GREMLIN Database
Q97VR0 - Uncharacterized protein
UniProt: Q97VR0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 339 (323)
Sequences: 473 (339)
Seq/√Len: 18.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
209_R236_E7.7621.00
96_L134_G4.7171.00
306_T324_V4.6791.00
141_Y283_D4.2301.00
73_I280_H3.9781.00
171_K175_D3.6491.00
325_E330_Y3.0740.99
252_S281_G2.9570.99
139_I147_V2.8690.99
146_K207_L2.8290.99
99_I290_I2.8070.98
73_I282_S2.7300.98
136_K228_H2.5320.97
31_P315_L2.5120.97
329_Y333_K2.4360.96
138_I142_R2.2910.95
136_K283_D2.2460.94
115_A123_L2.2040.93
302_I328_L2.2030.93
234_H268_E2.1900.93
18_E283_D2.1880.93
43_L292_W2.1450.92
64_M288_P2.1220.92
84_K87_M2.1220.92
273_A278_V1.9960.89
284_A290_I1.9880.89
228_H283_D1.9350.88
80_T95_L1.9230.87
82_F225_I1.8990.87
182_L216_I1.8830.86
262_A301_A1.8100.84
225_I335_M1.8000.84
263_Y304_K1.7970.84
34_L323_M1.7720.83
154_A158_F1.7710.83
31_P34_L1.7610.82
145_L280_H1.7600.82
324_V331_N1.7430.82
282_S291_S1.7020.80
73_I76_F1.6940.80
103_I115_A1.6910.80
47_N50_E1.6860.79
316_D319_H1.6850.79
136_K140_A1.6810.79
140_A253_Q1.6810.79
145_L194_I1.6700.79
195_H283_D1.6700.79
81_G98_R1.6430.78
143_T178_L1.6400.77
158_F189_R1.6130.76
71_A295_A1.6110.76
52_R56_I1.6100.76
154_A160_S1.5980.76
266_L301_A1.5800.75
266_L298_A1.5590.74
199_G283_D1.5540.73
198_A253_Q1.5470.73
36_L262_A1.5440.73
54_K58_N1.5330.72
73_I291_S1.4950.70
200_D283_D1.4950.70
18_E141_Y1.4860.70
179_C182_L1.4740.69
298_A328_L1.4700.69
34_L315_L1.4610.69
141_Y253_Q1.4550.68
136_K195_H1.4370.67
214_T218_R1.4300.67
82_F285_F1.4070.66
152_E187_E1.3950.65
315_L323_M1.3770.64
182_L194_I1.3700.63
204_K209_R1.3570.63
204_K211_S1.3570.63
205_L283_D1.3510.62
27_N276_N1.3470.62
142_R202_D1.3470.62
141_Y228_H1.3410.62
31_P323_M1.3360.61
98_R199_G1.3200.61
45_G273_A1.3170.60
140_A283_D1.3110.60
249_L269_I1.3100.60
85_K88_E1.3090.60
192_V216_I1.3030.59
253_Q283_D1.3010.59
152_E160_S1.2990.59
30_R34_L1.2940.59
192_V257_F1.2880.59
306_T320_A1.2780.58
157_D160_S1.2650.57
75_G94_K1.2650.57
185_A332_S1.2610.57
292_W296_K1.2580.57
226_F247_V1.2570.57
73_I243_L1.2560.57
60_P246_S1.2490.56
196_T285_F1.2390.56
138_I253_Q1.2360.55
41_K224_V1.2330.55
335_M338_F1.2300.55
261_A264_N1.2180.54
179_C220_Y1.2130.54
142_R200_D1.2110.54
137_S142_R1.2100.54
17_N52_R1.1940.53
217_V221_E1.1910.53
145_L196_T1.1890.52
227_V252_S1.1820.52
202_D283_D1.1750.52
118_Y123_L1.1690.51
248_Y311_E1.1630.51
133_A338_F1.1600.51
255_I262_A1.1560.50
84_K88_E1.1470.50
199_G205_L1.1440.50
143_T147_V1.1370.49
98_R200_D1.1370.49
200_D205_L1.1340.49
