Q97VP8 - SULSO - GREMLIN Contacts

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Q97VP8 - Uncharacterized protein

UniProt:	Q97VP8	Sequences: MRKLENIILKNYEEELFDHEVYSKLAEVERDPELKKTLFKLAEMEKKHSEFWREIAEKRGLKVKGKLSTLNKIKVDFYSLLRKILGLDITIKVLESSEEDDIEKYRKLSEMEMFSSEEKQRLKDIMVDEAVHEKVLGNVEAKSVGDFVYGISDGLVEVLAAVSGLSGAISSPLFVAVGGLIVGVSGTLSMAIGAYLSTKSEKDVKIQERKRLELEKNVDQHSVQLRLVNFFTELGVNLNLAKKVSLSLVNVAEDILYPEVKENPVKSALITGLSYITGAIIPILPYLIGLSGLTGLITSYIVAGLSTFIVGSIIGILSGISPFKKGIQMASLALLAALGTHGLGYLASRFLNVSI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	355 (335)
Sequences:	330 (255)
Seq/√Len:	13.9

SULSO - Q97VP8 Q97TY3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
168_A	177_V	5.300	1.00
50_E	54_E	4.549	1.00
137_G	143_S	3.820	1.00
35_K	39_F	3.318	0.99
308_F	326_G	3.278	0.98
137_G	142_K	3.268	0.98
16_L	53_R	3.215	0.98
60_G	64_K	3.045	0.97
60_G	63_V	2.962	0.97
166_S	296_L	2.908	0.97
296_L	300_Y	2.637	0.94
191_A	299_S	2.557	0.93
19_H	40_K	2.499	0.92
321_S	324_K	2.465	0.92
281_I	339_G	2.463	0.92
49_S	53_R	2.458	0.92
320_I	324_K	2.385	0.90
191_A	339_G	2.331	0.89
163_S	300_Y	2.283	0.88
215_E	223_V	2.244	0.87
165_L	178_G	2.219	0.87
21_V	64_K	2.211	0.86
280_I	284_L	2.166	0.85
56_A	61_L	2.134	0.84
180_L	287_L	2.112	0.84
146_D	194_A	1.978	0.79
196_L	320_I	1.963	0.79
290_L	294_T	1.926	0.78
210_K	243_K	1.915	0.77
197_S	336_A	1.889	0.76
265_V	269_L	1.882	0.76
191_A	263_N	1.872	0.75
157_E	275_Y	1.839	0.74
45_E	48_H	1.780	0.72
162_V	283_I	1.777	0.71
295_G	321_S	1.777	0.71
166_S	286_Y	1.770	0.71
338_L	342_G	1.764	0.71
23_S	46_K	1.755	0.70
242_K	246_L	1.712	0.69
202_K	295_G	1.707	0.68
19_H	79_S	1.676	0.67
180_L	283_I	1.655	0.66
174_F	178_G	1.642	0.65
246_L	291_S	1.637	0.65
288_I	339_G	1.626	0.64
120_Q	123_K	1.617	0.64
132_H	136_L	1.590	0.63
304_G	334_L	1.589	0.63
300_Y	334_L	1.578	0.62
74_K	134_K	1.575	0.62
341_H	345_Y	1.575	0.62
146_D	328_Q	1.569	0.61
135_V	195_Y	1.568	0.61
61_L	64_K	1.567	0.61
156_V	186_G	1.559	0.61
196_L	201_E	1.548	0.60
243_K	247_S	1.537	0.60
48_H	98_E	1.535	0.60
146_D	275_Y	1.529	0.59
51_F	55_I	1.504	0.58
194_A	328_Q	1.499	0.58
309_I	312_S	1.487	0.57
212_L	254_D	1.485	0.57
149_Y	198_T	1.473	0.56
176_A	231_F	1.441	0.55
14_E	72_K	1.441	0.55
186_G	336_A	1.438	0.55
275_Y	307_T	1.437	0.55
342_G	346_L	1.432	0.54
96_S	181_I	1.430	0.54
102_I	180_L	1.420	0.54
148_V	276_I	1.417	0.53
199_K	202_K	1.415	0.53
290_L	298_T	1.413	0.53
292_G	295_G	1.409	0.53
30_R	41_L	1.408	0.53
191_A	277_T	1.406	0.53
231_F	312_S	1.403	0.53
294_T	298_T	1.399	0.52
186_G	307_T	1.398	0.52
