GREMLIN Database
Q97VK9 - Dipeptide ABC transporter ATP binding protein (DppF-3)
UniProt: Q97VK9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (267)
Sequences: 41940 (27287)
Seq/√Len: 1669.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_E222_R4.7461.00
97_H172_D3.7751.00
36_R39_D3.2201.00
26_S40_N3.1391.00
46_R49_E2.9621.00
78_N85_E2.9461.00
51_L224_I2.9351.00
236_N239_E2.8831.00
222_R234_E2.8711.00
52_G220_S2.8601.00
25_E78_N2.8371.00
23_I44_E2.7161.00
217_R238_K2.5611.00
224_I231_I2.5521.00
82_M172_D2.5371.00
39_D230_K2.3681.00
65_G209_I2.3241.00
28_A32_P2.3241.00
113_M117_D2.2701.00
130_R133_K2.2521.00
235_G240_V2.2241.00
47_K172_D2.2231.00
134_L168_A2.1851.00
130_R170_E2.1251.00
65_G175_I2.0521.00
28_A31_P1.9981.00
235_G239_E1.9511.00
52_G216_A1.9411.00
132_K142_Y1.9281.00
85_E88_D1.9231.00
25_E80_I1.8681.00
91_I94_V1.8611.00
148_K152_E1.8381.00
224_I234_E1.8131.00
133_K137_E1.7871.00
210_T216_A1.7801.00
132_K146_K1.7781.00
145_V148_K1.7211.00
116_K120_R1.7081.00
23_I80_I1.6161.00
43_V224_I1.6071.00
91_I95_R1.6001.00
116_K147_D1.5821.00
45_I51_L1.5731.00
120_R131_V1.5701.00
144_Y148_K1.5661.00
82_M97_H1.5561.00
196_V218_Y1.5511.00
198_L204_L1.5351.00
43_V64_L1.5261.00
116_K146_K1.5131.00
239_E243_E1.5121.00
90_N93_H1.4501.00
128_E132_K1.4451.00
116_K128_E1.4371.00
114_K117_D1.4251.00
120_R127_R1.4191.00
192_L215_V1.4051.00
30_E33_I1.4041.00
49_E221_D1.3481.00
119_V135_L1.3441.00
101_V176_L1.3421.00
24_L43_V1.3361.00
117_D120_R1.3341.00
249_T253_L1.3311.00
51_L222_R1.3261.00
70_T73_K1.3251.00
134_L138_V1.3161.00
129_E133_K1.3151.00
281_C287_C1.3121.00
118_I165_R1.3021.00
170_E204_L1.2981.00
196_V199_Q1.2951.00
69_A100_M1.2871.00
50_V199_Q1.2821.00
99_H171_P1.2711.00
26_S42_S1.2701.00
153_L161_V1.2621.00
250_Q254_S1.2581.00
237_T248_Y1.2471.00
113_M121_E1.2401.00
112_R151_R1.2391.00
53_V207_L1.2371.00
50_V220_S1.2371.00
41_V64_L1.2231.00
132_K136_E1.2231.00
195_L206_Y1.2061.00
287_C294_C1.2051.00
128_E146_K1.1851.00
114_K147_D1.1661.00
64_L226_M1.1591.00
51_L234_E1.1541.00
133_K136_E1.1511.00
279_S284_N1.1491.00
84_M89_R1.1481.00
176_L206_Y1.1471.00
47_K82_M1.1461.00
50_V206_Y1.1401.00
287_C291_M1.1391.00
183_L191_I1.1371.00
124_K127_R1.1341.00
67_V74_P1.1171.00
174_L204_L1.1171.00
69_A175_I1.1151.00
120_R128_E1.1121.00
39_D282_R1.1101.00
70_T91_I1.1071.00
119_V168_A1.1011.00
38_L67_V1.0821.00
223_V237_T1.0811.00
31_P34_Y1.0781.00
66_K71_L1.0781.00
53_V224_I1.0781.00
188_Q212_N1.0781.00
250_Q289_F1.0771.00
135_L146_K1.0751.00
199_Q206_Y1.0691.00
47_K203_K1.0681.00
244_P249_T1.0651.00
45_I173_F1.0641.00
23_I26_S1.0621.00
127_R131_V1.0611.00
80_I85_E1.0611.00
99_H166_A1.0581.00
84_M93_H1.0521.00
53_V64_L1.0501.00
238_K242_S1.0501.00
123_M168_A1.0491.00
46_R205_T1.0481.00
137_E197_D1.0421.00
134_L164_A1.0371.00
208_F220_S1.0241.00
230_K282_R1.0241.00
239_E242_S1.0201.00
46_R222_R1.0161.00
