GREMLIN Database
Q97VQ4 - Dihydrolipoamide dehydrogenase (PdhD-4)
UniProt: Q97VQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (403)
Sequences: 14913 (9878)
Seq/√Len: 492.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_I232_A4.7811.00
260_D264_R4.1211.00
31_E103_I3.8801.00
152_S175_E3.3861.00
361_A375_I3.2171.00
177_V209_Y3.0071.00
175_E207_R2.8981.00
132_E242_K2.8191.00
198_T202_S2.7431.00
130_Y246_Q2.7041.00
323_S328_C2.6251.00
15_A124_V2.5801.00
374_L393_A2.5671.00
356_D386_N2.5571.00
120_V123_V2.5351.00
130_Y244_S2.4521.00
250_E258_I2.4361.00
191_K326_G2.4291.00
154_I179_V2.4181.00
27_L100_I2.4081.00
357_K382_N2.3911.00
149_D174_K2.3731.00
261_E302_V2.3501.00
152_S233_D2.3101.00
4_A118_I2.3031.00
3_I19_L2.2911.00
139_Y142_D2.2821.00
209_Y228_E2.2461.00
218_K223_I2.2241.00
135_K216_E2.1751.00
292_A296_I2.1181.00
122_Y269_N2.0851.00
378_L383_I2.0851.00
252_N256_F2.0781.00
4_A29_E2.0601.00
216_E223_I2.0491.00
183_S211_N2.0371.00
107_R117_T2.0241.00
363_A368_A2.0101.00
11_A273_A2.0041.00
130_Y242_K1.9671.00
138_I146_L1.9361.00
163_V178_L1.9301.00
170_R175_E1.9241.00
106_L123_V1.9101.00
181_K213_S1.8951.00
328_C352_C1.8541.00
124_V296_I1.8501.00
4_A120_V1.8381.00
153_V174_K1.8141.00
264_R268_S1.8021.00
29_E118_I1.7711.00
153_V169_L1.7571.00
138_I142_D1.7551.00
110_Q117_T1.7541.00
325_E350_K1.7501.00
213_S225_E1.7481.00
351_L361_A1.7461.00
184_S194_S1.7201.00
2_K121_D1.7171.00
2_K25_V1.7071.00
215_K225_E1.7061.00
170_R206_V1.6891.00
69_D72_E1.6781.00
317_T369_E1.6731.00
212_R226_N1.6601.00
4_A27_L1.6481.00
252_N258_I1.6451.00
215_K223_I1.6391.00
154_I222_V1.6321.00
384_K387_E1.6231.00
209_Y212_R1.6221.00
163_V314_T1.6141.00
271_F295_N1.6081.00
177_V207_R1.5881.00
196_A364_F1.5871.00
110_Q119_Q1.5811.00
3_I24_K1.5771.00
223_I229_K1.5751.00
6_I104_A1.5511.00
122_Y296_I1.5471.00
72_E75_K1.5411.00
125_L276_I1.5261.00
151_K233_D1.5151.00
262_Y295_N1.5081.00
190_D350_K1.4991.00
127_T276_I1.4961.00
18_E294_T1.4891.00
200_Y203_K1.4801.00
55_L58_E1.4561.00
263_L277_I1.4521.00
138_I143_L1.4521.00
146_L150_F1.4511.00
138_I234_V1.4511.00
34_L99_V1.4241.00
179_V230_L1.4181.00
142_D145_Y1.4181.00
59_L62_L1.4171.00
171_K204_I1.4121.00
100_I118_I1.4121.00
151_K175_E1.4101.00
89_E101_H1.4071.00
3_I124_V1.3961.00
27_L118_I1.3801.00
217_M235_V1.3741.00
381_Y387_E1.3681.00
192_E330_K1.3671.00
112_I115_N1.3471.00
294_T301_K1.3451.00
191_K195_N1.3441.00
264_R269_N1.3431.00
158_G185_L1.3401.00
267_L270_V1.3381.00
192_E350_K1.3381.00
133_V139_Y1.3371.00
198_T208_L1.3371.00
