Q97VK4 - SULSO - GREMLIN Contacts

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Q97VK4 - Uncharacterized protein

UniProt:	Q97VK4	Sequences: MEKNLRRRIQKIKGGSYIITLPPEWVRRNNLDAKSEVFVIEKNGELLIKPIRDYITRKIIDLDLIDLETTKYLITVYYMQGISEIEIKSKSVISAPIKDELKNLQLYLPGLTIESESFNYITFKVQDDVNTNVVERMKTFSSKLLVLLKDLEKIIENPSKEMAIDLKNRAEELNKLYNSVIREIALVSQKEEEFVVKGLPTRDLILYAIAMRDMGRMLSHIKTASLAITECGNTSNDKELNSIIKIIVNMFEKSREVFFDENIDHVRSIRESMKEINKIVYGSKIECRELARELARIASYCVALMDDGVHKSVKI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	315 (306)
Sequences:	378 (292)
Seq/√Len:	16.7

HALSA - Q9HRB9 Q9HS09
SULSO - Q97VK4 Q7LXS0 Q980F5 Q97ZI3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_I	31_L	4.222	1.00
37_V	48_I	4.108	1.00
216_R	220_H	4.079	1.00
215_G	219_S	4.070	1.00
16_S	20_T	3.735	1.00
150_D	169_R	3.699	1.00
170_A	215_G	3.510	1.00
147_L	170_A	3.476	1.00
219_S	306_D	3.213	0.99
220_H	300_Y	3.153	0.99
174_N	219_S	3.103	0.99
216_R	300_Y	3.063	0.99
170_A	219_S	3.030	0.99
148_L	297_I	2.948	0.98
147_L	215_G	2.894	0.98
215_G	306_D	2.847	0.98
151_L	221_I	2.800	0.98
174_N	215_G	2.786	0.98
22_P	25_W	2.528	0.96
220_H	296_R	2.470	0.95
99_D	139_T	2.363	0.94
140_F	173_L	2.331	0.93
129_V	179_S	2.266	0.92
87_I	113_I	2.239	0.92
5_L	8_R	2.171	0.90
26_V	31_L	2.134	0.90
13_K	72_Y	2.117	0.89
147_L	219_S	2.099	0.89
11_K	14_G	2.071	0.88
210_A	258_F	2.056	0.88
10_Q	20_T	2.038	0.87
39_V	46_L	1.981	0.86
172_E	175_K	1.937	0.84
296_R	300_Y	1.916	0.84
151_L	163_A	1.910	0.83
150_D	216_R	1.889	0.83
12_I	15_G	1.857	0.82
216_R	296_R	1.816	0.80
170_A	174_N	1.793	0.79
7_R	22_P	1.788	0.79
185_A	206_L	1.693	0.75
257_V	266_V	1.686	0.75
214_M	251_F	1.671	0.74
30_N	121_I	1.652	0.73
10_Q	16_S	1.651	0.73
174_N	303_A	1.645	0.73
194_F	197_K	1.638	0.73
174_N	306_D	1.637	0.72
187_V	197_K	1.631	0.72
7_R	25_W	1.610	0.71
32_D	35_S	1.610	0.71
17_Y	24_E	1.595	0.70
87_I	133_V	1.590	0.70
293_E	300_Y	1.586	0.70
217_M	297_I	1.581	0.70
152_E	161_E	1.579	0.70
154_I	163_A	1.556	0.69
296_R	303_A	1.539	0.68
16_S	26_V	1.537	0.68
235_S	252_E	1.528	0.67
16_S	124_K	1.523	0.67
12_I	18_I	1.513	0.66
47_L	87_I	1.512	0.66
8_R	17_Y	1.506	0.66
219_S	303_A	1.504	0.66
170_A	303_A	1.491	0.65
74_I	104_L	1.490	0.65
10_Q	15_G	1.480	0.64
48_I	87_I	1.475	0.64
220_H	293_E	1.472	0.64
135_E	139_T	1.463	0.64
35_S	143_K	1.438	0.62
179_S	183_E	1.428	0.62
