Q97VM4 - SULSO - GREMLIN Contacts

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Q97VM4 - Transcriptional activator (TenA-2)

UniProt:	Q97VM4	Sequences: MMENSEKLWNFISDIYSSILRHPFILELVEGILSRDKFKYYIIQDYLYLREFSKALALLAAKAEDEEQTLLFTTHIQDAIKVEKALHKFYIKEFNLDIEDYEMSPTNLAYTSYLLAVAYSRPFNEVISAVLPCYWIYMKVGKELLKQGSKDKYYQKWIETYGGEEYEKGVRAVLDIVNSLKVSEEEFNKMKIHFRTASIYEYMFWDSAYRLERFPFPTEKNKGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	224 (207)
Sequences:	2000 (1534)
Seq/√Len:	106.6

BACSU - TENA
SULSO - Q97VM4 Q97WL0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
27_E	209_Y	4.078	1.00
206_D	210_R	3.558	1.00
11_F	191_K	3.417	1.00
59_L	126_V	3.208	1.00
155_Q	159_E	3.095	1.00
113_Y	197_A	3.007	1.00
122_P	186_E	2.920	1.00
27_E	30_E	2.734	1.00
138_M	167_E	2.628	1.00
17_S	21_R	2.611	1.00
97_D	100_D	2.509	1.00
5_S	178_N	2.443	1.00
23_P	27_E	2.397	1.00
29_V	144_L	2.378	1.00
196_T	199_I	2.283	1.00
122_P	125_E	2.242	1.00
93_E	156_K	2.226	1.00
125_E	189_K	2.191	1.00
68_Q	179_S	2.147	1.00
164_E	168_K	2.102	1.00
127_I	177_V	2.078	1.00
203_M	206_D	2.044	1.00
7_K	187_F	2.022	1.00
171_R	175_D	2.014	1.00
21_R	26_L	2.011	1.00
58_L	62_K	1.998	1.00
77_Q	81_K	1.976	1.00
65_D	68_Q	1.956	1.00
183_S	186_E	1.939	1.00
26_L	30_E	1.915	1.00
19_I	136_I	1.875	1.00
108_L	112_S	1.832	1.00
121_R	125_E	1.799	1.00
7_K	191_K	1.798	1.00
51_E	111_T	1.766	1.00
104_S	207_S	1.696	1.00
35_R	39_K	1.672	1.00
132_P	197_A	1.634	1.00
43_I	101_Y	1.609	1.00
47_L	103_M	1.593	1.00
156_K	159_E	1.546	1.00
34_S	37_K	1.540	1.00
40_Y	104_S	1.539	1.00
75_H	134_Y	1.531	1.00
145_L	162_G	1.492	1.00
138_M	170_V	1.468	1.00
184_E	187_F	1.446	1.00
12_I	195_R	1.439	1.00
13_S	17_S	1.434	1.00
109_A	200_Y	1.434	1.00
125_E	193_H	1.422	1.00
135_W	174_L	1.414	1.00
201_E	204_F	1.401	1.00
6_E	178_N	1.397	1.00
131_L	135_W	1.374	1.00
141_G	162_G	1.361	1.00
117_V	193_H	1.361	1.00
60_A	76_I	1.357	1.00
141_G	144_L	1.355	1.00
7_K	184_E	1.351	1.00
58_L	118_A	1.340	0.99
48_Y	52_F	1.335	0.99
112_S	116_A	1.310	0.99
142_K	167_E	1.303	0.99
11_F	195_R	1.247	0.99
74_T	78_D	1.233	0.99
134_Y	173_V	1.225	0.99
141_G	157_W	1.194	0.99
136_I	198_S	1.175	0.99
54_K	69_T	1.174	0.99
86_L	160_T	1.172	0.99
143_E	147_Q	1.161	0.99
166_Y	170_V	1.153	0.98
12_I	191_K	1.153	0.98
14_D	195_R	1.149	0.98
133_C	161_Y	1.140	0.98
116_A	120_S	1.137	0.98
48_Y	114_L	1.132	0.98
182_V	190_M	1.129	0.98
134_Y	170_V	1.124	0.98
63_A	123_F	1.119	0.98
175_D	179_S	1.110	0.98
131_L	177_V	1.104	0.98
87_H	161_Y	1.095	0.98
27_E	37_K	1.087	0.98
82_V	85_A	1.079	0.98
190_M	193_H	1.076	0.98
123_F	180_L	1.071	0.97
107_N	207_S	1.059	0.97
33_L	154_Y	1.058	0.97
67_E	179_S	1.054	0.97
196_T	200_Y	1.049	0.97
191_K	195_R	1.045	0.97
