GREMLIN Database
Q97VK4 - Uncharacterized protein
UniProt: Q97VK4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (306)
Sequences: 378 (292)
Seq/√Len: 16.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_I31_L4.2221.00
37_V48_I4.1081.00
216_R220_H4.0791.00
215_G219_S4.0701.00
16_S20_T3.7351.00
150_D169_R3.6991.00
170_A215_G3.5101.00
147_L170_A3.4761.00
219_S306_D3.2130.99
220_H300_Y3.1530.99
174_N219_S3.1030.99
216_R300_Y3.0630.99
170_A219_S3.0300.99
148_L297_I2.9480.98
147_L215_G2.8940.98
215_G306_D2.8470.98
151_L221_I2.8000.98
174_N215_G2.7860.98
22_P25_W2.5280.96
220_H296_R2.4700.95
99_D139_T2.3630.94
140_F173_L2.3310.93
129_V179_S2.2660.92
87_I113_I2.2390.92
5_L8_R2.1710.90
26_V31_L2.1340.90
13_K72_Y2.1170.89
147_L219_S2.0990.89
11_K14_G2.0710.88
210_A258_F2.0560.88
10_Q20_T2.0380.87
39_V46_L1.9810.86
172_E175_K1.9370.84
296_R300_Y1.9160.84
151_L163_A1.9100.83
150_D216_R1.8890.83
12_I15_G1.8570.82
216_R296_R1.8160.80
170_A174_N1.7930.79
7_R22_P1.7880.79
185_A206_L1.6930.75
257_V266_V1.6860.75
214_M251_F1.6710.74
30_N121_I1.6520.73
10_Q16_S1.6510.73
174_N303_A1.6450.73
194_F197_K1.6380.73
174_N306_D1.6370.72
187_V197_K1.6310.72
7_R25_W1.6100.71
32_D35_S1.6100.71
17_Y24_E1.5950.70
87_I133_V1.5900.70
293_E300_Y1.5860.70
217_M297_I1.5810.70
152_E161_E1.5790.70
154_I163_A1.5560.69
296_R303_A1.5390.68
16_S26_V1.5370.68
235_S252_E1.5280.67
16_S124_K1.5230.67
12_I18_I1.5130.66
47_L87_I1.5120.66
8_R17_Y1.5060.66
219_S303_A1.5040.66
170_A303_A1.4910.65
74_I104_L1.4900.65
10_Q15_G1.4800.64
48_I87_I1.4750.64
220_H293_E1.4720.64
135_E139_T1.4630.64
35_S143_K1.4380.62
179_S183_E1.4280.62
127_D212_R1.4110.61
12_I17_Y1.4050.60
216_R306_D1.3980.60
251_F301_C1.3960.60
12_I216_R1.3810.59
13_K34_K1.3620.58
78_Y110_G1.3370.56
133_V190_K1.3350.56
21_L25_W1.3340.56
199_L207_Y1.3330.56
147_L174_N1.3040.54
15_G206_L1.3030.54
14_G17_Y1.2990.54
140_F218_L1.2850.53
12_I306_D1.2730.53
43_N304_L1.2700.52
70_T176_L1.2660.52
15_G66_D1.2590.52
12_I300_Y1.2490.51
144_L221_I1.2270.50
7_R10_Q1.2260.50
266_V270_R1.2240.50
223_T292_R1.2210.50
62_L66_D1.2160.49
62_L157_N1.2120.49
205_I208_A1.2100.49
76_V174_N1.2010.48
104_L212_R1.2010.48
179_S194_F1.1940.48
48_I258_F1.1870.48
13_K23_P1.1670.46
75_T183_E1.1570.46
300_Y306_D1.1540.46
7_R13_K1.1440.45
17_Y254_S1.1380.45
163_A166_L1.1340.44
83_S288_R1.1330.44
168_N190_K1.1330.44
170_A306_D1.1280.44
13_K25_W1.1280.44
152_E244_I1.1250.44
