Q97VQ0 - SULSO - GREMLIN Contacts

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Q97VQ0 - Transposase ISC1217

UniProt:	Q97VQ0	Sequences: MTKELTREEYYKALEKAVNEVILSMTGTRKDVAKRLLLGAVVGRNATEIAQEAEMDYETVLNNLDKAAQAKLIEVVKKLVGDHPVLLIVDDTHDHKLYARAMPVSRNGAQIFYCRAHKRFEPAIQLLVIGVKDLVNNQIYVIHIIAYIPRKVEEELKRRGEEVKFKTKIDALLEFLSSLSGLNVKSKVFDSWYVNSRTLQGNTVGELKSSARVVEGGRSVPVSEFPQGEYLVEYLGTPIKLLVIDDYKGYGRRYFFSTDLNDTAEDIITTWENRWDIEVLIRELKALGLEGGSFLTWVRNSGFVALKALSLLVVQYFKYSTGLMLGAKRLARLIKSIYREAGGIKKLFKRRRKP	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	354 (296)
Sequences:	1045 (797)
Seq/√Len:	46.3

SULSO - Q97VQ0 Q7LYK0 Q7LX51 Q97ZD8 Q97Y34 Q97XR1 Q97XK5 Q97YE4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_I	179_L	4.013	1.00
189_F	205_G	3.920	1.00
89_V	172_L	3.252	1.00
145_I	178_S	3.169	1.00
36_L	303_F	3.074	1.00
287_L	307_K	3.002	1.00
224_E	228_G	2.932	1.00
87_L	179_L	2.811	1.00
91_D	192_W	2.801	1.00
166_K	174_E	2.755	1.00
155_E	158_R	2.589	1.00
222_V	228_G	2.513	1.00
143_H	178_S	2.508	1.00
90_D	274_R	2.508	1.00
223_S	228_G	2.496	1.00
89_V	187_K	2.458	1.00
90_D	278_E	2.404	1.00
142_I	182_L	2.298	1.00
220_V	223_S	2.275	1.00
222_V	226_P	2.264	1.00
128_V	281_I	2.258	1.00
127_L	193_Y	2.253	1.00
221_P	226_P	2.241	1.00
221_P	227_Q	2.236	1.00
204_V	271_W	2.229	1.00
274_R	278_E	2.165	1.00
88_I	132_K	2.134	1.00
26_T	30_K	2.115	1.00
224_E	227_Q	1.975	0.99
143_H	175_F	1.957	0.99
150_R	154_E	1.955	0.99
278_E	285_K	1.925	0.99
228_G	232_V	1.858	0.99
91_D	168_K	1.834	0.99
220_V	226_P	1.829	0.99
91_D	193_Y	1.825	0.99
145_I	174_E	1.823	0.99
130_G	139_I	1.816	0.99
222_V	227_Q	1.775	0.99
293_S	299_R	1.758	0.98
22_I	30_K	1.675	0.98
32_V	59_T	1.662	0.98
275_W	278_E	1.659	0.98
240_K	244_I	1.656	0.98
222_V	229_E	1.655	0.98
85_V	131_V	1.639	0.97
90_D	285_K	1.638	0.97
62_N	65_D	1.619	0.97
145_I	301_S	1.615	0.97
95_H	117_H	1.597	0.97
294_F	299_R	1.587	0.97
22_I	25_M	1.581	0.97
221_P	224_E	1.564	0.97
220_V	229_E	1.519	0.96
240_K	243_V	1.515	0.96
220_V	227_Q	1.510	0.96
160_G	163_V	1.494	0.96
168_K	193_Y	1.491	0.96
110_Q	151_K	1.484	0.95
91_D	275_W	1.481	0.95
98_Y	101_A	1.473	0.95
211_A	256_F	1.459	0.95
220_V	228_G	1.446	0.95
221_P	228_G	1.445	0.95
194_V	205_G	1.431	0.94
193_Y	285_K	1.431	0.94
223_S	227_Q	1.428	0.94
