GREMLIN Database
Q97VL9 - Small heat shock protein hsp20 family
UniProt: Q97VL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (109)
Sequences: 5402 (4210)
Seq/√Len: 403.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
95_K98_S4.0141.00
36_E112_R3.0601.00
33_E36_E2.7071.00
41_A63_I2.6831.00
28_I88_I2.3061.00
47_N106_N2.2131.00
32_E115_V2.1901.00
28_I41_A2.1081.00
40_V110_T2.0531.00
66_E83_K2.0341.00
64_N85_H2.0011.00
42_D108_V1.9671.00
51_I104_Y1.9571.00
47_N50_K1.9471.00
33_E38_V1.9361.00
94_V113_I1.9091.00
60_E87_V1.6931.00
38_V110_T1.6741.00
43_L51_I1.6501.00
52_S64_N1.6311.00
29_D80_R1.5801.00
31_Y38_V1.5731.00
95_K116_E1.5711.00
60_E89_R1.5681.00
43_L104_Y1.5621.00
65_A84_I1.5311.00
29_D78_T1.5061.00
55_L90_L1.5041.00
98_S101_T1.5031.00
46_F65_A1.4951.00
42_D80_R1.4781.00
64_N83_K1.4611.00
62_I87_V1.4071.00
31_Y40_V1.3871.00
117_G120_S1.3551.00
39_V113_I1.3121.00
79_Q86_K1.2921.00
98_S114_P1.2651.00
26_P84_I1.2431.00
48_K52_S1.1801.00
29_D40_V1.1621.00
47_N105_E1.1521.00
50_K68_E1.1281.00
48_K106_N1.1111.00
12_K16_L1.1031.00
73_G76_Y1.0761.00
54_R62_I1.0621.00
50_K67_R1.0561.00
103_K110_T1.0531.00
35_G120_S1.0461.00
53_V111_I1.0311.00
59_N96_R1.0281.00
55_L100_V1.0261.00
61_L111_I1.0141.00
11_K14_D0.9961.00
69_I78_T0.9871.00
74_T77_A0.9681.00
37_L93_K0.9481.00
65_A82_L0.9461.00
53_V102_A0.9421.00
29_D42_D0.9361.00
90_L113_I0.9311.00
38_V112_R0.9221.00
26_P41_A0.9211.00
105_E110_T0.9071.00
43_L46_F0.9021.00
26_P43_L0.8951.00
42_D67_R0.8921.00
56_S60_E0.8891.00
96_R114_P0.8781.00
61_L100_V0.8761.00
103_K112_R0.8731.00
51_I80_R0.8581.00
93_K116_E0.8501.00
37_L92_V0.8491.00
39_V88_I0.8491.00
28_I63_I0.8491.00
18_R21_Y0.8351.00
55_L96_R0.8321.00
11_K15_E0.8261.00
46_F67_R0.8251.00
17_S20_F0.8241.00
101_T112_R0.8241.00
11_K16_L0.8201.00
93_K115_V0.8141.00
66_E81_P0.8091.00
24_V65_A0.8071.00
30_M39_V0.8051.00
30_M37_L0.8041.00
43_L65_A0.8031.00
46_F51_I0.7861.00
26_P65_A0.7841.00
40_V108_V0.7761.00
68_E81_P0.7751.00
32_E48_K0.7691.00
29_D81_P0.7631.00
43_L84_I0.7591.00
31_Y37_L0.7461.00
27_P42_D0.7401.00
91_P94_V0.7311.00
17_S21_Y0.7271.00
31_Y73_G0.7261.00
72_I78_T0.7191.00
67_R82_L0.7111.00
62_I85_H0.6991.00
12_K15_E0.6931.00
69_I81_P0.6911.00
102_A111_I0.6901.00
36_E115_V0.6770.99
46_F50_K0.6750.99
59_N92_V0.6750.99
47_N104_Y0.6710.99
15_E18_R0.6660.99
37_L100_V0.6550.99
54_R64_N0.6480.99
29_D43_L0.6370.99
41_A88_I0.6240.99
84_I100_V0.6200.99
72_I75_K0.6080.99
67_R81_P0.6020.99
52_S66_E0.6020.99
14_D17_S0.6010.99
16_L19_E0.5940.99
12_K18_R0.5850.98
116_E119_V0.5820.98
73_G77_A0.5810.98
51_I111_I0.5790.98
41_A53_V0.5750.98
55_L94_V0.5750.98
25_I29_D0.5720.98
48_K104_Y0.5670.98
87_V91_P0.5610.98
92_V116_E0.5600.98
56_S62_I0.5580.98
40_V45_G0.5580.98
13_L18_R0.5540.98
31_Y76_Y0.5530.98
71_Y75_K0.5510.98
27_P62_I0.5480.98
48_K115_V0.5480.98
65_A91_P0.5440.98
26_P79_Q0.5430.98
26_P91_P0.5390.97
55_L61_L0.5390.97
58_Q93_K0.5370.97
17_S22_E0.5360.97
42_D81_P0.5340.97
80_R100_V0.5290.97
79_Q88_I0.5280.97
35_G115_V0.5260.97
79_Q82_L0.5250.97
101_T110_T0.5220.97
46_F82_L0.5170.97
78_T81_P0.5170.97
100_V114_P0.5160.97
39_V67_R0.5160.97
70_Q81_P0.5110.96
13_L16_L0.5110.96
59_N89_R0.5080.96
24_V82_L0.5070.96
38_V41_A0.5030.96
80_R108_V0.5020.96
20_F23_S0.5010.96
46_F102_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eldA 4 0.8306 100 0.253 Contact Map
3aabA 2 0.9032 100 0.257 Contact Map
3w1zA 7 0.9839 100 0.279 Contact Map
2bolA 2 0.9516 99.9 0.322 Contact Map
1gmeA 6 0.9839 99.9 0.33 Contact Map
3glaA 2 0.7742 99.9 0.335 Contact Map
4jutA 4 0.7177 99.9 0.362 Contact Map
4ydzA 4 0.9113 99.9 0.363 Contact Map
4feiA 2 0.8065 99.9 0.368 Contact Map
4ye0A 2 0.7581 99.9 0.383 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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