GREMLIN Database
Q97VP1 - Uncharacterized protein
UniProt: Q97VP1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 506 (467)
Sequences: 1080 (824)
Seq/√Len: 38.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_T202_R5.2541.00
23_I61_F4.6771.00
272_K275_D4.5391.00
457_I466_F4.4511.00
260_I345_Y3.9361.00
149_K183_E3.7951.00
86_P90_F3.7021.00
253_A357_Y3.6231.00
49_R303_T3.5611.00
337_M342_N3.5251.00
414_V428_I3.4361.00
51_G54_R3.4041.00
346_N349_R3.3971.00
77_S82_L3.3711.00
164_L219_F3.3511.00
27_T35_I3.3181.00
172_D264_V3.1141.00
37_D310_R3.0921.00
83_F205_S3.0651.00
337_M341_G2.9631.00
76_I81_Y2.9561.00
296_S380_S2.9451.00
14_V23_I2.8021.00
267_R345_Y2.7351.00
336_E340_S2.7131.00
454_E467_T2.7051.00
376_E382_N2.7021.00
258_E261_A2.6941.00
81_Y134_Q2.6721.00
354_I368_G2.6671.00
448_E451_D2.6231.00
385_I388_R2.6111.00
297_L329_V2.5471.00
181_T226_R2.4891.00
454_E465_E2.4591.00
363_R374_I2.4381.00
256_L330_G2.4271.00
90_F125_Y2.4221.00
374_I377_L2.4161.00
44_E64_L2.3331.00
52_K244_E2.3281.00
419_D424_D2.3141.00
347_F369_L2.3051.00
123_D127_E2.2630.99
292_I383_P2.2500.99
350_E365_I2.2340.99
274_D278_N2.2170.99
8_R82_L2.1780.99
188_F215_L2.1290.99
22_I54_R2.1090.99
407_L414_V2.0930.99
8_R77_S2.0790.99
140_K161_V2.0570.99
173_Q179_S1.9900.99
339_D392_F1.9810.99
9_N64_L1.9320.98
375_D379_F1.9290.98
452_K470_P1.9220.98
163_S212_Y1.9150.98
367_E373_N1.8930.98
52_K246_Y1.8820.98
444_N447_L1.8250.98
165_G170_E1.8240.98
333_M337_M1.8170.98
341_G346_N1.8100.97
191_S207_V1.8020.97
112_T131_S1.7870.97
152_T188_F1.7750.97
457_I464_I1.7750.97
342_N346_N1.7710.97
303_T306_I1.7610.97
252_V362_V1.7590.97
131_S202_R1.7330.97
75_A88_S1.7160.96
456_V463_L1.7060.96
29_V87_A1.6940.96
374_I381_R1.6940.96
458_N463_L1.6920.96
22_I56_F1.6880.96
11_Y62_R1.6650.96
84_I133_I1.6630.96
149_K185_I1.6580.96
240_N243_S1.6550.96
377_L380_S1.6530.96
42_V91_P1.6480.96
374_I378_V1.6460.95
24_I94_T1.6200.95
390_S394_K1.6120.95
65_I72_Q1.5860.94
428_I455_L1.5770.94
346_N350_E1.5710.94
20_E56_F1.5700.94
81_Y153_I1.5690.94
362_V366_A1.5680.94
328_I386_F1.5230.93
206_I219_F1.5100.93
432_D459_R1.4990.93
332_I389_L1.4970.93
404_Y422_P1.4780.92
195_F217_R1.4730.92
112_T185_I1.4610.92
428_I457_I1.4570.92
342_N369_L1.4330.91
9_N62_R1.4310.91
437_I455_L1.4290.91
32_S36_R1.4290.91
110_H151_S1.4190.90
458_N461_G1.4190.90
148_H223_Y1.4160.90
113_L131_S1.4060.90
141_L147_N1.4050.90
141_L149_K1.4030.90
