GREMLIN Database
SFSA - Sugar fermentation stimulation protein homolog
UniProt: Q97VP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (209)
Sequences: 1452 (1078)
Seq/√Len: 74.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_S118_K4.0021.00
156_T159_G3.8921.00
175_N213_K3.3481.00
109_S113_P3.0721.00
194_E201_S3.0241.00
194_E205_W2.8801.00
32_E72_L2.6521.00
112_I129_F2.6251.00
58_H86_S2.5881.00
108_A179_L2.5541.00
160_R203_E2.4831.00
74_L96_F2.2711.00
47_T52_E2.2711.00
72_L91_Y2.2701.00
171_R210_E2.1821.00
46_V75_I2.1401.00
77_E84_K1.9741.00
169_L174_F1.9061.00
135_Y169_L1.8591.00
164_K206_D1.8431.00
204_F214_V1.8371.00
37_E45_K1.8311.00
98_V183_M1.7941.00
120_V135_Y1.7701.00
201_S205_W1.7621.00
34_Y47_T1.7551.00
123_G165_E1.7451.00
48_L53_I1.7411.00
160_R197_D1.7331.00
46_V73_V1.7291.00
55_V75_I1.6791.00
44_V57_L1.6781.00
145_E195_K1.6601.00
122_V169_L1.6501.00
149_A190_F1.6461.00
163_L178_L1.6010.99
117_E120_V1.5970.99
25_E225_K1.5580.99
199_K202_V1.5070.99
31_F75_I1.4650.99
148_I189_C1.4570.99
167_R170_M1.4420.99
193_N196_T1.4410.99
108_A181_L1.4350.99
66_L90_A1.4050.99
74_L91_Y1.4030.99
33_A46_V1.4000.99
167_R203_E1.3930.99
81_N86_S1.3860.98
135_Y174_F1.3830.98
134_T177_I1.3640.98
108_A112_I1.3560.98
73_V87_I1.3510.98
208_I214_V1.3480.98
124_N165_E1.3370.98
207_S212_L1.3200.98
122_V127_I1.3200.98
115_I132_D1.3190.98
150_Y195_K1.3180.98
148_I191_L1.3170.98
118_K129_F1.3120.98
71_N90_A1.3090.98
125_S165_E1.3060.98
217_K228_Y1.3010.98
220_S229_V1.3000.98
167_R207_S1.2950.98
107_I226_I1.2800.97
131_Y136_L1.2690.97
31_F77_E1.2630.97
103_L106_I1.2380.97
168_E171_R1.2350.97
76_R88_T1.2350.97
53_I75_I1.2320.97
104_H140_G1.2130.96
177_I215_Y1.2070.96
216_I234_L1.2070.96
124_N161_K1.2030.96
136_L179_L1.1820.96
190_F234_L1.1810.96
62_R65_E1.1780.96
177_I213_K1.1630.95
149_A187_A1.1620.95
88_T100_D1.1580.95
218_T230_G1.1550.95
68_Y71_N1.1490.95
45_K54_L1.1370.95
190_F216_I1.1170.94
163_L204_F1.1130.94
33_A75_I1.1090.94
182_V232_I1.1070.94
144_V187_A1.1020.94
33_A73_V1.0990.94
91_Y96_F1.0930.94
57_L87_I1.0860.93
167_R210_E1.0820.93
25_E224_N1.0820.93
55_V83_T1.0690.93
219_F228_Y1.0670.93
45_K52_E1.0460.92
39_I43_L1.0430.92
78_T86_S1.0410.92
203_E207_S1.0390.92
192_P205_W1.0360.92
218_T229_V1.0340.92
222_I225_K1.0310.92
31_F49_D1.0310.92
125_S161_K1.0290.91
170_M176_A1.0230.91
160_R164_K1.0200.91
98_V140_G1.0200.91
129_F136_L1.0170.91
133_N174_F1.0170.91
182_V216_I1.0150.91
157_E160_R1.0090.91
142_T154_A1.0040.90
109_S129_F1.0010.90
108_A129_F1.0010.90
167_R206_D0.9990.90
39_I45_K0.9970.90
150_Y190_F0.9960.90
154_A196_T0.9910.90
74_L89_A0.9860.90
103_L226_I0.9740.89
185_N220_S0.9670.89
147_E188_K0.9650.89
192_P201_S0.9570.88
55_V87_I0.9490.88
206_D210_E0.9470.88
44_V87_I0.9460.88
183_M219_F0.9350.87
160_R199_K0.9330.87
77_E85_F0.9290.87
53_I84_K0.9260.86
164_K203_E0.9230.86
112_I179_L0.9220.86
130_K133_N0.9150.86
100_D104_H0.9140.86
136_L177_I0.9090.85
192_P204_F0.9050.85
108_A138_V0.9030.85
168_E172_K0.8990.85
32_E74_L0.8950.85
36_I47_T0.8940.84
35_V44_V0.8920.84
167_R171_R0.8900.84
62_R154_A0.8850.84
36_I52_E0.8790.83
78_T81_N0.8770.83
184_R187_A0.8760.83
144_V184_R0.8740.83
106_I118_K0.8710.83
181_L228_Y0.8650.82
217_K231_D0.8600.82
220_S227_V0.8560.82
131_Y134_T0.8540.82
35_V67_I0.8530.82
76_R100_D0.8490.81
53_I85_F0.8440.81
76_R86_S0.8440.81
215_Y231_D0.8420.81
75_I85_F0.8420.81
88_T103_L0.8400.81
150_Y191_L0.8380.80
199_K203_E0.8370.80
