GREMLIN Database
Q97VQ9 - Glutamine synthetase (Glutamate ammonia ligase) (GS). (GlnA-3)
UniProt: Q97VQ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (407)
Sequences: 6245 (3240)
Seq/√Len: 160.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
386_R408_L4.9391.00
265_A355_L4.6171.00
160_E214_H4.0051.00
263_F347_G3.7671.00
237_I263_F3.7571.00
349_D353_R3.6871.00
115_K352_E3.5211.00
114_E118_E3.4301.00
93_N110_I3.3591.00
262_N354_G3.2871.00
96_K99_N3.0961.00
269_E353_R2.9261.00
392_V397_K2.7691.00
112_T345_E2.7021.00
157_I161_I2.6861.00
5_K9_E2.6501.00
133_Y180_G2.6421.00
420_D424_E2.6231.00
397_K401_G2.5911.00
191_K199_E2.5551.00
108_I399_I2.5361.00
273_A388_D2.5351.00
207_A218_A2.4821.00
114_E117_K2.4741.00
160_E213_K2.4681.00
126_S340_L2.4661.00
273_A391_L2.4151.00
246_L259_L2.3371.00
191_K195_R2.3181.00
258_D354_G2.2851.00
237_I343_V2.2571.00
241_K244_Q2.2381.00
262_N265_A2.1961.00
383_N408_L2.1731.00
270_H349_D2.1721.00
377_N380_E2.1631.00
270_H388_D2.1561.00
277_I342_A2.1401.00
195_R199_E2.1321.00
261_Y356_K2.1241.00
113_I194_L2.0961.00
117_K123_D2.0731.00
6_E10_K2.0711.00
278_A339_L2.0671.00
276_A385_L2.0661.00
165_L206_V2.0061.00
161_I207_A2.0041.00
272_K372_D1.9551.00
192_D195_R1.9541.00
379_R415_E1.9501.00
134_L157_I1.9451.00
168_I206_V1.9191.00
113_I193_A1.9071.00
376_R380_E1.9051.00
135_T225_F1.8851.00
17_F92_C1.8741.00
256_L260_A1.8041.00
34_D166_R1.8021.00
116_A124_F1.7871.00
13_E163_K1.7841.00
413_E425_V1.7781.00
171_E189_M1.7391.00
258_D262_N1.7271.00
102_N398_E1.7251.00
133_Y231_S1.7081.00
385_L400_I1.7021.00
262_N355_L1.7011.00
113_I192_D1.6911.00
274_L278_A1.6891.00
197_A340_L1.6821.00
265_A357_P1.6691.00
384_E387_K1.6651.00
259_L351_I1.6451.00
125_K240_W1.6381.00
379_R383_N1.6151.00
270_H346_A1.6141.00
277_I385_L1.6111.00
40_L78_L1.6071.00
382_L404_I1.5991.00
164_T210_V1.5861.00
203_F207_A1.5841.00
334_T339_L1.5741.00
380_E383_N1.5741.00
130_I200_V1.5691.00
108_I341_T1.5611.00
7_L33_I1.5541.00
272_K384_E1.5491.00
12_V83_V1.5481.00
125_K190_H1.5471.00
252_D261_Y1.5331.00
364_N367_Y1.5221.00
80_T91_I1.5161.00
75_T95_Y1.5111.00
110_I194_L1.5041.00
116_A348_L1.5001.00
124_F344_I1.4901.00
122_F246_L1.4871.00
390_K394_R1.4671.00
297_K301_G1.4541.00
164_T167_Q1.4471.00
18_T89_I1.4371.00
269_E355_L1.4361.00
388_D392_V1.4321.00
345_E394_R1.4071.00
112_T341_T1.4011.00
188_I196_S1.3941.00
196_S199_E1.3901.00
165_L170_I1.3881.00
262_N356_K1.3821.00
10_K86_P1.3571.00
389_T393_E1.3431.00
276_A382_L1.3331.00
134_L211_A1.3321.00
137_D212_S1.3241.00
89_I202_I1.3171.00
258_D356_K1.3161.00