127_D	212_R	1.411	0.61
12_I	17_Y	1.405	0.60
216_R	306_D	1.398	0.60
251_F	301_C	1.396	0.60
12_I	216_R	1.381	0.59
13_K	34_K	1.362	0.58
78_Y	110_G	1.337	0.56
133_V	190_K	1.335	0.56
21_L	25_W	1.334	0.56
199_L	207_Y	1.333	0.56
147_L	174_N	1.304	0.54
15_G	206_L	1.303	0.54
14_G	17_Y	1.299	0.54
140_F	218_L	1.285	0.53
12_I	306_D	1.273	0.53
43_N	304_L	1.270	0.52
70_T	176_L	1.266	0.52
15_G	66_D	1.259	0.52
12_I	300_Y	1.249	0.51
144_L	221_I	1.227	0.50
7_R	10_Q	1.226	0.50
266_V	270_R	1.224	0.50
223_T	292_R	1.221	0.50
62_L	66_D	1.216	0.49
62_L	157_N	1.212	0.49
205_I	208_A	1.210	0.49
76_V	174_N	1.201	0.48
104_L	212_R	1.201	0.48
179_S	194_F	1.194	0.48
48_I	258_F	1.187	0.48
13_K	23_P	1.167	0.46
75_T	183_E	1.157	0.46
300_Y	306_D	1.154	0.46
7_R	13_K	1.144	0.45
17_Y	254_S	1.138	0.45
163_A	166_L	1.134	0.44
83_S	288_R	1.133	0.44
168_N	190_K	1.133	0.44
170_A	306_D	1.128	0.44
13_K	25_W	1.128	0.44
152_E	244_I	1.125	0.44
115_S	169_R	1.125	0.44
18_I	216_R	1.118	0.44
150_D	162_M	1.115	0.43
87_I	210_A	1.109	0.43
83_S	301_C	1.108	0.43
173_L	255_R	1.105	0.43
11_K	16_S	1.103	0.43
39_V	132_N	1.096	0.42
57_R	84_E	1.095	0.42
150_D	220_H	1.093	0.42
16_S	45_E	1.086	0.42
7_R	16_S	1.083	0.41
59_I	88_K	1.080	0.41
76_V	215_G	1.078	0.41
170_A	296_R	1.075	0.41
144_L	151_L	1.060	0.40
57_R	86_E	1.051	0.40
12_I	23_P	1.044	0.39
155_I	228_I	1.039	0.39
214_M	268_S	1.038	0.39
306_D	310_H	1.038	0.39
167_K	170_A	1.035	0.39
181_I	208_A	1.034	0.39
76_V	219_S	1.033	0.39
220_H	306_D	1.020	0.38
10_Q	13_K	1.019	0.38
21_L	45_E	1.018	0.38
162_M	225_S	1.010	0.37
253_K	272_S	1.008	0.37
14_G	169_R	1.008	0.37
12_I	116_E	1.002	0.37
166_L	218_L	0.996	0.37
136_R	180_V	0.990	0.36
122_T	198_G	0.989	0.36
121_I	171_E	0.985	0.36
21_L	310_H	0.981	0.36
126_Q	179_S	0.970	0.35
294_L	298_A	0.968	0.35
249_N	275_E	0.967	0.35
137_M	199_L	0.966	0.35
116_E	306_D	0.966	0.35
108_L	178_N	0.964	0.35
95_A	260_D	0.962	0.35
21_L	120_Y	0.957	0.34
14_G	20_T	0.954	0.34
113_I	261_E	0.947	0.34
88_K	175_K	0.945	0.34
101_L	282_G	0.934	0.33
301_C	305_M	0.933	0.33
18_I	228_I	0.931	0.33
183_E	186_L	0.928	0.33
7_R	19_I	0.928	0.33
166_L	247_I	0.927	0.33
173_L	303_A	0.926	0.33
32_D	37_V	0.924	0.33
55_I	282_G	0.923	0.33
170_A	216_R	0.920	0.33
112_T	174_N	0.919	0.32
172_E	239_E	0.914	0.32
149_K	172_E	0.906	0.32
121_I	287_C	0.901	0.32