197_G228_H1.1320.49
245_P324_V1.1180.48
287_I302_I1.1170.48
16_E36_L1.1160.48
138_I200_D1.1110.47
141_Y199_G1.1030.47
172_G175_D1.1020.47
78_I181_T1.1010.47
139_I254_V1.1000.47
102_I116_L1.0970.47
138_I202_D1.0960.47
192_V327_F1.0890.46
141_Y200_D1.0860.46
254_V335_M1.0850.46
279_M332_S1.0810.46
326_R330_Y1.0700.45
256_P288_P1.0660.45
196_T203_I1.0650.45
131_G160_S1.0640.45
48_F51_E1.0630.44
30_R179_C1.0550.44
115_A230_G1.0550.44
230_G237_T1.0550.44
30_R242_Y1.0550.44
141_Y205_L1.0550.44
137_S228_H1.0520.44
144_G239_W1.0510.44
298_A324_V1.0490.44
120_E184_I1.0470.44
19_I147_V1.0440.43
202_D253_Q1.0390.43
98_R283_D1.0380.43
191_P225_I1.0350.43
136_K141_Y1.0340.43
156_R160_S1.0330.43
145_L231_Y1.0250.42
138_I282_S1.0220.42
139_I185_A1.0220.42
168_K173_F1.0220.42
260_L314_I1.0170.42
317_E321_K1.0130.41
251_T278_V1.0130.41
12_E115_A1.0110.41
111_S114_K1.0100.41
197_G283_D1.0080.41
200_D253_Q1.0020.41
307_E311_E0.9930.40
276_N326_R0.9930.40
303_Q318_K0.9910.40
214_T244_F0.9900.40
140_A198_A0.9880.40
200_D239_W0.9860.40
26_M268_E0.9830.40
144_G200_D0.9750.39
137_S144_G0.9730.39
157_D161_N0.9710.39
138_I141_Y0.9700.39
17_N201_R0.9680.39
310_I320_A0.9680.39
117_E121_E0.9590.38
233_Y236_E0.9570.38
113_D117_E0.9540.38
227_V336_Y0.9520.38
182_L296_K0.9450.37
320_A338_F0.9430.37
178_L192_V0.9380.37
138_I144_G0.9350.37
22_D67_L0.9340.37
205_L253_Q0.9330.37
163_K308_L0.9330.37
98_R144_G0.9300.36
81_G277_K0.9280.36
42_L158_F0.9270.36
54_K76_F0.9270.36
49_I327_F0.9250.36
204_K215_N0.9210.36
140_A228_H0.9210.36
17_N23_T0.9200.36
73_I185_A0.9200.36
112_F125_R0.9190.36
222_G268_E0.9180.36
313_N326_R0.9110.35
228_H232_P0.9090.35
120_E180_E0.9020.35
228_H231_Y0.9010.35
102_I278_V0.8920.34
19_I23_T0.8880.34
103_I291_S0.8860.34
81_G144_G0.8860.34
153_E157_D0.8820.34
17_N24_F0.8800.34
258_A265_I0.8780.33
25_T246_S0.8770.33
115_A127_I0.8740.33
295_A299_K0.8740.33
279_M335_M0.8720.33
310_I338_F0.8710.33
45_G162_E0.8710.33
197_G231_Y0.8660.33
315_L331_N0.8660.33
155_R159_H0.8650.33
18_E136_K0.8630.33
173_F221_E0.8620.33
217_V239_W0.8530.32
17_N21_T0.8510.32
98_R195_H0.8490.32
139_I294_A0.8480.32
215_N218_R0.8470.32
143_T242_Y0.8460.32
157_D179_C0.8430.32
218_R244_F0.8420.31
79_D196_T0.8410.31
179_C186_K0.8400.31
126_K288_P0.8390.31
18_E142_R0.8330.31
131_G188_L0.8330.31
136_K145_L0.8320.31
59_D63_Y0.8310.31
37_R319_H0.8300.31
266_L271_E0.8270.31
319_H322_E0.8230.30
202_D205_L0.8210.30
231_Y283_D0.8160.30
184_I263_Y0.8160.30
83_G86_E0.8140.30
133_A192_V0.8140.30
112_F115_A0.8110.30
320_A331_N0.8110.30
134_G239_W0.8110.30
135_F338_F0.8080.30