141_D144_Y1.0161.00
278_P284_N1.0141.00
145_V153_L1.0141.00
254_S265_K1.0131.00
139_G190_Q1.0111.00
28_A63_T1.0091.00
25_E44_E0.9971.00
67_V72_E0.9881.00
208_F219_I0.9881.00
174_L206_Y0.9811.00
136_E142_Y0.9791.00
284_N290_A0.9711.00
29_R32_P0.9611.00
126_K129_E0.9571.00
59_S226_M0.9491.00
70_T94_V0.9411.00
130_R134_L0.9401.00
45_I205_T0.9371.00
283_F287_C0.9341.00
188_Q215_V0.9331.00
109_I158_T0.9331.00
110_N113_M0.9311.00
128_E147_D0.9301.00
67_V79_L0.9301.00
281_C294_C0.9271.00
40_N230_K0.9271.00
290_A294_C0.9261.00
116_K131_V0.9201.00
125_E129_E0.9191.00
175_I207_L0.9171.00
134_L137_E0.9171.00
68_L207_L0.9161.00
278_P285_P0.9151.00
284_N287_C0.9141.00
273_S276_N0.9131.00
178_E211_H0.9031.00
135_L140_L0.8981.00
30_E75_T0.8961.00
155_G160_R0.8961.00
285_P288_P0.8941.00
277_P282_R0.8921.00
126_K130_R0.8891.00
247_P250_Q0.8871.00
113_M118_I0.8871.00
241_I244_P0.8811.00
122_A165_R0.8801.00
139_G197_D0.8781.00
282_R285_P0.8761.00
268_S272_P0.8741.00
29_R36_R0.8741.00
67_V75_T0.8661.00
38_L41_V0.8661.00
189_A193_N0.8641.00
98_I173_F0.8631.00
127_R130_R0.8631.00
66_K72_E0.8611.00
54_V225_I0.8581.00
26_S76_G0.8521.00
87_N90_N0.8481.00
136_E141_D0.8451.00
220_S223_V0.8451.00
199_Q221_D0.8431.00
54_V216_A0.8431.00
288_P291_M0.8351.00
131_V134_L0.8291.00
291_M294_C0.8211.00
41_V231_I0.8201.00
51_L207_L0.8201.00
196_V219_I0.8181.00
274_L277_P0.8161.00
225_I240_V0.8151.00
240_V249_T0.8101.00
119_V131_V0.8091.00
255_S258_E0.8081.00
89_R94_V0.8071.00
225_I244_P0.7981.00
199_Q204_L0.7971.00
115_V153_L0.7961.00
192_L218_Y0.7941.00
45_I207_L0.7901.00
284_N288_P0.7871.00
136_E143_N0.7831.00
101_V163_I0.7771.00
176_L195_L0.7771.00
227_Y232_V0.7741.00
237_T241_I0.7731.00
264_L267_P0.7721.00
193_N197_D0.7701.00
149_Y152_E0.7681.00
150_P161_V0.7681.00
24_L68_L0.7681.00
30_E63_T0.7671.00
122_A169_K0.7591.00
116_K143_N0.7571.00
138_V164_A0.7561.00
25_E42_S0.7561.00
142_Y145_V0.7531.00
268_S288_P0.7501.00
85_E89_R0.7481.00
289_F292_S0.7451.00
50_V196_V0.7431.00
173_F207_L0.7431.00
115_V161_V0.7411.00
30_E67_V0.7401.00
277_P280_G0.7341.00
29_R34_Y0.7331.00
280_G284_N0.7311.00
89_R93_H0.7301.00
81_F97_H0.7301.00
124_K128_E0.7291.00
269_G272_P0.7271.00
281_C286_R0.7261.00
280_G283_F0.7221.00
71_L102_F0.7191.00
263_E266_P0.7151.00
180_T215_V0.7091.00
31_P36_R0.7071.00
153_L157_Q0.7061.00
109_I118_I0.7021.00
56_E59_S0.7011.00
134_L167_L0.7001.00
227_Y230_K0.7001.00
283_F286_R0.7001.00
84_M97_H0.7001.00
73_K87_N0.6991.00
48_G205_T0.6981.00
263_E267_P0.6931.00
194_L197_D0.6921.00
287_C290_A0.6911.00
173_F205_T0.6871.00
272_P278_P0.6861.00
276_N279_S0.6851.00
81_F173_F0.6831.00
248_Y251_S0.6831.00
57_S178_E0.6801.00
215_V219_I0.6771.00
248_Y252_L0.6741.00
94_V98_I0.6731.00
257_P260_G0.6691.00
101_V166_A0.6681.00
251_S255_S0.6651.00
233_E243_E0.6651.00
231_I234_E0.6651.00
114_K149_Y0.6641.00
243_E246_H0.6631.00
274_L278_P0.6621.00