121_K161_K0.8370.80
198_P202_V0.8280.80
59_D63_L0.8240.79
129_F138_V0.8210.79
107_I181_L0.8180.79
66_L97_I0.8130.78
127_I135_Y0.8040.78
160_R167_R0.8020.77
120_V125_S0.8010.77
55_V85_F0.8000.77
44_V73_V0.7940.77
159_G163_L0.7920.77
170_M175_N0.7810.76
61_G153_D0.7750.75
47_T50_G0.7730.75
141_C180_I0.7720.75
67_I71_N0.7690.74
31_F85_F0.7650.74
62_R155_P0.7620.74
28_E76_R0.7610.74
48_L51_E0.7490.72
116_Y129_F0.7490.72
156_T192_P0.7470.72
122_V165_E0.7470.72
86_S100_D0.7470.72
63_L140_G0.7460.72
97_I187_A0.7440.72
40_N43_L0.7440.72
144_V147_E0.7350.71
129_F179_L0.7290.70
178_L200_F0.7210.70
143_L193_N0.7190.69
67_I90_A0.7130.69
178_L190_F0.7120.69
39_I54_L0.7080.68
185_N221_L0.7070.68
192_P234_L0.7060.68
34_Y72_L0.7050.68
32_E223_G0.7030.68
170_M212_L0.7000.67
89_A96_F0.6990.67
178_L214_V0.6990.67
95_R186_D0.6970.67
112_I136_L0.6930.67
87_I90_A0.6920.66
179_L217_K0.6920.66
121_K124_N0.6910.66
117_E130_K0.6900.66
60_P154_A0.6720.64
182_V190_F0.6680.64
48_L75_I0.6650.63
134_T175_N0.6580.63
214_V234_L0.6530.62
149_A184_R0.6510.62
62_R142_T0.6400.60
49_D52_E0.6400.60
35_V87_I0.6350.60
30_L89_A0.6340.60
65_E196_T0.6320.59
157_E199_K0.6310.59
143_L196_T0.6300.59
59_D153_D0.6290.59
25_E110_K0.6280.59
95_R187_A0.6270.59
161_K164_K0.6250.59
58_H104_H0.6240.58
96_F223_G0.6150.57
58_H105_N0.6110.57
164_K167_R0.6110.57
112_I116_Y0.6080.57
175_N215_Y0.6070.56
65_E68_Y0.6060.56
95_R184_R0.6040.56
168_E210_E0.6020.56
108_A136_L0.6020.56
145_E150_Y0.5980.55
110_K114_K0.5970.55
35_V43_L0.5970.55
203_E206_D0.5930.55
42_F101_S0.5930.55
43_L54_L0.5900.54
139_K158_R0.5890.54
137_E158_R0.5880.54
118_K121_K0.5880.54
181_L219_F0.5850.54
155_P193_N0.5820.53
40_N62_R0.5810.53
164_K199_K0.5810.53
48_L52_E0.5790.53
33_A53_I0.5770.53
74_L223_G0.5700.52
189_C233_P0.5690.52
79_K84_K0.5670.51
92_A184_R0.5660.51
57_L63_L0.5660.51
40_N54_L0.5650.51
66_L204_F0.5640.51
33_A48_L0.5640.51
109_S116_Y0.5590.50
98_V107_I0.5590.50
33_A83_T0.5590.50
39_I63_L0.5570.50
89_A98_V0.5540.50
163_L167_R0.5530.50
180_I204_F0.5510.49
134_T213_K0.5510.49
122_V125_S0.5500.49
36_I48_L0.5480.49
34_Y70_G0.5460.49
46_V55_V0.5460.49
104_H183_M0.5430.48
127_I169_L0.5420.48
216_I232_I0.5420.48
91_Y94_S0.5410.48
141_C232_I0.5390.48
31_F48_L0.5380.48
105_N119_E0.5380.48
43_L83_T0.5350.47
98_V104_H0.5350.47
101_S140_G0.5340.47
143_L161_K0.5330.47
228_Y231_D0.5320.47
144_V186_D0.5310.47
124_N127_I0.5310.47
227_V233_P0.5300.47
170_M173_G0.5290.47
205_W208_I0.5290.47
36_I93_N0.5290.47
55_V73_V0.5280.47
135_Y176_A0.5280.47
164_K168_E0.5260.46
40_N100_D0.5260.46
131_Y177_I0.5250.46
58_H102_R0.5220.46
59_D87_I0.5190.45
172_K209_K0.5180.45
116_Y131_Y0.5170.45
121_K127_I0.5170.45
127_I130_K0.5160.45
187_A190_F0.5150.45
218_T232_I0.5130.45
104_H142_T0.5120.45
102_R107_I0.5120.45
122_V172_K0.5120.45
169_L176_A0.5100.44
163_L207_S0.5080.44
111_F217_K0.5070.44
40_N200_F0.5060.44
33_A55_V0.5030.43
179_L215_Y0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dapA 1 0.8875 100 0.133 Contact Map
4da2A 1 0.9 100 0.136 Contact Map
2o8rA 2 0.8292 54.9 0.955 Contact Map
1jt8A 1 0.4083 49.4 0.956 Contact Map
3wbkC 1 0.0417 39.9 0.959 Contact Map
1xdpA 4 0.8292 37 0.959 Contact Map
4hs5A 1 0.4292 21.4 0.964 Contact Map
4mnoA 1 0.375 20.3 0.964 Contact Map
2qs7A 3 0.3917 17.7 0.965 Contact Map
1v4pA 2 0.375 15.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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