141_Y239_W0.8080.30
235_R268_E0.8060.30
220_Y246_S0.8050.29
19_I284_A0.8040.29
269_I278_V0.7990.29
135_F225_I0.7980.29
154_A157_D0.7940.29
305_T308_L0.7910.29
131_G321_K0.7900.29
56_I102_I0.7830.28
161_N266_L0.7820.28
254_V265_I0.7820.28
209_R212_Y0.7800.28
53_N56_I0.7700.28
138_I273_A0.7670.28
193_Q227_V0.7620.27
313_N319_H0.7620.27
76_F208_S0.7590.27
44_L269_I0.7590.27
273_A295_A0.7580.27
137_S274_P0.7560.27
53_N78_I0.7560.27
44_L223_K0.7560.27
76_F298_A0.7550.27
144_G235_R0.7520.27
22_D150_N0.7520.27
14_W187_E0.7490.27
35_Y262_A0.7480.27
134_G138_I0.7460.27
198_A285_F0.7410.26
14_W192_V0.7410.26
78_I168_K0.7380.26
63_Y252_S0.7270.26
25_T276_N0.7260.26
116_L120_E0.7240.25
258_A281_G0.7230.25
133_A263_Y0.7230.25
107_I161_N0.7220.25
217_V224_V0.7210.25
25_T245_P0.7210.25
230_G327_F0.7210.25
134_G172_G0.7200.25
97_F240_M0.7190.25
81_G202_D0.7190.25
31_P259_P0.7190.25
288_P309_M0.7170.25
82_F254_V0.7170.25
270_F278_V0.7130.25
17_N243_L0.7120.25
134_G181_T0.7120.25
141_Y202_D0.7110.25
109_Q282_S0.7110.25
136_K253_Q0.7080.25
119_F293_L0.7060.25
136_K231_Y0.7060.25
19_I246_S0.7050.25
203_I282_S0.7040.24
217_V220_Y0.7040.24
79_D256_P0.7030.24
98_R141_Y0.7030.24
302_I306_T0.7020.24
47_N53_N0.6990.24
287_I290_I0.6980.24
140_A145_L0.6980.24
257_F269_I0.6970.24
213_L247_V0.6970.24
184_I187_E0.6950.24
136_K239_W0.6950.24
60_P64_M0.6950.24
320_A324_V0.6940.24
100_E142_R0.6920.24
196_T256_P0.6920.24
154_A187_E0.6920.24
18_E202_D0.6900.24
96_L113_D0.6890.24
139_I327_F0.6890.24
223_K280_H0.6870.24
222_G246_S0.6860.24
258_A262_A0.6840.24
257_F280_H0.6830.24
253_Q284_A0.6820.23
140_A200_D0.6820.23
281_G291_S0.6820.23
107_I189_R0.6790.23
173_F215_N0.6780.23
79_D269_I0.6780.23
106_D324_V0.6780.23
111_S125_R0.6770.23
72_G154_A0.6750.23
313_N320_A0.6750.23
256_P305_T0.6750.23
200_D231_Y0.6740.23
196_T233_Y0.6710.23
130_E160_S0.6710.23
243_L291_S0.6700.23
144_G227_V0.6700.23
252_S336_Y0.6690.23
160_S300_K0.6680.23
107_I165_W0.6670.23
187_E248_Y0.6640.23
278_V292_W0.6590.22
251_T294_A0.6550.22
196_T204_K0.6510.22
71_A329_Y0.6500.22
54_K57_K0.6490.22
304_K308_L0.6480.22
142_R243_L0.6480.22
298_A302_I0.6470.22
86_E93_L0.6470.22
267_N301_A0.6440.22
214_T217_V0.6440.22
191_P227_V0.6420.22
123_L135_F0.6410.22
322_E330_Y0.6390.22
198_A236_E0.6350.21
14_W292_W0.6340.21
82_F135_F0.6330.21
45_G66_L0.6320.21
54_K164_D0.6300.21
304_K312_K0.6250.21
251_T269_I0.6250.21
137_S205_L0.6230.21
287_I298_A0.6230.21
71_A273_A0.6220.21
313_N323_M0.6220.21
210_P235_R0.6220.21
111_S155_R0.6210.21
97_F203_I0.6170.21
116_L123_L0.6170.21
262_A297_L0.6170.21
