GREMLIN Database
Q97VK1 - Enoyl CoA hydratase (PaaF-6)
UniProt: Q97VK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (235)
Sequences: 30068 (19604)
Seq/√Len: 1278.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
121_K159_E3.3571.00
116_A171_L3.1201.00
94_A111_T2.9271.00
12_V182_E2.7821.00
40_N89_D2.6371.00
37_K84_E2.6021.00
118_R174_S2.4981.00
21_L55_R2.4611.00
158_G187_K2.4611.00
210_D213_R2.3581.00
164_D167_R2.3461.00
161_T164_D2.3011.00
152_E158_G2.2181.00
119_E175_E2.2041.00
149_R168_W2.1861.00
128_R191_G2.1691.00
12_V51_T2.1301.00
21_L56_A2.0991.00
95_A181_A2.0471.00
6_N11_V2.0421.00
233_E242_R2.0311.00
101_A123_V1.9831.00
9_G46_R1.9831.00
154_A199_G1.9811.00
27_E31_E1.9771.00
152_E172_K1.9711.00
16_S53_E1.9461.00
33_I84_E1.9461.00
14_T53_E1.9251.00
6_N42_N1.9081.00
236_S240_E1.8571.00
118_R163_E1.8491.00
151_Y204_N1.8481.00
118_R175_E1.8321.00
11_V39_I1.8161.00
14_T51_T1.8031.00
38_E42_N1.7621.00
164_D168_W1.7551.00
48_V88_S1.7481.00
112_D200_K1.7061.00
182_E186_N1.6931.00
147_D151_Y1.6891.00
115_F184_M1.6551.00
11_V45_I1.6441.00
30_N77_T1.6201.00
163_E167_R1.6181.00
95_A179_Y1.6101.00
116_A122_F1.5861.00
39_I48_V1.5861.00
180_D183_E1.5841.00
7_K182_E1.5781.00
40_N84_E1.5701.00
114_K148_Q1.5591.00
47_T185_A1.5361.00
108_S114_K1.5331.00
114_K144_L1.5311.00
51_T97_N1.5061.00
151_Y203_A1.5021.00
8_D186_N1.4891.00
83_R212_E1.4881.00
151_Y155_V1.4881.00
13_V35_K1.4751.00
83_R87_F1.4451.00
97_N119_E1.4331.00
96_I108_S1.4311.00
85_I92_Y1.4221.00
117_K175_E1.4171.00
86_R140_F1.4171.00
55_R97_N1.4131.00
36_L88_S1.4101.00
96_I100_T1.4091.00
7_K12_V1.3911.00
7_K186_N1.3841.00
97_N117_K1.3821.00
158_G164_D1.3691.00
105_I124_T1.3611.00
26_L65_E1.3451.00
17_R20_K1.3431.00
33_I37_K1.3421.00
25_N28_M1.3421.00
149_R152_E1.3341.00
153_I160_F1.3331.00
198_A224_Y1.3221.00
123_V159_E1.3111.00
127_Q157_G1.3061.00
201_R205_L1.2991.00
40_N88_S1.2611.00
15_I28_M1.2471.00
191_G196_Y1.2461.00
148_Q172_K1.2421.00
231_F235_I1.2391.00
33_I80_P1.2381.00
99_V121_K1.2361.00
31_E35_K1.2361.00
149_R164_D1.2341.00
174_S177_P1.2301.00
56_A99_V1.2041.00
209_N213_R1.1881.00
15_I58_C1.1731.00
177_P180_D1.1691.00
160_F168_W1.1621.00
146_R149_R1.1581.00
58_C104_C1.1241.00
20_K64_N1.1201.00
205_L217_Y1.0981.00
87_F212_E1.0981.00
78_F135_T1.0881.00
31_E34_S1.0801.00
48_V90_K1.0761.00
17_R62_D1.0761.00
26_L30_N1.0741.00
34_S38_E1.0711.00
194_Q230_D1.0611.00
6_N38_E1.0531.00
166_E171_L1.0501.00
113_F184_M1.0451.00
209_N217_Y1.0301.00
92_Y111_T1.0121.00
54_G97_N1.0051.00
