GREMLIN Database
Q97VS4 - Glucan phosphorylase, putative (GlgP or malP)
UniProt: Q97VS4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (451)
Sequences: 2753 (1365)
Seq/√Len: 64.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_G163_R5.1141.00
277_K307_F4.8641.00
257_M439_Y4.5831.00
142_F206_I4.5311.00
296_L331_I4.4061.00
125_K129_N4.3701.00
286_I312_G4.3461.00
437_K441_V4.3211.00
207_E231_R4.2721.00
398_D452_F3.6851.00
261_I276_D3.5581.00
256_F446_Y3.4541.00
256_F442_G3.2341.00
114_D184_K2.9431.00
28_K458_L2.9261.00
233_V458_L2.9201.00
169_P218_H2.8801.00
44_L104_N2.8241.00
341_I348_F2.7881.00
304_D433_V2.7621.00
271_L309_I2.7551.00
237_I379_I2.7451.00
388_R408_D2.7101.00
131_I143_V2.6781.00
263_V266_D2.6711.00
217_K221_R2.6281.00
281_A356_S2.6061.00
358_I385_V2.5911.00
457_R461_E2.5791.00
256_F443_Y2.5381.00
32_A39_Y2.5351.00
379_I449_F2.5261.00
396_I399_G2.4441.00
283_L352_A2.4361.00
59_E326_R2.3471.00
422_K426_E2.3361.00
249_M266_D2.3361.00
249_M262_E2.3291.00
71_E74_V2.3181.00
261_I265_R2.3111.00
460_K464_Y2.2821.00
414_P418_Y2.2561.00
437_K440_E2.1911.00
278_P358_I2.1861.00
357_D439_Y2.1471.00
396_I402_G2.1431.00
202_L208_G2.1291.00
378_G449_F2.1081.00
132_S137_W2.0751.00
71_E75_G2.0721.00
425_E432_K2.0651.00
77_Q100_N2.0581.00
383_P403_W2.0251.00
326_R330_E2.0071.00
132_S158_Y1.9901.00
31_A455_I1.9801.00
296_L327_K1.9731.00
265_R269_K1.9701.00
269_K273_K1.9151.00
170_A367_W1.9141.00
151_A201_G1.9091.00
383_P441_V1.9051.00
349_M353_I1.8911.00
420_D423_E1.8911.00
377_A382_I1.8641.00
388_R396_I1.8581.00
152_F182_F1.8391.00
249_M263_V1.8251.00
213_K217_K1.8221.00
32_A37_I1.8001.00
461_E464_Y1.7971.00
93_V96_A1.7851.00
270_K348_F1.7761.00
28_K459_M1.7561.00
176_T194_H1.7561.00
208_G229_K1.7461.00
44_L123_L1.7421.00
385_V435_L1.7411.00
90_T93_V1.7390.99
344_A353_I1.7320.99
283_L377_A1.7320.99
154_P158_Y1.7310.99
156_L159_F1.7260.99
301_D430_K1.7160.99
135_I138_D1.7120.99
429_N433_V1.6730.99
388_R404_L1.6480.99
128_E158_Y1.6350.99
190_F193_D1.6340.99
251_K255_D1.5920.99
217_K220_S1.5880.99
408_D411_I1.5780.99
158_Y163_R1.5780.99
265_R275_T1.5510.99
270_K351_L1.5490.99
154_P159_F1.5330.99
145_M153_L1.5310.99
439_Y442_G1.5220.99
297_R301_D1.5150.99
171_P312_G1.5090.99
81_V122_L1.5050.99
297_R430_K1.4930.98
151_A200_I1.4900.98
37_I463_G1.4730.98
258_K262_E1.4680.98
52_D343_G1.4570.98
323_E326_R1.4400.98
180_H183_K1.4390.98
274_D337_N1.4370.98
156_L160_P1.4290.98
266_D351_L1.4250.98
356_S382_I1.4220.98
260_R442_G1.4130.98
137_W141_K1.4090.98
154_P160_P1.4080.98
424_Y431_I1.3950.98
439_Y443_Y1.3840.97
31_A35_L1.3680.97
293_D327_K1.3580.97
129_N158_Y1.3560.97
423_E426_E1.3520.97
156_L161_R1.3480.97
283_L353_I1.3360.97
42_I127_A1.3360.97
298_L308_F1.3220.97
123_L152_F1.3080.96
155_L159_F1.3050.96
403_W441_V1.3030.96
300_D433_V1.3000.96
86_Y94_I1.2990.96
