Q97VN2 - SULSO - GREMLIN Contacts

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Q97VN2 - Methylisocitrate lyase

UniProt:	Q97VN2	Sequences: MSQVLREADFLMVPGVFNPFTAILAKKVGFKAVYLSGAALTSSYGLPDIGLITLDEVAEMIRRIKEVVDIPIIVDSDTGFGEAMNVYRTVRVLEKAGADAIQIEDQRMPKKCGHLEGKEVVEPLEMVQKIKAALKARRDALIIARVDSRGVIGLDDAIERAKIYLEAGADIIFPEALTSKEEFTKFAKEVKAPLLANMTEFGKTPYIKAQEFKEMGYKYVIFPVTIFRVAAKAMKDALEVLLREGTQINLLDKMINRQQQYEIIDYFFYERLDKELGSIKLVRKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	285 (242)
Sequences:	3973 (2193)
Seq/√Len:	140.9

ECOLI - PRPB
BACSU - PRPB
SULSO - Q97VN2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
36_S	39_A	3.522	1.00
123_P	163_I	3.062	1.00
165_L	192_A	2.829	1.00
185_K	189_E	2.767	1.00
26_K	69_D	2.734	1.00
61_I	98_A	2.715	1.00
187_A	194_L	2.612	1.00
149_R	182_E	2.528	1.00
180_K	211_E	2.493	1.00
179_S	182_E	2.385	1.00
184_T	188_K	2.371	1.00
10_F	213_K	2.321	1.00
156_D	159_E	2.317	1.00
211_E	214_E	2.287	1.00
239_E	243_R	2.281	1.00
180_K	215_M	2.259	1.00
240_V	244_E	2.221	1.00
141_L	171_I	2.220	1.00
177_L	186_F	2.211	1.00
152_I	156_D	2.183	1.00
16_V	25_A	2.176	1.00
208_K	211_E	2.130	1.00
134_L	137_R	1.969	1.00
54_L	92_V	1.962	1.00
65_K	72_I	1.959	1.00
122_E	125_E	1.955	1.00
76_S	101_I	1.951	1.00
183_F	196_A	1.929	1.00
74_V	93_L	1.852	1.00
27_K	235_K	1.845	1.00
123_P	127_V	1.782	1.00
16_V	33_V	1.782	1.00
127_V	163_I	1.754	1.00
26_K	70_I	1.751	1.00
154_L	158_I	1.747	1.00
81_G	85_N	1.669	1.00
86_V	133_A	1.662	1.00
232_K	236_D	1.637	1.00
155_D	185_K	1.601	1.00
8_A	218_K	1.601	1.00
13_V	32_A	1.601	1.00
25_A	238_L	1.577	1.00
226_I	238_L	1.560	1.00
210_Q	214_E	1.550	1.00
94_E	138_R	1.526	1.00
181_E	184_T	1.523	1.00
158_I	162_K	1.521	1.00
100_A	143_I	1.517	1.00
154_L	185_K	1.512	1.00
73_I	143_I	1.511	1.00
9_D	213_K	1.506	1.00
155_D	159_E	1.503	1.00
162_K	189_E	1.498	1.00
90_V	101_I	1.476	1.00
161_A	172_I	1.466	1.00
165_L	191_K	1.458	1.00
161_A	190_V	1.456	1.00
68_V	72_I	1.456	1.00
123_P	164_Y	1.452	1.00
210_Q	213_K	1.431	1.00
90_V	133_A	1.417	1.00
196_A	212_F	1.410	1.00
74_V	98_A	1.410	1.00
10_F	220_V	1.406	1.00
94_E	137_R	1.405	1.00
244_E	249_N	1.395	1.00
235_K	239_E	1.395	1.00
187_A	217_Y	1.388	1.00
53_T	56_E	1.383	1.00
30_F	242_L	1.378	1.00
161_A	174_P	1.375	1.00
126_M	164_Y	1.372	1.00
107_R	119_E	1.351	1.00
180_K	184_T	1.344	1.00
