GREMLIN Database
Q97VK8 - Dipeptide ABC transporter ATP binding protein (DppD-3)
UniProt: Q97VK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (252)
Sequences: 66392 (39776)
Seq/√Len: 2505.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_E230_R3.8521.00
8_Q32_D3.1261.00
92_W180_K3.1191.00
11_N28_D3.0361.00
24_K27_S2.9321.00
39_V232_V2.9301.00
10_R69_D2.8971.00
230_R242_D2.6951.00
14_V55_A2.6321.00
34_E37_E2.5691.00
15_Y24_K2.5531.00
40_G228_S2.5481.00
153_I156_R2.4801.00
8_Q71_I2.4641.00
244_K247_E2.4331.00
69_D76_N2.4101.00
73_D180_K2.3931.00
13_N67_Q2.2651.00
232_V239_I2.2591.00
27_S238_R2.1831.00
10_R71_I2.1301.00
13_N28_D2.0861.00
9_I12_L2.0371.00
13_N24_K2.0251.00
232_V242_D2.0041.00
139_I154_I1.9851.00
108_K112_S1.9691.00
243_G247_E1.9441.00
130_E133_S1.8871.00
35_K180_K1.8831.00
225_Y246_E1.8221.00
137_D178_K1.7821.00
137_D140_E1.7801.00
16_Y51_T1.7791.00
53_G217_I1.7761.00
53_G183_I1.7741.00
149_D152_S1.7631.00
243_G248_V1.7511.00
16_Y25_V1.6701.00
14_V60_L1.6211.00
156_R160_Q1.6171.00
148_P152_S1.5881.00
140_E144_D1.5671.00
135_M139_I1.5561.00
76_N79_K1.5531.00
15_Y22_W1.5521.00
141_V176_L1.5371.00
123_Q129_A1.5291.00
218_T224_A1.5271.00
115_L134_L1.5221.00
111_G154_I1.5141.00
17_N22_W1.5111.00
111_G155_D1.5091.00
111_G115_L1.4981.00
12_L62_P1.4861.00
40_G224_A1.4741.00
11_N30_N1.4721.00
9_I31_L1.4701.00
73_D92_W1.4541.00
247_E251_S1.4481.00
13_N27_S1.4331.00
14_V63_N1.4241.00
58_R85_L1.4051.00
204_K226_V1.3831.00
184_A214_I1.3781.00
31_L232_V1.3611.00
206_L212_T1.3511.00
178_K212_T1.3471.00
15_Y63_N1.3411.00
37_E229_D1.3381.00
33_V39_V1.3321.00
109_K112_S1.3321.00
153_I161_L1.3291.00
115_L138_V1.3191.00
119_K134_L1.3111.00
9_I56_I1.2801.00
31_L52_L1.2691.00
85_L89_R1.2601.00
114_L142_L1.2591.00
255_P258_Q1.2551.00
139_I143_K1.2511.00
38_I207_N1.2411.00
34_E230_R1.2401.00
39_V242_D1.2391.00
39_V230_R1.2281.00
58_R61_P1.2231.00
57_S95_M1.2081.00
136_R140_E1.2051.00
204_K227_V1.2021.00
101_L166_V1.1951.00
71_I76_N1.1921.00
133_S136_R1.1831.00
29_V52_L1.1721.00
254_H257_T1.1651.00
38_I214_I1.1631.00
200_V223_L1.1581.00
10_R30_N1.1531.00
10_R32_D1.1511.00
109_K155_D1.1511.00
112_S115_L1.1461.00
152_S156_R1.1451.00
6_V73_D1.1351.00
135_M154_I1.1291.00
142_L154_I1.1291.00
111_G135_M1.1231.00
255_P259_G1.1081.00
38_I228_S1.1021.00
161_L169_I1.0681.00
75_V80_L1.0671.00
204_K207_N1.0651.00
246_E250_K1.0651.00
113_Q173_M1.0501.00
35_K73_D1.0491.00
139_I149_D1.0481.00
80_L85_L1.0471.00
18_T22_W1.0451.00
96_I184_A1.0391.00
55_A62_P1.0351.00
132_E136_R1.0271.00
258_Q262_A1.0241.00
107_V159_H1.0221.00
231_I245_V1.0191.00
140_E143_K1.0141.00
207_N214_I1.0091.00
52_L234_M1.0051.00
245_V256_Y1.0011.00
143_K148_P0.9971.00