155_E462_R1.3900.89
350_E354_I1.3800.89
172_D220_I1.3760.89
342_N370_G1.3740.89
313_N318_V1.3630.89
12_I23_I1.3580.88
92_F97_E1.3560.88
365_I368_G1.3480.88
45_I61_F1.3440.88
260_I267_R1.3390.88
377_L381_R1.3330.87
129_A241_Y1.3310.87
337_M340_S1.3300.87
217_R265_P1.3240.87
63_Y66_Q1.3240.87
13_E60_K1.3230.87
83_F134_Q1.3220.87
14_V93_Q1.3210.87
423_A427_G1.3150.87
394_K397_F1.3130.87
213_K275_D1.3090.86
109_I120_F1.3070.86
217_R220_I1.3060.86
358_T361_N1.3030.86
162_E165_G1.3020.86
287_L324_Q1.3000.86
259_Y263_I1.2990.86
314_N318_V1.2950.86
96_E99_Y1.2910.86
206_I218_L1.2880.85
336_E339_D1.2860.85
68_L76_I1.2790.85
334_D338_I1.2730.85
7_P43_V1.2700.85
113_L122_A1.2580.84
233_R237_L1.2490.84
292_I325_L1.2420.83
422_P471_D1.2410.83
36_R73_R1.2410.83
98_E124_N1.2360.83
175_I264_V1.2320.83
441_S458_N1.2300.83
23_I57_V1.2240.82
296_S377_L1.2180.82
124_N127_E1.2050.81
134_Q153_I1.1960.81
132_P200_H1.1920.81
235_K358_T1.1880.80
410_D453_L1.1860.80
452_K469_I1.1860.80
350_E368_G1.1830.80
76_I80_D1.1740.80
438_N460_E1.1660.79
150_I164_L1.1620.79
130_D199_E1.1600.79
107_W136_S1.1600.79
23_I91_P1.1560.79
130_D200_H1.1550.79
436_G458_N1.1520.78
182_N202_R1.1500.78
442_S447_L1.1440.78
108_P139_L1.1350.77
249_L253_A1.1340.77
246_Y306_I1.1280.77
306_I310_R1.1270.77
448_E469_I1.1230.77
132_P199_E1.1190.76
80_D137_P1.1120.76
439_G454_E1.1060.75
294_R419_D1.1040.75
61_F65_I1.1010.75
443_S447_L1.0910.74
139_L149_K1.0880.74
435_V463_L1.0870.74
103_I128_F1.0850.74
37_D306_I1.0840.74
341_G370_G1.0830.74
68_L72_Q1.0760.73
298_A379_F1.0750.73
110_H139_L1.0710.73
25_F42_V1.0710.73
36_R218_L1.0710.73
434_I437_I1.0650.73
81_Y189_R1.0650.73
256_L378_V1.0630.72
69_S307_K1.0510.72
152_T378_V1.0500.72
112_T127_E1.0500.72
42_V65_I1.0450.71
134_Q189_R1.0440.71
61_F66_Q1.0420.71
452_K467_T1.0370.71
259_Y344_I1.0360.70
217_R262_V1.0290.70
337_M370_G1.0270.70
162_E166_K1.0260.70
46_D62_R1.0260.70
250_L322_Y1.0250.70
347_F362_V1.0150.69
32_S196_G1.0100.69
456_V465_E1.0090.68
331_L335_L1.0040.68
248_E359_Y1.0030.68
66_Q69_S0.9960.67
259_Y334_D0.9930.67
102_K121_C0.9900.67
435_V458_N0.9890.67
120_F133_I0.9870.67
11_Y385_I0.9860.67
106_R137_P0.9770.66
428_I434_I0.9750.66
337_M369_L0.9750.66
364_D368_G0.9740.66
67_A75_A0.9710.65
195_F309_Y0.9700.65
125_Y129_A0.9670.65
156_L161_V0.9630.65
363_R379_F0.9620.65
417_V420_D0.9600.65
280_I331_L0.9540.64
143_E147_N0.9530.64
237_L247_T0.9470.63
144_I179_S0.9420.63
