Q97VR0 - SULSO - GREMLIN Contacts

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Q97VR0 - Uncharacterized protein

UniProt:	Q97VR0	Sequences: MSEKEFIMASAESWLENEISTDTFTMNSLRPFYLYLRNELKLLLGVNFIEERNKLIKNDPVNYMRLLFDDAGIDGFVIDTGFGKKEMEIPAKLKLLFRIESIINDDIFQMSFDKALEYFEETLRRKITKEGYAGFKSIIAYRTGLKVNCNIEEARRDFHSNEKDWFGKVAKGFRDYLLCETLRIAKELRVPVQIHTGAGDRDIKLELSRPSYLTNIVRKYEGKVIFVHAGYPYHRETAWMSYLFPSVYLDTSQVIPFAPLAAYNILNEIFEVAPLNKVMHGSDAFHIPEISWLAAKLAKKAIQKTTELMIEKNILDEKHAKEMVERFLYYNSKEMYGFD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	339 (323)
Sequences:	473 (339)
Seq/√Len:	18.9

SULSO - Q97VR0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
209_R	236_E	7.762	1.00
96_L	134_G	4.717	1.00
306_T	324_V	4.679	1.00
141_Y	283_D	4.230	1.00
73_I	280_H	3.978	1.00
171_K	175_D	3.649	1.00
325_E	330_Y	3.074	0.99
252_S	281_G	2.957	0.99
139_I	147_V	2.869	0.99
146_K	207_L	2.829	0.99
99_I	290_I	2.807	0.98
73_I	282_S	2.730	0.98
136_K	228_H	2.532	0.97
31_P	315_L	2.512	0.97
329_Y	333_K	2.436	0.96
138_I	142_R	2.291	0.95
136_K	283_D	2.246	0.94
115_A	123_L	2.204	0.93
302_I	328_L	2.203	0.93
234_H	268_E	2.190	0.93
18_E	283_D	2.188	0.93
43_L	292_W	2.145	0.92
64_M	288_P	2.122	0.92
84_K	87_M	2.122	0.92
273_A	278_V	1.996	0.89
284_A	290_I	1.988	0.89
228_H	283_D	1.935	0.88
80_T	95_L	1.923	0.87
82_F	225_I	1.899	0.87
182_L	216_I	1.883	0.86
262_A	301_A	1.810	0.84
225_I	335_M	1.800	0.84
263_Y	304_K	1.797	0.84
34_L	323_M	1.772	0.83
154_A	158_F	1.771	0.83
31_P	34_L	1.761	0.82
145_L	280_H	1.760	0.82
324_V	331_N	1.743	0.82
282_S	291_S	1.702	0.80
73_I	76_F	1.694	0.80
103_I	115_A	1.691	0.80
47_N	50_E	1.686	0.79
316_D	319_H	1.685	0.79
136_K	140_A	1.681	0.79
140_A	253_Q	1.681	0.79
145_L	194_I	1.670	0.79
195_H	283_D	1.670	0.79
81_G	98_R	1.643	0.78
143_T	178_L	1.640	0.77
158_F	189_R	1.613	0.76
71_A	295_A	1.611	0.76
52_R	56_I	1.610	0.76
154_A	160_S	1.598	0.76
266_L	301_A	1.580	0.75
266_L	298_A	1.559	0.74
199_G	283_D	1.554	0.73
198_A	253_Q	1.547	0.73
36_L	262_A	1.544	0.73
54_K	58_N	1.533	0.72
73_I	291_S	1.495	0.70
200_D	283_D	1.495	0.70
18_E	141_Y	1.486	0.70
179_C	182_L	1.474	0.69
298_A	328_L	1.470	0.69
34_L	315_L	1.461	0.69
141_Y	253_Q	1.455	0.68
136_K	195_H	1.437	0.67
214_T	218_R	1.430	0.67
82_F	285_F	1.407	0.66
152_E	187_E	1.395	0.65
315_L	323_M	1.377	0.64
182_L	194_I	1.370	0.63
204_K	209_R	1.357	0.63
204_K	211_S	1.357	0.63
205_L	283_D	1.351	0.62
27_N	276_N	1.347	0.62
142_R	202_D	1.347	0.62
141_Y	228_H	1.341	0.62
