GREMLIN Database
Q97VK7 - Dipeptide ABC transporter permease protein (DppC-3)
UniProt: Q97VK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (261)
Sequences: 28844 (18263)
Seq/√Len: 1130.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_L72_P2.7711.00
65_N68_L2.7231.00
182_T209_I2.7221.00
33_W73_P2.6671.00
129_D179_R2.6141.00
195_K201_R2.4091.00
185_I190_Y2.4081.00
199_V203_S2.3811.00
203_S207_R2.3531.00
117_L132_L2.3271.00
185_I188_M2.3101.00
105_V163_I2.2991.00
98_R237_F2.2891.00
200_S203_S2.2811.00
202_I206_Y2.2731.00
109_S167_A2.2511.00
25_I74_S2.2391.00
75_S78_L2.1151.00
62_F67_Q2.1081.00
11_L15_I2.0991.00
189_D192_S2.0851.00
251_E255_N2.0711.00
38_G61_P2.0661.00
191_I209_I2.0171.00
191_I204_L2.0021.00
91_R252_M1.9571.00
119_I182_T1.9431.00
222_A285_G1.9381.00
124_L201_R1.8721.00
120_L124_L1.8631.00
112_I116_I1.8451.00
87_D90_S1.8191.00
124_L128_V1.8041.00
174_Y224_D1.8011.00
123_Y201_R1.7631.00
82_N86_E1.7551.00
34_S96_L1.7261.00
190_Y212_N1.7211.00
26_I74_S1.7201.00
122_G182_T1.7091.00
185_I213_A1.7081.00
127_I131_I1.7041.00
79_L269_F1.6631.00
113_I171_W1.6161.00
84_E91_R1.6131.00
186_K209_I1.5951.00
113_I116_I1.5831.00
89_L93_L1.5741.00
69_A72_P1.5741.00
101_F105_V1.5631.00
110_A170_W1.5571.00
120_L128_V1.5571.00
77_F87_D1.5511.00
88_I269_F1.5431.00
181_Q184_R1.5291.00
163_I167_A1.5231.00
68_L71_H1.5221.00
94_Y97_P1.5051.00
132_L175_A1.5011.00
111_I221_A1.5001.00
136_T175_A1.4971.00
83_A255_N1.4931.00
128_V132_L1.4931.00
256_G266_W1.4851.00
123_Y205_F1.4611.00
86_E90_S1.4601.00
253_A270_P1.4311.00
184_R188_M1.4221.00
107_V221_A1.4181.00
114_G174_Y1.4181.00
71_H74_S1.4041.00
118_G122_G1.3871.00
22_L26_I1.3861.00
193_A197_S1.3631.00
134_R137_D1.3261.00
118_G178_Y1.3211.00
179_R183_L1.3141.00
114_G178_Y1.3081.00
127_I130_E1.3011.00
146_I150_A1.2801.00
117_L175_A1.2801.00
185_I191_I1.2771.00
219_A289_Q1.2701.00
98_R101_F1.2681.00
20_G287_R1.2611.00
17_D279_V1.2601.00
160_F164_L1.2521.00
79_L89_L1.2511.00
122_G186_K1.2481.00
36_I39_I1.2421.00
289_Q293_A1.2421.00
121_A132_L1.2421.00
185_I209_I1.2391.00
119_I205_F1.2361.00
177_F220_Y1.2291.00
167_A171_W1.2241.00
264_W268_L1.2141.00
92_I273_T1.2061.00
151_I165_G1.1961.00
69_A73_P1.1921.00
288_L291_V1.1841.00
218_L292_V1.1811.00
24_L275_L1.1801.00
23_G280_G1.1621.00
102_V232_Y1.1551.00
194_A208_Y1.1521.00
86_E91_R1.1331.00
139_F172_P1.1241.00
194_A204_L1.1141.00
32_I36_I1.1101.00
194_A199_V1.1051.00
23_G287_R1.1031.00
119_I210_F1.1021.00
86_E94_Y1.1001.00
83_A259_G1.1001.00
182_T213_A1.0991.00
178_Y217_V1.0851.00
115_G178_Y1.0851.00
130_E134_R1.0831.00
37_Q94_Y1.0791.00
18_K21_L1.0781.00
178_Y182_T1.0731.00
181_Q185_I1.0701.00
270_P274_I1.0661.00
135_V139_F1.0621.00
24_L28_S1.0601.00
165_G169_V1.0561.00
192_S195_K1.0481.00
15_I21_L1.0471.00
125_G129_D1.0451.00
252_M266_W1.0391.00
