GREMLIN Database
Q97VN3 - Uncharacterized protein
UniProt: Q97VN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 435 (419)
Sequences: 2692 (1854)
Seq/√Len: 90.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_A170_T5.4931.00
166_D169_S4.3351.00
284_I376_T3.9571.00
285_K352_T3.8661.00
63_L111_S3.8651.00
9_E167_E3.7091.00
116_E119_D3.4451.00
28_K421_E3.1381.00
388_R399_E3.0191.00
287_E354_I2.9901.00
273_G320_L2.8821.00
372_T381_T2.8651.00
284_I374_Y2.7561.00
36_A404_Y2.7231.00
287_E372_T2.6991.00
289_E356_D2.6351.00
29_R397_D2.5971.00
346_N350_K2.5871.00
285_K374_Y2.5511.00
282_D376_T2.5351.00
326_K333_A2.5251.00
123_A162_M2.5161.00
289_E370_K2.4731.00
274_K323_T2.4631.00
25_H397_D2.4421.00
287_E352_T2.4381.00
173_A214_A2.3841.00
207_A211_A2.3541.00
131_G154_G2.3381.00
27_A125_A2.3081.00
163_L212_L2.2911.00
23_V253_L2.2781.00
262_V266_A2.1661.00
19_L125_A2.1341.00
32_I414_L2.1151.00
374_Y380_D2.1131.00
52_N216_F2.0891.00
109_L159_L2.0761.00
370_K383_E2.0731.00
106_F158_G2.0701.00
122_E161_K2.0571.00
287_E374_Y2.0491.00
396_T399_E2.0451.00
34_A82_I2.0361.00
31_I124_V2.0361.00
106_F120_V2.0291.00
109_L208_V2.0181.00
328_D333_A2.0151.00
22_K253_L1.9461.00
289_E372_T1.9341.00
419_N422_E1.9221.00
405_L411_K1.9021.00
279_N282_D1.9001.00
20_S23_V1.8961.00
27_A121_I1.8701.00
404_Y408_K1.8691.00
156_A173_A1.8631.00
16_Y118_K1.8441.00
15_N18_N1.8401.00
405_L414_L1.8381.00
140_L149_T1.8271.00
275_S382_I1.8201.00
16_Y24_I1.7861.00
411_K415_N1.7801.00
375_T379_K1.7761.00
157_A174_I1.7711.00
288_V320_L1.7631.00
12_S167_E1.7521.00
289_E354_I1.7501.00
103_I124_V1.7301.00
176_L195_W1.6981.00
109_L163_L1.6841.00
326_K341_N1.6331.00
82_I101_D1.6201.00
134_L153_V1.6141.00
10_F250_D1.6091.00
24_I28_K1.5901.00
62_P74_A1.5891.00
19_L24_I1.5771.00
270_V323_T1.5741.00
326_K338_M1.5651.00
39_R408_K1.5611.00
178_L224_P1.5491.00
163_L211_A1.5461.00
119_D161_K1.5391.00
90_T256_S1.5351.00
153_V174_I1.5341.00
32_I417_L1.5261.00
318_Y348_M1.5131.00
127_G158_G1.5011.00
17_Q118_K1.5001.00
401_E418_W1.4981.00
71_P75_A1.4841.00
416_I423_L1.4681.00
325_I344_I1.4681.00
47_H81_L1.4661.00
119_D122_E1.4550.99
272_A384_V1.4530.99
401_E414_L1.4530.99
38_A82_I1.4340.99
24_I122_E1.4340.99
160_A165_L1.4280.99
56_Y216_F1.4280.99
163_L215_K1.4270.99
299_A317_P1.4230.99
71_P112_L1.4210.99
286_I373_I1.4190.99
372_T380_D1.4060.99
346_N349_K1.4020.99
186_E227_G1.3990.99
322_Y333_A1.3910.99
278_V375_T1.3890.99
54_V77_Y1.3880.99
271_E388_R1.3800.99
205_R209_F1.3780.99
109_L113_F1.3770.99
64_L69_A1.3740.99
156_A207_A1.3700.99
401_E405_L1.3650.99
10_F247_L1.3550.99
176_L214_A1.3440.99
63_L68_N1.3400.99
