Q97VS0 - SULSO - GREMLIN Contacts

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Q97VS0 - Transposon ISC1190

UniProt:	Q97VS0	Sequences: MEAPVAGIDVSKDKLVVYFQGKYYEFQNNKQGFEGVKQVLPKGCKVAIESTGVYHINLAKYLGKEYDVRIINPLVLKKFKNIRGKKSDKNDAKKLAELVISMGSEFTTSEAKELTSQWDFITRSIVRVKNRLRRDLILLGYKDSLSKKNLNEVLRGEDNIVLSEVRFLLDELERLEVRKREIEEELEDLVPKDSLIFTIPGIGRTLGCIILARVGDVKRFGDKKRFVAYCGLDPLVESSGKSVVSRGISRRGDAVLRRAFYLAALTAIKVNPIIKRFYEEHKENLKGKKLITACARKLAVITWAVLYYNKPFDANE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	316 (308)
Sequences:	4574 (3479)
Seq/√Len:	198.2

SULSO - Q97VS0 Q97WC0 Q97Y59 Q97XK2 Q97WZ5 Q97X07 Q97ZN4 Q97X26 Q97UF7 Q97X12 Q97X29 Q97UQ6 Q97YE1 Q97XM7 Q97UU8 Q97Y06 Q97VB2 Q97Z62 Q97XR9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
47_A	99_V	4.318	1.00
282_K	287_G	3.267	1.00
125_I	176_E	3.141	1.00
18_Y	92_A	2.723	1.00
195_L	311_P	2.713	1.00
226_F	299_A	2.643	1.00
167_F	178_R	2.584	1.00
170_D	178_R	2.500	1.00
281_H	284_N	2.478	1.00
163_S	185_E	2.459	1.00
76_L	95_L	2.404	1.00
124_S	127_R	2.262	1.00
47_A	95_L	2.260	1.00
214_V	226_F	2.244	1.00
46_V	66_Y	2.147	1.00
230_C	256_L	2.145	1.00
118_W	122_T	2.101	1.00
210_I	302_T	2.045	1.00
87_S	236_V	2.038	1.00
275_K	279_E	2.015	1.00
125_I	179_K	2.014	1.00
198_T	311_P	2.006	1.00
118_W	183_E	1.978	1.00
221_G	225_R	1.969	1.00
248_I	292_T	1.963	1.00
174_R	178_R	1.961	1.00
296_R	300_V	1.950	1.00
238_S	243_V	1.934	1.00
124_S	131_R	1.921	1.00
14_K	25_E	1.912	1.00
195_L	305_V	1.894	1.00
171_E	174_R	1.861	1.00
126_V	130_N	1.833	1.00
8_I	36_V	1.831	1.00
222_D	225_R	1.818	1.00
6_A	19_F	1.804	1.00
286_K	289_K	1.802	1.00
171_E	178_R	1.797	1.00
199_I	302_T	1.767	1.00
202_I	207_G	1.755	1.00
124_S	171_E	1.739	1.00
8_I	15_L	1.737	1.00
119_D	258_R	1.729	1.00
185_E	188_D	1.724	1.00
45_K	69_R	1.714	1.00
232_L	295_A	1.693	1.00
220_F	229_Y	1.691	1.00
146_S	149_N	1.690	1.00
230_C	299_A	1.682	1.00
310_K	313_D	1.674	1.00
125_I	172_L	1.672	1.00
116_S	213_R	1.669	1.00
196_I	302_T	1.638	1.00
121_I	179_K	1.630	1.00
48_I	68_V	1.602	1.00
305_V	311_P	1.595	1.00
150_L	153_V	1.578	1.00
132_L	172_L	1.567	1.00
280_E	284_N	1.554	1.00
122_T	125_I	1.549	1.00
97_E	101_S	1.534	1.00
8_I	58_L	1.503	1.00
11_S	16_V	1.501	1.00
206_L	259_A	1.494	1.00
209_I	259_A	1.493	1.00
274_I	301_I	1.482	1.00
150_L	157_E	1.480	1.00
304_A	308_Y	1.477	1.00
195_L	198_T	1.466	1.00
17_V	36_V	1.464	1.00