106_G137_V1.0011.00
145_T149_R0.9961.00
51_T95_A0.9761.00
48_V92_Y0.9761.00
185_A189_L0.9751.00
5_D14_T0.9751.00
138_A218_E0.9711.00
45_I90_K0.9591.00
43_P90_K0.9571.00
35_K38_E0.9561.00
179_Y182_E0.9561.00
139_Y214_F0.9551.00
163_E166_E0.9491.00
6_N44_K0.9461.00
121_K161_T0.9451.00
117_K176_N0.9431.00
12_V49_I0.9431.00
49_I181_A0.9421.00
5_D12_V0.9411.00
105_I122_F0.9361.00
96_I122_F0.9321.00
144_L148_Q0.9241.00
193_F197_I0.9231.00
89_D197_I0.9161.00
201_R221_I0.9141.00
113_F172_K0.9101.00
188_I196_Y0.9101.00
29_R81_I0.9071.00
21_L59_V0.9071.00
213_R216_E0.9051.00
127_Q199_G0.9031.00
181_A185_A0.8981.00
10_Y47_T0.8981.00
96_I114_K0.8961.00
232_K236_S0.8901.00
132_A225_L0.8761.00
141_L145_T0.8661.00
217_Y220_A0.8581.00
202_M221_I0.8481.00
147_D207_L0.8371.00
106_G126_F0.8361.00
37_K80_P0.8351.00
39_I45_I0.8331.00
178_L181_A0.8321.00
33_I77_T0.8321.00
198_A221_I0.8301.00
36_L85_I0.8261.00
64_N239_K0.8231.00
102_G125_A0.8211.00
6_N45_I0.8171.00
115_F173_I0.8161.00
154_A203_A0.8151.00
13_V48_V0.8151.00
153_I168_W0.8121.00
182_E185_A0.8091.00
145_T153_I0.8071.00
37_K41_A0.8021.00
146_R150_A0.8001.00
101_A159_E0.7961.00
192_P230_D0.7921.00
40_N90_K0.7901.00
30_N34_S0.7811.00
56_A97_N0.7781.00
50_L111_T0.7751.00
33_I81_I0.7721.00
128_R159_E0.7701.00
25_N65_E0.7641.00
17_R25_N0.7631.00
49_I182_E0.7631.00
26_L77_T0.7621.00
187_K191_G0.7601.00
183_E186_N0.7511.00
198_A225_L0.7491.00
24_L28_M0.7431.00
198_A201_R0.7401.00
156_L184_M0.7401.00
235_I239_K0.7401.00
82_I110_S0.7391.00
89_D201_R0.7381.00
229_E232_K0.7371.00
152_E156_L0.7351.00
46_R193_F0.7341.00
139_Y142_L0.7331.00
162_A171_L0.7331.00
39_I90_K0.7311.00
96_I120_V0.7301.00
109_L170_L0.7281.00
162_A166_E0.7221.00
126_F134_D0.7211.00
21_L99_V0.7141.00
115_F181_A0.7141.00
165_A170_L0.7141.00
219_S223_G0.7121.00
221_I224_Y0.7121.00
217_Y221_I0.7091.00
88_S92_Y0.7091.00
183_E187_K0.7051.00
10_Y49_I0.7001.00
17_R23_A0.6941.00
211_L215_L0.6931.00
93_I185_A0.6921.00
76_E80_P0.6921.00
50_L92_Y0.6911.00
42_N45_I0.6901.00
76_E219_S0.6871.00
49_I95_A0.6861.00
193_F196_Y0.6821.00
106_G134_D0.6791.00
28_M31_E0.6791.00
186_N190_N0.6771.00
6_N9_G0.6771.00
194_Q228_T0.6761.00
216_E220_A0.6741.00
122_F171_L0.6731.00
9_G44_K0.6671.00
220_A224_Y0.6661.00
101_A125_A0.6651.00
126_F133_S0.6651.00
149_R166_E0.6651.00
88_S91_I0.6621.00
27_E30_N0.6571.00
123_V157_G0.6571.00
233_E240_E0.6541.00
132_A202_M0.6541.00
35_K39_I0.6531.00
202_M217_Y0.6531.00
61_A66_F0.6501.00
116_A120_V0.6461.00
133_S199_G0.6461.00
42_N90_K0.6451.00
