	179_T	1.352	1.00
107_D	147_K	1.349	1.00
213_I	375_V	1.347	1.00
262_S	265_D	1.345	1.00
31_F	35_D	1.340	1.00
187_I	208_V	1.339	1.00
178_L	207_N	1.336	1.00
133_K	137_Q	1.335	1.00
39_R	372_A	1.334	1.00
111_Q	114_E	1.333	1.00
20_V	213_I	1.331	1.00
39_R	373_D	1.327	1.00
130_I	134_E	1.323	1.00
79_E	369_E	1.318	1.00
91_A	94_T	1.312	1.00
21_T	44_T	1.308	1.00
79_E	83_E	1.296	1.00
49_G	53_Y	1.287	1.00
373_D	381_I	1.286	1.00
369_E	373_D	1.279	1.00
27_V	364_G	1.269	1.00
25_G	45_L	1.268	1.00
99_G	151_W	1.265	1.00
85_K	97_D	1.262	1.00
186_I	214_I	1.261	1.00
189_E	210_K	1.256	1.00
46_V	198_V	1.254	1.00
76_S	80_C	1.248	1.00
134_E	138_K	1.246	1.00
211_S	214_I	1.244	1.00
79_E	82_Q	1.243	1.00
167_A	171_S	1.243	1.00
28_S	356_V	1.241	1.00
138_K	151_W	1.241	1.00
89_K	93_H	1.241	1.00
80_C	84_N	1.240	1.00
188_R	350_L	1.234	1.00
79_E	84_N	1.232	1.00
198_V	206_T	1.231	1.00
36_L	372_A	1.224	1.00
293_D	297_A	1.222	1.00
110_L	114_E	1.212	1.00
104_G	113_S	1.211	1.00
84_N	88_S	1.208	1.00
49_G	54_G	1.207	1.00
86_I	89_K	1.203	1.00
115_T	118_K	1.199	1.00
23_I	218_A	1.197	1.00
46_V	183_V	1.196	1.00
33_A	43_V	1.196	1.00
30_L	45_L	1.189	1.00
18_S	42_D	1.186	1.00
86_I	90_I	1.179	1.00
300_V	304_A	1.175	1.00
107_D	111_Q	1.169	1.00
95_V	155_K	1.168	1.00
19_T	41_I	1.165	1.00
185_E	228_M	1.161	1.00
35_D	38_L	1.160	1.00
52_G	163_L	1.142	1.00
368_G	372_A	1.136	1.00
46_V	178_L	1.133	1.00
38_L	93_H	1.131	1.00
22_V	33_A	1.126	1.00
45_L	177_I	1.124	1.00
130_I	138_K	1.111	1.00
188_R	194_K	1.110	1.00
216_N	353_L	1.109	1.00
46_V	211_S	1.106	1.00
111_Q	115_T	1.102	1.00
110_L	129_V	1.092	1.00
224_N	227_K	1.089	1.00
34_L	173_N	1.088	1.00
78_R	82_Q	1.084	1.00
184_V	205_N	1.077	1.00
99_G	153_P	1.077	1.00
30_L	170_A	1.077	1.00
117_I	150_I	1.071	1.00
106_T	109_D	1.069	1.00
225_I	228_M	1.067	1.00
126_E	153_P	1.066	1.00
341_I	367_A	1.063	1.00
218_A	225_I	1.052	1.00
354_V	374_L	1.037	1.00
85_K	89_K	1.030	1.00
31_F	166_V	1.021	1.00
19_T	44_T	1.021	1.00
32_T	356_V	1.019	1.00
76_S	84_N	1.017	1.00
87_I	91_A	1.014	1.00
23_I	214_I	1.013	1.00
31_F	368_G	1.009	1.00
157_V	162_L	0.999	1.00
136_L	144_R	0.999	1.00
117_I	129_V	0.996	1.00
87_I	94_T	0.996	1.00
36_L	41_I	0.994	1.00
51_I	177_I	0.993	1.00
90_I	93_H	0.989	1.00
292_S	295_D	0.986	1.00
86_I	369_E	0.986	1.00
25_G	47_D	0.981	1.00
160_Y	164_A	0.980	1.00
128_K	138_K	0.978	1.00
32_T	368_G	0.974	1.00
330_V	339_F	0.970	1.00
216_N	355_S	0.970	1.00
192_N	212_D	0.969	1.00
181_N	207_N	0.969	1.00
22_V	32_T	0.966	1.00
101_V	135_V	0.964	1.00
33_A	45_L	0.964	1.00
76_S	79_E	0.960	1.00
83_E	87_I	0.959	1.00
