Q97VL1 - SULSO - GREMLIN Contacts

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Q97VL1 - HtrA like serine protease (Periplasmic)

UniProt:	Q97VL1	Sequences: MYEDLVERVTPSVVTIITKQIALDQFFMPQVAEGIGSGYSIGKNILITSYHVISNAEEILVISEDGFREEAQVIAINPFHDLAMLRSTIELPSLKLAKECKTGEVVLAVGNPLGLYSVSMGIISSEERAIMTPNGLPIYVVQTDAAVNPGNSGGPLINTRGEVVGTVTAMIREAQNIGFAIPSKLVDSFVKNVMKFGRYIRPYVGIGVIKLNKALATYLGVRKQNGLLVTNIDPNGSAYKYGIRRGDIILKVNNQEVKSPIDLLAVLEEMVGSQINVKMLRDSKEIELSIPVPGLST	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	297 (284)
Sequences:	8830 (5958)
Seq/√Len:	353.6

ECOLI - DEGP DEGQ DEGS
BACSU - HTRB YYXA HTRA
HALSA - Q9HSH6
SULSO - Q97VL1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_N	162_E	5.120	1.00
7_E	101_K	4.506	1.00
251_K	278_K	4.287	1.00
279_M	288_L	3.877	1.00
50_Y	76_I	3.198	1.00
95_K	162_E	3.008	1.00
274_Q	289_S	2.906	1.00
278_K	285_E	2.869	1.00
276_N	287_E	2.855	1.00
98_K	184_K	2.723	1.00
94_L	163_V	2.589	1.00
72_Q	88_T	2.482	1.00
71_A	85_L	2.356	1.00
276_N	289_S	2.341	1.00
59_I	73_V	2.332	1.00
12_S	93_S	2.260	1.00
39_Y	166_T	2.214	1.00
279_M	286_I	2.203	1.00
84_M	194_M	2.173	1.00
60_L	68_R	2.111	1.00
58_E	70_E	2.022	1.00
250_L	280_L	1.995	1.00
251_K	256_E	1.975	1.00
19_K	58_E	1.950	1.00
6_V	118_V	1.941	1.00
147_V	178_G	1.941	1.00
258_K	262_D	1.940	1.00
82_L	166_T	1.937	1.00
270_M	273_S	1.918	1.00
274_Q	291_P	1.908	1.00
207_G	231_N	1.899	1.00
278_K	287_E	1.895	1.00
105_V	120_M	1.894	1.00
251_K	254_N	1.884	1.00
96_L	187_D	1.881	1.00
204_V	290_I	1.877	1.00
196_F	200_I	1.853	1.00
39_Y	163_V	1.828	1.00
69_E	87_S	1.827	1.00
39_Y	94_L	1.822	1.00
39_Y	155_P	1.811	1.00
3_E	104_E	1.809	1.00
123_I	141_V	1.809	1.00
247_D	281_R	1.801	1.00
96_L	183_S	1.792	1.00
208_V	260_P	1.759	1.00
191_K	195_K	1.743	1.00
243_I	277_V	1.720	1.00
235_N	239_Y	1.704	1.00
192_N	196_F	1.697	1.00
63_S	69_E	1.682	1.00
40_S	91_L	1.661	1.00
203_Y	237_S	1.653	1.00
243_I	279_M	1.639	1.00
47_I	186_V	1.639	1.00
60_L	70_E	1.618	1.00
210_K	260_P	1.612	1.00
240_K	293_P	1.585	1.00
94_L	157_I	1.583	1.00
250_L	285_E	1.562	1.00
9_V	157_I	1.560	1.00
72_Q	86_R	1.560	1.00
47_I	190_V	1.549	1.00
3_E	101_K	1.523	1.00
255_Q	266_V	1.510	1.00
259_S	262_D	1.500	1.00
38_G	46_L	1.499	1.00
42_G	45_I	1.485	1.00
9_V	94_L	1.466	1.00
43_K	90_E	1.461	1.00
281_R	286_I	1.457	1.00
187_D	191_K	1.433	1.00
225_N	256_E	1.427	1.00
250_L	278_K	1.425	1.00
45_I	86_R	1.420	1.00
45_I	74_I	1.415	1.00
155_P	163_V	1.404	1.00
166_T	186_V	1.398	1.00
18_T	59_I	1.390	1.00
97_A	184_K	1.375	1.00
45_I	194_M	1.374	1.00
17_I	62_I	1.370	1.00
105_V	159_T	1.370	1.00
12_S	94_L	1.324	1.00
234_P	239_Y	1.321	1.00
41_I	190_V	1.319	1.00
5_L	157_I	1.311	1.00
280_L	285_E	1.308	1.00
40_S	63_S	1.281	1.00
