GREMLIN Database
Q97VR4 - Amino acid transporter, putative
UniProt: Q97VR4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 505 (425)
Sequences: 24942 (16349)
Seq/√Len: 793.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_I379_F4.4311.00
361_V373_Y4.3111.00
419_R423_S3.5361.00
63_F279_L3.1841.00
364_R373_Y3.1481.00
23_S262_K2.9471.00
266_G269_Y2.9121.00
87_Y355_D2.8301.00
429_M432_S2.8051.00
103_G352_F2.7021.00
366_N372_A2.6561.00
261_I267_I2.6521.00
353_S363_S2.6481.00
263_N266_G2.5821.00
201_L288_L2.5501.00
162_A383_L2.5381.00
28_T273_L2.4781.00
75_Y421_A2.4691.00
24_L273_L2.4031.00
321_A325_F2.4021.00
259_S354_F2.3881.00
361_V364_R2.3751.00
199_L203_L2.3141.00
411_V442_F2.2441.00
91_S99_G2.2401.00
376_L380_V2.2291.00
260_E347_R2.1871.00
27_V261_I2.1641.00
170_L174_L2.1581.00
177_R181_T2.1401.00
24_L28_T2.1401.00
169_I375_H2.1291.00
439_F443_M2.1251.00
24_L267_I2.1101.00
350_F354_F2.0971.00
166_L383_L2.0641.00
173_I372_A2.0471.00
162_A386_L2.0351.00
18_L365_L2.0291.00
94_L419_R2.0241.00
161_A386_L1.9791.00
107_A378_D1.9761.00
46_S55_L1.9681.00
91_S96_G1.9671.00
294_G297_F1.9231.00
269_Y273_L1.9141.00
362_F377_L1.9071.00
430_L435_L1.8881.00
356_R360_E1.8861.00
272_I276_L1.8751.00
23_S26_D1.8721.00
188_M192_L1.8661.00
64_L68_P1.8551.00
479_I483_S1.8341.00
306_T309_F1.8121.00
172_N339_A1.8041.00
72_L414_S1.8031.00
414_S441_G1.8011.00
94_L415_I1.7881.00
26_D184_S1.7831.00
471_T475_G1.7451.00
90_L102_M1.7271.00
229_P232_S1.7221.00
435_L439_F1.7081.00
473_L477_G1.6951.00
166_L379_F1.6891.00
192_L196_V1.6831.00
431_I435_L1.6791.00
28_T277_L1.6771.00
433_A437_I1.6711.00
366_N370_S1.6641.00
31_N274_G1.6551.00
435_L438_G1.6391.00
419_R422_L1.6361.00
102_M412_L1.6281.00
118_A338_M1.6231.00
305_G308_N1.6191.00
125_I160_L1.6161.00
104_V477_G1.6121.00
263_N267_I1.6101.00
173_I376_L1.6021.00
54_V236_T1.5961.00
434_L438_G1.5931.00
22_V26_D1.5921.00
165_F382_T1.5861.00
58_A239_M1.5721.00
309_F314_I1.5611.00
276_L280_I1.5601.00
118_A165_F1.5161.00
95_N98_L1.5141.00
443_M447_A1.4971.00
447_A451_P1.4921.00
257_V343_V1.4921.00
263_N269_Y1.4761.00
424_E427_L1.4701.00
373_Y377_L1.4651.00
191_L195_L1.4421.00
311_T315_A1.4391.00
349_V374_A1.4371.00
436_S440_L1.4261.00
165_F379_F1.4261.00
62_T244_A1.4241.00
432_S435_L1.4211.00
193_G329_S1.4191.00
431_I434_L1.4141.00
70_V275_S1.4051.00
114_F382_T1.4021.00
429_M435_L1.3891.00
19_T369_G1.3791.00
345_F378_D1.3731.00
445_Y448_F1.3721.00
18_L350_F1.3671.00
121_S164_A1.3631.00
360_E364_R1.3581.00
350_F365_L1.3581.00
83_T259_S1.3511.00
202_T288_L1.3481.00
346_A375_H1.3451.00
360_E363_S1.3441.00
415_I419_R1.3351.00
26_D180_Y1.3331.00
309_F312_V1.3301.00
121_S331_I1.3231.00
