GREMLIN Database
Q97VN7 - Uncharacterized protein
UniProt: Q97VN7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (238)
Sequences: 412 (357)
Seq/√Len: 23.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_T196_V3.2591.00
122_Q125_Y3.1701.00
189_F192_F2.9731.00
203_F206_Y2.8540.99
196_V206_Y2.7570.99
197_E201_N2.7460.99
199_G206_Y2.6030.99
113_E122_Q2.5070.98
193_T206_Y2.5010.98
199_G203_F2.4740.98
194_S202_F2.4690.98
113_E121_N2.4670.98
121_N125_Y2.4100.98
193_T204_A2.3610.98
195_K198_D2.3150.97
134_V149_L2.3090.97
109_E113_E2.3070.97
107_M111_L2.1300.96
110_K121_N2.1200.95
11_I18_T2.0910.95
153_L160_I2.0810.95
113_E120_P2.0250.94
194_S203_F2.0180.94
193_T199_G2.0000.94
196_V199_G1.9810.93
168_Y175_L1.9400.93
111_L118_Y1.9210.92
111_L116_M1.9140.92
112_G120_P1.8990.92
114_P118_Y1.8640.91
144_I152_E1.8380.90
4_I29_I1.8370.90
193_T200_K1.8240.90
112_G121_N1.8210.90
113_E119_I1.7860.89
193_T203_F1.7720.89
194_S206_Y1.7710.89
113_E125_Y1.7570.88
196_V204_A1.7340.88
196_V203_F1.6500.85
113_E124_P1.6200.84
112_G122_Q1.6020.83
211_I215_K1.6020.83
29_I33_A1.5810.82
114_P117_I1.5650.81
111_L124_P1.5630.81
134_V153_L1.5250.80
109_E114_P1.5190.79
116_M120_P1.5160.79
83_C89_V1.5150.79
113_E116_M1.5150.79
137_I152_E1.5130.79
110_K113_E1.5070.79
200_K204_A1.4980.79
225_S228_E1.4550.76
131_D163_H1.4530.76
15_D22_K1.4520.76
196_V200_K1.4500.76
111_L122_Q1.4330.75
18_T23_I1.4220.75
194_S204_A1.4150.74
8_I158_K1.4130.74
196_V202_F1.4040.74
119_I122_Q1.3920.73
116_M119_I1.3840.73
224_D228_E1.3610.71
106_K113_E1.3590.71
115_R119_I1.3440.70
111_L125_Y1.3370.70
194_S199_G1.3190.69
111_L121_N1.3160.69
100_L107_M1.3090.68
114_P120_P1.3000.68
160_I173_I1.2920.67
112_G125_Y1.2850.67
114_P119_I1.2830.67
116_M121_N1.2760.66
119_I125_Y1.2730.66
51_V142_P1.2620.65
119_I123_M1.2580.65
8_I23_I1.2540.65
164_L224_D1.2530.65
116_M125_Y1.2530.65
115_R121_N1.2520.65
202_F206_Y1.2480.65
66_A71_Y1.2430.64
19_P56_N1.2340.64
58_L96_S1.2260.63
133_K218_I1.2200.63
58_L127_P1.2180.63
186_I224_D1.2180.63
19_P24_A1.2090.62
66_A88_N1.2080.62
113_E118_Y1.2010.61
193_T202_F1.2000.61
100_L103_K1.1870.61
113_E117_I1.1850.60
60_R102_E1.1770.60
235_K238_R1.1680.59
121_N124_P1.1650.59
175_L212_E1.1610.59
20_Q38_M1.1580.59
108_S112_G1.1550.58
2_D5_D1.1520.58
118_Y121_N1.1480.58
114_P123_M1.1480.58
107_M116_M1.1410.57
228_E231_D1.1320.57
134_V160_I1.1230.56
5_D37_R1.1010.55
199_G202_F1.0990.55
8_I144_I1.0980.54
117_I121_N1.0930.54
111_L115_R1.0920.54
171_K233_A1.0760.53
128_S155_V1.0660.52
104_I113_E1.0660.52
223_V236_F1.0620.52
