GREMLIN Database
Q97VS0 - Transposon ISC1190
UniProt: Q97VS0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (308)
Sequences: 4574 (3479)
Seq/√Len: 198.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_A99_V4.3181.00
282_K287_G3.2671.00
125_I176_E3.1411.00
18_Y92_A2.7231.00
195_L311_P2.7131.00
226_F299_A2.6431.00
167_F178_R2.5841.00
170_D178_R2.5001.00
281_H284_N2.4781.00
163_S185_E2.4591.00
76_L95_L2.4041.00
124_S127_R2.2621.00
47_A95_L2.2601.00
214_V226_F2.2441.00
46_V66_Y2.1471.00
230_C256_L2.1451.00
118_W122_T2.1011.00
210_I302_T2.0451.00
87_S236_V2.0381.00
275_K279_E2.0151.00
125_I179_K2.0141.00
198_T311_P2.0061.00
118_W183_E1.9781.00
221_G225_R1.9691.00
248_I292_T1.9631.00
174_R178_R1.9611.00
296_R300_V1.9501.00
238_S243_V1.9341.00
124_S131_R1.9211.00
14_K25_E1.9121.00
195_L305_V1.8941.00
171_E174_R1.8611.00
126_V130_N1.8331.00
8_I36_V1.8311.00
222_D225_R1.8181.00
6_A19_F1.8041.00
286_K289_K1.8021.00
171_E178_R1.7971.00
199_I302_T1.7671.00
202_I207_G1.7551.00
124_S171_E1.7391.00
8_I15_L1.7371.00
119_D258_R1.7291.00
185_E188_D1.7241.00
45_K69_R1.7141.00
232_L295_A1.6931.00
220_F229_Y1.6911.00
146_S149_N1.6901.00
230_C299_A1.6821.00
310_K313_D1.6741.00
125_I172_L1.6721.00
116_S213_R1.6691.00
196_I302_T1.6381.00
121_I179_K1.6301.00
48_I68_V1.6021.00
305_V311_P1.5951.00
150_L153_V1.5781.00
132_L172_L1.5671.00
280_E284_N1.5541.00
122_T125_I1.5491.00
97_E101_S1.5341.00
8_I58_L1.5031.00
11_S16_V1.5011.00
206_L259_A1.4941.00
209_I259_A1.4931.00
274_I301_I1.4821.00
150_L157_E1.4801.00
304_A308_Y1.4771.00
195_L198_T1.4661.00
17_V36_V1.4641.00
180_R183_E1.4571.00
199_I305_V1.4541.00
154_L157_E1.4481.00
60_K109_S1.4371.00
29_N32_G1.4371.00
262_L265_L1.4301.00
183_E186_L1.4271.00
13_D241_K1.4251.00
48_I59_A1.4231.00
285_L289_K1.4201.00
149_N152_E1.3981.00
274_I294_C1.3971.00
61_Y64_K1.3951.00
132_L165_V1.3831.00
279_E283_E1.3821.00
190_V197_F1.3821.00
197_F204_R1.3781.00
278_Y294_C1.3631.00
268_I278_Y1.3571.00
18_Y93_K1.3471.00
16_V25_E1.3391.00
122_T179_K1.3241.00
85_K236_V1.3171.00
264_A295_A1.3121.00
264_A298_L1.3091.00
278_Y290_L1.2881.00
170_D174_R1.2851.00
277_F297_K1.2791.00
119_D255_V1.2771.00
24_Y39_V1.2631.00
172_L176_E1.2621.00
187_E204_R1.2581.00
128_V131_R1.2531.00
149_N157_E1.2511.00
146_S157_E1.2511.00
118_W205_T1.2401.00
167_F181_E1.2371.00
303_W307_Y1.2351.00
264_A294_C1.2231.00
40_L46_V1.2211.00
124_S128_V1.2211.00
153_V156_G1.2151.00
227_V233_D1.2141.00
188_D192_K1.2091.00
