GREMLIN Database
Q97VQ0 - Transposase ISC1217
UniProt: Q97VQ0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 354 (296)
Sequences: 1045 (797)
Seq/√Len: 46.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_I179_L4.0131.00
189_F205_G3.9201.00
89_V172_L3.2521.00
145_I178_S3.1691.00
36_L303_F3.0741.00
287_L307_K3.0021.00
224_E228_G2.9321.00
87_L179_L2.8111.00
91_D192_W2.8011.00
166_K174_E2.7551.00
155_E158_R2.5891.00
222_V228_G2.5131.00
143_H178_S2.5081.00
90_D274_R2.5081.00
223_S228_G2.4961.00
89_V187_K2.4581.00
90_D278_E2.4041.00
142_I182_L2.2981.00
220_V223_S2.2751.00
222_V226_P2.2641.00
128_V281_I2.2581.00
127_L193_Y2.2531.00
221_P226_P2.2411.00
221_P227_Q2.2361.00
204_V271_W2.2291.00
274_R278_E2.1651.00
88_I132_K2.1341.00
26_T30_K2.1151.00
224_E227_Q1.9750.99
143_H175_F1.9570.99
150_R154_E1.9550.99
278_E285_K1.9250.99
228_G232_V1.8580.99
91_D168_K1.8340.99
220_V226_P1.8290.99
91_D193_Y1.8250.99
145_I174_E1.8230.99
130_G139_I1.8160.99
222_V227_Q1.7750.99
293_S299_R1.7580.98
22_I30_K1.6750.98
32_V59_T1.6620.98
275_W278_E1.6590.98
240_K244_I1.6560.98
222_V229_E1.6550.98
85_V131_V1.6390.97
90_D285_K1.6380.97
62_N65_D1.6190.97
145_I301_S1.6150.97
95_H117_H1.5970.97
294_F299_R1.5870.97
22_I25_M1.5810.97
221_P224_E1.5640.97
220_V229_E1.5190.96
240_K243_V1.5150.96
220_V227_Q1.5100.96
160_G163_V1.4940.96
168_K193_Y1.4910.96
110_Q151_K1.4840.95
91_D275_W1.4810.95
98_Y101_A1.4730.95
211_A256_F1.4590.95
220_V228_G1.4460.95
221_P228_G1.4450.95
194_V205_G1.4310.94
193_Y285_K1.4310.94
223_S227_Q1.4280.94
93_H121_E1.4260.94
93_H114_C1.4180.94
194_V200_Q1.4080.94
279_V283_E1.3970.94
193_Y274_R1.3860.93
274_R285_K1.3820.93
296_T307_K1.3810.93
63_N292_G1.3810.93
86_L270_T1.3510.92
92_T278_E1.3500.92
114_C121_E1.3460.92
170_D173_L1.3410.92
89_V129_I1.3400.92
101_A124_I1.3380.92
221_P229_E1.3340.92
221_P225_F1.3330.92
102_M300_N1.3310.92
64_L306_L1.3280.92
295_L303_F1.3180.92
147_Y165_F1.3080.91
130_G281_I1.2990.91
243_V246_D1.2920.91
129_I175_F1.2850.90
228_G231_L1.2670.90
90_D275_W1.2540.89
70_A74_E1.2480.89
292_G300_N1.2470.89
275_W285_K1.2410.89
96_K109_A1.2380.89
29_R67_A1.2340.89
202_N258_T1.2280.88
223_S230_Y1.2280.88
240_K245_D1.2220.88
24_S71_K1.2200.88
231_L234_Y1.2090.88
297_W301_S1.2080.88
303_F310_S1.2050.87
159_R163_V1.2040.87
109_A122_P1.2030.87
211_A254_Y1.1990.87
195_N210_S1.1930.87
188_V270_T1.1870.87
77_K182_L1.1870.87
242_L267_I1.1870.87
226_P229_E1.1820.86
112_F115_R1.1790.86
206_E253_R1.1790.86
108_G148_I1.1680.86
37_L309_L1.1660.86
203_T258_T1.1650.86
191_S208_K1.1630.85
220_V224_E1.1520.85
130_G280_L1.1490.85
83_H156_L1.1490.85
304_V307_K1.1490.85
240_K257_S1.1440.84
223_S232_V1.1430.84
115_R192_W1.1360.84
190_D278_E1.1290.84
204_V257_S1.1210.83
152_V158_R1.1210.83
63_N67_A1.1100.83
26_T29_R1.1090.83
139_I276_D1.0940.82
93_H112_F1.0920.82
276_D311_L1.0880.81
22_I29_R1.0810.81
275_W314_V1.0800.81
90_D277_I1.0750.81
25_M29_R1.0750.81
19_N23_L1.0740.80
189_F194_V1.0510.79
101_A292_G1.0460.79
145_I171_A1.0390.78
21_V25_M1.0370.78
227_Q231_L1.0340.78
20_E25_M1.0340.78
94_D126_L1.0310.78
225_F228_G1.0280.77
186_S270_T1.0280.77
225_F232_V1.0170.77
