GREMLIN Database
Q97VP0 - Partial transposase ISC1058
UniProt: Q97VP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (160)
Sequences: 286 (175)
Seq/√Len: 13.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_F95_Y3.0570.98
75_T100_V2.9340.97
50_I154_F2.7830.96
153_L156_A2.7750.96
155_S159_R2.7490.95
28_T31_Q2.6050.94
123_R138_W2.5120.92
145_G148_W2.2730.88
26_T44_K2.2470.87
111_P115_A2.2190.87
64_V165_V2.2080.86
20_D23_G2.0460.82
74_K77_K2.0220.81
93_K112_K2.0130.80
49_E71_S1.9720.79
144_Y151_E1.9520.78
140_E159_R1.8870.76
35_A40_T1.8810.76
16_E29_G1.8430.74
42_D46_L1.7830.72
29_G33_I1.7630.71
57_F156_A1.7470.70
157_V165_V1.7070.68
111_P126_A1.6800.67
46_L156_A1.6510.65
53_D94_A1.6280.64
61_N105_V1.6230.64
24_I156_A1.6150.64
24_I165_V1.6040.63
25_S31_Q1.5970.63
142_K145_G1.5910.62
44_K67_N1.5900.62
27_N44_K1.5690.61
36_K102_K1.5340.59
33_I149_R1.4980.58
57_F153_L1.4950.57
167_Q170_L1.4720.56
111_P130_F1.4570.55
100_V118_K1.4510.55
51_V55_N1.4510.55
24_I64_V1.4460.55
96_D138_W1.4460.55
17_V60_V1.4120.53
114_N124_R1.3910.52
21_A71_S1.3840.51
96_D123_R1.3620.50
18_I90_Y1.3560.50
101_Y110_P1.3370.49
30_G112_K1.3130.48
58_N86_V1.3060.47
25_S96_D1.3010.47
16_E54_N1.2960.47
89_F107_V1.2900.46
134_G138_W1.2870.46
113_K116_S1.2640.45
12_S127_V1.2220.43
117_T127_V1.2210.43
28_T59_V1.2050.42
80_Q85_K1.2040.42
152_S155_S1.1990.42
118_K145_G1.1970.41
107_V126_A1.1940.41
156_A165_V1.1910.41
123_R134_G1.1540.39
22_T48_I1.1530.39
144_Y147_R1.1500.39
52_M149_R1.1490.39
129_E133_L1.1330.38
27_N41_M1.1270.38
88_K170_L1.1190.37
43_S93_K1.1080.37
21_A32_Y1.0800.36
25_S154_F1.0780.35
42_D150_V1.0640.35
70_E73_V1.0610.35
25_S28_T1.0540.34
108_V120_H1.0480.34
35_A41_M1.0470.34
77_K113_K1.0470.34
50_I76_V1.0410.34
64_V129_E1.0160.32
45_F71_S1.0130.32
105_V149_R1.0110.32
34_V40_T1.0090.32
125_K128_S1.0080.32
133_L137_R1.0040.32
49_E78_D1.0030.32
19_V66_S1.0020.32
70_E148_W0.9960.31
19_V44_K0.9940.31
33_I90_Y0.9920.31
95_Y110_P0.9890.31
17_V51_V0.9750.31
18_I54_N0.9740.30
74_K89_F0.9740.30
93_K96_D0.9710.30
74_K113_K0.9670.30
153_L167_Q0.9630.30
61_N78_D0.9440.29
48_I111_P0.9420.29
161_F166_R0.9300.28
19_V122_A0.9300.28
45_F49_E0.9290.28
26_T38_G0.9220.28
139_R145_G0.9210.28
72_A134_G0.9190.28
40_T113_K0.9070.27
83_G121_P0.9010.27
10_E109_V0.8970.27
71_S78_D0.8930.27
39_K164_S0.8860.27
58_N70_E0.8850.27
26_T42_D0.8720.26
18_I26_T0.8690.26
89_F100_V0.8630.26
19_V79_L0.8540.25
58_N63_E0.8420.25
91_G95_Y0.8370.25
97_V100_V0.8370.25
57_F130_F0.8300.24
47_K71_S0.8280.24
72_A106_E0.8230.24
53_D112_K0.8220.24
21_A78_D0.8170.24
28_T37_W0.8120.24
16_E26_T0.8090.23
137_R141_E0.8030.23