31_P	323_M	1.336	0.61
98_R	199_G	1.320	0.61
45_G	273_A	1.317	0.60
140_A	283_D	1.311	0.60
249_L	269_I	1.310	0.60
85_K	88_E	1.309	0.60
192_V	216_I	1.303	0.59
253_Q	283_D	1.301	0.59
152_E	160_S	1.299	0.59
30_R	34_L	1.294	0.59
192_V	257_F	1.288	0.59
306_T	320_A	1.278	0.58
157_D	160_S	1.265	0.57
75_G	94_K	1.265	0.57
185_A	332_S	1.261	0.57
292_W	296_K	1.258	0.57
226_F	247_V	1.257	0.57
73_I	243_L	1.256	0.57
60_P	246_S	1.249	0.56
196_T	285_F	1.239	0.56
138_I	253_Q	1.236	0.55
41_K	224_V	1.233	0.55
335_M	338_F	1.230	0.55
261_A	264_N	1.218	0.54
179_C	220_Y	1.213	0.54
142_R	200_D	1.211	0.54
137_S	142_R	1.210	0.54
17_N	52_R	1.194	0.53
217_V	221_E	1.191	0.53
145_L	196_T	1.189	0.52
227_V	252_S	1.182	0.52
202_D	283_D	1.175	0.52
118_Y	123_L	1.169	0.51
248_Y	311_E	1.163	0.51
133_A	338_F	1.160	0.51
255_I	262_A	1.156	0.50
84_K	88_E	1.147	0.50
199_G	205_L	1.144	0.50
143_T	147_V	1.137	0.49
98_R	200_D	1.137	0.49
200_D	205_L	1.134	0.49
197_G	228_H	1.132	0.49
245_P	324_V	1.118	0.48
287_I	302_I	1.117	0.48
16_E	36_L	1.116	0.48
138_I	200_D	1.111	0.47
141_Y	199_G	1.103	0.47
172_G	175_D	1.102	0.47
78_I	181_T	1.101	0.47
139_I	254_V	1.100	0.47
102_I	116_L	1.097	0.47
138_I	202_D	1.096	0.47
192_V	327_F	1.089	0.46
141_Y	200_D	1.086	0.46
254_V	335_M	1.085	0.46
279_M	332_S	1.081	0.46
326_R	330_Y	1.070	0.45
256_P	288_P	1.066	0.45
196_T	203_I	1.065	0.45
131_G	160_S	1.064	0.45
48_F	51_E	1.063	0.44
30_R	179_C	1.055	0.44
115_A	230_G	1.055	0.44
230_G	237_T	1.055	0.44
30_R	242_Y	1.055	0.44
141_Y	205_L	1.055	0.44
137_S	228_H	1.052	0.44
144_G	239_W	1.051	0.44
298_A	324_V	1.049	0.44
120_E	184_I	1.047	0.44
19_I	147_V	1.044	0.43
202_D	253_Q	1.039	0.43
98_R	283_D	1.038	0.43
191_P	225_I	1.035	0.43
136_K	141_Y	1.034	0.43
156_R	160_S	1.033	0.43
145_L	231_Y	1.025	0.42
138_I	282_S	1.022	0.42
139_I	185_A	1.022	0.42
168_K	173_F	1.022	0.42
260_L	314_I	1.017	0.42
317_E	321_K	1.013	0.41
251_T	278_V	1.013	0.41
12_E	115_A	1.011	0.41
111_S	114_K	1.010	0.41
197_G	283_D	1.008	0.41
200_D	253_Q	1.002	0.41
307_E	311_E	0.993	0.40
276_N	326_R	0.993	0.40
303_Q	318_K	0.991	0.40
214_T	244_F	0.990	0.40
140_A	198_A	0.988	0.40
200_D	239_W	0.986	0.40
26_M	268_E	0.983	0.40
144_G	200_D	0.975	0.39
137_S	144_G	0.973	0.39
157_D	161_N	0.971	0.39
138_I	141_Y	0.970	0.39
17_N	201_R	0.968	0.39
310_I	320_A	0.968	0.39
117_E	121_E	0.959	0.38
233_Y	236_E	0.957	0.38
113_D	117_E	0.954	0.38
227_V	336_Y	0.952	0.38
182_L	296_K	0.945	0.37
320_A	338_F	0.943	0.37
178_L	192_V	0.938	0.37
