GREMLIN Database
Q97VL1 - HtrA like serine protease (Periplasmic)
UniProt: Q97VL1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (284)
Sequences: 8830 (5958)
Seq/√Len: 353.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_N162_E5.1201.00
7_E101_K4.5061.00
251_K278_K4.2871.00
279_M288_L3.8771.00
50_Y76_I3.1981.00
95_K162_E3.0081.00
274_Q289_S2.9061.00
278_K285_E2.8691.00
276_N287_E2.8551.00
98_K184_K2.7231.00
94_L163_V2.5891.00
72_Q88_T2.4821.00
71_A85_L2.3561.00
276_N289_S2.3411.00
59_I73_V2.3321.00
12_S93_S2.2601.00
39_Y166_T2.2141.00
279_M286_I2.2031.00
84_M194_M2.1731.00
60_L68_R2.1111.00
58_E70_E2.0221.00
250_L280_L1.9951.00
251_K256_E1.9751.00
19_K58_E1.9501.00
6_V118_V1.9411.00
147_V178_G1.9411.00
258_K262_D1.9401.00
82_L166_T1.9371.00
270_M273_S1.9181.00
274_Q291_P1.9081.00
207_G231_N1.8991.00
278_K287_E1.8951.00
105_V120_M1.8941.00
251_K254_N1.8841.00
96_L187_D1.8811.00
204_V290_I1.8771.00
196_F200_I1.8531.00
39_Y163_V1.8281.00
69_E87_S1.8271.00
39_Y94_L1.8221.00
39_Y155_P1.8111.00
3_E104_E1.8091.00
123_I141_V1.8091.00
247_D281_R1.8011.00
96_L183_S1.7921.00
208_V260_P1.7591.00
191_K195_K1.7431.00
243_I277_V1.7201.00
235_N239_Y1.7041.00
192_N196_F1.6971.00
63_S69_E1.6821.00
40_S91_L1.6611.00
203_Y237_S1.6531.00
243_I279_M1.6391.00
47_I186_V1.6391.00
60_L70_E1.6181.00
210_K260_P1.6121.00
240_K293_P1.5851.00
94_L157_I1.5831.00
250_L285_E1.5621.00
9_V157_I1.5601.00
72_Q86_R1.5601.00
47_I190_V1.5491.00
3_E101_K1.5231.00
255_Q266_V1.5101.00
259_S262_D1.5001.00
38_G46_L1.4991.00
42_G45_I1.4851.00
9_V94_L1.4661.00
43_K90_E1.4611.00
281_R286_I1.4571.00
187_D191_K1.4331.00
225_N256_E1.4271.00
250_L278_K1.4251.00
45_I86_R1.4201.00
45_I74_I1.4151.00
155_P163_V1.4041.00
166_T186_V1.3981.00
18_T59_I1.3901.00
97_A184_K1.3751.00
45_I194_M1.3741.00
17_I62_I1.3701.00
105_V159_T1.3701.00
12_S94_L1.3241.00
234_P239_Y1.3211.00
41_I190_V1.3191.00
5_L157_I1.3111.00
280_L285_E1.3081.00
40_S63_S1.2811.00
253_N276_N1.2731.00
75_A193_V1.2701.00
127_E139_Y1.2691.00
51_H81_D1.2511.00
237_S293_P1.2391.00
77_N80_H1.2341.00
46_L87_S1.2261.00
202_P271_V1.2141.00
212_N215_L1.2041.00
113_L171_I1.2021.00
100_C164_V1.2011.00
102_T126_E1.1991.00
243_I288_L1.1931.00
37_S155_P1.1881.00
50_Y54_S1.1811.00
170_M174_A1.1791.00
225_N258_K1.1761.00
51_H152_S1.1681.00
62_I68_R1.1601.00
14_V46_L1.1571.00
231_N245_R1.1561.00
100_C123_I1.1551.00
203_Y233_D1.1501.00
252_V277_V1.1471.00
20_Q32_A1.1421.00
229_V243_I1.1311.00
108_A156_L1.1301.00
126_E141_V1.1281.00
16_I85_L1.1261.00
191_K194_M1.1191.00
233_D236_G1.1191.00
156_L167_V1.1151.00
56_A59_I1.0981.00
8_R95_K1.0931.00
275_I292_V1.0931.00
107_L159_T1.0811.00
5_L107_L1.0801.00
170_M175_Q1.0791.00
253_N266_V1.0751.00
45_I84_M1.0751.00
143_T156_L1.0701.00
280_L283_S1.0651.00
252_V263_L1.0631.00
36_G52_V1.0611.00
4_D101_K1.0591.00
209_I230_T1.0511.00
73_V76_I1.0501.00
16_I61_V1.0371.00
42_G194_M1.0291.00
106_V123_I1.0271.00
228_L246_G1.0221.00
232_I236_G1.0151.00
108_A167_V1.0091.00
100_C141_V1.0091.00