162_A166_L1.3221.00
169_I376_L1.3221.00
94_L98_L1.3151.00
364_R372_A1.3081.00
478_V482_V1.3081.00
308_N312_V1.3051.00
436_S439_F1.3031.00
24_L269_Y1.3001.00
448_F452_Y1.2941.00
264_K268_R1.2941.00
425_R428_G1.2861.00
305_G311_T1.2761.00
477_G480_T1.2741.00
22_V27_V1.2711.00
398_A401_S1.2691.00
56_W287_L1.2681.00
69_L414_S1.2641.00
447_A450_N1.2631.00
90_L412_L1.2601.00
324_W328_I1.2601.00
437_I441_G1.2571.00
349_V358_F1.2551.00
472_S476_L1.2551.00
22_V180_Y1.2551.00
41_I120_F1.2531.00
70_V271_L1.2531.00
80_I92_R1.2491.00
71_F272_I1.2471.00
97_P484_S1.2471.00
482_V486_Y1.2411.00
54_V229_P1.2401.00
464_W467_I1.2391.00
297_F316_L1.2371.00
198_I284_V1.2361.00
468_A472_S1.2361.00
280_I284_V1.2361.00
422_L425_R1.2331.00
168_I338_M1.2271.00
450_N453_F1.2201.00
82_R88_I1.2181.00
93_K416_A1.2141.00
447_A452_Y1.2131.00
312_V315_A1.2121.00
205_I291_V1.2091.00
441_G445_Y1.2081.00
117_S337_V1.2081.00
232_S235_S1.2021.00
464_W468_A1.1991.00
429_M434_L1.1941.00
88_I92_R1.1921.00
480_T483_S1.1911.00
32_V277_L1.1881.00
171_I182_L1.1811.00
430_L433_A1.1751.00
65_F444_G1.1751.00
306_T312_V1.1731.00
483_S487_Y1.1721.00
438_G441_G1.1721.00
47_P55_L1.1541.00
183_T339_A1.1531.00
27_V270_N1.1521.00
433_A436_S1.1471.00
429_M433_A1.1381.00
90_L98_L1.1371.00
107_A349_V1.1351.00
73_Y86_D1.1261.00
31_N254_G1.1241.00
430_L434_L1.1231.00
182_L186_L1.1231.00
75_Y78_S1.1211.00
442_F446_E1.1201.00
100_A104_V1.1201.00
465_P468_A1.1181.00
449_T452_Y1.1161.00
446_E450_N1.1131.00
421_A425_R1.1071.00
202_T206_S1.1061.00
82_R92_R1.1041.00
308_N311_T1.1021.00
92_R424_E1.0971.00
365_L369_G1.0941.00
25_L29_M1.0911.00
438_G442_F1.0861.00
87_Y351_A1.0851.00
435_L452_Y1.0821.00
201_L292_A1.0771.00
159_G163_V1.0751.00
122_V160_L1.0741.00
483_S486_Y1.0731.00
195_L199_L1.0721.00
445_Y449_T1.0681.00
373_Y376_L1.0681.00
441_G452_Y1.0651.00
295_Y298_N1.0631.00
77_I89_W1.0631.00
163_V167_I1.0611.00
196_V200_V1.0601.00
307_Y311_T1.0581.00
380_V384_V1.0581.00
354_F363_S1.0571.00
311_T314_I1.0571.00
35_M278_T1.0551.00
197_A201_L1.0511.00
305_G309_F1.0511.00
212_I215_F1.0481.00
169_I173_I1.0461.00
472_S475_G1.0391.00
438_G452_Y1.0351.00
210_T213_Q1.0301.00
211_V214_P1.0271.00
79_R427_L1.0261.00
475_G479_I1.0261.00
314_I318_R1.0141.00
448_F451_P1.0101.00
484_S487_Y1.0021.00
249_I406_A1.0011.00
449_T453_F1.0011.00
181_T185_A0.9991.00
229_P236_T0.9961.00
262_K267_I0.9891.00
465_P469_Y0.9881.00
122_V161_A0.9871.00
186_L336_F0.9801.00
190_S333_W0.9791.00
176_P343_V0.9791.00
173_I370_S0.9771.00
173_I366_N0.9701.00
60_L283_T0.9671.00
431_I438_G0.9661.00
212_I216_I0.9611.00
21_N262_K0.9571.00
116_L246_F0.9511.00
63_F248_Y0.9471.00
430_L452_Y0.9421.00
125_I331_I0.9391.00
