GREMLIN Database
Q97VL8 - ABC transporter, ABC1 family, putative
UniProt: Q97VL8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 496 (389)
Sequences: 4909 (2980)
Seq/√Len: 151.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_E215_R4.4031.00
192_N211_K4.2751.00
120_L127_I4.0621.00
234_K238_N3.6521.00
116_G184_Y3.4641.00
197_E256_K3.4181.00
120_L221_Y3.1481.00
126_K210_I3.1411.00
269_A279_Y3.0721.00
122_E127_I3.0651.00
127_I223_K3.0651.00
193_K286_K3.0541.00
240_I244_R3.0371.00
222_I277_V3.0001.00
99_E213_T2.9591.00
97_D103_S2.9091.00
93_S97_D2.8131.00
87_A92_V2.8131.00
93_S105_K2.8101.00
41_A73_Y2.7461.00
271_D277_V2.7311.00
188_A211_K2.7261.00
126_K208_S2.7231.00
271_D275_N2.7041.00
71_E75_K2.5551.00
149_K175_S2.5491.00
191_L209_I2.5091.00
45_V76_E2.4701.00
110_L129_A2.4101.00
239_R390_D2.4071.00
129_A221_Y2.4011.00
142_N179_F2.3201.00
138_K214_K2.2951.00
229_S232_A2.2661.00
203_S244_R2.2561.00
130_I216_V2.2361.00
413_V416_Q2.2291.00
306_D309_S2.2201.00
133_N215_R2.2111.00
97_D104_V2.1501.00
251_Y256_K2.1371.00
88_P91_Q2.1071.00
205_R220_E2.0851.00
288_D291_T2.0671.00
42_K76_E2.0171.00
128_V218_V1.9751.00
102_N106_I1.9701.00
209_I219_M1.9681.00
133_N184_Y1.9311.00
210_I220_E1.9161.00
297_R309_S1.8981.00
301_A309_S1.8731.00
89_F93_S1.8721.00
195_K208_S1.8691.00
96_I100_L1.8531.00
89_F92_V1.8391.00
196_E199_S1.8301.00
96_I132_V1.8291.00
149_K172_E1.8081.00
188_A212_A1.7991.00
121_G130_I1.7981.00
205_R275_N1.7821.00
82_D226_K1.7741.00
251_Y255_N1.7671.00
92_V119_Y1.7601.00
188_A217_L1.7451.00
394_D397_K1.7351.00
212_A218_V1.7171.00
98_E215_R1.6781.00
100_L218_V1.6621.00
63_S81_Q1.6551.00
166_I169_V1.6481.00
185_T214_K1.6351.00
201_Y251_Y1.6351.00
96_I104_V1.6341.00
308_D330_A1.6251.00
188_A209_I1.6191.00
261_A283_M1.6051.00
66_P69_M1.5901.00
268_I278_L1.5871.00
123_Y128_V1.5861.00
159_F162_S1.5861.00
96_I106_I1.5751.00
183_D214_K1.5721.00
230_E234_K1.5711.00
130_I218_V1.5701.00
325_D328_V1.5671.00
87_A134_R1.5531.00
205_R271_D1.5491.00
413_V420_L1.5391.00
156_R168_K1.5311.00
94_K98_E1.5081.00
191_L219_M1.5081.00
138_K142_N1.5011.00
247_R398_S1.4841.00
76_E79_R1.4751.00
59_G80_L1.4601.00
195_K205_R1.4541.00
227_V270_V1.4491.00
248_L278_L1.4441.00
96_I216_V1.4441.00
259_F285_G1.4371.00
301_A310_L1.4361.00
110_L221_Y1.4341.00
223_K272_E1.4291.00
192_N195_K1.4241.00
156_R166_I1.4161.00
121_G128_V1.4151.00
107_L218_V1.3941.00
91_Q94_K1.3831.00
123_Y210_I1.3451.00
107_L121_G1.3391.00