93_H	121_E	1.426	0.94
93_H	114_C	1.418	0.94
194_V	200_Q	1.408	0.94
279_V	283_E	1.397	0.94
193_Y	274_R	1.386	0.93
274_R	285_K	1.382	0.93
296_T	307_K	1.381	0.93
63_N	292_G	1.381	0.93
86_L	270_T	1.351	0.92
92_T	278_E	1.350	0.92
114_C	121_E	1.346	0.92
170_D	173_L	1.341	0.92
89_V	129_I	1.340	0.92
101_A	124_I	1.338	0.92
221_P	229_E	1.334	0.92
221_P	225_F	1.333	0.92
102_M	300_N	1.331	0.92
64_L	306_L	1.328	0.92
295_L	303_F	1.318	0.92
147_Y	165_F	1.308	0.91
130_G	281_I	1.299	0.91
243_V	246_D	1.292	0.91
129_I	175_F	1.285	0.90
228_G	231_L	1.267	0.90
90_D	275_W	1.254	0.89
70_A	74_E	1.248	0.89
292_G	300_N	1.247	0.89
275_W	285_K	1.241	0.89
96_K	109_A	1.238	0.89
29_R	67_A	1.234	0.89
202_N	258_T	1.228	0.88
223_S	230_Y	1.228	0.88
240_K	245_D	1.222	0.88
24_S	71_K	1.220	0.88
231_L	234_Y	1.209	0.88
297_W	301_S	1.208	0.88
303_F	310_S	1.205	0.87
159_R	163_V	1.204	0.87
109_A	122_P	1.203	0.87
211_A	254_Y	1.199	0.87
195_N	210_S	1.193	0.87
188_V	270_T	1.187	0.87
77_K	182_L	1.187	0.87
242_L	267_I	1.187	0.87
226_P	229_E	1.182	0.86
112_F	115_R	1.179	0.86
206_E	253_R	1.179	0.86
108_G	148_I	1.168	0.86
37_L	309_L	1.166	0.86
203_T	258_T	1.165	0.86
191_S	208_K	1.163	0.85
220_V	224_E	1.152	0.85
130_G	280_L	1.149	0.85
83_H	156_L	1.149	0.85
304_V	307_K	1.149	0.85
240_K	257_S	1.144	0.84
223_S	232_V	1.143	0.84
115_R	192_W	1.136	0.84
190_D	278_E	1.129	0.84
204_V	257_S	1.121	0.83
152_V	158_R	1.121	0.83
63_N	67_A	1.110	0.83
26_T	29_R	1.109	0.83
139_I	276_D	1.094	0.82
93_H	112_F	1.092	0.82
276_D	311_L	1.088	0.81
22_I	29_R	1.081	0.81
275_W	314_V	1.080	0.81
90_D	277_I	1.075	0.81
25_M	29_R	1.075	0.81
19_N	23_L	1.074	0.80
189_F	194_V	1.051	0.79
101_A	292_G	1.046	0.79
145_I	171_A	1.039	0.78
21_V	25_M	1.037	0.78
227_Q	231_L	1.034	0.78
20_E	25_M	1.034	0.78
94_D	126_L	1.031	0.78
225_F	228_G	1.028	0.77
186_S	270_T	1.028	0.77
225_F	232_V	1.017	0.77
86_L	188_V	1.014	0.77
28_T	33_A	1.012	0.76
224_E	229_E	1.010	0.76
88_I	188_V	0.998	0.75
38_L	41_V	0.994	0.75
114_C	125_Q	0.994	0.75
125_Q	168_K	0.987	0.75
260_L	263_T	0.983	0.74
277_I	285_K	0.978	0.74
141_V	312_L	0.976	0.74
90_D	168_K	0.976	0.74
92_T	275_W	0.971	0.73
285_K	314_V	0.969	0.73
219_S	267_I	0.969	0.73
162_E	219_S	0.967	0.73
224_E	230_Y	0.966	0.73
124_I	300_N	0.961	0.73
127_L	172_L	0.961	0.73