29_L275_L0.6160.21
155_R158_F0.6160.21
137_S194_I0.6120.20
178_L216_I0.6090.20
299_K331_N0.6090.20
136_K197_G0.6080.20
84_K333_K0.6070.20
137_S199_G0.6060.20
145_L254_V0.6040.20
149_C183_R0.6040.20
97_F132_Y0.6020.20
71_A113_D0.6010.20
303_Q317_E0.6000.20
132_Y222_G0.6000.20
109_Q112_F0.5970.20
12_E16_E0.5960.20
147_V214_T0.5950.20
140_A195_H0.5920.20
160_S173_F0.5920.20
214_T262_A0.5890.20
171_K292_W0.5880.19
29_L33_Y0.5860.19
95_L259_P0.5830.19
194_I213_L0.5830.19
75_G327_F0.5830.19
30_R281_G0.5810.19
141_Y232_P0.5810.19
288_P335_M0.5800.19
235_R279_M0.5790.19
31_P260_L0.5770.19
109_Q163_K0.5770.19
21_T201_R0.5760.19
65_R192_V0.5760.19
123_L184_I0.5760.19
259_P297_L0.5760.19
141_Y195_H0.5750.19
310_I323_M0.5750.19
182_L248_Y0.5740.19
209_R233_Y0.5720.19
153_E158_F0.5720.19
306_T331_N0.5720.19
112_F123_L0.5690.19
114_K118_Y0.5680.19
122_T126_K0.5680.19
27_N249_L0.5670.19
156_R313_N0.5660.19
19_I208_S0.5650.19
93_L182_L0.5630.19
258_A335_M0.5630.19
173_F324_V0.5620.18
107_I215_N0.5560.18
19_I164_D0.5560.18
175_D196_T0.5530.18
266_L306_T0.5530.18
127_I312_K0.5530.18
259_P262_A0.5520.18
119_F150_N0.5510.18
215_N330_Y0.5500.18
57_K66_L0.5480.18
26_M276_N0.5440.18
136_K202_D0.5440.18
96_L239_W0.5430.18
43_L179_C0.5430.18
291_S298_A0.5420.18
239_W253_Q0.5400.18
112_F116_L0.5380.18
20_S178_L0.5360.18
145_L228_H0.5350.17
77_V338_F0.5340.17
118_Y324_V0.5330.17
102_I257_F0.5330.17
41_K239_W0.5320.17
166_F251_T0.5300.17
116_L133_A0.5280.17
43_L90_P0.5270.17
144_G253_Q0.5240.17
209_R317_E0.5240.17
211_S253_Q0.5240.17
36_L65_R0.5230.17
116_L173_F0.5220.17
103_I281_G0.5220.17
191_P329_Y0.5220.17
139_I302_I0.5220.17
38_N59_D0.5200.17
156_R159_H0.5180.17
282_S336_Y0.5170.17
141_Y285_F0.5160.17
135_F185_A0.5140.17
31_P119_F0.5130.17
53_N222_G0.5110.17
122_T159_H0.5110.17
76_F181_T0.5110.17
239_W293_L0.5100.17
36_L40_L0.5080.17
18_E239_W0.5080.17
119_F305_T0.5070.16
114_K125_R0.5070.16
238_A269_I0.5070.16
79_D197_G0.5060.16
196_T223_K0.5040.16
140_A284_A0.5030.16
99_I284_A0.5030.16
113_D267_N0.5010.16
166_F215_N0.5010.16
278_V325_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i6vA 3 0.9676 100 0.535 Contact Map
2qpxA 3 0.9794 100 0.537 Contact Map
1j5sA 3 0.9705 100 0.559 Contact Map
2q01A 3 0.9676 100 0.592 Contact Map
3iacA 3 0.9853 100 0.619 Contact Map
2qeeA 5 0.9056 100 0.633 Contact Map
3irsA 3 0.8053 99.8 0.834 Contact Map
3ij6A 2 0.7965 99.7 0.849 Contact Map
4do7A 1 0.7699 99.6 0.854 Contact Map
3cjpA 2 0.6755 99.6 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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