287_L322_Y0.9390.63
252_V256_L0.9380.63
311_R319_G0.9370.63
246_Y305_W0.9300.62
54_R220_I0.9230.61
188_F206_I0.9200.61
306_I319_G0.9190.61
215_L219_F0.9160.61
53_N242_E0.9150.61
300_S319_G0.9140.61
443_S446_N0.9130.61
86_P133_I0.9110.60
412_K434_I0.9080.60
151_S185_I0.9050.60
114_K121_C0.9030.60
36_R305_W0.9020.60
116_V121_C0.9020.60
437_I442_S0.9000.59
76_I153_I0.8940.59
95_I269_K0.8920.59
318_V325_L0.8860.58
32_S72_Q0.8850.58
197_G322_Y0.8850.58
220_I265_P0.8820.58
49_R306_I0.8760.57
198_I322_Y0.8750.57
311_R315_F0.8690.57
8_R259_Y0.8660.56
40_R310_R0.8650.56
68_L81_Y0.8650.56
123_D420_D0.8640.56
337_M346_N0.8610.56
76_I134_Q0.8580.56
354_I365_I0.8560.56
136_S251_W0.8550.56
275_D278_N0.8500.55
28_W230_K0.8500.55
260_I348_F0.8470.55
455_L466_F0.8470.55
232_I366_A0.8450.55
71_D198_I0.8440.55
73_R76_I0.8420.54
464_I467_T0.8420.54
126_N239_I0.8390.54
296_S378_V0.8380.54
192_D461_G0.8370.54
32_S307_K0.8360.54
260_I344_I0.8360.54
27_T37_D0.8330.54
36_R198_I0.8320.53
256_L285_A0.8310.53
405_C437_I0.8290.53
92_F242_E0.8280.53
152_T242_E0.8280.53
360_G364_D0.8260.53
66_Q313_N0.8230.53
36_R206_I0.8220.53
144_I173_Q0.8220.53
114_K127_E0.8200.52
405_C468_I0.8180.52
434_I442_S0.8180.52
231_K352_Y0.8180.52
417_V423_A0.8170.52
284_L328_I0.8160.52
190_R208_I0.8140.52
24_I92_F0.8140.52
169_F181_T0.8130.52
50_I53_N0.8110.52
132_P250_L0.8100.52
21_G96_E0.8100.52
198_I218_L0.8080.51
199_E250_L0.8080.51
27_T39_E0.8070.51
32_S309_Y0.8050.51
143_E454_E0.8010.51
164_L188_F0.8000.51
191_S194_D0.7980.50
30_P132_P0.7970.50
244_E300_S0.7960.50
85_N352_Y0.7950.50
252_V366_A0.7930.50
128_F168_T0.7920.50
114_K183_E0.7900.50
384_P388_R0.7880.50
407_L428_I0.7860.49
66_Q317_N0.7820.49
104_N329_V0.7820.49
292_I318_V0.7800.49
40_R312_D0.7800.49
14_V39_E0.7760.48
236_D248_E0.7760.48
451_D455_L0.7760.48
279_Y341_G0.7740.48
264_V268_T0.7690.48
205_S337_M0.7680.48
238_K245_T0.7680.48
38_T75_A0.7670.48
335_L390_S0.7670.48
29_V75_A0.7650.47
359_Y363_R0.7640.47
116_V119_W0.7620.47
36_R309_Y0.7560.47
397_F401_G0.7560.47
30_P198_I0.7560.47
422_P426_A0.7510.46
428_I466_F0.7490.46
449_C470_P0.7490.46
436_G463_L0.7480.46
192_D436_G0.7470.46
234_P291_G0.7450.46
7_P64_L0.7450.46
20_E59_D0.7430.46
32_S198_I0.7430.46
369_L372_Q0.7420.45
32_S71_D0.7410.45
330_G344_I0.7410.45
61_F364_D0.7400.45
102_K105_V0.7400.45
176_F224_F0.7400.45
127_E201_E0.7380.45
25_F125_Y0.7380.45
88_S125_Y0.7370.45
273_V439_G0.7370.45