21_V	27_G	0.960	0.72
274_R	281_I	0.958	0.72
139_I	280_L	0.948	0.72
207_L	214_V	0.946	0.71
48_E	51_Q	0.945	0.71
94_D	101_A	0.945	0.71
299_R	303_F	0.938	0.71
21_V	24_S	0.935	0.70
36_L	40_A	0.934	0.70
27_G	31_D	0.932	0.70
249_G	257_S	0.922	0.69
99_A	176_L	0.922	0.69
246_D	249_G	0.921	0.69
48_E	293_S	0.919	0.69
128_V	141_V	0.918	0.69
127_L	171_A	0.917	0.69
167_T	170_D	0.915	0.69
141_V	280_L	0.913	0.69
33_A	36_L	0.913	0.69
98_Y	295_L	0.908	0.68
43_G	142_I	0.906	0.68
126_L	300_N	0.901	0.68
126_L	304_V	0.897	0.67
33_A	37_L	0.894	0.67
207_L	278_E	0.892	0.67
32_V	35_R	0.892	0.67
40_A	45_N	0.891	0.67
239_I	243_V	0.888	0.66
255_F	271_W	0.887	0.66
148_I	152_V	0.887	0.66
171_A	175_F	0.886	0.66
68_A	302_G	0.880	0.66
306_L	310_S	0.876	0.65
227_Q	232_V	0.876	0.65
223_S	226_P	0.875	0.65
69_Q	302_G	0.873	0.65
141_V	311_L	0.865	0.64
112_F	124_I	0.863	0.64
199_L	205_G	0.863	0.64
112_F	121_E	0.860	0.64
28_T	36_L	0.856	0.64
28_T	31_D	0.852	0.63
220_V	232_V	0.851	0.63
281_I	285_K	0.844	0.62
57_Y	61_L	0.841	0.62
244_I	247_Y	0.832	0.61
18_V	34_K	0.832	0.61
257_S	293_S	0.832	0.61
92_T	274_R	0.831	0.61
114_C	120_F	0.830	0.61
117_H	121_E	0.830	0.61
91_D	277_I	0.828	0.61
115_R	121_E	0.821	0.60
71_K	74_E	0.821	0.60
230_Y	233_E	0.819	0.60
156_L	163_V	0.816	0.60
135_V	138_Q	0.815	0.60
193_Y	275_W	0.810	0.59
114_C	117_H	0.797	0.58
108_G	288_G	0.796	0.58
205_G	256_F	0.795	0.58
92_T	289_L	0.792	0.58
91_D	281_I	0.787	0.57
127_L	145_I	0.784	0.57
45_N	118_K	0.784	0.57
76_V	223_S	0.782	0.57
94_D	128_V	0.781	0.56
207_L	256_F	0.776	0.56
58_E	62_N	0.775	0.56
189_F	192_W	0.774	0.56
70_A	178_S	0.774	0.56
17_A	20_E	0.771	0.56
102_M	297_W	0.767	0.55
76_V	80_V	0.766	0.55
29_R	33_A	0.765	0.55
94_D	304_V	0.763	0.55
62_N	67_A	0.762	0.55
278_E	281_I	0.762	0.55
147_Y	168_K	0.761	0.55
40_A	284_L	0.761	0.55
196_S	290_E	0.760	0.54
40_A	303_F	0.760	0.54
281_I	284_L	0.759	0.54
90_D	193_Y	0.758	0.54
34_K	38_L	0.758	0.54
71_K	75_V	0.755	0.54
153_E	178_S	0.755	0.54
18_V	37_L	0.751	0.54
155_E	159_R	0.751	0.54
159_R	162_E	0.751	0.54
112_F	149_P	0.749	0.53
92_T	285_K	0.747	0.53
191_S	207_L	0.746	0.53
220_V	225_F	0.746	0.53
241_L	254_Y	0.746	0.53
69_Q	305_A	0.742	0.53
239_I	242_L	0.741	0.53
21_V	182_L	0.740	0.52
72_L	76_V	0.740	0.52
46_A	293_S	0.737	0.52