114_D181_L1.2860.96
15_Q50_Y1.2780.96
423_E427_F1.2760.96
288_G320_S1.2760.96
161_R188_F1.2690.96
241_R346_A1.2570.95
283_L311_G1.2510.95
216_L231_R1.2490.95
216_L232_A1.2210.95
319_Y323_E1.2210.95
253_L259_K1.2190.95
73_T76_D1.2160.95
233_V461_E1.2090.94
260_R382_I1.2050.94
431_I434_A1.2000.94
118_Y185_E1.1990.94
180_H193_D1.1980.94
268_I275_T1.1970.94
154_P161_R1.1940.94
239_I379_I1.1870.94
83_Y131_I1.1830.94
310_I328_F1.1830.94
396_I404_L1.1820.94
279_T309_I1.1800.94
262_E265_R1.1710.93
71_E78_R1.1670.93
401_N448_T1.1570.93
137_W155_L1.1550.93
274_D277_K1.1520.93
219_V223_F1.1510.93
174_H198_T1.1490.93
207_E233_V1.1380.92
341_I352_A1.1380.92
383_P449_F1.1370.92
154_P162_Y1.1360.92
210_V216_L1.1330.92
216_L220_S1.1320.92
84_L88_L1.1220.92
293_D324_I1.1210.92
331_I335_R1.1200.92
54_E63_H1.1180.92
249_M259_K1.1180.92
180_H192_L1.1180.92
92_K96_A1.1110.91
56_K61_L1.1110.91
428_I431_I1.1100.91
287_T292_P1.1080.91
397_N452_F1.1080.91
55_G329_K1.1070.91
182_F195_V1.1070.91
82_E87_T1.0810.90
282_W295_I1.0780.90
47_R105_D1.0770.90
45_L68_W1.0740.90
243_R379_I1.0720.90
383_P438_Y1.0660.90
444_N448_T1.0600.89
384_S445_A1.0590.89
455_I459_M1.0500.89
267_S271_L1.0440.89
48_R65_N1.0420.89
120_C152_F1.0410.89
310_I338_V1.0320.88
259_K263_V1.0260.88
411_I414_P1.0210.88
132_S136_G1.0200.88
458_L461_E1.0160.87
344_A349_M1.0150.87
341_I351_L1.0120.87
31_A459_M1.0090.87
271_L341_I1.0040.87
50_Y316_P1.0000.86
156_L162_Y0.9970.86
429_N432_K0.9960.86
301_D304_D0.9920.86
202_L223_F0.9910.86
124_A152_F0.9900.86
124_A151_A0.9810.85
180_H184_K0.9770.85
216_L219_V0.9760.85
244_N251_K0.9750.85
383_P445_A0.9700.85
383_P442_G0.9680.85
261_I275_T0.9660.85
242_W344_A0.9660.85
63_H322_V0.9660.85
37_I460_K0.9620.84
176_T196_V0.9580.84
99_L118_Y0.9540.84
246_S262_E0.9520.84
182_F186_F0.9490.83
330_E333_D0.9450.83
85_A92_K0.9440.83
395_I402_G0.9430.83
131_I134_R0.9410.83
128_E143_V0.9400.83
103_L118_Y0.9390.83
214_K365_S0.9370.83
303_K334_K0.9320.82
361_F382_I0.9300.82
221_R225_Q0.9290.82
222_T413_L0.9270.82
231_R458_L0.9190.81
303_K336_N0.9140.81
277_K337_N0.9110.81
121_L125_K0.9080.81
385_V430_K0.9030.80
131_I141_K0.9020.80
216_L233_V0.9020.80
328_F338_V0.9000.80
60_L326_R0.8930.80
112_S317_K0.8920.79
111_N118_Y0.8910.79
154_P157_R0.8900.79
174_H223_F0.8880.79
415_F418_Y0.8860.79
190_F194_H0.8820.79
81_V87_T0.8820.79
208_G228_H0.8810.79
366_G413_L0.8800.79
274_D307_F0.8790.78
123_L343_G0.8770.78
60_L322_V0.8760.78
295_I308_F0.8650.77
440_E444_N0.8640.77
361_F384_S0.8640.77
357_D442_G0.8610.77
388_R399_G0.8570.77
304_D432_K0.8560.77
125_K158_Y0.8560.77
137_W159_F0.8480.76
299_I303_K0.8470.76
301_D432_K0.8470.76
410_D414_P0.8440.76
401_N441_V0.8430.75
29_F39_Y0.8430.75
399_G402_G0.8420.75
356_S377_A0.8400.75
54_E258_K0.8380.75
421_N425_E0.8380.75
202_L227_M0.8360.75
425_E428_I0.8360.75