86_L188_V1.0140.77
28_T33_A1.0120.76
224_E229_E1.0100.76
88_I188_V0.9980.75
38_L41_V0.9940.75
114_C125_Q0.9940.75
125_Q168_K0.9870.75
260_L263_T0.9830.74
277_I285_K0.9780.74
141_V312_L0.9760.74
90_D168_K0.9760.74
92_T275_W0.9710.73
285_K314_V0.9690.73
219_S267_I0.9690.73
162_E219_S0.9670.73
224_E230_Y0.9660.73
124_I300_N0.9610.73
127_L172_L0.9610.73
21_V27_G0.9600.72
274_R281_I0.9580.72
139_I280_L0.9480.72
207_L214_V0.9460.71
48_E51_Q0.9450.71
94_D101_A0.9450.71
299_R303_F0.9380.71
21_V24_S0.9350.70
36_L40_A0.9340.70
27_G31_D0.9320.70
249_G257_S0.9220.69
99_A176_L0.9220.69
246_D249_G0.9210.69
48_E293_S0.9190.69
128_V141_V0.9180.69
127_L171_A0.9170.69
167_T170_D0.9150.69
141_V280_L0.9130.69
33_A36_L0.9130.69
98_Y295_L0.9080.68
43_G142_I0.9060.68
126_L300_N0.9010.68
126_L304_V0.8970.67
33_A37_L0.8940.67
207_L278_E0.8920.67
32_V35_R0.8920.67
40_A45_N0.8910.67
239_I243_V0.8880.66
255_F271_W0.8870.66
148_I152_V0.8870.66
171_A175_F0.8860.66
68_A302_G0.8800.66
306_L310_S0.8760.65
227_Q232_V0.8760.65
223_S226_P0.8750.65
69_Q302_G0.8730.65
141_V311_L0.8650.64
112_F124_I0.8630.64
199_L205_G0.8630.64
112_F121_E0.8600.64
28_T36_L0.8560.64
28_T31_D0.8520.63
220_V232_V0.8510.63
281_I285_K0.8440.62
57_Y61_L0.8410.62
244_I247_Y0.8320.61
18_V34_K0.8320.61
257_S293_S0.8320.61
92_T274_R0.8310.61
114_C120_F0.8300.61
117_H121_E0.8300.61
91_D277_I0.8280.61
115_R121_E0.8210.60
71_K74_E0.8210.60
230_Y233_E0.8190.60
156_L163_V0.8160.60
135_V138_Q0.8150.60
193_Y275_W0.8100.59
114_C117_H0.7970.58
108_G288_G0.7960.58
205_G256_F0.7950.58
92_T289_L0.7920.58
91_D281_I0.7870.57
127_L145_I0.7840.57
45_N118_K0.7840.57
76_V223_S0.7820.57
94_D128_V0.7810.56
207_L256_F0.7760.56
58_E62_N0.7750.56
189_F192_W0.7740.56
70_A178_S0.7740.56
17_A20_E0.7710.56
102_M297_W0.7670.55
76_V80_V0.7660.55
29_R33_A0.7650.55
94_D304_V0.7630.55
62_N67_A0.7620.55
278_E281_I0.7620.55
147_Y168_K0.7610.55
40_A284_L0.7610.55
196_S290_E0.7600.54
40_A303_F0.7600.54
281_I284_L0.7590.54
90_D193_Y0.7580.54
34_K38_L0.7580.54
71_K75_V0.7550.54
153_E178_S0.7550.54
18_V37_L0.7510.54
155_E159_R0.7510.54
159_R162_E0.7510.54
112_F149_P0.7490.53
92_T285_K0.7470.53
191_S207_L0.7460.53
220_V225_F0.7460.53
241_L254_Y0.7460.53
69_Q305_A0.7420.53
239_I242_L0.7410.53
21_V182_L0.7400.52
72_L76_V0.7400.52
46_A293_S0.7370.52
40_A306_L0.7320.52
73_I77_K0.7320.52
166_K177_S0.7320.52
129_I187_K0.7310.52
114_C275_W0.7300.51
111_I120_F0.7290.51
118_K152_V0.7290.51
279_V282_R0.7270.51
18_V21_V0.7270.51
127_L168_K0.7260.51
23_L30_K0.7200.51
132_K273_N0.7160.50
190_D274_R0.7140.50
111_I122_P0.7140.50
39_G49_I0.7140.50
98_Y109_A0.7130.50
168_K192_W0.7130.50
278_E314_V0.7120.50
181_G185_K0.7110.50
124_I148_I0.7090.49
222_V234_Y0.7050.49
295_L310_S0.7050.49
154_E162_E0.7040.49
63_N69_Q0.7010.49
44_R291_G0.7000.49
277_I287_L0.6960.48
192_W275_W0.6920.48
271_W274_R0.6880.47
72_L75_V0.6880.47
154_E157_K0.6870.47
155_E167_T0.6850.47
36_L293_S0.6850.47
120_F308_A0.6850.47
29_R296_T0.6830.47
32_V63_N0.6830.47
90_D190_D0.6820.47
129_I176_L0.6770.46
69_Q306_L0.6760.46
263_T266_D0.6740.46
225_F235_L0.6740.46
182_L278_E0.6730.46
255_F310_S0.6710.46