37_A63_T0.6571.00
68_L79_L0.6551.00
50_V208_F0.6531.00
109_I161_V0.6521.00
281_C284_N0.6511.00
286_R291_M0.6481.00
286_R294_C0.6471.00
78_N88_D0.6461.00
283_F291_M0.6451.00
130_R137_E0.6441.00
24_L28_A0.6431.00
281_C285_P0.6431.00
286_R290_A0.6411.00
129_E132_K0.6401.00
86_V89_R0.6401.00
134_L140_L0.6341.00
279_S285_P0.6331.00
81_F86_V0.6311.00
210_T215_V0.6291.00
114_K118_I0.6271.00
275_I288_P0.6251.00
123_M130_R0.6251.00
270_E274_L0.6251.00
69_A98_I0.6221.00
216_A220_S0.6201.00
128_E131_V0.6191.00
167_L204_L0.6171.00
118_I150_P0.6161.00
256_V259_L0.6151.00
119_V122_A0.6131.00
273_S277_P0.6131.00
284_N291_M0.6071.00
213_I241_I0.6061.00
255_S259_L0.6021.00
116_K119_V0.6021.00
214_A218_Y0.5991.00
220_S237_T0.5991.00
142_Y146_K0.5971.00
50_V219_I0.5961.00
252_L256_V0.5921.00
108_S162_A0.5911.00
266_P270_E0.5901.00
43_V51_L0.5881.00
145_V157_Q0.5861.00
47_K205_T0.5861.00
90_N94_V0.5861.00
140_L145_V0.5861.00
140_L157_Q0.5851.00
30_E34_Y0.5851.00
235_G241_I0.5851.00
290_A293_V0.5831.00
86_V98_I0.5821.00
274_L280_G0.5801.00
193_N196_V0.5791.00
232_V282_R0.5781.00
105_P162_A0.5771.00
172_D204_L0.5761.00
131_V146_K0.5751.00
271_V274_L0.5751.00
196_V200_K0.5741.00
40_N76_G0.5731.00
247_P251_S0.5721.00
50_V221_D0.5711.00
286_R289_F0.5701.00
38_L64_L0.5681.00
154_S157_Q0.5681.00
57_S183_L0.5641.00
129_E136_E0.5641.00
29_R75_T0.5641.00
282_R288_P0.5641.00
66_K100_M0.5641.00
288_P292_S0.5631.00
282_R294_C0.5631.00
273_S278_P0.5591.00
132_K143_N0.5571.00
88_D91_I0.5561.00
275_I279_S0.5521.00
253_L256_V0.5511.00
78_N87_N0.5481.00
193_N218_Y0.5481.00
74_P79_L0.5461.00
28_A74_P0.5461.00
237_T240_V0.5431.00
261_K266_P0.5431.00
276_N280_G0.5401.00
233_E245_M0.5401.00
115_V119_V0.5381.00
281_C288_P0.5361.00
56_E227_Y0.5341.00
256_V260_G0.5331.00
125_E128_E0.5311.00
272_P276_N0.5281.00
233_E244_P0.5281.00
271_V285_P0.5281.00
285_P290_A0.5271.00
270_E273_S0.5261.00
62_T66_K0.5261.00
120_R146_K0.5261.00
163_I191_I0.5251.00
243_E247_P0.5231.00
127_R132_K0.5221.00
250_Q253_L0.5211.00
120_R123_M0.5211.00
240_V244_P0.5191.00
287_C292_S0.5191.00
274_L279_S0.5181.00
278_P282_R0.5171.00
275_I278_P0.5161.00
251_S254_S0.5161.00
246_H249_T0.5121.00
185_A189_A0.5101.00
148_K153_L0.5081.00
199_Q203_K0.5071.00
118_I122_A0.5051.00
135_L138_V0.5031.00
283_F288_P0.5021.00
119_V161_V0.5011.00
57_S187_V0.5001.00
274_L282_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ry2A 2 0.7399 100 0.223 Contact Map
4f4cA 1 0.7337 100 0.226 Contact Map
3tuiC 2 0.9288 100 0.245 Contact Map
4mrsA 2 0.7988 100 0.247 Contact Map
4q4hB 1 0.7709 100 0.248 Contact Map
4u00A 1 0.7214 100 0.248 Contact Map
4q9hA 1 0.774 100 0.249 Contact Map
4ymuJ 2 0.7152 100 0.251 Contact Map
4a82A 2 0.7709 100 0.252 Contact Map
3zdqA 2 0.7337 100 0.252 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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