34_V311_R0.7340.45
360_G402_F0.7320.45
307_K310_R0.7310.44
262_V276_T0.7310.44
225_H323_Y0.7300.44
221_H323_Y0.7300.44
221_H225_H0.7300.44
126_N241_Y0.7290.44
24_I242_E0.7290.44
340_S372_Q0.7270.44
82_L107_W0.7260.44
37_D244_E0.7240.44
176_F345_Y0.7220.44
448_E470_P0.7220.44
433_E441_S0.7210.44
398_V410_D0.7180.43
38_T88_S0.7170.43
286_W308_Y0.7170.43
378_V381_R0.7170.43
115_K120_F0.7170.43
276_T314_N0.7160.43
29_V198_I0.7150.43
274_D452_K0.7140.43
62_R66_Q0.7130.43
236_D249_L0.7130.43
104_N119_W0.7130.43
421_S431_G0.7120.43
249_L357_Y0.7120.43
18_G95_I0.7120.43
131_S241_Y0.7110.43
335_L393_F0.7080.42
169_F186_F0.7080.42
449_C452_K0.7070.42
65_I68_L0.7060.42
315_F319_G0.7060.42
271_V279_Y0.7060.42
366_A374_I0.7050.42
233_R357_Y0.7050.42
32_S37_D0.7050.42
25_F38_T0.7040.42
124_N384_P0.7040.42
26_P128_F0.7040.42
209_S223_Y0.7030.42
282_N298_A0.7020.42
343_S347_F0.7000.42
308_Y320_I0.7000.42
176_F232_I0.6990.42
339_D393_F0.6970.41
44_E294_R0.6930.41
88_S378_V0.6930.41
171_I264_V0.6930.41
25_F242_E0.6930.41
286_W324_Q0.6910.41
5_I235_K0.6870.41
265_P276_T0.6830.40
290_P418_E0.6820.40
197_G321_S0.6810.40
204_S219_F0.6810.40
102_K118_D0.6810.40
81_Y135_A0.6800.40
10_K89_V0.6790.40
200_H250_L0.6790.40
32_S73_R0.6790.40
32_S258_E0.6780.40
29_V253_A0.6770.40
19_R106_R0.6770.40
304_T322_Y0.6770.40
290_P294_R0.6760.40
60_K63_Y0.6750.40
278_N411_N0.6720.39
187_F191_S0.6710.39
21_G61_F0.6710.39
436_G456_V0.6700.39
11_Y60_K0.6690.39
222_E225_H0.6680.39
222_E323_Y0.6680.39
266_L273_V0.6680.39
440_I462_R0.6670.39
233_R238_K0.6660.39
33_Y200_H0.6650.39
175_I338_I0.6640.39
448_E454_E0.6600.38
237_L241_Y0.6600.38
198_I309_Y0.6590.38
451_D465_E0.6580.38
347_F366_A0.6580.38
200_H322_Y0.6580.38
36_R71_D0.6570.38
206_I261_A0.6570.38
448_E453_L0.6550.38
248_E298_A0.6550.38
29_V85_N0.6520.38
339_D391_K0.6520.38
22_I50_I0.6490.37
112_T183_E0.6480.37
196_G322_Y0.6480.37
105_V133_I0.6460.37
357_Y361_N0.6460.37
22_I57_V0.6460.37
37_D308_Y0.6450.37
336_E389_L0.6440.37
93_Q351_L0.6430.37
248_E366_A0.6420.37
82_L136_S0.6420.37
10_K164_L0.6420.37
66_Q70_K0.6410.37
445_L471_D0.6400.37
331_L389_L0.6390.37
50_I396_S0.6390.37
44_E60_K0.6380.36
406_G423_A0.6380.36
87_A211_N0.6350.36
396_S401_G0.6340.36
304_T307_K0.6340.36
308_Y319_G0.6330.36
361_N366_A0.6330.36
331_L390_S0.6300.36
262_V283_T0.6280.36
367_E370_G0.6260.35
28_W305_W0.6250.35
232_I252_V0.6240.35
387_N397_F0.6240.35
90_F105_V0.6230.35
