GREMLIN Database
Q97VN2 - Methylisocitrate lyase
UniProt: Q97VN2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (242)
Sequences: 3973 (2193)
Seq/√Len: 140.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_S39_A3.5221.00
123_P163_I3.0621.00
165_L192_A2.8291.00
185_K189_E2.7671.00
26_K69_D2.7341.00
61_I98_A2.7151.00
187_A194_L2.6121.00
149_R182_E2.5281.00
180_K211_E2.4931.00
179_S182_E2.3851.00
184_T188_K2.3711.00
10_F213_K2.3211.00
156_D159_E2.3171.00
211_E214_E2.2871.00
239_E243_R2.2811.00
180_K215_M2.2591.00
240_V244_E2.2211.00
141_L171_I2.2201.00
177_L186_F2.2111.00
152_I156_D2.1831.00
16_V25_A2.1761.00
208_K211_E2.1301.00
134_L137_R1.9691.00
54_L92_V1.9621.00
65_K72_I1.9591.00
122_E125_E1.9551.00
76_S101_I1.9511.00
183_F196_A1.9291.00
74_V93_L1.8521.00
27_K235_K1.8451.00
123_P127_V1.7821.00
16_V33_V1.7821.00
127_V163_I1.7541.00
26_K70_I1.7511.00
154_L158_I1.7471.00
81_G85_N1.6691.00
86_V133_A1.6621.00
232_K236_D1.6371.00
155_D185_K1.6011.00
8_A218_K1.6011.00
13_V32_A1.6011.00
25_A238_L1.5771.00
226_I238_L1.5601.00
210_Q214_E1.5501.00
94_E138_R1.5261.00
181_E184_T1.5231.00
158_I162_K1.5211.00
100_A143_I1.5171.00
154_L185_K1.5121.00
73_I143_I1.5111.00
9_D213_K1.5061.00
155_D159_E1.5031.00
162_K189_E1.4981.00
90_V101_I1.4761.00
161_A172_I1.4661.00
165_L191_K1.4581.00
161_A190_V1.4561.00
68_V72_I1.4561.00
123_P164_Y1.4521.00
210_Q213_K1.4311.00
90_V133_A1.4171.00
196_A212_F1.4101.00
74_V98_A1.4101.00
10_F220_V1.4061.00
94_E137_R1.4051.00
244_E249_N1.3951.00
235_K239_E1.3951.00
187_A217_Y1.3881.00
53_T56_E1.3831.00
30_F242_L1.3781.00
161_A174_P1.3751.00
126_M164_Y1.3721.00
107_R119_E1.3511.00
180_K184_T1.3441.00
123_P159_E1.3391.00
76_S93_L1.3321.00
148_S157_A1.3271.00
100_A141_L1.3151.00
121_V125_E1.2541.00
25_A33_V1.2431.00
207_I215_M1.2401.00
24_L238_L1.2261.00
93_L101_I1.2231.00
21_T234_M1.2161.00
101_I140_A1.2041.00
130_I169_A1.2041.00
31_K242_L1.2011.00
172_I192_A1.1991.00
61_I74_V1.1941.00
230_A233_A1.1831.00
7_E218_K1.1741.00
94_E140_A1.1731.00
38_A42_S1.1681.00
150_G153_G1.1640.99
229_V237_A1.1560.99
33_V68_V1.1560.99
125_E128_Q1.1500.99
57_V93_L1.1490.99
121_V129_K1.1410.99
174_P186_F1.1380.99
200_E225_T1.1250.99
76_S89_T1.1220.99
134_L138_R1.1200.99
194_L217_Y1.1190.99
34_Y102_Q1.1110.99
134_L142_I1.1100.99
57_V80_F1.1040.99
162_K166_E1.0990.99
159_E162_K1.0960.99
230_A234_M1.0890.99
23_I27_K1.0810.99
158_I190_V1.0800.99
195_L221_I1.0660.99
103_I133_A1.0540.99
40_L60_M1.0490.99
137_R142_I1.0410.99
13_V73_I1.0390.99
130_I167_A1.0380.99
149_R154_L1.0380.99
13_V219_Y1.0340.99
59_E62_R1.0300.99
