GREMLIN Database
Q97VT4 - Glycerol-3-phosphate dehydrogenase chain A (GlpA)
UniProt: Q97VT4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (348)
Sequences: 23422 (16748)
Seq/√Len: 897.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_A175_A4.6661.00
18_S44_T4.0701.00
48_R182_E3.4131.00
21_T196_V3.2221.00
185_E197_K3.0291.00
19_T212_D2.7811.00
19_T42_D2.6921.00
21_T211_S2.6651.00
187_I197_K2.6351.00
44_T178_L2.6191.00
131_D134_E2.5551.00
197_K208_V2.4951.00
195_G208_V2.4711.00
187_I195_G2.4431.00
182_E205_N2.3211.00
135_V149_A2.3201.00
46_V209_I2.3181.00
42_D176_K2.2841.00
20_V36_L2.2591.00
37_A173_N2.2451.00
41_I376_S2.2071.00
134_E137_Q2.1751.00
110_L148_M2.1431.00
17_K210_K2.1081.00
37_A175_A2.1031.00
17_K212_D2.0801.00
21_T46_V2.0361.00
198_V207_N2.0301.00
247_D314_R2.0251.00
30_L167_A2.0151.00
20_V41_I2.0031.00
32_T215_V1.9991.00
51_I179_T1.9751.00
30_L163_L1.9351.00
128_K134_E1.9251.00
195_G210_K1.8281.00
39_R376_S1.8281.00
21_T209_I1.8081.00
38_L173_N1.7881.00
34_L169_T1.7791.00
117_I121_N1.7751.00
114_E129_V1.7741.00
25_G51_I1.7481.00
39_R378_K1.7351.00
51_I167_A1.7291.00
241_G323_R1.7251.00
213_I354_V1.7061.00
215_V375_V1.6961.00
83_E86_I1.6861.00
183_V196_V1.6551.00
35_D369_E1.6531.00
35_D368_G1.6451.00
80_C83_E1.6431.00
114_E118_K1.6421.00
132_V136_L1.6391.00
84_N87_I1.6091.00
18_S176_K1.6061.00
128_K153_P1.5981.00
373_D378_K1.5841.00
34_L38_L1.5751.00
169_T172_L1.5631.00
18_S21_T1.5621.00
118_K121_N1.5571.00
169_T173_N1.5351.00
297_A301_N1.5351.00
222_S357_I1.5341.00
178_L181_N1.5241.00
38_L90_I1.5111.00
181_N198_V1.5011.00
184_V197_K1.4961.00
37_A170_A1.4881.00
128_K151_W1.4861.00
246_F249_R1.4761.00
168_I171_S1.4741.00
88_S97_D1.4701.00
118_K122_K1.4671.00
189_E195_G1.4561.00
216_N222_S1.4531.00
83_E90_I1.4461.00
356_V371_V1.4431.00
247_D316_V1.4421.00
198_V209_I1.4401.00
356_V367_A1.4361.00
44_T209_I1.4271.00
198_V205_N1.4231.00
35_D39_R1.4021.00
167_A177_I1.3981.00
168_I172_L1.3891.00
82_Q86_I1.3881.00
354_V375_V1.3861.00
158_Y161_D1.3801.00
354_V371_V1.3711.00
50_D179_T1.3521.00
107_D147_K1.3491.00
213_I375_V1.3471.00
262_S265_D1.3451.00
31_F35_D1.3401.00
187_I208_V1.3391.00
178_L207_N1.3361.00
133_K137_Q1.3351.00
39_R372_A1.3341.00
111_Q114_E1.3331.00
20_V213_I1.3311.00
39_R373_D1.3271.00
130_I134_E1.3231.00
79_E369_E1.3181.00
91_A94_T1.3121.00
21_T44_T1.3081.00
79_E83_E1.2961.00
49_G53_Y1.2871.00
373_D381_I1.2861.00
369_E373_D1.2791.00
27_V364_G1.2691.00
25_G45_L1.2681.00
99_G151_W1.2651.00
85_K97_D1.2621.00
186_I214_I1.2611.00
189_E210_K1.2561.00
46_V198_V1.2541.00
76_S80_C1.2481.00
134_E138_K1.2461.00
211_S214_I1.2441.00
79_E82_Q1.2431.00
167_A171_S1.2431.00
28_S356_V1.2411.00
138_K151_W1.2411.00
89_K93_H1.2411.00
80_C84_N1.2401.00
