GREMLIN Database
Q97VP8 - Uncharacterized protein
UniProt: Q97VP8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 355 (335)
Sequences: 330 (255)
Seq/√Len: 13.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_A177_V5.3001.00
50_E54_E4.5491.00
137_G143_S3.8201.00
35_K39_F3.3180.99
308_F326_G3.2780.98
137_G142_K3.2680.98
16_L53_R3.2150.98
60_G64_K3.0450.97
60_G63_V2.9620.97
166_S296_L2.9080.97
296_L300_Y2.6370.94
191_A299_S2.5570.93
19_H40_K2.4990.92
321_S324_K2.4650.92
281_I339_G2.4630.92
49_S53_R2.4580.92
320_I324_K2.3850.90
191_A339_G2.3310.89
163_S300_Y2.2830.88
215_E223_V2.2440.87
165_L178_G2.2190.87
21_V64_K2.2110.86
280_I284_L2.1660.85
56_A61_L2.1340.84
180_L287_L2.1120.84
146_D194_A1.9780.79
196_L320_I1.9630.79
290_L294_T1.9260.78
210_K243_K1.9150.77
197_S336_A1.8890.76
265_V269_L1.8820.76
191_A263_N1.8720.75
157_E275_Y1.8390.74
45_E48_H1.7800.72
162_V283_I1.7770.71
295_G321_S1.7770.71
166_S286_Y1.7700.71
338_L342_G1.7640.71
23_S46_K1.7550.70
242_K246_L1.7120.69
202_K295_G1.7070.68
19_H79_S1.6760.67
180_L283_I1.6550.66
174_F178_G1.6420.65
246_L291_S1.6370.65
288_I339_G1.6260.64
120_Q123_K1.6170.64
132_H136_L1.5900.63
304_G334_L1.5890.63
300_Y334_L1.5780.62
74_K134_K1.5750.62
341_H345_Y1.5750.62
146_D328_Q1.5690.61
135_V195_Y1.5680.61
61_L64_K1.5670.61
156_V186_G1.5590.61
196_L201_E1.5480.60
243_K247_S1.5370.60
48_H98_E1.5350.60
146_D275_Y1.5290.59
51_F55_I1.5040.58
194_A328_Q1.4990.58
309_I312_S1.4870.57
212_L254_D1.4850.57
149_Y198_T1.4730.56
176_A231_F1.4410.55
14_E72_K1.4410.55
186_G336_A1.4380.55
275_Y307_T1.4370.55
342_G346_L1.4320.54
96_S181_I1.4300.54
102_I180_L1.4200.54
148_V276_I1.4170.53
199_K202_K1.4150.53
290_L298_T1.4130.53
292_G295_G1.4090.53
30_R41_L1.4080.53
191_A277_T1.4060.53
231_F312_S1.4030.53
294_T298_T1.3990.52
186_G307_T1.3980.52
5_E58_K1.3920.52
131_V231_F1.3860.52
194_A267_S1.3810.52
177_V238_L1.3770.51
259_E339_G1.3760.51
291_S346_L1.3640.51
9_L13_E1.3610.50
116_S120_Q1.3510.50
75_V248_L1.3460.50
210_K214_L1.3440.50
191_A281_I1.3350.49
170_S178_G1.3070.48
165_L286_Y1.2950.47
5_E99_E1.2920.47
51_F113_M1.2910.47
294_T297_I1.2890.47
72_K301_I1.2850.46
215_E253_E1.2840.46
59_R312_S1.2820.46
194_A271_T1.2810.46
177_V242_K1.2760.46
166_S175_V1.2740.46
150_G190_M1.2720.46
48_H91_I1.2710.46
146_D272_G1.2640.45
211_R240_L1.2630.45
217_N248_L1.2610.45
162_V175_V1.2580.45
224_Q246_L1.2530.45
46_K65_G1.2480.44
149_Y192_I1.2470.44
17_F20_E1.2430.44
307_T336_A1.2400.44
271_T328_Q1.2390.44
43_E293_L1.2300.43
58_K61_L1.2290.43
191_A216_K1.2280.43
206_I246_L1.2280.43
21_V24_K1.2230.43
194_A272_G1.2220.43
146_D271_T1.2200.43
342_G349_R1.2170.43
226_R333_A1.2090.42