102_G113_V1.3261.00
78_Q82_Y1.3221.00
199_N202_S1.2931.00
184_S191_K1.2671.00
189_L310_K1.2611.00
198_T210_L1.2601.00
224_L230_L1.2601.00
143_L169_L1.2571.00
124_V273_A1.2571.00
310_K320_Y1.2471.00
28_V92_L1.2441.00
6_I125_L1.2311.00
289_G293_A1.2281.00
108_S111_L1.2271.00
75_K79_D1.2241.00
349_L401_A1.2241.00
193_V364_F1.2241.00
25_V98_E1.2191.00
184_S198_T1.2161.00
351_L375_I1.2141.00
152_S177_V1.2081.00
262_Y302_V1.2071.00
257_V276_I1.2031.00
189_L320_Y1.1951.00
319_A372_I1.1951.00
74_R78_Q1.1911.00
105_S112_I1.1811.00
209_Y230_L1.1761.00
373_S394_P1.1751.00
197_I364_F1.1751.00
156_V235_V1.1721.00
311_V369_E1.1721.00
356_D385_V1.1631.00
193_V348_F1.1591.00
41_Y141_E1.1571.00
273_A292_A1.1541.00
220_K231_T1.1531.00
333_L365_M1.1481.00
323_S327_K1.1481.00
89_E93_E1.1461.00
375_I402_L1.1431.00
180_D210_L1.1411.00
367_D370_E1.1301.00
79_D83_R1.1281.00
311_V394_P1.1281.00
178_L208_L1.1221.00
100_I116_E1.1211.00
105_S249_E1.1191.00
212_R228_E1.1161.00
349_L363_A1.1071.00
318_I364_F1.1071.00
112_I117_T1.1071.00
153_V234_V1.1051.00
383_I387_E1.1031.00
51_H55_L1.0901.00
292_A295_N1.0881.00
158_G180_D1.0871.00
199_N203_K1.0841.00
203_K346_D1.0811.00
307_G379_I1.0771.00
103_I247_G1.0721.00
152_S174_K1.0701.00
263_L292_A1.0661.00
18_E22_N1.0611.00
373_S399_I1.0591.00
218_K229_K1.0541.00
291_I303_F1.0541.00
88_V92_L1.0481.00
193_V362_Q1.0461.00
258_I266_S1.0451.00
154_I230_L1.0431.00
324_M327_K1.0401.00
156_V237_M1.0401.00
321_V379_I1.0381.00
137_I217_M1.0361.00
152_S231_T1.0351.00
132_E239_F1.0311.00
17_L95_N1.0281.00
185_L210_L1.0271.00
106_L125_L1.0241.00
106_L120_V1.0231.00
123_V270_V1.0191.00
8_S34_L1.0191.00
179_V224_L1.0171.00
156_V239_F1.0101.00
325_E352_C1.0101.00
196_A200_Y1.0061.00
200_Y204_I1.0061.00
22_N297_M1.0041.00
70_L74_R1.0031.00
224_L227_G1.0001.00
293_A297_M1.0001.00
122_Y271_F0.9941.00
98_E116_E0.9891.00
11_A285_A0.9831.00
195_N198_T0.9801.00
107_R110_Q0.9781.00
212_R224_L0.9771.00
29_E104_A0.9751.00
196_A199_N0.9751.00
185_L198_T0.9721.00
24_K121_D0.9701.00
56_A60_E0.9681.00
264_R271_F0.9661.00
24_K297_M0.9661.00
202_S207_R0.9621.00
197_I318_I0.9621.00
32_E41_Y0.9611.00
259_V277_I0.9591.00
185_L208_L0.9591.00
304_N380_R0.9591.00
291_I295_N0.9581.00
24_K122_Y0.9571.00
163_V201_F0.9461.00
177_V232_A0.9451.00
22_N294_T0.9381.00
259_V272_A0.9381.00
170_R204_I0.9341.00
140_S144_P0.9321.00
92_L99_V0.9291.00
319_A368_A0.9291.00
152_S232_A0.9271.00
374_L377_F0.9221.00
82_Y86_K0.9221.00
250_E266_S0.9201.00
57_S204_I0.9201.00
153_V236_Y0.9171.00