112_T115_K1.3141.00
258_D261_Y1.3111.00
81_L88_A1.2961.00
386_R404_I1.2911.00
261_Y357_P1.2871.00
20_V201_V1.2861.00
275_T279_S1.2781.00
412_E415_E1.2691.00
363_E366_Y1.2651.00
327_Y343_V1.2631.00
279_S284_S1.2541.00
383_N386_R1.2531.00
237_I347_G1.2501.00
259_L262_N1.2491.00
309_I325_I1.2471.00
136_K216_V1.2381.00
140_P144_A1.2371.00
383_N387_K1.2351.00
104_D107_S1.2261.00
180_G229_A1.2251.00
178_E185_E1.2211.00
392_V401_G1.2201.00
110_I114_E1.2191.00
264_I325_I1.2171.00
191_K196_S1.2121.00
7_L36_V1.1871.00
115_K345_E1.1831.00
263_F348_L1.1831.00
274_L342_A1.1801.00
206_V210_V1.1751.00
26_I91_I1.1721.00
77_D93_N1.1671.00
414_Y421_W1.1671.00
160_E164_T1.1651.00
272_K275_T1.1601.00
296_T301_G1.1601.00
265_A358_P1.1601.00
13_E166_R1.1471.00
275_T329_V1.1391.00
12_V88_A1.1391.00
296_T299_T1.1371.00
392_V400_I1.1271.00
264_I309_I1.1261.00
386_R401_G1.1251.00
74_L94_L1.1241.00
407_K410_E1.1231.00
181_P228_L1.1061.00
272_K380_E1.1021.00
210_V214_H1.1001.00
273_A384_E1.0971.00
174_R187_D1.0961.00
221_M283_N1.0911.00
141_L144_A1.0911.00
134_L218_A1.0870.99
274_L346_A1.0870.99
270_H353_R1.0810.99
235_L343_V1.0770.99
412_E416_S1.0700.99
285_Y378_L1.0660.99
404_I408_L1.0660.99
409_A413_E1.0590.99
271_A308_M1.0590.99
74_L92_C1.0450.99
173_I189_M1.0420.99
263_F343_V1.0390.99
122_F259_L1.0380.99
133_Y229_A1.0330.99
164_T213_K1.0300.99
164_T206_V1.0250.99
401_G405_K1.0230.99
15_L36_V1.0210.99
268_L309_I1.0120.99
284_S331_D1.0110.99
414_Y419_T1.0110.99
5_K8_R1.0070.99
226_N418_V1.0020.99
109_L193_A1.0010.99
179_Y229_A0.9920.99
257_S260_A0.9820.99
100_P107_S0.9760.99
418_V422_E0.9760.99
157_I210_V0.9750.99
211_A218_A0.9740.99
21_G27_R0.9730.99
286_K422_E0.9700.99
385_L404_I0.9640.99
419_T422_E0.9630.99
275_T278_A0.9620.99
388_D391_L0.9620.99
385_L391_L0.9620.99
235_L339_L0.9610.99
276_A403_F0.9580.99
185_E234_H0.9530.99
308_M329_V0.9520.99
188_I203_F0.9510.99
26_I201_V0.9430.99
247_F260_A0.9430.99
178_E234_H0.9420.99
361_V365_A0.9410.99
411_V415_E0.9390.98
145_R148_D0.9390.98
135_T219_N0.9370.98
248_Y255_G0.9350.98
162_A175_I0.9320.98
276_A279_S0.9260.98
82_S89_I0.9250.98
399_I403_F0.9230.98
186_F203_F0.9210.98
265_A356_K0.9190.98
222_P331_D0.9190.98
389_T397_K0.9160.98
382_L408_L0.9140.98
116_A239_L0.9140.98
261_Y265_A0.9120.98
68_Q364_N0.9090.98
157_I216_V0.9070.98
122_F239_L0.9050.98
222_P333_S0.9010.98
168_I202_I0.9000.98
282_I378_L0.8940.98
108_I112_T0.8910.98
4_E37_D0.8900.98
66_G69_D0.8850.98
319_S322_D0.8850.98
349_D393_E0.8840.98
155_N159_P0.8810.98
299_T302_Y0.8740.98
386_R397_K0.8720.98
267_L309_I0.8720.98
403_F407_K0.8710.98