180_R	183_E	1.457	1.00
199_I	305_V	1.454	1.00
154_L	157_E	1.448	1.00
60_K	109_S	1.437	1.00
29_N	32_G	1.437	1.00
262_L	265_L	1.430	1.00
183_E	186_L	1.427	1.00
13_D	241_K	1.425	1.00
48_I	59_A	1.423	1.00
285_L	289_K	1.420	1.00
149_N	152_E	1.398	1.00
274_I	294_C	1.397	1.00
61_Y	64_K	1.395	1.00
132_L	165_V	1.383	1.00
279_E	283_E	1.382	1.00
190_V	197_F	1.382	1.00
197_F	204_R	1.378	1.00
278_Y	294_C	1.363	1.00
268_I	278_Y	1.357	1.00
18_Y	93_K	1.347	1.00
16_V	25_E	1.339	1.00
122_T	179_K	1.324	1.00
85_K	236_V	1.317	1.00
264_A	295_A	1.312	1.00
264_A	298_L	1.309	1.00
278_Y	290_L	1.288	1.00
170_D	174_R	1.285	1.00
277_F	297_K	1.279	1.00
119_D	255_V	1.277	1.00
24_Y	39_V	1.263	1.00
172_L	176_E	1.262	1.00
187_E	204_R	1.258	1.00
128_V	131_R	1.253	1.00
149_N	157_E	1.251	1.00
146_S	157_E	1.251	1.00
118_W	205_T	1.240	1.00
167_F	181_E	1.237	1.00
303_W	307_Y	1.235	1.00
264_A	294_C	1.223	1.00
40_L	46_V	1.221	1.00
124_S	128_V	1.221	1.00
153_V	156_G	1.215	1.00
227_V	233_D	1.214	1.00
188_D	192_K	1.209	1.00
258_R	262_L	1.204	1.00
213_R	253_D	1.198	1.00
27_Q	32_G	1.195	1.00
125_I	129_K	1.192	1.00
47_A	71_I	1.188	1.00
272_P	276_R	1.176	1.00
8_I	17_V	1.174	1.00
118_W	179_K	1.174	1.00
261_Y	295_A	1.172	1.00
227_V	296_R	1.171	1.00
199_I	298_L	1.169	1.00
10_V	15_L	1.166	1.00
11_S	14_K	1.160	1.00
202_I	206_L	1.157	1.00
170_D	177_V	1.156	1.00
120_F	131_R	1.143	1.00
169_L	173_E	1.142	1.00
147_K	151_N	1.118	1.00
16_V	23_Y	1.117	1.00
282_K	290_L	1.117	1.00
123_R	127_R	1.116	1.00
206_L	263_A	1.116	1.00
248_I	257_R	1.115	1.00
117_Q	121_I	1.114	1.00
74_L	78_K	1.113	1.00
146_S	155_R	1.112	1.00
23_Y	93_K	1.108	1.00
143_D	146_S	1.108	1.00
202_I	302_T	1.106	1.00
150_L	156_G	1.104	1.00
196_I	207_G	1.103	1.00
146_S	153_V	1.099	1.00
127_R	130_N	1.097	1.00
71_I	76_L	1.095	1.00
145_L	149_N	1.087	1.00
7_G	96_A	1.083	1.00
33_F	57_N	1.082	1.00
304_A	307_Y	1.078	1.00
146_S	151_N	1.078	1.00
183_E	187_E	1.071	1.00
145_L	153_V	1.069	1.00
33_F	61_Y	1.054	1.00
145_L	150_L	1.052	1.00
153_V	157_E	1.051	1.00
277_F	294_C	1.048	1.00
37_K	61_Y	1.047	1.00
261_Y	292_T	1.046	1.00
115_T	255_V	1.038	1.00
281_H	290_L	1.037	1.00
6_A	46_V	1.033	1.00
263_A	298_L	1.031	1.00
45_K	67_D	1.022	1.00
149_N	154_L	1.017	1.00
46_V	62_L	1.014	1.00
149_N	153_V	1.009	1.00
6_A	17_V	1.002	1.00
146_S	156_G	1.001	1.00
12_K	137_I	0.992	1.00
277_F	293_A	0.992	1.00
17_V	39_V	0.992	1.00