188_R350_L1.2341.00
79_E84_N1.2321.00
198_V206_T1.2311.00
36_L372_A1.2241.00
293_D297_A1.2221.00
110_L114_E1.2121.00
104_G113_S1.2111.00
84_N88_S1.2081.00
49_G54_G1.2071.00
86_I89_K1.2031.00
115_T118_K1.1991.00
23_I218_A1.1971.00
46_V183_V1.1961.00
33_A43_V1.1961.00
30_L45_L1.1891.00
18_S42_D1.1861.00
86_I90_I1.1791.00
300_V304_A1.1751.00
107_D111_Q1.1691.00
95_V155_K1.1681.00
19_T41_I1.1651.00
185_E228_M1.1611.00
35_D38_L1.1601.00
52_G163_L1.1421.00
368_G372_A1.1361.00
46_V178_L1.1331.00
38_L93_H1.1311.00
22_V33_A1.1261.00
45_L177_I1.1241.00
130_I138_K1.1111.00
188_R194_K1.1101.00
216_N353_L1.1091.00
46_V211_S1.1061.00
111_Q115_T1.1021.00
110_L129_V1.0921.00
224_N227_K1.0891.00
34_L173_N1.0881.00
78_R82_Q1.0841.00
184_V205_N1.0771.00
99_G153_P1.0771.00
30_L170_A1.0771.00
117_I150_I1.0711.00
106_T109_D1.0691.00
225_I228_M1.0671.00
126_E153_P1.0661.00
341_I367_A1.0631.00
218_A225_I1.0521.00
354_V374_L1.0371.00
85_K89_K1.0301.00
31_F166_V1.0211.00
19_T44_T1.0211.00
32_T356_V1.0191.00
76_S84_N1.0171.00
87_I91_A1.0141.00
23_I214_I1.0131.00
31_F368_G1.0091.00
157_V162_L0.9991.00
136_L144_R0.9991.00
117_I129_V0.9961.00
87_I94_T0.9961.00
36_L41_I0.9941.00
51_I177_I0.9931.00
90_I93_H0.9891.00
292_S295_D0.9861.00
86_I369_E0.9861.00
25_G47_D0.9811.00
160_Y164_A0.9801.00
128_K138_K0.9781.00
32_T368_G0.9741.00
330_V339_F0.9701.00
216_N355_S0.9701.00
192_N212_D0.9691.00
181_N207_N0.9691.00
22_V32_T0.9661.00
101_V135_V0.9641.00
33_A45_L0.9641.00
76_S79_E0.9601.00
83_E87_I0.9591.00
370_R373_D0.9581.00
33_A175_A0.9571.00
82_Q369_E0.9561.00
186_I196_V0.9521.00
33_A170_A0.9491.00
77_A80_C0.9471.00
301_N304_A0.9441.00
302_E305_Y0.9441.00
44_T176_K0.9411.00
83_E94_T0.9411.00
256_N259_R0.9321.00
216_N226_I0.9281.00
32_T217_T0.9271.00
17_K42_D0.9251.00
88_S91_A0.9251.00
192_N195_G0.9241.00
218_A222_S0.9221.00
30_L177_I0.9211.00
110_L147_K0.9191.00
178_L209_I0.9121.00
84_N90_I0.9091.00
181_N209_I0.9041.00
186_I193_V0.9031.00
165_S169_T0.9031.00
90_I94_T0.9021.00
82_Q85_K0.9021.00
296_I318_S0.8991.00
133_K136_L0.8901.00
41_I213_I0.8901.00
50_D53_Y0.8861.00
347_E355_S0.8861.00
157_V361_F0.8841.00
161_D164_A0.8841.00
350_L353_L0.8801.00
81_I85_K0.8781.00
372_A375_V0.8781.00
246_F276_L0.8701.00
43_V175_A0.8671.00
255_I258_L0.8661.00
192_N210_K0.8641.00
193_V214_I0.8621.00
162_L365_R0.8621.00
130_I135_V0.8601.00
162_L361_F0.8591.00
23_I183_V0.8551.00
45_L167_A0.8541.00
47_D50_D0.8481.00
188_R193_V0.8471.00
50_D180_Y0.8471.00
217_T356_V0.8431.00
80_C87_I0.8381.00
121_N127_S0.8371.00
58_K319_Y0.8361.00
183_V186_I0.8351.00
184_V206_T0.8351.00
27_V163_L0.8351.00
64_H359_G0.8331.00
45_L175_A0.8321.00
170_A177_I0.8261.00
132_V135_V0.8251.00
31_F364_G0.8181.00
188_R192_N0.8181.00
189_E194_K0.8161.00