441_G444_G0.9371.00
30_L257_V0.9291.00
480_T484_S0.9261.00
97_P101_I0.9241.00
470_I474_I0.9231.00
191_L281_F0.9171.00
166_L170_L0.9171.00
168_I339_A0.9101.00
434_L437_I0.9091.00
252_Y256_A0.9091.00
125_I129_L0.9041.00
287_L291_V0.9021.00
56_W290_D0.8971.00
411_V415_I0.8951.00
433_A452_Y0.8901.00
438_G448_F0.8861.00
167_I335_F0.8841.00
464_W477_G0.8841.00
21_N177_R0.8831.00
364_R367_K0.8801.00
342_V379_F0.8791.00
314_I319_N0.8781.00
320_Y324_W0.8781.00
18_L347_R0.8751.00
467_I471_T0.8721.00
433_A438_G0.8681.00
91_S355_D0.8671.00
468_A471_T0.8671.00
97_P478_V0.8651.00
104_V358_F0.8631.00
210_T214_P0.8621.00
469_Y472_S0.8561.00
29_M184_S0.8531.00
233_L236_T0.8501.00
53_A57_I0.8491.00
441_G450_N0.8461.00
432_S436_S0.8451.00
32_V278_T0.8451.00
430_L439_F0.8381.00
437_I451_P0.8371.00
362_F373_Y0.8371.00
467_I470_I0.8371.00
26_D181_T0.8361.00
18_L260_E0.8331.00
25_L184_S0.8331.00
445_Y452_Y0.8321.00
203_L206_S0.8321.00
379_F383_L0.8321.00
439_F442_F0.8311.00
198_I288_L0.8271.00
314_I317_S0.8231.00
238_Y242_Y0.8231.00
130_L133_G0.8221.00
372_A376_L0.8211.00
121_S335_F0.8201.00
466_G470_I0.8191.00
273_L277_L0.8141.00
165_F386_L0.8131.00
206_S214_P0.8131.00
122_V157_A0.8101.00
253_A344_V0.8091.00
79_R425_R0.8091.00
68_P72_L0.8071.00
57_I61_L0.8071.00
67_L71_F0.8061.00
268_R271_L0.8041.00
67_L272_I0.8031.00
84_G88_I0.8021.00
358_F362_F0.8001.00
417_G421_A0.8001.00
237_F447_A0.8001.00
477_G481_F0.7991.00
226_Y232_S0.7951.00
418_I422_L0.7921.00
434_L441_G0.7911.00
24_L270_N0.7881.00
170_L173_I0.7871.00
98_L412_L0.7861.00
434_L439_F0.7821.00
415_I442_F0.7801.00
279_L283_T0.7791.00
198_I202_T0.7781.00
160_L163_V0.7771.00
121_S334_E0.7761.00
60_L64_L0.7751.00
438_G445_Y0.7751.00
318_R322_L0.7661.00
437_I440_L0.7651.00
263_N268_R0.7641.00
285_P289_M0.7631.00
84_G87_Y0.7621.00
68_P440_L0.7601.00
434_L452_Y0.7591.00
397_E400_Y0.7591.00
168_I342_V0.7541.00
400_Y403_T0.7541.00
430_L437_I0.7501.00
434_L449_T0.7441.00
39_L285_P0.7431.00
174_L178_W0.7421.00
73_Y413_V0.7391.00
441_G448_F0.7381.00
437_I445_Y0.7361.00
90_L416_A0.7361.00
64_L440_L0.7341.00
446_E449_T0.7331.00
404_P470_I0.7321.00
444_G451_P0.7311.00
95_N485_Y0.7301.00
444_G453_F0.7291.00
440_L444_G0.7251.00
181_T184_S0.7221.00
229_P233_L0.7211.00
416_A420_Q0.7191.00
437_I452_Y0.7191.00
57_I236_T0.7171.00
441_G453_F0.7141.00
28_T270_N0.7141.00
438_G451_P0.7141.00
72_L438_G0.7131.00
76_F89_W0.7071.00
172_N375_H0.7051.00
431_I437_I0.7041.00
33_A187_G0.7041.00
180_Y184_S0.7011.00
205_I288_L0.7011.00
367_K372_A0.6971.00
21_N176_P0.6961.00
203_L207_D0.6961.00
180_Y339_A0.6961.00
83_T350_F0.6931.00
307_Y310_W0.6931.00
206_S210_T0.6931.00
482_V485_Y0.6921.00
57_I60_L0.6911.00
349_V377_L0.6911.00