174_R	177_V	0.990	1.00
6_A	40_L	0.990	1.00
301_I	305_V	0.985	1.00
176_E	180_R	0.977	0.99
93_K	97_E	0.973	0.99
26_F	39_V	0.961	0.99
305_V	310_K	0.960	0.99
158_D	161_V	0.958	0.99
151_N	155_R	0.957	0.99
178_R	181_E	0.956	0.99
278_Y	287_G	0.954	0.99
264_A	291_I	0.951	0.99
265_L	287_G	0.949	0.99
151_N	154_L	0.948	0.99
277_F	281_H	0.942	0.99
143_D	147_K	0.941	0.99
147_K	154_L	0.936	0.99
128_V	132_L	0.936	0.99
86_K	91_D	0.935	0.99
114_L	182_I	0.932	0.99
261_Y	265_L	0.930	0.99
167_F	185_E	0.930	0.99
145_L	154_L	0.927	0.99
196_I	306_L	0.925	0.99
105_E	108_T	0.922	0.99
59_A	68_V	0.919	0.99
149_N	156_G	0.919	0.99
146_S	154_L	0.918	0.99
26_F	32_G	0.912	0.99
55_H	70_I	0.910	0.99
147_K	150_L	0.908	0.99
160_I	163_S	0.906	0.99
265_L	268_I	0.906	0.99
185_E	189_L	0.902	0.99
143_D	149_N	0.901	0.99
5_V	99_V	0.900	0.99
217_V	306_L	0.899	0.99
38_Q	41_P	0.899	0.99
250_R	257_R	0.893	0.99
143_D	153_V	0.891	0.99
69_R	99_V	0.884	0.99
59_A	70_I	0.878	0.99
260_F	299_A	0.875	0.99
115_T	186_L	0.873	0.99
145_L	148_K	0.870	0.99
150_L	155_R	0.868	0.99
150_L	154_L	0.865	0.99
117_Q	167_F	0.864	0.99
84_G	228_A	0.864	0.99
146_S	150_L	0.860	0.99
115_T	208_C	0.855	0.99
112_K	213_R	0.852	0.99
145_L	152_E	0.848	0.99
287_G	291_I	0.847	0.99
148_K	151_N	0.844	0.99
202_I	298_L	0.844	0.99
40_L	62_L	0.837	0.98
148_K	152_E	0.833	0.98
281_H	286_K	0.832	0.98
151_N	156_G	0.829	0.98
239_S	243_V	0.826	0.98
214_V	217_V	0.822	0.98
73_P	213_R	0.816	0.98
288_K	291_I	0.813	0.98
128_V	172_L	0.813	0.98
50_S	73_P	0.813	0.98
32_G	35_G	0.813	0.98
261_Y	288_K	0.811	0.98
36_V	40_L	0.809	0.98
5_V	100_I	0.808	0.98
31_Q	35_G	0.805	0.98
146_S	152_E	0.804	0.98
277_F	280_E	0.803	0.98
121_I	182_I	0.802	0.98
122_T	126_V	0.801	0.98
95_L	98_L	0.801	0.98
115_T	209_I	0.799	0.98
15_L	26_F	0.792	0.98
273_I	312_F	0.784	0.98
145_L	157_E	0.778	0.97
144_S	148_K	0.778	0.97
15_L	28_N	0.772	0.97
197_F	207_G	0.771	0.97
274_I	298_L	0.771	0.97
132_L	169_L	0.770	0.97
281_H	285_L	0.766	0.97
292_T	295_A	0.763	0.97
276_R	280_E	0.760	0.97
213_R	255_V	0.760	0.97
129_K	172_L	0.759	0.97
176_E	179_K	0.757	0.97
225_R	228_A	0.757	0.97
265_L	288_K	0.756	0.97
238_S	244_V	0.755	0.97
145_L	155_R	0.755	0.97
128_V	168_L	0.754	0.97
145_L	156_G	0.754	0.97
10_V	48_I	0.753	0.97
177_V	181_E	0.751	0.97
286_K	290_L	0.749	0.97
193_D	211_L	0.748	0.97
167_F	171_E	0.748	0.97
128_V	171_E	0.746	0.97