115_S169_R1.1250.44
18_I216_R1.1180.44
150_D162_M1.1150.43
87_I210_A1.1090.43
83_S301_C1.1080.43
173_L255_R1.1050.43
11_K16_S1.1030.43
39_V132_N1.0960.42
57_R84_E1.0950.42
150_D220_H1.0930.42
16_S45_E1.0860.42
7_R16_S1.0830.41
59_I88_K1.0800.41
76_V215_G1.0780.41
170_A296_R1.0750.41
144_L151_L1.0600.40
57_R86_E1.0510.40
12_I23_P1.0440.39
155_I228_I1.0390.39
214_M268_S1.0380.39
306_D310_H1.0380.39
167_K170_A1.0350.39
181_I208_A1.0340.39
76_V219_S1.0330.39
220_H306_D1.0200.38
10_Q13_K1.0190.38
21_L45_E1.0180.38
162_M225_S1.0100.37
253_K272_S1.0080.37
14_G169_R1.0080.37
12_I116_E1.0020.37
166_L218_L0.9960.37
136_R180_V0.9900.36
122_T198_G0.9890.36
121_I171_E0.9850.36
21_L310_H0.9810.36
126_Q179_S0.9700.35
294_L298_A0.9680.35
249_N275_E0.9670.35
137_M199_L0.9660.35
116_E306_D0.9660.35
108_L178_N0.9640.35
95_A260_D0.9620.35
21_L120_Y0.9570.34
14_G20_T0.9540.34
113_I261_E0.9470.34
88_K175_K0.9450.34
101_L282_G0.9340.33
301_C305_M0.9330.33
18_I228_I0.9310.33
183_E186_L0.9280.33
7_R19_I0.9280.33
166_L247_I0.9270.33
173_L303_A0.9260.33
32_D37_V0.9240.33
55_I282_G0.9230.33
170_A216_R0.9200.33
112_T174_N0.9190.32
172_E239_E0.9140.32
149_K172_E0.9060.32
121_I287_C0.9010.32
212_R300_Y0.9010.32
105_Q212_R0.8950.31
140_F215_G0.8950.31
130_N153_K0.8940.31
126_Q293_E0.8910.31
112_T172_E0.8880.31
293_E309_V0.8800.30
254_S301_C0.8790.30
106_L290_L0.8730.30
29_N127_D0.8720.30
135_E302_V0.8700.30
19_I22_P0.8700.30
63_D211_M0.8660.30
162_M166_L0.8620.30
55_I153_K0.8620.30
94_S282_G0.8600.29
165_D169_R0.8540.29
89_S93_I0.8500.29
84_E124_K0.8490.29
111_L175_K0.8490.29
171_E179_S0.8470.29
33_A305_M0.8450.29
16_S22_P0.8410.29
20_T175_K0.8410.29
87_I156_E0.8390.28
156_E238_K0.8370.28
15_G49_K0.8230.28
104_L211_M0.8210.28
13_K16_S0.8210.28
86_E120_Y0.8160.27
108_L208_A0.8150.27
79_M303_A0.8150.27
171_E174_N0.8110.27
257_V308_G0.8110.27
98_K150_D0.8100.27
152_E241_N0.8090.27
37_V104_L0.8070.27
181_I205_I0.8060.27
79_M178_N0.8050.27
109_P127_D0.8050.27
68_E89_S0.8040.27
174_N220_H0.8020.27
21_L114_E0.8020.27
50_P136_R0.7990.27
43_N267_R0.7990.27
100_E154_I0.7970.26
208_A307_D0.7940.26
72_Y175_K0.7940.26
276_I298_A0.7920.26
161_E173_L0.7900.26
198_G294_L0.7890.26
131_T224_A0.7870.26
11_K206_L0.7860.26
174_N216_R0.7820.26
17_Y188_S0.7800.26
9_I17_Y0.7780.26
105_Q213_D0.7780.26
131_T175_K0.7710.25
17_Y26_V0.7700.25
174_N293_E0.7700.25
34_K108_L0.7690.25
230_E271_E0.7670.25
33_A76_V0.7670.25