229_V233_A1.0270.99
159_E163_I1.0210.99
186_F190_V1.0180.99
66_E95_K0.9980.98
44_Y63_R0.9940.98
17_F21_T0.9940.98
28_V239_E0.9900.98
144_A169_A0.9900.98
209_A220_V0.9880.98
54_L89_T0.9850.98
7_E31_K0.9760.98
12_M209_A0.9750.98
4_V31_K0.9640.98
35_L61_I0.9610.98
55_D59_E0.9600.98
172_I190_V0.9560.98
184_T215_M0.9550.98
187_A218_K0.9550.98
154_L189_E0.9510.98
162_K191_K0.9480.98
37_G77_D0.9450.98
18_N21_T0.9430.98
3_Q6_R0.9400.98
73_I219_Y0.9360.98
23_I26_K0.9280.97
35_L72_I0.9120.97
78_T121_V0.9100.97
20_F227_F0.9080.97
175_E197_N0.9080.97
4_V7_E0.9050.97
8_A213_K0.8990.97
126_M129_K0.8980.97
14_P30_F0.8980.97
127_V164_Y0.8970.97
88_R92_V0.8970.97
143_I171_I0.8960.97
148_S156_D0.8920.97
102_Q143_I0.8900.97
165_L190_V0.8870.97
60_M63_R0.8850.97
102_Q147_D0.8830.97
236_D239_E0.8810.97
62_R95_K0.8750.96
34_Y221_I0.8720.96
46_L53_T0.8690.96
233_A237_A0.8670.96
240_V246_T0.8660.96
18_N43_S0.8640.96
81_G89_T0.8630.96
47_P51_L0.8620.96
127_V167_A0.8620.96
149_R157_A0.8430.96
162_K190_V0.8420.96
46_L56_E0.8400.95
13_V143_I0.8380.95
171_I219_Y0.8290.95
241_L247_Q0.8280.95
127_V131_K0.8270.95
83_A125_E0.8240.95
15_G34_Y0.8230.95
130_I134_L0.8210.95
163_I166_E0.8210.95
3_Q7_E0.8190.95
182_E185_K0.8190.95
38_A224_V0.8150.95
146_V161_A0.8080.94
232_K235_K0.8070.94
114_H197_N0.8000.94
66_E92_V0.7970.94
238_L242_L0.7960.94
42_S227_F0.7930.94
2_S170_D0.7840.94
197_N224_V0.7790.93
6_R9_D0.7770.93
123_P126_M0.7750.93
178_T182_E0.7750.93
99_D139_D0.7750.93
165_L172_I0.7740.93
226_I234_M0.7730.93
40_L61_I0.7710.93
180_K207_I0.7670.93
124_L128_Q0.7660.93
187_A215_M0.7660.93
2_S5_L0.7650.93
225_T237_A0.7640.93
61_I93_L0.7610.92
61_I72_I0.7610.92
173_F197_N0.7610.92
36_S224_V0.7600.92
24_L28_V0.7580.92
126_M130_I0.7560.92
137_R140_A0.7540.92
183_F215_M0.7510.92
143_I219_Y0.7500.92
25_A226_I0.7480.92
92_V95_K0.7470.92
86_V129_K0.7460.92
62_R96_A0.7450.92
35_L40_L0.7440.92
131_K135_K0.7420.92
224_V227_F0.7370.91
134_L170_D0.7360.91
211_E215_M0.7360.91
50_G78_T0.7340.91
15_G221_I0.7320.91
89_T93_L0.7290.91
185_K188_K0.7290.91
114_H118_K0.7290.91
26_K68_V0.7260.91
87_Y135_K0.7250.91
35_L64_I0.7250.91
11_L32_A0.7210.90
55_D92_V0.7180.90
9_D31_K0.7180.90
82_E125_E0.7170.90
4_V9_D0.7160.90
62_R66_E0.7160.90
2_S141_L0.7150.90
161_A186_F0.7100.90
184_T211_E0.7080.90
38_A228_R0.7050.89
23_I67_V0.7040.89
120_V148_S0.7020.89
162_K192_A0.7010.89
146_V174_P0.6970.89
32_A71_P0.6900.88
123_P156_D0.6870.88
158_I189_E0.6850.88
22_A68_V0.6820.88
57_V74_V0.6790.87
122_E127_V0.6780.87
82_E109_P0.6770.87
86_V132_A0.6720.87
154_L182_E0.6710.87