113_L174_A1.0081.00
74_I86_R1.0031.00
5_L9_V1.0031.00
244_R281_R0.9981.00
6_V107_L0.9881.00
19_K31_V0.9701.00
9_V109_V0.9671.00
147_V167_V0.9661.00
190_V194_M0.9651.00
80_H189_F0.9611.00
208_V227_L0.9551.00
6_V10_T0.9551.00
188_S192_N0.9511.00
54_S78_P0.9471.00
210_K259_S0.9411.00
14_V38_G0.9401.00
202_P292_V0.9351.00
61_V87_S0.9261.00
11_P92_P0.9231.00
207_G233_D0.9221.00
257_V266_V0.9221.00
43_K93_S0.9221.00
63_S67_F0.9181.00
80_H201_R0.9161.00
101_K104_E0.9111.00
252_V275_I0.9071.00
226_G248_I0.9021.00
50_Y78_P0.9011.00
19_K33_E0.8961.00
118_V122_I0.8961.00
4_D8_R0.8931.00
111_N116_Y0.8901.00
254_N276_N0.8871.00
12_S92_P0.8861.00
77_N201_R0.8861.00
44_N86_R0.8761.00
106_V159_T0.8751.00
205_G237_S0.8731.00
10_T64_E0.8731.00
81_D152_S0.8641.00
5_L8_R0.8631.00
41_I84_M0.8631.00
61_V71_A0.8481.00
42_G93_S0.8391.00
204_V277_V0.8361.00
232_I245_R0.8341.00
229_V249_I0.8321.00
207_G230_T0.8291.00
128_R142_Q0.8281.00
100_C126_E0.8261.00
75_A84_M0.8231.00
142_Q179_F0.8221.00
186_V190_V0.8221.00
227_L257_V0.8221.00
19_K60_L0.8211.00
41_I47_I0.8191.00
84_M193_V0.8161.00
113_L175_Q0.8151.00
277_V290_I0.8141.00
208_V263_L0.8091.00
244_R282_D0.8041.00
63_S87_S0.8041.00
252_V267_L0.8041.00
189_F193_V0.8011.00
18_T35_I0.7981.00
130_I140_V0.7981.00
41_I194_M0.7961.00
253_N275_I0.7941.00
51_H150_G0.7911.00
15_T34_G0.7901.00
156_L180_A0.7881.00
96_L163_V0.7871.00
192_N197_G0.7861.00
271_V293_P0.7791.00
251_K285_E0.7791.00
233_D239_Y0.7791.00
241_Y290_I0.7781.00
49_S181_I0.7781.00
145_A178_G0.7751.00
46_L85_L0.7721.00
106_V164_V0.7671.00
262_D266_V0.7601.00
8_R92_P0.7551.00
277_V288_L0.7551.00
206_I227_L0.7531.00
120_M144_D0.7531.00
232_I239_Y0.7461.00
274_Q292_V0.7451.00
15_T111_N0.7401.00
163_V183_S0.7391.00
249_I257_V0.7391.00
82_L190_V0.7381.00
40_S46_L0.7361.00
266_V269_E0.7331.00
183_S187_D0.7291.00
100_C106_V0.7291.00
213_K217_T0.7291.00
40_S87_S0.7260.99
17_I68_R0.7250.99
238_A241_Y0.7230.99
139_Y185_L0.7190.99
49_S167_V0.7170.99
107_L118_V0.7130.99
135_G138_I0.7100.99
222_R280_L0.7100.99
49_S81_D0.7090.99
111_N114_G0.7070.99
281_R284_K0.7040.99
84_M190_V0.7010.99
192_N199_Y0.6980.99
13_V155_P0.6960.99
167_V180_A0.6920.99
244_R247_D0.6910.99
192_N195_K0.6880.99
254_N278_K0.6880.99
273_S292_V0.6860.99
235_N240_K0.6830.99
209_I228_L0.6820.99
53_I76_I0.6810.99
59_I85_L0.6810.99
15_T116_Y0.6790.99
18_T56_A0.6780.99
70_E88_T0.6770.99
252_V266_V0.6740.99
211_L224_Q0.6740.99
171_I174_A0.6730.99
136_L264_L0.6720.99
232_I242_G0.6710.99
211_L248_I0.6690.99
99_E184_K0.6680.99
80_H185_L0.6660.99
202_P273_S0.6650.99
52_V152_S0.6650.99
39_Y47_I0.6650.99
46_L61_V0.6640.99
49_S52_V0.6630.99
284_K289_S0.6590.99
128_R179_F0.6580.99
17_I60_L0.6570.99
286_I289_S0.6560.99
209_I215_L0.6560.99
216_A221_V0.6540.99
231_N234_P0.6520.99
183_S186_V0.6510.99
281_R288_L0.6510.99
54_S76_I0.6500.99
208_V264_L0.6500.99
18_T57_E0.6490.99
193_V199_Y0.6450.99
210_K261_I0.6450.99
149_P173_E0.6450.99
206_I243_I0.6450.99
203_Y208_V0.6440.99
129_A140_V0.6430.99
146_A174_A0.6420.99
