Q97VM3 - SULSO - GREMLIN Contacts

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Q97VM3 - L-isoaspartyl protein carboxyl methyltransferase (Pcm)

UniProt:	Q97VM3	Sequences: MSAKDDILRSIKNSKLANAFIKVNREDFLPQLLKKYAYDPNYVDKPFYITPNVTTTALSLGMYMLDILNLGETQKVLEIGTGIGYYTALMAEVVGDNNVISLEIDDTIFEYAKNILLPKYPRIKLIKTDGSLGYDKEAPYDRIIIWAAAPTVPCKLYDQLRENGIMVVPIGSEKAQGLYRITKIGYEPKIERLGDVIFMKMRGLFGFYEDDDPNERRIKKIEEKVNRLLSKFMSQS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	236 (197)
Sequences:	4275 (3034)
Seq/√Len:	216.2

ECOLI - PIMT
HALSA - Q9HST1
SULSO - Q97VM3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
81_T	101_S	2.654	1.00
22_K	92_E	2.650	1.00
109_F	127_K	2.626	1.00
103_E	109_F	2.555	1.00
165_I	180_R	2.510	1.00
165_I	182_T	2.493	1.00
154_C	158_D	2.468	1.00
101_S	125_L	2.457	1.00
157_Y	188_P	2.325	1.00
133_G	159_Q	2.271	1.00
111_Y	115_I	2.258	1.00
74_Q	142_R	2.256	1.00
162_E	185_G	2.155	1.00
12_K	66_D	2.151	1.00
67_I	193_L	2.088	1.00
109_F	125_L	2.068	1.00
145_I	168_V	2.038	1.00
134_Y	140_Y	2.016	1.00
18_N	22_K	2.006	1.00
98_N	124_K	1.972	1.00
68_L	142_R	1.965	1.00
126_I	134_Y	1.947	1.00
141_D	161_R	1.898	1.00
106_D	110_E	1.857	1.00
184_I	189_K	1.855	1.00
92_E	120_Y	1.839	1.00
27_D	118_P	1.825	1.00
177_G	192_R	1.806	1.00
106_D	127_K	1.806	1.00
65_L	89_L	1.787	1.00
183_K	188_P	1.783	1.00
145_I	156_L	1.772	1.00
116_L	125_L	1.767	1.00
51_P	105_D	1.725	1.00
143_I	160_L	1.692	1.00
51_P	107_T	1.690	1.00
17_A	21_I	1.677	1.00
182_T	191_E	1.669	1.00
137_E	140_Y	1.644	1.00
162_E	186_Y	1.636	1.00
184_I	187_E	1.628	1.00
142_R	165_I	1.617	1.00
180_R	191_E	1.550	1.00
116_L	123_I	1.471	1.00
179_Y	190_I	1.460	1.00
3_A	7_I	1.448	1.00
65_L	86_Y	1.441	1.00
104_I	202_R	1.440	1.00
70_L	90_M	1.413	1.00
20_F	62_M	1.407	1.00
6_D	17_A	1.402	1.00
75_K	98_N	1.398	1.00
13_N	66_D	1.398	1.00
162_E	184_I	1.394	1.00
60_L	196_V	1.389	1.00
139_P	159_Q	1.376	1.00
70_L	142_R	1.372	1.00
94_V	97_N	1.365	1.00
44_D	59_S	1.354	1.00
100_I	137_E	1.337	1.00
133_G	139_P	1.308	1.00
20_F	89_L	1.278	1.00
76_V	90_M	1.266	1.00
147_A	201_M	1.257	1.00
75_K	137_E	1.257	1.00
14_S	18_N	1.247	1.00
149_A	168_V	1.243	1.00
86_Y	144_I	1.235	1.00
64_M	198_F	1.235	1.00
29_L	47_F	1.230	1.00
138_A	159_Q	1.228	1.00
180_R	193_L	1.217	1.00
133_G	138_A	1.191	1.00
87_T	125_L	1.187	1.00
152_V	181_I	1.186	1.00
160_L	166_M	1.185	1.00
13_N	69_N	1.181	1.00
134_Y	137_E	1.176	1.00
110_E	113_K	1.175	1.00
78_E	146_W	1.173	1.00
178_L	196_V	1.169	1.00
70_L	94_V	1.161	1.00
160_L	164_G	1.157	1.00
124_K	137_E	1.154	1.00
86_Y	146_W	1.153	1.00
85_Y	89_L	1.145	1.00
39_D	45_K	1.132	1.00