96_K102_N0.8680.97
129_E178_E0.8670.97
263_F267_L0.8660.97
274_L391_L0.8660.97
262_N351_I0.8660.97
386_R389_T0.8640.97
272_K298_I0.8630.97
200_V233_L0.8620.97
291_G294_A0.8600.97
124_F239_L0.8560.97
146_C176_I0.8560.97
382_L411_V0.8540.97
103_Y398_E0.8540.97
31_A39_L0.8540.97
104_D108_I0.8500.97
128_F200_V0.8490.97
417_L421_W0.8490.97
299_T371_I0.8470.97
37_D41_K0.8450.97
382_L407_K0.8440.97
391_L400_I0.8410.97
126_S196_S0.8400.97
79_N195_R0.8380.97
129_E185_E0.8370.97
126_S263_F0.8370.97
113_I124_F0.8350.97
402_E405_K0.8340.97
299_T307_A0.8330.97
123_D192_D0.8320.97
146_C153_Y0.8310.97
307_A365_A0.8300.97
295_P328_R0.8300.97
237_I327_Y0.8270.97
160_E210_V0.8250.97
299_T365_A0.8250.97
95_Y100_P0.8240.97
157_I214_H0.8240.97
360_A363_E0.8230.97
34_D171_E0.8160.96
379_R411_V0.8140.96
379_R408_L0.8110.96
123_D241_K0.8110.96
408_L412_E0.8100.96
384_E388_D0.8100.96
4_E8_R0.8090.96
389_T392_V0.8060.96
124_F237_I0.8040.96
239_L246_L0.8040.96
302_Y360_A0.8040.96
15_L33_I0.8010.96
35_H38_E0.7970.96
304_N366_Y0.7960.96
312_P324_R0.7960.96
112_T394_R0.7950.96
10_K81_L0.7890.96
129_E236_N0.7890.96
273_A390_K0.7890.96
267_L325_I0.7880.96
45_G314_P0.7860.96
123_D240_W0.7850.95
112_T116_A0.7830.95
226_N417_L0.7780.95
359_E362_N0.7740.95
95_Y107_S0.7740.95
7_L15_L0.7730.95
163_K167_Q0.7730.95
271_A309_I0.7700.95
240_W246_L0.7690.95
281_T333_S0.7670.95
304_N364_N0.7660.95
391_L395_I0.7660.95
163_K166_R0.7650.95
342_A395_I0.7630.95
156_Q214_H0.7630.95
274_L279_S0.7610.95
270_H273_A0.7600.95
84_F89_I0.7600.95
132_F161_I0.7590.95
14_I162_A0.7590.95
107_S111_K0.7580.95
277_I400_I0.7540.94
414_Y425_V0.7500.94
274_L277_I0.7400.94
172_P186_F0.7350.94
339_L342_A0.7350.94
277_I395_I0.7340.94
93_N104_D0.7340.94
270_H274_L0.7330.94
341_T395_I0.7310.93
349_D390_K0.7300.93
395_I400_I0.7300.93
235_L340_L0.7290.93
400_I404_I0.7260.93
409_A412_E0.7250.93
414_Y417_L0.7250.93
254_Y302_Y0.7230.93
179_Y293_W0.7210.93
126_S197_A0.7210.93
314_P322_D0.7170.93
124_F193_A0.7170.93
131_E178_E0.7150.93
116_A122_F0.7130.93
170_I188_I0.7130.93
222_P284_S0.7120.93
39_L44_I0.7100.92
267_L327_Y0.7100.92
396_G399_I0.7090.92
277_I403_F0.7090.92
10_K83_V0.7060.92
297_K302_Y0.7060.92
387_K390_K0.7030.92
413_E416_S0.7020.92
238_S324_R0.7020.92
16_R28_S0.7010.92
239_L344_I0.6970.92
397_K400_I0.6950.92
99_N102_N0.6940.92
418_V421_W0.6940.92
108_I111_K0.6940.92
260_A264_I0.6930.91
275_T374_I0.6910.91
102_N107_S0.6910.91
297_K300_Y0.6900.91
305_K328_R0.6900.91
349_D355_L0.6900.91
36_V90_V0.6890.91
147_F153_Y0.6890.91
271_A274_L0.6870.91
221_M286_K0.6860.91