212_R	300_Y	0.901	0.32
105_Q	212_R	0.895	0.31
140_F	215_G	0.895	0.31
130_N	153_K	0.894	0.31
126_Q	293_E	0.891	0.31
112_T	172_E	0.888	0.31
293_E	309_V	0.880	0.30
254_S	301_C	0.879	0.30
106_L	290_L	0.873	0.30
29_N	127_D	0.872	0.30
135_E	302_V	0.870	0.30
19_I	22_P	0.870	0.30
63_D	211_M	0.866	0.30
162_M	166_L	0.862	0.30
55_I	153_K	0.862	0.30
94_S	282_G	0.860	0.29
165_D	169_R	0.854	0.29
89_S	93_I	0.850	0.29
84_E	124_K	0.849	0.29
111_L	175_K	0.849	0.29
171_E	179_S	0.847	0.29
33_A	305_M	0.845	0.29
16_S	22_P	0.841	0.29
20_T	175_K	0.841	0.29
87_I	156_E	0.839	0.28
156_E	238_K	0.837	0.28
15_G	49_K	0.823	0.28
104_L	211_M	0.821	0.28
13_K	16_S	0.821	0.28
86_E	120_Y	0.816	0.27
108_L	208_A	0.815	0.27
79_M	303_A	0.815	0.27
171_E	174_N	0.811	0.27
257_V	308_G	0.811	0.27
98_K	150_D	0.810	0.27
152_E	241_N	0.809	0.27
37_V	104_L	0.807	0.27
181_I	205_I	0.806	0.27
79_M	178_N	0.805	0.27
109_P	127_D	0.805	0.27
68_E	89_S	0.804	0.27
174_N	220_H	0.802	0.27
21_L	114_E	0.802	0.27
50_P	136_R	0.799	0.27
43_N	267_R	0.799	0.27
100_E	154_I	0.797	0.26
208_A	307_D	0.794	0.26
72_Y	175_K	0.794	0.26
276_I	298_A	0.792	0.26
161_E	173_L	0.790	0.26
198_G	294_L	0.789	0.26
131_T	224_A	0.787	0.26
11_K	206_L	0.786	0.26
174_N	216_R	0.782	0.26
17_Y	188_S	0.780	0.26
9_I	17_Y	0.778	0.26
105_Q	213_D	0.778	0.26
131_T	175_K	0.771	0.25
17_Y	26_V	0.770	0.25
174_N	293_E	0.770	0.25
34_K	108_L	0.769	0.25
230_E	271_E	0.767	0.25
33_A	76_V	0.767	0.25
173_L	218_L	0.766	0.25
9_I	147_L	0.765	0.25
19_I	186_L	0.763	0.25
51_I	137_M	0.759	0.25
46_L	302_V	0.755	0.25
153_K	162_M	0.755	0.25
246_I	264_D	0.753	0.24
139_T	142_S	0.753	0.24
48_I	282_G	0.748	0.24
300_Y	310_H	0.747	0.24
262_N	265_H	0.745	0.24
34_K	104_L	0.742	0.24
14_G	18_I	0.742	0.24
77_Y	102_K	0.741	0.24
77_Y	127_D	0.741	0.24
270_R	273_M	0.740	0.24
10_Q	14_G	0.738	0.24
9_I	176_L	0.737	0.24
35_S	310_H	0.736	0.24
213_D	303_A	0.733	0.24
44_G	232_G	0.727	0.23
10_Q	22_P	0.725	0.23
240_L	294_L	0.724	0.23
47_L	250_M	0.724	0.23
9_I	29_N	0.722	0.23
89_S	116_E	0.716	0.23
186_L	204_L	0.713	0.23
175_K	211_M	0.711	0.23
16_S	36_E	0.707	0.23
149_K	268_S	0.701	0.22
16_S	25_W	0.701	0.22
217_M	251_F	0.701	0.22
292_R	306_D	0.700	0.22
295_A	299_S	0.700	0.22
109_P	178_N	0.700	0.22
31_L	143_K	0.698	0.22
8_R	15_G	0.697	0.22
144_L	247_I	0.696	0.22
102_K	144_L	0.693	0.22
289_E	303_A	0.691	0.22