126_F222_Q0.6441.00
47_T93_I0.6401.00
95_A178_L0.6401.00
67_A236_S0.6371.00
230_D234_G0.6351.00
32_L81_I0.6281.00
212_E216_E0.6161.00
10_Y185_A0.6141.00
147_D204_N0.6141.00
147_D203_A0.6141.00
34_S37_K0.6101.00
233_E237_S0.6101.00
234_G237_S0.6031.00
229_E233_E0.6011.00
94_A114_K0.5991.00
13_V50_L0.5981.00
97_N120_V0.5981.00
37_K40_N0.5971.00
13_V36_L0.5931.00
51_T179_Y0.5931.00
161_T167_R0.5911.00
236_S239_K0.5881.00
138_A214_F0.5871.00
155_V196_Y0.5861.00
205_L209_N0.5861.00
36_L84_E0.5831.00
156_L188_I0.5811.00
145_T150_A0.5801.00
113_F188_I0.5781.00
233_E236_S0.5781.00
69_D73_D0.5781.00
144_L172_K0.5771.00
95_A185_A0.5761.00
106_G136_G0.5761.00
131_L231_F0.5701.00
160_F165_A0.5681.00
45_I48_V0.5681.00
99_V159_E0.5661.00
10_Y182_E0.5661.00
187_K190_N0.5641.00
124_T137_V0.5641.00
97_N175_E0.5631.00
199_G202_M0.5601.00
145_T168_W0.5581.00
139_Y143_K0.5561.00
108_S111_T0.5561.00
117_K120_V0.5551.00
119_E162_A0.5541.00
209_N214_F0.5531.00
46_R189_L0.5531.00
127_Q191_G0.5521.00
142_L145_T0.5521.00
110_S140_F0.5481.00
142_L206_V0.5471.00
103_A135_T0.5471.00
20_K62_D0.5461.00
36_L92_Y0.5461.00
102_G124_T0.5451.00
105_I170_L0.5441.00
63_V66_F0.5431.00
124_T154_A0.5431.00
13_V39_I0.5421.00
27_E65_E0.5401.00
130_G192_P0.5381.00
231_F234_G0.5381.00
80_P83_R0.5361.00
20_K23_A0.5361.00
47_T189_L0.5361.00
165_A171_L0.5331.00
106_G124_T0.5331.00
23_A59_V0.5321.00
149_R167_R0.5321.00
38_E41_A0.5311.00
29_R33_I0.5311.00
105_I109_L0.5301.00
106_G140_F0.5301.00
25_N62_D0.5281.00
216_E219_S0.5271.00
176_N179_Y0.5261.00
117_K178_L0.5251.00
184_M187_K0.5231.00
225_L228_T0.5231.00
67_A239_K0.5201.00
36_L48_V0.5161.00
24_L103_A0.5161.00
47_T181_A0.5141.00
81_I84_E0.5141.00
124_T141_L0.5141.00
156_L187_K0.5131.00
143_K210_D0.5131.00
94_A108_S0.5121.00
152_E164_D0.5111.00
194_Q225_L0.5111.00
63_V129_L0.5081.00
24_L29_R0.5081.00
86_R211_L0.5051.00
114_K171_L0.5051.00
133_S154_A0.5041.00
126_F136_G0.5031.00
151_Y200_K0.5031.00
67_A235_I0.5021.00
103_A106_G0.5011.00
113_F156_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jfcA 3 0.992 100 0.097 Contact Map
4lk5A 3 0.9759 100 0.099 Contact Map
1nzyA 4 1 100 0.103 Contact Map
4og1A 3 0.9679 100 0.104 Contact Map
2fbmA 3 0.9518 100 0.104 Contact Map
3sllA 6 0.988 100 0.106 Contact Map
3g64A 6 1 100 0.106 Contact Map
3bptA 1 0.996 100 0.107 Contact Map
1uiyA 6 0.9799 100 0.108 Contact Map
3qxzA 3 0.996 100 0.108 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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