305_N349_K1.3350.99
130_V157_A1.3350.99
8_A12_S1.3300.99
197_A313_D1.3290.99
106_F159_L1.3260.99
11_V170_T1.3220.99
117_G420_M1.3210.99
74_A78_N1.3140.99
11_V157_A1.2990.99
263_E314_H1.2980.99
20_S250_D1.2940.99
375_T378_G1.2870.99
272_A371_V1.2800.99
16_Y19_L1.2780.99
109_L162_M1.2780.99
259_K395_M1.2750.99
325_I347_L1.2730.99
345_R348_M1.2690.99
29_R400_V1.2610.99
270_V319_I1.2550.98
31_I121_I1.2520.98
310_E313_D1.2510.98
48_L52_N1.2400.98
415_N419_N1.2280.98
165_L214_A1.2280.98
330_W333_A1.2270.98
30_R257_L1.2210.98
24_I121_I1.2180.98
202_D205_R1.2130.98
110_G120_V1.2090.98
90_T264_Y1.2020.98
165_L169_S1.2020.98
18_N122_E1.1990.98
120_V425_V1.1850.98
266_A319_I1.1840.98
12_S170_T1.1840.98
307_T311_T1.1820.98
405_L410_R1.1800.98
276_F373_I1.1730.98
115_L162_M1.1660.98
8_A171_V1.1630.97
146_D199_A1.1610.97
119_D164_K1.1610.97
370_K381_T1.1580.97
79_T199_A1.1500.97
65_F107_L1.1470.97
165_L173_A1.1460.97
281_D376_T1.1370.97
106_F124_V1.1340.97
262_V334_Y1.1260.97
251_G254_K1.1240.97
122_E126_I1.1160.97
319_I334_Y1.1150.97
4_A171_V1.1150.97
389_G394_P1.1140.97
70_T73_F1.1080.97
38_A65_F1.1070.97
213_L218_M1.1050.97
386_N392_N1.1030.97
26_E29_R1.1030.97
246_R249_D1.0980.96
41_A81_L1.0980.96
159_L211_A1.0980.96
35_I417_L1.0900.96
273_G373_I1.0870.96
5_E167_E1.0820.96
105_A155_A1.0820.96
413_E417_L1.0740.96
355_E360_T1.0690.96
120_V124_V1.0690.96
100_S103_I1.0560.96
179_V199_A1.0550.96
76_F201_A1.0510.95
69_A77_Y1.0450.95
49_V194_M1.0450.95
114_N426_K1.0430.95
105_A159_L1.0410.95
165_L215_K1.0410.95
283_I373_I1.0400.95
5_E168_K1.0400.95
178_L184_L1.0340.95
100_S128_Y1.0340.95
91_Y94_K1.0260.95
83_R88_N1.0250.95
148_V183_A1.0230.95
65_F78_N1.0220.95
62_P111_S1.0170.95
155_A207_A1.0120.94
398_A401_E1.0080.94
202_D206_K1.0070.94
91_Y251_G1.0060.94
304_W317_P1.0040.94
32_I401_E1.0020.94
179_V195_W1.0020.94
64_L77_Y1.0020.94
5_E171_V0.9950.94
157_A170_T0.9940.94
281_D343_K0.9870.94
86_D196_K0.9870.94
47_H77_Y0.9860.94
169_S172_N0.9850.94
50_N80_F0.9850.94
172_N219_T0.9800.93
260_Y271_E0.9750.93
424_K427_E0.9740.93
84_Y197_A0.9730.93
273_G324_L0.9600.93
259_K264_Y0.9580.93
49_V218_M0.9570.93
270_V329_F0.9480.92
36_A407_L0.9470.92
53_V216_F0.9470.92
113_F215_K0.9460.92
159_L207_A0.9450.92
316_L353_V0.9440.92
16_Y121_I0.9420.92
172_N214_A0.9280.91
256_S264_Y0.9280.91
184_L234_V0.9250.91
33_D403_K0.9240.91
152_Q207_A0.9220.91
153_V178_L0.9190.91
292_E360_T0.9180.91
112_L212_L0.9170.91
270_V273_G0.9170.91
402_E406_R0.9130.91
161_K170_T0.9090.90
51_K67_G0.9060.90
25_H29_R0.9030.90
172_N220_S0.9000.90
133_K246_R0.8950.90
24_I125_A0.8950.90
165_L211_A0.8930.90