214_L243_K1.2060.42
45_E98_E1.1980.42
327_I331_S1.1910.41
177_V222_S1.1910.41
210_K248_L1.1860.41
197_S307_T1.1800.41
43_E294_T1.1780.41
249_V252_A1.1770.41
156_V197_S1.1760.41
284_L301_I1.1710.40
50_E293_L1.1710.40
31_D286_Y1.1620.40
272_G275_Y1.1610.40
258_P277_T1.1600.40
212_L253_E1.1480.39
304_G330_A1.1470.39
222_S248_L1.1300.38
166_S265_V1.1280.38
186_G197_S1.1170.38
36_K280_I1.1140.37
49_S168_A1.1130.37
262_E271_T1.1120.37
194_A275_Y1.1040.37
14_E181_I1.1030.37
157_E182_V1.1010.37
148_V314_I1.0990.37
90_T199_K1.0970.37
149_Y201_E1.0950.36
265_V291_S1.0910.36
49_S75_V1.0880.36
145_G186_G1.0820.36
308_F313_I1.0740.35
191_A264_P1.0700.35
238_L242_K1.0690.35
179_G283_I1.0660.35
156_V336_A1.0600.35
210_K217_N1.0590.35
286_Y334_L1.0590.35
55_I191_A1.0570.35
116_S123_K1.0550.34
185_S206_I1.0480.34
14_E162_V1.0460.34
46_K191_A1.0460.34
51_F110_E1.0430.34
11_N168_A1.0390.34
165_L168_A1.0370.34
118_E121_R1.0360.34
273_L313_I1.0350.33
145_G198_T1.0330.33
9_L287_L1.0330.33
133_E136_L1.0300.33
95_E132_H1.0270.33
211_R217_N1.0270.33
169_I318_S1.0240.33
59_R242_K1.0130.32
257_Y261_K1.0110.32
296_L305_L1.0060.32
186_G275_Y1.0040.32
212_L249_V1.0020.32
5_E64_K1.0010.32
116_S122_L1.0000.32
117_E343_L0.9980.32
239_N339_G0.9970.32
102_I283_I0.9960.32
286_Y304_G0.9960.32
283_I287_L0.9910.31
46_K264_P0.9870.31
145_G307_T0.9870.31
146_D267_S0.9850.31
149_Y307_T0.9760.31
223_V253_E0.9730.31
158_V194_A0.9710.30
80_L281_I0.9660.30
198_T201_E0.9660.30
85_L89_I0.9660.30
11_N108_L0.9640.30
35_K77_F0.9640.30
263_N274_S0.9530.30
20_E75_V0.9420.29
180_L331_S0.9340.29
197_S275_Y0.9340.29
287_L298_T0.9320.29
59_R162_V0.9310.29
157_E271_T0.9300.29
77_F294_T0.9260.28
145_G149_Y0.9240.28
271_T275_Y0.9200.28
295_G304_G0.9170.28
275_Y336_A0.9150.28
79_S121_R0.9120.28
113_M116_S0.9110.28
91_I229_N0.9100.28
149_Y330_A0.9100.28
311_G326_G0.9040.27
80_L84_I0.8990.27
286_Y349_R0.8990.27
27_E61_L0.8970.27
111_M269_L0.8950.27
104_K283_I0.8930.27
159_L303_A0.8910.27
27_E43_E0.8900.27
119_K126_M0.8880.27
54_E263_N0.8860.27
116_S127_V0.8840.27
292_G296_L0.8820.27
206_I242_K0.8780.26
29_E41_L0.8730.26
5_E61_L0.8730.26
186_G268_A0.8710.26
27_E206_I0.8680.26
91_I98_E0.8670.26
214_L228_V0.8640.26
157_E186_G0.8640.26
148_V274_S0.8630.26
14_E90_T0.8630.26
179_G299_S0.8610.26
50_E53_R0.8600.26
77_F246_L0.8560.25
72_K250_N0.8550.25
97_S297_I0.8510.25
80_L134_K0.8450.25
21_V90_T0.8360.25
78_Y148_V0.8350.25
41_L118_E0.8350.25
156_V275_Y0.8310.24
228_V242_K0.8280.24
5_E59_R0.8270.24
93_V195_Y0.8260.24
158_V328_Q0.8250.24
277_T345_Y0.8170.24
161_A194_A0.8160.24
244_V248_L0.8130.24
12_Y16_L0.8110.24
223_V254_D0.8100.24
158_V183_G0.8090.24
