Q97VN7 - SULSO - GREMLIN Contacts

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Q97VN7 - Uncharacterized protein

UniProt:	Q97VN7	Sequences: MDSIDKGILKILLKDARTPQRKIAIMLGISPPAVSYRMEKLFGDIIKRFTVYVNPNFLGRYHGYVAFNNLYDWDGDYIAKIECLEEINVYEIDSKSRVELDEKIRKMSEKLGEPRMIYIPNQMPYSPSKFDLKVVSILKEKPLIKPIELAEELGVSSKTIRRHLRYLYSKKFIRLIPIIDLNKAEISIFAVFTSKVEDGKNFFAKYAFTEIEDDKAGIFVNVVDSMDEARDLALKFKREYDKDAEIMITTKYEFL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	255 (238)
Sequences:	412 (357)
Seq/√Len:	23.1

SULSO - Q97VN7 Q97X78

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_T	196_V	3.259	1.00
122_Q	125_Y	3.170	1.00
189_F	192_F	2.973	1.00
203_F	206_Y	2.854	0.99
196_V	206_Y	2.757	0.99
197_E	201_N	2.746	0.99
199_G	206_Y	2.603	0.99
113_E	122_Q	2.507	0.98
193_T	206_Y	2.501	0.98
199_G	203_F	2.474	0.98
194_S	202_F	2.469	0.98
113_E	121_N	2.467	0.98
121_N	125_Y	2.410	0.98
193_T	204_A	2.361	0.98
195_K	198_D	2.315	0.97
134_V	149_L	2.309	0.97
109_E	113_E	2.307	0.97
107_M	111_L	2.130	0.96
110_K	121_N	2.120	0.95
11_I	18_T	2.091	0.95
153_L	160_I	2.081	0.95
113_E	120_P	2.025	0.94
194_S	203_F	2.018	0.94
193_T	199_G	2.000	0.94
196_V	199_G	1.981	0.93
168_Y	175_L	1.940	0.93
111_L	118_Y	1.921	0.92
111_L	116_M	1.914	0.92
112_G	120_P	1.899	0.92
114_P	118_Y	1.864	0.91
144_I	152_E	1.838	0.90
4_I	29_I	1.837	0.90
193_T	200_K	1.824	0.90
112_G	121_N	1.821	0.90
113_E	119_I	1.786	0.89
193_T	203_F	1.772	0.89
194_S	206_Y	1.771	0.89
113_E	125_Y	1.757	0.88
196_V	204_A	1.734	0.88
196_V	203_F	1.650	0.85
113_E	124_P	1.620	0.84
112_G	122_Q	1.602	0.83
211_I	215_K	1.602	0.83
29_I	33_A	1.581	0.82
114_P	117_I	1.565	0.81
111_L	124_P	1.563	0.81
134_V	153_L	1.525	0.80
109_E	114_P	1.519	0.79
116_M	120_P	1.516	0.79
83_C	89_V	1.515	0.79
113_E	116_M	1.515	0.79
137_I	152_E	1.513	0.79
110_K	113_E	1.507	0.79
200_K	204_A	1.498	0.79
225_S	228_E	1.455	0.76
131_D	163_H	1.453	0.76
15_D	22_K	1.452	0.76
196_V	200_K	1.450	0.76
111_L	122_Q	1.433	0.75
18_T	23_I	1.422	0.75
194_S	204_A	1.415	0.74
8_I	158_K	1.413	0.74
196_V	202_F	1.404	0.74
119_I	122_Q	1.392	0.73
116_M	119_I	1.384	0.73
224_D	228_E	1.361	0.71
106_K	113_E	1.359	0.71
115_R	119_I	1.344	0.70
111_L	125_Y	1.337	0.70
194_S	199_G	1.319	0.69
111_L	121_N	1.316	0.69
100_L	107_M	1.309	0.68
114_P	120_P	1.300	0.68
160_I	173_I	1.292	0.67