312_V316_L0.6881.00
122_V125_I0.6861.00
198_I285_P0.6861.00
284_V288_L0.6821.00
105_A409_Y0.6821.00
449_T467_I0.6811.00
366_N369_G0.6791.00
106_L110_M0.6791.00
25_L181_T0.6781.00
264_K267_I0.6781.00
321_A324_W0.6771.00
440_L451_P0.6771.00
36_G282_I0.6761.00
226_Y229_P0.6731.00
471_T477_G0.6731.00
129_L132_I0.6731.00
249_I410_L0.6711.00
422_L426_N0.6671.00
172_N343_V0.6671.00
346_A374_A0.6671.00
255_P271_L0.6671.00
28_T31_N0.6651.00
173_I375_H0.6641.00
435_L441_G0.6641.00
202_T284_V0.6621.00
474_I478_V0.6621.00
209_H212_I0.6591.00
124_A330_L0.6581.00
237_F241_P0.6571.00
433_A439_F0.6561.00
87_Y91_S0.6561.00
76_F417_G0.6531.00
43_I286_F0.6521.00
347_R350_F0.6521.00
213_Q216_I0.6501.00
361_V377_L0.6491.00
306_T310_W0.6491.00
288_L291_V0.6481.00
211_V215_F0.6471.00
430_L441_G0.6461.00
473_L478_V0.6461.00
430_L438_G0.6461.00
380_V383_L0.6441.00
36_G39_L0.6431.00
115_A385_F0.6411.00
176_P257_V0.6391.00
476_L480_T0.6371.00
448_F453_F0.6371.00
66_T251_L0.6361.00
36_G40_A0.6361.00
313_A317_S0.6351.00
111_P381_V0.6331.00
440_L443_M0.6321.00
342_V346_A0.6321.00
87_Y99_G0.6311.00
111_P378_D0.6311.00
444_G447_A0.6291.00
109_N406_A0.6291.00
233_L237_F0.6271.00
265_S269_Y0.6261.00
158_Y162_A0.6251.00
200_V319_N0.6231.00
55_L286_F0.6231.00
70_V251_L0.6231.00
47_P51_E0.6221.00
94_L416_A0.6221.00
447_A453_F0.6221.00
313_A316_L0.6221.00
479_I482_V0.6221.00
441_G449_T0.6191.00
442_F450_N0.6191.00
466_G469_Y0.6191.00
32_V187_G0.6181.00
438_G453_F0.6171.00
113_F403_T0.6151.00
473_L476_L0.6151.00
162_A387_A0.6151.00
277_L281_F0.6151.00
444_G450_N0.6131.00
87_Y103_G0.6131.00
466_G477_G0.6131.00
362_F374_A0.6121.00
125_I164_A0.6121.00
259_S350_F0.6111.00
405_L409_Y0.6111.00
438_G444_G0.6101.00
328_I332_A0.6071.00
438_G450_N0.6061.00
211_V216_I0.6061.00
312_V318_R0.6051.00
164_A338_M0.6051.00
236_T240_I0.6041.00
473_L480_T0.6031.00
59_S247_A0.6021.00
77_I255_P0.6011.00
444_G448_F0.6011.00
189_F329_S0.6011.00
235_S238_Y0.6001.00
308_N314_I0.5991.00
420_Q424_E0.5981.00
418_I439_F0.5941.00
127_S327_G0.5941.00
209_H213_Q0.5941.00
75_Y79_R0.5941.00
86_D252_Y0.5931.00
110_M341_G0.5911.00
476_L479_I0.5891.00
166_L169_I0.5891.00
256_A344_V0.5881.00
371_P374_A0.5861.00
431_I452_Y0.5851.00
116_L400_Y0.5851.00
21_N25_L0.5811.00
307_Y312_V0.5811.00
36_G41_I0.5801.00
113_F116_L0.5801.00
282_I286_F0.5801.00
470_I477_G0.5801.00
423_S427_L0.5791.00
56_W283_T0.5781.00
442_F451_P0.5781.00
312_V319_N0.5771.00
353_S362_F0.5771.00
439_F449_T0.5761.00
197_A313_A0.5761.00
439_F451_P0.5751.00
434_L453_F0.5751.00
273_L276_L0.5731.00
431_I449_T0.5721.00
93_K420_Q0.5721.00
420_Q425_R0.5721.00
249_I252_Y0.5721.00
178_W181_T0.5711.00
56_W59_S0.5711.00