257_D292_R1.3191.00
230_E238_N1.3191.00
193_K258_Y1.3061.00
45_V49_I1.2871.00
152_L168_K1.2841.00
175_S179_F1.2791.00
75_K78_A1.2721.00
294_L316_E1.2711.00
233_K236_V1.2661.00
112_S134_R1.2631.00
89_F104_V1.2591.00
300_V304_R1.2501.00
231_E235_I1.2491.00
180_E186_K1.2481.00
239_R392_D1.2451.00
44_F77_L1.2441.00
244_R276_L1.2431.00
133_N138_K1.2401.00
231_E234_K1.2331.00
189_F211_K1.2251.00
49_I79_R1.2211.00
203_S275_N1.2191.00
242_A389_I1.2111.00
145_I175_S1.2101.00
232_A235_I1.2021.00
400_I404_E1.1971.00
294_L313_V1.1971.00
245_V386_C1.1951.00
153_P168_K1.1941.00
222_I271_D1.1901.00
205_R277_V1.1851.00
205_R222_I1.1801.00
241_L270_V1.1731.00
48_L59_G1.1721.00
258_Y284_S1.1651.00
416_Q420_L1.1611.00
206_I284_S1.1591.00
93_S104_V1.1591.00
393_F398_S1.1571.00
141_V178_I1.1501.00
225_Y229_S1.1491.00
136_G140_T1.1431.00
413_V421_V1.1421.00
123_Y126_K1.1381.00
38_A75_K1.1381.00
253_L375_P1.1261.00
107_L130_I1.1251.00
81_Q226_K1.1170.99
92_V132_V1.1140.99
301_A313_V1.1130.99
346_S392_D1.1100.99
103_S106_I1.1080.99
106_I218_V1.0960.99
100_L107_L1.0960.99
208_S220_E1.0930.99
312_R326_R1.0880.99
248_L252_M1.0770.99
298_A310_L1.0750.99
233_K237_D1.0640.99
69_M74_I1.0570.99
291_T371_K1.0520.99
203_S247_R1.0500.99
46_D49_I1.0470.99
44_F73_Y1.0460.99
240_I243_Y1.0410.99
126_K220_E1.0400.99
194_I281_F1.0370.99
112_S115_L1.0310.99
87_A135_P1.0230.99
129_A219_M1.0200.99
332_G364_F1.0170.99
95_I99_E1.0130.99
34_E72_T1.0120.99
42_K45_V0.9930.99
190_Y284_S0.9880.99
152_L171_L0.9880.99
309_S312_R0.9880.99
198_L278_L0.9860.99
222_I269_A0.9850.99
52_G55_F0.9820.99
69_M77_L0.9800.99
229_S233_K0.9790.99
312_R316_E0.9790.99
236_V241_L0.9770.99
79_R83_E0.9740.99
414_I421_V0.9720.99
239_R243_Y0.9720.99
405_E409_T0.9700.99
170_F373_V0.9690.98
42_K79_R0.9640.98
138_K215_R0.9630.98
198_L252_M0.9610.98
118_V129_A0.9600.98
53_P383_D0.9580.98
62_L69_M0.9580.98
414_I418_R0.9540.98
81_Q265_P0.9520.98
38_A42_K0.9510.98
293_N297_R0.9430.98
297_R316_E0.9430.98
233_K238_N0.9420.98
242_A390_D0.9310.98
38_A76_E0.9300.98
82_D269_A0.9260.98
243_Y247_R0.9250.98
133_N214_K0.9240.98
197_E258_Y0.9170.98
37_M72_T0.9160.98
185_T212_A0.9160.98
181_E377_R0.9130.98
188_A192_N0.9100.98
255_N405_E0.9080.98
113_A181_E0.9070.98
245_V276_L0.8990.98
194_I198_L0.8970.98
40_E73_Y0.8960.98
120_L129_A0.8950.97
185_T189_F0.8930.97
278_L284_S0.8880.97
56_I84_V0.8840.97
261_A374_L0.8780.97
198_L248_L0.8770.97
193_K197_E0.8750.97
206_I281_F0.8640.97
39_E43_K0.8640.97