399_I402_E0.6850.91
45_G73_F0.6810.91
77_D110_I0.6780.91
273_A276_A0.6760.90
306_S365_A0.6750.90
14_I163_K0.6750.90
113_I117_K0.6740.90
162_A172_P0.6720.90
131_E234_H0.6710.90
171_E199_E0.6690.90
361_V366_Y0.6680.90
83_V86_P0.6670.90
145_R153_Y0.6640.90
368_R371_I0.6610.89
282_I414_Y0.6590.89
107_S110_I0.6590.89
269_E372_D0.6560.89
286_K414_Y0.6550.89
348_L352_E0.6550.89
134_L161_I0.6540.89
23_D406_V0.6530.89
241_K259_L0.6530.89
200_V340_L0.6520.89
158_I175_I0.6500.89
270_H355_L0.6500.89
300_Y311_I0.6500.89
306_S366_Y0.6470.88
109_L341_T0.6470.88
165_L203_F0.6460.88
78_L90_V0.6450.88
290_P296_T0.6450.88
14_I30_G0.6410.88
225_F228_L0.6400.88
222_P281_T0.6400.88
289_V296_T0.6390.88
275_T375_P0.6390.88
102_N396_G0.6390.88
223_K230_G0.6390.88
47_T50_M0.6380.88
241_K246_L0.6370.88
31_A44_I0.6370.88
137_D217_E0.6370.88
131_E185_E0.6360.88
126_S237_I0.6360.88
126_S193_A0.6320.87
12_V86_P0.6320.87
262_N357_P0.6310.87
80_T85_P0.6300.87
96_K101_W0.6300.87
421_W425_V0.6290.87
178_E236_N0.6280.87
252_D255_G0.6270.87
170_I202_I0.6270.87
129_E234_H0.6270.87
197_A336_P0.6240.87
161_I186_F0.6240.87
17_F39_L0.6240.87
100_P110_I0.6230.87
146_C149_P0.6230.87
146_C151_A0.6220.86
237_I267_L0.6220.86
204_K208_R0.6220.86
324_R328_R0.6210.86
111_K396_G0.6210.86
77_D80_T0.6210.86
130_I203_F0.6190.86
127_A187_D0.6190.86
190_H238_S0.6190.86
406_V409_A0.6180.86
18_T26_I0.6160.86
260_A266_G0.6150.86
111_K114_E0.6130.86
116_A344_I0.6120.86
266_G351_I0.6120.86
89_I168_I0.6110.85
347_G350_G0.6110.85
130_I188_I0.6100.85
159_P163_K0.6100.85
352_E355_L0.6070.85
19_W74_L0.6070.85
295_P306_S0.6070.85
154_N212_S0.6060.85
271_A298_I0.6060.85
125_K238_S0.6030.85
282_I422_E0.6030.85
25_Y208_R0.6010.85
393_E396_G0.6010.85
247_F344_I0.6010.85
301_G307_A0.5990.84
17_F44_I0.5990.84
360_A366_Y0.5960.84
47_T293_W0.5950.84
82_S202_I0.5950.84
378_L382_L0.5950.84
172_P175_I0.5940.84
249_S255_G0.5940.84
298_I308_M0.5930.84
210_V213_K0.5930.84
22_L399_I0.5920.84
87_S159_P0.5920.84
280_P284_S0.5910.84
401_G404_I0.5910.84
133_Y228_L0.5910.84
267_L343_V0.5910.84
146_C154_N0.5900.83
63_G69_D0.5890.83
396_G400_I0.5890.83
190_H193_A0.5880.83
413_E421_W0.5880.83
344_I348_L0.5880.83
402_E406_V0.5880.83
36_V78_L0.5880.83
393_E397_K0.5880.83
375_P378_L0.5870.83
282_I411_V0.5870.83
296_T302_Y0.5860.83
147_F154_N0.5840.83
282_I419_T0.5820.83
236_N324_R0.5820.83
205_E209_Q0.5820.83
161_I206_V0.5800.82
134_L216_V0.5770.82
13_E167_Q0.5760.82
129_E305_K0.5750.82
127_A176_I0.5720.82
256_L261_Y0.5700.81
16_R205_E0.5670.81
183_Q231_S0.5670.81
289_V292_S0.5660.81
271_A329_V0.5660.81