257_T261_V0.9891.00
149_D154_I0.9871.00
41_V215_L0.9871.00
111_G138_V0.9831.00
115_L119_K0.9801.00
203_F214_I0.9701.00
131_E135_M0.9671.00
41_V52_L0.9661.00
60_L63_N0.9651.00
56_I215_L0.9591.00
148_P153_I0.9571.00
247_E250_K0.9541.00
110_V161_L0.9481.00
182_L214_I0.9411.00
54_H59_I0.9371.00
114_L176_L0.9371.00
182_L212_T0.9311.00
11_N67_Q0.9291.00
35_K211_N0.9291.00
133_S137_D0.9251.00
202_L205_Q0.9251.00
196_Q220_D0.9171.00
144_D205_Q0.9171.00
146_R205_Q0.9141.00
41_V232_V0.9141.00
26_L55_A0.9121.00
197_A201_N0.9101.00
94_F179_P0.9091.00
115_L135_M0.9081.00
137_D141_V0.9061.00
122_Y129_A0.9061.00
54_H60_L0.9031.00
108_K116_E0.9001.00
18_T23_V0.9001.00
88_Y93_V0.8991.00
130_E134_L0.8981.00
241_E251_S0.8971.00
9_I70_I0.8941.00
184_A203_F0.8831.00
141_V144_D0.8831.00
87_K90_G0.8811.00
157_Y160_Q0.8801.00
57_S183_I0.8801.00
118_V176_L0.8791.00
191_L199_V0.8761.00
141_V172_S0.8721.00
143_K149_D0.8701.00
34_E213_S0.8651.00
109_K157_Y0.8651.00
14_V51_T0.8611.00
118_V122_Y0.8491.00
33_V181_L0.8461.00
104_L166_V0.8441.00
15_Y27_S0.8441.00
266_S269_K0.8421.00
201_N226_V0.8391.00
129_A134_L0.8381.00
196_Q223_L0.8321.00
38_I204_K0.8311.00
7_L56_I0.8261.00
108_K113_Q0.8251.00
44_E235_Y0.8221.00
6_V35_K0.8191.00
94_F174_A0.8191.00
121_R177_L0.8171.00
149_D153_I0.8171.00
239_I242_D0.8161.00
6_V32_D0.8121.00
240_M254_H0.8091.00
230_R240_M0.8051.00
186_E219_H0.8021.00
235_Y240_M0.8021.00
38_I216_F0.8011.00
207_N229_D0.8001.00
110_V169_I0.7981.00
96_I171_I0.7941.00
38_I227_V0.7931.00
47_S234_M0.7911.00
145_L172_S0.7901.00
25_V51_T0.7891.00
134_L138_V0.7861.00
6_V34_E0.7831.00
12_L55_A0.7781.00
158_P169_I0.7771.00
123_Q130_E0.7741.00
272_K275_A0.7731.00
248_V257_T0.7701.00
245_V249_L0.7681.00
241_E252_P0.7611.00
55_A60_L0.7591.00
9_I52_L0.7581.00
161_L165_Q0.7581.00
28_D238_R0.7531.00
26_L29_V0.7481.00
201_N204_K0.7481.00
33_V213_S0.7481.00
42_V224_A0.7421.00
75_V92_W0.7421.00
131_E134_L0.7401.00
136_R139_I0.7341.00
146_R198_Q0.7331.00
259_G262_A0.7301.00
28_D67_Q0.7291.00
93_V181_L0.7281.00
14_V26_L0.7251.00
181_L213_S0.7241.00
216_F227_V0.7231.00
259_G263_S0.7211.00
183_I215_L0.7201.00
118_V121_R0.7201.00
216_F228_S0.7191.00
55_A70_I0.7181.00
235_Y259_G0.7171.00
81_K85_L0.7131.00
146_R149_D0.7121.00
188_T199_V0.7111.00
105_N108_K0.7101.00
29_V239_I0.7091.00
135_M138_V0.7081.00
122_Y137_D0.7081.00
81_K87_K0.7021.00
235_Y238_R0.7021.00
72_V92_W0.7011.00
11_N14_V0.7001.00
221_I249_L0.7001.00
228_S231_I0.6901.00
200_V226_V0.6891.00
233_V252_P0.6881.00
33_V215_L0.6841.00
69_D78_A0.6761.00
204_K208_K0.6721.00
262_A274_T0.6721.00
117_A177_L0.6721.00
96_I174_A0.6701.00
241_E253_M0.6671.00
228_S245_V0.6621.00
233_V248_V0.6621.00
39_V215_L0.6611.00