138_I	144_G	0.935	0.37
22_D	67_L	0.934	0.37
205_L	253_Q	0.933	0.37
163_K	308_L	0.933	0.37
98_R	144_G	0.930	0.36
81_G	277_K	0.928	0.36
42_L	158_F	0.927	0.36
54_K	76_F	0.927	0.36
49_I	327_F	0.925	0.36
204_K	215_N	0.921	0.36
140_A	228_H	0.921	0.36
17_N	23_T	0.920	0.36
73_I	185_A	0.920	0.36
112_F	125_R	0.919	0.36
222_G	268_E	0.918	0.36
313_N	326_R	0.911	0.35
228_H	232_P	0.909	0.35
120_E	180_E	0.902	0.35
228_H	231_Y	0.901	0.35
102_I	278_V	0.892	0.34
19_I	23_T	0.888	0.34
103_I	291_S	0.886	0.34
81_G	144_G	0.886	0.34
153_E	157_D	0.882	0.34
17_N	24_F	0.880	0.34
258_A	265_I	0.878	0.33
25_T	246_S	0.877	0.33
115_A	127_I	0.874	0.33
295_A	299_K	0.874	0.33
279_M	335_M	0.872	0.33
310_I	338_F	0.871	0.33
45_G	162_E	0.871	0.33
197_G	231_Y	0.866	0.33
315_L	331_N	0.866	0.33
155_R	159_H	0.865	0.33
18_E	136_K	0.863	0.33
173_F	221_E	0.862	0.33
217_V	239_W	0.853	0.32
17_N	21_T	0.851	0.32
98_R	195_H	0.849	0.32
139_I	294_A	0.848	0.32
215_N	218_R	0.847	0.32
143_T	242_Y	0.846	0.32
157_D	179_C	0.843	0.32
218_R	244_F	0.842	0.31
79_D	196_T	0.841	0.31
179_C	186_K	0.840	0.31
126_K	288_P	0.839	0.31
18_E	142_R	0.833	0.31
131_G	188_L	0.833	0.31
136_K	145_L	0.832	0.31
59_D	63_Y	0.831	0.31
37_R	319_H	0.830	0.31
266_L	271_E	0.827	0.31
319_H	322_E	0.823	0.30
202_D	205_L	0.821	0.30
231_Y	283_D	0.816	0.30
184_I	263_Y	0.816	0.30
83_G	86_E	0.814	0.30
133_A	192_V	0.814	0.30
112_F	115_A	0.811	0.30
320_A	331_N	0.811	0.30
134_G	239_W	0.811	0.30
135_F	338_F	0.808	0.30
141_Y	239_W	0.808	0.30
235_R	268_E	0.806	0.30
220_Y	246_S	0.805	0.29
19_I	284_A	0.804	0.29
269_I	278_V	0.799	0.29
135_F	225_I	0.798	0.29
154_A	157_D	0.794	0.29
305_T	308_L	0.791	0.29
131_G	321_K	0.790	0.29
56_I	102_I	0.783	0.28
161_N	266_L	0.782	0.28
254_V	265_I	0.782	0.28
209_R	212_Y	0.780	0.28
53_N	56_I	0.770	0.28
138_I	273_A	0.767	0.28
193_Q	227_V	0.762	0.27
313_N	319_H	0.762	0.27
76_F	208_S	0.759	0.27
44_L	269_I	0.759	0.27
273_A	295_A	0.758	0.27
137_S	274_P	0.756	0.27
53_N	78_I	0.756	0.27
44_L	223_K	0.756	0.27
76_F	298_A	0.755	0.27
144_G	235_R	0.752	0.27
22_D	150_N	0.752	0.27
14_W	187_E	0.749	0.27
35_Y	262_A	0.748	0.27
134_G	138_I	0.746	0.27
198_A	285_F	0.741	0.26
14_W	192_V	0.741	0.26
78_I	168_K	0.738	0.26
63_Y	252_S	0.727	0.26
25_T	276_N	0.726	0.26
116_L	120_E	0.724	0.25
258_A	281_G	0.723	0.25
133_A	263_Y	0.723	0.25
107_I	161_N	0.722	0.25
217_V	224_V	0.721	0.25
25_T	245_P	0.721	0.25
230_G	327_F	0.721	0.25
134_G	172_G	0.720	0.25
97_F	240_M	0.719	0.25
