GREMLIN Database
Q97VM3 - L-isoaspartyl protein carboxyl methyltransferase (Pcm)
UniProt: Q97VM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 236 (197)
Sequences: 4275 (3034)
Seq/√Len: 216.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_T101_S2.6541.00
22_K92_E2.6501.00
109_F127_K2.6261.00
103_E109_F2.5551.00
165_I180_R2.5101.00
165_I182_T2.4931.00
154_C158_D2.4681.00
101_S125_L2.4571.00
157_Y188_P2.3251.00
133_G159_Q2.2711.00
111_Y115_I2.2581.00
74_Q142_R2.2561.00
162_E185_G2.1551.00
12_K66_D2.1511.00
67_I193_L2.0881.00
109_F125_L2.0681.00
145_I168_V2.0381.00
134_Y140_Y2.0161.00
18_N22_K2.0061.00
98_N124_K1.9721.00
68_L142_R1.9651.00
126_I134_Y1.9471.00
141_D161_R1.8981.00
106_D110_E1.8571.00
184_I189_K1.8551.00
92_E120_Y1.8391.00
27_D118_P1.8251.00
177_G192_R1.8061.00
106_D127_K1.8061.00
65_L89_L1.7871.00
183_K188_P1.7831.00
145_I156_L1.7721.00
116_L125_L1.7671.00
51_P105_D1.7251.00
143_I160_L1.6921.00
51_P107_T1.6901.00
17_A21_I1.6771.00
182_T191_E1.6691.00
137_E140_Y1.6441.00
162_E186_Y1.6361.00
184_I187_E1.6281.00
142_R165_I1.6171.00
180_R191_E1.5501.00
116_L123_I1.4711.00
179_Y190_I1.4601.00
3_A7_I1.4481.00
65_L86_Y1.4411.00
104_I202_R1.4401.00
70_L90_M1.4131.00
20_F62_M1.4071.00
6_D17_A1.4021.00
75_K98_N1.3981.00
13_N66_D1.3981.00
162_E184_I1.3941.00
60_L196_V1.3891.00
139_P159_Q1.3761.00
70_L142_R1.3721.00
94_V97_N1.3651.00
44_D59_S1.3541.00
100_I137_E1.3371.00
133_G139_P1.3081.00
20_F89_L1.2781.00
76_V90_M1.2661.00
147_A201_M1.2571.00
75_K137_E1.2571.00
14_S18_N1.2471.00
149_A168_V1.2431.00
86_Y144_I1.2351.00
64_M198_F1.2351.00
29_L47_F1.2301.00
138_A159_Q1.2281.00
180_R193_L1.2171.00
133_G138_A1.1911.00
87_T125_L1.1871.00
152_V181_I1.1861.00
160_L166_M1.1851.00
13_N69_N1.1811.00
134_Y137_E1.1761.00
110_E113_K1.1751.00
78_E146_W1.1731.00
178_L196_V1.1691.00
70_L94_V1.1611.00
160_L164_G1.1571.00
124_K137_E1.1541.00
86_Y146_W1.1531.00
85_Y89_L1.1451.00
39_D45_K1.1321.00
55_T61_G1.1311.00
15_K72_E1.1301.00
179_Y192_R1.1301.00
5_D9_R1.1161.00
109_F113_K1.1051.00
114_N118_P1.0911.00
131_S201_M1.0851.00
78_E101_S1.0781.00
24_N27_D1.0771.00
113_K117_L1.0751.00
88_A116_L1.0721.00
63_Y194_G1.0691.00
15_K93_V1.0631.00
100_I134_Y1.0551.00
29_L55_T1.0511.00
131_S203_G1.0451.00
23_V92_E1.0441.00
64_M144_I1.0381.00
71_G74_Q1.0321.00
181_I188_P1.0271.00
87_T91_A1.0221.00
7_I21_I1.0181.00
120_Y123_I1.0151.00
26_E38_Y1.0071.00
162_E183_K0.9991.00
100_I126_I0.9991.00
19_A92_E0.9861.00
94_V122_R0.9721.00
91_A122_R0.9681.00
157_Y181_I0.9661.00
160_L183_K0.9651.00
149_A201_M0.9581.00
171_G176_Q0.9531.00
87_T123_I0.9521.00
6_D11_I0.9481.00
34_K37_A0.9330.99
61_G86_Y0.9320.99
87_T101_S0.9280.99
78_E86_Y0.9180.99
53_V199_M0.9150.99
64_M86_Y0.9100.99
155_K158_D0.9060.99
102_L128_T0.8990.99
91_A123_I0.8930.99
19_A89_L0.8930.99
154_C157_Y0.8800.99
67_I167_V0.8770.99
78_E81_T0.8760.99
19_A93_V0.8750.99
56_T60_L0.8730.99
167_V180_R0.8720.99
169_P198_F0.8660.99
11_I17_A0.8500.99
18_N21_I0.8500.99
30_P111_Y0.8460.99
105_D202_R0.8440.99
16_L66_D0.8400.99
182_T189_K0.8300.99
101_S146_W0.8260.99
151_T154_C0.8240.99
132_L155_K0.8190.99
185_G188_P0.8190.99
53_V108_I0.8170.99
152_V168_V0.8130.99
65_L146_W0.8110.99