5_E	58_K	1.392	0.52
131_V	231_F	1.386	0.52
194_A	267_S	1.381	0.52
177_V	238_L	1.377	0.51
259_E	339_G	1.376	0.51
291_S	346_L	1.364	0.51
9_L	13_E	1.361	0.50
116_S	120_Q	1.351	0.50
75_V	248_L	1.346	0.50
210_K	214_L	1.344	0.50
191_A	281_I	1.335	0.49
170_S	178_G	1.307	0.48
165_L	286_Y	1.295	0.47
5_E	99_E	1.292	0.47
51_F	113_M	1.291	0.47
294_T	297_I	1.289	0.47
72_K	301_I	1.285	0.46
215_E	253_E	1.284	0.46
59_R	312_S	1.282	0.46
194_A	271_T	1.281	0.46
177_V	242_K	1.276	0.46
166_S	175_V	1.274	0.46
150_G	190_M	1.272	0.46
48_H	91_I	1.271	0.46
146_D	272_G	1.264	0.45
211_R	240_L	1.263	0.45
217_N	248_L	1.261	0.45
162_V	175_V	1.258	0.45
224_Q	246_L	1.253	0.45
46_K	65_G	1.248	0.44
149_Y	192_I	1.247	0.44
17_F	20_E	1.243	0.44
307_T	336_A	1.240	0.44
271_T	328_Q	1.239	0.44
43_E	293_L	1.230	0.43
58_K	61_L	1.229	0.43
191_A	216_K	1.228	0.43
206_I	246_L	1.228	0.43
21_V	24_K	1.223	0.43
194_A	272_G	1.222	0.43
146_D	271_T	1.220	0.43
342_G	349_R	1.217	0.43
226_R	333_A	1.209	0.42
214_L	243_K	1.206	0.42
45_E	98_E	1.198	0.42
327_I	331_S	1.191	0.41
177_V	222_S	1.191	0.41
210_K	248_L	1.186	0.41
197_S	307_T	1.180	0.41
43_E	294_T	1.178	0.41
249_V	252_A	1.177	0.41
156_V	197_S	1.176	0.41
284_L	301_I	1.171	0.40
50_E	293_L	1.171	0.40
31_D	286_Y	1.162	0.40
272_G	275_Y	1.161	0.40
258_P	277_T	1.160	0.40
212_L	253_E	1.148	0.39
304_G	330_A	1.147	0.39
222_S	248_L	1.130	0.38
166_S	265_V	1.128	0.38
186_G	197_S	1.117	0.38
36_K	280_I	1.114	0.37
49_S	168_A	1.113	0.37
262_E	271_T	1.112	0.37
194_A	275_Y	1.104	0.37
14_E	181_I	1.103	0.37
157_E	182_V	1.101	0.37
148_V	314_I	1.099	0.37
90_T	199_K	1.097	0.37
149_Y	201_E	1.095	0.36
265_V	291_S	1.091	0.36
49_S	75_V	1.088	0.36
145_G	186_G	1.082	0.36
308_F	313_I	1.074	0.35
191_A	264_P	1.070	0.35
238_L	242_K	1.069	0.35
179_G	283_I	1.066	0.35
156_V	336_A	1.060	0.35
210_K	217_N	1.059	0.35
286_Y	334_L	1.059	0.35
55_I	191_A	1.057	0.35
116_S	123_K	1.055	0.34
185_S	206_I	1.048	0.34
14_E	162_V	1.046	0.34
46_K	191_A	1.046	0.34
51_F	110_E	1.043	0.34
11_N	168_A	1.039	0.34
165_L	168_A	1.037	0.34
118_E	121_R	1.036	0.34
273_L	313_I	1.035	0.33
145_G	198_T	1.033	0.33
9_L	287_L	1.033	0.33
133_E	136_L	1.030	0.33
95_E	132_H	1.027	0.33
211_R	217_N	1.027	0.33
169_I	318_S	1.024	0.33
59_R	242_K	1.013	0.32
257_Y	261_K	1.011	0.32
296_L	305_L	1.006	0.32
186_G	275_Y	1.004	0.32
212_L	249_V	1.002	0.32
5_E	64_K	1.001	0.32
116_S	122_L	1.000	0.32
117_E	343_L	0.998	0.32
239_N	339_G	0.997	0.32
102_I	283_I	0.996	0.32
286_Y	304_G	0.996	0.32
283_I	287_L	0.991	0.31
46_K	264_P	0.987	0.31