253_N	276_N	1.273	1.00
75_A	193_V	1.270	1.00
127_E	139_Y	1.269	1.00
51_H	81_D	1.251	1.00
237_S	293_P	1.239	1.00
77_N	80_H	1.234	1.00
46_L	87_S	1.226	1.00
202_P	271_V	1.214	1.00
212_N	215_L	1.204	1.00
113_L	171_I	1.202	1.00
100_C	164_V	1.201	1.00
102_T	126_E	1.199	1.00
243_I	288_L	1.193	1.00
37_S	155_P	1.188	1.00
50_Y	54_S	1.181	1.00
170_M	174_A	1.179	1.00
225_N	258_K	1.176	1.00
51_H	152_S	1.168	1.00
62_I	68_R	1.160	1.00
14_V	46_L	1.157	1.00
231_N	245_R	1.156	1.00
100_C	123_I	1.155	1.00
203_Y	233_D	1.150	1.00
252_V	277_V	1.147	1.00
20_Q	32_A	1.142	1.00
229_V	243_I	1.131	1.00
108_A	156_L	1.130	1.00
126_E	141_V	1.128	1.00
16_I	85_L	1.126	1.00
191_K	194_M	1.119	1.00
233_D	236_G	1.119	1.00
156_L	167_V	1.115	1.00
56_A	59_I	1.098	1.00
8_R	95_K	1.093	1.00
275_I	292_V	1.093	1.00
107_L	159_T	1.081	1.00
5_L	107_L	1.080	1.00
170_M	175_Q	1.079	1.00
253_N	266_V	1.075	1.00
45_I	84_M	1.075	1.00
143_T	156_L	1.070	1.00
280_L	283_S	1.065	1.00
252_V	263_L	1.063	1.00
36_G	52_V	1.061	1.00
4_D	101_K	1.059	1.00
209_I	230_T	1.051	1.00
73_V	76_I	1.050	1.00
16_I	61_V	1.037	1.00
42_G	194_M	1.029	1.00
106_V	123_I	1.027	1.00
228_L	246_G	1.022	1.00
232_I	236_G	1.015	1.00
108_A	167_V	1.009	1.00
100_C	141_V	1.009	1.00
113_L	174_A	1.008	1.00
74_I	86_R	1.003	1.00
5_L	9_V	1.003	1.00
244_R	281_R	0.998	1.00
6_V	107_L	0.988	1.00
19_K	31_V	0.970	1.00
9_V	109_V	0.967	1.00
147_V	167_V	0.966	1.00
190_V	194_M	0.965	1.00
80_H	189_F	0.961	1.00
208_V	227_L	0.955	1.00
6_V	10_T	0.955	1.00
188_S	192_N	0.951	1.00
54_S	78_P	0.947	1.00
210_K	259_S	0.941	1.00
14_V	38_G	0.940	1.00
202_P	292_V	0.935	1.00
61_V	87_S	0.926	1.00
11_P	92_P	0.923	1.00
207_G	233_D	0.922	1.00
257_V	266_V	0.922	1.00
43_K	93_S	0.922	1.00
63_S	67_F	0.918	1.00
80_H	201_R	0.916	1.00
101_K	104_E	0.911	1.00
252_V	275_I	0.907	1.00
226_G	248_I	0.902	1.00
50_Y	78_P	0.901	1.00
19_K	33_E	0.896	1.00
118_V	122_I	0.896	1.00
4_D	8_R	0.893	1.00
111_N	116_Y	0.890	1.00
254_N	276_N	0.887	1.00
12_S	92_P	0.886	1.00
77_N	201_R	0.886	1.00
44_N	86_R	0.876	1.00
106_V	159_T	0.875	1.00
205_G	237_S	0.873	1.00
10_T	64_E	0.873	1.00
81_D	152_S	0.864	1.00
5_L	8_R	0.863	1.00
41_I	84_M	0.863	1.00
61_V	71_A	0.848	1.00
42_G	93_S	0.839	1.00
204_V	277_V	0.836	1.00
232_I	245_R	0.834	1.00
229_V	249_I	0.832	1.00
207_G	230_T	0.829	1.00
128_R	142_Q	0.828	1.00
100_C	126_E	0.826	1.00
75_A	84_M	0.823	1.00
142_Q	179_F	0.822	1.00
186_V	190_V	0.822	1.00
227_L	257_V	0.822	1.00
19_K	60_L	0.821	1.00
41_I	47_I	0.819	1.00
84_M	193_V	0.816	1.00
113_L	175_Q	0.815	1.00
277_V	290_I	0.814	1.00
208_V	263_L	0.809	1.00
244_R	282_D	0.804	1.00
63_S	87_S	0.804	1.00
252_V	267_L	0.804	1.00
189_F	193_V	0.801	1.00
18_T	35_I	0.798	1.00
130_I	140_V	0.798	1.00
41_I	194_M	0.796	1.00