207_R228_E0.9151.00
71_G147_N0.9141.00
57_S61_K0.9111.00
138_I150_F0.9091.00
243_P256_F0.9081.00
74_R77_G0.9071.00
141_E144_P0.9071.00
358_I375_I0.9031.00
109_G267_L0.9031.00
148_K234_V0.9021.00
264_R295_N0.9011.00
19_L24_K0.9011.00
54_H58_E0.9011.00
18_E21_K0.9001.00
38_C43_C0.9001.00
162_G180_D0.8991.00
294_T299_G0.8971.00
328_C359_V0.8941.00
336_L339_A0.8931.00
182_Q187_P0.8921.00
332_N335_E0.8921.00
92_L97_V0.8921.00
184_S326_G0.8891.00
190_D362_Q0.8891.00
4_A123_V0.8881.00
200_Y364_F0.8871.00
52_P76_L0.8861.00
90_Y94_D0.8841.00
272_A276_I0.8831.00
71_G75_K0.8821.00
124_V292_A0.8811.00
338_R341_T0.8751.00
330_K348_F0.8741.00
317_T367_D0.8741.00
201_F206_V0.8741.00
245_I251_I0.8741.00
262_Y300_K0.8731.00
378_L388_I0.8731.00
184_S195_N0.8651.00
14_S286_M0.8651.00
179_V212_R0.8631.00
86_K89_E0.8621.00
179_V209_Y0.8601.00
40_L85_S0.8561.00
107_R112_I0.8551.00
143_L146_L0.8521.00
166_G178_L0.8511.00
224_L228_E0.8501.00
52_P73_L0.8491.00
57_S60_E0.8471.00
87_G91_M0.8461.00
19_L293_A0.8451.00
64_K67_T0.8451.00
2_K27_L0.8441.00
106_L249_E0.8431.00
2_K24_K0.8411.00
253_H258_I0.8381.00
4_A111_L0.8381.00
259_V263_L0.8381.00
212_R225_E0.8381.00
109_G269_N0.8331.00
29_E102_G0.8321.00
200_Y346_D0.8311.00
155_I236_Y0.8311.00
156_V214_V0.8301.00
357_K384_K0.8251.00
77_G81_S0.8201.00
8_S28_V0.8201.00
4_A112_I0.8181.00
140_S143_L0.8181.00
380_R390_D0.8171.00
50_L168_M0.8161.00
24_K296_I0.8161.00
358_I379_I0.8151.00
195_N199_N0.8151.00
155_I162_G0.8131.00
46_S50_L0.8131.00
337_G341_T0.8091.00
105_S247_G0.8041.00
264_R267_L0.8041.00
183_S191_K0.8031.00
324_M362_Q0.8021.00
189_L318_I0.7981.00
53_I171_K0.7961.00
321_V376_S0.7941.00
377_F383_I0.7931.00
197_I314_T0.7891.00
15_A289_G0.7851.00
83_R340_I0.7821.00
88_V91_M0.7791.00
142_D150_F0.7781.00
18_E293_A0.7771.00
15_A293_A0.7711.00
263_L291_I0.7711.00
383_I388_I0.7711.00
57_S171_K0.7691.00
102_G114_N0.7681.00
245_I276_I0.7671.00
263_L295_N0.7671.00
193_V318_I0.7661.00
252_N278_G0.7651.00
96_G99_V0.7631.00
361_A379_I0.7621.00
123_V269_N0.7611.00
257_V272_A0.7611.00
133_V237_M0.7571.00
51_H54_H0.7511.00
253_H256_F0.7511.00
377_F391_Y0.7501.00
345_I366_K0.7451.00
166_G206_V0.7421.00
141_E146_L0.7401.00
308_I312_V0.7391.00
385_V389_K0.7351.00
375_I379_I0.7341.00
58_E61_K0.7341.00
5_V16_S0.7341.00
138_I141_E0.7331.00
90_Y93_E0.7311.00
154_I235_V0.7311.00
284_E308_I0.7301.00
146_L234_V0.7241.00
353_I385_V0.7231.00
265_T272_A0.7211.00
186_L197_I0.7211.00
32_E101_H0.7201.00
60_E65_N0.7201.00
78_Q145_Y0.7171.00
177_V230_L0.7171.00