258_R262_L1.2041.00
213_R253_D1.1981.00
27_Q32_G1.1951.00
125_I129_K1.1921.00
47_A71_I1.1881.00
272_P276_R1.1761.00
8_I17_V1.1741.00
118_W179_K1.1741.00
261_Y295_A1.1721.00
227_V296_R1.1711.00
199_I298_L1.1691.00
10_V15_L1.1661.00
11_S14_K1.1601.00
202_I206_L1.1571.00
170_D177_V1.1561.00
120_F131_R1.1431.00
169_L173_E1.1421.00
147_K151_N1.1181.00
16_V23_Y1.1171.00
282_K290_L1.1171.00
123_R127_R1.1161.00
206_L263_A1.1161.00
248_I257_R1.1151.00
117_Q121_I1.1141.00
74_L78_K1.1131.00
146_S155_R1.1121.00
23_Y93_K1.1081.00
143_D146_S1.1081.00
202_I302_T1.1061.00
150_L156_G1.1041.00
196_I207_G1.1031.00
146_S153_V1.0991.00
127_R130_N1.0971.00
71_I76_L1.0951.00
145_L149_N1.0871.00
7_G96_A1.0831.00
33_F57_N1.0821.00
304_A307_Y1.0781.00
146_S151_N1.0781.00
183_E187_E1.0711.00
145_L153_V1.0691.00
33_F61_Y1.0541.00
145_L150_L1.0521.00
153_V157_E1.0511.00
277_F294_C1.0481.00
37_K61_Y1.0471.00
261_Y292_T1.0461.00
115_T255_V1.0381.00
281_H290_L1.0371.00
6_A46_V1.0331.00
263_A298_L1.0311.00
45_K67_D1.0221.00
149_N154_L1.0171.00
46_V62_L1.0141.00
149_N153_V1.0091.00
6_A17_V1.0021.00
146_S156_G1.0011.00
12_K137_I0.9921.00
277_F293_A0.9921.00
17_V39_V0.9921.00
174_R177_V0.9901.00
6_A40_L0.9901.00
301_I305_V0.9851.00
176_E180_R0.9770.99
93_K97_E0.9730.99
26_F39_V0.9610.99
305_V310_K0.9600.99
158_D161_V0.9580.99
151_N155_R0.9570.99
178_R181_E0.9560.99
278_Y287_G0.9540.99
264_A291_I0.9510.99
265_L287_G0.9490.99
151_N154_L0.9480.99
277_F281_H0.9420.99
143_D147_K0.9410.99
147_K154_L0.9360.99
128_V132_L0.9360.99
86_K91_D0.9350.99
114_L182_I0.9320.99
261_Y265_L0.9300.99
167_F185_E0.9300.99
145_L154_L0.9270.99
196_I306_L0.9250.99
105_E108_T0.9220.99
59_A68_V0.9190.99
149_N156_G0.9190.99
146_S154_L0.9180.99
26_F32_G0.9120.99
55_H70_I0.9100.99
147_K150_L0.9080.99
160_I163_S0.9060.99
265_L268_I0.9060.99
185_E189_L0.9020.99
143_D149_N0.9010.99
5_V99_V0.9000.99
217_V306_L0.8990.99
38_Q41_P0.8990.99
250_R257_R0.8930.99
143_D153_V0.8910.99
69_R99_V0.8840.99
59_A70_I0.8780.99
260_F299_A0.8750.99
115_T186_L0.8730.99
145_L148_K0.8700.99
150_L155_R0.8680.99
150_L154_L0.8650.99
117_Q167_F0.8640.99
84_G228_A0.8640.99
146_S150_L0.8600.99
115_T208_C0.8550.99
112_K213_R0.8520.99
145_L152_E0.8480.99
287_G291_I0.8470.99
148_K151_N0.8440.99
202_I298_L0.8440.99
40_L62_L0.8370.98
148_K152_E0.8330.98
281_H286_K0.8320.98
151_N156_G0.8290.98
239_S243_V0.8260.98
214_V217_V0.8220.98
73_P213_R0.8160.98
288_K291_I0.8130.98
128_V172_L0.8130.98