370_R	373_D	0.958	1.00
33_A	175_A	0.957	1.00
82_Q	369_E	0.956	1.00
186_I	196_V	0.952	1.00
33_A	170_A	0.949	1.00
77_A	80_C	0.947	1.00
301_N	304_A	0.944	1.00
302_E	305_Y	0.944	1.00
44_T	176_K	0.941	1.00
83_E	94_T	0.941	1.00
256_N	259_R	0.932	1.00
216_N	226_I	0.928	1.00
32_T	217_T	0.927	1.00
17_K	42_D	0.925	1.00
88_S	91_A	0.925	1.00
192_N	195_G	0.924	1.00
218_A	222_S	0.922	1.00
30_L	177_I	0.921	1.00
110_L	147_K	0.919	1.00
178_L	209_I	0.912	1.00
84_N	90_I	0.909	1.00
181_N	209_I	0.904	1.00
186_I	193_V	0.903	1.00
165_S	169_T	0.903	1.00
90_I	94_T	0.902	1.00
82_Q	85_K	0.902	1.00
296_I	318_S	0.899	1.00
133_K	136_L	0.890	1.00
41_I	213_I	0.890	1.00
50_D	53_Y	0.886	1.00
347_E	355_S	0.886	1.00
157_V	361_F	0.884	1.00
161_D	164_A	0.884	1.00
350_L	353_L	0.880	1.00
81_I	85_K	0.878	1.00
372_A	375_V	0.878	1.00
246_F	276_L	0.870	1.00
43_V	175_A	0.867	1.00
255_I	258_L	0.866	1.00
192_N	210_K	0.864	1.00
193_V	214_I	0.862	1.00
162_L	365_R	0.862	1.00
130_I	135_V	0.860	1.00
162_L	361_F	0.859	1.00
23_I	183_V	0.855	1.00
45_L	167_A	0.854	1.00
47_D	50_D	0.848	1.00
188_R	193_V	0.847	1.00
50_D	180_Y	0.847	1.00
217_T	356_V	0.843	1.00
80_C	87_I	0.838	1.00
121_N	127_S	0.837	1.00
58_K	319_Y	0.836	1.00
183_V	186_I	0.835	1.00
184_V	206_T	0.835	1.00
27_V	163_L	0.835	1.00
64_H	359_G	0.833	1.00
45_L	175_A	0.832	1.00
170_A	177_I	0.826	1.00
132_V	135_V	0.825	1.00
31_F	364_G	0.818	1.00
188_R	192_N	0.818	1.00
189_E	194_K	0.816	1.00
269_P	272_D	0.811	1.00
170_A	174_G	0.810	1.00
83_E	88_S	0.810	1.00
252_N	255_I	0.810	1.00
276_L	303_G	0.807	1.00
77_A	84_N	0.804	1.00
129_V	148_M	0.803	1.00
81_I	84_N	0.802	1.00
85_K	88_S	0.799	1.00
18_S	212_D	0.797	1.00
77_A	83_E	0.791	1.00
76_S	83_E	0.789	1.00
77_A	81_I	0.789	1.00
58_K	321_S	0.788	1.00
116_F	120_L	0.784	1.00
16_I	178_L	0.783	1.00
27_V	56_S	0.783	1.00
162_L	166_V	0.781	1.00
61_G	159_G	0.781	1.00
34_L	166_V	0.780	1.00
39_R	369_E	0.780	1.00
101_V	149_A	0.777	1.00
304_A	311_K	0.777	1.00
213_I	216_N	0.776	1.00
55_T	220_P	0.776	1.00
257_R	260_P	0.775	1.00
253_M	256_N	0.774	1.00
165_S	168_I	0.772	1.00
87_I	90_I	0.767	1.00
83_E	91_A	0.766	1.00
88_S	94_T	0.762	1.00
187_I	194_K	0.759	1.00
171_S	177_I	0.755	1.00
186_I	229_A	0.753	1.00
64_H	362_T	0.753	1.00
251_N	255_I	0.753	1.00
227_K	232_E	0.750	1.00
76_S	87_I	0.749	1.00
79_E	366_L	0.746	1.00
135_V	146_T	0.740	1.00
36_L	375_V	0.740	1.00
183_V	225_I	0.739	1.00
250_V	253_M	0.736	1.00
80_C	90_I	0.735	1.00
189_E	192_N	0.734	1.00
240_A	281_T	0.734	1.00
39_R	377_S	0.733	1.00
21_T	214_I	0.732	1.00
181_N	206_T	0.731	1.00
298_M	301_N	0.730	1.00
213_I	352_G	0.728	1.00