255_N402_F0.8620.97
100_L216_V0.8600.97
81_Q266_G0.8530.97
290_K316_E0.8530.97
129_A279_Y0.8510.97
344_E347_E0.8460.96
309_S313_V0.8440.96
186_K190_Y0.8440.96
325_D333_L0.8300.96
204_L278_L0.8290.96
281_F284_S0.8280.96
249_F382_L0.8280.96
191_L281_F0.8270.96
416_Q419_E0.8230.96
289_E292_R0.8210.96
242_A386_C0.8190.96
65_R383_D0.8190.96
414_I420_L0.8180.96
261_A285_G0.8130.96
110_L119_Y0.8120.96
45_V79_R0.8100.95
70_P73_Y0.8090.95
219_M279_Y0.8090.95
340_M356_L0.8080.95
204_L248_L0.8050.95
313_V317_L0.8030.95
238_N241_L0.8020.95
225_Y232_A0.8000.95
87_A95_I0.7980.95
248_L276_L0.7970.95
44_F48_L0.7930.95
234_K237_D0.7930.95
189_F192_N0.7880.95
192_N196_E0.7880.95
89_F119_Y0.7870.95
417_V421_V0.7850.95
57_K60_Q0.7810.95
290_K294_L0.7760.94
325_D332_G0.7750.94
416_Q421_V0.7740.94
32_I35_K0.7700.94
314_L333_L0.7690.94
42_K46_D0.7640.94
417_V420_L0.7620.94
148_V171_L0.7590.94
291_T317_L0.7590.94
225_Y236_V0.7580.94
190_Y258_Y0.7550.93
336_F360_V0.7540.93
121_G218_V0.7540.93
141_V182_M0.7500.93
333_L336_F0.7460.93
106_I216_V0.7460.93
360_V364_F0.7430.93
194_I284_S0.7420.93
289_E419_E0.7410.93
312_R315_D0.7410.93
194_I252_M0.7390.93
287_I375_P0.7360.93
91_Q95_I0.7350.93
197_E251_Y0.7330.92
136_G139_E0.7330.92
70_P74_I0.7330.92
225_Y272_E0.7310.92
137_I140_T0.7280.92
415_E418_R0.7270.92
123_Y218_V0.7260.92
308_D311_V0.7260.92
49_I52_G0.7220.92
225_Y233_K0.7210.92
349_E352_D0.7180.92
61_I174_F0.7160.92
168_K172_E0.7130.91
229_S236_V0.7130.91
94_K97_D0.7110.91
177_R180_E0.7090.91
169_V380_N0.7080.91
58_F174_F0.7060.91
100_L106_I0.7060.91
413_V417_V0.7050.91
188_A191_L0.7040.91
87_A91_Q0.7030.91
283_M377_R0.7020.91
183_D186_K0.7020.91
418_R421_V0.7010.91
89_F108_K0.7000.91
46_D76_E0.6960.90
174_F373_V0.6940.90
127_I221_Y0.6930.90
311_V315_D0.6930.90
247_R401_T0.6930.90
209_I212_A0.6930.90
83_E108_K0.6920.90
192_N208_S0.6920.90
55_F147_V0.6910.90
52_G134_R0.6890.90
415_E419_E0.6850.90
328_V332_G0.6850.90
308_D312_R0.6830.90
260_H264_H0.6820.89
404_E408_Y0.6820.89
238_N242_A0.6800.89
145_I179_F0.6780.89
415_E421_V0.6780.89
84_V112_S0.6780.89
114_S181_E0.6770.89
183_D189_F0.6770.89
377_R381_V0.6750.89
56_I85_P0.6750.89
225_Y237_D0.6730.89
395_F398_S0.6720.89
292_R402_F0.6720.89
195_K199_S0.6720.89
212_A217_L0.6700.89
96_I105_K0.6690.89
327_R330_A0.6680.88
46_D50_E0.6670.88
97_D102_N0.6650.88
38_A72_T0.6640.88
386_C395_F0.6610.88
115_L365_P0.6590.88
104_V107_L0.6580.88
49_I85_P0.6580.88
146_Q149_K0.6550.87
