GREMLIN Database
Q97VS8 - Uncharacterized protein
UniProt: Q97VS8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 137 (129)
Sequences: 2783 (1805)
Seq/√Len: 158.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
6_D31_K3.5051.00
25_V116_I3.0161.00
7_D129_H2.7131.00
49_A121_L2.6281.00
104_R109_V2.5961.00
39_C132_V2.5371.00
61_E78_K2.3531.00
65_T78_K2.3371.00
24_Q27_Q2.1871.00
8_I132_V2.1791.00
43_V48_A2.1411.00
34_I134_I2.1351.00
51_V93_T2.1211.00
44_A129_H2.0751.00
41_I132_V2.0401.00
73_P87_H1.9561.00
28_I132_V1.9541.00
26_E107_K1.8571.00
13_A17_E1.7641.00
58_G78_K1.7431.00
35_K105_E1.7191.00
40_L100_V1.6761.00
36_N104_R1.5541.00
58_G81_L1.5501.00
55_H115_N1.5461.00
66_K90_L1.5421.00
20_D115_N1.5381.00
67_I95_L1.5371.00
38_I100_V1.5071.00
9_Y129_H1.4551.00
5_F104_R1.4111.00
27_Q31_K1.4011.00
66_K70_F1.3391.00
92_A97_A1.2831.00
18_L119_V1.2591.00
40_L133_E1.2511.00
7_D44_A1.2481.00
49_A95_L1.2461.00
63_I93_T1.2441.00
25_V39_C1.2401.00
26_E108_L1.2301.00
34_I103_V1.2251.00
64_L68_K1.2151.00
69_E75_R1.2121.00
32_S134_I1.2101.00
29_V134_I1.1921.00
71_T94_F1.1861.00
52_A101_F1.1731.00
39_C108_L1.1731.00
42_F52_A1.1721.00
11_S24_Q1.1661.00
44_A131_T1.1221.00
16_F68_K1.1021.00
68_K73_P1.0961.00
16_F64_L1.0850.99
61_E65_T1.0840.99
6_D28_I1.0820.99
85_N122_D1.0790.99
103_V134_I1.0780.99
58_G61_E1.0760.99
66_K69_E1.0740.99
21_I130_I1.0670.99
18_L67_I1.0550.99
16_F73_P1.0370.99
66_K77_W1.0260.99
38_I135_L1.0250.99
7_D104_R1.0130.99
71_T77_W1.0110.99
8_I130_I1.0070.99
23_D27_Q1.0060.99
44_A109_V1.0040.99
48_A118_L1.0020.99
66_K71_T1.0000.99
102_P133_E0.9740.99
65_T69_E0.9710.99
28_I134_I0.9590.99
29_V32_S0.9420.98
74_S83_D0.9400.98
29_V103_V0.9270.98
95_L121_L0.9180.98
21_I25_V0.9120.98
43_V92_A0.9110.98
26_E30_E0.8940.98
30_E107_K0.8920.98
101_F116_I0.8820.98
67_I119_V0.8750.98
71_T90_L0.8740.98
41_I99_R0.8740.98
9_Y126_S0.8740.98
27_Q30_E0.8680.97
51_V119_V0.8650.97
66_K75_R0.8610.97
5_F133_E0.8570.97
73_P123_G0.8530.97
30_E33_G0.8500.97
23_D26_E0.8470.97
29_V108_L0.8460.97
55_H117_F0.8410.97
10_V19_V0.8360.97
76_S80_N0.8330.97
73_P77_W0.8320.97
109_V131_T0.8320.97
51_V96_G0.8290.97
73_P91_G0.8170.96
39_C103_V0.8020.96
5_F36_N0.8000.96
52_A97_A0.7920.96
43_V50_I0.7850.95
7_D109_V0.7800.95
50_I99_R0.7780.95
72_E75_R0.7710.95
36_N105_E0.7690.95
42_F101_F0.7690.95
42_F102_P0.7540.94
56_E59_L0.7510.94
18_L117_F0.7480.94
60_M64_L0.7460.94
101_F108_L0.7410.94
52_A110_R0.7350.93
39_C134_I0.7290.93
40_L102_P0.7250.93
47_T122_D0.7200.93
68_K91_G0.7140.92
28_I32_S0.7110.92
43_V118_L0.7090.92
77_W80_N0.7060.92
13_A24_Q0.7050.92
102_P131_T0.7010.92
16_F87_H0.6970.92
25_V41_I0.6970.92
36_N133_E0.6940.91
54_E113_W0.6930.91
35_K106_G0.6880.91
49_A99_R0.6800.90
86_A90_L0.6740.90
8_I28_I0.6600.89
38_I133_E0.6580.89
5_F109_V0.6540.89
82_I86_A0.6490.88
17_E120_E0.6290.87
93_T96_G0.6240.86
10_V24_Q0.6210.86
11_S126_S0.6190.86
42_F98_E0.6150.86
47_T85_N0.6080.85
55_H60_M0.6060.85
28_I31_K0.6030.84
41_I50_I0.5990.84
23_D107_K0.5980.84
18_L63_I0.5940.84
26_E29_V0.5930.83
24_Q28_I0.5860.83
40_L98_E0.5860.83
79_H113_W0.5830.82
45_H89_H0.5810.82
49_A119_V0.5810.82
18_L51_V0.5810.82
41_I116_I0.5790.82
23_D30_E0.5690.81
25_V28_I0.5680.81
45_H53_N0.5670.81
12_T126_S0.5660.81
48_A84_D0.5630.80
18_L60_M0.5610.80
56_E81_L0.5590.80
36_N103_V0.5520.79
58_G115_N0.5510.79
60_M71_T0.5500.79
18_L53_N0.5480.78
12_T19_V0.5470.78
63_I117_F0.5460.78
77_W90_L0.5450.78
36_N135_L0.5440.78
101_F110_R0.5440.78
59_L86_A0.5420.78
78_K81_L0.5400.77
50_I116_I0.5400.77
75_R90_L0.5320.76
42_F99_R0.5300.76
84_D113_W0.5280.76
91_G119_V0.5250.75
34_I37_G0.5250.75
80_N91_G0.5200.75
53_N117_F0.5180.74
79_H82_I0.5160.74
54_E59_L0.5160.74
36_N134_I0.5150.74
63_I74_S0.5150.74
29_V34_I0.5120.74
52_A117_F0.5080.73
53_N63_I0.5070.73
26_E105_E0.5070.73
63_I90_L0.5040.72
102_P109_V0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vphA 4 1 100 0.032 Contact Map
2p6cA 3 0.9927 100 0.045 Contact Map
1ve0A 3 0.9781 100 0.049 Contact Map
1vmjA 4 0.9854 100 0.054 Contact Map
2p6hA 3 0.9781 100 0.061 Contact Map
1vmfA 3 0.9781 100 0.108 Contact Map
1vmhA 3 0.9343 100 0.118 Contact Map
2cu5A 3 0.927 100 0.136 Contact Map
3uguA 1 0.292 15.2 0.945 Contact Map
2w1iA 1 0.2409 9.6 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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