94_K97_L0.8920.90
24_I118_K0.8910.90
76_F79_T0.8870.89
115_L120_V0.8840.89
264_Y267_E0.8840.89
261_P329_F0.8810.89
356_D359_Y0.8780.89
419_N427_E0.8760.89
75_A108_S0.8750.89
304_W349_K0.8750.89
305_N345_R0.8630.88
261_P333_A0.8610.88
73_F77_Y0.8570.88
358_K361_S0.8560.88
80_F201_A0.8550.88
10_F129_E0.8510.87
375_T380_D0.8500.87
140_L144_G0.8460.87
272_A382_I0.8450.87
108_S111_S0.8440.87
288_V351_I0.8440.87
165_L170_T0.8430.87
269_V320_L0.8390.87
71_P108_S0.8340.86
318_Y322_Y0.8330.86
283_I324_L0.8330.86
5_E9_E0.8300.86
143_K237_K0.8290.86
11_V160_A0.8230.86
212_L216_F0.8220.85
167_E171_V0.8190.85
156_A211_A0.8110.85
282_D377_K0.8100.85
412_E416_I0.8100.85
11_V161_K0.8090.85
92_L264_Y0.8080.84
34_A103_I0.8070.84
31_I103_I0.8070.84
265_H363_Y0.8030.84
411_K414_L0.8010.84
194_M218_M0.7990.84
5_E222_S0.7980.84
75_A105_A0.7980.84
321_A351_I0.7970.84
284_I350_K0.7960.84
324_L347_L0.7960.84
257_L400_V0.7910.83
194_M219_T0.7910.83
126_I161_K0.7880.83
397_D418_W0.7870.83
242_T245_N0.7870.83
118_K421_E0.7860.83
72_D212_L0.7850.83
269_V316_L0.7830.83
179_V184_L0.7830.83
169_S215_K0.7790.82
49_V52_N0.7750.82
91_Y135_C0.7740.82
16_Y122_E0.7740.82
11_V174_I0.7710.82
157_A160_A0.7700.82
36_A39_R0.7690.81
288_V316_L0.7690.81
21_E25_H0.7660.81
105_A158_G0.7640.81
141_R188_R0.7600.81
117_G120_V0.7590.81
78_N111_S0.7590.81
83_R199_A0.7580.80
78_N108_S0.7580.80
110_G113_F0.7580.80
244_F247_L0.7570.80
83_R313_D0.7570.80
88_N196_K0.7550.80
43_N48_L0.7550.80
303_K311_T0.7520.80
388_R393_N0.7510.80
277_N327_K0.7460.79
146_D196_K0.7450.79
196_K199_A0.7440.79
171_V222_S0.7440.79
61_V71_P0.7420.79
322_Y344_I0.7390.79
292_E296_T0.7390.79
415_N418_W0.7350.78
321_A347_L0.7350.78
86_D314_H0.7340.78
261_P407_L0.7340.78
195_W199_A0.7330.78
41_A84_Y0.7320.78
79_T201_A0.7320.78
62_P78_N0.7310.78
343_K346_N0.7300.78
269_V288_V0.7300.78
51_K77_Y0.7270.78
94_K135_C0.7270.78
69_A73_F0.7250.77
182_I235_V0.7240.77
288_V371_V0.7240.77
22_K25_H0.7200.77
72_D205_R0.7200.77
286_I347_L0.7190.77
4_A225_F0.7170.77
326_K344_I0.7170.77
89_D100_S0.7150.77
206_K210_G0.7120.76
52_N55_T0.7110.76
265_H291_Y0.7110.76
40_G85_L0.7070.76
186_E223_K0.7070.76
405_L409_G0.7010.75
325_I343_K0.7010.75
102_M127_G0.7000.75
113_F162_M0.7000.75
377_K380_D0.6970.75
342_E357_E0.6960.75
323_T329_F0.6940.74
260_Y388_R0.6930.74
27_A124_V0.6930.74
358_K362_I0.6920.74
291_Y294_A0.6910.74
90_T367_L0.6900.74
83_R151_L0.6880.74
83_R146_D0.6850.73
326_K343_K0.6840.73
212_L215_K0.6820.73
273_G323_T0.6800.73
164_K167_E0.6800.73
157_A173_A0.6800.73
249_D254_K0.6670.71
188_R314_H0.6660.71
338_M341_N0.6650.71
31_I120_V0.6650.71