11_S	15_L	0.746	0.97
302_T	305_V	0.742	0.97
272_P	275_K	0.741	0.97
195_L	309_N	0.739	0.97
16_V	89_K	0.739	0.97
235_L	249_S	0.734	0.96
187_E	191_P	0.730	0.96
17_V	26_F	0.727	0.96
222_D	303_W	0.726	0.96
265_L	295_A	0.724	0.96
45_K	99_V	0.723	0.96
233_D	250_R	0.721	0.96
168_L	171_E	0.721	0.96
144_S	149_N	0.720	0.96
144_S	147_K	0.720	0.96
115_T	212_A	0.718	0.96
84_G	251_R	0.715	0.96
6_A	44_C	0.713	0.96
105_E	109_S	0.712	0.96
143_D	157_E	0.710	0.96
58_L	62_L	0.706	0.96
51_T	54_Y	0.706	0.96
144_S	155_R	0.706	0.96
229_Y	253_D	0.705	0.95
32_G	36_V	0.703	0.95
233_D	249_S	0.701	0.95
152_E	156_G	0.698	0.95
107_T	192_K	0.695	0.95
216_D	219_R	0.693	0.95
147_K	153_V	0.687	0.95
117_Q	182_I	0.686	0.95
50_S	70_I	0.683	0.95
145_L	151_N	0.679	0.94
147_K	157_E	0.678	0.94
119_D	123_R	0.677	0.94
71_I	98_L	0.677	0.94
131_R	168_L	0.676	0.94
122_T	183_E	0.674	0.94
88_D	239_S	0.673	0.94
268_I	282_K	0.673	0.94
37_K	41_P	0.672	0.94
267_A	274_I	0.672	0.94
30_K	34_E	0.672	0.94
72_N	75_V	0.671	0.94
128_V	175_L	0.670	0.94
262_L	288_K	0.669	0.94
79_F	98_L	0.668	0.94
7_G	62_L	0.666	0.94
7_G	92_A	0.665	0.94
43_G	67_D	0.665	0.94
190_V	208_C	0.664	0.94
15_L	58_L	0.660	0.94
236_V	243_V	0.660	0.94
175_L	179_K	0.660	0.94
270_V	275_K	0.658	0.94
37_K	66_Y	0.658	0.94
143_D	151_N	0.654	0.93
18_Y	23_Y	0.652	0.93
289_K	293_A	0.650	0.93
76_L	98_L	0.649	0.93
131_R	134_R	0.649	0.93
210_I	256_L	0.649	0.93
181_E	185_E	0.648	0.93
199_I	202_I	0.645	0.93
79_F	101_S	0.645	0.93
144_S	156_G	0.642	0.93
252_G	257_R	0.641	0.93
85_K	90_N	0.641	0.93
32_G	39_V	0.639	0.93
262_L	266_T	0.638	0.92
34_E	38_Q	0.638	0.92
233_D	236_V	0.637	0.92
43_G	66_Y	0.636	0.92
144_S	157_E	0.635	0.92
98_L	102_M	0.634	0.92
160_I	185_E	0.634	0.92
116_S	255_V	0.633	0.92
175_L	178_R	0.631	0.92
125_I	175_L	0.630	0.92
120_F	124_S	0.629	0.92
143_D	150_L	0.628	0.92
184_E	188_D	0.620	0.91
107_T	110_E	0.619	0.91
143_D	156_G	0.618	0.91
278_Y	282_K	0.618	0.91
281_H	293_A	0.615	0.91
248_I	252_G	0.614	0.91
33_F	39_V	0.613	0.91
209_I	213_R	0.610	0.91
268_I	291_I	0.610	0.91
121_I	175_L	0.609	0.91
271_N	312_F	0.609	0.91
265_L	291_I	0.609	0.91
214_V	230_C	0.607	0.91
233_D	257_R	0.605	0.90
109_S	113_E	0.602	0.90
111_A	186_L	0.602	0.90
171_E	175_L	0.601	0.90
130_N	134_R	0.599	0.90
144_S	152_E	0.596	0.90
259_A	263_A	0.596	0.90
202_I	210_I	0.594	0.90
77_K	82_I	0.592	0.89
53_V	137_I	0.590	0.89
