GREMLIN Database
Q97VK6 - Dipeptide ABC transporter permease protein (DppB-3)
UniProt: Q97VK6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 343 (287)
Sequences: 23469 (14807)
Seq/√Len: 874.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_Q70_I3.2041.00
66_Q74_N3.1301.00
32_H71_Q2.9621.00
232_M259_V2.7801.00
77_I81_H2.7421.00
73_I77_I2.6951.00
52_Y56_E2.6291.00
60_K65_D2.5491.00
24_I72_I2.5091.00
123_T139_V2.4571.00
104_R291_Y2.4351.00
245_L251_R2.3881.00
111_P213_V2.3711.00
253_R257_G2.3601.00
296_Y300_Q2.3081.00
235_Y240_F2.2731.00
241_A259_V2.2151.00
37_N59_A2.1741.00
235_Y238_S2.1581.00
136_D229_R2.1461.00
25_I72_I2.1111.00
252_R256_Y2.0841.00
250_S253_R2.0761.00
249_L253_R2.0331.00
97_L297_F2.0121.00
272_A328_A2.0061.00
93_P96_T1.9631.00
69_Y73_I1.9631.00
5_I9_I1.9411.00
115_L217_A1.9371.00
55_L59_A1.8961.00
118_V122_F1.8841.00
54_E57_Q1.8741.00
236_M259_V1.8441.00
51_T54_E1.8321.00
130_N133_K1.8121.00
90_Y97_L1.7761.00
241_A254_V1.7721.00
126_I130_N1.7701.00
57_Q61_Q1.7631.00
7_F11_R1.7621.00
134_P138_L1.7551.00
56_E59_A1.7531.00
20_L319_I1.7381.00
130_N135_L1.7311.00
239_D242_K1.7271.00
128_A232_M1.6271.00
95_I99_G1.6221.00
125_A232_M1.6191.00
70_I74_N1.6171.00
23_L318_G1.6151.00
78_N83_N1.6011.00
56_E60_K1.5911.00
94_V312_G1.5881.00
92_V96_T1.5881.00
130_N251_R1.5851.00
235_Y263_A1.5801.00
126_I135_L1.5791.00
119_I122_F1.5481.00
135_L139_V1.5401.00
74_N77_I1.5311.00
213_V217_A1.5281.00
129_S251_R1.5111.00
107_E111_P1.5101.00
268_V335_L1.5081.00
243_L247_K1.5031.00
119_I221_F1.4991.00
80_L83_N1.4961.00
129_S255_V1.4871.00
224_V274_L1.4651.00
84_F312_G1.4651.00
240_F262_N1.4401.00
21_I72_I1.4361.00
116_S220_S1.4261.00
269_T332_Y1.4161.00
117_V271_I1.4101.00
331_L334_V1.4091.00
298_I313_T1.4031.00
301_A309_S1.4001.00
14_I18_I1.3811.00
235_Y241_A1.3741.00
28_F32_H1.3691.00
37_N40_A1.3581.00
153_L157_I1.3371.00
87_D92_V1.3311.00
58_V62_Y1.3281.00
120_G228_A1.3211.00
66_Q69_Y1.3161.00
104_R107_E1.3161.00
235_Y259_V1.3131.00
92_V100_K1.3101.00
67_P70_I1.2991.00
84_F95_I1.2981.00
74_N78_N1.2941.00
100_K103_P1.2901.00
58_V61_Q1.2891.00
28_F31_I1.2791.00
120_G224_V1.2751.00
229_R233_L1.2721.00
158_L215_A1.2661.00
79_V84_F1.2591.00
92_V97_L1.2441.00
132_N136_D1.2431.00
139_V225_T1.2411.00
124_G128_A1.2321.00
247_K258_V1.2241.00
113_T271_I1.2201.00
6_V9_I1.2201.00
24_I75_Y1.2201.00
63_G66_Q1.2141.00
217_A221_F1.2091.00
70_I73_I1.1941.00
332_Y336_D1.1851.00
128_A236_M1.1811.00
146_T222_G1.1761.00
227_I270_L1.1721.00
21_I25_I1.1691.00
134_P137_Y1.1611.00
127_A139_V1.1581.00
232_M263_A1.1511.00
297_F309_S1.1481.00
210_V214_I1.1451.00
16_A322_I1.1451.00
123_T225_T1.1431.00
124_G228_A1.1381.00
143_Y225_T1.1361.00
276_G321_I1.1321.00
86_I93_P1.1211.00
149_S154_I1.1141.00
25_I29_I1.1091.00
14_I330_I1.1081.00
125_A255_V1.1051.00
89_T304_S1.1021.00
10_I14_I1.0951.00
39_L55_L1.0951.00
265_I332_Y1.0931.00
97_L309_S1.0931.00
215_A219_V1.0871.00
228_A267_L1.0641.00
313_T317_V1.0551.00
29_I32_H1.0551.00
228_A232_M1.0491.00
78_N81_H1.0471.00
13_I17_F1.0411.00
40_A55_L1.0371.00
