GREMLIN Database
Q97VK2 - Phenylacetic acid degradation paaI protein homolog (PaaI)
UniProt: Q97VK2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 121 (112)
Sequences: 1990 (1389)
Seq/√Len: 131.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_E25_S3.5321.00
25_S80_K2.9601.00
13_E25_S2.7201.00
65_L94_T2.3841.00
23_R84_E2.2791.00
45_F67_M2.2731.00
26_G43_F2.1151.00
16_E23_R2.0701.00
18_R21_Y2.0511.00
84_E102_K2.0361.00
16_E21_Y2.0181.00
24_V51_A1.8941.00
20_G58_F1.8091.00
48_A99_I1.7861.00
45_F69_I1.7441.00
21_Y84_E1.7391.00
79_E104_E1.7221.00
27_V80_K1.7051.00
15_E23_R1.5791.00
79_E103_N1.5761.00
100_I108_L1.5441.00
103_N107_K1.5221.00
28_V39_A1.5171.00
45_F71_F1.5011.00
21_Y86_F1.4821.00
25_S82_I1.4391.00
51_A83_A1.4381.00
9_F31_D1.4341.00
59_S87_E1.3831.00
56_S116_V1.3801.00
29_A32_F1.3711.00
70_D115_L1.3421.00
23_R82_I1.3401.00
30_K77_E1.3321.00
86_F100_I1.3291.00
39_A75_V1.3231.00
66_H70_D1.3211.00
87_E90_S1.3061.00
26_G47_I1.2671.00
44_I110_A1.2451.00
52_F99_I1.2431.00
73_R107_K1.2391.00
98_R113_T1.2291.00
100_I111_Y1.1930.99
88_E98_R1.1900.99
39_A81_V1.1880.99
59_S90_S1.1720.99
52_F116_V1.1670.99
48_A112_V1.1660.99
75_V109_V1.1410.99
66_H115_L1.1230.99
7_L54_Y1.1100.99
44_I101_V1.1100.99
38_T63_V1.0940.99
35_L53_E1.0670.99
52_F114_A1.0650.99
98_R111_Y1.0590.99
30_K33_L1.0580.99
81_V101_V1.0560.99
84_E106_G1.0220.98
88_E111_Y1.0220.98
20_G55_I1.0190.98
81_V109_V1.0140.98
13_E80_K1.0120.98
102_K106_G0.9940.98
89_S94_T0.9750.98
20_G87_E0.9740.98
12_I24_V0.9720.98
56_S95_S0.9610.97
55_I87_E0.9490.97
86_F98_R0.9460.97
10_L46_A0.9450.97
87_E97_Y0.9330.97
72_R89_S0.9200.97
50_A54_Y0.9190.97
24_V54_Y0.8990.96
42_S46_A0.8950.96
13_E27_V0.8940.96
40_H50_A0.8520.95
52_F64_A0.8470.95
56_S97_Y0.8460.95
9_F43_F0.8290.94
48_A69_I0.8160.94
83_A99_I0.8130.93
7_L50_A0.7920.93
67_M99_I0.7900.93
66_H113_T0.7890.92
64_A67_M0.7830.92
6_F46_A0.7830.92
28_V33_L0.7780.92
65_L115_L0.7740.92
49_D64_A0.7740.92
62_S116_V0.7690.91
48_A101_V0.7670.91
32_F43_F0.7660.91
6_F43_F0.7580.91
5_P30_K0.7520.91
33_L77_E0.7440.90
84_E100_I0.7400.90
64_A71_F0.7340.89
18_R23_R0.7290.89
56_S62_S0.7250.89
73_R91_G0.7240.89
82_I103_N0.7130.88
55_I85_A0.7120.88
5_P8_K0.7040.87
34_N71_F0.6960.87
67_M112_V0.6950.87
60_R90_S0.6940.87
10_L32_F0.6940.87
68_D115_L0.6900.86
69_I110_A0.6790.86
60_R92_K0.6740.85
75_V81_V0.6710.85
80_K104_E0.6680.85
34_N52_F0.6660.84
95_S116_V0.6630.84
96_L113_T0.6620.84
85_A97_Y0.6620.84
15_E80_K0.6600.84
22_A55_I0.6390.82
58_F87_E0.6380.82
96_L111_Y0.6370.82
36_H61_D0.6310.81
9_F29_A0.6240.80
68_D113_T0.6230.80
91_G94_T0.6210.80
99_I112_V0.6200.80
34_N41_G0.6090.79
87_E95_S0.6090.79
64_A114_A0.6060.78
12_I50_A0.6030.78
19_E87_E0.5990.78
70_D96_L0.5970.77
52_F57_N0.5970.77
12_I26_G0.5940.77
37_N77_E0.5930.77
64_A116_V0.5850.76
6_F9_F0.5780.75
66_H96_L0.5740.75
70_D113_T0.5720.74
76_K107_K0.5680.74
55_I97_Y0.5620.73
85_A99_I0.5620.73
96_L115_L0.5580.73
35_L54_Y0.5570.72
56_S113_T0.5560.72
36_H63_V0.5490.71
10_L26_G0.5480.71
72_R91_G0.5470.71
53_E116_V0.5400.70
34_N38_T0.5390.70
103_N106_G0.5390.70
18_R58_F0.5380.70
52_F97_Y0.5360.70
26_G83_A0.5320.69
47_I101_V0.5310.69
91_G115_L0.5300.69
77_E103_N0.5300.69
72_R96_L0.5290.69
48_A83_A0.5190.67
89_S96_L0.5170.67
64_A112_V0.5170.67
99_I114_A0.5110.66
14_L54_Y0.5090.66
35_L62_S0.5070.65
88_E108_L0.5050.65
73_R89_S0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rmmA 2 0.9421 99.9 0.337 Contact Map
1yocA 4 0.9917 99.9 0.345 Contact Map
3f1tA 2 0.9835 99.9 0.349 Contact Map
3e8pA 3 0.9752 99.9 0.349 Contact Map
1t82A 2 0.9669 99.9 0.35 Contact Map
1sh8A 2 0.9752 99.9 0.352 Contact Map
3lmbA 2 0.9752 99.9 0.354 Contact Map
3gekA 3 0.9752 99.9 0.36 Contact Map
3hduA 4 0.9752 99.9 0.361 Contact Map
1vh5A 2 0.9835 99.9 0.362 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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