183_E	204_R	0.590	0.89
172_L	175_L	0.590	0.89
143_D	152_E	0.587	0.89
260_F	295_A	0.587	0.89
167_F	170_D	0.585	0.89
265_L	269_K	0.584	0.89
268_I	294_C	0.581	0.89
48_I	70_I	0.580	0.88
119_D	209_I	0.578	0.88
48_I	95_L	0.578	0.88
144_S	154_L	0.577	0.88
166_R	170_D	0.577	0.88
173_E	176_E	0.576	0.88
173_E	177_V	0.576	0.88
116_S	253_D	0.575	0.88
276_R	279_E	0.575	0.88
10_V	54_Y	0.575	0.88
144_S	150_L	0.574	0.88
6_A	62_L	0.574	0.88
11_S	240_G	0.572	0.88
300_V	303_W	0.572	0.88
271_N	275_K	0.571	0.88
223_K	303_W	0.569	0.87
18_Y	96_A	0.566	0.87
31_Q	39_V	0.565	0.87
232_L	296_R	0.565	0.87
126_V	129_K	0.565	0.87
28_N	33_F	0.565	0.87
280_E	283_E	0.565	0.87
163_S	166_R	0.562	0.87
121_I	178_R	0.560	0.87
189_L	192_K	0.559	0.87
258_R	261_Y	0.557	0.86
248_I	293_A	0.557	0.86
159_N	185_E	0.557	0.86
41_P	66_Y	0.555	0.86
97_E	100_I	0.555	0.86
87_S	238_S	0.553	0.86
202_I	263_A	0.553	0.86
34_E	37_K	0.552	0.86
186_L	190_V	0.552	0.86
16_V	239_S	0.551	0.86
74_L	251_R	0.549	0.86
113_E	161_V	0.547	0.85
247_G	289_K	0.547	0.85
183_E	205_T	0.547	0.85
114_L	185_E	0.545	0.85
76_L	94_K	0.545	0.85
266_T	270_V	0.543	0.85
74_L	84_G	0.542	0.85
177_V	180_R	0.542	0.85
205_T	209_I	0.541	0.85
307_Y	310_K	0.538	0.84
237_E	246_R	0.537	0.84
117_Q	131_R	0.535	0.84
90_N	94_K	0.534	0.84
190_V	207_G	0.534	0.84
33_F	58_L	0.534	0.84
217_V	303_W	0.533	0.84
224_K	296_R	0.533	0.84
223_K	300_V	0.532	0.84
157_E	166_R	0.532	0.84
271_N	276_R	0.531	0.84
267_A	298_L	0.531	0.84
161_V	164_E	0.529	0.83
227_V	300_V	0.529	0.83
228_A	233_D	0.528	0.83
62_L	298_L	0.528	0.83
120_F	127_R	0.526	0.83
117_Q	128_V	0.519	0.82
218_K	307_Y	0.518	0.82
301_I	304_A	0.517	0.82
26_F	33_F	0.515	0.82
117_Q	120_F	0.514	0.82
162_L	166_R	0.512	0.81
271_N	301_I	0.511	0.81
249_S	252_G	0.510	0.81
186_L	208_C	0.510	0.81
278_Y	291_I	0.505	0.81
215_G	219_R	0.503	0.80
282_K	285_L	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1hjrA	2	0.3323	91.8	0.934	Contact Map
4ep4A	2	0.3418	91.5	0.935	Contact Map
1nu0A	1	0.307	86.6	0.94	Contact Map
3fhfA	1	0.6171	86.4	0.941	Contact Map
3c1yA	5	0.7532	82.9	0.943	Contact Map
2a1jB	2	0.2437	79.9	0.945	Contact Map
1keaA	2	0.6171	79.4	0.945	Contact Map
1pu6A	1	0.6013	77.2	0.946	Contact Map
1z00A	1	0.2595	75.9	0.947	Contact Map
1vhxA	2	0.3228	75.9	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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