172_D224_F0.6230.35
400_K409_L0.6220.35
33_Y132_P0.6220.35
32_S218_L0.6220.35
208_I218_L0.6210.35
387_N396_S0.6210.35
93_Q96_E0.6200.35
142_I152_T0.6170.35
237_L245_T0.6170.35
450_K454_E0.6170.35
179_S226_R0.6160.35
34_V315_F0.6160.35
36_R322_Y0.6160.35
189_R207_V0.6150.35
116_V275_D0.6150.35
196_G251_W0.6140.35
160_I215_L0.6140.35
94_T97_E0.6140.35
177_S363_R0.6120.34
258_E262_V0.6110.34
363_R367_E0.6100.34
136_S153_I0.6100.34
391_K420_D0.6100.34
60_K66_Q0.6100.34
316_L416_F0.6090.34
228_N291_G0.6090.34
160_I220_I0.6080.34
180_S226_R0.6080.34
425_K471_D0.6060.34
33_Y199_E0.6060.34
48_I62_R0.6050.34
117_G368_G0.6040.34
448_E467_T0.6030.34
261_A330_G0.6030.34
126_N238_K0.6010.33
437_I466_F0.5990.33
278_N281_A0.5990.33
304_T309_Y0.5990.33
275_D299_E0.5990.33
390_S393_F0.5970.33
30_P129_A0.5970.33
120_F340_S0.5970.33
82_L135_A0.5960.33
8_R95_I0.5950.33
124_N416_F0.5940.33
76_I189_R0.5940.33
68_L306_I0.5930.33
29_V32_S0.5930.33
11_Y104_N0.5930.33
64_L370_G0.5930.33
232_I348_F0.5920.33
118_D165_G0.5920.33
73_R148_H0.5920.33
67_A72_Q0.5910.33
286_W289_F0.5900.33
267_R344_I0.5880.32
82_L423_A0.5880.32
71_D308_Y0.5870.32
50_I54_R0.5860.32
246_Y301_S0.5850.32
110_H153_I0.5850.32
121_C387_N0.5850.32
170_E435_V0.5840.32
90_F128_F0.5840.32
452_K471_D0.5840.32
102_K116_V0.5810.32
73_R218_L0.5810.32
11_Y468_I0.5800.32
103_I159_P0.5800.32
262_V271_V0.5780.32
48_I376_E0.5770.32
194_D352_Y0.5770.32
130_D203_S0.5760.31
66_Q72_Q0.5760.31
259_Y393_F0.5750.31
70_K189_R0.5750.31
240_N358_T0.5750.31
33_Y301_S0.5750.31
134_Q210_W0.5750.31
178_D374_I0.5730.31
130_D201_E0.5730.31
37_D300_S0.5710.31
455_L462_R0.5710.31
266_L276_T0.5700.31
431_G434_I0.5700.31
153_I189_R0.5700.31
111_T183_E0.5690.31
236_D390_S0.5680.31
33_Y321_S0.5680.31
346_N431_G0.5670.31
404_Y455_L0.5670.31
285_A378_V0.5660.31
38_T85_N0.5630.31
30_P33_Y0.5630.31
32_S322_Y0.5630.31
246_Y302_Y0.5620.30
338_I345_Y0.5610.30
362_V389_L0.5590.30
100_C105_V0.5590.30
421_S427_G0.5590.30
63_Y72_Q0.5590.30
238_K356_E0.5590.30
73_R309_Y0.5580.30
73_R304_T0.5570.30
159_P163_S0.5570.30
305_W308_Y0.5570.30
73_R305_W0.5570.30
103_I133_I0.5570.30
34_V69_S0.5560.30
198_I325_L0.5530.30
325_L384_P0.5530.30
295_M300_S0.5530.30
46_D277_L0.5520.30
112_T374_I0.5510.30
162_E364_D0.5500.30
73_R317_N0.5500.30
196_G250_L0.5500.30
258_E305_W0.5490.29
294_R319_G0.5480.29
450_K470_P0.5460.29
103_I282_N0.5460.29
241_Y319_G0.5450.29
420_D444_N0.5450.29
