GREMLIN Database
Q97VM4 - Transcriptional activator (TenA-2)
UniProt: Q97VM4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (207)
Sequences: 2000 (1534)
Seq/√Len: 106.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_E209_Y4.0781.00
206_D210_R3.5581.00
11_F191_K3.4171.00
59_L126_V3.2081.00
155_Q159_E3.0951.00
113_Y197_A3.0071.00
122_P186_E2.9201.00
27_E30_E2.7341.00
138_M167_E2.6281.00
17_S21_R2.6111.00
97_D100_D2.5091.00
5_S178_N2.4431.00
23_P27_E2.3971.00
29_V144_L2.3781.00
196_T199_I2.2831.00
122_P125_E2.2421.00
93_E156_K2.2261.00
125_E189_K2.1911.00
68_Q179_S2.1471.00
164_E168_K2.1021.00
127_I177_V2.0781.00
203_M206_D2.0441.00
7_K187_F2.0221.00
171_R175_D2.0141.00
21_R26_L2.0111.00
58_L62_K1.9981.00
77_Q81_K1.9761.00
65_D68_Q1.9561.00
183_S186_E1.9391.00
26_L30_E1.9151.00
19_I136_I1.8751.00
108_L112_S1.8321.00
121_R125_E1.7991.00
7_K191_K1.7981.00
51_E111_T1.7661.00
104_S207_S1.6961.00
35_R39_K1.6721.00
132_P197_A1.6341.00
43_I101_Y1.6091.00
47_L103_M1.5931.00
156_K159_E1.5461.00
34_S37_K1.5401.00
40_Y104_S1.5391.00
75_H134_Y1.5311.00
145_L162_G1.4921.00
138_M170_V1.4681.00
184_E187_F1.4461.00
12_I195_R1.4391.00
13_S17_S1.4341.00
109_A200_Y1.4341.00
125_E193_H1.4221.00
135_W174_L1.4141.00
201_E204_F1.4011.00
6_E178_N1.3971.00
131_L135_W1.3741.00
141_G162_G1.3611.00
117_V193_H1.3611.00
60_A76_I1.3571.00
141_G144_L1.3551.00
7_K184_E1.3511.00
58_L118_A1.3400.99
48_Y52_F1.3350.99
112_S116_A1.3100.99
142_K167_E1.3030.99
11_F195_R1.2470.99
74_T78_D1.2330.99
134_Y173_V1.2250.99
141_G157_W1.1940.99
136_I198_S1.1750.99
54_K69_T1.1740.99
86_L160_T1.1720.99
143_E147_Q1.1610.99
166_Y170_V1.1530.98
12_I191_K1.1530.98
14_D195_R1.1490.98
133_C161_Y1.1400.98
116_A120_S1.1370.98
48_Y114_L1.1320.98
182_V190_M1.1290.98
134_Y170_V1.1240.98
63_A123_F1.1190.98
175_D179_S1.1100.98
131_L177_V1.1040.98
87_H161_Y1.0950.98
27_E37_K1.0870.98
82_V85_A1.0790.98
190_M193_H1.0760.98
123_F180_L1.0710.97
107_N207_S1.0590.97
33_L154_Y1.0580.97
67_E179_S1.0540.97
196_T200_Y1.0490.97
191_K195_R1.0450.97
38_F154_Y1.0360.97
4_N187_F1.0350.97
8_L191_K1.0330.97
10_N13_S1.0310.97
9_W13_S1.0280.97
128_S190_M1.0240.97
52_F130_V1.0190.97
118_A126_V1.0060.96
152_K159_E0.9990.96
188_N191_K0.9930.96
148_G155_Q0.9930.96
73_T77_Q0.9910.96
6_E174_L0.9670.95
124_N186_E0.9650.95
56_L134_Y0.9440.95
89_F93_E0.9380.95
35_R151_D0.9370.95
89_F156_K0.9270.94
124_N190_M0.9240.94
9_W12_I0.9210.94
134_Y169_G0.9190.94
39_K43_I0.9170.94
138_M142_K0.9130.94
144_L158_I0.9110.94
184_E188_N0.8990.93
136_I140_V0.8910.93
15_I198_S0.8840.93
55_A114_L0.8760.92
103_M111_T0.8750.92
108_L113_Y0.8740.92
48_Y133_C0.8710.92
26_L147_Q0.8670.92
199_I203_M0.8660.92
41_Y137_Y0.8650.92
70_L81_K0.8630.92
56_L130_V0.8610.92
121_R189_K0.8550.91
52_F86_L0.8530.91
87_H133_C0.8520.91
70_L74_T0.8500.91
23_P209_Y0.8410.91
74_T77_Q0.8400.91
111_T115_L0.8340.90
182_V187_F0.8330.90
58_L119_Y0.8320.90
143_E146_K0.8320.90
136_I205_W0.8310.90
140_V197_A0.8290.90
41_Y157_W0.8250.90
176_I179_S0.8210.90
68_Q176_I0.8200.90
113_Y117_V0.8130.89
38_F133_C0.8100.89
41_Y91_I0.8100.89
47_L102_E0.8040.89
84_K88_K0.7990.88
117_V129_A0.7980.88
69_T80_I0.7950.88
107_N205_W0.7930.88
59_L63_A0.7920.88
149_S155_Q0.7890.88
50_R66_E0.7880.88
83_E87_H0.7830.87
14_D17_S0.7820.87
6_E10_N0.7780.87
134_Y166_Y0.7760.87
37_K40_Y0.7750.87
75_H169_G0.7720.87
58_L61_A0.7710.87