21_L	46_L	0.691	0.22
16_S	182_R	0.689	0.22
126_Q	175_K	0.689	0.22
95_A	290_L	0.688	0.22
94_S	240_L	0.687	0.22
291_A	298_A	0.687	0.22
74_I	157_N	0.686	0.22
126_Q	131_T	0.684	0.22
115_S	240_L	0.684	0.22
89_S	252_E	0.683	0.22
125_V	181_I	0.683	0.22
33_A	146_V	0.682	0.22
245_K	262_N	0.680	0.21
33_A	213_D	0.680	0.21
39_V	88_K	0.677	0.21
30_N	262_N	0.677	0.21
239_E	281_Y	0.676	0.21
13_K	22_P	0.675	0.21
87_I	261_E	0.675	0.21
104_L	108_L	0.674	0.21
170_A	206_L	0.673	0.21
23_P	126_Q	0.673	0.21
216_R	293_E	0.672	0.21
102_K	121_I	0.669	0.21
220_H	303_A	0.669	0.21
243_I	249_N	0.667	0.21
19_I	25_W	0.667	0.21
243_I	291_A	0.666	0.21
108_L	182_R	0.665	0.21
159_S	173_L	0.665	0.21
5_L	262_N	0.665	0.21
88_K	156_E	0.664	0.21
205_I	212_R	0.663	0.21
44_G	187_V	0.660	0.21
101_L	262_N	0.659	0.21
188_S	201_T	0.659	0.21
150_D	296_R	0.659	0.21
18_I	297_I	0.656	0.20
21_L	31_L	0.655	0.20
147_L	303_A	0.654	0.20
31_L	290_L	0.651	0.20
105_Q	176_L	0.651	0.20
118_F	124_K	0.651	0.20
146_V	235_S	0.650	0.20
16_S	125_V	0.646	0.20
93_I	291_A	0.645	0.20
54_Y	120_Y	0.643	0.20
143_K	292_R	0.643	0.20
123_F	164_I	0.643	0.20
44_G	255_R	0.642	0.20
149_K	252_E	0.635	0.20
153_K	157_N	0.634	0.20
147_L	218_L	0.633	0.20
133_V	137_M	0.631	0.20
210_A	253_K	0.628	0.19
266_V	305_M	0.625	0.19
116_E	293_E	0.625	0.19
29_N	44_G	0.625	0.19
150_D	165_D	0.624	0.19
141_S	303_A	0.624	0.19
30_N	234_T	0.623	0.19
221_I	225_S	0.623	0.19
122_T	153_K	0.623	0.19
206_L	307_D	0.623	0.19
63_D	260_D	0.623	0.19
293_E	306_D	0.623	0.19
298_A	305_M	0.621	0.19
39_V	178_N	0.620	0.19
171_E	224_A	0.618	0.19
269_I	278_K	0.618	0.19
6_R	46_L	0.617	0.19
19_I	32_D	0.616	0.19
11_K	214_M	0.615	0.19
112_T	292_R	0.615	0.19
150_D	300_Y	0.614	0.19
135_E	142_S	0.614	0.19
13_K	219_S	0.613	0.19
174_N	296_R	0.613	0.19
267_R	309_V	0.611	0.19
183_E	310_H	0.611	0.19
62_L	238_K	0.610	0.19
98_K	173_L	0.609	0.19
9_I	306_D	0.608	0.19
293_E	303_A	0.608	0.19
277_N	281_Y	0.606	0.19
46_L	78_Y	0.604	0.19
12_I	132_N	0.601	0.18
144_L	302_V	0.600	0.18
154_I	159_S	0.600	0.18
229_T	274_K	0.599	0.18
26_V	143_K	0.598	0.18
119_N	243_I	0.598	0.18
172_E	297_I	0.593	0.18
77_Y	129_V	0.592	0.18
166_L	173_L	0.591	0.18
215_G	218_L	0.590	0.18
35_S	210_A	0.588	0.18
218_L	254_S	0.588	0.18
85_I	112_T	0.582	0.18
264_D	279_I	0.581	0.18
212_R	216_R	0.580	0.18
46_L	170_A	0.580	0.18