123_P	159_E	1.339	1.00
76_S	93_L	1.332	1.00
148_S	157_A	1.327	1.00
100_A	141_L	1.315	1.00
121_V	125_E	1.254	1.00
25_A	33_V	1.243	1.00
207_I	215_M	1.240	1.00
24_L	238_L	1.226	1.00
93_L	101_I	1.223	1.00
21_T	234_M	1.216	1.00
101_I	140_A	1.204	1.00
130_I	169_A	1.204	1.00
31_K	242_L	1.201	1.00
172_I	192_A	1.199	1.00
61_I	74_V	1.194	1.00
230_A	233_A	1.183	1.00
7_E	218_K	1.174	1.00
94_E	140_A	1.173	1.00
38_A	42_S	1.168	1.00
150_G	153_G	1.164	0.99
229_V	237_A	1.156	0.99
33_V	68_V	1.156	0.99
125_E	128_Q	1.150	0.99
57_V	93_L	1.149	0.99
121_V	129_K	1.141	0.99
174_P	186_F	1.138	0.99
200_E	225_T	1.125	0.99
76_S	89_T	1.122	0.99
134_L	138_R	1.120	0.99
194_L	217_Y	1.119	0.99
34_Y	102_Q	1.111	0.99
134_L	142_I	1.110	0.99
57_V	80_F	1.104	0.99
162_K	166_E	1.099	0.99
159_E	162_K	1.096	0.99
230_A	234_M	1.089	0.99
23_I	27_K	1.081	0.99
158_I	190_V	1.080	0.99
195_L	221_I	1.066	0.99
103_I	133_A	1.054	0.99
40_L	60_M	1.049	0.99
137_R	142_I	1.041	0.99
13_V	73_I	1.039	0.99
130_I	167_A	1.038	0.99
149_R	154_L	1.038	0.99
13_V	219_Y	1.034	0.99
59_E	62_R	1.030	0.99
229_V	233_A	1.027	0.99
159_E	163_I	1.021	0.99
186_F	190_V	1.018	0.99
66_E	95_K	0.998	0.98
44_Y	63_R	0.994	0.98
17_F	21_T	0.994	0.98
28_V	239_E	0.990	0.98
144_A	169_A	0.990	0.98
209_A	220_V	0.988	0.98
54_L	89_T	0.985	0.98
7_E	31_K	0.976	0.98
12_M	209_A	0.975	0.98
4_V	31_K	0.964	0.98
35_L	61_I	0.961	0.98
55_D	59_E	0.960	0.98
172_I	190_V	0.956	0.98
184_T	215_M	0.955	0.98
187_A	218_K	0.955	0.98
154_L	189_E	0.951	0.98
162_K	191_K	0.948	0.98
37_G	77_D	0.945	0.98
18_N	21_T	0.943	0.98
3_Q	6_R	0.940	0.98
73_I	219_Y	0.936	0.98
23_I	26_K	0.928	0.97
35_L	72_I	0.912	0.97
78_T	121_V	0.910	0.97
20_F	227_F	0.908	0.97
175_E	197_N	0.908	0.97
4_V	7_E	0.905	0.97
8_A	213_K	0.899	0.97
126_M	129_K	0.898	0.97
14_P	30_F	0.898	0.97
127_V	164_Y	0.897	0.97
88_R	92_V	0.897	0.97
143_I	171_I	0.896	0.97
148_S	156_D	0.892	0.97
102_Q	143_I	0.890	0.97
165_L	190_V	0.887	0.97
60_M	63_R	0.885	0.97
102_Q	147_D	0.883	0.97
236_D	239_E	0.881	0.97
62_R	95_K	0.875	0.96
34_Y	221_I	0.872	0.96
46_L	53_T	0.869	0.96
233_A	237_A	0.867	0.96
240_V	246_T	0.866	0.96
18_N	43_S	0.864	0.96
81_G	89_T	0.863	0.96
47_P	51_L	0.862	0.96
127_V	167_A	0.862	0.96
149_R	157_A	0.843	0.96
162_K	190_V	0.842	0.96
46_L	56_E	0.840	0.95
13_V	143_I	0.838	0.95
171_I	219_Y	0.829	0.95
241_L	247_Q	0.828	0.95