118_K197_N0.6710.87
57_V61_I0.6700.87
157_A186_F0.6700.87
128_Q131_K0.6680.87
155_D189_E0.6670.87
58_A92_V0.6670.87
60_M64_I0.6660.86
20_F231_A0.6620.86
93_L98_A0.6610.86
114_H175_E0.6610.86
183_F217_Y0.6590.86
52_I57_V0.6590.86
24_L231_A0.6490.85
225_T247_Q0.6490.85
90_V137_R0.6450.85
19_P67_V0.6440.85
164_Y167_A0.6430.85
100_A171_I0.6340.84
163_I167_A0.6330.84
7_E10_F0.6300.83
65_K99_D0.6290.83
209_A213_K0.6290.83
151_V156_D0.6280.83
236_D240_V0.6280.83
83_A132_A0.6220.83
83_A128_Q0.6210.82
82_E128_Q0.6180.82
76_S90_V0.6180.82
83_A87_Y0.6180.82
207_I212_F0.6170.82
148_S153_G0.6170.82
62_R92_V0.6140.82
171_I192_A0.6140.82
150_G176_A0.6100.81
29_G70_I0.6100.81
240_V249_N0.6080.81
87_Y132_A0.6080.81
44_Y52_I0.6070.81
2_S6_R0.6060.81
133_A136_A0.6040.81
122_E163_I0.5990.80
19_P63_R0.5980.80
91_R95_K0.5970.80
90_V94_E0.5960.80
40_L57_V0.5930.79
195_L219_Y0.5910.79
82_E121_V0.5910.79
86_V103_I0.5910.79
118_K176_A0.5890.79
181_E243_R0.5840.78
43_S60_M0.5840.78
39_A227_F0.5830.78
65_K98_A0.5830.78
9_D218_K0.5770.78
102_Q221_I0.5750.77
22_A64_I0.5730.77
64_I72_I0.5720.77
50_G80_F0.5690.77
65_K96_A0.5680.77
149_R178_T0.5660.76
5_L10_F0.5630.76
78_T108_M0.5630.76
54_L58_A0.5600.76
94_E139_D0.5580.75
199_T228_R0.5570.75
222_F226_I0.5560.75
8_A31_K0.5530.75
106_Q147_D0.5460.74
115_L223_P0.5430.73
208_K246_T0.5430.73
82_E129_K0.5400.73
4_V10_F0.5400.73
12_M222_F0.5380.73
233_A236_D0.5380.73
12_M242_L0.5380.73
159_E188_K0.5370.72
54_L93_L0.5360.72
90_V138_R0.5360.72
162_K165_L0.5350.72
183_F187_A0.5320.72
157_A174_P0.5320.72
132_A135_K0.5300.71
102_Q171_I0.5280.71
19_P64_I0.5270.71
19_P60_M0.5240.71
132_A136_A0.5220.70
121_V126_M0.5210.70
78_T106_Q0.5190.70
109_P129_K0.5180.70
125_E130_I0.5150.69
106_Q146_V0.5150.69
147_D173_F0.5130.69
78_T125_E0.5130.69
38_A227_F0.5130.69
4_V8_A0.5090.68
15_G36_S0.5090.68
246_T249_N0.5080.68
131_K159_E0.5070.68
118_K150_G0.5070.68
41_T52_I0.5060.68
128_Q132_A0.5060.68
34_Y175_E0.5050.68
30_F238_L0.5040.68
76_S103_I0.5030.68
224_V228_R0.5020.67
11_L219_Y0.5010.67
59_E63_R0.5010.67
4_V11_L0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fa4A 5 0.9789 100 0.187 Contact Map
3lyeA 4 0.9404 100 0.194 Contact Map
2hjpA 4 0.9474 100 0.198 Contact Map
1s2wA 2 0.8526 100 0.198 Contact Map
3eooA 4 0.9825 100 0.203 Contact Map
1zlpA 4 0.9754 100 0.203 Contact Map
1xg4A 4 0.9649 100 0.207 Contact Map
4iqdA 4 0.9789 100 0.218 Contact Map
1f8mA 4 0.9825 100 0.224 Contact Map
3eolA 4 0.8596 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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