253_N	275_I	0.794	1.00
51_H	150_G	0.791	1.00
15_T	34_G	0.790	1.00
156_L	180_A	0.788	1.00
96_L	163_V	0.787	1.00
192_N	197_G	0.786	1.00
271_V	293_P	0.779	1.00
251_K	285_E	0.779	1.00
233_D	239_Y	0.779	1.00
241_Y	290_I	0.778	1.00
49_S	181_I	0.778	1.00
145_A	178_G	0.775	1.00
46_L	85_L	0.772	1.00
106_V	164_V	0.767	1.00
262_D	266_V	0.760	1.00
8_R	92_P	0.755	1.00
277_V	288_L	0.755	1.00
206_I	227_L	0.753	1.00
120_M	144_D	0.753	1.00
232_I	239_Y	0.746	1.00
274_Q	292_V	0.745	1.00
15_T	111_N	0.740	1.00
163_V	183_S	0.739	1.00
249_I	257_V	0.739	1.00
82_L	190_V	0.738	1.00
40_S	46_L	0.736	1.00
266_V	269_E	0.733	1.00
183_S	187_D	0.729	1.00
100_C	106_V	0.729	1.00
213_K	217_T	0.729	1.00
40_S	87_S	0.726	0.99
17_I	68_R	0.725	0.99
238_A	241_Y	0.723	0.99
139_Y	185_L	0.719	0.99
49_S	167_V	0.717	0.99
107_L	118_V	0.713	0.99
135_G	138_I	0.710	0.99
222_R	280_L	0.710	0.99
49_S	81_D	0.709	0.99
111_N	114_G	0.707	0.99
281_R	284_K	0.704	0.99
84_M	190_V	0.701	0.99
192_N	199_Y	0.698	0.99
13_V	155_P	0.696	0.99
167_V	180_A	0.692	0.99
244_R	247_D	0.691	0.99
192_N	195_K	0.688	0.99
254_N	278_K	0.688	0.99
273_S	292_V	0.686	0.99
235_N	240_K	0.683	0.99
209_I	228_L	0.682	0.99
53_I	76_I	0.681	0.99
59_I	85_L	0.681	0.99
15_T	116_Y	0.679	0.99
18_T	56_A	0.678	0.99
70_E	88_T	0.677	0.99
252_V	266_V	0.674	0.99
211_L	224_Q	0.674	0.99
171_I	174_A	0.673	0.99
136_L	264_L	0.672	0.99
232_I	242_G	0.671	0.99
211_L	248_I	0.669	0.99
99_E	184_K	0.668	0.99
80_H	185_L	0.666	0.99
202_P	273_S	0.665	0.99
52_V	152_S	0.665	0.99
39_Y	47_I	0.665	0.99
46_L	61_V	0.664	0.99
49_S	52_V	0.663	0.99
284_K	289_S	0.659	0.99
128_R	179_F	0.658	0.99
17_I	60_L	0.657	0.99
286_I	289_S	0.656	0.99
209_I	215_L	0.656	0.99
216_A	221_V	0.654	0.99
231_N	234_P	0.652	0.99
183_S	186_V	0.651	0.99
281_R	288_L	0.651	0.99
54_S	76_I	0.650	0.99
208_V	264_L	0.650	0.99
18_T	57_E	0.649	0.99
193_V	199_Y	0.645	0.99
210_K	261_I	0.645	0.99
149_P	173_E	0.645	0.99
206_I	243_I	0.645	0.99
203_Y	208_V	0.644	0.99
129_A	140_V	0.643	0.99
146_A	174_A	0.642	0.99
204_V	292_V	0.639	0.99
42_G	86_R	0.636	0.99
184_K	187_D	0.635	0.99
165_G	180_A	0.632	0.99
106_V	120_M	0.631	0.99
196_F	199_Y	0.630	0.99
210_K	227_L	0.626	0.98
15_T	35_I	0.625	0.98
279_M	287_E	0.625	0.98
236_G	239_Y	0.624	0.98
67_F	89_I	0.623	0.98
253_N	273_S	0.618	0.98
3_E	6_V	0.618	0.98
43_K	92_P	0.618	0.98
17_I	35_I	0.618	0.98
158_N	164_V	0.618	0.98
107_L	120_M	0.616	0.98
109_V	157_I	0.615	0.98
215_L	218_Y	0.615	0.98
212_N	216_A	0.615	0.98
69_E	91_L	0.614	0.98
67_F	90_E	0.613	0.98
148_N	151_N	0.611	0.98
63_S	91_L	0.609	0.98
138_I	168_T	0.609	0.98
18_T	34_G	0.609	0.98
40_S	93_S	0.608	0.98
75_A	189_F	0.607	0.98
155_P	167_V	0.606	0.98
237_S	241_Y	0.606	0.98
264_L	267_L	0.604	0.98
47_I	82_L	0.602	0.98