81_G	202_D	0.719	0.25
31_P	259_P	0.719	0.25
288_P	309_M	0.717	0.25
82_F	254_V	0.717	0.25
270_F	278_V	0.713	0.25
17_N	243_L	0.712	0.25
134_G	181_T	0.712	0.25
141_Y	202_D	0.711	0.25
109_Q	282_S	0.711	0.25
136_K	253_Q	0.708	0.25
119_F	293_L	0.706	0.25
136_K	231_Y	0.706	0.25
19_I	246_S	0.705	0.25
203_I	282_S	0.704	0.24
217_V	220_Y	0.704	0.24
79_D	256_P	0.703	0.24
98_R	141_Y	0.703	0.24
302_I	306_T	0.702	0.24
47_N	53_N	0.699	0.24
287_I	290_I	0.698	0.24
140_A	145_L	0.698	0.24
257_F	269_I	0.697	0.24
213_L	247_V	0.697	0.24
184_I	187_E	0.695	0.24
136_K	239_W	0.695	0.24
60_P	64_M	0.695	0.24
320_A	324_V	0.694	0.24
100_E	142_R	0.692	0.24
196_T	256_P	0.692	0.24
154_A	187_E	0.692	0.24
18_E	202_D	0.690	0.24
96_L	113_D	0.689	0.24
139_I	327_F	0.689	0.24
223_K	280_H	0.687	0.24
222_G	246_S	0.686	0.24
258_A	262_A	0.684	0.24
257_F	280_H	0.683	0.24
253_Q	284_A	0.682	0.23
140_A	200_D	0.682	0.23
281_G	291_S	0.682	0.23
107_I	189_R	0.679	0.23
173_F	215_N	0.678	0.23
79_D	269_I	0.678	0.23
106_D	324_V	0.678	0.23
111_S	125_R	0.677	0.23
72_G	154_A	0.675	0.23
313_N	320_A	0.675	0.23
256_P	305_T	0.675	0.23
200_D	231_Y	0.674	0.23
196_T	233_Y	0.671	0.23
130_E	160_S	0.671	0.23
243_L	291_S	0.670	0.23
144_G	227_V	0.670	0.23
252_S	336_Y	0.669	0.23
160_S	300_K	0.668	0.23
107_I	165_W	0.667	0.23
187_E	248_Y	0.664	0.23
278_V	292_W	0.659	0.22
251_T	294_A	0.655	0.22
196_T	204_K	0.651	0.22
71_A	329_Y	0.650	0.22
54_K	57_K	0.649	0.22
304_K	308_L	0.648	0.22
142_R	243_L	0.648	0.22
298_A	302_I	0.647	0.22
86_E	93_L	0.647	0.22
267_N	301_A	0.644	0.22
214_T	217_V	0.644	0.22
191_P	227_V	0.642	0.22
123_L	135_F	0.641	0.22
322_E	330_Y	0.639	0.22
198_A	236_E	0.635	0.21
14_W	292_W	0.634	0.21
82_F	135_F	0.633	0.21
45_G	66_L	0.632	0.21
54_K	164_D	0.630	0.21
304_K	312_K	0.625	0.21
251_T	269_I	0.625	0.21
137_S	205_L	0.623	0.21
287_I	298_A	0.623	0.21
71_A	273_A	0.622	0.21
313_N	323_M	0.622	0.21
210_P	235_R	0.622	0.21
111_S	155_R	0.621	0.21
97_F	203_I	0.617	0.21
116_L	123_L	0.617	0.21
262_A	297_L	0.617	0.21
29_L	275_L	0.616	0.21
155_R	158_F	0.616	0.21
137_S	194_I	0.612	0.20
178_L	216_I	0.609	0.20
299_K	331_N	0.609	0.20
136_K	197_G	0.608	0.20
84_K	333_K	0.607	0.20
137_S	199_G	0.606	0.20
145_L	254_V	0.604	0.20
149_C	183_R	0.604	0.20
97_F	132_Y	0.602	0.20
71_A	113_D	0.601	0.20
303_Q	317_E	0.600	0.20
132_Y	222_G	0.600	0.20
109_Q	112_F	0.597	0.20
12_E	16_E	0.596	0.20
147_V	214_T	0.595	0.20
140_A	195_H	0.592	0.20
160_S	173_F	0.592	0.20
214_T	262_A	0.589	0.20