119_K131_E0.6581.00
117_A173_M0.6561.00
50_S54_H0.6561.00
61_P78_A0.6511.00
111_G139_I0.6511.00
252_P257_T0.6501.00
26_L52_L0.6501.00
241_E248_V0.6461.00
38_I229_D0.6451.00
77_L88_Y0.6451.00
80_L88_Y0.6421.00
223_L227_V0.6421.00
57_S93_V0.6401.00
63_N67_Q0.6381.00
263_S266_S0.6371.00
138_V154_I0.6341.00
201_N205_Q0.6291.00
198_Q201_N0.6281.00
72_V88_Y0.6271.00
7_L181_L0.6251.00
99_N102_N0.6251.00
71_I74_G0.6241.00
16_Y60_L0.6241.00
138_V141_V0.6201.00
188_T223_L0.6191.00
42_V233_V0.6171.00
153_I165_Q0.6171.00
114_L138_V0.6121.00
163_G168_R0.6121.00
135_M155_D0.6121.00
258_Q261_V0.6101.00
123_Q134_L0.6061.00
147_L165_Q0.6041.00
59_I97_F0.6031.00
109_K113_Q0.6011.00
76_N80_L0.6001.00
69_D79_K0.6001.00
225_Y249_L0.5991.00
72_V181_L0.5981.00
138_V142_L0.5981.00
247_E253_M0.5971.00
180_K212_T0.5971.00
251_S254_H0.5931.00
129_A133_S0.5931.00
218_T223_L0.5911.00
7_L72_V0.5901.00
6_V72_V0.5871.00
102_N166_V0.5801.00
113_Q158_P0.5801.00
167_Q190_A0.5801.00
56_I70_I0.5801.00
256_Y259_G0.5791.00
273_L276_I0.5741.00
54_H95_M0.5721.00
181_L215_L0.5711.00
15_Y67_Q0.5701.00
200_V227_V0.5691.00
87_K92_W0.5681.00
256_Y260_L0.5651.00
224_A228_S0.5641.00
225_Y245_V0.5621.00
267_G270_N0.5621.00
141_V175_L0.5611.00
6_V213_S0.5601.00
15_Y25_V0.5591.00
118_V129_A0.5591.00
117_A120_I0.5581.00
133_S142_L0.5581.00
260_L264_I0.5571.00
98_Q163_G0.5561.00
132_E135_M0.5541.00
162_S165_Q0.5531.00
175_L212_T0.5511.00
116_E120_I0.5511.00
73_D76_N0.5511.00
249_L252_P0.5501.00
251_S255_P0.5481.00
75_V88_Y0.5431.00
263_S267_G0.5421.00
232_V240_M0.5411.00
77_L93_V0.5411.00
45_S186_E0.5401.00
243_G252_P0.5391.00
6_V181_L0.5361.00
123_Q133_S0.5351.00
62_P78_A0.5351.00
104_L113_Q0.5321.00
171_I199_V0.5321.00
55_A63_N0.5291.00
134_L139_I0.5271.00
32_D242_D0.5271.00
224_A231_I0.5271.00
255_P262_A0.5261.00
254_H258_Q0.5261.00
36_G213_S0.5241.00
15_Y18_T0.5231.00
44_E47_S0.5221.00
37_E242_D0.5211.00
118_V123_Q0.5201.00
111_G114_L0.5161.00
104_L169_I0.5161.00
58_R78_A0.5151.00
70_I78_A0.5111.00
224_A245_V0.5111.00
11_N68_G0.5111.00
241_E257_T0.5101.00
24_K28_D0.5091.00
8_Q30_N0.5081.00
137_D144_D0.5041.00
141_V145_L0.5031.00
207_N212_T0.5021.00
156_R161_L0.5021.00
115_L123_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fwiB 1 0.9383 100 0.196 Contact Map
3tuiC 2 0.9414 100 0.207 Contact Map
4ry2A 2 0.7407 100 0.216 Contact Map
4f4cA 1 0.7191 100 0.227 Contact Map
4u00A 1 0.7438 100 0.236 Contact Map
2yyzA 1 0.8981 100 0.236 Contact Map
2oljA 2 0.7469 100 0.236 Contact Map
1b0uA 2 0.7623 100 0.236 Contact Map
4mkiB 2 0.8765 100 0.237 Contact Map
4ymuJ 2 0.7407 100 0.237 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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