252_A298_T0.8020.23
167_G286_Y0.8010.23
25_L98_E0.8010.23
118_E123_K0.8010.23
64_K331_S0.7990.23
91_I125_I0.7990.23
322_P330_A0.7990.23
156_V194_A0.7970.23
204_V328_Q0.7940.23
162_V299_S0.7930.23
249_V253_E0.7920.23
23_S248_L0.7920.23
191_A267_S0.7880.23
263_N331_S0.7880.23
84_I283_I0.7860.23
166_S199_K0.7810.22
214_L280_I0.7800.22
231_F295_G0.7800.22
108_L222_S0.7750.22
133_E334_L0.7750.22
180_L238_L0.7720.22
158_V279_A0.7720.22
192_I201_E0.7720.22
156_V198_T0.7720.22
198_T307_T0.7700.22
243_K286_Y0.7670.22
37_T42_A0.7640.22
239_N316_I0.7630.22
258_P266_K0.7620.22
191_A260_V0.7620.22
248_L302_V0.7610.22
118_E281_I0.7590.22
144_V303_A0.7580.22
231_F275_Y0.7520.21
274_S277_T0.7500.21
137_G283_I0.7490.21
55_I148_V0.7420.21
145_G197_S0.7370.21
72_K249_V0.7360.21
146_D158_V0.7340.21
167_G177_V0.7330.21
110_E113_M0.7320.21
183_G194_A0.7300.21
75_V168_A0.7300.21
157_E307_T0.7300.21
115_S122_L0.7290.21
167_G334_L0.7280.21
178_G191_A0.7240.20
157_E194_A0.7240.20
74_K254_D0.7200.20
273_L305_L0.7200.20
145_G319_G0.7190.20
126_M130_A0.7170.20
160_A230_F0.7140.20
63_V236_V0.7130.20
44_M175_V0.7060.20
10_K250_N0.7030.20
177_V181_I0.6990.20
200_S205_K0.6960.19
122_L125_I0.6950.19
157_E197_S0.6940.19
288_I341_H0.6930.19
40_K338_L0.6910.19
146_D157_E0.6910.19
54_E111_M0.6870.19
183_G275_Y0.6850.19
275_Y328_Q0.6840.19
33_E58_K0.6830.19
248_L281_I0.6820.19
212_L264_P0.6810.19
180_L276_I0.6770.19
249_V346_L0.6750.19
54_E73_I0.6750.19
204_V272_G0.6710.19
74_K263_N0.6700.19
304_G308_F0.6670.18
105_Y212_L0.6670.18
74_K250_N0.6640.18
184_V315_G0.6630.18
223_V239_N0.6620.18
161_A182_V0.6590.18
78_Y90_T0.6590.18
273_L277_T0.6540.18
186_G271_T0.6530.18
46_K73_I0.6520.18
156_V307_T0.6520.18
17_F49_S0.6520.18
243_K313_I0.6510.18
165_L283_I0.6500.18
121_R210_K0.6500.18
199_K296_L0.6490.18
152_S182_V0.6490.18
211_R244_V0.6470.18
258_P274_S0.6460.18
206_I237_N0.6450.18
161_A271_T0.6440.18
163_S326_G0.6440.18
90_T277_T0.6420.18
148_V301_I0.6410.18
58_K251_V0.6400.18
24_K83_K0.6390.18
162_V339_G0.6380.18
145_G152_S0.6370.18
172_P293_L0.6350.17
75_V217_N0.6320.17
90_T181_I0.6310.17
57_E60_G0.6300.17
186_G193_G0.6300.17
51_F101_D0.6300.17
157_E272_G0.6260.17
200_S318_S0.6250.17
173_L177_V0.6250.17
31_D258_P0.6230.17
187_T307_T0.6230.17
145_G336_A0.6220.17
254_D288_I0.6210.17
318_S322_P0.6200.17
117_E123_K0.6170.17
35_K242_K0.6160.17
165_L316_I0.6150.17
299_S316_I0.6140.17
85_L345_Y0.6140.17
20_E43_E0.6130.17
246_L273_L0.6130.17
13_E16_L0.6130.17
76_D142_K0.6130.17
161_A186_G0.6120.17
166_S320_I0.6120.17
91_I227_L0.6100.17
300_Y309_I0.6100.17
19_H349_R0.6100.17
90_T283_I0.6090.17
250_N301_I0.6090.17
143_S201_E0.6080.17