204_V292_V0.6390.99
42_G86_R0.6360.99
184_K187_D0.6350.99
165_G180_A0.6320.99
106_V120_M0.6310.99
196_F199_Y0.6300.99
210_K227_L0.6260.98
15_T35_I0.6250.98
279_M287_E0.6250.98
236_G239_Y0.6240.98
67_F89_I0.6230.98
253_N273_S0.6180.98
3_E6_V0.6180.98
43_K92_P0.6180.98
17_I35_I0.6180.98
158_N164_V0.6180.98
107_L120_M0.6160.98
109_V157_I0.6150.98
215_L218_Y0.6150.98
212_N216_A0.6150.98
69_E91_L0.6140.98
67_F90_E0.6130.98
148_N151_N0.6110.98
63_S91_L0.6090.98
138_I168_T0.6090.98
18_T34_G0.6090.98
40_S93_S0.6080.98
75_A189_F0.6070.98
155_P167_V0.6060.98
237_S241_Y0.6060.98
264_L267_L0.6040.98
47_I82_L0.6020.98
211_L221_V0.6020.98
113_L170_M0.6000.98
260_P264_L0.5960.98
35_I115_L0.5950.98
262_D265_A0.5940.98
134_N138_I0.5940.98
48_T83_A0.5930.98
131_M135_G0.5900.98
255_Q269_E0.5870.98
143_T180_A0.5840.98
257_V263_L0.5840.98
53_I59_I0.5830.98
11_P64_E0.5820.98
124_S142_Q0.5810.98
264_L268_E0.5800.98
41_I96_L0.5770.97
275_I290_I0.5770.97
151_N154_G0.5770.97
169_A172_R0.5730.97
20_Q57_E0.5720.97
215_L219_L0.5710.97
200_I292_V0.5710.97
265_A269_E0.5680.97
130_I136_L0.5650.97
140_V168_T0.5650.97
80_H138_I0.5640.97
251_K287_E0.5610.97
97_A100_C0.5600.97
125_S128_R0.5600.97
257_V277_V0.5590.97
204_V263_L0.5590.97
211_L216_A0.5560.97
244_R286_I0.5550.97
263_L277_V0.5540.97
49_S152_S0.5540.97
4_D7_E0.5530.97
43_K89_I0.5510.97
80_H199_Y0.5500.97
20_Q55_N0.5500.97
188_S269_E0.5480.97
20_Q33_E0.5460.96
37_S112_P0.5450.96
272_G291_P0.5450.96
238_A242_G0.5440.96
81_D150_G0.5440.96
20_Q34_G0.5420.96
49_S151_N0.5420.96
99_E160_R0.5400.96
239_Y244_R0.5370.96
100_C184_K0.5370.96
229_V288_L0.5370.96
106_V156_L0.5360.96
148_N176_N0.5360.96
53_I83_A0.5360.96
96_L186_V0.5360.96
16_I38_G0.5330.96
41_I45_I0.5330.96
53_I56_A0.5320.96
17_I33_E0.5300.96
142_Q148_N0.5290.96
102_T118_V0.5280.96
124_S128_R0.5270.96
109_V118_V0.5240.96
232_I238_A0.5230.95
8_R11_P0.5220.95
239_Y242_G0.5220.95
37_S111_N0.5220.95
188_S270_M0.5210.95
252_V257_V0.5210.95
130_I169_A0.5210.95
100_C183_S0.5210.95
227_L260_P0.5200.95
82_L186_V0.5190.95
115_L130_I0.5190.95
221_V248_I0.5190.95
113_L177_I0.5170.95
185_L189_F0.5150.95
243_I247_D0.5150.95
6_V109_V0.5140.95
90_E93_S0.5110.95
232_I241_Y0.5110.95
111_N179_F0.5090.95
62_I66_G0.5080.95
189_F199_Y0.5080.95
187_D190_V0.5080.95
216_A219_L0.5070.95
141_V156_L0.5060.95
94_L183_S0.5050.95
104_E158_N0.5040.94
10_T102_T0.5040.94
205_G236_G0.5040.94
131_M136_L0.5030.94
172_R175_Q0.5020.94
36_G51_H0.5020.94
188_S191_K0.5000.94
252_V292_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.9764 100 0.253 Contact Map
3pv2A 6 0.9461 100 0.256 Contact Map
3stjA 6 0.963 100 0.258 Contact Map
4a8cA 5 0.9731 100 0.266 Contact Map
1lcyA 3 0.9226 100 0.306 Contact Map
4flnA 5 0.9764 100 0.306 Contact Map
1te0A 6 0.9933 100 0.311 Contact Map
4ri0A 3 0.9495 100 0.315 Contact Map
3qo6A 5 0.9832 100 0.323 Contact Map
3numA 3 0.5892 100 0.324 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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