330_E334_K0.8350.75
28_K233_V0.8320.75
199_D227_M0.8320.75
120_C151_A0.8310.74
327_K330_E0.8290.74
311_G342_R0.8290.74
279_T307_F0.8290.74
347_N351_L0.8270.74
257_M436_N0.8260.74
158_Y162_Y0.8250.74
407_E415_F0.8230.74
151_A204_A0.8230.74
300_D303_K0.8220.74
196_V199_D0.8210.74
133_E160_P0.8200.73
29_F41_V0.8120.73
251_K254_D0.8120.73
16_N95_F0.8120.73
60_L67_E0.8090.72
179_S183_K0.8080.72
424_Y427_F0.8080.72
256_F439_Y0.8080.72
258_K261_I0.8070.72
202_L230_I0.8060.72
124_A153_L0.8050.72
378_G382_I0.8050.72
191_P196_V0.8040.72
178_P181_L0.8040.72
348_F352_A0.8040.72
58_R330_E0.8010.72
267_S281_A0.7990.72
85_A88_L0.7990.72
297_R421_N0.7990.72
220_S232_A0.7980.71
171_P223_F0.7970.71
79_I103_L0.7970.71
283_L344_A0.7960.71
443_Y446_Y0.7930.71
81_V86_Y0.7910.71
71_E76_D0.7900.71
281_A377_A0.7880.70
31_A456_D0.7820.70
90_T97_N0.7820.70
231_R461_E0.7800.70
257_M261_I0.7790.70
385_V403_W0.7790.70
91_A95_F0.7740.69
43_T454_S0.7740.69
23_I346_A0.7740.69
267_S270_K0.7730.69
364_Y420_D0.7700.69
213_K452_F0.7680.68
262_E266_D0.7660.68
436_N439_Y0.7590.68
307_F339_I0.7570.67
20_G24_L0.7520.67
35_L460_K0.7500.67
26_G72_I0.7460.66
258_K269_K0.7430.66
219_V225_Q0.7410.66
15_Q345_D0.7410.66
365_S387_S0.7400.66
415_F419_D0.7400.66
294_F373_S0.7400.66
311_G348_F0.7400.66
294_F424_Y0.7390.66
154_P204_A0.7390.66
414_P417_V0.7380.65
270_K352_A0.7370.65
13_I350_K0.7360.65
214_K409_R0.7360.65
90_T95_F0.7350.65
300_D304_D0.7320.65
424_Y428_I0.7320.65
436_N443_Y0.7310.65
308_F358_I0.7300.65
10_G351_L0.7290.64
128_E133_E0.7290.64
82_E89_N0.7280.64
320_S324_I0.7270.64
359_W384_S0.7270.64
58_R275_T0.7250.64
169_P366_G0.7230.64
298_L301_D0.7220.64
320_S323_E0.7220.64
261_I272_G0.7200.63
72_I75_G0.7200.63
274_D305_D0.7180.63
423_E428_I0.7170.63
126_V129_N0.7170.63
296_L328_F0.7140.63
189_E378_G0.7140.63
281_A352_A0.7120.63
144_D238_E0.7100.62
366_G416_N0.7060.62
30_Y48_R0.7040.62
213_K397_N0.7040.62
267_S339_I0.7020.62
275_T279_T0.6990.61
102_N105_D0.6980.61
56_K59_E0.6980.61
165_V209_I0.6960.61
82_E86_Y0.6960.61
97_N127_A0.6960.61
114_D185_E0.6960.61
98_P102_N0.6940.61
109_V150_P0.6920.60
352_A373_S0.6920.60
86_Y89_N0.6910.60
329_K332_S0.6910.60
373_S386_A0.6900.60
211_V215_M0.6890.60
62_S322_V0.6890.60
54_E342_R0.6870.60
332_S336_N0.6870.60
75_G86_Y0.6870.60
152_F186_F0.6840.60
144_D288_G0.6840.60
30_Y241_R0.6820.59
436_N440_E0.6810.59
269_K276_D0.6810.59
261_I264_K0.6790.59
415_F424_Y0.6780.59
303_K335_R0.6760.59
223_F345_D0.6720.58
440_E443_Y0.6710.58
431_I435_L0.6710.58
78_R270_K0.6710.58
244_N255_D0.6700.58
202_L224_P0.6700.58
110_E317_K0.6690.58
311_G352_A0.6680.58
74_V186_F0.6650.57
28_K39_Y0.6640.57
169_P224_P0.6640.57
132_S135_I0.6630.57
413_L416_N0.6630.57
239_I454_S0.6620.57
279_T295_I0.6580.57
74_V79_I0.6580.57
260_R446_Y0.6540.56
285_R289_Y0.6540.56