112_G	125_Y	1.285	0.67
114_P	119_I	1.283	0.67
116_M	121_N	1.276	0.66
119_I	125_Y	1.273	0.66
51_V	142_P	1.262	0.65
119_I	123_M	1.258	0.65
8_I	23_I	1.254	0.65
164_L	224_D	1.253	0.65
116_M	125_Y	1.253	0.65
115_R	121_N	1.252	0.65
202_F	206_Y	1.248	0.65
66_A	71_Y	1.243	0.64
19_P	56_N	1.234	0.64
58_L	96_S	1.226	0.63
133_K	218_I	1.220	0.63
58_L	127_P	1.218	0.63
186_I	224_D	1.218	0.63
19_P	24_A	1.209	0.62
66_A	88_N	1.208	0.62
113_E	118_Y	1.201	0.61
193_T	202_F	1.200	0.61
100_L	103_K	1.187	0.61
113_E	117_I	1.185	0.60
60_R	102_E	1.177	0.60
235_K	238_R	1.168	0.59
121_N	124_P	1.165	0.59
175_L	212_E	1.161	0.59
20_Q	38_M	1.158	0.59
108_S	112_G	1.155	0.58
2_D	5_D	1.152	0.58
118_Y	121_N	1.148	0.58
114_P	123_M	1.148	0.58
107_M	116_M	1.141	0.57
228_E	231_D	1.132	0.57
134_V	160_I	1.123	0.56
5_D	37_R	1.101	0.55
199_G	202_F	1.099	0.55
8_I	144_I	1.098	0.54
117_I	121_N	1.093	0.54
111_L	115_R	1.092	0.54
171_K	233_A	1.076	0.53
128_S	155_V	1.066	0.52
104_I	113_E	1.066	0.52
223_V	236_F	1.062	0.52
112_G	115_R	1.053	0.51
8_I	21_R	1.053	0.51
15_D	55_P	1.048	0.51
77_Y	80_K	1.019	0.49
4_I	27_L	1.017	0.49
38_M	178_I	1.016	0.49
108_S	125_Y	1.015	0.49
106_K	109_E	1.009	0.48
51_V	173_I	1.004	0.48
134_V	211_I	1.000	0.48
108_S	113_E	0.991	0.47
103_K	109_E	0.985	0.47
200_K	206_Y	0.976	0.46
9_L	130_F	0.975	0.46
107_M	113_E	0.975	0.46
200_K	230_R	0.973	0.46
200_K	208_F	0.972	0.46
31_P	161_R	0.969	0.46
10_K	19_P	0.968	0.45
167_L	213_D	0.966	0.45
108_S	119_I	0.965	0.45
155_V	160_I	0.962	0.45
83_C	166_Y	0.957	0.45
142_P	213_D	0.951	0.44
21_R	183_K	0.950	0.44
27_L	34_V	0.950	0.44
109_E	115_R	0.949	0.44
149_L	213_D	0.947	0.44
110_K	115_R	0.943	0.44
118_Y	122_Q	0.943	0.44
2_D	37_R	0.926	0.43
8_I	159_T	0.923	0.42
56_N	62_H	0.914	0.42
95_K	132_L	0.914	0.42
12_L	17_R	0.912	0.42
199_G	204_A	0.898	0.41
24_A	218_I	0.894	0.40
39_E	50_T	0.886	0.40
15_D	168_Y	0.884	0.40
108_S	123_M	0.883	0.40
20_Q	88_N	0.882	0.40
110_K	122_Q	0.882	0.40
73_W	197_E	0.881	0.40
9_L	102_E	0.875	0.39
8_I	130_F	0.874	0.39
199_G	241_D	0.871	0.39
116_M	124_P	0.871	0.39
30_S	82_E	0.869	0.39
158_K	161_R	0.863	0.38
63_G	77_Y	0.862	0.38
113_E	123_M	0.854	0.38
79_A	176_I	0.852	0.38
115_R	122_Q	0.844	0.37
158_K	194_S	0.841	0.37
111_L	117_I	0.835	0.37
111_L	119_I	0.835	0.37
140_E	190_A	0.828	0.36