173_L218_L0.7660.25
9_I147_L0.7650.25
19_I186_L0.7630.25
51_I137_M0.7590.25
46_L302_V0.7550.25
153_K162_M0.7550.25
246_I264_D0.7530.24
139_T142_S0.7530.24
48_I282_G0.7480.24
300_Y310_H0.7470.24
262_N265_H0.7450.24
34_K104_L0.7420.24
14_G18_I0.7420.24
77_Y102_K0.7410.24
77_Y127_D0.7410.24
270_R273_M0.7400.24
10_Q14_G0.7380.24
9_I176_L0.7370.24
35_S310_H0.7360.24
213_D303_A0.7330.24
44_G232_G0.7270.23
10_Q22_P0.7250.23
240_L294_L0.7240.23
47_L250_M0.7240.23
9_I29_N0.7220.23
89_S116_E0.7160.23
186_L204_L0.7130.23
175_K211_M0.7110.23
16_S36_E0.7070.23
149_K268_S0.7010.22
16_S25_W0.7010.22
217_M251_F0.7010.22
292_R306_D0.7000.22
295_A299_S0.7000.22
109_P178_N0.7000.22
31_L143_K0.6980.22
8_R15_G0.6970.22
144_L247_I0.6960.22
102_K144_L0.6930.22
289_E303_A0.6910.22
21_L46_L0.6910.22
16_S182_R0.6890.22
126_Q175_K0.6890.22
95_A290_L0.6880.22
94_S240_L0.6870.22
291_A298_A0.6870.22
74_I157_N0.6860.22
126_Q131_T0.6840.22
115_S240_L0.6840.22
89_S252_E0.6830.22
125_V181_I0.6830.22
33_A146_V0.6820.22
245_K262_N0.6800.21
33_A213_D0.6800.21
39_V88_K0.6770.21
30_N262_N0.6770.21
239_E281_Y0.6760.21
13_K22_P0.6750.21
87_I261_E0.6750.21
104_L108_L0.6740.21
170_A206_L0.6730.21
23_P126_Q0.6730.21
216_R293_E0.6720.21
102_K121_I0.6690.21
220_H303_A0.6690.21
243_I249_N0.6670.21
19_I25_W0.6670.21
243_I291_A0.6660.21
108_L182_R0.6650.21
159_S173_L0.6650.21
5_L262_N0.6650.21
88_K156_E0.6640.21
205_I212_R0.6630.21
44_G187_V0.6600.21
101_L262_N0.6590.21
188_S201_T0.6590.21
150_D296_R0.6590.21
18_I297_I0.6560.20
21_L31_L0.6550.20
147_L303_A0.6540.20
31_L290_L0.6510.20
105_Q176_L0.6510.20
118_F124_K0.6510.20
146_V235_S0.6500.20
16_S125_V0.6460.20
93_I291_A0.6450.20
54_Y120_Y0.6430.20
143_K292_R0.6430.20
123_F164_I0.6430.20
44_G255_R0.6420.20
149_K252_E0.6350.20
153_K157_N0.6340.20
147_L218_L0.6330.20
133_V137_M0.6310.20
210_A253_K0.6280.19
266_V305_M0.6250.19
116_E293_E0.6250.19
29_N44_G0.6250.19
150_D165_D0.6240.19
141_S303_A0.6240.19
30_N234_T0.6230.19
221_I225_S0.6230.19
122_T153_K0.6230.19
206_L307_D0.6230.19
63_D260_D0.6230.19
293_E306_D0.6230.19
298_A305_M0.6210.19
39_V178_N0.6200.19
171_E224_A0.6180.19
269_I278_K0.6180.19
6_R46_L0.6170.19
19_I32_D0.6160.19
11_K214_M0.6150.19
112_T292_R0.6150.19
150_D300_Y0.6140.19
135_E142_S0.6140.19
13_K219_S0.6130.19
174_N296_R0.6130.19
267_R309_V0.6110.19
183_E310_H0.6110.19
62_L238_K0.6100.19
98_K173_L0.6090.19
9_I306_D0.6080.19
293_E303_A0.6080.19