127_V	131_K	0.827	0.95
83_A	125_E	0.824	0.95
15_G	34_Y	0.823	0.95
130_I	134_L	0.821	0.95
163_I	166_E	0.821	0.95
3_Q	7_E	0.819	0.95
182_E	185_K	0.819	0.95
38_A	224_V	0.815	0.95
146_V	161_A	0.808	0.94
232_K	235_K	0.807	0.94
114_H	197_N	0.800	0.94
66_E	92_V	0.797	0.94
238_L	242_L	0.796	0.94
42_S	227_F	0.793	0.94
2_S	170_D	0.784	0.94
197_N	224_V	0.779	0.93
6_R	9_D	0.777	0.93
123_P	126_M	0.775	0.93
178_T	182_E	0.775	0.93
99_D	139_D	0.775	0.93
165_L	172_I	0.774	0.93
226_I	234_M	0.773	0.93
40_L	61_I	0.771	0.93
180_K	207_I	0.767	0.93
124_L	128_Q	0.766	0.93
187_A	215_M	0.766	0.93
2_S	5_L	0.765	0.93
225_T	237_A	0.764	0.93
61_I	93_L	0.761	0.92
61_I	72_I	0.761	0.92
173_F	197_N	0.761	0.92
36_S	224_V	0.760	0.92
24_L	28_V	0.758	0.92
126_M	130_I	0.756	0.92
137_R	140_A	0.754	0.92
183_F	215_M	0.751	0.92
143_I	219_Y	0.750	0.92
25_A	226_I	0.748	0.92
92_V	95_K	0.747	0.92
86_V	129_K	0.746	0.92
62_R	96_A	0.745	0.92
35_L	40_L	0.744	0.92
131_K	135_K	0.742	0.92
224_V	227_F	0.737	0.91
134_L	170_D	0.736	0.91
211_E	215_M	0.736	0.91
50_G	78_T	0.734	0.91
15_G	221_I	0.732	0.91
89_T	93_L	0.729	0.91
185_K	188_K	0.729	0.91
114_H	118_K	0.729	0.91
26_K	68_V	0.726	0.91
87_Y	135_K	0.725	0.91
35_L	64_I	0.725	0.91
11_L	32_A	0.721	0.90
55_D	92_V	0.718	0.90
9_D	31_K	0.718	0.90
82_E	125_E	0.717	0.90
4_V	9_D	0.716	0.90
62_R	66_E	0.716	0.90
2_S	141_L	0.715	0.90
161_A	186_F	0.710	0.90
184_T	211_E	0.708	0.90
38_A	228_R	0.705	0.89
23_I	67_V	0.704	0.89
120_V	148_S	0.702	0.89
162_K	192_A	0.701	0.89
146_V	174_P	0.697	0.89
32_A	71_P	0.690	0.88
123_P	156_D	0.687	0.88
158_I	189_E	0.685	0.88
22_A	68_V	0.682	0.88
57_V	74_V	0.679	0.87
122_E	127_V	0.678	0.87
82_E	109_P	0.677	0.87
86_V	132_A	0.672	0.87
154_L	182_E	0.671	0.87
118_K	197_N	0.671	0.87
57_V	61_I	0.670	0.87
157_A	186_F	0.670	0.87
128_Q	131_K	0.668	0.87
155_D	189_E	0.667	0.87
58_A	92_V	0.667	0.87
60_M	64_I	0.666	0.86
20_F	231_A	0.662	0.86
93_L	98_A	0.661	0.86
114_H	175_E	0.661	0.86
183_F	217_Y	0.659	0.86
52_I	57_V	0.659	0.86
24_L	231_A	0.649	0.85
225_T	247_Q	0.649	0.85
90_V	137_R	0.645	0.85
19_P	67_V	0.644	0.85
164_Y	167_A	0.643	0.85
100_A	171_I	0.634	0.84
163_I	167_A	0.633	0.84
7_E	10_F	0.630	0.83
65_K	99_D	0.629	0.83
209_A	213_K	0.629	0.83
151_V	156_D	0.628	0.83
236_D	240_V	0.628	0.83
83_A	132_A	0.622	0.83
83_A	128_Q	0.621	0.82
82_E	128_Q	0.618	0.82
