GREMLIN Database
Q97VK0 - Enoyl CoA hydratase (PaaF-7)
UniProt: Q97VK0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (247)
Sequences: 30114 (19710)
Seq/√Len: 1254.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_K170_L3.0971.00
129_E187_P2.9921.00
184_K194_E2.9051.00
127_A182_V2.8711.00
105_A122_C2.7581.00
194_E197_R2.6091.00
22_I196_I2.5711.00
47_N95_K2.4291.00
50_D100_K2.4011.00
169_K201_E2.2291.00
16_V21_G2.2191.00
175_E178_R2.1411.00
31_L65_K2.1021.00
13_Q26_N2.0941.00
130_S188_D2.0741.00
22_I61_T2.0501.00
224_L227_Q2.0251.00
172_D175_E2.0211.00
129_E174_K1.9661.00
163_E169_K1.9601.00
31_L66_A1.9381.00
19_N56_K1.9381.00
160_K179_Y1.9371.00
43_V95_K1.9291.00
139_N205_K1.9111.00
106_A195_A1.9061.00
24_K63_N1.9051.00
165_V213_A1.8981.00
16_V52_D1.8911.00
14_I21_G1.8571.00
106_A192_I1.8431.00
250_R254_E1.8411.00
24_K61_T1.8241.00
26_N63_N1.8241.00
196_I200_R1.7651.00
112_A134_G1.7391.00
126_I186_V1.7221.00
48_K52_D1.7151.00
37_Q41_E1.7061.00
162_M218_A1.7021.00
21_G49_L1.6831.00
190_S193_D1.6451.00
158_K162_M1.6351.00
247_E256_R1.6231.00
21_G55_I1.6161.00
163_E183_N1.6001.00
175_E179_Y1.5881.00
11_T41_E1.5851.00
190_S194_E1.5731.00
58_V99_F1.5651.00
11_T35_N1.5321.00
126_I198_L1.5251.00
127_A133_L1.5221.00
163_E184_K1.5141.00
129_E188_D1.5031.00
40_D88_G1.5021.00
174_K178_R1.5011.00
50_D95_K1.4941.00
186_V194_E1.4881.00
49_L58_V1.4791.00
94_E98_T1.4701.00
123_D214_K1.4661.00
17_I196_I1.4551.00
23_I45_V1.4411.00
125_I159_Y1.4311.00
107_L119_A1.4291.00
13_Q63_N1.4071.00
162_M166_L1.3981.00
43_V47_N1.3851.00
94_E226_Q1.3771.00
119_A125_I1.3711.00
212_L238_L1.3691.00
18_D200_R1.3651.00
128_S188_D1.3651.00
125_I155_V1.3501.00
108_N128_S1.3391.00
177_E185_V1.3361.00
14_I49_L1.3341.00
108_N130_S1.3241.00
46_L99_F1.3191.00
160_K163_E1.3061.00
162_M217_V1.3001.00
164_L171_I1.2851.00
116_L135_Q1.2781.00
169_K175_E1.2771.00
96_L103_V1.2741.00
107_L111_T1.2731.00
22_I192_I1.2721.00
57_V199_A1.2671.00
17_I22_I1.2641.00
97_R151_R1.2481.00
66_A110_I1.2481.00
17_I200_R1.2421.00
61_T192_I1.2401.00
110_I132_K1.2331.00
61_T108_N1.2331.00
43_V91_P1.2261.00
27_R30_K1.2231.00
36_F75_E1.2201.00
50_D99_F1.2121.00
192_I196_I1.1991.00
223_T227_Q1.1961.00
15_E24_K1.1931.00
134_G170_L1.1931.00
159_Y183_N1.1871.00
215_E219_R1.1741.00
160_K175_E1.1691.00
16_V54_K1.1691.00
65_K108_N1.1571.00
35_N38_M1.1521.00
41_E45_V1.1441.00
25_L38_M1.1431.00
30_K74_K1.1321.00
223_T231_F1.1301.00
192_I195_A1.1221.00
219_R231_F1.1201.00
13_Q24_K1.1071.00
205_K210_I1.1051.00
15_E22_I1.1031.00
245_A249_M1.0971.00
171_I179_Y1.0961.00
98_T226_Q1.0881.00
36_F40_D1.0881.00
191_L195_A1.0821.00
128_S191_L1.0811.00