107_E209_M1.0351.00
299_T303_E1.0331.00
330_I334_V1.0321.00
142_V146_T1.0241.00
96_T100_K1.0161.00
324_A328_A1.0121.00
63_G74_N1.0061.00
57_Q60_K0.9991.00
234_D238_S0.9991.00
231_S234_D0.9981.00
244_S254_V0.9961.00
136_D233_L0.9951.00
244_S249_L0.9871.00
244_S258_V0.9861.00
307_Y311_L0.9651.00
122_F125_A0.9631.00
170_P173_G0.9631.00
112_A217_A0.9621.00
17_F323_I0.9611.00
99_G103_P0.9531.00
245_L254_V0.9491.00
251_R254_V0.9451.00
128_A233_L0.9361.00
155_A215_A0.9331.00
46_T50_A0.9311.00
140_R225_T0.9231.00
97_L100_K0.9221.00
107_E110_I0.9211.00
231_S235_Y0.9181.00
76_I79_V0.9171.00
249_L254_V0.9171.00
125_A260_L0.9171.00
112_A216_I0.9051.00
263_A266_P0.9031.00
300_Q304_S0.9021.00
9_I15_N0.8951.00
151_P285_I0.8921.00
112_A116_S0.8871.00
96_T99_G0.8851.00
20_L322_I0.8851.00
86_I91_K0.8801.00
221_F225_T0.8751.00
16_A326_L0.8721.00
275_F324_A0.8681.00
101_Y297_F0.8641.00
6_V10_I0.8631.00
28_F102_L0.8601.00
214_I217_A0.8541.00
209_M213_V0.8501.00
268_V328_A0.8481.00
121_L228_A0.8471.00
32_H68_L0.8461.00
253_R256_Y0.8461.00
158_L211_L0.8441.00
115_L213_V0.8431.00
60_K66_Q0.8431.00
327_I331_L0.8431.00
24_I315_I0.8421.00
27_V31_I0.8391.00
94_V309_S0.8391.00
46_T58_V0.8381.00
138_L142_V0.8361.00
157_I161_V0.8281.00
21_I76_I0.8251.00
12_R15_N0.8241.00
9_I330_I0.8231.00
111_P291_Y0.8221.00
52_Y55_L0.8191.00
53_T57_Q0.8171.00
132_N137_Y0.8161.00
117_V122_F0.8131.00
323_I327_I0.8131.00
122_F126_I0.8121.00
8_F333_G0.8111.00
13_I326_L0.8101.00
228_A263_A0.8101.00
22_L26_L0.8091.00
45_Y50_A0.8091.00
98_I312_G0.8061.00
297_F301_A0.8041.00
26_L30_M0.8031.00
242_K245_L0.7991.00
87_D306_D0.7971.00
79_V315_I0.7971.00
120_G124_G0.7961.00
137_Y140_R0.7921.00
94_V297_F0.7901.00
124_G232_M0.7871.00
29_I68_L0.7861.00
18_I22_L0.7861.00
300_Q303_E0.7821.00
110_I114_I0.7821.00
256_Y259_V0.7771.00
151_P155_A0.7751.00
113_T275_F0.7741.00
121_L267_L0.7701.00
332_Y339_V0.7701.00
135_L138_L0.7691.00
84_F98_I0.7691.00
105_T109_V0.7661.00
333_G339_V0.7651.00
103_P107_E0.7631.00
254_V259_V0.7631.00
141_G144_L0.7581.00
25_I68_L0.7571.00
82_G93_P0.7571.00
89_T300_Q0.7541.00
27_V32_H0.7491.00
36_P305_L0.7471.00
210_V213_V0.7441.00
251_R255_V0.7441.00
129_S256_Y0.7431.00
301_A310_I0.7421.00
207_H210_V0.7401.00
123_T221_F0.7351.00
32_H307_Y0.7311.00
18_I21_I0.7301.00
77_I80_L0.7301.00
244_S247_K0.7291.00
231_S263_A0.7271.00
162_I211_L0.7241.00
147_W222_G0.7221.00
72_I76_I0.7211.00
276_G324_A0.7201.00
120_G225_T0.7201.00
36_P39_L0.7181.00
228_A231_S0.7171.00
73_I76_I0.7171.00
27_V314_T0.7171.00
112_A282_A0.7111.00
173_G208_H0.7091.00
249_L258_V0.7081.00
99_G102_L0.7061.00
220_S223_I0.7051.00
116_S217_A0.7011.00
98_I316_I0.7001.00
298_I301_A0.7001.00
208_H211_L0.6991.00
143_Y222_G0.6951.00
50_A55_L0.6931.00
53_T56_E0.6921.00
154_I218_L0.6901.00
155_A288_I0.6891.00
21_I323_I0.6881.00
297_F313_T0.6831.00
319_I323_I0.6831.00
137_Y141_G0.6831.00
312_G316_I0.6791.00
108_L286_E0.6781.00
98_I313_T0.6781.00
317_V321_I0.6771.00
139_V143_Y0.6741.00
106_L110_I0.6731.00
15_N19_T0.6731.00
311_L315_I0.6731.00