38_F	297_I	0.576	0.18
59_I	122_T	0.575	0.18
262_N	275_E	0.574	0.18
143_K	246_I	0.573	0.17
233_N	283_S	0.571	0.17
275_E	279_I	0.569	0.17
170_A	310_H	0.569	0.17
53_D	275_E	0.568	0.17
39_V	48_I	0.566	0.17
60_I	68_E	0.565	0.17
210_A	302_V	0.564	0.17
32_D	175_K	0.563	0.17
105_Q	113_I	0.561	0.17
112_T	139_T	0.560	0.17
151_L	297_I	0.560	0.17
215_G	303_A	0.560	0.17
72_Y	219_S	0.559	0.17
179_S	310_H	0.558	0.17
76_V	194_F	0.557	0.17
12_I	293_E	0.557	0.17
126_Q	170_A	0.556	0.17
154_I	257_V	0.555	0.17
221_I	301_C	0.554	0.17
60_I	204_L	0.554	0.17
289_E	292_R	0.553	0.17
184_I	303_A	0.553	0.17
126_Q	224_A	0.551	0.17
187_V	258_F	0.551	0.17
132_N	195_V	0.548	0.17
44_G	277_N	0.548	0.17
166_L	170_A	0.546	0.17
16_S	221_I	0.545	0.17
9_I	46_L	0.545	0.17
41_E	184_I	0.545	0.17
210_A	266_V	0.545	0.17
149_K	161_E	0.544	0.17
87_I	153_K	0.544	0.17
35_S	303_A	0.544	0.17
53_D	268_S	0.542	0.16
43_N	230_E	0.542	0.16
76_V	218_L	0.542	0.16
13_K	174_N	0.541	0.16
170_A	173_L	0.537	0.16
75_T	310_H	0.533	0.16
12_I	258_F	0.532	0.16
238_K	275_E	0.531	0.16
186_L	190_K	0.530	0.16
19_I	106_L	0.529	0.16
202_R	206_L	0.529	0.16
238_K	245_K	0.527	0.16
21_L	162_M	0.526	0.16
12_I	224_A	0.526	0.16
138_K	144_L	0.522	0.16
15_G	175_K	0.520	0.16
181_I	190_K	0.518	0.16
102_K	131_T	0.516	0.16
114_E	208_A	0.516	0.16
276_I	287_C	0.514	0.16
130_N	137_M	0.513	0.16
215_G	220_H	0.511	0.15
186_L	193_E	0.511	0.15
14_G	123_F	0.511	0.15
131_T	299_S	0.510	0.15
129_V	193_E	0.509	0.15
221_I	293_E	0.509	0.15
142_S	175_K	0.506	0.15
176_L	276_I	0.506	0.15
95_A	133_V	0.506	0.15
200_P	265_H	0.506	0.15
83_S	244_I	0.504	0.15
113_I	298_A	0.504	0.15
117_S	120_Y	0.503	0.15
21_L	26_V	0.503	0.15
108_L	132_N	0.503	0.15
34_K	72_Y	0.502	0.15
94_S	197_K	0.502	0.15
79_M	181_I	0.502	0.15
140_F	306_D	0.501	0.15
37_V	77_Y	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1sumB	2	0.6032	99.8	0.772	Contact Map
1xwmA	2	0.5968	99.8	0.775	Contact Map
2i0mA	2	0.5841	99.8	0.778	Contact Map
1t72A	5	0.6127	99.8	0.78	Contact Map
4q25A	2	0.5937	99.7	0.785	Contact Map
2oltA	5	0.5683	99.5	0.825	Contact Map
2mrnA	2	0.1683	98.6	0.877	Contact Map
3o27A	2	0.1714	98.2	0.891	Contact Map
1mvfD	1	0.1397	98.2	0.893	Contact Map
3l39A	3	0.5778	98	0.896	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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