4_I	98_V	0.828	0.36
114_P	121_N	0.826	0.36
160_I	191_V	0.823	0.36
5_D	17_R	0.820	0.36
200_K	203_F	0.819	0.35
45_I	83_C	0.819	0.35
118_Y	124_P	0.815	0.35
107_M	122_Q	0.806	0.35
77_Y	168_Y	0.800	0.34
112_G	124_P	0.799	0.34
79_A	214_D	0.799	0.34
13_L	61_Y	0.796	0.34
99_E	103_K	0.795	0.34
238_R	241_D	0.794	0.34
46_I	62_H	0.789	0.34
80_K	212_E	0.788	0.34
21_R	24_A	0.787	0.33
234_L	238_R	0.786	0.33
135_V	147_I	0.786	0.33
137_I	140_E	0.786	0.33
8_I	41_L	0.785	0.33
155_V	223_V	0.784	0.33
135_V	151_E	0.776	0.33
201_N	235_K	0.773	0.33
173_I	217_G	0.771	0.32
82_E	192_F	0.770	0.32
64_Y	177_P	0.766	0.32
129_K	227_D	0.762	0.32
8_I	57_F	0.762	0.32
210_E	230_R	0.759	0.32
16_A	77_Y	0.758	0.32
67_F	90_Y	0.742	0.31
31_P	159_T	0.739	0.31
184_A	192_F	0.738	0.30
39_E	145_K	0.734	0.30
104_I	111_L	0.731	0.30
110_K	120_P	0.730	0.30
24_A	74_D	0.728	0.30
115_R	120_P	0.726	0.30
218_I	221_N	0.725	0.30
70_L	83_C	0.713	0.29
111_L	120_P	0.712	0.29
112_G	118_Y	0.710	0.29
15_D	24_A	0.707	0.29
106_K	110_K	0.706	0.29
129_K	132_L	0.701	0.28
3_S	7_G	0.698	0.28
132_L	234_L	0.696	0.28
36_Y	193_T	0.694	0.28
32_P	176_I	0.693	0.28
100_L	104_I	0.693	0.28
83_C	203_F	0.688	0.28
100_L	109_E	0.688	0.28
11_I	26_M	0.687	0.28
117_I	123_M	0.679	0.27
157_S	186_I	0.678	0.27
112_G	117_I	0.676	0.27
184_A	241_D	0.675	0.27
16_A	158_K	0.673	0.27
19_P	78_I	0.664	0.26
3_S	6_K	0.662	0.26
23_I	156_S	0.661	0.26
164_L	173_I	0.659	0.26
69_N	208_F	0.654	0.26
33_A	36_Y	0.652	0.26
8_I	11_I	0.649	0.26
39_E	168_Y	0.648	0.25
147_I	228_E	0.646	0.25
4_I	34_V	0.643	0.25
134_V	137_I	0.638	0.25
181_L	184_A	0.631	0.25
21_R	181_L	0.630	0.25
94_S	226_M	0.628	0.24
180_D	183_K	0.627	0.24
150_A	223_V	0.626	0.24
15_D	218_I	0.622	0.24
105_R	110_K	0.618	0.24
206_Y	232_L	0.618	0.24
60_R	166_Y	0.616	0.24
136_S	145_K	0.615	0.24
17_R	143_L	0.614	0.24
8_I	18_T	0.611	0.24
104_I	108_S	0.611	0.24
56_N	227_D	0.610	0.23
64_Y	218_I	0.609	0.23
155_V	164_L	0.607	0.23
159_T	162_R	0.604	0.23
51_V	59_G	0.604	0.23
67_F	221_N	0.595	0.23
170_K	179_I	0.593	0.23
47_K	208_F	0.593	0.23
26_M	49_F	0.591	0.23
115_R	118_Y	0.591	0.23
213_D	216_A	0.589	0.22
34_V	228_E	0.584	0.22
95_K	170_K	0.584	0.22
117_I	120_P	0.584	0.22
96_S	102_E	0.583	0.22
116_M	122_Q	0.583	0.22
60_R	92_I	0.582	0.22
117_I	124_P	0.582	0.22
38_M	90_Y	0.582	0.22