40_A	306_L	0.732	0.52
73_I	77_K	0.732	0.52
166_K	177_S	0.732	0.52
129_I	187_K	0.731	0.52
114_C	275_W	0.730	0.51
111_I	120_F	0.729	0.51
118_K	152_V	0.729	0.51
279_V	282_R	0.727	0.51
18_V	21_V	0.727	0.51
127_L	168_K	0.726	0.51
23_L	30_K	0.720	0.51
132_K	273_N	0.716	0.50
190_D	274_R	0.714	0.50
111_I	122_P	0.714	0.50
39_G	49_I	0.714	0.50
98_Y	109_A	0.713	0.50
168_K	192_W	0.713	0.50
278_E	314_V	0.712	0.50
181_G	185_K	0.711	0.50
124_I	148_I	0.709	0.49
222_V	234_Y	0.705	0.49
295_L	310_S	0.705	0.49
154_E	162_E	0.704	0.49
63_N	69_Q	0.701	0.49
44_R	291_G	0.700	0.49
277_I	287_L	0.696	0.48
192_W	275_W	0.692	0.48
271_W	274_R	0.688	0.47
72_L	75_V	0.688	0.47
154_E	157_K	0.687	0.47
155_E	167_T	0.685	0.47
36_L	293_S	0.685	0.47
120_F	308_A	0.685	0.47
29_R	296_T	0.683	0.47
32_V	63_N	0.683	0.47
90_D	190_D	0.682	0.47
129_I	176_L	0.677	0.46
69_Q	306_L	0.676	0.46
263_T	266_D	0.674	0.46
225_F	235_L	0.674	0.46
182_L	278_E	0.673	0.46
255_F	310_S	0.671	0.46
64_L	302_G	0.670	0.46
39_G	60_V	0.670	0.46
17_A	21_V	0.669	0.45
207_L	211_A	0.668	0.45
93_H	120_F	0.667	0.45
199_L	203_T	0.667	0.45
193_Y	278_E	0.666	0.45
67_A	302_G	0.662	0.45
284_L	289_L	0.661	0.45
18_V	33_A	0.659	0.45
300_N	304_V	0.659	0.45
98_Y	102_M	0.658	0.44
189_F	208_K	0.656	0.44
26_T	32_V	0.655	0.44
76_V	308_A	0.655	0.44
298_V	302_G	0.654	0.44
111_I	121_E	0.653	0.44
155_E	309_L	0.650	0.44
150_R	187_K	0.647	0.43
94_D	303_F	0.646	0.43
91_D	191_S	0.645	0.43
127_L	274_R	0.635	0.42
194_V	266_D	0.632	0.42
97_L	121_E	0.632	0.42
80_V	140_Y	0.631	0.42
43_G	46_A	0.627	0.41
38_L	157_K	0.624	0.41
82_D	136_N	0.624	0.41
275_W	281_I	0.623	0.41
95_H	121_E	0.623	0.41
48_E	283_E	0.619	0.41
179_L	188_V	0.617	0.40
46_A	195_N	0.615	0.40
111_I	253_R	0.614	0.40
99_A	109_A	0.614	0.40
208_K	212_R	0.613	0.40
22_I	27_G	0.612	0.40
122_P	149_P	0.610	0.40
81_G	207_L	0.605	0.39
95_H	114_C	0.604	0.39
93_H	125_Q	0.602	0.39
58_E	292_G	0.599	0.39
75_V	80_V	0.598	0.39
168_K	274_R	0.597	0.39
74_E	210_S	0.597	0.39
101_A	303_F	0.594	0.38
239_I	248_K	0.592	0.38
83_H	233_E	0.592	0.38
31_D	150_R	0.592	0.38
102_M	124_I	0.591	0.38
26_T	33_A	0.591	0.38
148_I	159_R	0.588	0.38
72_L	80_V	0.587	0.38
169_I	177_S	0.586	0.38
257_S	267_I	0.585	0.37
289_L	304_V	0.582	0.37
113_Y	183_N	0.582	0.37
127_L	289_L	0.581	0.37
