GREMLIN Database
MDH - Probable malate dehydrogenase
UniProt: Q97VN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (293)
Sequences: 4907 (2855)
Seq/√Len: 166.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_A71_A4.2701.00
73_I232_V3.0371.00
281_R285_N2.9551.00
204_N208_S2.9101.00
96_A128_V2.6511.00
75_L232_V2.6481.00
80_K94_D2.4941.00
118_V228_I2.4911.00
5_A68_V2.4671.00
103_A129_F2.3891.00
68_V110_N2.3591.00
205_Y212_E2.3151.00
23_D233_R2.3121.00
196_G200_E2.2841.00
289_E293_R2.2361.00
240_G265_G2.2341.00
105_Q108_P2.1821.00
258_I284_L2.1621.00
265_G269_G2.0921.00
253_G284_L2.0681.00
240_G269_G2.0681.00
134_K248_P2.0001.00
201_E205_Y1.9741.00
156_K198_T1.9721.00
130_M257_H1.9681.00
107_P132_F1.9681.00
169_A179_L1.9531.00
101_D105_Q1.9481.00
262_I268_I1.9331.00
157_L185_V1.9281.00
258_I288_V1.8821.00
166_G183_V1.8531.00
253_G285_N1.8511.00
100_I104_K1.8441.00
285_N289_E1.8191.00
114_L235_V1.8181.00
263_V270_P1.8161.00
92_F294_V1.7921.00
142_D259_S1.7851.00
282_Q286_K1.7771.00
132_F136_F1.7451.00
99_Q129_F1.7141.00
4_I26_A1.7121.00
3_K28_E1.6691.00
3_K30_I1.6641.00
104_K108_P1.6641.00
140_T228_I1.6491.00
39_P43_E1.6441.00
177_V280_D1.5991.00
278_E281_R1.5781.00
4_I20_V1.5481.00
97_K100_I1.5471.00
168_V178_V1.5441.00
127_S295_Y1.5311.00
86_M94_D1.5311.00
9_V31_L1.5311.00
126_A257_H1.5241.00
65_L109_K1.5151.00
82_R210_P1.5051.00
6_F17_A1.5031.00
278_E282_Q1.5021.00
283_R286_K1.4931.00
233_R237_F1.4871.00
16_I228_I1.4821.00
247_T262_I1.4771.00
127_S131_R1.4771.00
47_R155_K1.4741.00
115_Y129_F1.4691.00
37_E40_E1.4441.00
143_A227_I1.4391.00
66_D69_T1.4221.00
65_L108_P1.4151.00
253_G288_V1.4131.00
200_E204_N1.4121.00
47_R151_S1.4041.00
154_A164_V1.3921.00
153_I164_V1.3891.00
76_I117_M1.3681.00
68_V71_A1.3431.00
41_K216_V1.3321.00
178_V203_E1.3311.00
279_S283_R1.3201.00
117_M129_F1.3191.00
286_K289_E1.3121.00
292_Y296_K1.2841.00
72_D111_P1.2811.00
175_D290_D1.2721.00
49_A226_T1.2711.00
106_L115_Y1.2641.00
18_Y225_A1.2601.00
160_P163_K1.2601.00
73_I116_I1.2561.00
99_Q103_A1.2551.00
181_S280_D1.2421.00
293_R297_E1.2351.00
156_K201_E1.2291.00
74_I106_L1.2261.00
37_E215_R1.2161.00
208_S211_G1.2161.00
238_N266_A1.2121.00
248_P254_E1.2081.00
212_E216_V1.2071.00
87_S90_D1.2041.00
106_L132_F1.2011.00
36_P64_S1.1911.00
163_K186_N1.1891.00
3_K70_N1.1891.00
122_V139_S1.1881.00
263_V269_G1.1871.00
212_E215_R1.1821.00
16_I232_V1.1811.00
16_I75_L1.1801.00
61_G67_D1.1801.00
138_I235_V1.1771.00
20_V29_A1.1681.00
282_Q285_N1.1671.00
230_D241_R1.1631.00
37_E216_V1.1631.00
181_S277_P1.1631.00
114_L136_F1.1561.00
285_N288_V1.1531.00
204_N207_K1.1531.00
20_V25_L1.1521.00
242_V246_A1.1501.00
143_A243_M1.1481.00
18_Y22_F1.1431.00
110_N113_A1.1401.00
80_K83_K1.1351.00
195_K198_T1.1201.00
94_D97_K1.1191.00
250_T272_L1.1191.00
165_T184_K1.1131.00
130_M137_T1.1111.00
135_Q267_E1.1101.00
188_K192_E1.1081.00
120_N172_H1.1041.00
48_H209_I1.1031.00
88_R120_N1.0991.00
74_I113_A1.0961.00
192_E275_V1.0871.00
101_D104_K1.0871.00
112_G133_S1.0841.00
198_T201_E1.0831.00
82_R214_I1.0811.00
242_V263_V1.0811.00
35_V38_L1.0771.00
16_I225_A1.0751.00
88_R172_H1.0741.00