55_T	61_G	1.131	1.00
15_K	72_E	1.130	1.00
179_Y	192_R	1.130	1.00
5_D	9_R	1.116	1.00
109_F	113_K	1.105	1.00
114_N	118_P	1.091	1.00
131_S	201_M	1.085	1.00
78_E	101_S	1.078	1.00
24_N	27_D	1.077	1.00
113_K	117_L	1.075	1.00
88_A	116_L	1.072	1.00
63_Y	194_G	1.069	1.00
15_K	93_V	1.063	1.00
100_I	134_Y	1.055	1.00
29_L	55_T	1.051	1.00
131_S	203_G	1.045	1.00
23_V	92_E	1.044	1.00
64_M	144_I	1.038	1.00
71_G	74_Q	1.032	1.00
181_I	188_P	1.027	1.00
87_T	91_A	1.022	1.00
7_I	21_I	1.018	1.00
120_Y	123_I	1.015	1.00
26_E	38_Y	1.007	1.00
162_E	183_K	0.999	1.00
100_I	126_I	0.999	1.00
19_A	92_E	0.986	1.00
94_V	122_R	0.972	1.00
91_A	122_R	0.968	1.00
157_Y	181_I	0.966	1.00
160_L	183_K	0.965	1.00
149_A	201_M	0.958	1.00
171_G	176_Q	0.953	1.00
87_T	123_I	0.952	1.00
6_D	11_I	0.948	1.00
34_K	37_A	0.933	0.99
61_G	86_Y	0.932	0.99
87_T	101_S	0.928	0.99
78_E	86_Y	0.918	0.99
53_V	199_M	0.915	0.99
64_M	86_Y	0.910	0.99
155_K	158_D	0.906	0.99
102_L	128_T	0.899	0.99
91_A	123_I	0.893	0.99
19_A	89_L	0.893	0.99
154_C	157_Y	0.880	0.99
67_I	167_V	0.877	0.99
78_E	81_T	0.876	0.99
19_A	93_V	0.875	0.99
56_T	60_L	0.873	0.99
167_V	180_R	0.872	0.99
169_P	198_F	0.866	0.99
11_I	17_A	0.850	0.99
18_N	21_I	0.850	0.99
30_P	111_Y	0.846	0.99
105_D	202_R	0.844	0.99
16_L	66_D	0.840	0.99
182_T	189_K	0.830	0.99
101_S	146_W	0.826	0.99
151_T	154_C	0.824	0.99
132_L	155_K	0.819	0.99
185_G	188_P	0.819	0.99
53_V	108_I	0.817	0.99
152_V	168_V	0.813	0.99
65_L	146_W	0.811	0.99
131_S	202_R	0.808	0.99
69_N	165_I	0.805	0.98
92_E	121_P	0.796	0.98
73_T	94_V	0.795	0.98
70_L	74_Q	0.793	0.98
100_I	124_K	0.786	0.98
33_L	47_F	0.775	0.98
136_K	139_P	0.775	0.98
115_I	118_P	0.774	0.98
70_L	76_V	0.772	0.98
16_L	93_V	0.770	0.98
4_K	8_L	0.767	0.98
181_I	190_I	0.764	0.98
56_T	169_P	0.763	0.98
112_A	115_I	0.761	0.98
170_I	179_Y	0.760	0.98
114_N	117_L	0.759	0.98
70_L	73_T	0.755	0.98
166_M	181_I	0.754	0.98
91_A	120_Y	0.752	0.98
69_N	180_R	0.752	0.98
11_I	62_M	0.749	0.98
74_Q	141_D	0.746	0.98
69_N	142_R	0.746	0.98
81_T	112_A	0.746	0.98
183_K	186_Y	0.745	0.97
15_K	71_G	0.744	0.97
119_K	122_R	0.743	0.97
46_P	56_T	0.743	0.97
76_V	99_V	0.743	0.97
152_V	170_I	0.738	0.97
11_I	66_D	0.724	0.97
77_L	140_Y	0.724	0.97
50_T	105_D	0.723	0.97
15_K	18_N	0.722	0.97
78_E	90_M	0.718	0.97
5_D	8_L	0.713	0.97
57_A	60_L	0.710	0.97
109_F	112_A	0.710	0.97
128_T	132_L	0.709	0.97
55_T	83_I	0.708	0.97
76_V	94_V	0.697	0.96
149_A	156_L	0.696	0.96
36_Y	39_D	0.691	0.96
156_L	166_M	0.691	0.96
101_S	116_L	0.689	0.96
145_I	201_M	0.680	0.96
75_K	100_I	0.678	0.96
81_T	146_W	0.678	0.96
9_R	59_S	0.675	0.96
145_I	149_A	0.673	0.95