269_P272_D0.8111.00
170_A174_G0.8101.00
83_E88_S0.8101.00
252_N255_I0.8101.00
276_L303_G0.8071.00
77_A84_N0.8041.00
129_V148_M0.8031.00
81_I84_N0.8021.00
85_K88_S0.7991.00
18_S212_D0.7971.00
77_A83_E0.7911.00
76_S83_E0.7891.00
77_A81_I0.7891.00
58_K321_S0.7881.00
116_F120_L0.7841.00
16_I178_L0.7831.00
27_V56_S0.7831.00
162_L166_V0.7811.00
61_G159_G0.7811.00
34_L166_V0.7801.00
39_R369_E0.7801.00
101_V149_A0.7771.00
304_A311_K0.7771.00
213_I216_N0.7761.00
55_T220_P0.7761.00
257_R260_P0.7751.00
253_M256_N0.7741.00
165_S168_I0.7721.00
87_I90_I0.7671.00
83_E91_A0.7661.00
88_S94_T0.7621.00
187_I194_K0.7591.00
171_S177_I0.7551.00
186_I229_A0.7531.00
64_H362_T0.7531.00
251_N255_I0.7531.00
227_K232_E0.7501.00
76_S87_I0.7491.00
79_E366_L0.7461.00
135_V146_T0.7401.00
36_L375_V0.7401.00
183_V225_I0.7391.00
250_V253_M0.7361.00
80_C90_I0.7351.00
189_E192_N0.7341.00
240_A281_T0.7341.00
39_R377_S0.7331.00
21_T214_I0.7321.00
181_N206_T0.7311.00
298_M301_N0.7301.00
213_I352_G0.7281.00
273_S316_V0.7281.00
245_V275_I0.7271.00
197_K206_T0.7261.00
23_I216_N0.7241.00
296_I300_V0.7241.00
16_I44_T0.7181.00
359_G362_T0.7171.00
32_T371_V0.7161.00
182_E224_N0.7151.00
101_V130_I0.7131.00
301_N305_Y0.7131.00
244_V315_V0.7111.00
27_V361_F0.7091.00
80_C91_A0.7091.00
96_K156_V0.7061.00
304_A312_N0.7031.00
171_S176_K0.7011.00
236_I324_P0.6961.00
214_I352_G0.6961.00
135_V138_K0.6941.00
188_R351_S0.6931.00
242_I281_T0.6921.00
245_V317_R0.6921.00
37_A42_D0.6921.00
341_I371_V0.6881.00
47_D179_T0.6871.00
79_E90_I0.6861.00
42_D212_D0.6851.00
212_D352_G0.6781.00
68_R71_V0.6771.00
89_K92_P0.6771.00
192_N351_S0.6761.00
20_V215_V0.6741.00
136_L143_N0.6731.00
239_T325_L0.6721.00
79_E94_T0.6721.00
260_P263_D0.6711.00
227_K230_G0.6701.00
31_F365_R0.6701.00
121_N126_E0.6701.00
366_L369_E0.6661.00
83_E93_H0.6631.00
184_V207_N0.6621.00
88_S92_P0.6621.00
297_A300_V0.6561.00
247_D273_S0.6551.00
373_D380_G0.6521.00
84_N91_A0.6521.00
195_G214_I0.6511.00
226_I355_S0.6491.00
254_V258_L0.6461.00
266_I277_G0.6441.00
35_D372_A0.6431.00
117_I127_S0.6421.00
129_V150_I0.6411.00
130_I151_W0.6411.00
221_W224_N0.6401.00
120_L127_S0.6381.00
348_N351_S0.6351.00
326_I358_G0.6321.00
60_H266_I0.6291.00
311_K314_R0.6271.00
100_G154_D0.6271.00
88_S93_H0.6261.00
104_G110_L0.6261.00
339_F342_I0.6261.00
19_T210_K0.6251.00
56_S163_L0.6251.00
215_V371_V0.6251.00
101_V151_W0.6231.00
79_E87_I0.6221.00
261_P264_G0.6201.00
119_A122_K0.6201.00
326_I340_R0.6201.00
63_L157_V0.6181.00
32_T375_V0.6141.00
328_S342_I0.6131.00
28_S367_A0.6131.00
256_N260_P0.6101.00
186_I228_M0.6091.00
86_I94_T0.6091.00
294_E297_A0.6091.00
79_E86_I0.6081.00
304_A310_L0.6071.00
63_L362_T0.6031.00
366_L370_R0.6031.00
261_P265_D0.6031.00
293_D296_I0.6031.00
186_I194_K0.6001.00
