GREMLIN Database
Q97VS6 - Enoyl CoA hydratase (PaaF-5)
UniProt: Q97VS6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (237)
Sequences: 30289 (20128)
Seq/√Len: 1307.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_T163_S3.1861.00
124_K180_A3.1811.00
177_I187_E3.0851.00
122_A175_V2.9281.00
187_E190_R2.7601.00
100_C117_C2.7441.00
14_W189_E2.6201.00
42_N95_K2.4581.00
39_G90_S2.4231.00
5_L18_N2.3471.00
162_D194_K2.3221.00
23_L57_R2.3051.00
125_D181_N2.2381.00
156_R162_D2.2041.00
8_K13_C2.2021.00
168_E171_M2.1751.00
165_T168_E2.1541.00
217_I220_A2.1491.00
154_I172_I2.0871.00
134_R198_I2.0841.00
8_K44_D2.0381.00
14_W53_T2.0151.00
23_L58_A1.9761.00
124_K167_E1.9671.00
6_L13_C1.8851.00
11_D48_S1.8791.00
158_A206_I1.8771.00
107_Y129_S1.8771.00
101_A188_V1.8731.00
35_A90_S1.8431.00
29_E33_L1.8311.00
156_R176_D1.8191.00
18_N55_N1.8081.00
238_K242_N1.7901.00
121_I179_V1.7871.00
101_A185_L1.7861.00
16_T55_N1.7721.00
183_D186_T1.7711.00
13_C41_C1.7211.00
16_T53_T1.7081.00
189_E193_E1.6791.00
40_E44_D1.6771.00
124_K181_N1.6721.00
50_I94_L1.6601.00
168_E172_I1.6391.00
118_D207_K1.6261.00
120_V149_I1.6001.00
167_E171_M1.5491.00
121_I191_Q1.5471.00
13_C47_I1.5441.00
32_S83_T1.5391.00
183_D187_E1.5381.00
122_A128_F1.5101.00
114_L120_V1.4831.00
123_V181_N1.4801.00
41_C50_I1.4771.00
156_R177_I1.4651.00
49_A192_L1.4641.00
120_V153_S1.4521.00
179_V187_E1.4511.00
42_N90_S1.4511.00
10_K193_E1.4491.00
6_L41_C1.4271.00
15_I37_H1.4251.00
92_V146_G1.3981.00
102_V114_L1.3921.00
53_T103_N1.3911.00
9_R189_E1.3861.00
103_N123_V1.3851.00
170_K178_V1.3811.00
102_V106_A1.3751.00
9_R193_E1.3601.00
89_E93_D1.3601.00
103_N125_D1.3471.00
57_R103_N1.3421.00
5_L55_N1.3321.00
111_C130_I1.3261.00
91_L98_L1.3081.00
38_L94_L1.3051.00
28_K67_A1.2881.00
9_R14_W1.2811.00
162_D168_E1.2751.00
157_L164_I1.2741.00
19_R22_K1.2721.00
35_A39_G1.2721.00
184_L188_V1.2691.00
133_G161_G1.2431.00
129_S163_S1.2381.00
27_D30_S1.2271.00
235_E242_N1.2251.00
42_N94_L1.2101.00
185_L188_V1.2081.00
151_G154_I1.2021.00
185_L189_E1.2001.00
208_N212_D1.1941.00
154_I168_E1.1861.00
35_A86_S1.1861.00
233_A237_M1.1821.00
14_W185_L1.1671.00
105_L127_T1.1641.00
89_E219_K1.1581.00
33_L37_H1.1491.00
53_T185_L1.1491.00
153_S176_D1.1471.00
58_A105_L1.1381.00
17_L30_S1.1381.00
198_I203_I1.1381.00
8_K40_E1.1311.00
205_T226_L1.1301.00
7_E16_T1.1231.00
22_K66_N1.1231.00
123_V184_L1.1051.00
60_S110_G1.1021.00
166_A178_V1.0951.00
216_K220_A1.0921.00
17_L60_S1.0891.00
84_L141_I1.0881.00
164_I172_I1.0711.00
8_K46_S1.0591.00
33_L36_N1.0401.00
7_E14_W1.0291.00