38_F	154_Y	1.036	0.97
4_N	187_F	1.035	0.97
8_L	191_K	1.033	0.97
10_N	13_S	1.031	0.97
9_W	13_S	1.028	0.97
128_S	190_M	1.024	0.97
52_F	130_V	1.019	0.97
118_A	126_V	1.006	0.96
152_K	159_E	0.999	0.96
188_N	191_K	0.993	0.96
148_G	155_Q	0.993	0.96
73_T	77_Q	0.991	0.96
6_E	174_L	0.967	0.95
124_N	186_E	0.965	0.95
56_L	134_Y	0.944	0.95
89_F	93_E	0.938	0.95
35_R	151_D	0.937	0.95
89_F	156_K	0.927	0.94
124_N	190_M	0.924	0.94
9_W	12_I	0.921	0.94
134_Y	169_G	0.919	0.94
39_K	43_I	0.917	0.94
138_M	142_K	0.913	0.94
144_L	158_I	0.911	0.94
184_E	188_N	0.899	0.93
136_I	140_V	0.891	0.93
15_I	198_S	0.884	0.93
55_A	114_L	0.876	0.92
103_M	111_T	0.875	0.92
108_L	113_Y	0.874	0.92
48_Y	133_C	0.871	0.92
26_L	147_Q	0.867	0.92
199_I	203_M	0.866	0.92
41_Y	137_Y	0.865	0.92
70_L	81_K	0.863	0.92
56_L	130_V	0.861	0.92
121_R	189_K	0.855	0.91
52_F	86_L	0.853	0.91
87_H	133_C	0.852	0.91
70_L	74_T	0.850	0.91
23_P	209_Y	0.841	0.91
74_T	77_Q	0.840	0.91
111_T	115_L	0.834	0.90
182_V	187_F	0.833	0.90
58_L	119_Y	0.832	0.90
143_E	146_K	0.832	0.90
136_I	205_W	0.831	0.90
140_V	197_A	0.829	0.90
41_Y	157_W	0.825	0.90
176_I	179_S	0.821	0.90
68_Q	176_I	0.820	0.90
113_Y	117_V	0.813	0.89
38_F	133_C	0.810	0.89
41_Y	91_I	0.810	0.89
47_L	102_E	0.804	0.89
84_K	88_K	0.799	0.88
117_V	129_A	0.798	0.88
69_T	80_I	0.795	0.88
107_N	205_W	0.793	0.88
59_L	63_A	0.792	0.88
149_S	155_Q	0.789	0.88
50_R	66_E	0.788	0.88
83_E	87_H	0.783	0.87
14_D	17_S	0.782	0.87
6_E	10_N	0.778	0.87
134_Y	166_Y	0.776	0.87
37_K	40_Y	0.775	0.87
75_H	169_G	0.772	0.87
58_L	61_A	0.771	0.87
16_Y	139_K	0.768	0.86
87_H	157_W	0.763	0.86
110_Y	114_L	0.762	0.86
91_I	96_L	0.759	0.86
68_Q	123_F	0.756	0.85
4_N	8_L	0.753	0.85
15_I	195_R	0.748	0.85
18_S	202_Y	0.742	0.84
164_E	167_E	0.741	0.84
23_P	26_L	0.738	0.84
140_V	161_Y	0.735	0.84
60_A	69_T	0.734	0.84
51_E	103_M	0.729	0.83
9_W	139_K	0.727	0.83
28_L	158_I	0.726	0.83
5_S	174_L	0.725	0.83
17_S	20_L	0.717	0.82
128_S	177_V	0.715	0.82
40_Y	207_S	0.713	0.82
187_F	191_K	0.709	0.82
78_D	82_V	0.708	0.82
165_E	168_K	0.708	0.82
171_R	174_L	0.706	0.81
20_L	139_K	0.704	0.81
206_D	209_Y	0.704	0.81
12_I	194_F	0.701	0.81
57_A	60_A	0.700	0.81
20_L	143_E	0.693	0.80
25_I	136_I	0.690	0.80
49_L	161_Y	0.690	0.80
45_D	83_E	0.688	0.80
22_H	206_D	0.680	0.79
16_Y	136_I	0.680	0.79
71_L	172_A	0.680	0.79
75_H	78_D	0.677	0.79
52_F	55_A	0.674	0.78
25_I	29_V	0.674	0.78
152_K	155_Q	0.671	0.78
17_S	143_E	0.667	0.78
132_P	194_F	0.666	0.77
200_Y	203_M	0.665	0.77
74_T	172_A	0.664	0.77
87_H	141_G	0.662	0.77
57_A	76_I	0.661	0.77
186_E	189_K	0.660	0.77
128_S	193_H	0.660	0.77
49_L	52_F	0.657	0.77
45_D	204_F	0.650	0.76
85_A	88_K	0.649	0.76
62_K	121_R	0.643	0.75
7_K	11_F	0.640	0.75