201_F208_L0.7161.00
5_V12_G0.7151.00
335_E339_A0.7131.00
140_S146_L0.7111.00
256_F280_H0.7111.00
3_I293_A0.7091.00
377_F388_I0.7071.00
196_A348_F0.7071.00
6_I248_F0.7071.00
61_K343_K0.7061.00
287_Y290_K0.7051.00
377_F381_Y0.7021.00
30_K33_R0.7011.00
273_A289_G0.6991.00
160_V312_V0.6991.00
307_G380_R0.6991.00
337_G340_I0.6981.00
387_E390_D0.6971.00
100_I104_A0.6971.00
288_A305_K0.6961.00
180_D187_P0.6931.00
127_T248_F0.6921.00
141_E145_Y0.6921.00
139_Y143_L0.6911.00
75_K147_N0.6871.00
353_I356_D0.6871.00
363_A371_V0.6821.00
361_A372_I0.6821.00
33_R41_Y0.6811.00
29_E113_V0.6811.00
287_Y303_F0.6791.00
365_M368_A0.6791.00
129_T241_R0.6771.00
138_I144_P0.6751.00
271_F296_I0.6741.00
33_R85_S0.6721.00
171_K315_H0.6721.00
370_E399_I0.6691.00
15_A292_A0.6691.00
165_F236_Y0.6691.00
353_I358_I0.6691.00
162_G181_K0.6681.00
380_R391_Y0.6671.00
168_M172_L0.6661.00
174_K233_D0.6661.00
355_D382_N0.6651.00
284_E288_A0.6651.00
181_K187_P0.6611.00
193_V196_A0.6601.00
98_E101_H0.6601.00
231_T234_V0.6571.00
138_I145_Y0.6571.00
72_E76_L0.6541.00
217_M237_M0.6521.00
20_A26_V0.6521.00
330_K350_K0.6511.00
167_W171_K0.6511.00
324_M352_C0.6501.00
43_C47_K0.6491.00
181_K239_F0.6481.00
307_G376_S0.6471.00
251_I257_V0.6471.00
49_M74_R0.6471.00
329_V332_N0.6411.00
22_N299_G0.6401.00
17_L21_K0.6401.00
55_L62_L0.6401.00
68_F73_L0.6381.00
86_K90_Y0.6381.00
140_S150_F0.6361.00
96_G104_A0.6361.00
323_S359_V0.6351.00
81_S84_L0.6351.00
19_L26_V0.6351.00
63_G72_E0.6321.00
377_F393_A0.6321.00
179_V232_A0.6311.00
245_I248_F0.6311.00
152_S170_R0.6291.00
138_I149_D0.6281.00
376_S380_R0.6271.00
110_Q269_N0.6271.00
315_H366_K0.6261.00
194_S198_T0.6261.00
344_E366_K0.6231.00
47_K50_L0.6211.00
20_A97_V0.6201.00
333_L401_A0.6191.00
277_I288_A0.6171.00
139_Y145_Y0.6150.99
155_I166_G0.6150.99
336_L341_T0.6150.99
185_L194_S0.6130.99
374_L399_I0.6130.99
323_S360_G0.6110.99
46_S165_F0.6110.99
82_Y85_S0.6110.99
363_A372_I0.6090.99
165_F168_M0.6080.99
77_G145_Y0.6070.99
163_V208_L0.6070.99
78_Q81_S0.6070.99
204_I315_H0.6060.99
87_G90_Y0.6040.99
209_Y224_L0.6020.99
395_H400_E0.6010.99
331_I335_E0.6010.99
333_L336_L0.5980.99
59_L66_I0.5980.99
294_T298_G0.5980.99
74_R147_N0.5970.99
245_I256_F0.5970.99
79_D82_Y0.5950.99
11_A126_A0.5950.99
311_V319_A0.5940.99
250_E255_P0.5930.99
113_V118_I0.5920.99
144_P150_F0.5920.99
361_A402_L0.5900.99
50_L54_H0.5890.99
167_W201_F0.5890.99
21_K95_N0.5890.99
71_G74_R0.5890.99
160_V310_K0.5880.99
320_Y327_K0.5870.99
290_K294_T0.5860.99
186_L312_V0.5850.99
94_D104_A0.5850.99