16_Y139_K0.7680.86
87_H157_W0.7630.86
110_Y114_L0.7620.86
91_I96_L0.7590.86
68_Q123_F0.7560.85
4_N8_L0.7530.85
15_I195_R0.7480.85
18_S202_Y0.7420.84
164_E167_E0.7410.84
23_P26_L0.7380.84
140_V161_Y0.7350.84
60_A69_T0.7340.84
51_E103_M0.7290.83
9_W139_K0.7270.83
28_L158_I0.7260.83
5_S174_L0.7250.83
17_S20_L0.7170.82
128_S177_V0.7150.82
40_Y207_S0.7130.82
187_F191_K0.7090.82
78_D82_V0.7080.82
165_E168_K0.7080.82
171_R174_L0.7060.81
20_L139_K0.7040.81
206_D209_Y0.7040.81
12_I194_F0.7010.81
57_A60_A0.7000.81
20_L143_E0.6930.80
25_I136_I0.6900.80
49_L161_Y0.6900.80
45_D83_E0.6880.80
22_H206_D0.6800.79
16_Y136_I0.6800.79
71_L172_A0.6800.79
75_H78_D0.6770.79
52_F55_A0.6740.78
25_I29_V0.6740.78
152_K155_Q0.6710.78
17_S143_E0.6670.78
132_P194_F0.6660.77
200_Y203_M0.6650.77
74_T172_A0.6640.77
87_H141_G0.6620.77
57_A76_I0.6610.77
186_E189_K0.6600.77
128_S193_H0.6600.77
49_L52_F0.6570.77
45_D204_F0.6500.76
85_A88_K0.6490.76
62_K121_R0.6430.75
7_K11_F0.6400.75
160_T166_Y0.6400.75
109_A112_S0.6390.75
65_D179_S0.6380.74
36_D168_K0.6370.74
113_Y193_H0.6360.74
20_L23_P0.6360.74
44_Q107_N0.6350.74
15_I202_Y0.6350.74
83_E205_W0.6340.74
5_S135_W0.6340.74
37_K209_Y0.6330.74
57_A63_A0.6300.73
89_F92_K0.6270.73
148_G151_D0.6250.73
141_G160_T0.6240.73
18_S21_R0.6230.73
138_M171_R0.6220.73
189_K193_H0.6220.73
52_F169_G0.6220.73
110_Y205_W0.6200.72
186_E190_M0.6190.72
181_K185_E0.6170.72
77_Q80_I0.6170.72
55_A126_V0.6150.72
52_F197_A0.6110.71
27_E32_I0.6100.71
132_P161_Y0.6090.71
115_L121_R0.6060.71
51_E115_L0.6040.70
110_Y133_C0.6040.70
97_D101_Y0.6030.70
54_K61_A0.6010.70
41_Y141_G0.5990.70
129_A133_C0.5980.70
141_G161_Y0.5940.69
48_Y134_Y0.5930.69
64_E189_K0.5900.69
10_N171_R0.5870.68
71_L75_H0.5830.68
85_A89_F0.5830.68
28_L33_L0.5810.67
41_Y52_F0.5790.67
90_Y160_T0.5780.67
87_H132_P0.5780.67
14_D18_S0.5770.67
47_L51_E0.5760.67
86_L161_Y0.5760.67
62_K126_V0.5750.67
90_Y156_K0.5750.67
45_D201_E0.5700.66
78_D111_T0.5690.66
64_E67_E0.5690.66
83_E141_G0.5650.65
61_A119_Y0.5640.65
110_Y113_Y0.5630.65
39_K100_D0.5630.65
49_L87_H0.5620.65
44_Q104_S0.5620.65
56_L106_T0.5610.65
104_S107_N0.5600.65
46_Y88_K0.5600.65
16_Y19_I0.5580.64
25_I205_W0.5580.64
69_T196_T0.5550.64
16_Y20_L0.5550.64
157_W161_Y0.5540.64
135_W194_F0.5530.64
137_Y204_F0.5510.63
202_Y206_D0.5470.63
9_W135_W0.5420.62
166_Y174_L0.5410.62
15_I199_I0.5400.62
131_L174_L0.5390.62
15_I18_S0.5360.61
147_Q188_N0.5340.61
142_K145_L0.5320.61
9_W16_Y0.5290.60
111_T114_L0.5280.60
54_K58_L0.5280.60
102_E192_I0.5250.60
137_Y201_E0.5210.59
64_E179_S0.5210.59
182_V186_E0.5210.59
47_L101_Y0.5200.59
33_L38_F0.5150.58
52_F83_E0.5100.57
114_L136_I0.5090.57
114_L132_P0.5070.57
19_I134_Y0.5060.57
47_L107_N0.5060.57
35_R153_Y0.5050.57
106_T207_S0.5050.57
83_E137_Y0.5040.57
202_Y209_Y0.5040.57
54_K115_L0.5030.56
46_Y50_R0.5010.56
141_G205_W0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3no6A 4 0.9777 100 0.159 Contact Map
2qcxA 4 0.9777 100 0.169 Contact Map
2qzcA 4 0.9196 100 0.181 Contact Map
3rm5A 2 0.942 100 0.19 Contact Map
2a2mA 3 0.9152 100 0.191 Contact Map
1uddA 4 0.9286 100 0.193 Contact Map
3mvuA 4 0.9375 100 0.194 Contact Map
4fn6A 4 0.9643 100 0.199 Contact Map
2f2gA 1 0.9286 100 0.2 Contact Map
1rtwA 4 0.9241 100 0.205 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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