173_S185_V1.0771.00
11_T37_Q1.0751.00
16_V48_K1.0701.00
157_G160_K1.0661.00
138_I168_G1.0531.00
41_E44_D1.0421.00
58_V101_K1.0201.00
25_L68_S1.0191.00
45_V48_K1.0181.00
199_A203_A1.0151.00
61_T106_A1.0141.00
117_E148_G1.0121.00
156_L160_K1.0091.00
103_V122_C0.9971.00
58_V103_V0.9921.00
155_V159_Y0.9911.00
124_I198_L0.9831.00
89_H146_A0.9821.00
100_K211_I0.9771.00
174_K177_E0.9751.00
193_D197_R0.9721.00
44_D48_K0.9711.00
129_E185_V0.9701.00
187_P190_S0.9691.00
208_I244_E0.9691.00
246_K250_R0.9561.00
68_S115_G0.9551.00
106_A191_L0.9361.00
20_I57_V0.9311.00
116_L133_L0.9311.00
212_L215_E0.9291.00
215_E235_N0.9271.00
59_I195_A0.9261.00
158_K221_W0.9211.00
55_I101_K0.9071.00
177_E182_V0.9051.00
27_R72_D0.9041.00
227_Q230_D0.8961.00
132_K172_D0.8901.00
212_L235_N0.8861.00
207_I211_I0.8761.00
138_I213_A0.8721.00
196_I199_A0.8701.00
231_F234_R0.8671.00
39_V92_L0.8661.00
64_G108_N0.8581.00
107_L133_L0.8531.00
22_I59_I0.8451.00
143_M239_A0.8431.00
197_R201_E0.8421.00
31_L69_A0.8401.00
43_V88_G0.8381.00
195_A199_A0.8371.00
47_N51_N0.8301.00
112_A170_L0.8291.00
80_P83_E0.8261.00
150_Q228_G0.8261.00
23_I58_V0.8251.00
177_E184_K0.8231.00
164_L179_Y0.8211.00
108_N191_L0.8161.00
165_V217_V0.8131.00
128_S189_N0.8111.00
163_E167_T0.8111.00
74_K253_L0.8051.00
16_V55_I0.8021.00
46_L96_L0.8001.00
212_L239_A0.7901.00
152_L156_L0.7881.00
124_I183_N0.7851.00
36_F88_G0.7831.00
219_R223_T0.7791.00
107_L125_I0.7791.00
231_F235_N0.7781.00
149_T232_E0.7771.00
193_D196_I0.7761.00
204_E257_K0.7741.00
184_K198_L0.7711.00
40_D44_D0.7661.00
12_I45_V0.7661.00
53_D101_K0.7641.00
225_L229_L0.7631.00
50_D101_K0.7621.00
173_S182_V0.7611.00
156_L164_L0.7601.00
139_N170_L0.7591.00
11_T38_M0.7581.00
235_N238_L0.7571.00
202_I210_I0.7491.00
243_K246_K0.7471.00
14_I45_V0.7421.00
150_Q153_T0.7401.00
47_N91_P0.7391.00
201_E205_K0.7381.00
60_I122_C0.7371.00
93_W121_A0.7371.00
194_E198_L0.7351.00
49_L55_I0.7321.00
216_A235_N0.7271.00
120_M181_L0.7221.00
126_I184_K0.7211.00
176_A181_L0.7201.00
100_K215_E0.7201.00
66_A108_N0.7191.00
27_R35_N0.7171.00
197_R200_R0.7161.00
43_V92_L0.7161.00
158_K218_A0.7111.00
52_D55_I0.7101.00
56_K207_I0.7101.00
233_R237_Y0.7081.00
200_R204_E0.7061.00
34_I38_M0.7061.00
87_K233_R0.7021.00
157_G161_A0.7011.00
31_L110_I0.7001.00
99_F103_V0.6861.00
84_I88_G0.6851.00
206_P244_E0.6831.00
87_K91_P0.6771.00
198_L201_E0.6771.00
249_M253_L0.6761.00
107_L131_A0.6741.00
59_I106_A0.6741.00
35_N75_E0.6691.00
167_T198_L0.6661.00
133_L182_V0.6651.00
117_E137_E0.6631.00
104_I199_A0.6621.00
77_L250_R0.6611.00
27_R33_A0.6571.00
19_N54_K0.6551.00
37_Q40_D0.6511.00
160_K177_E0.6481.00
182_V185_V0.6481.00
59_I196_I0.6471.00