16_R30_G0.5660.81
231_S332_P0.5650.81
6_E81_L0.5650.81
176_I179_Y0.5640.81
173_I190_H0.5640.81
147_F150_S0.5630.81
136_K141_L0.5620.80
35_H171_E0.5610.80
240_W243_N0.5590.80
173_I187_D0.5570.80
273_A385_L0.5560.80
142_D182_G0.5560.80
346_A350_G0.5530.79
230_G287_R0.5530.79
111_K115_K0.5520.79
278_A388_D0.5490.79
330_P339_L0.5490.79
91_I202_I0.5490.79
388_D397_K0.5470.79
135_T224_P0.5470.79
67_P293_W0.5470.79
385_L388_D0.5470.79
127_A238_S0.5460.78
64_T67_P0.5460.78
209_Q212_S0.5430.78
127_A190_H0.5430.78
226_N416_S0.5430.78
283_N422_E0.5410.78
170_I203_F0.5410.78
13_E86_P0.5400.78
170_I200_V0.5400.78
365_A373_D0.5400.78
347_G351_I0.5390.78
370_D373_D0.5390.78
46_L74_L0.5390.78
170_I199_E0.5370.77
379_R386_R0.5370.77
261_Y300_Y0.5360.77
411_V414_Y0.5350.77
35_H173_I0.5350.77
82_S195_R0.5340.77
8_R118_E0.5340.77
394_R399_I0.5340.77
234_H326_E0.5330.77
249_S261_Y0.5330.77
128_F233_L0.5330.77
7_L12_V0.5330.77
165_L172_P0.5320.77
418_V423_Y0.5310.77
173_I238_S0.5310.77
133_Y223_K0.5310.77
129_E326_E0.5290.76
19_W94_L0.5290.76
150_S153_Y0.5280.76
254_Y261_Y0.5280.76
147_F151_A0.5280.76
377_N411_V0.5270.76
273_A389_T0.5270.76
40_L90_V0.5260.76
145_R154_N0.5250.76
132_F186_F0.5240.76
49_A293_W0.5220.75
18_T202_I0.5210.75
84_F168_I0.5210.75
126_S235_L0.5210.75
241_K245_N0.5200.75
185_E326_E0.5180.75
282_I421_W0.5180.75
348_L351_I0.5180.75
190_H324_R0.5170.75
11_G86_P0.5150.74
81_L90_V0.5140.74
17_F90_V0.5140.74
6_E83_V0.5140.74
296_T300_Y0.5130.74
83_V88_A0.5120.74
109_L194_L0.5120.74
262_N269_E0.5120.74
27_R148_D0.5120.74
305_K326_E0.5110.74
262_N266_G0.5100.74
145_R150_S0.5100.74
278_A346_A0.5100.74
17_F31_A0.5090.74
302_Y362_N0.5090.74
408_L411_V0.5090.74
292_S416_S0.5090.74
64_T70_E0.5090.74
413_E417_L0.5070.73
140_P143_D0.5070.73
14_I159_P0.5060.73
166_R172_P0.5060.73
85_P168_I0.5050.73
151_A158_I0.5050.73
244_Q321_L0.5050.73
320_Q323_R0.5050.73
304_N361_V0.5040.73
179_Y292_S0.5040.73
278_A329_V0.5030.73
414_Y422_E0.5030.73
29_K147_F0.5030.73
137_D215_G0.5020.73
157_I211_A0.5010.72
269_E349_D0.5000.72
285_Y381_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lniA 5 0.965 100 0.104 Contact Map
4s17A 5 0.9301 100 0.109 Contact Map
4acfA 5 0.9697 100 0.11 Contact Map
1f52A 5 0.965 100 0.117 Contact Map
3ng0A 5 0.9604 100 0.121 Contact Map
4hppA 3 0.958 100 0.134 Contact Map
2j9iA 5 0.9394 100 0.17 Contact Map
3o6xA 3 0.8228 100 0.328 Contact Map
3fkyA 8 0.7273 100 0.356 Contact Map
4baxA 5 0.7389 100 0.361 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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