8_I12_Y0.6080.17
15_E22_Y0.6070.17
182_V271_T0.6070.17
211_R326_G0.6070.17
202_K256_L0.6050.17
241_A245_S0.6040.17
14_E41_L0.6030.16
19_H49_S0.6030.16
20_E53_R0.6020.16
183_G262_E0.6010.16
243_K248_L0.6010.16
267_S272_G0.5980.16
129_E215_E0.5980.16
259_E302_V0.5950.16
64_K88_D0.5920.16
283_I286_Y0.5910.16
158_V276_I0.5900.16
20_E49_S0.5880.16
50_E237_N0.5870.16
217_N246_L0.5860.16
117_E120_Q0.5850.16
78_Y284_L0.5850.16
142_K149_Y0.5850.16
16_L30_R0.5840.16
54_E173_L0.5830.16
244_V277_T0.5820.16
168_A171_S0.5800.16
195_Y264_P0.5790.16
75_V79_S0.5790.16
178_G208_E0.5790.16
51_F167_G0.5780.16
56_A117_E0.5780.16
175_V215_E0.5750.16
215_E264_P0.5740.16
265_V349_R0.5730.16
88_D93_V0.5720.16
195_Y277_T0.5720.16
193_G197_S0.5710.16
298_T349_R0.5710.16
269_L281_I0.5710.16
50_E83_K0.5700.16
6_N29_E0.5680.15
239_N335_L0.5670.15
180_L339_G0.5670.15
21_V290_L0.5670.15
17_F252_A0.5650.15
94_L167_G0.5650.15
49_S166_S0.5640.15
71_N180_L0.5600.15
73_I180_L0.5590.15
272_G328_Q0.5590.15
41_L226_R0.5570.15
307_T319_G0.5560.15
182_V275_Y0.5540.15
48_H337_A0.5540.15
74_K118_E0.5540.15
164_G278_G0.5510.15
217_N239_N0.5490.15
110_E296_L0.5460.15
62_K349_R0.5460.15
157_E161_A0.5450.15
165_L174_F0.5450.15
269_L350_F0.5420.15
158_V161_A0.5410.15
284_L341_H0.5400.15
120_Q128_D0.5400.15
171_S294_T0.5380.15
293_L305_L0.5380.15
185_S252_A0.5380.15
166_S302_V0.5370.15
202_K263_N0.5370.15
42_A312_S0.5360.15
74_K259_E0.5330.15
166_S195_Y0.5330.15
267_S340_T0.5310.14
249_V254_D0.5300.14
35_K43_E0.5300.14
17_F231_F0.5290.14
5_E50_E0.5280.14
9_L174_F0.5270.14
160_A201_E0.5250.14
191_A269_L0.5240.14
161_A183_G0.5240.14
98_E337_A0.5230.14
213_E240_L0.5230.14
239_N293_L0.5230.14
72_K215_E0.5220.14
54_E62_K0.5190.14
196_L316_I0.5180.14
204_V271_T0.5180.14
295_G320_I0.5170.14
185_S341_H0.5160.14
269_L284_L0.5150.14
257_Y305_L0.5150.14
101_D167_G0.5140.14
133_E309_I0.5130.14
53_R334_L0.5120.14
297_I301_I0.5120.14
207_Q314_I0.5110.14
46_K112_E0.5100.14
24_K39_F0.5100.14
142_K192_I0.5080.14
232_T306_S0.5060.14
193_G336_A0.5060.14
122_L225_L0.5050.14
105_Y251_V0.5040.14
234_L325_K0.5010.14
60_G71_N0.5010.14
61_L305_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4etrA 1 0.338 98.6 0.911 Contact Map
2fzfA 2 0.4113 98.5 0.914 Contact Map
1vjxA 1 0.4 98.3 0.918 Contact Map
2oh3A 2 0.4056 97.7 0.93 Contact Map
4am5A 6 0.4254 97.6 0.932 Contact Map
4di0A 2 0.3634 97.4 0.934 Contact Map
3qhbA 1 0.4 96.3 0.943 Contact Map
2vzbA 6 0.4254 95.6 0.946 Contact Map
1j30A 5 0.369 95.5 0.947 Contact Map
1nfvA 7 0.4423 95.5 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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