230_D234_R0.6471.00
16_V19_N0.6471.00
45_V49_L0.6441.00
112_A136_P0.6431.00
47_N50_D0.6431.00
143_M216_A0.6421.00
186_V191_L0.6401.00
20_I59_I0.6381.00
60_I103_V0.6341.00
14_I48_K0.6331.00
57_V203_A0.6241.00
38_M41_E0.6241.00
127_A131_A0.6231.00
52_D101_K0.6221.00
57_V104_I0.6221.00
174_K185_V0.6181.00
110_I170_L0.6161.00
150_Q154_R0.6081.00
91_P95_K0.6071.00
108_N188_D0.6071.00
226_Q230_D0.6061.00
216_A231_F0.6051.00
243_K247_E0.6051.00
166_L210_I0.6041.00
250_R253_L0.6031.00
14_I23_I0.6021.00
134_G168_G0.6001.00
20_I196_I0.6001.00
247_E251_A0.5991.00
149_T228_G0.5971.00
158_K217_V0.5961.00
56_K203_A0.5931.00
91_P94_E0.5931.00
234_R238_L0.5931.00
208_I242_T0.5921.00
44_D47_N0.5911.00
126_I195_A0.5911.00
191_L194_E0.5901.00
113_G136_P0.5871.00
171_I176_A0.5861.00
105_A125_I0.5861.00
126_I191_L0.5841.00
156_L161_A0.5831.00
30_K72_D0.5821.00
144_P213_A0.5811.00
42_L92_L0.5791.00
130_S173_S0.5791.00
116_L181_L0.5781.00
126_I194_E0.5781.00
247_E250_R0.5761.00
167_T201_E0.5751.00
137_E145_G0.5751.00
49_L101_K0.5741.00
20_I199_A0.5741.00
99_F102_P0.5711.00
119_A122_C0.5701.00
213_A216_A0.5701.00
135_Q148_G0.5691.00
71_A76_M0.5661.00
11_T27_R0.5651.00
23_I60_I0.5641.00
142_I245_A0.5601.00
155_V183_N0.5591.00
46_L103_V0.5581.00
156_L179_Y0.5551.00
163_E198_L0.5541.00
167_T202_I0.5481.00
163_E175_E0.5481.00
39_V43_V0.5471.00
125_I182_V0.5451.00
77_L253_L0.5441.00
135_Q165_V0.5431.00
23_I49_L0.5421.00
46_L95_K0.5421.00
124_I202_I0.5401.00
208_I239_A0.5401.00
73_V140_L0.5361.00
248_G251_A0.5341.00
105_A119_A0.5341.00
34_I114_G0.5341.00
138_I210_I0.5331.00
160_K178_R0.5331.00
230_D233_R0.5301.00
201_E204_E0.5301.00
37_Q75_E0.5281.00
172_D178_R0.5241.00
90_M94_E0.5241.00
121_A151_R0.5231.00
138_I205_K0.5231.00
173_S177_E0.5221.00
23_I46_L0.5201.00
128_S131_A0.5191.00
137_E144_P0.5181.00
223_T228_G0.5181.00
117_E135_Q0.5181.00
135_Q152_L0.5151.00
247_E254_E0.5151.00
55_I58_V0.5101.00
97_R218_A0.5081.00
24_K192_I0.5081.00
244_E248_G0.5081.00
153_T156_L0.5061.00
162_M214_K0.5051.00
154_R224_L0.5041.00
153_T161_A0.5031.00
214_K218_A0.5021.00
106_A199_A0.5011.00
117_E145_G0.5011.00
88_G91_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lk5A 3 0.9436 100 0.097 Contact Map
1nzyA 4 0.9737 100 0.097 Contact Map
4jfcA 3 0.9474 100 0.101 Contact Map
2fbmA 3 0.9173 100 0.103 Contact Map
4mi2A 3 0.9549 100 0.104 Contact Map
1mj3A 5 0.9586 100 0.106 Contact Map
3g64A 6 0.9887 100 0.106 Contact Map
3qreA 3 0.7368 100 0.108 Contact Map
3bptA 1 0.9774 100 0.108 Contact Map
3peaA 3 0.9586 100 0.108 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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