112_G115_R1.0530.51
8_I21_R1.0530.51
15_D55_P1.0480.51
77_Y80_K1.0190.49
4_I27_L1.0170.49
38_M178_I1.0160.49
108_S125_Y1.0150.49
106_K109_E1.0090.48
51_V173_I1.0040.48
134_V211_I1.0000.48
108_S113_E0.9910.47
103_K109_E0.9850.47
200_K206_Y0.9760.46
9_L130_F0.9750.46
107_M113_E0.9750.46
200_K230_R0.9730.46
200_K208_F0.9720.46
31_P161_R0.9690.46
10_K19_P0.9680.45
167_L213_D0.9660.45
108_S119_I0.9650.45
155_V160_I0.9620.45
83_C166_Y0.9570.45
142_P213_D0.9510.44
21_R183_K0.9500.44
27_L34_V0.9500.44
109_E115_R0.9490.44
149_L213_D0.9470.44
110_K115_R0.9430.44
118_Y122_Q0.9430.44
2_D37_R0.9260.43
8_I159_T0.9230.42
56_N62_H0.9140.42
95_K132_L0.9140.42
12_L17_R0.9120.42
199_G204_A0.8980.41
24_A218_I0.8940.40
39_E50_T0.8860.40
15_D168_Y0.8840.40
108_S123_M0.8830.40
20_Q88_N0.8820.40
110_K122_Q0.8820.40
73_W197_E0.8810.40
9_L102_E0.8750.39
8_I130_F0.8740.39
199_G241_D0.8710.39
116_M124_P0.8710.39
30_S82_E0.8690.39
158_K161_R0.8630.38
63_G77_Y0.8620.38
113_E123_M0.8540.38
79_A176_I0.8520.38
115_R122_Q0.8440.37
158_K194_S0.8410.37
111_L117_I0.8350.37
111_L119_I0.8350.37
140_E190_A0.8280.36
4_I98_V0.8280.36
114_P121_N0.8260.36
160_I191_V0.8230.36
5_D17_R0.8200.36
200_K203_F0.8190.35
45_I83_C0.8190.35
118_Y124_P0.8150.35
107_M122_Q0.8060.35
77_Y168_Y0.8000.34
112_G124_P0.7990.34
79_A214_D0.7990.34
13_L61_Y0.7960.34
99_E103_K0.7950.34
238_R241_D0.7940.34
46_I62_H0.7890.34
80_K212_E0.7880.34
21_R24_A0.7870.33
234_L238_R0.7860.33
135_V147_I0.7860.33
137_I140_E0.7860.33
8_I41_L0.7850.33
155_V223_V0.7840.33
135_V151_E0.7760.33
201_N235_K0.7730.33
173_I217_G0.7710.32
82_E192_F0.7700.32
64_Y177_P0.7660.32
129_K227_D0.7620.32
8_I57_F0.7620.32
210_E230_R0.7590.32
16_A77_Y0.7580.32
67_F90_Y0.7420.31
31_P159_T0.7390.31
184_A192_F0.7380.30
39_E145_K0.7340.30
104_I111_L0.7310.30
110_K120_P0.7300.30
24_A74_D0.7280.30
115_R120_P0.7260.30
218_I221_N0.7250.30
70_L83_C0.7130.29
111_L120_P0.7120.29
112_G118_Y0.7100.29
15_D24_A0.7070.29
106_K110_K0.7060.29
129_K132_L0.7010.28
3_S7_G0.6980.28
132_L234_L0.6960.28
36_Y193_T0.6940.28
32_P176_I0.6930.28
100_L104_I0.6930.28
83_C203_F0.6880.28
100_L109_E0.6880.28
11_I26_M0.6870.28
117_I123_M0.6790.27
157_S186_I0.6780.27
112_G117_I0.6760.27
184_A241_D0.6750.27
16_A158_K0.6730.27
19_P78_I0.6640.26
3_S6_K0.6620.26
23_I156_S0.6610.26
164_L173_I0.6590.26
69_N208_F0.6540.26
33_A36_Y0.6520.26
8_I11_I0.6490.26
39_E168_Y0.6480.25
147_I228_E0.6460.25
4_I34_V0.6430.25
134_V137_I0.6380.25
181_L184_A0.6310.25
21_R181_L0.6300.25
94_S226_M0.6280.24
180_D183_K0.6270.24
150_A223_V0.6260.24
15_D218_I0.6220.24