201_G357_D0.6530.56
267_S355_A0.6530.56
37_I66_K0.6530.56
407_E411_I0.6510.56
214_K217_K0.6490.56
120_C443_Y0.6490.56
212_S239_I0.6480.55
89_N94_I0.6470.55
428_I432_K0.6460.55
270_K341_I0.6450.55
114_D118_Y0.6440.55
386_A457_R0.6440.55
426_E429_N0.6430.55
274_D279_T0.6430.55
15_Q65_N0.6430.55
366_G386_A0.6430.55
126_V308_F0.6420.55
413_L417_V0.6420.55
117_F152_F0.6390.54
78_R84_L0.6380.54
425_E429_N0.6370.54
96_A99_L0.6370.54
125_K189_E0.6370.54
51_A62_S0.6350.54
373_S384_S0.6340.54
62_S67_E0.6320.54
358_I434_A0.6300.53
245_P311_G0.6290.53
399_G408_D0.6280.53
169_P222_T0.6280.53
213_K232_A0.6280.53
127_A169_P0.6270.53
427_F431_I0.6260.53
112_S178_P0.6260.53
379_I450_P0.6240.53
39_Y112_S0.6220.52
43_T107_L0.6220.52
81_V89_N0.6210.52
118_Y126_V0.6210.52
427_F435_L0.6210.52
359_W374_F0.6190.52
32_A237_I0.6170.52
249_M258_K0.6160.52
35_L233_V0.6160.52
247_L256_F0.6150.52
393_T409_R0.6140.52
93_V97_N0.6140.52
21_L24_L0.6140.52
74_V80_M0.6130.51
360_T384_S0.6130.51
148_A197_M0.6120.51
418_Y422_K0.6120.51
91_A94_I0.6120.51
145_M342_R0.6110.51
426_E432_K0.6100.51
268_I271_L0.6080.51
32_A38_N0.6080.51
126_V169_P0.6080.51
310_I342_R0.6080.51
169_P458_L0.6070.51
156_L204_A0.6060.51
288_G292_P0.6060.51
327_K331_I0.6060.51
139_K413_L0.6060.51
446_Y450_P0.6060.51
92_K95_F0.6060.51
262_E269_K0.6050.50
257_M442_G0.6040.50
305_D455_I0.6030.50
248_N252_D0.6030.50
72_I79_I0.6010.50
61_L123_L0.6010.50
353_I373_S0.6000.50
18_A287_T0.6000.50
79_I104_N0.6000.50
73_T82_E0.5990.50
420_D427_F0.5980.50
65_N68_W0.5980.50
72_I76_D0.5940.49
302_L399_G0.5940.49
120_C245_P0.5930.49
218_H221_R0.5930.49
116_R148_A0.5920.49
216_L230_I0.5920.49
183_K193_D0.5920.49
64_L67_E0.5910.49
146_Q209_I0.5910.49
240_S456_D0.5900.49
398_D434_A0.5900.49
282_W311_G0.5890.49
280_I358_I0.5880.48
364_Y419_D0.5870.48
264_K279_T0.5860.48
159_F162_Y0.5850.48
68_W454_S0.5850.48
10_G24_L0.5840.48
370_S391_A0.5840.48
297_R300_D0.5840.48
52_D63_H0.5830.48
40_T134_R0.5830.48
260_R264_K0.5830.48
85_A90_T0.5820.48
48_R81_V0.5820.48
91_A101_T0.5810.48
144_D256_F0.5810.48
286_I292_P0.5810.48
44_L122_L0.5790.47
280_I360_T0.5780.47
35_L455_I0.5780.47
16_N43_T0.5770.47
114_D178_P0.5770.47
388_R402_G0.5760.47
153_L324_I0.5750.47
266_D341_I0.5740.47
378_G445_A0.5740.47
257_M357_D0.5740.47
146_Q165_V0.5720.47
45_L126_V0.5700.46
352_A377_A0.5690.46
52_D66_K0.5690.46
56_K60_L0.5680.46
138_D141_K0.5670.46
12_D16_N0.5660.46
37_I72_I0.5660.46
24_L28_K0.5650.46
34_R238_E0.5650.46
252_D464_Y0.5630.46
131_I135_I0.5620.45
233_V459_M0.5610.45
212_S349_M0.5610.45
89_N114_D0.5610.45
265_R268_I0.5600.45
244_N263_V0.5600.45
103_L122_L0.5600.45
145_M366_G0.5590.45
111_N115_E0.5590.45
52_D69_E0.5580.45
411_I418_Y0.5570.45
151_A312_G0.5570.45
323_E327_K0.5560.45
178_P193_D0.5550.45
180_H273_K0.5540.45
271_L352_A0.5540.45
78_R86_Y0.5530.44