116_I119_I1.0371.00
256_G267_A1.0331.00
15_I19_A1.0311.00
158_T161_A1.0241.00
197_S208_Y1.0121.00
27_V280_G1.0101.00
81_T87_D1.0041.00
133_M175_A1.0021.00
142_L147_L1.0011.00
79_L92_I1.0001.00
26_I30_F0.9961.00
203_S206_Y0.9961.00
129_D183_L0.9951.00
171_W175_A0.9911.00
97_P101_F0.9881.00
88_I266_W0.9871.00
287_R291_V0.9861.00
70_F73_P0.9821.00
106_V167_A0.9791.00
90_S94_Y0.9791.00
148_V165_G0.9781.00
66_L69_A0.9741.00
269_F272_L0.9681.00
254_A258_T0.9681.00
195_K204_L0.9651.00
129_D133_M0.9621.00
160_F163_I0.9611.00
95_A252_M0.9591.00
91_R266_W0.9581.00
101_F159_F0.9571.00
88_I252_M0.9541.00
178_Y213_A0.9501.00
215_D289_Q0.9381.00
265_W269_F0.9361.00
101_F104_I0.9301.00
194_A197_S0.9271.00
131_I135_V0.9241.00
280_G284_L0.9241.00
41_E90_S0.9131.00
9_F13_A0.9111.00
199_V204_L0.9071.00
115_G217_V0.9031.00
155_L161_A0.9031.00
106_V110_A0.9021.00
144_A231_T0.9011.00
281_F285_G0.9001.00
19_A22_L0.8971.00
128_V131_I0.8951.00
22_L25_I0.8891.00
218_L285_G0.8871.00
29_L33_W0.8831.00
106_V166_L0.8721.00
201_R204_L0.8711.00
92_I269_F0.8641.00
22_L74_S0.8631.00
125_G186_K0.8621.00
25_I29_L0.8611.00
136_T172_P0.8551.00
164_L167_A0.8531.00
118_G182_T0.8481.00
38_G41_E0.8471.00
77_F81_T0.8471.00
213_A216_P0.8471.00
15_I18_K0.8461.00
17_D283_L0.8451.00
130_E133_M0.8441.00
112_I115_G0.8421.00
70_F74_S0.8381.00
159_F163_I0.8361.00
220_Y224_D0.8351.00
111_I115_G0.8301.00
91_R94_Y0.8291.00
157_A161_A0.8281.00
255_N258_T0.8231.00
23_G27_V0.8211.00
23_G26_I0.8201.00
81_T85_G0.8191.00
93_L97_P0.8171.00
12_K15_I0.8171.00
26_I280_G0.8161.00
166_L231_T0.8151.00
121_A129_D0.8141.00
180_A183_L0.8091.00
96_L277_I0.8071.00
111_I116_I0.8051.00
252_M270_P0.8051.00
201_R205_F0.8041.00
122_G183_L0.8011.00
206_Y209_I0.7971.00
161_A164_L0.7961.00
106_V228_V0.7911.00
90_S93_L0.7851.00
182_T186_K0.7851.00
117_L171_W0.7841.00
37_Q40_L0.7841.00
144_A148_V0.7791.00
111_I174_Y0.7781.00
156_K161_A0.7761.00
43_L90_S0.7761.00
25_I272_L0.7711.00
268_L272_L0.7661.00
192_S196_L0.7661.00
188_M192_S0.7651.00
116_I120_L0.7611.00
105_V108_F0.7591.00
105_V237_F0.7581.00
199_V208_Y0.7561.00
274_I278_V0.7501.00
185_I212_N0.7501.00
33_W93_L0.7451.00
21_L276_I0.7431.00
104_I108_F0.7371.00
255_N259_G0.7341.00
151_I161_A0.7321.00
78_L89_L0.7311.00
254_A257_V0.7261.00
9_F290_D0.7261.00
93_L96_L0.7241.00
269_F273_T0.7231.00
140_L172_P0.7231.00
20_G24_L0.7211.00
41_E94_Y0.7211.00
290_D296_I0.7101.00
65_N69_A0.7101.00
40_L61_P0.7091.00
99_D103_A0.7051.00
202_I205_F0.7041.00
204_L209_I0.7011.00
30_F33_W0.7011.00
62_F68_L0.6961.00
178_Y181_Q0.6951.00
38_G97_P0.6941.00
18_K22_L0.6921.00
181_Q216_P0.6911.00
268_L271_G0.6911.00
109_S163_I0.6901.00
276_I280_G0.6901.00
103_A225_F0.6841.00
125_G187_N0.6791.00
170_W173_T0.6791.00
24_L284_L0.6761.00
114_G118_G0.6761.00
36_I40_L0.6761.00