158_V161_E0.6540.87
63_S226_K0.6540.87
97_D105_K0.6530.87
87_A112_S0.6530.87
43_K141_V0.6510.87
307_A311_V0.6490.87
262_D267_N0.6490.87
149_K168_K0.6480.87
345_V349_E0.6480.87
41_A72_T0.6480.87
237_D240_I0.6450.87
189_F193_K0.6430.87
78_A81_Q0.6430.87
65_R134_R0.6380.86
100_L104_V0.6370.86
318_G366_L0.6370.86
53_P134_R0.6370.86
177_R374_L0.6370.86
269_A277_V0.6340.86
230_E388_E0.6310.86
250_M399_S0.6290.85
211_K218_V0.6290.85
100_L213_T0.6250.85
227_V276_L0.6250.85
253_L287_I0.6220.85
37_M73_Y0.6200.85
177_R283_M0.6200.85
230_E233_K0.6200.85
181_E263_P0.6190.84
397_K400_I0.6170.84
311_V320_I0.6160.84
294_L317_L0.6160.84
240_I274_G0.6150.84
413_V418_R0.6150.84
95_I215_R0.6120.84
198_L201_Y0.6120.84
77_L80_L0.6110.84
264_H267_N0.6110.84
56_I80_L0.6100.84
325_D331_K0.6100.84
278_L281_F0.6080.83
224_G277_V0.6080.83
98_E392_D0.6080.83
70_P379_V0.6080.83
156_R167_I0.6050.83
271_D274_G0.6050.83
310_L333_L0.6050.83
133_N369_P0.6050.83
166_I367_R0.6040.83
369_P377_R0.6040.83
95_I216_V0.6020.83
252_M381_V0.6010.83
191_L195_K0.6000.83
48_L77_L0.5990.82
246_F393_F0.5990.82
327_R331_K0.5990.82
292_R296_I0.5980.82
415_E420_L0.5970.82
300_V403_L0.5960.82
224_G269_A0.5960.82
173_E219_M0.5960.82
351_E354_M0.5960.82
186_K189_F0.5940.82
326_R333_L0.5930.82
92_V95_I0.5930.82
305_M338_Q0.5930.82
132_V216_V0.5910.82
66_P78_A0.5900.81
67_D383_D0.5890.81
110_L120_L0.5890.81
323_F326_R0.5880.81
65_R384_G0.5880.81
96_I107_L0.5870.81
329_L332_G0.5860.81
71_E74_I0.5840.81
142_N146_Q0.5840.81
47_T50_E0.5830.81
245_V268_I0.5830.81
98_E104_V0.5830.81
39_E42_K0.5820.81
106_I123_Y0.5810.81
102_N105_K0.5810.81
203_S240_I0.5790.80
252_M256_K0.5790.80
106_I130_I0.5790.80
304_R309_S0.5790.80
228_T388_E0.5790.80
33_D37_M0.5760.80
219_M281_F0.5750.80
147_V151_L0.5740.80
35_K108_K0.5740.80
113_A118_V0.5740.80
417_V422_N0.5720.79
85_P88_P0.5720.79
304_R400_I0.5710.79
409_T422_N0.5690.79
149_K153_P0.5690.79
315_D326_R0.5680.79
77_L109_E0.5680.79
121_G129_A0.5670.79
90_S93_S0.5670.79
90_S94_K0.5660.79
307_A330_A0.5660.79
243_Y398_S0.5640.79
195_K206_I0.5630.78
358_D361_F0.5630.78
44_F47_T0.5630.78
142_N175_S0.5620.78
185_T188_A0.5620.78
97_D132_V0.5610.78
81_Q228_T0.5610.78
124_N210_I0.5590.78
34_E37_M0.5590.78
298_A389_I0.5580.78
250_M254_L0.5580.78
307_A334_R0.5570.78
63_S144_D0.5570.78
193_K196_E0.5570.78
95_I98_E0.5560.78
181_E281_F0.5560.78
253_L378_M0.5550.77
252_M278_L0.5540.77
226_K229_S0.5530.77
99_E214_K0.5510.77
55_F383_D0.5500.77