162_E	188_P	0.668	0.95
15_K	19_A	0.666	0.95
20_F	58_L	0.662	0.95
131_S	149_A	0.662	0.95
65_L	90_M	0.661	0.95
79_I	130_G	0.654	0.95
177_G	195_D	0.650	0.95
162_E	187_E	0.648	0.94
129_D	132_L	0.646	0.94
46_P	49_I	0.646	0.94
100_I	140_Y	0.645	0.94
75_K	161_R	0.645	0.94
23_V	85_Y	0.643	0.94
56_T	198_F	0.642	0.94
53_V	104_I	0.641	0.94
175_A	195_D	0.631	0.94
13_N	70_L	0.630	0.94
135_D	139_P	0.629	0.94
5_D	11_I	0.628	0.93
20_F	85_Y	0.621	0.93
145_I	148_A	0.616	0.93
104_I	131_S	0.616	0.93
79_I	147_A	0.616	0.93
110_E	114_N	0.615	0.93
68_L	90_M	0.613	0.93
2_S	6_D	0.611	0.93
68_L	167_V	0.609	0.92
133_G	140_Y	0.608	0.92
2_S	21_I	0.599	0.92
14_S	17_A	0.598	0.92
24_N	38_Y	0.594	0.91
23_V	120_Y	0.592	0.91
44_D	57_A	0.591	0.91
5_D	10_S	0.589	0.91
54_T	199_M	0.588	0.91
53_V	105_D	0.586	0.91
61_G	146_W	0.577	0.90
126_I	136_K	0.577	0.90
91_A	121_P	0.577	0.90
130_G	139_P	0.575	0.90
87_T	99_V	0.572	0.90
171_G	196_V	0.571	0.90
56_T	146_W	0.571	0.90
7_I	14_S	0.569	0.90
3_A	21_I	0.569	0.90
83_I	108_I	0.569	0.90
73_T	97_N	0.568	0.90
193_L	196_V	0.563	0.89
150_P	203_G	0.562	0.89
28_F	88_A	0.562	0.89
168_V	179_Y	0.561	0.89
175_A	197_I	0.558	0.89
102_L	126_I	0.553	0.88
63_Y	178_L	0.553	0.88
6_D	10_S	0.553	0.88
56_T	61_G	0.551	0.88
27_D	119_K	0.546	0.88
61_G	144_I	0.543	0.87
98_N	137_E	0.543	0.87
130_G	159_Q	0.542	0.87
65_L	93_V	0.540	0.87
60_L	63_Y	0.540	0.87
64_M	167_V	0.538	0.87
79_I	201_M	0.537	0.87
126_I	137_E	0.534	0.87
46_P	57_A	0.533	0.86
170_I	181_I	0.530	0.86
163_N	182_T	0.530	0.86
147_A	198_F	0.528	0.86
38_Y	85_Y	0.527	0.86
31_Q	34_K	0.525	0.86
65_L	144_I	0.524	0.85
72_E	97_N	0.523	0.85
107_T	110_E	0.522	0.85
90_M	144_I	0.521	0.85
100_I	136_K	0.520	0.85
64_M	178_L	0.520	0.85
152_V	157_Y	0.519	0.85
113_K	125_L	0.519	0.85
56_T	64_M	0.518	0.85
148_A	176_Q	0.518	0.85
28_F	119_K	0.518	0.85
178_L	194_G	0.514	0.84
69_N	182_T	0.514	0.84
6_D	9_R	0.511	0.84
157_Y	190_I	0.510	0.84
49_I	54_T	0.508	0.84
87_T	90_M	0.503	0.83
63_Y	66_D	0.502	0.83
56_T	199_M	0.502	0.83
169_P	176_Q	0.501	0.83
157_Y	183_K	0.501	0.83
148_A	168_V	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jg1A	1	0.8602	100	0.499	Contact Map
4o29A	1	0.839	100	0.501	Contact Map
4l7vA	1	0.7627	100	0.512	Contact Map
1r18A	2	0.8178	100	0.55	Contact Map
2yxeA	2	0.8644	100	0.551	Contact Map
2pbfA	1	0.8263	100	0.552	Contact Map
1i1nA	1	0.8602	100	0.561	Contact Map
1vbfA	5	0.9492	100	0.569	Contact Map
3lbfA	1	0.8432	100	0.579	Contact Map
1dl5A	2	0.9703	100	0.596	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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