85_E	156_S	0.581	0.22
146_P	151_E	0.580	0.22
165_R	188_I	0.580	0.22
54_N	94_S	0.580	0.22
4_I	7_G	0.579	0.22
10_K	42_F	0.578	0.22
75_G	164_L	0.578	0.22
150_A	217_G	0.576	0.22
38_M	79_A	0.576	0.22
107_M	110_K	0.576	0.22
85_E	159_T	0.575	0.22
5_D	76_D	0.574	0.22
178_I	219_F	0.573	0.22
65_V	215_K	0.572	0.22
110_K	116_M	0.571	0.22
105_R	109_E	0.570	0.22
6_K	157_S	0.569	0.21
108_S	120_P	0.568	0.21
9_L	224_D	0.568	0.21
89_V	191_V	0.568	0.21
128_S	225_S	0.568	0.21
99_E	111_L	0.566	0.21
130_F	195_K	0.566	0.21
130_F	140_E	0.566	0.21
164_L	172_F	0.564	0.21
24_A	76_D	0.560	0.21
32_P	222_V	0.560	0.21
126_S	170_K	0.559	0.21
4_I	93_D	0.558	0.21
21_R	90_Y	0.558	0.21
75_G	82_E	0.557	0.21
8_I	31_P	0.555	0.21
20_Q	176_I	0.554	0.21
16_A	142_P	0.553	0.21
88_N	192_F	0.549	0.21
144_I	234_L	0.549	0.21
194_S	201_N	0.548	0.21
51_V	135_V	0.548	0.21
53_V	157_S	0.547	0.20
194_S	239_E	0.547	0.20
200_K	210_E	0.546	0.20
108_S	121_N	0.543	0.20
30_S	85_E	0.543	0.20
115_R	125_Y	0.541	0.20
195_K	241_D	0.540	0.20
32_P	174_R	0.539	0.20
21_R	31_P	0.537	0.20
55_P	92_I	0.535	0.20
108_S	114_P	0.535	0.20
54_N	72_D	0.532	0.20
24_A	161_R	0.530	0.20
151_E	154_G	0.529	0.20
16_A	70_L	0.529	0.20
105_R	113_E	0.528	0.20
96_S	101_D	0.527	0.20
70_L	128_S	0.526	0.20
16_A	161_R	0.525	0.19
22_K	169_S	0.525	0.19
10_K	232_L	0.524	0.19
21_R	27_L	0.523	0.19
133_K	231_D	0.522	0.19
14_K	27_L	0.521	0.19
186_I	194_S	0.520	0.19
157_S	226_M	0.520	0.19
16_A	58_L	0.518	0.19
40_K	44_D	0.517	0.19
27_L	222_V	0.517	0.19
72_D	92_I	0.516	0.19
143_L	163_H	0.515	0.19
104_I	123_M	0.514	0.19
94_S	207_A	0.513	0.19
102_E	108_S	0.513	0.19
66_A	86_E	0.512	0.19
146_P	215_K	0.511	0.19
175_L	178_I	0.507	0.19
63_G	232_L	0.507	0.19
58_L	172_F	0.506	0.19
8_I	77_Y	0.501	0.18
116_M	127_P	0.501	0.18
55_P	60_R	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ch7A	1	0.9608	100	0.427	Contact Map
4un1B	1	0.5255	99.7	0.73	Contact Map
4un1A	1	0.5059	99.7	0.732	Contact Map
2e1cA	1	0.5216	99.7	0.735	Contact Map
4pcqA	2	0.5176	99.7	0.738	Contact Map
2p5vA	5	0.5255	99.7	0.741	Contact Map
2cg4A	6	0.5137	99.7	0.741	Contact Map
3i4pA	5	0.502	99.7	0.743	Contact Map
2ia0A	2	0.5294	99.7	0.745	Contact Map
2pn6A	5	0.502	99.6	0.753	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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