36_N40_E1.0251.00
150_L154_I1.0221.00
28_K32_S1.0181.00
112_E143_I1.0171.00
186_T190_R1.0121.00
50_I96_K1.0111.00
19_R64_D1.0001.00
220_A223_E0.9911.00
119_I191_Q0.9891.00
5_L16_T0.9871.00
98_L117_C0.9731.00
192_L196_K0.9691.00
217_I221_V0.9661.00
201_S232_S0.9651.00
14_W51_V0.9541.00
56_G103_N0.9471.00
51_V188_V0.9401.00
127_T165_T0.9381.00
95_K204_L0.9351.00
170_K175_V0.9301.00
124_K178_V0.9281.00
112_E132_E0.9261.00
111_C128_F0.9241.00
47_I96_K0.9191.00
216_K224_L0.9191.00
37_H40_E0.9171.00
149_I153_S0.9111.00
53_T101_A0.9081.00
167_E170_K0.8991.00
234_K238_K0.8971.00
180_A183_D0.8971.00
103_N184_L0.8891.00
50_I98_L0.8831.00
101_A184_L0.8661.00
23_L61_A0.8641.00
200_R204_L0.8621.00
108_G131_P0.8571.00
78_L82_N0.8561.00
102_V120_V0.8511.00
102_V128_F0.8481.00
12_V49_A0.8481.00
123_V182_E0.8481.00
138_I227_M0.8471.00
132_E140_P0.8431.00
45_Q96_K0.8351.00
31_W87_A0.8321.00
187_E191_Q0.8241.00
133_G206_I0.8221.00
150_L157_L0.8151.00
52_L117_C0.8141.00
152_R214_K0.8101.00
119_I176_D0.8101.00
199_D232_S0.8091.00
189_E192_L0.8011.00
32_S36_N0.7951.00
186_T189_E0.7941.00
205_T208_N0.7881.00
93_D219_K0.7861.00
38_L91_L0.7861.00
190_R194_K0.7851.00
8_K47_I0.7841.00
235_E239_E0.7801.00
157_L172_I0.7791.00
170_K177_I0.7761.00
107_Y163_S0.7731.00
132_E139_P0.7711.00
39_G86_S0.7691.00
35_A83_T0.7691.00
42_N96_K0.7681.00
156_R160_T0.7651.00
236_K239_E0.7641.00
39_G43_N0.7641.00
212_D216_K0.7631.00
66_N241_M0.7601.00
15_I50_I0.7581.00
134_R163_S0.7561.00
177_I191_Q0.7531.00
188_V192_L0.7531.00
166_A175_V0.7511.00
35_A87_A0.7491.00
95_K208_N0.7491.00
28_K83_T0.7471.00
41_C47_I0.7421.00
115_L174_L0.7421.00
27_D67_A0.7371.00
212_D224_L0.7371.00
112_E140_P0.7351.00
219_K223_E0.7321.00
58_A103_N0.7301.00
231_N234_K0.7301.00
26_L30_S0.7271.00
19_R27_D0.7261.00
194_K198_I0.7201.00
94_L98_L0.7181.00
218_R222_M0.7161.00
139_P206_I0.7161.00
169_A174_L0.7131.00
41_C96_K0.7121.00
190_R193_E0.7111.00
88_V116_F0.7101.00
147_Y150_L0.7011.00
6_L37_H0.7001.00
48_S200_R0.6981.00
158_A210_L0.6911.00
94_L97_P0.6891.00
6_L40_E0.6871.00
23_L105_L0.6821.00
179_V184_L0.6791.00
195_I203_I0.6771.00
128_F175_V0.6751.00
19_R25_A0.6721.00
160_T191_Q0.6691.00
121_I188_V0.6681.00
103_N181_N0.6671.00
216_K221_V0.6641.00
82_N86_S0.6641.00
205_T227_M0.6641.00
52_L98_L0.6631.00
237_M241_M0.6621.00
29_E32_S0.6621.00
102_V126_A0.6611.00
151_G155_A0.6601.00
232_S236_K0.6591.00
121_I177_I0.6541.00
8_K11_D0.6481.00
193_E197_S0.6481.00
221_V224_L0.6431.00
129_S161_G0.6431.00
44_D47_I0.6411.00
30_S33_L0.6411.00