64_L302_G0.6700.46
39_G60_V0.6700.46
17_A21_V0.6690.45
207_L211_A0.6680.45
93_H120_F0.6670.45
199_L203_T0.6670.45
193_Y278_E0.6660.45
67_A302_G0.6620.45
284_L289_L0.6610.45
18_V33_A0.6590.45
300_N304_V0.6590.45
98_Y102_M0.6580.44
189_F208_K0.6560.44
26_T32_V0.6550.44
76_V308_A0.6550.44
298_V302_G0.6540.44
111_I121_E0.6530.44
155_E309_L0.6500.44
150_R187_K0.6470.43
94_D303_F0.6460.43
91_D191_S0.6450.43
127_L274_R0.6350.42
194_V266_D0.6320.42
97_L121_E0.6320.42
80_V140_Y0.6310.42
43_G46_A0.6270.41
38_L157_K0.6240.41
82_D136_N0.6240.41
275_W281_I0.6230.41
95_H121_E0.6230.41
48_E283_E0.6190.41
179_L188_V0.6170.40
46_A195_N0.6150.40
111_I253_R0.6140.40
99_A109_A0.6140.40
208_K212_R0.6130.40
22_I27_G0.6120.40
122_P149_P0.6100.40
81_G207_L0.6050.39
95_H114_C0.6040.39
93_H125_Q0.6020.39
58_E292_G0.5990.39
75_V80_V0.5980.39
168_K274_R0.5970.39
74_E210_S0.5970.39
101_A303_F0.5940.38
239_I248_K0.5920.38
83_H233_E0.5920.38
31_D150_R0.5920.38
102_M124_I0.5910.38
26_T33_A0.5910.38
148_I159_R0.5880.38
72_L80_V0.5870.38
169_I177_S0.5860.38
257_S267_I0.5850.37
289_L304_V0.5820.37
113_Y183_N0.5820.37
127_L289_L0.5810.37
17_A31_D0.5810.37
294_F310_S0.5810.37
92_T304_V0.5800.37
22_I26_T0.5800.37
224_E231_L0.5790.37
89_V223_S0.5780.37
227_Q233_E0.5760.37
39_G200_Q0.5750.37
222_V225_F0.5730.36
83_H157_K0.5720.36
127_L147_Y0.5720.36
37_L142_I0.5710.36
190_D285_K0.5700.36
221_P231_L0.5690.36
114_C271_W0.5640.36
241_L251_G0.5640.36
54_E67_A0.5620.35
21_V213_V0.5620.35
76_V79_L0.5620.35
18_V22_I0.5600.35
172_L194_V0.5590.35
57_Y275_W0.5580.35
69_Q98_Y0.5550.35
74_E265_E0.5510.34
82_D85_V0.5490.34
124_I152_V0.5460.34
76_V142_I0.5450.34
192_W208_K0.5450.34
112_F125_Q0.5400.33
115_R275_W0.5400.33
111_I118_K0.5390.33
153_E181_G0.5390.33
168_K278_E0.5380.33
44_R50_A0.5380.33
87_L111_I0.5380.33
200_Q205_G0.5380.33
62_N299_R0.5360.33
266_D270_T0.5360.33
292_G303_F0.5340.33
17_A313_V0.5340.33
89_V175_F0.5330.33
89_V193_Y0.5320.33
45_N101_A0.5310.33
101_A295_L0.5310.33
233_E237_T0.5310.33
29_R32_V0.5310.33
172_L187_K0.5300.33
101_A305_A0.5300.33
29_R58_E0.5290.32
100_R154_E0.5290.32
45_N50_A0.5270.32
166_K207_L0.5260.32
214_V219_S0.5250.32
25_M30_K0.5250.32
115_R120_F0.5230.32
252_R309_L0.5200.32
65_D299_R0.5190.32
17_A32_V0.5190.32
101_A146_A0.5180.31
88_I276_D0.5150.31
296_T308_A0.5140.31
153_E156_L0.5140.31
199_L256_F0.5130.31
173_L237_T0.5120.31
32_V62_N0.5110.31
225_F233_E0.5110.31
75_V79_L0.5100.31
19_N27_G0.5100.31
316_Y322_G0.5100.31
45_N311_L0.5090.31
36_L48_E0.5090.31
82_D185_K0.5080.31
19_N34_K0.5080.31
197_R212_R0.5070.31
184_V282_R0.5050.30
50_A312_L0.5030.30
282_R285_K0.5010.30
31_D68_A0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9294 99.9 0.724 Contact Map
2j49A 1 0.2288 16.4 0.966 Contact Map
2kkoA 2 0.3023 12.9 0.967 Contact Map
3rqiA 2 0.1723 8.5 0.97 Contact Map
1qgpA 1 0.2034 7.6 0.971 Contact Map
3qfiA 1 0.2571 6.6 0.971 Contact Map
3owqA 1 0.226 6.3 0.972 Contact Map
2zkzA 2 0.2514 6 0.972 Contact Map
2nxpA 1 0.2345 5.9 0.972 Contact Map
3cuoA 2 0.2768 5.4 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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