171_K	292_W	0.588	0.19
29_L	33_Y	0.586	0.19
95_L	259_P	0.583	0.19
194_I	213_L	0.583	0.19
75_G	327_F	0.583	0.19
30_R	281_G	0.581	0.19
141_Y	232_P	0.581	0.19
288_P	335_M	0.580	0.19
235_R	279_M	0.579	0.19
31_P	260_L	0.577	0.19
109_Q	163_K	0.577	0.19
21_T	201_R	0.576	0.19
65_R	192_V	0.576	0.19
123_L	184_I	0.576	0.19
259_P	297_L	0.576	0.19
141_Y	195_H	0.575	0.19
310_I	323_M	0.575	0.19
182_L	248_Y	0.574	0.19
209_R	233_Y	0.572	0.19
153_E	158_F	0.572	0.19
306_T	331_N	0.572	0.19
112_F	123_L	0.569	0.19
114_K	118_Y	0.568	0.19
122_T	126_K	0.568	0.19
27_N	249_L	0.567	0.19
156_R	313_N	0.566	0.19
19_I	208_S	0.565	0.19
93_L	182_L	0.563	0.19
258_A	335_M	0.563	0.19
173_F	324_V	0.562	0.18
107_I	215_N	0.556	0.18
19_I	164_D	0.556	0.18
175_D	196_T	0.553	0.18
266_L	306_T	0.553	0.18
127_I	312_K	0.553	0.18
259_P	262_A	0.552	0.18
119_F	150_N	0.551	0.18
215_N	330_Y	0.550	0.18
57_K	66_L	0.548	0.18
26_M	276_N	0.544	0.18
136_K	202_D	0.544	0.18
96_L	239_W	0.543	0.18
43_L	179_C	0.543	0.18
291_S	298_A	0.542	0.18
239_W	253_Q	0.540	0.18
112_F	116_L	0.538	0.18
20_S	178_L	0.536	0.18
145_L	228_H	0.535	0.17
77_V	338_F	0.534	0.17
118_Y	324_V	0.533	0.17
102_I	257_F	0.533	0.17
41_K	239_W	0.532	0.17
166_F	251_T	0.530	0.17
116_L	133_A	0.528	0.17
43_L	90_P	0.527	0.17
144_G	253_Q	0.524	0.17
209_R	317_E	0.524	0.17
211_S	253_Q	0.524	0.17
36_L	65_R	0.523	0.17
116_L	173_F	0.522	0.17
103_I	281_G	0.522	0.17
191_P	329_Y	0.522	0.17
139_I	302_I	0.522	0.17
38_N	59_D	0.520	0.17
156_R	159_H	0.518	0.17
282_S	336_Y	0.517	0.17
141_Y	285_F	0.516	0.17
135_F	185_A	0.514	0.17
31_P	119_F	0.513	0.17
53_N	222_G	0.511	0.17
122_T	159_H	0.511	0.17
76_F	181_T	0.511	0.17
239_W	293_L	0.510	0.17
36_L	40_L	0.508	0.17
18_E	239_W	0.508	0.17
119_F	305_T	0.507	0.16
114_K	125_R	0.507	0.16
238_A	269_I	0.507	0.16
79_D	197_G	0.506	0.16
196_T	223_K	0.504	0.16
140_A	284_A	0.503	0.16
99_I	284_A	0.503	0.16
113_D	267_N	0.501	0.16
166_F	215_N	0.501	0.16
278_V	325_E	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i6vA	3	0.9676	100	0.535	Contact Map
2qpxA	3	0.9794	100	0.537	Contact Map
1j5sA	3	0.9705	100	0.559	Contact Map
2q01A	3	0.9676	100	0.592	Contact Map
3iacA	3	0.9853	100	0.619	Contact Map
2qeeA	5	0.9056	100	0.633	Contact Map
3irsA	3	0.8053	99.8	0.834	Contact Map
3ij6A	2	0.7965	99.7	0.849	Contact Map
4do7A	1	0.7699	99.6	0.854	Contact Map
3cjpA	2	0.6755	99.6	0.855	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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