93_I97_K1.0731.00
30_I67_D1.0670.99
91_L95_N1.0570.99
103_A115_Y1.0550.99
76_I129_F1.0480.99
286_K290_D1.0480.99
99_Q125_M1.0470.99
122_V126_A1.0410.99
263_V272_L1.0210.99
72_D112_G1.0170.99
25_L237_F1.0150.99
293_R296_K1.0120.99
11_K221_T1.0110.99
116_I231_I1.0110.99
62_T67_D1.0110.99
175_D287_S1.0080.99
14_Q42_F1.0010.99
162_N239_E0.9950.99
284_L288_V0.9930.99
154_A161_A0.9920.99
64_S67_D0.9910.99
247_T268_I0.9630.99
151_S155_K0.9590.99
30_I71_A0.9590.99
279_S282_Q0.9590.99
80_K98_I0.9570.99
126_A139_S0.9530.99
73_I236_V0.9490.99
32_Y65_L0.9490.99
38_L42_F0.9490.99
90_D93_I0.9460.99
23_D229_K0.9440.99
14_Q225_A0.9440.99
276_L284_L0.9400.99
208_S215_R0.9400.99
86_M90_D0.9370.99
84_P215_R0.9350.99
244_S247_T0.9320.99
17_A31_L0.9320.99
249_R252_Q0.9290.99
179_L276_L0.9280.99
75_L116_I0.9250.99
70_N111_P0.9240.99
184_K187_G0.9200.98
289_E296_K0.9190.98
192_E195_K0.9170.98
175_D286_K0.9150.98
130_M134_K0.9080.98
69_T109_K0.9070.98
189_P192_E0.9020.98
210_P214_I0.8990.98
150_R165_T0.8970.98
133_S136_F0.8950.98
39_P63_N0.8880.98
103_A107_P0.8840.98
149_L166_G0.8830.98
74_I110_N0.8820.98
233_R239_E0.8780.98
71_A74_I0.8750.98
146_T150_R0.8750.98
76_I99_Q0.8730.98
25_L229_K0.8730.98
253_G281_R0.8730.98
124_M294_V0.8690.98
188_K193_V0.8650.98
127_S130_M0.8590.98
116_I232_V0.8520.98
132_F137_T0.8480.97
248_P272_L0.8440.97
82_R211_G0.8420.97
228_I232_V0.8410.97
113_A132_F0.8400.97
66_D109_K0.8390.97
137_T257_H0.8390.97
225_A229_K0.8360.97
260_V271_S0.8350.97
152_Y205_Y0.8320.97
139_S246_A0.8270.97
63_N67_D0.8260.97
9_V42_F0.8250.97
36_P40_E0.8180.97
250_T260_V0.8180.97
60_I63_N0.8170.97
6_F16_I0.8170.97
169_A177_V0.8160.97
203_E207_K0.8160.97
197_L201_E0.8140.97
11_K14_Q0.8140.97
242_V247_T0.8120.97
152_Y155_K0.8120.97
99_Q117_M0.8020.96
289_E292_Y0.8010.96
231_I245_I0.7990.96
65_L102_L0.7980.96
116_I235_V0.7970.96
98_I119_A0.7960.96
30_I63_N0.7920.96
40_E216_V0.7900.96
294_V297_E0.7860.96
245_I262_I0.7850.96
16_I20_V0.7850.96
213_I223_G0.7830.96
143_A231_I0.7800.96
19_S225_A0.7790.96
180_W206_V0.7730.96
260_V270_P0.7690.95
89_R124_M0.7690.95
290_D294_V0.7650.95
71_A110_N0.7640.95
153_I157_L0.7620.95
250_T270_P0.7620.95
82_R91_L0.7560.95
159_V164_V0.7550.95
7_I102_L0.7530.95
191_E199_K0.7530.95
174_E211_G0.7480.95
87_S174_E0.7470.95
76_I102_L0.7470.95
149_L178_V0.7470.95
70_N112_G0.7460.95
159_V185_V0.7450.95
93_I297_E0.7440.95
16_I77_M0.7420.94
82_R86_M0.7420.94
75_L228_I0.7410.94
211_G215_R0.7400.94
78_A98_I0.7400.94
91_L214_I0.7400.94
19_S22_F0.7380.94
40_E63_N0.7360.94
240_G263_V0.7330.94
107_P113_A0.7320.94
36_P63_N0.7290.94
157_L164_V0.7270.94
32_Y68_V0.7260.94
129_F137_T0.7230.94
11_K219_G0.7170.93
28_E56_S0.7170.93
15_T222_W0.7110.93
15_T19_S0.7100.93
107_P115_Y0.7060.93
134_K257_H0.7040.93
42_F225_A0.7000.93
17_A46_L0.6990.93
168_V203_E0.6970.92
114_L138_I0.6970.92
217_M220_T0.6950.92
210_P220_T0.6940.92
127_S255_I0.6920.92
182_T274_G0.6910.92
150_R230_D0.6890.92
250_T273_E0.6890.92
118_V140_T0.6880.92
201_E204_N0.6870.92
149_L183_V0.6870.92
15_T221_T0.6860.92
20_V229_K0.6850.92
97_K101_D0.6820.92
88_R145_E0.6820.92
