SFSA - SULSO - GREMLIN Contacts

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SFSA - Sugar fermentation stimulation protein homolog

UniProt:	Q97VP5	Sequences: MNESNSQDLTRVSPFYIKEGFSVYEFTEKLFEAYVIERINRFLVKVTLDGEEILVHLHDPGRLKELIYPGNLVLIRETKGNKTKFSITAAYANSRFIVLDSRLHNIIASKFIPKIYEKEVKVGNSRIDFKYDNTYLEVKGCTLVENEIAYFPDAPTERGRKHLKELRELMRKGFNAILLILVMRNDAKCFLPNEKTDPKFSVEFWDSIKEGLKVYIKTFSLIGNKIVYVGDIPLCKTNLT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	240 (209)
Sequences:	1452 (1078)
Seq/√Len:	74.6

ECOLI - SFSA
SULSO - SFSA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
109_S	118_K	4.002	1.00
156_T	159_G	3.892	1.00
175_N	213_K	3.348	1.00
109_S	113_P	3.072	1.00
194_E	201_S	3.024	1.00
194_E	205_W	2.880	1.00
32_E	72_L	2.652	1.00
112_I	129_F	2.625	1.00
58_H	86_S	2.588	1.00
108_A	179_L	2.554	1.00
160_R	203_E	2.483	1.00
74_L	96_F	2.271	1.00
47_T	52_E	2.271	1.00
72_L	91_Y	2.270	1.00
171_R	210_E	2.182	1.00
46_V	75_I	2.140	1.00
77_E	84_K	1.974	1.00
169_L	174_F	1.906	1.00
135_Y	169_L	1.859	1.00
164_K	206_D	1.843	1.00
204_F	214_V	1.837	1.00
37_E	45_K	1.831	1.00
98_V	183_M	1.794	1.00
120_V	135_Y	1.770	1.00
201_S	205_W	1.762	1.00
34_Y	47_T	1.755	1.00
123_G	165_E	1.745	1.00
48_L	53_I	1.741	1.00
160_R	197_D	1.733	1.00
46_V	73_V	1.729	1.00
55_V	75_I	1.679	1.00
44_V	57_L	1.678	1.00
145_E	195_K	1.660	1.00
122_V	169_L	1.650	1.00
149_A	190_F	1.646	1.00
163_L	178_L	1.601	0.99
117_E	120_V	1.597	0.99
25_E	225_K	1.558	0.99
199_K	202_V	1.507	0.99
31_F	75_I	1.465	0.99
148_I	189_C	1.457	0.99
167_R	170_M	1.442	0.99
193_N	196_T	1.441	0.99
108_A	181_L	1.435	0.99
66_L	90_A	1.405	0.99
74_L	91_Y	1.403	0.99
33_A	46_V	1.400	0.99
167_R	203_E	1.393	0.99
81_N	86_S	1.386	0.98
135_Y	174_F	1.383	0.98
134_T	177_I	1.364	0.98
108_A	112_I	1.356	0.98
73_V	87_I	1.351	0.98
208_I	214_V	1.348	0.98
124_N	165_E	1.337	0.98
207_S	212_L	1.320	0.98
122_V	127_I	1.320	0.98
115_I	132_D	1.319	0.98
150_Y	195_K	1.318	0.98
148_I	191_L	1.317	0.98
118_K	129_F	1.312	0.98
71_N	90_A	1.309	0.98
125_S	165_E	1.306	0.98
217_K	228_Y	1.301	0.98
220_S	229_V	1.300	0.98
167_R	207_S	1.295	0.98
107_I	226_I	1.280	0.97
131_Y	136_L	1.269	0.97
31_F	77_E	1.263	0.97
103_L	106_I	1.238	0.97
168_E	171_R	1.235	0.97
76_R	88_T	1.235	0.97
53_I	75_I	1.232	0.97
104_H	140_G	1.213	0.96
177_I	215_Y	1.207	0.96
216_I	234_L	1.207	0.96
124_N	161_K	1.203	0.96
136_L	179_L	1.182	0.96
190_F	234_L	1.181	0.96
62_R	65_E	1.178	0.96
177_I	213_K	1.163	0.95
149_A	187_A	1.162	0.95
88_T	100_D	1.158	0.95
218_T	230_G	1.155	0.95
68_Y	71_N	1.149	0.95
45_K	54_L	1.137	0.95
190_F	216_I	1.117	0.94
163_L	204_F	1.113	0.94
33_A	75_I	1.109	0.94
182_V	232_I	1.107	0.94
144_V	187_A	1.102	0.94
33_A	73_V	1.099	0.94
91_Y	96_F	1.093	0.94
57_L	87_I	1.086	0.93