17_A	31_D	0.581	0.37
294_F	310_S	0.581	0.37
92_T	304_V	0.580	0.37
22_I	26_T	0.580	0.37
224_E	231_L	0.579	0.37
89_V	223_S	0.578	0.37
227_Q	233_E	0.576	0.37
39_G	200_Q	0.575	0.37
222_V	225_F	0.573	0.36
83_H	157_K	0.572	0.36
127_L	147_Y	0.572	0.36
37_L	142_I	0.571	0.36
190_D	285_K	0.570	0.36
221_P	231_L	0.569	0.36
114_C	271_W	0.564	0.36
241_L	251_G	0.564	0.36
54_E	67_A	0.562	0.35
21_V	213_V	0.562	0.35
76_V	79_L	0.562	0.35
18_V	22_I	0.560	0.35
172_L	194_V	0.559	0.35
57_Y	275_W	0.558	0.35
69_Q	98_Y	0.555	0.35
74_E	265_E	0.551	0.34
82_D	85_V	0.549	0.34
124_I	152_V	0.546	0.34
76_V	142_I	0.545	0.34
192_W	208_K	0.545	0.34
112_F	125_Q	0.540	0.33
115_R	275_W	0.540	0.33
111_I	118_K	0.539	0.33
153_E	181_G	0.539	0.33
168_K	278_E	0.538	0.33
44_R	50_A	0.538	0.33
87_L	111_I	0.538	0.33
200_Q	205_G	0.538	0.33
62_N	299_R	0.536	0.33
266_D	270_T	0.536	0.33
292_G	303_F	0.534	0.33
17_A	313_V	0.534	0.33
89_V	175_F	0.533	0.33
89_V	193_Y	0.532	0.33
45_N	101_A	0.531	0.33
101_A	295_L	0.531	0.33
233_E	237_T	0.531	0.33
29_R	32_V	0.531	0.33
172_L	187_K	0.530	0.33
101_A	305_A	0.530	0.33
29_R	58_E	0.529	0.32
100_R	154_E	0.529	0.32
45_N	50_A	0.527	0.32
166_K	207_L	0.526	0.32
214_V	219_S	0.525	0.32
25_M	30_K	0.525	0.32
115_R	120_F	0.523	0.32
252_R	309_L	0.520	0.32
65_D	299_R	0.519	0.32
17_A	32_V	0.519	0.32
101_A	146_A	0.518	0.31
88_I	276_D	0.515	0.31
296_T	308_A	0.514	0.31
153_E	156_L	0.514	0.31
199_L	256_F	0.513	0.31
173_L	237_T	0.512	0.31
32_V	62_N	0.511	0.31
225_F	233_E	0.511	0.31
75_V	79_L	0.510	0.31
19_N	27_G	0.510	0.31
316_Y	322_G	0.510	0.31
45_N	311_L	0.509	0.31
36_L	48_E	0.509	0.31
82_D	185_K	0.508	0.31
19_N	34_K	0.508	0.31
197_R	212_R	0.507	0.31
184_V	282_R	0.505	0.30
50_A	312_L	0.503	0.30
282_R	285_K	0.501	0.30
31_D	68_A	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.9294	99.9	0.724	Contact Map
2j49A	1	0.2288	16.4	0.966	Contact Map
2kkoA	2	0.3023	12.9	0.967	Contact Map
3rqiA	2	0.1723	8.5	0.97	Contact Map
1qgpA	1	0.2034	7.6	0.971	Contact Map
3qfiA	1	0.2571	6.6	0.971	Contact Map
3owqA	1	0.226	6.3	0.972	Contact Map
2zkzA	2	0.2514	6	0.972	Contact Map
2nxpA	1	0.2345	5.9	0.972	Contact Map
3cuoA	2	0.2768	5.4	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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