442_S445_L0.5450.29
14_V457_I0.5440.29
175_I349_R0.5440.29
169_F295_M0.5440.29
40_R172_D0.5440.29
289_F315_F0.5430.29
112_T182_N0.5430.29
209_S428_I0.5430.29
6_N234_P0.5420.29
218_L309_Y0.5410.29
431_G462_R0.5400.29
83_F189_R0.5390.29
233_R239_I0.5380.29
30_P200_H0.5370.29
20_E58_K0.5370.29
226_R297_L0.5350.28
43_V178_D0.5350.28
192_D278_N0.5340.28
132_P322_Y0.5330.28
141_L443_S0.5330.28
64_L104_N0.5330.28
34_V148_H0.5320.28
259_Y283_T0.5320.28
228_N252_V0.5310.28
49_R52_K0.5310.28
197_G222_E0.5310.28
191_S235_K0.5310.28
277_L281_A0.5300.28
181_T202_R0.5290.28
426_A468_I0.5280.28
402_F409_L0.5280.28
156_L160_I0.5270.28
199_E204_S0.5270.28
76_I136_S0.5270.28
123_D243_S0.5270.28
154_D210_W0.5260.28
259_Y337_M0.5250.28
33_Y130_D0.5250.28
263_I267_R0.5230.28
239_I356_E0.5230.28
283_T324_Q0.5230.28
364_D367_E0.5220.27
299_E404_Y0.5220.27
268_T273_V0.5220.27
119_W348_F0.5220.27
31_G250_L0.5210.27
277_L395_L0.5210.27
148_H291_G0.5210.27
453_L467_T0.5190.27
150_I188_F0.5190.27
451_D470_P0.5190.27
152_T409_L0.5190.27
249_L351_L0.5180.27
335_L389_L0.5170.27
27_T53_N0.5170.27
19_R121_C0.5170.27
284_L348_F0.5160.27
417_V427_G0.5150.27
37_D53_N0.5150.27
329_V435_V0.5150.27
311_R316_L0.5150.27
118_D274_D0.5150.27
26_P125_Y0.5140.27
402_F408_M0.5140.27
266_L393_F0.5140.27
45_I57_V0.5130.27
49_R215_L0.5130.27
274_D469_I0.5120.27
201_E352_Y0.5120.27
263_I338_I0.5120.27
182_N277_L0.5120.27
152_T190_R0.5110.27
197_G227_Y0.5110.27
182_N192_D0.5110.27
438_N454_E0.5110.27
40_R307_K0.5100.27
101_V377_L0.5090.27
420_D434_I0.5090.27
447_L465_E0.5090.27
192_D438_N0.5070.26
11_Y46_D0.5070.26
146_R181_T0.5070.26
148_H305_W0.5060.26
36_R196_G0.5060.26
161_V188_F0.5050.26
278_N347_F0.5040.26
243_S405_C0.5040.26
130_D291_G0.5030.26
29_V72_Q0.5020.26
122_A296_S0.5010.26
104_N387_N0.5010.26
370_G423_A0.5010.26
450_K457_I0.5010.26
139_L151_S0.5000.26
364_D447_L0.5000.26
90_F103_I0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fgmA 4 0.9743 100 0.458 Contact Map
4x2uA 1 0.919 99.8 0.875 Contact Map
4gaaA 2 0.8043 99.8 0.876 Contact Map
1z5hA 3 0.8794 99.8 0.877 Contact Map
4qhpA 1 0.832 99.7 0.879 Contact Map
3b34A 1 0.83 99.7 0.883 Contact Map
3ciaA 1 0.7846 99.7 0.883 Contact Map
4fkeA 1 0.8518 99.7 0.886 Contact Map
3u9wA 1 0.7846 99.7 0.886 Contact Map
4pj6A 2 0.7589 99.7 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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