145_G	307_T	0.987	0.31
146_D	267_S	0.985	0.31
149_Y	307_T	0.976	0.31
223_V	253_E	0.973	0.31
158_V	194_A	0.971	0.30
80_L	281_I	0.966	0.30
198_T	201_E	0.966	0.30
85_L	89_I	0.966	0.30
11_N	108_L	0.964	0.30
35_K	77_F	0.964	0.30
263_N	274_S	0.953	0.30
20_E	75_V	0.942	0.29
180_L	331_S	0.934	0.29
197_S	275_Y	0.934	0.29
287_L	298_T	0.932	0.29
59_R	162_V	0.931	0.29
157_E	271_T	0.930	0.29
77_F	294_T	0.926	0.28
145_G	149_Y	0.924	0.28
271_T	275_Y	0.920	0.28
295_G	304_G	0.917	0.28
275_Y	336_A	0.915	0.28
79_S	121_R	0.912	0.28
113_M	116_S	0.911	0.28
91_I	229_N	0.910	0.28
149_Y	330_A	0.910	0.28
311_G	326_G	0.904	0.27
80_L	84_I	0.899	0.27
286_Y	349_R	0.899	0.27
27_E	61_L	0.897	0.27
111_M	269_L	0.895	0.27
104_K	283_I	0.893	0.27
159_L	303_A	0.891	0.27
27_E	43_E	0.890	0.27
119_K	126_M	0.888	0.27
54_E	263_N	0.886	0.27
116_S	127_V	0.884	0.27
292_G	296_L	0.882	0.27
206_I	242_K	0.878	0.26
29_E	41_L	0.873	0.26
5_E	61_L	0.873	0.26
186_G	268_A	0.871	0.26
27_E	206_I	0.868	0.26
91_I	98_E	0.867	0.26
214_L	228_V	0.864	0.26
157_E	186_G	0.864	0.26
148_V	274_S	0.863	0.26
14_E	90_T	0.863	0.26
179_G	299_S	0.861	0.26
50_E	53_R	0.860	0.26
77_F	246_L	0.856	0.25
72_K	250_N	0.855	0.25
97_S	297_I	0.851	0.25
80_L	134_K	0.845	0.25
21_V	90_T	0.836	0.25
78_Y	148_V	0.835	0.25
41_L	118_E	0.835	0.25
156_V	275_Y	0.831	0.24
228_V	242_K	0.828	0.24
5_E	59_R	0.827	0.24
93_V	195_Y	0.826	0.24
158_V	328_Q	0.825	0.24
277_T	345_Y	0.817	0.24
161_A	194_A	0.816	0.24
244_V	248_L	0.813	0.24
12_Y	16_L	0.811	0.24
223_V	254_D	0.810	0.24
158_V	183_G	0.809	0.24
252_A	298_T	0.802	0.23
167_G	286_Y	0.801	0.23
25_L	98_E	0.801	0.23
118_E	123_K	0.801	0.23
64_K	331_S	0.799	0.23
91_I	125_I	0.799	0.23
322_P	330_A	0.799	0.23
156_V	194_A	0.797	0.23
204_V	328_Q	0.794	0.23
162_V	299_S	0.793	0.23
249_V	253_E	0.792	0.23
23_S	248_L	0.792	0.23
191_A	267_S	0.788	0.23
263_N	331_S	0.788	0.23
84_I	283_I	0.786	0.23
166_S	199_K	0.781	0.22
214_L	280_I	0.780	0.22
231_F	295_G	0.780	0.22
108_L	222_S	0.775	0.22
133_E	334_L	0.775	0.22
180_L	238_L	0.772	0.22
158_V	279_A	0.772	0.22
192_I	201_E	0.772	0.22
156_V	198_T	0.772	0.22
198_T	307_T	0.770	0.22
243_K	286_Y	0.767	0.22
37_T	42_A	0.764	0.22
239_N	316_I	0.763	0.22
258_P	266_K	0.762	0.22
191_A	260_V	0.762	0.22
248_L	302_V	0.761	0.22
118_E	281_I	0.759	0.22
144_V	303_A	0.758	0.22
231_F	275_Y	0.752	0.21
274_S	277_T	0.750	0.21
137_G	283_I	0.749	0.21
55_I	148_V	0.742	0.21
145_G	197_S	0.737	0.21
72_K	249_V	0.736	0.21
146_D	158_V	0.734	0.21
167_G	177_V	0.733	0.21
110_E	113_M	0.732	0.21
183_G	194_A	0.730	0.21