82_G86_I0.6711.00
127_A136_D0.6711.00
39_L59_A0.6671.00
39_L58_V0.6661.00
330_I333_G0.6661.00
299_T302_I0.6661.00
8_F327_I0.6621.00
287_D296_Y0.6601.00
23_L27_V0.6601.00
118_V121_L0.6581.00
311_L314_T0.6541.00
102_L320_A0.6461.00
54_E58_V0.6441.00
108_L213_V0.6431.00
119_I217_A0.6391.00
119_I123_T0.6381.00
138_L141_G0.6371.00
160_L164_Y0.6361.00
117_V224_V0.6351.00
29_I33_I0.6351.00
224_V270_L0.6351.00
16_A19_T0.6321.00
102_L106_L0.6321.00
110_I275_F0.6311.00
270_L274_L0.6281.00
111_P114_I0.6271.00
136_D140_R0.6271.00
35_A38_P0.6211.00
282_A285_I0.6201.00
47_G50_A0.6191.00
15_N18_I0.6171.00
242_K246_M0.6151.00
103_P106_L0.6141.00
333_G340_R0.6121.00
219_V222_G0.6101.00
66_Q71_Q0.6091.00
50_A54_E0.6081.00
75_Y79_V0.6081.00
20_L323_I0.6051.00
241_A245_L0.6051.00
151_P218_L0.6031.00
25_I69_Y0.6021.00
163_A211_L0.6021.00
252_R255_V0.6011.00
211_L214_I0.6011.00
216_I285_I0.5971.00
117_V121_L0.5941.00
151_P154_I0.5931.00
45_Y48_P0.5921.00
76_I80_L0.5921.00
77_I82_G0.5911.00
105_T286_E0.5881.00
97_L101_Y0.5881.00
44_L47_G0.5871.00
250_S254_V0.5861.00
272_A324_A0.5851.00
292_H296_Y0.5851.00
223_I270_L0.5831.00
17_F330_I0.5821.00
111_P210_V0.5821.00
283_V287_D0.5761.00
232_M236_M0.5761.00
287_D299_T0.5751.00
308_T312_G0.5741.00
127_A140_R0.5741.00
211_L215_A0.5721.00
227_I231_S0.5691.00
264_S267_L0.5681.00
83_N95_I0.5681.00
249_L252_R0.5661.00
265_I339_V0.5661.00
224_V228_A0.5621.00
217_A220_S0.5611.00
223_I274_L0.5601.00
146_T218_L0.5591.00
215_A285_I0.5591.00
8_F326_L0.5571.00
222_G225_T0.5561.00
17_F21_I0.5551.00
230_A233_L0.5551.00
310_I314_T0.5541.00
284_V288_I0.5531.00
129_S236_M0.5531.00
109_V282_A0.5491.00
111_P115_L0.5491.00
296_Y299_T0.5471.00
231_S266_P0.5471.00
67_P71_Q0.5461.00
321_I325_N0.5451.00
39_L62_Y0.5441.00
114_I118_V0.5441.00
105_T282_A0.5401.00
287_D300_Q0.5391.00
238_S242_K0.5391.00
31_I310_I0.5381.00
143_Y146_T0.5361.00
298_I317_V0.5351.00
130_N255_V0.5341.00
24_I76_I0.5341.00
59_A65_D0.5321.00
87_D90_Y0.5301.00
312_G315_I0.5271.00
268_V331_L0.5241.00
170_P208_H0.5241.00
14_I17_F0.5231.00
283_V299_T0.5201.00
107_E213_V0.5191.00
11_R14_I0.5191.00
151_P219_V0.5181.00
107_E291_Y0.5171.00
128_A136_D0.5171.00
133_K136_D0.5171.00
228_A260_L0.5161.00
220_S274_L0.5151.00
256_Y261_R0.5151.00
109_V113_T0.5151.00
115_L214_I0.5141.00
101_Y296_Y0.5141.00
61_Q91_K0.5121.00
90_Y309_S0.5101.00
16_A20_L0.5081.00
113_T117_V0.5071.00
328_A332_Y0.5061.00
216_I282_A0.5061.00
218_L221_F0.5051.00
170_P207_H0.5041.00
284_V287_D0.5041.00
9_I12_R0.5031.00
153_L156_V0.5011.00
141_G145_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.7988 99.9 0.678 Contact Map
3tuiA 2 0.6093 99.9 0.68 Contact Map
3d31C 2 0.7201 99.9 0.701 Contact Map
3rlfF 1 0.8076 99.8 0.706 Contact Map
4ymuD 2 0.6122 99.8 0.713 Contact Map
2onkC 2 0.7289 99.8 0.714 Contact Map
4tquN 1 0.7551 99.8 0.722 Contact Map
3rlfG 1 0.8047 99.7 0.75 Contact Map
2yevC 1 0.0875 12.2 0.962 Contact Map
1v54I 1 0.2012 7.7 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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