273_S	316_V	0.728	1.00
245_V	275_I	0.727	1.00
197_K	206_T	0.726	1.00
23_I	216_N	0.724	1.00
296_I	300_V	0.724	1.00
16_I	44_T	0.718	1.00
359_G	362_T	0.717	1.00
32_T	371_V	0.716	1.00
182_E	224_N	0.715	1.00
101_V	130_I	0.713	1.00
301_N	305_Y	0.713	1.00
244_V	315_V	0.711	1.00
27_V	361_F	0.709	1.00
80_C	91_A	0.709	1.00
96_K	156_V	0.706	1.00
304_A	312_N	0.703	1.00
171_S	176_K	0.701	1.00
236_I	324_P	0.696	1.00
214_I	352_G	0.696	1.00
135_V	138_K	0.694	1.00
188_R	351_S	0.693	1.00
242_I	281_T	0.692	1.00
245_V	317_R	0.692	1.00
37_A	42_D	0.692	1.00
341_I	371_V	0.688	1.00
47_D	179_T	0.687	1.00
79_E	90_I	0.686	1.00
42_D	212_D	0.685	1.00
212_D	352_G	0.678	1.00
68_R	71_V	0.677	1.00
89_K	92_P	0.677	1.00
192_N	351_S	0.676	1.00
20_V	215_V	0.674	1.00
136_L	143_N	0.673	1.00
239_T	325_L	0.672	1.00
79_E	94_T	0.672	1.00
260_P	263_D	0.671	1.00
227_K	230_G	0.670	1.00
31_F	365_R	0.670	1.00
121_N	126_E	0.670	1.00
366_L	369_E	0.666	1.00
83_E	93_H	0.663	1.00
184_V	207_N	0.662	1.00
88_S	92_P	0.662	1.00
297_A	300_V	0.656	1.00
247_D	273_S	0.655	1.00
373_D	380_G	0.652	1.00
84_N	91_A	0.652	1.00
195_G	214_I	0.651	1.00
226_I	355_S	0.649	1.00
254_V	258_L	0.646	1.00
266_I	277_G	0.644	1.00
35_D	372_A	0.643	1.00
117_I	127_S	0.642	1.00
129_V	150_I	0.641	1.00
130_I	151_W	0.641	1.00
221_W	224_N	0.640	1.00
120_L	127_S	0.638	1.00
348_N	351_S	0.635	1.00
326_I	358_G	0.632	1.00
60_H	266_I	0.629	1.00
311_K	314_R	0.627	1.00
100_G	154_D	0.627	1.00
88_S	93_H	0.626	1.00
104_G	110_L	0.626	1.00
339_F	342_I	0.626	1.00
19_T	210_K	0.625	1.00
56_S	163_L	0.625	1.00
215_V	371_V	0.625	1.00
101_V	151_W	0.623	1.00
79_E	87_I	0.622	1.00
261_P	264_G	0.620	1.00
119_A	122_K	0.620	1.00
326_I	340_R	0.620	1.00
63_L	157_V	0.618	1.00
32_T	375_V	0.614	1.00
328_S	342_I	0.613	1.00
28_S	367_A	0.613	1.00
256_N	260_P	0.610	1.00
186_I	228_M	0.609	1.00
86_I	94_T	0.609	1.00
294_E	297_A	0.609	1.00
79_E	86_I	0.608	1.00
304_A	310_L	0.607	1.00
63_L	362_T	0.603	1.00
366_L	370_R	0.603	1.00
261_P	265_D	0.603	1.00
293_D	296_I	0.603	1.00
186_I	194_K	0.600	1.00
240_A	320_A	0.599	1.00
116_F	121_N	0.598	1.00
300_V	312_N	0.597	1.00
365_R	368_G	0.597	1.00
310_L	313_M	0.596	1.00
186_I	216_N	0.592	1.00
37_A	43_V	0.591	1.00
78_R	81_I	0.591	1.00
63_L	95_V	0.589	1.00
161_D	165_S	0.588	1.00
86_I	91_A	0.587	1.00
16_I	42_D	0.586	1.00
80_C	86_I	0.584	1.00
237_M	282_I	0.583	1.00
347_E	350_L	0.583	1.00
347_E	353_L	0.581	1.00
77_A	87_I	0.581	1.00
255_I	259_R	0.580	1.00
16_I	176_K	0.580	1.00
141_F	309_K	0.579	1.00
251_N	254_V	0.578	1.00
25_G	179_T	0.577	1.00
70_A	75_D	0.577	1.00