160_T	166_Y	0.640	0.75
109_A	112_S	0.639	0.75
65_D	179_S	0.638	0.74
36_D	168_K	0.637	0.74
113_Y	193_H	0.636	0.74
20_L	23_P	0.636	0.74
44_Q	107_N	0.635	0.74
15_I	202_Y	0.635	0.74
83_E	205_W	0.634	0.74
5_S	135_W	0.634	0.74
37_K	209_Y	0.633	0.74
57_A	63_A	0.630	0.73
89_F	92_K	0.627	0.73
148_G	151_D	0.625	0.73
141_G	160_T	0.624	0.73
18_S	21_R	0.623	0.73
138_M	171_R	0.622	0.73
189_K	193_H	0.622	0.73
52_F	169_G	0.622	0.73
110_Y	205_W	0.620	0.72
186_E	190_M	0.619	0.72
181_K	185_E	0.617	0.72
77_Q	80_I	0.617	0.72
55_A	126_V	0.615	0.72
52_F	197_A	0.611	0.71
27_E	32_I	0.610	0.71
132_P	161_Y	0.609	0.71
115_L	121_R	0.606	0.71
51_E	115_L	0.604	0.70
110_Y	133_C	0.604	0.70
97_D	101_Y	0.603	0.70
54_K	61_A	0.601	0.70
41_Y	141_G	0.599	0.70
129_A	133_C	0.598	0.70
141_G	161_Y	0.594	0.69
48_Y	134_Y	0.593	0.69
64_E	189_K	0.590	0.69
10_N	171_R	0.587	0.68
71_L	75_H	0.583	0.68
85_A	89_F	0.583	0.68
28_L	33_L	0.581	0.67
41_Y	52_F	0.579	0.67
90_Y	160_T	0.578	0.67
87_H	132_P	0.578	0.67
14_D	18_S	0.577	0.67
47_L	51_E	0.576	0.67
86_L	161_Y	0.576	0.67
62_K	126_V	0.575	0.67
90_Y	156_K	0.575	0.67
45_D	201_E	0.570	0.66
78_D	111_T	0.569	0.66
64_E	67_E	0.569	0.66
83_E	141_G	0.565	0.65
61_A	119_Y	0.564	0.65
110_Y	113_Y	0.563	0.65
39_K	100_D	0.563	0.65
49_L	87_H	0.562	0.65
44_Q	104_S	0.562	0.65
56_L	106_T	0.561	0.65
104_S	107_N	0.560	0.65
46_Y	88_K	0.560	0.65
16_Y	19_I	0.558	0.64
25_I	205_W	0.558	0.64
69_T	196_T	0.555	0.64
16_Y	20_L	0.555	0.64
157_W	161_Y	0.554	0.64
135_W	194_F	0.553	0.64
137_Y	204_F	0.551	0.63
202_Y	206_D	0.547	0.63
9_W	135_W	0.542	0.62
166_Y	174_L	0.541	0.62
15_I	199_I	0.540	0.62
131_L	174_L	0.539	0.62
15_I	18_S	0.536	0.61
147_Q	188_N	0.534	0.61
142_K	145_L	0.532	0.61
9_W	16_Y	0.529	0.60
111_T	114_L	0.528	0.60
54_K	58_L	0.528	0.60
102_E	192_I	0.525	0.60
137_Y	201_E	0.521	0.59
64_E	179_S	0.521	0.59
182_V	186_E	0.521	0.59
47_L	101_Y	0.520	0.59
33_L	38_F	0.515	0.58
52_F	83_E	0.510	0.57
114_L	136_I	0.509	0.57
114_L	132_P	0.507	0.57
19_I	134_Y	0.506	0.57
47_L	107_N	0.506	0.57
35_R	153_Y	0.505	0.57
106_T	207_S	0.505	0.57
83_E	137_Y	0.504	0.57
202_Y	209_Y	0.504	0.57
54_K	115_L	0.503	0.56
46_Y	50_R	0.501	0.56
141_G	205_W	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3no6A	4	0.9777	100	0.159	Contact Map
2qcxA	4	0.9777	100	0.169	Contact Map
2qzcA	4	0.9196	100	0.181	Contact Map
3rm5A	2	0.942	100	0.19	Contact Map
2a2mA	3	0.9152	100	0.191	Contact Map
1uddA	4	0.9286	100	0.193	Contact Map
3mvuA	4	0.9375	100	0.194	Contact Map
4fn6A	4	0.9643	100	0.199	Contact Map
2f2gA	1	0.9286	100	0.2	Contact Map
1rtwA	4	0.9241	100	0.205	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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