211_L	221_V	0.602	0.98
113_L	170_M	0.600	0.98
260_P	264_L	0.596	0.98
35_I	115_L	0.595	0.98
262_D	265_A	0.594	0.98
134_N	138_I	0.594	0.98
48_T	83_A	0.593	0.98
131_M	135_G	0.590	0.98
255_Q	269_E	0.587	0.98
143_T	180_A	0.584	0.98
257_V	263_L	0.584	0.98
53_I	59_I	0.583	0.98
11_P	64_E	0.582	0.98
124_S	142_Q	0.581	0.98
264_L	268_E	0.580	0.98
41_I	96_L	0.577	0.97
275_I	290_I	0.577	0.97
151_N	154_G	0.577	0.97
169_A	172_R	0.573	0.97
20_Q	57_E	0.572	0.97
215_L	219_L	0.571	0.97
200_I	292_V	0.571	0.97
265_A	269_E	0.568	0.97
130_I	136_L	0.565	0.97
140_V	168_T	0.565	0.97
80_H	138_I	0.564	0.97
251_K	287_E	0.561	0.97
97_A	100_C	0.560	0.97
125_S	128_R	0.560	0.97
257_V	277_V	0.559	0.97
204_V	263_L	0.559	0.97
211_L	216_A	0.556	0.97
244_R	286_I	0.555	0.97
263_L	277_V	0.554	0.97
49_S	152_S	0.554	0.97
4_D	7_E	0.553	0.97
43_K	89_I	0.551	0.97
80_H	199_Y	0.550	0.97
20_Q	55_N	0.550	0.97
188_S	269_E	0.548	0.97
20_Q	33_E	0.546	0.96
37_S	112_P	0.545	0.96
272_G	291_P	0.545	0.96
238_A	242_G	0.544	0.96
81_D	150_G	0.544	0.96
20_Q	34_G	0.542	0.96
49_S	151_N	0.542	0.96
99_E	160_R	0.540	0.96
239_Y	244_R	0.537	0.96
100_C	184_K	0.537	0.96
229_V	288_L	0.537	0.96
106_V	156_L	0.536	0.96
148_N	176_N	0.536	0.96
53_I	83_A	0.536	0.96
96_L	186_V	0.536	0.96
16_I	38_G	0.533	0.96
41_I	45_I	0.533	0.96
53_I	56_A	0.532	0.96
17_I	33_E	0.530	0.96
142_Q	148_N	0.529	0.96
102_T	118_V	0.528	0.96
124_S	128_R	0.527	0.96
109_V	118_V	0.524	0.96
232_I	238_A	0.523	0.95
8_R	11_P	0.522	0.95
239_Y	242_G	0.522	0.95
37_S	111_N	0.522	0.95
188_S	270_M	0.521	0.95
252_V	257_V	0.521	0.95
130_I	169_A	0.521	0.95
100_C	183_S	0.521	0.95
227_L	260_P	0.520	0.95
82_L	186_V	0.519	0.95
115_L	130_I	0.519	0.95
221_V	248_I	0.519	0.95
113_L	177_I	0.517	0.95
185_L	189_F	0.515	0.95
243_I	247_D	0.515	0.95
6_V	109_V	0.514	0.95
90_E	93_S	0.511	0.95
232_I	241_Y	0.511	0.95
111_N	179_F	0.509	0.95
62_I	66_G	0.508	0.95
189_F	199_Y	0.508	0.95
187_D	190_V	0.508	0.95
216_A	219_L	0.507	0.95
141_V	156_L	0.506	0.95
94_L	183_S	0.505	0.95
104_E	158_N	0.504	0.94
10_T	102_T	0.504	0.94
205_G	236_G	0.504	0.94
131_M	136_L	0.503	0.94
172_R	175_Q	0.502	0.94
36_G	51_H	0.502	0.94
188_S	191_K	0.500	0.94
252_V	292_V	0.500	0.94

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ky9A	5	0.9764	100	0.253	Contact Map
3pv2A	6	0.9461	100	0.256	Contact Map
3stjA	6	0.963	100	0.258	Contact Map
4a8cA	5	0.9731	100	0.266	Contact Map
1lcyA	3	0.9226	100	0.306	Contact Map
4flnA	5	0.9764	100	0.306	Contact Map
1te0A	6	0.9933	100	0.311	Contact Map
4ri0A	3	0.9495	100	0.315	Contact Map
3qo6A	5	0.9832	100	0.323	Contact Map
3numA	3	0.5892	100	0.324	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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