50_S73_P0.8130.98
32_G35_G0.8130.98
261_Y288_K0.8110.98
36_V40_L0.8090.98
5_V100_I0.8080.98
31_Q35_G0.8050.98
146_S152_E0.8040.98
277_F280_E0.8030.98
121_I182_I0.8020.98
122_T126_V0.8010.98
95_L98_L0.8010.98
115_T209_I0.7990.98
15_L26_F0.7920.98
273_I312_F0.7840.98
145_L157_E0.7780.97
144_S148_K0.7780.97
15_L28_N0.7720.97
197_F207_G0.7710.97
274_I298_L0.7710.97
132_L169_L0.7700.97
281_H285_L0.7660.97
292_T295_A0.7630.97
276_R280_E0.7600.97
213_R255_V0.7600.97
129_K172_L0.7590.97
176_E179_K0.7570.97
225_R228_A0.7570.97
265_L288_K0.7560.97
238_S244_V0.7550.97
145_L155_R0.7550.97
128_V168_L0.7540.97
145_L156_G0.7540.97
10_V48_I0.7530.97
177_V181_E0.7510.97
286_K290_L0.7490.97
193_D211_L0.7480.97
167_F171_E0.7480.97
128_V171_E0.7460.97
11_S15_L0.7460.97
302_T305_V0.7420.97
272_P275_K0.7410.97
195_L309_N0.7390.97
16_V89_K0.7390.97
235_L249_S0.7340.96
187_E191_P0.7300.96
17_V26_F0.7270.96
222_D303_W0.7260.96
265_L295_A0.7240.96
45_K99_V0.7230.96
233_D250_R0.7210.96
168_L171_E0.7210.96
144_S149_N0.7200.96
144_S147_K0.7200.96
115_T212_A0.7180.96
84_G251_R0.7150.96
6_A44_C0.7130.96
105_E109_S0.7120.96
143_D157_E0.7100.96
58_L62_L0.7060.96
51_T54_Y0.7060.96
144_S155_R0.7060.96
229_Y253_D0.7050.95
32_G36_V0.7030.95
233_D249_S0.7010.95
152_E156_G0.6980.95
107_T192_K0.6950.95
216_D219_R0.6930.95
147_K153_V0.6870.95
117_Q182_I0.6860.95
50_S70_I0.6830.95
145_L151_N0.6790.94
147_K157_E0.6780.94
119_D123_R0.6770.94
71_I98_L0.6770.94
131_R168_L0.6760.94
122_T183_E0.6740.94
88_D239_S0.6730.94
268_I282_K0.6730.94
37_K41_P0.6720.94
267_A274_I0.6720.94
30_K34_E0.6720.94
72_N75_V0.6710.94
128_V175_L0.6700.94
262_L288_K0.6690.94
79_F98_L0.6680.94
7_G62_L0.6660.94
7_G92_A0.6650.94
43_G67_D0.6650.94
190_V208_C0.6640.94
15_L58_L0.6600.94
236_V243_V0.6600.94
175_L179_K0.6600.94
270_V275_K0.6580.94
37_K66_Y0.6580.94
143_D151_N0.6540.93
18_Y23_Y0.6520.93
289_K293_A0.6500.93
76_L98_L0.6490.93
131_R134_R0.6490.93
210_I256_L0.6490.93
181_E185_E0.6480.93
199_I202_I0.6450.93
79_F101_S0.6450.93
144_S156_G0.6420.93
252_G257_R0.6410.93
85_K90_N0.6410.93
32_G39_V0.6390.93
262_L266_T0.6380.92
34_E38_Q0.6380.92
233_D236_V0.6370.92
43_G66_Y0.6360.92
144_S157_E0.6350.92
98_L102_M0.6340.92
160_I185_E0.6340.92
116_S255_V0.6330.92
175_L178_R0.6310.92
125_I175_L0.6300.92
120_F124_S0.6290.92
143_D150_L0.6280.92
184_E188_D0.6200.91
107_T110_E0.6190.91
143_D156_G0.6180.91
278_Y282_K0.6180.91
281_H293_A0.6150.91
248_I252_G0.6140.91