240_A320_A0.5991.00
116_F121_N0.5981.00
300_V312_N0.5971.00
365_R368_G0.5971.00
310_L313_M0.5961.00
186_I216_N0.5921.00
37_A43_V0.5911.00
78_R81_I0.5911.00
63_L95_V0.5891.00
161_D165_S0.5881.00
86_I91_A0.5871.00
16_I42_D0.5861.00
80_C86_I0.5841.00
237_M282_I0.5831.00
347_E350_L0.5831.00
347_E353_L0.5811.00
77_A87_I0.5811.00
255_I259_R0.5801.00
16_I176_K0.5801.00
141_F309_K0.5791.00
251_N254_V0.5781.00
25_G179_T0.5771.00
70_A75_D0.5771.00
226_I229_A0.5761.00
260_P265_D0.5741.00
46_V181_N0.5701.00
292_S296_I0.5701.00
166_V364_G0.5701.00
84_N94_T0.5691.00
131_D137_Q0.5681.00
241_G279_T0.5681.00
48_R54_G0.5681.00
195_G198_V0.5661.00
184_V198_V0.5641.00
84_N162_L0.5641.00
372_A376_S0.5631.00
250_V255_I0.5621.00
170_A173_N0.5611.00
20_V43_V0.5611.00
113_S117_I0.5571.00
349_G355_S0.5561.00
104_G109_D0.5541.00
48_R221_W0.5541.00
167_A179_T0.5541.00
66_G69_Y0.5521.00
163_L167_A0.5521.00
112_F115_T0.5521.00
188_R195_G0.5511.00
108_D111_Q0.5501.00
136_L145_D0.5501.00
298_M302_E0.5501.00
229_A353_L0.5501.00
300_V318_S0.5471.00
351_S354_V0.5461.00
52_G160_Y0.5461.00
139_E255_I0.5451.00
364_G368_G0.5451.00
245_V273_S0.5441.00
135_V142_I0.5411.00
254_V257_R0.5411.00
196_V214_I0.5411.00
186_I353_L0.5391.00
22_V43_V0.5391.00
38_L169_T0.5391.00
94_T169_T0.5391.00
62_L266_I0.5371.00
116_F119_A0.5371.00
114_E148_M0.5361.00
50_D164_A0.5351.00
107_D110_L0.5331.00
80_C93_H0.5331.00
374_L377_S0.5321.00
80_C94_T0.5311.00
59_F361_F0.5301.00
60_H243_I0.5301.00
279_T323_R0.5281.00
114_E117_I0.5271.00
34_L170_A0.5271.00
370_R374_L0.5271.00
302_E306_L0.5251.00
188_R352_G0.5251.00
191_N351_S0.5251.00
28_S217_T0.5251.00
79_E370_R0.5231.00
115_T119_A0.5211.00
235_P327_K0.5211.00
189_E193_V0.5201.00
339_F363_T0.5171.00
187_I210_K0.5171.00
127_S152_V0.5171.00
279_T282_I0.5161.00
236_I357_I0.5161.00
222_S236_I0.5141.00
355_S358_G0.5131.00
250_V254_V0.5131.00
76_S94_T0.5121.00
55_T323_R0.5121.00
76_S90_I0.5111.00
131_D135_V0.5111.00
56_S59_F0.5101.00
84_N92_P0.5091.00
31_F162_L0.5081.00
105_I109_D0.5081.00
41_I375_V0.5071.00
105_I305_Y0.5051.00
246_F315_V0.5051.00
350_L355_S0.5041.00
184_V187_I0.5041.00
379_L382_K0.5041.00
190_N193_V0.5041.00
242_I292_S0.5031.00
352_G358_G0.5011.00
85_K94_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rghA 2 0.9663 100 0.324 Contact Map
3da1A 1 0.8899 100 0.341 Contact Map
2qcuA 2 0.9506 100 0.362 Contact Map
4h1bA 1 0.8157 100 0.419 Contact Map
4x9mA 1 0.8135 100 0.445 Contact Map
1pj5A 3 0.9169 100 0.457 Contact Map
3axbA 2 0.827 100 0.459 Contact Map
1ryiA 4 0.7865 100 0.459 Contact Map
1y56B 1 0.8202 100 0.46 Contact Map
2gagB 1 0.8674 100 0.47 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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