75_K78_Q0.5840.99
106_L269_N0.5840.99
167_W204_I0.5830.99
73_L172_L0.5820.99
124_V293_A0.5800.99
340_I345_I0.5790.99
162_G238_T0.5790.99
27_L98_E0.5790.99
137_I237_M0.5770.99
53_I56_A0.5770.99
257_V265_T0.5770.99
386_N390_D0.5760.99
76_L80_A0.5740.99
163_V185_L0.5730.99
99_V104_A0.5720.99
317_T398_Y0.5690.99
189_L312_V0.5690.99
146_L169_L0.5690.99
329_V353_I0.5680.99
35_G39_V0.5670.99
139_Y144_P0.5670.99
320_Y362_Q0.5650.99
294_T300_K0.5630.99
5_V26_V0.5620.99
153_V176_V0.5620.99
191_K194_S0.5610.99
142_D146_L0.5600.99
51_H58_E0.5600.99
376_S391_Y0.5590.99
55_L59_L0.5580.99
323_S352_C0.5580.99
351_L358_I0.5570.99
305_K308_I0.5560.99
273_A296_I0.5560.99
80_A83_R0.5550.99
246_Q249_E0.5550.99
15_A19_L0.5540.99
95_N104_A0.5520.99
291_I301_K0.5520.99
70_L73_L0.5510.99
91_M94_D0.5500.99
126_A273_A0.5460.99
250_E253_H0.5450.99
131_R139_Y0.5430.99
87_G92_L0.5430.99
335_E338_R0.5420.99
146_L149_D0.5410.99
331_I336_L0.5380.99
287_Y403_T0.5380.99
125_L248_F0.5380.99
35_G38_C0.5360.99
134_V214_V0.5360.99
33_R40_L0.5350.99
379_I383_I0.5340.99
334_V338_R0.5340.99
20_A25_V0.5340.99
333_L398_Y0.5320.99
169_L174_K0.5320.99
106_L248_F0.5320.99
8_S30_K0.5310.99
371_V398_Y0.5300.99
36_G39_V0.5290.98
212_R230_L0.5270.98
212_R215_K0.5270.98
286_M403_T0.5250.98
98_E104_A0.5250.98
251_I258_I0.5240.98
372_I394_P0.5240.98
115_N118_I0.5230.98
81_S85_S0.5210.98
48_A80_A0.5210.98
111_L119_Q0.5210.98
44_I47_K0.5170.98
334_V339_A0.5170.98
287_Y291_I0.5170.98
19_L297_M0.5170.98
207_R210_L0.5170.98
339_A398_Y0.5150.98
295_N302_V0.5150.98
347_G363_A0.5130.98
331_I334_V0.5130.98
147_N150_F0.5130.98
357_K379_I0.5130.98
142_D149_D0.5120.98
35_G45_P0.5110.98
342_E398_Y0.5110.98
71_G148_K0.5100.98
110_Q267_L0.5090.98
139_Y146_L0.5090.98
336_L340_I0.5080.98
214_V222_V0.5080.98
70_L149_D0.5080.98
99_V102_G0.5070.98
133_V239_F0.5070.98
338_R342_E0.5070.98
362_Q375_I0.5050.98
19_L296_I0.5050.98
329_V333_L0.5040.98
76_L343_K0.5030.98
330_K333_L0.5030.98
307_G321_V0.5020.98
109_G268_S0.5010.98
167_W315_H0.5010.98
39_V43_C0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 1 100 0.225 Contact Map
1zmdA 4 1 100 0.232 Contact Map
3ladA 2 1 100 0.234 Contact Map
3urhA 2 1 100 0.235 Contact Map
1lvlA 2 0.9976 100 0.235 Contact Map
1xdiA 3 0.9951 100 0.239 Contact Map
3ic9A 2 0.9976 100 0.24 Contact Map
3dk9A 2 0.9927 100 0.24 Contact Map
1v59A 2 1 100 0.24 Contact Map
3o0hA 2 0.9976 100 0.244 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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