105_R110_K0.6180.24
206_Y232_L0.6180.24
60_R166_Y0.6160.24
136_S145_K0.6150.24
17_R143_L0.6140.24
8_I18_T0.6110.24
104_I108_S0.6110.24
56_N227_D0.6100.23
64_Y218_I0.6090.23
155_V164_L0.6070.23
159_T162_R0.6040.23
51_V59_G0.6040.23
67_F221_N0.5950.23
170_K179_I0.5930.23
47_K208_F0.5930.23
26_M49_F0.5910.23
115_R118_Y0.5910.23
213_D216_A0.5890.22
34_V228_E0.5840.22
95_K170_K0.5840.22
117_I120_P0.5840.22
96_S102_E0.5830.22
116_M122_Q0.5830.22
60_R92_I0.5820.22
117_I124_P0.5820.22
38_M90_Y0.5820.22
85_E156_S0.5810.22
146_P151_E0.5800.22
165_R188_I0.5800.22
54_N94_S0.5800.22
4_I7_G0.5790.22
10_K42_F0.5780.22
75_G164_L0.5780.22
150_A217_G0.5760.22
38_M79_A0.5760.22
107_M110_K0.5760.22
85_E159_T0.5750.22
5_D76_D0.5740.22
178_I219_F0.5730.22
65_V215_K0.5720.22
110_K116_M0.5710.22
105_R109_E0.5700.22
6_K157_S0.5690.21
108_S120_P0.5680.21
9_L224_D0.5680.21
89_V191_V0.5680.21
128_S225_S0.5680.21
99_E111_L0.5660.21
130_F195_K0.5660.21
130_F140_E0.5660.21
164_L172_F0.5640.21
24_A76_D0.5600.21
32_P222_V0.5600.21
126_S170_K0.5590.21
4_I93_D0.5580.21
21_R90_Y0.5580.21
75_G82_E0.5570.21
8_I31_P0.5550.21
20_Q176_I0.5540.21
16_A142_P0.5530.21
88_N192_F0.5490.21
144_I234_L0.5490.21
194_S201_N0.5480.21
51_V135_V0.5480.21
53_V157_S0.5470.20
194_S239_E0.5470.20
200_K210_E0.5460.20
108_S121_N0.5430.20
30_S85_E0.5430.20
115_R125_Y0.5410.20
195_K241_D0.5400.20
32_P174_R0.5390.20
21_R31_P0.5370.20
55_P92_I0.5350.20
108_S114_P0.5350.20
54_N72_D0.5320.20
24_A161_R0.5300.20
151_E154_G0.5290.20
16_A70_L0.5290.20
105_R113_E0.5280.20
96_S101_D0.5270.20
70_L128_S0.5260.20
16_A161_R0.5250.19
22_K169_S0.5250.19
10_K232_L0.5240.19
21_R27_L0.5230.19
133_K231_D0.5220.19
14_K27_L0.5210.19
186_I194_S0.5200.19
157_S226_M0.5200.19
16_A58_L0.5180.19
40_K44_D0.5170.19
27_L222_V0.5170.19
72_D92_I0.5160.19
143_L163_H0.5150.19
104_I123_M0.5140.19
94_S207_A0.5130.19
102_E108_S0.5130.19
66_A86_E0.5120.19
146_P215_K0.5110.19
175_L178_I0.5070.19
63_G232_L0.5070.19
58_L172_F0.5060.19
8_I77_Y0.5010.18
116_M127_P0.5010.18
55_P60_R0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ch7A 1 0.9608 100 0.427 Contact Map
4un1B 1 0.5255 99.7 0.73 Contact Map
4un1A 1 0.5059 99.7 0.732 Contact Map
2e1cA 1 0.5216 99.7 0.735 Contact Map
4pcqA 2 0.5176 99.7 0.738 Contact Map
2p5vA 5 0.5255 99.7 0.741 Contact Map
2cg4A 6 0.5137 99.7 0.741 Contact Map
3i4pA 5 0.502 99.7 0.743 Contact Map
2ia0A 2 0.5294 99.7 0.745 Contact Map
2pn6A 5 0.502 99.6 0.753 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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