167_R	210_E	1.082	0.93
25_E	224_N	1.082	0.93
55_V	83_T	1.069	0.93
219_F	228_Y	1.067	0.93
45_K	52_E	1.046	0.92
39_I	43_L	1.043	0.92
78_T	86_S	1.041	0.92
203_E	207_S	1.039	0.92
192_P	205_W	1.036	0.92
218_T	229_V	1.034	0.92
222_I	225_K	1.031	0.92
31_F	49_D	1.031	0.92
125_S	161_K	1.029	0.91
170_M	176_A	1.023	0.91
160_R	164_K	1.020	0.91
98_V	140_G	1.020	0.91
129_F	136_L	1.017	0.91
133_N	174_F	1.017	0.91
182_V	216_I	1.015	0.91
157_E	160_R	1.009	0.91
142_T	154_A	1.004	0.90
109_S	129_F	1.001	0.90
108_A	129_F	1.001	0.90
167_R	206_D	0.999	0.90
39_I	45_K	0.997	0.90
150_Y	190_F	0.996	0.90
154_A	196_T	0.991	0.90
74_L	89_A	0.986	0.90
103_L	226_I	0.974	0.89
185_N	220_S	0.967	0.89
147_E	188_K	0.965	0.89
192_P	201_S	0.957	0.88
55_V	87_I	0.949	0.88
206_D	210_E	0.947	0.88
44_V	87_I	0.946	0.88
183_M	219_F	0.935	0.87
160_R	199_K	0.933	0.87
77_E	85_F	0.929	0.87
53_I	84_K	0.926	0.86
164_K	203_E	0.923	0.86
112_I	179_L	0.922	0.86
130_K	133_N	0.915	0.86
100_D	104_H	0.914	0.86
136_L	177_I	0.909	0.85
192_P	204_F	0.905	0.85
108_A	138_V	0.903	0.85
168_E	172_K	0.899	0.85
32_E	74_L	0.895	0.85
36_I	47_T	0.894	0.84
35_V	44_V	0.892	0.84
167_R	171_R	0.890	0.84
62_R	154_A	0.885	0.84
36_I	52_E	0.879	0.83
78_T	81_N	0.877	0.83
184_R	187_A	0.876	0.83
144_V	184_R	0.874	0.83
106_I	118_K	0.871	0.83
181_L	228_Y	0.865	0.82
217_K	231_D	0.860	0.82
220_S	227_V	0.856	0.82
131_Y	134_T	0.854	0.82
35_V	67_I	0.853	0.82
76_R	100_D	0.849	0.81
53_I	85_F	0.844	0.81
76_R	86_S	0.844	0.81
215_Y	231_D	0.842	0.81
75_I	85_F	0.842	0.81
88_T	103_L	0.840	0.81
150_Y	191_L	0.838	0.80
199_K	203_E	0.837	0.80
121_K	161_K	0.837	0.80
198_P	202_V	0.828	0.80
59_D	63_L	0.824	0.79
129_F	138_V	0.821	0.79
107_I	181_L	0.818	0.79
66_L	97_I	0.813	0.78
127_I	135_Y	0.804	0.78
160_R	167_R	0.802	0.77
120_V	125_S	0.801	0.77
55_V	85_F	0.800	0.77
44_V	73_V	0.794	0.77
159_G	163_L	0.792	0.77
170_M	175_N	0.781	0.76
61_G	153_D	0.775	0.75
47_T	50_G	0.773	0.75
141_C	180_I	0.772	0.75
67_I	71_N	0.769	0.74
31_F	85_F	0.765	0.74
62_R	155_P	0.762	0.74
28_E	76_R	0.761	0.74
48_L	51_E	0.749	0.72
116_Y	129_F	0.749	0.72
156_T	192_P	0.747	0.72
122_V	165_E	0.747	0.72
86_S	100_D	0.747	0.72
63_L	140_G	0.746	0.72
97_I	187_A	0.744	0.72
40_N	43_L	0.744	0.72
144_V	147_E	0.735	0.71
129_F	179_L	0.729	0.70
178_L	200_F	0.721	0.70
143_L	193_N	0.719	0.69
67_I	90_A	0.713	0.69
178_L	190_F	0.712	0.69
39_I	54_L	0.708	0.68
185_N	221_L	0.707	0.68
192_P	234_L	0.706	0.68
34_Y	72_L	0.705	0.68
32_E	223_G	0.703	0.68
170_M	212_L	0.700	0.67
89_A	96_F	0.699	0.67
178_L	214_V	0.699	0.67
95_R	186_D	0.697	0.67
112_I	136_L	0.693	0.67
87_I	90_A	0.692	0.66
179_L	217_K	0.692	0.66
121_K	124_N	0.691	0.66
117_E	130_K	0.690	0.66
60_P	154_A	0.672	0.64
182_V	190_F	0.668	0.64
48_L	75_I	0.665	0.63