145_L221_V0.6411.00
122_A126_A0.6401.00
12_V51_V0.6391.00
206_I209_W0.6361.00
149_I176_D0.6361.00
107_Y131_P0.6351.00
138_I209_W0.6321.00
51_V189_E0.6321.00
121_I184_L0.6321.00
51_V101_A0.6311.00
112_E142_A0.6311.00
63_D68_M0.6301.00
36_N39_G0.6241.00
152_R211_R0.6231.00
175_V178_V0.6181.00
137_L233_A0.6171.00
11_D46_S0.6141.00
159_L203_I0.6141.00
12_V189_E0.6131.00
99_V192_L0.6121.00
37_H41_C0.6121.00
132_E142_A0.6101.00
130_I143_I0.6091.00
39_G42_N0.6061.00
218_R221_V0.6061.00
200_R203_I0.6031.00
154_I170_K0.6031.00
108_G130_I0.6031.00
167_E178_V0.5981.00
100_C120_V0.5971.00
164_I169_A0.5961.00
112_E130_I0.5951.00
49_A99_V0.5931.00
121_I187_E0.5911.00
69_L238_K0.5911.00
49_A196_K0.5911.00
79_D83_T0.5901.00
201_S230_G0.5861.00
44_D96_K0.5861.00
207_K211_R0.5851.00
150_L155_A0.5851.00
162_D177_I0.5831.00
12_V192_L0.5831.00
156_R168_E0.5821.00
109_G141_I0.5811.00
72_K76_D0.5781.00
152_R210_L0.5751.00
111_C115_L0.5741.00
233_A236_K0.5731.00
105_L163_S0.5711.00
38_L90_S0.5701.00
191_Q194_K0.5691.00
34_L87_A0.5661.00
103_N126_A0.5631.00
150_L172_I0.5631.00
231_N235_E0.5621.00
15_I52_L0.5611.00
112_E146_G0.5591.00
109_G112_E0.5591.00
130_I158_A0.5561.00
140_P143_I0.5521.00
63_D109_G0.5501.00
22_K64_D0.5451.00
165_T171_M0.5431.00
160_T195_I0.5421.00
209_W224_L0.5411.00
119_I195_I0.5401.00
86_S89_E0.5391.00
145_L148_L0.5381.00
238_K241_M0.5371.00
235_E238_K0.5351.00
166_A170_K0.5351.00
133_G198_I0.5351.00
183_D190_R0.5341.00
114_L117_C0.5321.00
177_I190_R0.5311.00
25_A61_A0.5291.00
48_S196_K0.5281.00
123_V126_A0.5281.00
111_C174_L0.5281.00
26_L31_W0.5271.00
6_L15_I0.5261.00
169_A175_V0.5251.00
201_S227_M0.5231.00
86_S90_S0.5221.00
47_I50_I0.5211.00
227_M230_G0.5201.00
125_D166_A0.5191.00
139_P142_A0.5191.00
26_L109_G0.5181.00
15_I38_L0.5171.00
27_D64_D0.5171.00
38_L98_L0.5161.00
106_A111_C0.5141.00
154_I171_M0.5121.00
194_K197_S0.5091.00
139_P158_A0.5091.00
96_K200_R0.5061.00
156_R191_Q0.5041.00
108_G140_P0.5041.00
31_W35_A0.5031.00
120_V175_V0.5031.00
128_F169_A0.5031.00
239_E242_N0.5021.00
51_V185_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qmjA 3 0.8496 100 0.118 Contact Map
4lk5A 3 0.9634 100 0.118 Contact Map
4mouA 3 1 100 0.119 Contact Map
2vx2A 3 1 100 0.122 Contact Map
3kqfA 3 0.9959 100 0.123 Contact Map
4olqA 3 1 100 0.124 Contact Map
3peaA 3 0.9959 100 0.124 Contact Map
4k3wA 3 1 100 0.125 Contact Map
4k2nA 3 0.9959 100 0.126 Contact Map
4jfcA 3 0.9959 100 0.126 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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