113_A377_R0.5490.77
412_V420_L0.5490.77
86_P134_R0.5490.77
387_R394_D0.5480.77
242_A391_K0.5470.76
53_P296_I0.5470.76
64_V384_G0.5470.76
91_Q136_G0.5460.76
191_L211_K0.5450.76
36_E40_E0.5440.76
339_A356_L0.5440.76
348_L351_E0.5430.76
300_V394_D0.5420.76
410_T413_V0.5400.76
113_A184_Y0.5390.75
375_P378_M0.5380.75
106_I213_T0.5380.75
311_V330_A0.5380.75
374_L377_R0.5350.75
408_Y411_K0.5350.75
138_K146_Q0.5340.75
41_A318_G0.5330.75
40_E72_T0.5330.75
305_M341_Q0.5330.75
221_Y269_A0.5330.75
51_L54_T0.5330.75
116_G387_R0.5320.74
72_T76_E0.5310.74
74_I78_A0.5310.74
154_L158_V0.5310.74
96_I103_S0.5300.74
244_R275_N0.5290.74
98_E139_E0.5280.74
47_T51_L0.5280.74
249_F394_D0.5280.74
185_T192_N0.5270.74
52_G65_R0.5270.74
101_G104_V0.5270.74
48_L254_L0.5260.74
182_M287_I0.5250.73
129_A150_K0.5250.73
245_V382_L0.5250.73
184_Y281_F0.5250.73
52_G260_H0.5250.73
419_E422_N0.5250.73
288_D371_K0.5250.73
184_Y283_M0.5250.73
113_A117_Q0.5240.73
131_K187_E0.5240.73
84_V134_R0.5230.73
44_F62_L0.5230.73
198_L206_I0.5230.73
333_L337_M0.5220.73
250_M299_Y0.5220.73
296_I407_G0.5210.73
115_L133_N0.5210.73
57_K264_H0.5200.73
270_V278_L0.5190.73
64_V381_V0.5190.73
42_K322_P0.5190.73
111_S394_D0.5180.72
151_L155_L0.5180.72
134_R137_I0.5180.72
329_L366_L0.5180.72
252_M260_H0.5170.72
87_A119_Y0.5150.72
198_L245_V0.5150.72
385_T388_E0.5140.72
243_Y393_F0.5140.72
350_L371_K0.5130.72
53_P377_R0.5130.72
250_M379_V0.5130.72
406_E409_T0.5130.72
52_G285_G0.5120.72
325_D329_L0.5120.72
243_Y390_D0.5120.72
262_D266_G0.5100.71
418_R422_N0.5090.71
172_E175_S0.5080.71
59_G77_L0.5070.71
311_V333_L0.5060.71
291_T372_L0.5050.71
291_T294_L0.5050.71
414_I417_V0.5040.70
247_R251_Y0.5040.70
139_E202_P0.5040.70
49_I84_V0.5040.70
94_K102_N0.5030.70
113_A281_F0.5030.70
293_N410_T0.5030.70
57_K267_N0.5030.70
57_K282_G0.5020.70
287_I371_K0.5020.70
313_V316_E0.5020.70
183_D310_L0.5010.70
64_V81_Q0.5010.70
57_K131_K0.5000.70
174_F386_C0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pedA 1 0.7419 100 0.428 Contact Map
3byvA 1 0.6472 100 0.721 Contact Map
2y7jA 3 0.4778 100 0.727 Contact Map
4yhjA 2 0.8145 100 0.743 Contact Map
3v5wA 1 0.8125 100 0.797 Contact Map
1zarA 1 0.498 99.9 0.813 Contact Map
1u5qA 2 0.5887 99.9 0.817 Contact Map
4otpA 1 0.4597 99.9 0.827 Contact Map
3dzoA 1 0.623 99.8 0.842 Contact Map
3fegA 2 0.6109 99.8 0.852 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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