75_V	168_A	0.730	0.21
157_E	307_T	0.730	0.21
115_S	122_L	0.729	0.21
167_G	334_L	0.728	0.21
178_G	191_A	0.724	0.20
157_E	194_A	0.724	0.20
74_K	254_D	0.720	0.20
273_L	305_L	0.720	0.20
145_G	319_G	0.719	0.20
126_M	130_A	0.717	0.20
160_A	230_F	0.714	0.20
63_V	236_V	0.713	0.20
44_M	175_V	0.706	0.20
10_K	250_N	0.703	0.20
177_V	181_I	0.699	0.20
200_S	205_K	0.696	0.19
122_L	125_I	0.695	0.19
157_E	197_S	0.694	0.19
288_I	341_H	0.693	0.19
40_K	338_L	0.691	0.19
146_D	157_E	0.691	0.19
54_E	111_M	0.687	0.19
183_G	275_Y	0.685	0.19
275_Y	328_Q	0.684	0.19
33_E	58_K	0.683	0.19
248_L	281_I	0.682	0.19
212_L	264_P	0.681	0.19
180_L	276_I	0.677	0.19
249_V	346_L	0.675	0.19
54_E	73_I	0.675	0.19
204_V	272_G	0.671	0.19
74_K	263_N	0.670	0.19
304_G	308_F	0.667	0.18
105_Y	212_L	0.667	0.18
74_K	250_N	0.664	0.18
184_V	315_G	0.663	0.18
223_V	239_N	0.662	0.18
161_A	182_V	0.659	0.18
78_Y	90_T	0.659	0.18
273_L	277_T	0.654	0.18
186_G	271_T	0.653	0.18
46_K	73_I	0.652	0.18
156_V	307_T	0.652	0.18
17_F	49_S	0.652	0.18
243_K	313_I	0.651	0.18
165_L	283_I	0.650	0.18
121_R	210_K	0.650	0.18
199_K	296_L	0.649	0.18
152_S	182_V	0.649	0.18
211_R	244_V	0.647	0.18
258_P	274_S	0.646	0.18
206_I	237_N	0.645	0.18
161_A	271_T	0.644	0.18
163_S	326_G	0.644	0.18
90_T	277_T	0.642	0.18
148_V	301_I	0.641	0.18
58_K	251_V	0.640	0.18
24_K	83_K	0.639	0.18
162_V	339_G	0.638	0.18
145_G	152_S	0.637	0.18
172_P	293_L	0.635	0.17
75_V	217_N	0.632	0.17
90_T	181_I	0.631	0.17
57_E	60_G	0.630	0.17
186_G	193_G	0.630	0.17
51_F	101_D	0.630	0.17
157_E	272_G	0.626	0.17
200_S	318_S	0.625	0.17
173_L	177_V	0.625	0.17
31_D	258_P	0.623	0.17
187_T	307_T	0.623	0.17
145_G	336_A	0.622	0.17
254_D	288_I	0.621	0.17
318_S	322_P	0.620	0.17
117_E	123_K	0.617	0.17
35_K	242_K	0.616	0.17
165_L	316_I	0.615	0.17
299_S	316_I	0.614	0.17
85_L	345_Y	0.614	0.17
20_E	43_E	0.613	0.17
246_L	273_L	0.613	0.17
13_E	16_L	0.613	0.17
76_D	142_K	0.613	0.17
161_A	186_G	0.612	0.17
166_S	320_I	0.612	0.17
91_I	227_L	0.610	0.17
300_Y	309_I	0.610	0.17
19_H	349_R	0.610	0.17
90_T	283_I	0.609	0.17
250_N	301_I	0.609	0.17
143_S	201_E	0.608	0.17
8_I	12_Y	0.608	0.17
15_E	22_Y	0.607	0.17
182_V	271_T	0.607	0.17
211_R	326_G	0.607	0.17
202_K	256_L	0.605	0.17
241_A	245_S	0.604	0.17
14_E	41_L	0.603	0.16
19_H	49_S	0.603	0.16
20_E	53_R	0.602	0.16
183_G	262_E	0.601	0.16
243_K	248_L	0.601	0.16
267_S	272_G	0.598	0.16
129_E	215_E	0.598	0.16
259_E	302_V	0.595	0.16
64_K	88_D	0.592	0.16
283_I	286_Y	0.591	0.16
158_V	276_I	0.590	0.16
20_E	49_S	0.588	0.16
50_E	237_N	0.587	0.16
217_N	246_L	0.586	0.16