76_S	90_V	0.618	0.82
83_A	87_Y	0.618	0.82
207_I	212_F	0.617	0.82
148_S	153_G	0.617	0.82
62_R	92_V	0.614	0.82
171_I	192_A	0.614	0.82
150_G	176_A	0.610	0.81
29_G	70_I	0.610	0.81
240_V	249_N	0.608	0.81
87_Y	132_A	0.608	0.81
44_Y	52_I	0.607	0.81
2_S	6_R	0.606	0.81
133_A	136_A	0.604	0.81
122_E	163_I	0.599	0.80
19_P	63_R	0.598	0.80
91_R	95_K	0.597	0.80
90_V	94_E	0.596	0.80
40_L	57_V	0.593	0.79
195_L	219_Y	0.591	0.79
82_E	121_V	0.591	0.79
86_V	103_I	0.591	0.79
118_K	176_A	0.589	0.79
181_E	243_R	0.584	0.78
43_S	60_M	0.584	0.78
39_A	227_F	0.583	0.78
65_K	98_A	0.583	0.78
9_D	218_K	0.577	0.78
102_Q	221_I	0.575	0.77
22_A	64_I	0.573	0.77
64_I	72_I	0.572	0.77
50_G	80_F	0.569	0.77
65_K	96_A	0.568	0.77
149_R	178_T	0.566	0.76
5_L	10_F	0.563	0.76
78_T	108_M	0.563	0.76
54_L	58_A	0.560	0.76
94_E	139_D	0.558	0.75
199_T	228_R	0.557	0.75
222_F	226_I	0.556	0.75
8_A	31_K	0.553	0.75
106_Q	147_D	0.546	0.74
115_L	223_P	0.543	0.73
208_K	246_T	0.543	0.73
82_E	129_K	0.540	0.73
4_V	10_F	0.540	0.73
12_M	222_F	0.538	0.73
233_A	236_D	0.538	0.73
12_M	242_L	0.538	0.73
159_E	188_K	0.537	0.72
54_L	93_L	0.536	0.72
90_V	138_R	0.536	0.72
162_K	165_L	0.535	0.72
183_F	187_A	0.532	0.72
157_A	174_P	0.532	0.72
132_A	135_K	0.530	0.71
102_Q	171_I	0.528	0.71
19_P	64_I	0.527	0.71
19_P	60_M	0.524	0.71
132_A	136_A	0.522	0.70
121_V	126_M	0.521	0.70
78_T	106_Q	0.519	0.70
109_P	129_K	0.518	0.70
125_E	130_I	0.515	0.69
106_Q	146_V	0.515	0.69
147_D	173_F	0.513	0.69
78_T	125_E	0.513	0.69
38_A	227_F	0.513	0.69
4_V	8_A	0.509	0.68
15_G	36_S	0.509	0.68
246_T	249_N	0.508	0.68
131_K	159_E	0.507	0.68
118_K	150_G	0.507	0.68
41_T	52_I	0.506	0.68
128_Q	132_A	0.506	0.68
34_Y	175_E	0.505	0.68
30_F	238_L	0.504	0.68
76_S	103_I	0.503	0.68
224_V	228_R	0.502	0.67
11_L	219_Y	0.501	0.67
59_E	63_R	0.501	0.67
4_V	11_L	0.500	0.67

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fa4A	5	0.9789	100	0.187	Contact Map
3lyeA	4	0.9404	100	0.194	Contact Map
2hjpA	4	0.9474	100	0.198	Contact Map
1s2wA	2	0.8526	100	0.198	Contact Map
3eooA	4	0.9825	100	0.203	Contact Map
1zlpA	4	0.9754	100	0.203	Contact Map
1xg4A	4	0.9649	100	0.207	Contact Map
4iqdA	4	0.9789	100	0.218	Contact Map
1f8mA	4	0.9825	100	0.224	Contact Map
3eolA	4	0.8596	100	0.231	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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