10_M287_R0.6731.00
42_I89_L0.6721.00
113_I167_A0.6721.00
28_S32_I0.6711.00
222_A281_F0.6691.00
30_F34_S0.6661.00
169_V172_P0.6661.00
14_L18_K0.6591.00
289_Q296_I0.6581.00
42_I90_S0.6581.00
278_V282_V0.6571.00
69_A74_S0.6511.00
125_G130_E0.6501.00
284_L288_L0.6491.00
181_Q213_A0.6471.00
267_A271_G0.6461.00
230_L233_S0.6451.00
92_I270_P0.6451.00
110_A167_A0.6441.00
14_L283_L0.6431.00
30_F277_I0.6421.00
121_A133_M0.6391.00
37_Q41_E0.6361.00
21_L279_V0.6351.00
157_A160_F0.6331.00
162_T232_Y0.6321.00
230_L234_T0.6311.00
133_M136_T0.6261.00
82_N263_Y0.6251.00
100_A104_I0.6221.00
28_S271_G0.6181.00
131_I134_R0.6171.00
43_L76_T0.6121.00
74_S77_F0.6121.00
132_L136_T0.6121.00
21_L25_I0.6111.00
14_L20_G0.6091.00
123_Y186_K0.6071.00
183_L186_K0.6061.00
173_T224_D0.6061.00
78_L87_D0.6051.00
147_L169_V0.6051.00
107_V224_D0.6041.00
123_Y206_Y0.6031.00
113_I117_L0.6011.00
232_Y236_A0.5991.00
231_T234_T0.5981.00
144_A147_L0.5971.00
170_W224_D0.5961.00
174_Y178_Y0.5961.00
19_A23_G0.5951.00
150_A154_P0.5921.00
122_G129_D0.5911.00
74_S78_L0.5901.00
136_T171_W0.5881.00
199_V202_I0.5871.00
124_L205_F0.5871.00
253_A274_I0.5861.00
174_Y220_Y0.5841.00
108_F112_I0.5811.00
228_V231_T0.5781.00
17_D287_R0.5741.00
103_A228_V0.5691.00
96_L100_A0.5661.00
67_Q71_H0.5661.00
233_S251_E0.5651.00
61_P64_Y0.5611.00
26_I276_I0.5611.00
67_Q73_P0.5601.00
139_F171_W0.5591.00
73_P265_W0.5571.00
134_R138_A0.5531.00
161_A165_G0.5531.00
225_F281_F0.5511.00
144_A168_V0.5511.00
233_S254_A0.5491.00
91_R95_A0.5491.00
65_N73_P0.5491.00
114_G175_A0.5471.00
152_T156_K0.5471.00
12_K16_R0.5471.00
111_I217_V0.5461.00
191_I195_K0.5461.00
286_D289_Q0.5451.00
105_V160_F0.5431.00
168_V171_W0.5431.00
43_L77_F0.5411.00
33_W96_L0.5411.00
33_W264_W0.5411.00
252_M255_N0.5391.00
172_P175_A0.5371.00
229_I233_S0.5371.00
133_M137_D0.5341.00
252_M256_G0.5331.00
206_Y211_L0.5331.00
73_P76_T0.5261.00
9_F296_I0.5261.00
173_T220_Y0.5231.00
126_G129_D0.5211.00
164_L168_V0.5211.00
33_W70_F0.5191.00
20_G23_G0.5171.00
233_S255_N0.5171.00
30_F276_I0.5171.00
137_D140_L0.5161.00
25_I28_S0.5151.00
117_L120_L0.5151.00
121_A179_R0.5141.00
61_P65_N0.5141.00
265_W268_L0.5131.00
108_F111_I0.5121.00
167_A170_W0.5111.00
39_I43_L0.5091.00
91_R255_N0.5061.00
219_A222_A0.5031.00
226_G278_V0.5021.00
97_P100_A0.5001.00
126_G130_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.849 99.9 0.605 Contact Map
3tuiA 2 0.6779 99.9 0.633 Contact Map
3d31C 2 0.7752 99.8 0.668 Contact Map
3rlfF 1 0.8792 99.8 0.669 Contact Map
2onkC 2 0.7919 99.8 0.67 Contact Map
4tquN 1 0.8792 99.8 0.677 Contact Map
4ymuD 2 0.7013 99.8 0.678 Contact Map
3rlfG 1 0.8557 99.8 0.682 Contact Map
3hd7A 1 0.1242 4.9 0.964 Contact Map
3j9pD 4 0.7416 4.5 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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