117_E	120_Q	0.585	0.16
78_Y	284_L	0.585	0.16
142_K	149_Y	0.585	0.16
16_L	30_R	0.584	0.16
54_E	173_L	0.583	0.16
244_V	277_T	0.582	0.16
168_A	171_S	0.580	0.16
195_Y	264_P	0.579	0.16
75_V	79_S	0.579	0.16
178_G	208_E	0.579	0.16
51_F	167_G	0.578	0.16
56_A	117_E	0.578	0.16
175_V	215_E	0.575	0.16
215_E	264_P	0.574	0.16
265_V	349_R	0.573	0.16
88_D	93_V	0.572	0.16
195_Y	277_T	0.572	0.16
193_G	197_S	0.571	0.16
298_T	349_R	0.571	0.16
269_L	281_I	0.571	0.16
50_E	83_K	0.570	0.16
6_N	29_E	0.568	0.15
239_N	335_L	0.567	0.15
180_L	339_G	0.567	0.15
21_V	290_L	0.567	0.15
17_F	252_A	0.565	0.15
94_L	167_G	0.565	0.15
49_S	166_S	0.564	0.15
71_N	180_L	0.560	0.15
73_I	180_L	0.559	0.15
272_G	328_Q	0.559	0.15
41_L	226_R	0.557	0.15
307_T	319_G	0.556	0.15
182_V	275_Y	0.554	0.15
48_H	337_A	0.554	0.15
74_K	118_E	0.554	0.15
164_G	278_G	0.551	0.15
217_N	239_N	0.549	0.15
110_E	296_L	0.546	0.15
62_K	349_R	0.546	0.15
157_E	161_A	0.545	0.15
165_L	174_F	0.545	0.15
269_L	350_F	0.542	0.15
158_V	161_A	0.541	0.15
284_L	341_H	0.540	0.15
120_Q	128_D	0.540	0.15
171_S	294_T	0.538	0.15
293_L	305_L	0.538	0.15
185_S	252_A	0.538	0.15
166_S	302_V	0.537	0.15
202_K	263_N	0.537	0.15
42_A	312_S	0.536	0.15
74_K	259_E	0.533	0.15
166_S	195_Y	0.533	0.15
267_S	340_T	0.531	0.14
249_V	254_D	0.530	0.14
35_K	43_E	0.530	0.14
17_F	231_F	0.529	0.14
5_E	50_E	0.528	0.14
9_L	174_F	0.527	0.14
160_A	201_E	0.525	0.14
191_A	269_L	0.524	0.14
161_A	183_G	0.524	0.14
98_E	337_A	0.523	0.14
213_E	240_L	0.523	0.14
239_N	293_L	0.523	0.14
72_K	215_E	0.522	0.14
54_E	62_K	0.519	0.14
196_L	316_I	0.518	0.14
204_V	271_T	0.518	0.14
295_G	320_I	0.517	0.14
185_S	341_H	0.516	0.14
269_L	284_L	0.515	0.14
257_Y	305_L	0.515	0.14
101_D	167_G	0.514	0.14
133_E	309_I	0.513	0.14
53_R	334_L	0.512	0.14
297_I	301_I	0.512	0.14
207_Q	314_I	0.511	0.14
46_K	112_E	0.510	0.14
24_K	39_F	0.510	0.14
142_K	192_I	0.508	0.14
232_T	306_S	0.506	0.14
193_G	336_A	0.506	0.14
122_L	225_L	0.505	0.14
105_Y	251_V	0.504	0.14
234_L	325_K	0.501	0.14
60_G	71_N	0.501	0.14
61_L	305_L	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4etrA	1	0.338	98.6	0.911	Contact Map
2fzfA	2	0.4113	98.5	0.914	Contact Map
1vjxA	1	0.4	98.3	0.918	Contact Map
2oh3A	2	0.4056	97.7	0.93	Contact Map
4am5A	6	0.4254	97.6	0.932	Contact Map
4di0A	2	0.3634	97.4	0.934	Contact Map
3qhbA	1	0.4	96.3	0.943	Contact Map
2vzbA	6	0.4254	95.6	0.946	Contact Map
1j30A	5	0.369	95.5	0.947	Contact Map
1nfvA	7	0.4423	95.5	0.947	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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