33_F39_V0.6130.91
209_I213_R0.6100.91
268_I291_I0.6100.91
121_I175_L0.6090.91
271_N312_F0.6090.91
265_L291_I0.6090.91
214_V230_C0.6070.91
233_D257_R0.6050.90
109_S113_E0.6020.90
111_A186_L0.6020.90
171_E175_L0.6010.90
130_N134_R0.5990.90
144_S152_E0.5960.90
259_A263_A0.5960.90
202_I210_I0.5940.90
77_K82_I0.5920.89
53_V137_I0.5900.89
183_E204_R0.5900.89
172_L175_L0.5900.89
143_D152_E0.5870.89
260_F295_A0.5870.89
167_F170_D0.5850.89
265_L269_K0.5840.89
268_I294_C0.5810.89
48_I70_I0.5800.88
119_D209_I0.5780.88
48_I95_L0.5780.88
144_S154_L0.5770.88
166_R170_D0.5770.88
173_E176_E0.5760.88
173_E177_V0.5760.88
116_S253_D0.5750.88
276_R279_E0.5750.88
10_V54_Y0.5750.88
144_S150_L0.5740.88
6_A62_L0.5740.88
11_S240_G0.5720.88
300_V303_W0.5720.88
271_N275_K0.5710.88
223_K303_W0.5690.87
18_Y96_A0.5660.87
31_Q39_V0.5650.87
232_L296_R0.5650.87
126_V129_K0.5650.87
28_N33_F0.5650.87
280_E283_E0.5650.87
163_S166_R0.5620.87
121_I178_R0.5600.87
189_L192_K0.5590.87
258_R261_Y0.5570.86
248_I293_A0.5570.86
159_N185_E0.5570.86
41_P66_Y0.5550.86
97_E100_I0.5550.86
87_S238_S0.5530.86
202_I263_A0.5530.86
34_E37_K0.5520.86
186_L190_V0.5520.86
16_V239_S0.5510.86
74_L251_R0.5490.86
113_E161_V0.5470.85
247_G289_K0.5470.85
183_E205_T0.5470.85
114_L185_E0.5450.85
76_L94_K0.5450.85
266_T270_V0.5430.85
74_L84_G0.5420.85
177_V180_R0.5420.85
205_T209_I0.5410.85
307_Y310_K0.5380.84
237_E246_R0.5370.84
117_Q131_R0.5350.84
90_N94_K0.5340.84
190_V207_G0.5340.84
33_F58_L0.5340.84
217_V303_W0.5330.84
224_K296_R0.5330.84
223_K300_V0.5320.84
157_E166_R0.5320.84
271_N276_R0.5310.84
267_A298_L0.5310.84
161_V164_E0.5290.83
227_V300_V0.5290.83
228_A233_D0.5280.83
62_L298_L0.5280.83
120_F127_R0.5260.83
117_Q128_V0.5190.82
218_K307_Y0.5180.82
301_I304_A0.5170.82
26_F33_F0.5150.82
117_Q120_F0.5140.82
162_L166_R0.5120.81
271_N301_I0.5110.81
249_S252_G0.5100.81
186_L208_C0.5100.81
278_Y291_I0.5050.81
215_G219_R0.5030.80
282_K285_L0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hjrA 2 0.3323 91.8 0.934 Contact Map
4ep4A 2 0.3418 91.5 0.935 Contact Map
1nu0A 1 0.307 86.6 0.94 Contact Map
3fhfA 1 0.6171 86.4 0.941 Contact Map
3c1yA 5 0.7532 82.9 0.943 Contact Map
2a1jB 2 0.2437 79.9 0.945 Contact Map
1keaA 2 0.6171 79.4 0.945 Contact Map
1pu6A 1 0.6013 77.2 0.946 Contact Map
1z00A 1 0.2595 75.9 0.947 Contact Map
1vhxA 2 0.3228 75.9 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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