230_T233_L0.5711.00
76_F93_K0.5681.00
25_L28_T0.5671.00
411_V446_E0.5651.00
384_V387_A0.5651.00
200_V204_N0.5651.00
118_A122_V0.5641.00
434_L451_P0.5631.00
56_W60_L0.5621.00
52_G290_D0.5621.00
345_F349_V0.5611.00
184_S188_M0.5601.00
228_G232_S0.5601.00
470_I475_G0.5591.00
260_E371_P0.5581.00
183_T336_F0.5581.00
128_V328_I0.5581.00
168_I335_F0.5581.00
189_F193_G0.5571.00
164_A335_F0.5551.00
86_D256_A0.5541.00
31_N34_N0.5521.00
132_I135_L0.5501.00
277_L280_I0.5501.00
422_L435_L0.5491.00
368_Q372_A0.5481.00
227_K230_T0.5481.00
74_T78_S0.5461.00
429_M445_Y0.5461.00
443_M446_E0.5451.00
319_N322_L0.5441.00
105_A109_N0.5431.00
396_Y400_Y0.5431.00
308_N318_R0.5421.00
164_A168_I0.5421.00
39_L43_I0.5421.00
117_S338_M0.5411.00
399_L403_T0.5401.00
439_F450_N0.5381.00
174_L368_Q0.5361.00
117_S120_F0.5361.00
315_A323_E0.5361.00
465_P470_I0.5361.00
435_L451_P0.5351.00
27_V257_V0.5351.00
429_M438_G0.5331.00
212_I291_V0.5321.00
46_S50_V0.5321.00
421_A428_G0.5321.00
43_I289_M0.5311.00
85_G255_P0.5301.00
37_A246_F0.5301.00
178_W182_L0.5301.00
333_W336_F0.5291.00
294_G316_L0.5281.00
201_L205_I0.5271.00
165_F383_L0.5271.00
179_G343_V0.5271.00
480_T486_Y0.5261.00
175_R178_W0.5251.00
17_G20_K0.5251.00
388_V391_I0.5241.00
117_S334_E0.5241.00
158_Y386_L0.5231.00
166_L376_L0.5221.00
438_G449_T0.5221.00
22_V176_P0.5221.00
113_F249_I0.5201.00
434_L448_F0.5201.00
464_W471_T0.5191.00
432_S451_P0.5181.00
464_W473_L0.5181.00
431_I439_F0.5171.00
169_I342_V0.5171.00
93_K419_R0.5171.00
347_R371_P0.5171.00
61_L240_I0.5161.00
338_M341_G0.5151.00
231_F234_S0.5151.00
70_V74_T0.5151.00
236_T239_M0.5151.00
308_N316_L0.5131.00
18_L83_T0.5131.00
480_T487_Y0.5131.00
31_N270_N0.5121.00
163_V166_L0.5121.00
435_L450_N0.5121.00
42_F45_I0.5111.00
387_A390_I0.5101.00
310_W314_I0.5091.00
200_V317_S0.5091.00
431_I441_G0.5091.00
187_G190_S0.5081.00
102_M409_Y0.5081.00
434_L450_N0.5081.00
468_A473_L0.5071.00
470_I480_T0.5071.00
342_V375_H0.5071.00
120_F124_A0.5061.00
277_L284_V0.5051.00
205_I292_A0.5041.00
183_T190_S0.5041.00
40_A190_S0.5031.00
398_A402_Y0.5031.00
311_T318_R0.5031.00
404_P449_T0.5031.00
99_G103_G0.5021.00
325_F329_S0.5011.00
45_I48_Y0.5001.00
212_I290_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8277 100 0.366 Contact Map
3giaA 1 0.8396 100 0.406 Contact Map
4djkA 2 0.8475 100 0.418 Contact Map
3dh4A 3 0.8693 99 0.86 Contact Map
2jlnA 1 0.8337 98.9 0.865 Contact Map
2xq2A 2 0.8752 98.8 0.869 Contact Map
4xp4A 1 0.9129 98 0.897 Contact Map
4wgvA 2 0.7347 97.6 0.904 Contact Map
2a65A 2 0.8871 97.4 0.909 Contact Map
4us3A 1 0.8158 96.3 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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