320_L324_L0.6650.71
40_G331_L0.6620.71
25_H28_K0.6590.71
29_R418_W0.6590.71
221_P227_G0.6580.70
228_R233_N0.6570.70
247_L250_D0.6570.70
106_F153_V0.6570.70
278_V282_D0.6560.70
414_L417_L0.6550.70
102_M106_F0.6540.70
136_D251_G0.6530.70
141_R148_V0.6530.70
26_E30_R0.6530.70
283_I286_I0.6520.70
85_L263_E0.6500.69
76_F205_R0.6490.69
273_G371_V0.6490.69
151_L183_A0.6490.69
280_V325_I0.6480.69
46_P84_Y0.6480.69
286_I351_I0.6470.69
152_Q181_N0.6440.69
185_R188_R0.6430.69
388_R396_T0.6430.69
270_V274_K0.6410.68
295_K353_V0.6400.68
83_R101_D0.6370.68
423_L429_V0.6370.68
220_S313_D0.6330.67
397_D401_E0.6310.67
87_F261_P0.6310.67
4_A175_S0.6310.67
322_Y326_K0.6300.67
148_V151_L0.6280.67
146_D179_V0.6270.67
129_E133_K0.6260.67
225_F232_V0.6230.66
290_T353_V0.6220.66
419_N423_L0.6220.66
99_P132_V0.6200.66
340_F345_R0.6190.66
90_T97_L0.6180.66
61_V112_L0.6170.65
416_I419_N0.6160.65
106_F127_G0.6160.65
292_E355_E0.6150.65
201_A204_S0.6140.65
34_A104_G0.6130.65
91_Y180_P0.6120.65
357_E361_S0.6110.65
193_S197_A0.6090.64
329_F334_Y0.6080.64
34_A38_A0.6080.64
34_A100_S0.6070.64
128_Y255_T0.6060.64
89_D196_K0.6060.64
50_N76_F0.6060.64
62_P71_P0.6060.64
140_L150_F0.6040.64
83_R200_A0.6040.64
37_V87_F0.6030.64
19_L122_E0.6030.64
312_A339_I0.6030.64
23_V26_E0.6030.64
324_L375_T0.6030.64
413_E416_I0.6020.64
410_R413_E0.6020.64
115_L119_D0.6020.64
8_A157_A0.6020.64
47_H84_Y0.6010.63
282_D380_D0.6010.63
8_A170_T0.6010.63
105_A208_V0.6000.63
129_E250_D0.5980.63
45_P48_L0.5980.63
83_R196_K0.5980.63
192_L197_A0.5970.63
265_H294_A0.5960.63
87_F407_L0.5940.63
116_E424_K0.5930.62
196_K313_D0.5930.62
140_L147_H0.5930.62
58_L70_T0.5930.62
366_E385_R0.5930.62
389_G395_M0.5920.62
412_E415_N0.5900.62
172_N222_S0.5900.62
63_L78_N0.5890.62
22_K391_Y0.5860.61
180_P210_G0.5860.61
423_L427_E0.5850.61
117_G423_L0.5850.61
264_Y390_Y0.5820.61
175_S179_V0.5820.61
15_N161_K0.5810.61
328_D406_R0.5800.61
366_E386_N0.5790.61
34_A257_L0.5770.60
269_V369_V0.5760.60
263_E298_I0.5750.60
79_T104_G0.5750.60
88_N183_A0.5750.60
102_M158_G0.5740.60
348_M351_I0.5740.60
12_S126_I0.5730.60
44_S47_H0.5730.60
17_Q426_K0.5730.60
118_K419_N0.5730.60
309_K339_I0.5730.60
20_S253_L0.5710.60
183_A199_A0.5710.60
328_D402_E0.5710.60
184_L224_P0.5700.59
279_N375_T0.5700.59
310_E314_H0.5690.59
145_F235_V0.5680.59
109_L212_L0.5670.59
54_V73_F0.5660.59
7_I130_V0.5650.59
29_R396_T0.5640.59
419_N426_K0.5640.59
32_I418_W0.5640.59
280_V283_I0.5640.59
188_R197_A0.5640.59
153_V177_T0.5630.58
284_I287_E0.5630.58
187_T195_W0.5620.58
99_P255_T0.5610.58
100_S299_A0.5600.58
151_L203_A0.5600.58
50_N77_Y0.5590.58
280_V324_L0.5590.58