20_V232_V0.6770.91
135_Q269_G0.6740.91
177_V287_S0.6720.91
214_I219_G0.6700.91
223_G226_T0.6660.91
42_F217_M0.6660.91
76_I103_A0.6640.91
35_V39_P0.6640.91
5_A30_I0.6610.90
83_K94_D0.6580.90
153_I166_G0.6550.90
194_A198_T0.6490.90
169_A274_G0.6470.89
89_R294_V0.6460.89
253_G292_Y0.6460.89
276_L285_N0.6460.89
240_G244_S0.6450.89
249_R273_E0.6430.89
20_V26_A0.6410.89
65_L69_T0.6410.89
21_I46_L0.6410.89
200_E279_S0.6400.89
53_R226_T0.6400.89
242_V245_I0.6380.89
77_M118_V0.6370.89
112_G136_F0.6370.89
89_R290_D0.6330.88
43_E47_R0.6280.88
68_V107_P0.6270.88
122_V140_T0.6260.88
238_N241_R0.6250.88
32_Y102_L0.6240.88
19_S229_K0.6240.88
5_A110_N0.6240.88
234_S239_E0.6220.87
106_L109_K0.6220.87
79_G119_A0.6190.87
145_E148_R0.6160.87
256_I292_Y0.6160.87
288_V292_Y0.6130.87
136_F267_E0.6110.87
65_L105_Q0.6110.87
142_D175_D0.6110.87
172_H210_P0.6090.86
234_S244_S0.6090.86
250_T271_S0.6090.86
100_I128_V0.6060.86
210_P219_G0.6050.86
196_G279_S0.6020.86
179_L182_T0.6010.86
26_A29_A0.6000.86
89_R297_E0.5990.85
4_I29_A0.5970.85
28_E59_V0.5970.85
208_S212_E0.5960.85
18_Y222_W0.5960.85
48_H151_S0.5950.85
14_Q222_W0.5950.85
149_L177_V0.5950.85
154_A159_V0.5950.85
265_G268_I0.5940.85
105_Q109_K0.5940.85
167_Y244_S0.5940.85
248_P252_Q0.5930.85
275_V281_R0.5810.84
6_F29_A0.5790.83
177_V283_R0.5770.83
276_L280_D0.5770.83
256_I288_V0.5770.83
251_Y255_I0.5730.83
247_T257_H0.5710.83
121_P148_R0.5700.83
41_K91_L0.5700.83
12_I118_V0.5700.83
203_E283_R0.5690.82
95_N125_M0.5690.82
21_I29_A0.5680.82
155_K205_Y0.5670.82
100_I131_R0.5660.82
231_I243_M0.5640.82
292_Y295_Y0.5620.82
160_P241_R0.5600.81
86_M91_L0.5600.81
88_R91_L0.5570.81
177_V203_E0.5540.81
191_E195_K0.5540.81
197_L200_E0.5530.81
15_T18_Y0.5530.81
260_V273_E0.5520.81
70_N110_N0.5510.80
241_R244_S0.5510.80
243_M246_A0.5510.80
232_V236_V0.5500.80
42_F222_W0.5470.80
96_A100_I0.5460.80
103_A106_L0.5430.79
13_G17_A0.5430.79
239_E242_V0.5400.79
36_P62_T0.5390.79
277_P281_R0.5370.79
102_L106_L0.5340.78
3_K69_T0.5340.78
84_P218_G0.5330.78
234_S243_M0.5310.78
258_I291_F0.5300.78
179_L277_P0.5300.78
140_T143_A0.5280.78
177_V276_L0.5260.77
243_M247_T0.5260.77
143_A234_S0.5250.77
169_A276_L0.5250.77
120_N220_T0.5240.77
57_T160_P0.5220.77
253_G258_I0.5220.77
213_I217_M0.5220.77
60_I64_S0.5220.77
138_I231_I0.5220.77
6_F20_V0.5220.77
152_Y156_K0.5210.77
230_D239_E0.5170.76
79_G82_R0.5150.76
25_L233_R0.5140.76
140_T259_S0.5110.75
150_R166_G0.5100.75
138_I268_I0.5100.75
171_E220_T0.5090.75
104_K107_P0.5090.75
153_I180_W0.5080.75
238_N265_G0.5050.74
79_G85_G0.5020.74
10_G145_E0.5010.74
17_A29_A0.5000.74
9_V29_A0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nepX 4 0.9675 100 0.255 Contact Map
2d4aB 4 0.9708 100 0.258 Contact Map
4cl3A 4 0.9708 100 0.262 Contact Map
1guzA 4 0.9643 100 0.267 Contact Map
1a5zA 3 0.974 100 0.27 Contact Map
1lldA 3 0.9708 100 0.271 Contact Map
4plzA 4 0.9448 100 0.272 Contact Map
4bgvA 4 0.9903 100 0.278 Contact Map
2v6bA 4 0.8896 100 0.282 Contact Map
4aj2A 4 0.9708 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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