277_N281_Y0.6060.19
46_L78_Y0.6040.19
12_I132_N0.6010.18
144_L302_V0.6000.18
154_I159_S0.6000.18
229_T274_K0.5990.18
26_V143_K0.5980.18
119_N243_I0.5980.18
172_E297_I0.5930.18
77_Y129_V0.5920.18
166_L173_L0.5910.18
215_G218_L0.5900.18
35_S210_A0.5880.18
218_L254_S0.5880.18
85_I112_T0.5820.18
264_D279_I0.5810.18
212_R216_R0.5800.18
46_L170_A0.5800.18
38_F297_I0.5760.18
59_I122_T0.5750.18
262_N275_E0.5740.18
143_K246_I0.5730.17
233_N283_S0.5710.17
275_E279_I0.5690.17
170_A310_H0.5690.17
53_D275_E0.5680.17
39_V48_I0.5660.17
60_I68_E0.5650.17
210_A302_V0.5640.17
32_D175_K0.5630.17
105_Q113_I0.5610.17
112_T139_T0.5600.17
151_L297_I0.5600.17
215_G303_A0.5600.17
72_Y219_S0.5590.17
179_S310_H0.5580.17
76_V194_F0.5570.17
12_I293_E0.5570.17
126_Q170_A0.5560.17
154_I257_V0.5550.17
221_I301_C0.5540.17
60_I204_L0.5540.17
289_E292_R0.5530.17
184_I303_A0.5530.17
126_Q224_A0.5510.17
187_V258_F0.5510.17
132_N195_V0.5480.17
44_G277_N0.5480.17
166_L170_A0.5460.17
16_S221_I0.5450.17
9_I46_L0.5450.17
41_E184_I0.5450.17
210_A266_V0.5450.17
149_K161_E0.5440.17
87_I153_K0.5440.17
35_S303_A0.5440.17
53_D268_S0.5420.16
43_N230_E0.5420.16
76_V218_L0.5420.16
13_K174_N0.5410.16
170_A173_L0.5370.16
75_T310_H0.5330.16
12_I258_F0.5320.16
238_K275_E0.5310.16
186_L190_K0.5300.16
19_I106_L0.5290.16
202_R206_L0.5290.16
238_K245_K0.5270.16
21_L162_M0.5260.16
12_I224_A0.5260.16
138_K144_L0.5220.16
15_G175_K0.5200.16
181_I190_K0.5180.16
102_K131_T0.5160.16
114_E208_A0.5160.16
276_I287_C0.5140.16
130_N137_M0.5130.16
215_G220_H0.5110.15
186_L193_E0.5110.15
14_G123_F0.5110.15
131_T299_S0.5100.15
129_V193_E0.5090.15
221_I293_E0.5090.15
142_S175_K0.5060.15
176_L276_I0.5060.15
95_A133_V0.5060.15
200_P265_H0.5060.15
83_S244_I0.5040.15
113_I298_A0.5040.15
117_S120_Y0.5030.15
21_L26_V0.5030.15
108_L132_N0.5030.15
34_K72_Y0.5020.15
94_S197_K0.5020.15
79_M181_I0.5020.15
140_F306_D0.5010.15
37_V77_Y0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sumB 2 0.6032 99.8 0.772 Contact Map
1xwmA 2 0.5968 99.8 0.775 Contact Map
2i0mA 2 0.5841 99.8 0.778 Contact Map
1t72A 5 0.6127 99.8 0.78 Contact Map
4q25A 2 0.5937 99.7 0.785 Contact Map
2oltA 5 0.5683 99.5 0.825 Contact Map
2mrnA 2 0.1683 98.6 0.877 Contact Map
3o27A 2 0.1714 98.2 0.891 Contact Map
1mvfD 1 0.1397 98.2 0.893 Contact Map
3l39A 3 0.5778 98 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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