350_K376_T0.5580.58
281_D379_K0.5570.58
243_V247_L0.5560.58
362_I366_E0.5550.57
86_D98_H0.5550.57
27_A252_I0.5540.57
138_T150_F0.5530.57
148_V196_K0.5530.57
8_A167_E0.5520.57
109_L112_L0.5520.57
322_Y329_F0.5510.57
133_K244_F0.5510.57
34_A37_V0.5500.57
298_I317_P0.5500.57
25_H418_W0.5500.57
153_V156_A0.5500.57
376_T405_L0.5490.57
141_R144_G0.5490.57
9_E15_N0.5490.57
425_V429_V0.5490.57
268_A369_V0.5490.57
280_V375_T0.5480.56
309_K336_K0.5480.56
91_Y132_V0.5470.56
83_R314_H0.5470.56
191_E222_S0.5470.56
110_G115_L0.5460.56
359_Y370_K0.5440.56
128_Y252_I0.5420.56
16_Y125_A0.5410.55
152_Q177_T0.5410.55
265_H297_I0.5410.55
55_T58_L0.5410.55
299_A353_V0.5390.55
309_K313_D0.5370.55
317_P348_M0.5370.55
91_Y97_L0.5360.55
252_I255_T0.5320.54
106_F155_A0.5320.54
30_R103_I0.5320.54
100_S261_P0.5310.54
82_I103_I0.5310.54
11_V130_V0.5300.54
196_K403_K0.5300.54
299_A304_W0.5290.54
168_K172_N0.5290.54
414_L418_W0.5290.54
290_T294_A0.5280.54
298_I314_H0.5280.54
346_N351_I0.5280.54
399_E402_E0.5270.54
351_I371_V0.5270.54
129_E252_I0.5260.53
126_I157_A0.5260.53
149_T182_I0.5260.53
83_R182_I0.5260.53
76_F80_F0.5260.53
282_D379_K0.5260.53
30_R255_T0.5250.53
261_P330_W0.5230.53
187_T193_S0.5230.53
394_P399_E0.5210.53
28_K117_G0.5210.53
79_T204_S0.5210.53
384_V393_N0.5200.53
144_G148_V0.5200.53
7_I174_I0.5200.53
83_R183_A0.5200.53
186_E189_S0.5200.53
220_S224_P0.5190.52
48_L51_K0.5180.52
86_D100_S0.5170.52
283_I375_T0.5170.52
176_L210_G0.5160.52
64_L67_G0.5160.52
153_V182_I0.5150.52
8_A156_A0.5140.52
316_L320_L0.5140.52
412_E427_E0.5140.52
83_R197_A0.5130.52
18_N161_K0.5120.51
329_F333_A0.5110.51
37_V86_D0.5090.51
86_D90_T0.5090.51
144_G196_K0.5080.51
83_R150_F0.5070.51
335_D338_M0.5070.51
175_S222_S0.5070.51
299_A303_K0.5070.51
423_L428_I0.5070.51
188_R297_I0.5070.51
154_G158_G0.5060.51
45_P49_V0.5060.51
28_K121_I0.5050.51
271_E275_S0.5050.51
105_A109_L0.5050.51
92_L263_E0.5040.50
37_V41_A0.5040.50
147_H265_H0.5040.50
187_T221_P0.5030.50
88_N151_L0.5030.50
134_L225_F0.5030.50
176_L218_M0.5030.50
352_T374_Y0.5010.50
135_C185_R0.5010.50
31_I420_M0.5010.50
6_K9_E0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hp0A 2 0.9724 100 0.118 Contact Map
1szqA 2 0.9862 100 0.162 Contact Map
4rqoA 2 0.5701 97.3 0.935 Contact Map
1djxA 1 0.1793 19.2 0.975 Contact Map
2jqtA 1 0.0943 12 0.977 Contact Map
3ipzA 3 0.2391 11.7 0.977 Contact Map
3dwlG 1 0.1655 11.7 0.977 Contact Map
3m1dA 1 0.1655 10.1 0.978 Contact Map
1dd4C 7 0.0644 9.8 0.978 Contact Map
1ti6A 3 0.1839 9.5 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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