226_I	229_A	0.576	1.00
260_P	265_D	0.574	1.00
46_V	181_N	0.570	1.00
292_S	296_I	0.570	1.00
166_V	364_G	0.570	1.00
84_N	94_T	0.569	1.00
131_D	137_Q	0.568	1.00
241_G	279_T	0.568	1.00
48_R	54_G	0.568	1.00
195_G	198_V	0.566	1.00
184_V	198_V	0.564	1.00
84_N	162_L	0.564	1.00
372_A	376_S	0.563	1.00
250_V	255_I	0.562	1.00
170_A	173_N	0.561	1.00
20_V	43_V	0.561	1.00
113_S	117_I	0.557	1.00
349_G	355_S	0.556	1.00
104_G	109_D	0.554	1.00
48_R	221_W	0.554	1.00
167_A	179_T	0.554	1.00
66_G	69_Y	0.552	1.00
163_L	167_A	0.552	1.00
112_F	115_T	0.552	1.00
188_R	195_G	0.551	1.00
108_D	111_Q	0.550	1.00
136_L	145_D	0.550	1.00
298_M	302_E	0.550	1.00
229_A	353_L	0.550	1.00
300_V	318_S	0.547	1.00
351_S	354_V	0.546	1.00
52_G	160_Y	0.546	1.00
139_E	255_I	0.545	1.00
364_G	368_G	0.545	1.00
245_V	273_S	0.544	1.00
135_V	142_I	0.541	1.00
254_V	257_R	0.541	1.00
196_V	214_I	0.541	1.00
186_I	353_L	0.539	1.00
22_V	43_V	0.539	1.00
38_L	169_T	0.539	1.00
94_T	169_T	0.539	1.00
62_L	266_I	0.537	1.00
116_F	119_A	0.537	1.00
114_E	148_M	0.536	1.00
50_D	164_A	0.535	1.00
107_D	110_L	0.533	1.00
80_C	93_H	0.533	1.00
374_L	377_S	0.532	1.00
80_C	94_T	0.531	1.00
59_F	361_F	0.530	1.00
60_H	243_I	0.530	1.00
279_T	323_R	0.528	1.00
114_E	117_I	0.527	1.00
34_L	170_A	0.527	1.00
370_R	374_L	0.527	1.00
302_E	306_L	0.525	1.00
188_R	352_G	0.525	1.00
191_N	351_S	0.525	1.00
28_S	217_T	0.525	1.00
79_E	370_R	0.523	1.00
115_T	119_A	0.521	1.00
235_P	327_K	0.521	1.00
189_E	193_V	0.520	1.00
339_F	363_T	0.517	1.00
187_I	210_K	0.517	1.00
127_S	152_V	0.517	1.00
279_T	282_I	0.516	1.00
236_I	357_I	0.516	1.00
222_S	236_I	0.514	1.00
355_S	358_G	0.513	1.00
250_V	254_V	0.513	1.00
76_S	94_T	0.512	1.00
55_T	323_R	0.512	1.00
76_S	90_I	0.511	1.00
131_D	135_V	0.511	1.00
56_S	59_F	0.510	1.00
84_N	92_P	0.509	1.00
31_F	162_L	0.508	1.00
105_I	109_D	0.508	1.00
41_I	375_V	0.507	1.00
105_I	305_Y	0.505	1.00
246_F	315_V	0.505	1.00
350_L	355_S	0.504	1.00
184_V	187_I	0.504	1.00
379_L	382_K	0.504	1.00
190_N	193_V	0.504	1.00
242_I	292_S	0.503	1.00
352_G	358_G	0.501	1.00
85_K	94_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2rghA	2	0.9663	100	0.324	Contact Map
3da1A	1	0.8899	100	0.341	Contact Map
2qcuA	2	0.9506	100	0.362	Contact Map
4h1bA	1	0.8157	100	0.419	Contact Map
4x9mA	1	0.8135	100	0.445	Contact Map
1pj5A	3	0.9169	100	0.457	Contact Map
3axbA	2	0.827	100	0.459	Contact Map
1ryiA	4	0.7865	100	0.459	Contact Map
1y56B	1	0.8202	100	0.46	Contact Map
2gagB	1	0.8674	100	0.47	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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