38_N66_K0.5520.44
75_G82_E0.5510.44
147_E150_P0.5510.44
427_F432_K0.5500.44
345_D348_F0.5490.44
280_I295_I0.5490.44
26_G96_A0.5490.44
110_E212_S0.5480.44
57_Q333_D0.5480.44
285_R290_K0.5470.44
171_P286_I0.5470.44
202_L219_V0.5450.44
316_P320_S0.5450.44
61_L69_E0.5440.43
361_F373_S0.5440.43
80_M201_G0.5440.43
10_G458_L0.5430.43
447_K450_P0.5420.43
10_G34_R0.5420.43
53_G119_K0.5410.43
210_V370_S0.5410.43
111_N453_C0.5410.43
198_T202_L0.5400.43
71_E80_M0.5400.43
299_I331_I0.5400.43
198_T219_V0.5400.43
260_R439_Y0.5390.43
139_K437_K0.5390.43
227_M323_E0.5390.43
367_W416_N0.5380.43
237_I243_R0.5380.43
351_L355_A0.5380.43
50_Y127_A0.5370.43
54_E273_K0.5370.43
72_I83_Y0.5360.42
151_A431_I0.5360.42
315_H325_E0.5360.42
96_A170_A0.5350.42
276_D414_P0.5350.42
127_A144_D0.5350.42
19_G24_L0.5340.42
100_N127_A0.5340.42
365_S386_A0.5330.42
70_N112_S0.5330.42
370_S455_I0.5330.42
79_I86_Y0.5330.42
84_L97_N0.5320.42
217_K269_K0.5310.42
250_V254_D0.5300.42
258_K265_R0.5300.42
115_E406_G0.5300.42
60_L64_L0.5300.42
92_K97_N0.5290.42
366_G409_R0.5290.42
346_A384_S0.5290.42
179_S190_F0.5290.42
101_T104_N0.5290.42
19_G22_G0.5280.42
95_F124_A0.5280.42
90_T96_A0.5270.41
196_V449_F0.5260.41
242_W347_N0.5260.41
205_S208_G0.5250.41
213_K393_T0.5250.41
20_G211_V0.5250.41
11_L301_D0.5240.41
285_R369_A0.5240.41
81_V84_L0.5240.41
92_K464_Y0.5240.41
243_R250_V0.5230.41
232_A311_G0.5230.41
42_I123_L0.5220.41
36_G120_C0.5220.41
28_K31_A0.5220.41
308_F379_I0.5190.41
249_M253_L0.5190.41
127_A288_G0.5190.41
397_N401_N0.5190.41
170_A173_G0.5190.41
167_H234_T0.5180.40
82_E91_A0.5180.40
421_N445_A0.5170.40
348_F351_L0.5170.40
200_I204_A0.5160.40
411_I419_D0.5150.40
399_G444_N0.5140.40
50_Y307_F0.5130.40
29_F32_A0.5130.40
452_F457_R0.5120.40
50_Y110_E0.5120.40
366_G415_F0.5110.40
117_F340_Y0.5100.40
116_R120_C0.5100.40
262_E436_N0.5090.39
268_I307_F0.5090.39
309_I339_I0.5090.39
175_P223_F0.5080.39
74_V86_Y0.5080.39
123_L223_F0.5080.39
425_E445_A0.5080.39
96_A123_L0.5070.39
429_N435_L0.5070.39
61_L329_K0.5070.39
128_E160_P0.5060.39
83_Y86_Y0.5060.39
283_L307_F0.5050.39
224_P233_V0.5040.39
100_N288_G0.5040.39
98_P105_D0.5030.39
424_Y430_K0.5030.39
268_I272_G0.5020.39
146_Q215_M0.5020.39
104_N419_D0.5020.39
35_L459_M0.5020.39
47_R101_T0.5020.39
319_Y322_V0.5010.39
267_S309_I0.5010.39
253_L256_F0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ygpA 2 0.9957 100 0.265 Contact Map
4bqeA 2 0.9978 100 0.278 Contact Map
2gj4A 2 0.9849 100 0.317 Contact Map
1l5wA 2 0.9978 100 0.324 Contact Map
2c4mA 4 0.9978 100 0.361 Contact Map
4l22A 1 0.9978 100 0.366 Contact Map
3vueA 1 0.914 100 0.801 Contact Map
3nb0A 4 0.9398 100 0.822 Contact Map
4qlbA 3 0.9376 100 0.828 Contact Map
1rzuA 1 0.9118 99.9 0.873 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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