131_S202_R0.8080.99
69_N165_I0.8050.98
92_E121_P0.7960.98
73_T94_V0.7950.98
70_L74_Q0.7930.98
100_I124_K0.7860.98
33_L47_F0.7750.98
136_K139_P0.7750.98
115_I118_P0.7740.98
70_L76_V0.7720.98
16_L93_V0.7700.98
4_K8_L0.7670.98
181_I190_I0.7640.98
56_T169_P0.7630.98
112_A115_I0.7610.98
170_I179_Y0.7600.98
114_N117_L0.7590.98
70_L73_T0.7550.98
166_M181_I0.7540.98
91_A120_Y0.7520.98
69_N180_R0.7520.98
11_I62_M0.7490.98
74_Q141_D0.7460.98
69_N142_R0.7460.98
81_T112_A0.7460.98
183_K186_Y0.7450.97
15_K71_G0.7440.97
119_K122_R0.7430.97
46_P56_T0.7430.97
76_V99_V0.7430.97
152_V170_I0.7380.97
11_I66_D0.7240.97
77_L140_Y0.7240.97
50_T105_D0.7230.97
15_K18_N0.7220.97
78_E90_M0.7180.97
5_D8_L0.7130.97
57_A60_L0.7100.97
109_F112_A0.7100.97
128_T132_L0.7090.97
55_T83_I0.7080.97
76_V94_V0.6970.96
149_A156_L0.6960.96
36_Y39_D0.6910.96
156_L166_M0.6910.96
101_S116_L0.6890.96
145_I201_M0.6800.96
75_K100_I0.6780.96
81_T146_W0.6780.96
9_R59_S0.6750.96
145_I149_A0.6730.95
162_E188_P0.6680.95
15_K19_A0.6660.95
20_F58_L0.6620.95
131_S149_A0.6620.95
65_L90_M0.6610.95
79_I130_G0.6540.95
177_G195_D0.6500.95
162_E187_E0.6480.94
129_D132_L0.6460.94
46_P49_I0.6460.94
100_I140_Y0.6450.94
75_K161_R0.6450.94
23_V85_Y0.6430.94
56_T198_F0.6420.94
53_V104_I0.6410.94
175_A195_D0.6310.94
13_N70_L0.6300.94
135_D139_P0.6290.94
5_D11_I0.6280.93
20_F85_Y0.6210.93
145_I148_A0.6160.93
104_I131_S0.6160.93
79_I147_A0.6160.93
110_E114_N0.6150.93
68_L90_M0.6130.93
2_S6_D0.6110.93
68_L167_V0.6090.92
133_G140_Y0.6080.92
2_S21_I0.5990.92
14_S17_A0.5980.92
24_N38_Y0.5940.91
23_V120_Y0.5920.91
44_D57_A0.5910.91
5_D10_S0.5890.91
54_T199_M0.5880.91
53_V105_D0.5860.91
61_G146_W0.5770.90
126_I136_K0.5770.90
91_A121_P0.5770.90
130_G139_P0.5750.90
87_T99_V0.5720.90
171_G196_V0.5710.90
56_T146_W0.5710.90
7_I14_S0.5690.90
3_A21_I0.5690.90
83_I108_I0.5690.90
73_T97_N0.5680.90
193_L196_V0.5630.89
150_P203_G0.5620.89
28_F88_A0.5620.89
168_V179_Y0.5610.89
175_A197_I0.5580.89
102_L126_I0.5530.88
63_Y178_L0.5530.88
6_D10_S0.5530.88
56_T61_G0.5510.88
27_D119_K0.5460.88
61_G144_I0.5430.87
98_N137_E0.5430.87
130_G159_Q0.5420.87
65_L93_V0.5400.87
60_L63_Y0.5400.87
64_M167_V0.5380.87
79_I201_M0.5370.87
126_I137_E0.5340.87
46_P57_A0.5330.86
170_I181_I0.5300.86
163_N182_T0.5300.86
147_A198_F0.5280.86
38_Y85_Y0.5270.86
31_Q34_K0.5250.86
65_L144_I0.5240.85
72_E97_N0.5230.85
107_T110_E0.5220.85
90_M144_I0.5210.85
100_I136_K0.5200.85
64_M178_L0.5200.85
152_V157_Y0.5190.85
113_K125_L0.5190.85
56_T64_M0.5180.85
148_A176_Q0.5180.85
28_F119_K0.5180.85
178_L194_G0.5140.84
69_N182_T0.5140.84
6_D9_R0.5110.84
157_Y190_I0.5100.84
49_I54_T0.5080.84
87_T90_M0.5030.83
63_Y66_D0.5020.83
56_T199_M0.5020.83
169_P176_Q0.5010.83
157_Y183_K0.5010.83
148_A168_V0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jg1A 1 0.8602 100 0.499 Contact Map
4o29A 1 0.839 100 0.501 Contact Map
4l7vA 1 0.7627 100 0.512 Contact Map
1r18A 2 0.8178 100 0.55 Contact Map
2yxeA 2 0.8644 100 0.551 Contact Map
2pbfA 1 0.8263 100 0.552 Contact Map
1i1nA 1 0.8602 100 0.561 Contact Map
1vbfA 5 0.9492 100 0.569 Contact Map
3lbfA 1 0.8432 100 0.579 Contact Map
1dl5A 2 0.9703 100 0.596 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.