61_N121_P0.7990.23
92_D147_R0.7900.23
149_R153_L0.7900.23
66_S69_V0.7890.23
49_E65_T0.7870.23
37_W148_W0.7860.23
43_S168_V0.7860.23
68_E130_F0.7780.22
28_T42_D0.7770.22
65_T71_S0.7750.22
16_E28_T0.7710.22
17_V31_Q0.7660.22
52_M150_V0.7660.22
10_E14_E0.7650.22
70_E81_D0.7620.22
76_V89_F0.7570.22
42_D156_A0.7530.21
82_K85_K0.7470.21
139_R157_V0.7350.21
113_K163_E0.7210.20
18_I155_S0.7170.20
93_K115_A0.7140.20
157_V161_F0.7070.20
67_N98_N0.7060.20
136_D142_K0.7060.20
86_V117_T0.7040.20
115_A127_V0.6970.19
15_L38_G0.6950.19
37_W45_F0.6930.19
47_K65_T0.6880.19
120_H159_R0.6880.19
153_L161_F0.6870.19
35_A139_R0.6730.19
115_A124_R0.6700.19
77_K128_S0.6680.18
47_K92_D0.6640.18
147_R151_E0.6600.18
90_Y108_V0.6570.18
61_N164_S0.6560.18
50_I70_E0.6510.18
56_E120_H0.6510.18
128_S131_R0.6480.18
30_G86_V0.6460.18
113_K121_P0.6440.18
147_R158_K0.6410.18
29_G146_V0.6360.17
25_S42_D0.6310.17
136_D139_R0.6310.17
53_D108_V0.6300.17
28_T46_L0.6300.17
54_N149_R0.6290.17
28_T96_D0.6270.17
77_K82_K0.6220.17
162_G165_V0.6190.17
106_E120_H0.6150.17
33_I139_R0.6080.17
61_N79_L0.6060.17
41_M133_L0.6040.16
61_N94_A0.6030.16
30_G53_D0.6010.16
50_I88_K0.6010.16
56_E107_V0.6010.16
15_L143_G0.6010.16
20_D110_P0.5980.16
72_A122_A0.5980.16
36_K72_A0.5970.16
28_T32_Y0.5940.16
48_I91_G0.5920.16
81_D162_G0.5920.16
83_G140_E0.5920.16
57_F62_A0.5900.16
101_Y111_P0.5880.16
19_V75_T0.5880.16
59_V133_L0.5840.16
132_K169_L0.5840.16
79_L132_K0.5820.16
33_I40_T0.5790.16
112_K118_K0.5770.16
74_K112_K0.5710.16
60_V132_K0.5700.15
63_E70_E0.5680.15
99_E128_S0.5640.15
80_Q121_P0.5570.15
62_A157_V0.5570.15
64_V157_V0.5550.15
69_V99_E0.5510.15
85_K103_T0.5510.15
68_E113_K0.5470.15
79_L105_V0.5470.15
111_P123_R0.5450.15
12_S140_E0.5450.15
53_D96_D0.5440.15
70_E87_K0.5400.15
94_A107_V0.5320.14
75_T101_Y0.5310.14
67_N128_S0.5280.14
12_S170_L0.5280.14
12_S15_L0.5270.14
102_K105_V0.5260.14
11_T14_E0.5230.14
27_N156_A0.5220.14
97_V169_L0.5200.14
79_L143_G0.5190.14
21_A44_K0.5160.14
78_D95_Y0.5160.14
159_R169_L0.5100.14
86_V112_K0.5090.14
94_A124_R0.5060.14
46_L168_V0.5040.14
16_E154_F0.5040.14
22_T94_A0.5020.14
110_P148_W0.5000.14
18_I108_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9826 93.7 0.913 Contact Map
4fw1A 2 0.6919 43.2 0.946 Contact Map
1bcoA 1 0.8081 24.9 0.953 Contact Map
4fw2A 2 0.6686 13.8 0.958 Contact Map
1cxqA 2 0.6919 13 0.958 Contact Map
3f9kA 5 0.6919 9.8 0.961 Contact Map
1k6yA 4 0.6047 7.8 0.962 Contact Map
1c6vA 4 0.593 7.7 0.962 Contact Map
4fcyA 4 0.8663 7.4 0.963 Contact Map
3l3uA 2 0.7558 7 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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