134_T	175_N	0.658	0.63
214_V	234_L	0.653	0.62
149_A	184_R	0.651	0.62
62_R	142_T	0.640	0.60
49_D	52_E	0.640	0.60
35_V	87_I	0.635	0.60
30_L	89_A	0.634	0.60
65_E	196_T	0.632	0.59
157_E	199_K	0.631	0.59
143_L	196_T	0.630	0.59
59_D	153_D	0.629	0.59
25_E	110_K	0.628	0.59
95_R	187_A	0.627	0.59
161_K	164_K	0.625	0.59
58_H	104_H	0.624	0.58
96_F	223_G	0.615	0.57
58_H	105_N	0.611	0.57
164_K	167_R	0.611	0.57
112_I	116_Y	0.608	0.57
175_N	215_Y	0.607	0.56
65_E	68_Y	0.606	0.56
95_R	184_R	0.604	0.56
168_E	210_E	0.602	0.56
108_A	136_L	0.602	0.56
145_E	150_Y	0.598	0.55
110_K	114_K	0.597	0.55
35_V	43_L	0.597	0.55
203_E	206_D	0.593	0.55
42_F	101_S	0.593	0.55
43_L	54_L	0.590	0.54
139_K	158_R	0.589	0.54
137_E	158_R	0.588	0.54
118_K	121_K	0.588	0.54
181_L	219_F	0.585	0.54
155_P	193_N	0.582	0.53
40_N	62_R	0.581	0.53
164_K	199_K	0.581	0.53
48_L	52_E	0.579	0.53
33_A	53_I	0.577	0.53
74_L	223_G	0.570	0.52
189_C	233_P	0.569	0.52
79_K	84_K	0.567	0.51
92_A	184_R	0.566	0.51
57_L	63_L	0.566	0.51
40_N	54_L	0.565	0.51
66_L	204_F	0.564	0.51
33_A	48_L	0.564	0.51
109_S	116_Y	0.559	0.50
98_V	107_I	0.559	0.50
33_A	83_T	0.559	0.50
39_I	63_L	0.557	0.50
89_A	98_V	0.554	0.50
163_L	167_R	0.553	0.50
180_I	204_F	0.551	0.49
134_T	213_K	0.551	0.49
122_V	125_S	0.550	0.49
36_I	48_L	0.548	0.49
34_Y	70_G	0.546	0.49
46_V	55_V	0.546	0.49
104_H	183_M	0.543	0.48
127_I	169_L	0.542	0.48
216_I	232_I	0.542	0.48
91_Y	94_S	0.541	0.48
141_C	232_I	0.539	0.48
31_F	48_L	0.538	0.48
105_N	119_E	0.538	0.48
43_L	83_T	0.535	0.47
98_V	104_H	0.535	0.47
101_S	140_G	0.534	0.47
143_L	161_K	0.533	0.47
228_Y	231_D	0.532	0.47
144_V	186_D	0.531	0.47
124_N	127_I	0.531	0.47
227_V	233_P	0.530	0.47
170_M	173_G	0.529	0.47
205_W	208_I	0.529	0.47
36_I	93_N	0.529	0.47
55_V	73_V	0.528	0.47
135_Y	176_A	0.528	0.47
164_K	168_E	0.526	0.46
40_N	100_D	0.526	0.46
131_Y	177_I	0.525	0.46
58_H	102_R	0.522	0.46
59_D	87_I	0.519	0.45
172_K	209_K	0.518	0.45
116_Y	131_Y	0.517	0.45
121_K	127_I	0.517	0.45
127_I	130_K	0.516	0.45
187_A	190_F	0.515	0.45
218_T	232_I	0.513	0.45
104_H	142_T	0.512	0.45
102_R	107_I	0.512	0.45
122_V	172_K	0.512	0.45
169_L	176_A	0.510	0.44
163_L	207_S	0.508	0.44
111_F	217_K	0.507	0.44
40_N	200_F	0.506	0.44
33_A	55_V	0.503	0.43
179_L	215_Y	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dapA	1	0.8875	100	0.133	Contact Map
4da2A	1	0.9	100	0.136	Contact Map
2o8rA	2	0.8292	54.9	0.955	Contact Map
1jt8A	1	0.4083	49.4	0.956	Contact Map
3wbkC	1	0.0417	39.9	0.959	Contact Map
1xdpA	4	0.8292	37	0.959	Contact Map
4hs5A	1	0.4292	21.4	0.964	Contact Map
4mnoA	1	0.375	20.3	0.964	Contact Map
2qs7A	3	0.3917	17.7	0.965	Contact Map
1v4pA	2	0.375	15.8	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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